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Pharmacokinetics Of Panduratin A Following Oral Administration Of A Boesenbergia Pandurata Extract To Rats, Jihyun Won, Keumhan Noh, Jae-Kwan Hwang, Beom Soo Shin, Wonku Kang

Journal of Food and Drug Analysis

Boesenbergia pandurata and its major active ingredient, panduratin A (PAN), exhibit antibacterial, anti-oxidant, anti-inflammatory, and anti-obesity effects. We explored the time course of the plasma and tissue (in the major organs, gums and skin) concentrations of PAN after oral administration of a B. pandurata extract to rats. Model-dependent analysis was used to quantify the skin distribution of PAN after systemic exposure. The PAN level peaked at 1.12 ± 0.22 μg/mL after 3 h, and then biexponentially decayed with a terminal half-life of 9 h. The mean clearance (Cl/F) was 2.33 ± 0.68 L/h/kg. The PAN levels in organs were in …

A Novel Nrf2/Are Inhibitor Gossypol Induces Cytotoxicity And Sensitizes Chemotherapy Responses In Chemo-Refractory Cancer Cells, Ya-Chu Tang, Hsin-Huei Chang, Huang-Hui Chen, Jau-Ying Yao, Yu-Tsen Chen, Yung-Jen Chuang, Jang-Yang Chang, Ching-Chuan Kuo

Journal of Food and Drug Analysis

NRF2/ARE signaling pathway is a principal regulator of cellular redox homoeostasis. The stress-induced transcription factor, NRF2, can shield cells from the oxidative damages via binding to the consensus antioxidant-responsive element (ARE) and driving several cyto-protective genes expression. Increasing evidence indicated that aberrant activation of NRF2 in malignant cells may support their survival through various pathways to detoxify chemotherapy drugs, attenuate drug-induced oxidative stress, or induce drug efflux, all of which are crucial in developing drug resistance. Accordingly, NRF2 is a potential drug target for improving the effectiveness of chemotherapy and to reverse drug resistance in cancer cells. A stable ARE-driven …

Curcumin-Induced Antitumor Effects On Triple-Negative Breast Cancer Patient-Derived Xenograft Tumor Mice Through Inhibiting Salt-Induced Kinase-3 Protein, Tzu-Chun Cheng, John Oliver Sayseng, Shih-Hsin Tu, Ting-Ching Juan, Chia-Lang Fang, You-Cheng Liao, Cheng-Ying Chu, Hui-Wen Chang, Yun Yen, Li-Ching Chen, Yuan-Soon Ho

Journal of Food and Drug Analysis

This study demonstrated for the first time that curcumin effectively inhibits the growth of triple-negative breast cancer (TNBC) tumors by inhibiting the expression of salt-induced kinase-3 (SIK3) protein in patient-derived xenografted tumor mice (TNBC-PDX). For TNBC patients, chemotherapy is the only option for postoperative adjuvant treatment. In this study, we detected the SIK3 mRNA expression in paired-breast cancer tissues by PCR analysis. The results revealed that SIK3 mRNA expression was significantly higher in tumor tissues when compared to the normal adjacent tissues (73.25 times, n=183). Thus, it is proposed for the first time that the antitumor effect induced by curcumin …

Anti-Lymphangiogenic Diterpenes From The Bark Of Calocedrus Macrolepis Var. Formosana, Tzong-Huei Lee, Chin-Lin Hsieh, Ho-Cheng Wu, Shih-Wei Wang, Chen-Lin Yu, George Hsiao, Ming-Jen Cheng, Wen-Tsong Hsieh, Yueh-Hsiung Kuo

Journal of Food and Drug Analysis

Eight new diterpenes, 6α,7β-dihydroxyferruginol (1), 6α,7α-dihydroxyferruginol (2), 6α-hydroxyhinokiol (3), 4α-hydroxy-7-oxo-18-norabieta-8,11,13-trien-4α-ol (4a), 15,16-dehydrosugiol (5), 7-methoxy-6,7-secoabieta-8,11,13-triene-6,12-diol (6), 7α-acetoxyabieta-8,12-diene-11,14-dione (7), 7α-butyloxyethyloxyabieta-8,12-diene-11,14-dione (8), along with four known compounds, 6,7-dehydroferruginol (9), 12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial (10), 7α-11-dihydroxy-12-methoxy-8,11,13-abietatriene (11), and 11,14-dihydroxy-8,11,13-abietatrien-7-one (12) were successfully isolated from the bark of Calocedrus macrolepis var. formosana. The structures of all isolates were elucidated by physical data (appearance, UV, IR, optical rotation) and spectroscopic data (1D, 2D NMR, and HREIMS). Compounds 9, 10, 11, and 12 showed promising growth-inhibitory effect on human lymphatic endothelial cells (LECs). Among these compounds, compound 10 exerted the most potent anti-lymphangiogenesis property by suppressing cell growth and …

