Digital Commons Network^™

Graphene Transistor-Based Printable Electronics For Wearable Biosensing Applications, Kaitlyn Laliberte

Master's Theses and Capstones

Graphene field-effect transistor (GFET) is becoming an increasingly popular biosensing platform for monitoring health conditions through biomarker detection. Moreover, the graphene’s 2-dimensional geometry makes it ideal for implementing flexible or wearable electronic devices. By using a GFET platform as a biosensor, users can easily monitor numerous health conditions. A sweat-based biosensor can non-invasively monitor levels of proteins in the body and alert the user to possible issues such as a steep increase or decrease in a particular protein. By creating a platform that can be used as a wearable biosensor, it allows for rapid results and a cheaper way to …

The Role Of Stat3 In Cisplatin Resistant Ovarian Cancer, Sarah Miseirvitch

Master's Theses and Capstones

According to the American Cancer Society, approximately 21,410 women will receive a diagnosis of ovarian cancer, and 13,770 women will die from ovarian cancer in 2021. Typically, ovarian cancer is not diagnosed until it has reached stage III/IV in its progression. By later stages of disease, an ovarian cancer tumor has migrated to the peritoneum, existing either in single cell or spheroid form, and resulting in inflammation and buildup of ascites fluid, and metastasis of secondary tumors. Ascites fluid is comprised of many different secreted extracellular matrix (ECM) molecules, proteases and cytokines. The cytokine IL-6 is abundant in ascites fluid …

The Effect Of Wood-Fiber Substrates On Natural Disease Suppression And The Efficacy Of Rootshield®Wp Against Rhizoctonia Solani, Isobel Michaud

Master's Theses and Capstones

As by-products of the forest industry, wood fibers (WFs) are affordable and sustainable raw materials that have risen in popularity in the last decade to help meet the demand for soilless substrates. Wood fibers are high in hemicellulose and cellulose content yet have lower lignin content than Sphagnum peat, coconut coir, and tree bark-based growing medium components. Researchers have demonstrated that wood is more microbially active than peat and that WFs from pine and poplar have significantly greater fungal diversity and abundance than peat and coir, which can have higher bacterial diversity than WFs. However, the effects of WF-associated microbial …

The Theory Of Multiple Intelligences In A Special Education Music Classroom, Daniel Passadino

Masters Theses

Special education students involved in music classes currently face a lack of inclusivity. Various methods have been used to promote inclusivity in the music classroom. This paper focuses on how Howard Gardner’s multiple intelligence theory promotes inclusivity in the special education music classroom. The multiple intelligence theory streamlines a special education music curriculum by highlighting each child’s strongest intelligence. To assess a child’s intelligences, they must participate in music-related tests. The tests include mini lessons which cater to the multiple intelligences. For example, when children are taught using visuals, some will not be able to learn as effectively if they …

Developmental Histories Facilitating The Emergence Of Creative Scientific Expertise: The Role Of Developed Cognitive Talents, Education, And Social And Cultural Contexts, Jonathan Wai, Matt I. Brown

Education Reform Faculty and Graduate Students Publications

Understanding how individual and contextual factors collectively contribute to the developmental histories that facilitate the emergence of creative expertise in science is improved by considering the contribution of the broad structure of developed cognitive abilities to creativity, prospective research on the high achieving or gifted students who may choose careers in and end up as creative scientists later in life, as well as retrospective studies of established creative scientists themselves and what their educational histories reveal. We first review and elaborate on these connections as documented in research which explore the development of talent, including cognitive mechanisms that include math …

Single-Cell Analysis Of The Neonatal Immune System Across The Gestational Age Continuum, Laura S. Peterson, Julien Hedou, Edward Ganio, Ina A. Stelzer, Dorien Feyaerts, Eliza Harbert, Yamini Adusumelli, Kazuo Ando, Eileen S. Tsai, Amy S. Tsai, Xiaoyuan Han, Megan Ringle, Pearl Houghteling, Jonathan Reiss, David Lewis, Virginia D. Winn, Martin S. Angst, Nima Aghaeepour, David K. Stevenson, Brice Gaudilliere

