Digital Commons Network^™

Proof And Supporting Sites For Integrating R, D&E In Grazing Systems Research, Ian Simpson, Warren Mason

IGC Proceedings (1977-2023)

No abstract provided.

The Adoption Of Sustainable Grazing Land Management Practices In The Burdekin Rangelands Of Northern Australia, Robert N. Shepherd

IGC Proceedings (1977-2023)

No abstract provided.

Smallholder Innovation And Adoption Of Hay And Silage Technologies In Honduras, Christoph Reiber, R. Schultze‐Kraft, M. Peters, H. Cruz

IGC Proceedings (1977-2023)

No abstract provided.

Neutrophil Myeloperoxidase Derived Chlorolipid Production During Bacteria Exposure, Kaushalya Amunugama, Grant R. Kolar, David A. Ford

Biological Sciences Faculty Research & Creative Works

Neutrophils are the most abundant white blood cells recruited to the sites of infection and inflammation. During neutrophil activation, myeloperoxidase (MPO) is released and converts hydrogen peroxide to hypochlorous acid (HOCl). HOCl reacts with plasmalogen phospholipids to liberate 2-chlorofatty aldehyde (2-ClFALD), which is metabolized to 2-chlorofatty acid (2-ClFA). 2-ClFA and 2-ClFALD are linked with inflammatory diseases and induce endothelial dysfunction, neutrophil extracellular trap formation (NETosis) and neutrophil chemotaxis. Here we examine the neutrophil-derived chlorolipid production in the presence of pathogenic E. coli strain CFT073 and non-pathogenic E. coli strain JM109. Neutrophils cocultured with CFT073 E. coli strain and JM109 E. …

Neutrophil Myeloperoxidase Derived Chlorolipid Production During Bacteria Exposure, Kaushalya Amunugama, Grant R. Kolar, David A. Ford

Biological Sciences Faculty Research & Creative Works

Neutrophils are the most abundant white blood cells recruited to the sites of infection and inflammation. During neutrophil activation, myeloperoxidase (MPO) is released and converts hydrogen peroxide to hypochlorous acid (HOCl). HOCl reacts with plasmalogen phospholipids to liberate 2-chlorofatty aldehyde (2-ClFALD), which is metabolized to 2-chlorofatty acid (2-ClFA). 2-ClFA and 2-ClFALD are linked with inflammatory diseases and induce endothelial dysfunction, neutrophil extracellular trap formation (NETosis) and neutrophil chemotaxis. Here we examine the neutrophil-derived chlorolipid production in the presence of pathogenic E. coli strain CFT073 and non-pathogenic E. coli strain JM109. Neutrophils cocultured with CFT073 E. coli strain and JM109 E. …

Status Of Vitamin D In Children With Pediatric Acute-Onset Neuropsychiatric Syndrome (Pans), Gabriel Delgado '22

2021 Intern Reports

Numerous studies from the National Center for Biotechnology Information (NCBI) have proven that there is an association between autoimmunity regulation and Vitamin D deficiency. Consequently, it has been theorized that improvement of Vitamin D levels will also help moderate autoimmunity levels. However, there are not many studies, if any, on the regulation of the PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections) autoimmune disease by Vitamin D in child patients. Over a 7 month period, measurement data of 122 total patients with PANDAS, including vitamin D 25-hydroxy level, gender, and age of diagnosis, were collected from the MASA (Midwest …

What Are The Most Effective Risk Factor Management Strategies For The Prevention And Control Of Hypertension?, Sherlyne Barasa

Theses and Graduate Projects

Hypertension (HTN) affects millions of people globally. With the rising burden of HTN in primary care and its associated morbidity and mortality, it is necessary to explore effective risk factor management to control and prevent it in people most at risk. This research addressed both modifiable risk factors such as obesity, smoking, alcohol, and diet as well as non- modifiable risk factors such as age, race/ethnicity, and family history. The aim of this paper was to examine the most effective risk factor management strategies to control and prevent hypertension. The studies reviewed indicate that there are various risk factor management …

Occupational Factors And Risk For Preterm Birth, Kelsey Forbes

Theses and Graduate Projects

Introduction: Preterm birth (PTB) is a leading contributor to infant death globally and in the United States. The biological mechanisms and etiologies for PTB are not well understood making prevention challenging. The correlation between increased number of women in the workforce and increased incidence of PTB in the U.S. inspired a thorough review of occupational risk factors that may contribute to shortened gestational length.