Medicarpin Isolated From Radix Hedysari Ameliorates Brain Injury In A Murine Model Of Cerebral Ischemia, Chang-Ming Chern, Chung-Kuang Lu, Kuo-Tong Liou, Yea-Hwey Wang, Keng-Chang Tsai, Chia-Lin Chang, Chia-Che Chang, Yuh-Chiang Shen

Journal of Food and Drug Analysis

The development of effective post-stroke therapy is highly demanded. Medicarpin is a key active component of a famous Chinese herbal prescription used for post-stroke treatment in Taiwan; however, little is known about its biological effects and mechanisms of action. Herein, we implemented a murine model of cerebral ischemic/reperfusional injury-related stroke to elucidate medicarpin’s neuroprotective effect. In male ICR mice 24 h after stroke induction, treatment with medicarpin (0.5 and 1.0 mg/kg, i.v.) markedly enhanced the survival rates, improved moving distance and walking area coverage, reduced brain infarction, and preserved the blood-brain barrier, supporting medicarpin’s protective effect on stroke-induced injury. Immunohistochemistry …

In-Silico Efficacy Of Potential Phytomolecules From Ayurvedic Herbs As An Adjuvant Therapy In Management Of Covid-19, Bhanu Kumar, Ankita Misra, Satyendra Pratap Singh, Yogeshwar Vikram Dhar, Poonam Rawat, Debprasad Chattopadhyay, Saroj Kanta Barik, Sharad Srivastava

Journal of Food and Drug Analysis

The recent COVID-19 outbreak caused by SARS-CoV-2 virus has sparked a new spectrum of investigations, research and studies in multifarious directions. Efforts are being made around the world for discovery of effective vaccines/drugs against COVID-19. In this context, Ayurveda, an alternative traditional system of medicine in India may work as an adjuvant therapy in compromised patients. We selected 40 herbal leads on the basis of their traditional applications. The phytomolecules from these leads were further screened through in-silico molecular docking against two main targets of SARS-CoV-2 i.e. the spike protein (S; structural protein) and the main protease (M^{PRO …}

Conducting Polymer-Based Sensors For Food And Drug Analysis, Chia-Hsin Lin, Jia-Hui Lin, Chien-Fu Chen, Yoshihiro Ito, Shyh-Chyang Luo

Journal of Food and Drug Analysis

Conducting polymers (CPs) are a category of polymeric materials with conjugated main chains. The characteristic electrical and optical properties of CPs can be fine-tuned through controlling the doping states of CPs. Because of their long-term stability in water, CPs have been demonstrated as electroactive biointerfaces and electrode materials especially in aqueous environments. Serving as multifunctional interfaces and organic electrodes for the integration bioelectronics and devices, CPs have been studied and applied in various biological applications. This paper provides a review of conducting polymer–based electrochemical sensors, particularly those used in biological fields. General conducting polymers and derivatives and their main electrochemical …

Recent Developments In Sensing Of Oversulfated Chondroitin Sulfate In Heparin. A Review ., Manivannan Madhu, Wei-Lung Tseng

Journal of Food and Drug Analysis

Oversulfated chondroitin sulfate (OSCS), a non-natural sulfated glycosaminoglycan, recognizes as a significant containment in the pharmaceutical heparin, and it could trigger adverse reactions. Chromatography-, electrophoresis-, electrochemistry-, and spectroscopy-related techniques are currently available for accurate and precise analysis of a trace amount of OSCS in heparin. Recently, emerging studies focus on developing colorimetric and fluorescent probes to monitor OSCS containments in heparin. Therefore, this current review aims to describe the sensing principle and procedure of the reported probes that are sensitive and selective toward OSCS in heparin without the interferences of other sulfated glycosaminoglycans. The reported OSCS-specific probes are comprehensively discussed …

Florida History In Periodicals, 1983, Florida Historical Society

Florida Historical Quarterly

This selected bibliography includes scholarly articles in the fields of Florida history, archeology, geography, and anthropology published in state, regional, and national periodicals in 1983. Articles, notes, and documents which have appeared in the Florida Historical Quarterly are NOT included in this listing since they appear in the annual index of each volume. The present listing also includes articles appearing in journals not published on schedule and which were not included in the list published in the July 1983 issue of the Quarterly.