All Dugoni School of Dentistry Faculty Articles

Although most causes of death and morbidity in premature infants are related to immune maladaptation, the premature immune system remains poorly understood. We provide a comprehensive single-cell depiction of the neonatal immune system at birth across the spectrum of viable gestational age (GA), ranging from 25 weeks to term. A mass cytometry immunoassay interrogated all major immune cell subsets, including signaling activity and responsiveness to stimulation. An elastic net model described the relationship between GA and immunome (R=0.85, p=8.75e-14), and unsupervised clustering highlighted previously unrecognized GA-dependent immune dynamics, including decreasing basal MAP-kinase/NFkB signaling in antigen presenting cells; increasing responsiveness of …

Efficient Killing Of Tumor Cells By Car-T Cells Requires Greater Number Of Engaged Cars Than Tcrs, Nadia Anikeeva, Sergey Panteleev, Nicholas W Mazzanti, Mizue Terai, Takami Sato, Yuri Sykulev

Department of Microbiology and Immunology Faculty Papers

Although CAR-T cells are widely used to treat cancer, efficiency of CAR-T cell cytolytic responses has not been carefully examined. We engineered CAR specific for HMW-MAA (highmolecular- weight melanoma-associated antigen) and evaluated potency of CD8+ CAR-T cells to release cytolytic granules and to kill tissue-derived melanoma cells, which express different levels of HMW-MAA. CAR-T cells efficiently killed melanoma cells expressing high level of HMW-MAA, but not melanoma cells with lower levels of HMW-MAA. The same melanoma cells presenting significantly lower level of stimulatory peptide- MHC ligand were readily lysed by T cells transduced with genes encoding α,β-TCR specific for the …

Aripiprazole Lauroxil, A Novel Injectable Long-Acting Antipsychotic Treatment For Adults With Schizophrenia: A Comprehensive Review, Kunal Maini, Haley Gould, Jessica Hicks, Fatima Iqbal, James Patterson, Amber N. Edinoff, Elyse M. Cornett, Adam M. Kaye, Omar Viswanath, Ivan Urits, Alan David Kaye

School of Pharmacy Faculty Articles

Purpose of Review. This is a comprehensive review of the literature regarding the use of Aripiprazole lauroxil for schizophrenia. This review presents the background, evidence, and indications for using aripiprazole lauroxil to treat schizophrenia in the context of current theories on the development of schizophrenia. Recent Findings. Schizophrenia is a chronic mental health disorder that currently affects approximately 3.3 million people in the United States. Its symptoms, which must be present for more than six months, are comprised of disorganized behavior and speech, a diminished capacity to comprehend reality, hearing voices unheard by others, seeing things unseen by others, delusions, …

Wild 370.00: Wildlife Habitat Conservation, Marcel P. Huijser

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Professor Jerry Gaff Oral History Transcript, Jerry Gaff, Tom Preece

Raymond College

No abstract provided.

Linking Ecomechanical Models And Functional Traits To Understand Phenotypic Diversity, Timothy E. Higham, Lara A. Ferry, Lars Schmitz, Duncan J. Irschick, Samuel Starko, Philip S.L. Anderson, Philip J. Bergmann, Heather A. Jamniczky, Leandro R. Monteiro, Dina Navon, Julie Messier, Emily Carrington, Stacy C. Farina, Kara L. Feilich, L. Patricia Hernandez, Michele A. Johnson, Sandy M. Kawano, Chris J. Law, Sarah J. Longo, Christopher H. Martin, Patrick T. Martone, Alejandro Rico-Guevara, Sharlene E. Santana, Karl J. Niklas

Biology

Physical principles and laws determine the set of possible organismal phenotypes. Constraints arising from development, the environment, and evolutionary history then yield workable, integrated phenotypes. We propose a theoretical and practical framework that considers the role of changing environments. This ‘ecomechanical approach’ integrates functional organismal traits with the ecological variables. This approach informs our ability to predict species shifts in survival and distribution and provides critical insights into phenotypic diversity. We outline how to use the ecomechanical paradigm using drag-induced bending in trees as an example. Our approach can be incorporated into existing research and help build interdisciplinary bridges. Finally, …

Bioremediation Potential Of Chlorella Vulgaris And Nostoc Paludosum On Azo Dyes With Analysis Of Metabolite Changes, Olfat M.A. Salem, Asmaa Abdelsalam, Arezue Boroujerdi