Background: The studies reviewed assessed the following occupational factors and their association with PTB: physical job demands, exposure to whole-body vibration and noise, shift work, long working hours, and psychosocial job strain.

Methods: A systematic search …

Guiding Change: A Multidisciplinary Framework For Interventions Addressing Systemic Racism In Healthcare, Lavette D. King

Master's Projects and Capstones

The relationship between systemic and institutional racism in the U.S., and health outcomes in people of the African Diaspora have been well documented (Bailey et al., 2017). Distrust in the healthcare system is the result of generational trauma compounded by an ongoing issue that has yet to be fully addressed (Scharff et al., 2015). For decades people of African descent have expressed concern about negative experiences with the U.S. healthcare system. Often the encounters leave them feeling, mistreated, unheard and or criminalized. These feelings result in trepidation over using the healthcare system which often further compounds health issues (Washington, 2008). …

Trauma Characteristics Moderate The Relation Between Estradiol And Trauma-Related Symptoms, Jenna K Rieder, Olena Kleshchova, Mariann R Weierich

College of Humanities and Sciences Faculty Papers

Women are more likely to develop posttraumatic stress disorder (PTSD) than men, and fluctuations in gonadal hormones might contribute to this vulnerability. Low-estradiol states are associated with aversive affective experiences, including trauma-related symptoms. However, the impact of trauma characteristics on the relation between estradiol and trauma-related symptoms is unknown. We used a clinical interview and 10-day ecological momentary assessment (EMA) that spanned low- and high-estradiol menstrual cycle phases to test trauma type, chronicity, and timing as moderators of the association between estradiol and trauma-related symptoms in 40 naturally cycling young women. We tested interactions between trauma characteristics and (a) estradiol …

Neuronal Nsun2 Deficiency Produces Trna Epitranscriptomic Alterations And Proteomic Shifts Impacting Synaptic Signaling And Behavior., J Blaze, A Navickas, H L Phillips, S Heissel, A Plaza-Jennings, S Miglani, H Asgharian, M Foo, C D Katanski, C P Watkins, Z T Pennington, B Javidfar, S Espeso-Gil, B Rostandy, H Alwaseem, C G Hahn, H Molina, D J Cai, T Pan, W D Yao, H Goodarzi, F Haghighi, S Akbarian

Department of Neuroscience Faculty Papers

Epitranscriptomic mechanisms linking tRNA function and the brain proteome to cognition and complex behaviors are not well described. Here, we report bi-directional changes in depression-related behaviors after genetic disruption of neuronal tRNA cytosine methylation, including conditional ablation and transgene-derived overexpression of Nsun2 in the mouse prefrontal cortex (PFC). Neuronal Nsun2-deficiency was associated with a decrease in tRNA m⁵C levels, resulting in deficits in expression of 70% of tRNA^Gly isodecoders. Altogether, 1488/5820 proteins changed upon neuronal Nsun2-deficiency, in conjunction with glycine codon-specific defects in translational efficiencies. Loss of Gly-rich proteins critical for glutamatergic neurotransmission was associated with impaired …

Procedural Rhetoric And Language: How The Orwell Videogames Series Emphasizes The Importance Of Context In Content, Jessica Kimber

English Theses

Procedural Rhetoric and Language: How the Orwell Videogames Series Emphasizes the Importance of Context in Content