Teaching And Assessing College Stem Courses Online During Covid-19: Evidence-Based Strategies And Recommendations, Santanu De, Georgina Arguello

FDLA Journal

Since the devastating COVID-19 pandemic, most schools, colleges, and universities worldwide underwent a paradigm shift by transitioning to digital teaching and learning modalities. This phenomenon was essential to mitigate the contagion; however, the academic institutions needed to quickly come up with ways to ensure that the quality and rigor of education were maintained, especially the active and experiential learning required by undergraduate and graduate courses in science, technology, engineering, and mathematics (STEM). This paper highlights key approaches reported or proposed to effectively conduct college-level, in-person STEM courses online owing to the pandemic. These would range from synchronous versus asynchronous pedagogies …

Philosophical Foundations Of African Women's Indigenous Knowledge For Food Security: Towards Narrative Feminist Pedagogy, Humphrey Jeremiah Ojwang, Wanjiku Mukabi Kabira, Penninah Amolo Ogada

FDLA Journal

This paper explores the pedagogical value of African Women’s Indigenous Knowledge or Food Security. The approach is narratological and takes into account oral testimonies and life-stories of women farmers in Homa Bay County, Kenya. The paper proposes African feminist epistemology as a viable approach in the pedagogy of food security and agricultural extension in rural Kenya. This is a paradigm shift which incorporates women farmers’ indigenous knowledge in formal agricultural education and extension programmes. The paradigm shift to African feminist epistemology is a response to a pedagogical anomaly where women’s indigenous knowledge has been relegated to the sidelines, with hegemonic …

University Curriculum Committee Meeting Minutes - December 14, 2021, University Curriculum Committee

University Curriculum Committee Meeting Materials

Minutes for the Governors State University Curriculum Committee Meeting held December 14, 2021.

Fall Commencement Program, December 14, 2021, Coastal Carolina University

Commencement Programs

Program of Commencement Exercises at Coastal Carolina University.

Citric Acid/Β-Alanine Carbon Dots As A Novel Tool For Delivery Of Plasmid Dna Into E. Coli Cells, Anju Pandey, Asmita Devkota, Anil Sigdel, Zeinab Yadegari, C. Korsi Dumenyo, Ali Taheri

Agricultural and Environmental Sciences Faculty Research

Successful delivery of plasmid DNA into the microbial cells is fundamental in recombinant DNA technology. Natural bacterial transformation is limited to only certain species due in part to the repulsive forces between negatively charged DNA and bacterial membranes. Most common method of DNA delivery into bacteria is artificial transformation through heat shock and electroporation. These methods require sophisticated instruments and tedious steps in preparation of competent cells. Transformation by conjugation is also not applicable to all plasmids. Nanoparticles have been used successfully in therapeutics for drug delivery into animal cells. They are starting to gain popularity in plant sciences as …

University Curriculum Committee Meeting Minutes - December 14, 2021, University Curriculum Committee

Faculty Senate Minutes

Minutes for the Governors State University Curriculum Committee Meeting held December 9, 2021

Single-Cell Rna Sequencing (Scrna-Seq) Exploratory Analyses To Investigate Aging-Dependent Changes And Regional Heterogeneity In Glial Cells, Valerie N. Doze

CSB and SJU Distinguished Thesis

My thesis project research consisted of single-cell RNA-sequencing and bioinformatics using R programming and Neuroscience Multi-omic Data Archive (NeMO) Analytics to examine the impact of aging, brain region, and other variables on the genotypes and phenotypes of oligodendrocytes (OLGs) and oligodendrocyte precursor cells (OPCs). The overarching goal was to increase understanding of glial cell fate and function. After determining bioinformatical findings, follow-up wet-bench experiments were performed to validate results. RNA in situ hybridization and immunohistochemistry were performed to confirm differential gene expression across cell types and brain regions. These experiments also revealed any changes in oligodendrocyte (OLG) development and maturation …

Incarcerated People With Co-Occurring Disorders, Nikki Ketzeback

Counselor Education Capstones

People with mental illnesses are at a significantly greater risk of police arrest than the general population. This pattern of arrests has been associated with a phenomenon referred to as the criminalization of mental illness. The influence of mental health and the criminal justice system will be discussed throughout this paper. The research discussed within this paper serves as a framework for the development of a co-occurring curriculum. The curriculum developed includes components related to the overall goal of criminal justice (reducing recidivism) while addressing mental health components within a therapeutic group setting. The focus of the curriculum attached is …

National Science Foundation Awards University Of Dayton Researchers $201k To Investigate Massive Algae Blooms In Warming Arctic Ocean, Dave Larsen

College of Arts and Sciences Newsroom

The National Science Foundation awarded two University of Dayton researchers a grant to model critical changes in Arctic sea ice to detect and predict the growth and movement of large algae blooms in the Arctic Ocean, related to that region’s warming climate.