Baghdad Science Journal

Microalgae have been used widely in bioremediation processes to degrade or adsorb toxic dyes. Here, we evaluated the decolorization efficiency of Chlorella vulgaris and Nostoc paludosum against two toxic dyes, crystal violet (CV) and malachite green (MG). Furthermore, the effect of CV and MG dyes on the metabolic profiling of the studied algae has been investigated. The data showed that C. vulgaris was most efficient in decolorization of CV and MG: the highest percentage of decolorization was 93.55% in case of MG, while CV decolorization percentage was 62.98%. N. paludosum decolorized MG dye by 77.6%, and the decolorization percentage of …

Reckless Parenting With A Purpose, Walter H. Piper, Linda Grenzer

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

No abstract provided.

Spontaneous Fluctuations In A Magnetic Fe/Gd Skyrmion Lattice, M. H. Seaberg, B. Holladay, S. A. Montoya, X. Y. Zheng, J. C.T. Lee, A. H. Reid, J. D. Koralek, L. Shen, V. Esposito, G. Coslovich, P. Walter, S. Zohar, V. Thampy, M. F. Lin, P. Hart, K. Nakahara, R. Streubel, S. D. Kevan, P. Fischer, W. Colocho, A. Lutman, F. J. Decker, E. E. Fullerton, M. Dunne, S. Roy, S. K. Sinha, J. J. Turner

Robert Streubel Papers

Magnetic skyrmions are topological spin textures that exhibit classical or quantum quasiparticle behavior. A substantial amount of research has occurred in this field, both because of their unique electromagnetic properties and potential application for future nonvolatile memory storage applications, as well as fundamental questions on their topology and unique magnetic phases. Here, we investigate the fluctuation properties of a magnetic Fe/Gd skyrmion lattice, using short-pulsed x rays. We first measure spontaneous fluctuations of the skyrmion lattice phase and find an inherent, collective mode showing an underdamped oscillation with a relaxation of a couple of nanoseconds. Further observations track the response …

Cross-Sectional Analysis Of Baseline Visual Parameters In Subjects Recruited Into The Rescue And Reverse Nd4-Lhon Gene Therapy Studies, Mark Moster, Robert C Sergott, Nancy J Newman, Patrick Yu-Wai-Man, Valerio Carelli, Molly Scannell Bryan, Gerard Smits, Valérie Biousse, Catherine Vignal-Clermont, Thomas Klopstock, Alfredo A Sadun, Adam A. Debusk, Michele Carbonelli, Rabih Hage, Siegfried Priglinger, Rustum Karanjia, Laure Blouin, Magali Taiel, Barrett Katz, José Alain Sahel

Wills Eye Hospital Papers

OBJECTIVE: This report presents a cross-sectional analysis of the baseline characteristics of subjects with Leber hereditary optic neuropathy enrolled in the gene therapy trials RESCUE and REVERSE, to illustrate the evolution of visual parameters over the first year after vision loss.

METHODS: RESCUE and REVERSE were 2 phase III clinical trials designed to assess the efficacy of rAAV2/2-ND4 gene therapy in ND4-LHON subjects. At enrollment, subjects had vision loss for ≤6 months in RESCUE, and between 6 and 12 months in REVERSE. Functional visual parameters (best-corrected visual acuity [BCVA], contrast sensitivity [CS], and Humphrey Visual Field [HVF]) and structural parameters …

Long-Term Follow-Up After Unilateral Intravitreal Gene Therapy For Leber Hereditary Optic Neuropathy: The Restore Study, Valérie Biousse, Nancy J Newman, Patrick Yu-Wai-Man, Valerio Carelli, Mark Moster, Catherine Vignal-Clermont, Thomas Klopstock, Alfredo A Sadun, Robert C Sergott, Rabih Hage, Simona Esposti, Chiara La Morgia, Claudia Priglinger, Rustum Karanja, Laure Blouin, Magali Taiel, José-Alain Sahel

Wills Eye Hospital Papers

BACKGROUND: RESCUE and REVERSE were 2 Phase 3 clinical trials that assessed the efficacy and safety of intravitreal gene therapy with lenadogene nolparvovec (rAAV2/2-ND4) for the treatment of Leber hereditary optic neuropathy (LHON). RESTORE is the long-term follow-up study of subjects treated in the RESCUE and REVERSE trials.