Protective Factors That Foster Resilience To Hiv/Aids: Insights And Lived Experiences Of Older Gay, Bisexual, And Other Men Who Have Sex With Men, Renato M. Liboro, Tammy C. Yates, Sherry Bell, Brandon Ranuschio, George Da Silva, Charles Fehr, Francisco Ibañez-Carrasco, Paul A. Shuper

Psychology Faculty Research

Since the beginning of the HIV/AIDS epidemic, gay, bisexual, and other men who have sex with men (gbMSM) have been disproportionately impacted by HIV/AIDS health disparities. Research showed that resilience to HIV/AIDS is associated with increased use of relevant health services, lower sexual health risks, and improved mental health outcomes among racially and ethnically diverse gbMSM. As the subpopulation that has historically been impacted by HIV/AIDS the longest, older gbMSM living with HIV/AIDS have inarguably exhibited resilience to HIV/AIDS the most. The qualitative study described in this paper sought to identify and examine protective factors that fostered resilience to HIV/AIDS …

Daily Energy Expenditure Through The Human Life Course, Herman Pontzer, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Lene F. Andersen, Liam J. Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-Addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V.C. Bouten, Pascal Bovet, Maciej S. Buchowski, Nancy F. Butte, Stefan G. Camps, Graeme L. Close, Jamie A. Cooper, Richard Cooper, Sai Krupa Das, Lara R. Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Annelies H. Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marjije B. Hoos, Sumei Hu, Noorjehan Joonas

Faculty Publications

Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to …

Another Time, Another Place: The Truth Of Silence In J.M. Coetzee's Disgrace, Sara T. Murphy

Theses and Dissertations

Through Lucy’s rejection of the criminal justice system, Coetzee's Disgrace operates as an allegory for the failure of the Truth and Reconciliation Commission to provide individual justice and reparations to victims of Apartheid.

Structural And Inhibitory Studies Of Enzymes Essential For Cell Wall And Ergothioniene Biosynthesis In Mycobacterium Tuberculosis, Thanuja D. Sudasinghe

Theses & Dissertations

Tuberculosis (TB) is one of the world’s oldest contagious diseases caused by Mycobacterium tuberculosis (M. tb). With the emergence and spread of drug-resistant M. tb strains, there is an urgent need to discover novel drugs and drug targets specifically against drug-resistant strains and dormant bacteria. This dissertation focuses on M. tbenzymes essential for the M. tb cell wall and ergothioneine biosynthesis. The M. tb cell wall acts as a protective barrier due to the presence of unique lipids and mycolic acids. Among these lipids, trehalose-dimycolate and mycolylarabinogalactan play a major role in constructing and maintaining the outer …

College Of Liberal Arts Faculty Bylaws - Amended 8/13/21, College Of Liberal Arts Faculty, Rollins College

College of Liberal Arts Bylaws

No abstract provided.

Health Service Utilization And Expenditure In Cardio-Metabolic Conditions In The United States Adults, Kavita Mosalpuria

Theses & Dissertations

Metabolic syndrome is multicomponent risk factor for cardiovascular diseases (CVD) and type 2 diabetes that reflects the clustering of at least 3 cardiometabolic risk factors, among hypertension, impaired glucose regulations, hypercholesterolemia, and obesity. CVD are the leading cause of death in the U.S. CVD occur at earlier age and is a major cause of death and disability among people with diabetes. As compared to Japan, 13.3% to 44% of the excess CVD mortality in the U.S. can be explained by the metabolic syndrome. The prevalence of metabolic syndrome was 34.3% in 2007 to 2014 and it increases with age. Metabolic …

Respons Fisiologi Dan Hasil Lateks Tanaman Karet Klon Gt 1 Di Kebun Karet Rakyat Terhadap Sistem Eksploitasi Dan Curah Hujan, Yayuk Purwaningrum, Yenni Asbur, Dedi Kusbiantoro, Khairunnisyah