Therapeutic Potential Of Psychedelic Drugs, Specifically Magic Mushrooms, Marijuana, And Mdma With Veterans Who Suffer From Post-Traumatic Stress Disorder (Ptsd), Misty Schutterle

Counselor Education Capstones

Post-Traumatic Stress Disorder (PTSD) is a stress-based condition that a person develops after being exposed to an overwhelmingly traumatic event. Military troops frequently experience stress and trauma, making them highly susceptible to psychopathology. This paper evaluates nine clinical trials that used either magic mushrooms, marijuana, or MDMA as an adjunct to traditional psychotherapy to treat veterans who suffer from anxiety, depression, PTSD, suicidality, and other psychopathologies. Multiple scholarly journals and articles were read and analyzed, which show support for the therapeutic potential of psychedelic drugs in treating veterans with PTSD. After receiving psychedelic-assisted psychotherapy, the research showed participants experienced a …

A Na+/K+ Atpase Pump Regulates Chondrocyte Differentiation And Bone Length Variation In Mice, Marta Marchini, Mitchell R. Ashkin, Melina Bellini, Margaret Man Ger Sun, Matthew Lloyd Workentine, Hamza Malik Okuyan, Roman Krawetz, Frank Beier, Campbell Rolian

Paediatrics Publications

The genetic and developmental mechanisms involved in limb formation are relatively well documented, but how these mechanisms are modulated by changes in chondrocyte physiology to produce differences in limb bone length remains unclear. Here, we used high throughput RNA sequencing (RNAseq) to probe the developmental genetic basis of variation in limb bone length in Longshanks, a mouse model of experimental evolution. We find that increased tibia length in Longshanks is associated with altered expression of a few key endochondral ossification genes such as Npr3, Dlk1, Sox9, and Sfrp1, as well reduced expression of Fxyd2, a facultative subunit of the cell …

Effects Of Tendon Viscoelasticity On The Distribution Of Forces Across Sutures In A Model Tendon-To-Bone Repair, Yuxuan Huang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Tears to the rotator cuff often require surgical repair. These repairs often culminate in re-tearing when sutures break through the tendon in the weeks following repair. Numerous studies have been performed to identify suturing strategies that reduce this risk by balancing forces across sutures. However, the structural engineering basis for these approaches is still emerging, and the effects of tendon mechanics on load balancing is still unclear. Specifically, the effects of the viscoelastic nature of tendon on load sharing have not been established. With the aim of providing insight into this problem, this thesis studies how tendon viscoelasticity, tendon stiffness, …

Comparison Of The Transcriptomic Signatures In Pediatric And Adult Cml, Minyoung Youn, Stephanie M. Smith, Alex Gia Lee, Hee-Don Chae, Elizabeth Spiteri, Jason Erdmann, Ilana Galperin, Lara Murphy Jones, Michele Donato, Parveen Abidi, Henrique Bittencourt, Norman Lacayo, Gary Dahl, Catherine Aftandilian, Kara L. Davis, Jairo A. Matthews, Steven M. Kornblau, Min Huang, Nathan Sumarsono, Michele S. Redell, Cecilia H. Fu, I-Ming Chen, Todd A. Alonzo, Elizabeth Eklund, Jason Gotlib, Purvesh Khatri, E Alejandro Sweet-Cordero, Nobuko Hijiya, Kathleen M. Sakamoto

Pathology Research and Scholarship

Children with chronic myeloid leukemia (CML) tend to present with higher white blood counts and larger spleens than adults with CML, suggesting that the biology of pediatric and adult CML may differ. To investigate whether pediatric and adult CML have unique molecular characteristics, we studied the transcriptomic signature of pediatric and adult CML CD34+ cells and healthy pediatric and adult CD34+ control cells. Using high-throughput RNA sequencing, we found 567 genes (207 up- and 360 downregulated) differentially expressed in pediatric CML CD34+ cells compared to pediatric healthy CD34+ cells. Directly comparing pediatric and adult CML CD34+ cells, 398 genes (258 …

Student Engagement In The Honors Biology Flipped Learning Environment, Hillary M. Wilson

Doctor of Education in Instructional Technology Dissertations

The purpose of this study was to investigate four constructs of engagement (affective, behavioral, cognitive, and social) within an Honors Biology flipped learning environment. Social constructivism, the Bioecological Model of Influences on Student Engagement, and Academic Communities of Engagement (ACE) served as the theoretical foundation for the study. A mixed methods convergent parallel design was used to answer the following research questions: What are student perceptions of engagement in a flipped learning environment based on the dimensions of engagement (e.g., affective, behavioral, cognitive, and social)? How do high school Honors biology students affectively, behaviorally, cognitively, and socially engage during the …

Stick It: The Lasting Experiences Of Gymnasts, Jason Gibbons

Final Projects

About the experiences of gymnasts. This paper highlights the importance of mindful coaching tactics and comradery in the face of difficult situations.