METHODS: In RESCUE and REVERSE, 76 subjects with LHON because of the m.11778 G>A mutation in the mitochondrial gene ND4 received a single unilateral intravitreal injection of lenadogene nolparvovec. After 96 weeks, 61 subjects were enrolled in the long-term follow-up study RESTORE. The best-corrected visual acuity (BCVA) was assessed over a …

Plague Exposure In Mammalian Wildlife Across The Western United States, Sarah N. Bevins, Jeffrey C. Chandler, Nicole Barrett, Brandon S. Schmit, Gerald W. Wiscomb, Susan A. Shriner

United States Department of Agriculture Wildlife Services: Staff Publications

Plague is caused by a bacterial pathogen (Yersinia pestis) that can infect a wide range of mammal species, but its presence in wildlife is often underappreciated. Using a large-scale data set (n = 44,857) that details the extent of Y. pestis exposure in wildlife, we document exposure in 18 wildlife species, including coyotes (Canis latrans), bobcats (Lynx rufus), and black bears (Ursus americanus). Evidence of plague activity is widespread, with seropositive animals detected in every western state in the contiguous United States. Pathogen monitoring systems in wildlife that are both large scale …

Data-Driven Management—A Dynamic Occupancy Approach To Enhanced Rabies Surveillance Prioritization, Amy J. Davis, Jordana D. Kirby, Richard B. Chipman, Kathleen M. Nelson, Amy T. Gilbert

United States Department of Agriculture Wildlife Services: Staff Publications

Rabies lyssavirus (RABV) is enzootic in raccoons across the eastern United States. Intensive management of RABV by oral rabies vaccination (ORV) has prevented its spread westward and shown evidence of local elimination in raccoon populations of the northeastern US. The USDA, Wildlife Services, National Rabies Management Program (NRMP) collaborates with other agencies to implement broad-scale ORV and conducts extensive monitoring to measure the effectiveness of the management. Enhanced Rabies Surveillance (ERS) was initiated during 2005 and updated in 2016 to direct surveillance efforts toward higher-value specimens by assigning points to different methods of encountering specimens for collection (strange-acting, roadkill, surveillance-trapped, …

Clinical Practice Guidelines For Liver Transplantation In Saudi Arabia, Faisal A. Abaalkhail, Mohammed A. Shagrani, Wael A. O’Hali, Nasser M. Almasri, Abduljaleel A. Alalwan, Mohammed Y. Alghamdi, Hamad Al-Bahili, Mohammed S. Alqahtani, Saleh I. Alabbad, Waleed K. Al-Hamoudi, Saleh A. Alqahtani

Saudi Medical Journal

The demand for liver transplantation in the Kingdom of Saudi Arabia (KSA) is associated with the country’s high burden of liver disease. Trends in the epidemiology of liver transplantation indications among recipients in KSA have changed over 20 years. Non-alcoholic steatohepatitis has eclipsed the hepatitis C virus in the country due to the effective treatment strategies for HCV. Risk factors for NASH, like type 2 diabetes mellitus, obesity, and hyperlipidemia, are becoming a major concern and a leading indication for liver transplantation in the KSA. There is also a significantly increased prevalence and incidence of genetic adult familial liver diseases …

Who Statement On Advancing The Next Series Of Studies To Find The Origins Of Sars-Cov-2

Saudi Medical Journal

No abstract provided.

Predicting Long-Term Hepatocellular Carcinoma Response To Transarterial Radioembolization Using Contrast-Enhanced Ultrasound: Initial Experiences., Lauren J. Delaney, M. Tantawi, Corinne Wessner, Priscilla Machado, Flemming Forsberg, Andrej Lyshchik, Patrick O'Kane, Ji-Bin Liu, Jesse M. Civan, Alison Tan, Kevin Anton, Colette Shaw, John R. Eisenbrey