Jurnal Kultivasi

Klon GT 1 adalah klon Slow Starter (SS) dimana perubahan sukrosa menjadi partikel karet di dalam pembuluh lateks berlangsung lambat dan pada saat gugur daun hasil lateks lebih stabil. Penelitian ini bertujuan untuk mengetahui hubungan curah hujan dan sistem eksploitasi terhadap fisiologi dan hasil lateks klon GT1. Penelitian dilaksanakan di Kabupaten Langkat Kecamatan Besitang Sumatera Utara, ketinggian tempat 500 – 700 m di atas permukaan laut. Analisa fisiologi lateks di PT. Sucofindo Indonesia. Tanaman yang digunakan adalah klon GT 1 umur 25 tahun dengan besar lilit batang antara 60 – 75 cm, diukur dengan ketinggian 130 cm dari permukaan tanah. …

How To Avoid The Use Of Chemicals To Control Parasites In Salmon Farming?, Cintya Gajardo Vejar

International Programs

The development of salmon farming in the world has been accompanied by a number of conditions like parasitism by Sea Lice (Caligus rogercresseyi), this problem occurs in the fattening stage of Atlantic Salmon (Salmo salar) in the sea, increasing mortality and generating economic losses. The salmon industry efforts have focused on resolving the Sea Lice parasitism (C. rogercresseyi) through the use of antibiotics to control the infestation and the use of vaccines to prevent it, but it presents biological implications for salmon, the marine environment and human health.

Why Wetlands Conservation In The Paraguayan Humid Chaco Is Crucial, Laura Rossana Macedo Amarilla

International Programs

This poster discusses the importance of wetland conservation and the impact of ecosystem services on human well-being in the Paraguayan Humid Chaco, a vulnerable zone with high biological diversity.

Synthesis Of Nanofibers For The Development Of Artificial Tactile Sensor, Pertab Rai

International Programs

Tactile sensation in human skin is performed by specialized cells called mechanoreceptors. Factors such as surgical procedures, skin burns, injury, and nerve damage may lead to impaired sensation. For these reasons, various methods and approaches are developed to revive tactile sensation. In this poster, a step-by-step procedure to synthesize nanofibers for the development of artificial tactile sensor is presented.

Patient Experience As A Metric For Performance In Outpatient Bone Marrow Transplant Patient Populations, Olivia S. Marlinski

Master's Projects and Capstones

Problem: Patient satisfaction and perception of care provided have been linked to the overall quality of healthcare delivery. The Acute Infection Management clinical support department lacks a standardized method to collect information from patients regarding their satisfaction with care provided therefore impeding the units’ ability to capture performance results related to satisfaction, and improve care delivery processes accordingly.

Context: The Acute Infection Management unit is an outpatient clinical support department located within a large university-affiliated hospital that has been recently designated as the unit to operate the facility’s new outpatient bone marrow transplant program.

Intervention: The proposed project seeks to …

Assessment Of The Effects Of Airflow Conditions Related To Hop Drying, David Mabie

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Hops have been utilized by brewers for centuries to contribute bitterness, antimicrobial preservation and desirable aromatic profiles to beer. The hop cone is a small, lightweight, high moisture content flower which produces lupulin glands containing resins and essential oils that contribute desirable characteristics to beer. Due to the high harvest moisture content (75% wet basis), hops must be rapidly dried to properly preserve them for future processing and brewing. While hops have been dried for centuries, most literature from the past century has focused on drying to minimizing loss to the resin or physical cone structure. The objectives of this …

Strainiq: An N-Gram-Based Method To Identify And Quantify Microbial Communities In Metagenomic Samples, Sanjit Pandey

Theses & Dissertations

Microbes are ubiquitous in nature, and they play vital roles in various processes associated with metabolism in the human body, photosynthesis in plants, or decomposition of waste in the environment. Hence, it is essential to understand how the composition of microbial communities affects the ecosystem of different environments ranging from ocean floors to hot springs to the human body. Microbial communities present in different human body sites are of particular importance due to their implications in the cause and prevention of human diseases. The traditional approaches limit microbial research to exclusively studying species that can be successfully cultured in the …