Bet You Won't Guess My Middle Name: Middle Name Customs In Lds Culture, Kayla Rane

Final Projects

About the Latter-day Saint tradition of withholding a daughter's middle name. Includes interviews about women who legally adopted their maiden name as a middle name upon marriage.

Polatuzumab Vedotin In Previously Untreated Diffuse Large B-Cell Lymphoma, Hervé Tilly, Neha Mehta-Shah, Et Al

Open Access Publications

BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is typically treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). However, only 60% of patients are cured with R-CHOP. Polatuzumab vedotin is an antibody-drug conjugate targeting CD79b, which is ubiquitously expressed on the surface of malignant B cells.

METHODS: We conducted a double-blind, placebo-controlled, international phase 3 trial to evaluate a modified regimen of R-CHOP (pola-R-CHP), in which vincristine was replaced with polatuzumab vedotin, as compared with standard R-CHOP, in patients with previously untreated intermediate-risk or high-risk DLBCL. Patients 18 to 80 years of age were randomly assigned in a 1:1 ratio to …

Active Targeting Of Estrogen Receptor (Er)-Positive Breast Cancer Cells Using Nanotechnology, Molly White

Theses and Dissertations

The American Cancer Society has predicted an estimated 281,550 new invasive breast cancer cases for 2021. Chemotherapy is one of the main options available to treat this disease, but it can result in drug resistance and harmful side effects, as traditional methods do not directly target the cancer cells. To address this issue, nano formulations have been widely researched for targeted delivery of anticancer drugs. The primary objective of this project was to develop a novel nanodrug, rapamycin-loaded gold nanorods functionalized with polyethylene glycol and epithelial cell adhesion molecule (EpCAM), to selectively target breast cancer cells. The work involved characterizing …

Microfluidic-Coupled In Vitro Model Of The Blood-Brain Barrier, Subhra Mohapatra, Shyam S. Mohapatra, Tao Wang, Taylor Martinez

USF Patents

An in vitro microfluidic device includes a device configured to model a blood-brain barrier. The device includes a center well in fluidic communication with each of an inlet and an outlet. Each of the center well, inlet, and outlet includes a porous membrane that separates a “blood” portion (a fluid flow portion) from a “brain” portion (a fluid containing portion). The porous membrane is seeded with endothelial cells such as the human venule endothelial cells (HUVECs) on the blood side, and with astrocytes on the brain side, to accurately model the blood-brain barrier. Fluid flows between the inlet, the center …

A Comparison Of The Risk Of Fracture In Rheumatoid Arthritis Patients With And Without Receiving Chinese Herbal Medicine, Hou-Hsun Liao, Hanoch Livneh, Yu-Jung Chung, Ching-Hsing Lin, Ning-Sheng Lai, Hung-Rong Yen, Tzung-Yi Tsai

Counselor Education Faculty Publications and Presentations

Objective: Patients with rheumatoid arthritis (RA) often suffer from bone complications due to persistent joint inflammation, especially incident fracture. Nowadays, Chinese herbal medicines (CHMs) have provided safe and effective therapy for treating skeletal conditions, but it is unclear whether CHMs can prevent fracture onset among RA individuals. This study aimed to determine the association between the use of CHMs and the risk of fracture among them.

Methods: This retrospective, population-based study retrieved administrative health data from the Taiwan National Health Insurance (NHI) database to identify patients with newly diagnosed RA between 2000 and 2009. Of the 6178 incident …

Disinheritance, Discrimination, And The Case For Including Adult Independent Children In Dependants’ Relief Schemes: Lawen Estate V Nova Scotia, Jane Thomson

Dalhousie Law Journal

In 2019 a Superior Court in Nova Scotia excluded adult independent children as “Dependants” under Nova Scotia’s Testator’s Family Maintenance Act. The decision was based on a finding that testamentary autonomy is a constitutional right protected by s. 7 of Canada’s Charter of Rights and Freedoms. This article explains why the constitutional decision in Lawen Estate v Nova Scotia was incorrect. It also demonstrates why the inclusion of adult independent children in dependants’ relief schemes is not only benign in most instances, but may play a role in preventing the perpetuation of discrimination in the private law. This article also …