Department of Radiology Faculty Papers

Conventional cross-sectional imaging done shortly after radioembolization of hepatocellular carcinoma (HCC) does not reliably predict long-term response to treatment. This study evaluated whether quantitative contrast-enhanced ultrasound (CEUS) can predict the long-term response of HCC to yttrium-90 (Y-90) treatment. Fifteen patients underwent CEUS at three time points: immediately following treatment and 1 and 2 wk post-treatment. Response 3-6 mo after treatment was categorized on contrast-enhanced magnetic resonance imaging by two experienced radiologists using the Modified Response Evaluation Criteria in Solid Tumors. CEUS data were analyzed by quantifying tumor perfusion and residual fractional vascularity using time-intensity curves. Patients with stable disease on …

Complete Mitochondrial Genome Sequence Of The Gulf Coast Tick (Amblyomma Maculatum), Amanda E. Brenner, Rahul Raghavan

Biology Faculty Publications and Presentations

The complete circularized mitochondrial genome sequence of Amblyomma maculatum is 14,803 bp long. It encodes 13 protein coding genes, 2 rRNA genes, 22 tRNA genes, 2 tick box motifs, and 2 control regions. The gene arrangement and content are consistent with those of previously reported Metastriata tick mitochondrial genomes.

Cryptosporidium Spp. Diagnosis And Research In The 21st Century, Jennifer K. O'Leary, Roy D. Sleator, Brigid Lucey

Department of Biological Sciences Publications

The protozoan parasite Cryptosporidium has emerged as a leading cause of diarrhoeal illness worldwide, posing a significant threat to young children and immunocompromised patients. While endemic in the vast majority of developing countries, Cryptosporidium also has the potential to cause waterborne epidemics and large scale outbreaks in both developing and developed nations. Anthroponontic and zoonotic transmission routes are well defined, with the ingestion of faecally contaminated food and water supplies a common source of infection. Microscopy, the current diagnostic mainstay, is considered by many to be suboptimal. This has prompted a shift towards alternative diagnostic techniques in the advent of …

Odor-Evoked Increases In Olfactory Bulb Mitral Cell Spiking Variability, Cheng Ly, Andrea K. Barreiro, Shree Hari Gautam, Woodrow L. Shew

Physics Faculty Publications and Presentations

The spiking variability of neural networks has important implications for how information is encoded to higher brain regions. It has been well documented by numerous labs in many cortical and motor regions that spiking variability decreases with stimulus onset, yet whether this principle holds in the OB has not been tested. In stark contrast to this common view, we demonstrate that the onset of sensory input can cause an increase in the variability of neural activity in the mammalian OB. We show this in both anesthetized and awake rodents. Furthermore, we use computational models to describe the mechanisms of this …

Addressing And Inspiring Vaccine Confidence In Black, Indigenous, And People Of Color During The Coronavirus Disease 2019 Pandemic, Jasmine R Marcelin, Talia H Swartz, Fidelia Bernice, Vladimir Berthaud, Robbie Christian, Christopher Da Costa, Nada Fadul, Michelle Floris-Moore, Matifadza Hlatshwayo, Patrik Johansson, Ravina Kullar, Kimberly Manning, Edo-Abasi U. Mcgee, Christopher Medlin, Damani A Piggott, Uzma Syed, Jessica Snowden, Tina Tan, Jacinda C Abdul-Mutakabbir

PCOM Scholarly Works

During the coronavirus disease 2019 (COVID-19) pandemic, we have witnessed profound health inequities suffered by Black, Indigenous, and People of Color (BIPOC). These manifested as differential access to testing early in the pandemic, rates of severe disease and death 2-3 times higher than white Americans, and, now, significantly lower vaccine uptake compared with their share of the population affected by COVID-19. This article explores the impact of these COVID-19 inequities (and the underlying cause, structural racism) on vaccine acceptance in BIPOC populations, ways to establish trustworthiness of healthcare institutions, increase vaccine access for BIPOC communities, and inspire confidence in COVID-19 …

Bios 594.01: Systems Ecology Graduate Student Seminar, Benjamin P. Coleman

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Fors 333.01: Fire Ecology, Kyra D. Wolf

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Fors 349.00: Practice Of Silviculture, John M. Goodburn

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Fors 538.01: Statistical Models For Ecological Data Analysis, Solomon Z. Dobrowski

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Nrsm 389e.00: Ethics & Sustainability, N. Dane Scott

University of Montana Course Syllabi, 2021-2025

No abstract provided.