Proof Of Concept: The Use Of Renal Biomarkers In Critically Ill Pediatric Patients For Therapeutic Drug Monitoring, Christopher Lee Shaffer

Theses & Dissertations

Acute kidney injury (AKI) is a serious and common complication in critically ill pediatric patients. The incidence of pediatric AKI continues to increase, especially in patients who undergo surgical correction of congenital heart defects. Serum creatinine and urine output are the most commonly used tools to assess renal function, with international guidelines standardizing AKI-definitions based upon these parameters. However, changes in serum creatinine can occur 24 hours or later after a renal insult event, delaying the diagnosis and potential interventions to reverse injury. It is critical to identify endogenous renal biomarkers within the pediatric population that are both timely and …

The Effect Of Simvastatin On Periodontonal Inflammation In Periodontal Maintenance Patients, Devin L. Christiansen

Theses & Dissertations

The purpose of this analysis of inflammation markers from a double blinded, randomized, controlled clinical trial was to determine if local application of simvastatin, combined with minimally invasive papilla reflection/root preparation (PR/RP) is effective in reducing markers of inflammation: 1) bleeding upon probing (BOP), 2) tissue inflammatory / anti-inflammatory gene activation (rt-PCR) and 3) corresponding gingival crevicular fluid (GCF) protein production in non-resolving 6-9 mm periodontal pockets in patients on periodontal maintenance therapy (PMT). Fifty periodontal maintenance patients diagnosed with advanced chronic adult periodontitis presenting with a 6-9 mm interproximal PD were included in study. Experimental (PR/RP+SIM; n=27) and control …

Urinary Bile Acid Indices As Prognostic Biomarkers For The Complications Of Liver Diseases, Wenkuan Li

Theses & Dissertations

Hepatobilary diseases cause the accumulation of toxic bile acids (BA) in the liver, blood, and other tissues, which may lead to an unfavorable prognosis. In this study, we compared the urinary BA profile in 257 patients with hepatobilary diseases during a 7-year follow-up period. We investigated the use of the urinary BA profile to develop logistic regression models to predict the prognosis of hepatobiliary diseases in terms of developing disease-related complications, especially for ascites. The urinary BA profile was characterized by calculating BA indices, which quantify the composition, metabolism, hydrophilicity, and toxicity of the BA profile. All patients had high …

Perinatal Periods Of Risk: Examination Of Data Quality & Inclusion Criteria, New Unbiased Reference Groups, And A Nationwide County-Level Analysis, Carol S. Gilbert

Theses & Dissertations

Records of births, infant deaths, and fetal deaths are compiled by the US Vital Records System and used to monitor population health and guide health policy. The Perinatal Periods of Risk Approach (PPOR) relies on vital records data to address fetal and infant mortality in US cities. It uses reference groups to estimate preventable mortality by risk period. To avoid biased analyses due to poor data quality for small and early infant and fetal deaths, an expert committee recommended that PPOR analyses exclude fetal deaths delivered at gestational age (GA) <24 >weeks, and infant deaths and live births with birthweights (BW) …

The Effect Of Locally Applied Simvastatin On Clinical Attachment Level And Alveolar Bone In Periodontal Maintenance Patients, Lauren Krell

Theses & Dissertations

The purpose of this double-blinded, randomized, controlled trial was to determine if the local application of simvastatin (SIM), combined with minimally invasive papilla reflection and root preparation (PR/RP), is effective in improving clinical attachment level (CAL), primary outcome measure; probing depth (PD) reduction; increasing interproximal bone height (IBH); and reducing bleeding on probing (BOP) in persistent 6-9 mm periodontal pockets in patients receiving periodontal maintenance therapy (PMT). Fifty patients with Stage III, Grade B periodontitis (AAP, 2018) presenting with a 6-9 mm interproximal PD with a history of bleeding on probing (BOP) were included in the study. Experimental 2.2 mg …