Digital Commons Network^™

Tools And Strategies For The Patterning Of Bioactive Molecules And Macromolecules, Daniel J. Valles

Dissertations, Theses, and Capstone Projects

Hypersurface Photolithography (HP) is a printing method for fabricating structures and patterns composed of soft materials bound to solid surfaces and with ~1 micrometer resolution in the x, y, and z dimensions. This platform leverages benign, low intensity light to perform photochemical surface reactions with spatial and temporal control of irradiation, and, as a result, is particularly useful for patterning delicate organic and biological material. In particular, surface- initiated controlled radical polymerizations can be leveraged to create arbitrary polymer and block- copolymer brush patterns. Chapter 1 will review the advances in instrumentation architectures from our group that have made these …

Connecting Communities To Coastal Resilience: Enhancing Sustainability Through Public Participation In Salt Marsh Management And Restoration In Suffolk County, Ny, Jennifer L. Mcgivern

Dissertations, Theses, and Capstone Projects

Coastal resiliency is becoming significantly more critical to the livelihood of coastal communities as the frequency and intensity of storm events increases and is exacerbated by rising sea levels due to climate change. In October 2012 Superstorm Sandy impacted the New York-New Jersey area costing over $70 billion in storm damages and 147 lives lost, as storm surges surpassed record highs for the region. Protruding more than 100 miles into the Atlantic Ocean with over 1,000 miles of shoreline, Long Island is particularly vulnerable to the increasingly ferocious and numerous storms as well as the rising sea levels that climate …

Contributions Of Reward Identity And Time Prediction Errors To Pavlovian Learning, Daniel B. Siegel

Dissertations, Theses, and Capstone Projects

Some models of associative learning attempt to explain effects such as blocking and unblocking as reflecting a prediction error (PE): Associative strength, and thereby learning, are said to be greater when the unconditioned stimulus (US) received following a cue deviates from one’s expectations. Some models of PE-motivated behavior and PE-relevant brain activity represent the US as a single quantitative variable for outcome value, and that learning therefore only occurs when outcome value differs from expectations. There is growing evidence to suggest that changes in other dimensions of reward, such as identity and timing, also contribute to learning. In Experiment 1, …

Some Notes On Birds: Language And Attention In The Age Of Social Media, Aimee Lamoureux

Dissertations, Theses, and Capstone Projects

Technology, social media, and its affiliated distractions are now an ever-present part of our daily lives. Attention is a commodity, one which tech companies value because it delivers them bigger and bigger profits. Their products are intentionally designed to be additive, to demand more and more of our time and attention throughout our day. However, attention is not simply a commodity, but the way in which we connect with the external world and attend to our everyday experience. The world that we create in the mind is the world that ends up forming the reality of our everyday lives. Complex …

Evaluating The Role Of Gender In Dementia-Related Language Deficiencies, Kelsey Bourque

Dissertations, Theses, and Capstone Projects

Typically, about 60% of dementia patients are women. Researchers have historically dismissed this imbalance as a result of the life expectancy for women being longer, and since age is the primary risk factor associated with dementia, and women’s longer lifespan equates to a higher percentage of the dementia patient population (Mielke, 2018). While the exact cause of dementia is unknown, researchers and clinicians have historically treated male and female populations the same, asserting that there is no significant difference between the two sexes in regards to detecting dementia. The present study aims to address this potential gap in dementia research, …

“Woman’S Legitimate Empire”: Fabricating Asianness In Gaskell’S North And South And Mary Elizabeth Braddon’S Lady Audley’S Secret, Hailey Lam

Dissertations, Theses, and Capstone Projects

This thesis argues that the fabrication of Asianness in Victorian literature is indebted to the subtle, yet frequent gestures, habits, and interactions that occur in the literary works of Elizabeth Gaskell and Mary Elizabeth Braddon. By specifically focusing on Gaskell’s North and South (1855) and Braddon’s Lady Audley’s Secret (1862), I explore a methodological approach for literary studies that is capacious enough to reckon with the material histories and materiality of race that pervade the cultural imagination of an eighteenth and nineteenth century England. Queer of color criticism by scholars like Sara Ahmed and meditations on aesthetics, race, and culture …

The Effect Of Speaking Rate On Vowel Variability Based On The Uncontrolled Manifold Approach And Flow-Based Invertible Neural Network Modeling, Jaekoo Kang

Dissertations, Theses, and Capstone Projects

Variability is intrinsic to human speech production. One approach to understand variability in speech is to decompose it into task-irrelevant (“good”) and task-relevant (“bad”) parts with respect to speech tasks. Based on the uncontrolled manifold (UCM) approach, this dissertation investigates how vowel token-to-token variability in articulation and acoustics can be decomposed into “good” and “bad” parts and how speaking rate changes the pattern of these two from the Haskins IEEE rate comparison database. Furthermore, it is examined whether the “good” part of variability, or flexibility, can be modeled directly from speech data using the flow-based invertible neural networks framework. The …

Food-As-Medicine: An Everyday Strategy Of Health, Rachel Rebecca Bogan

Dissertations, Theses, and Capstone Projects

Using food-as-medicine, a valuable strategy of health, as its focus, this dissertation examines why and how New Yorkers use food to negotiate their health. I argue that while using food medicinally is a common health practice, food-as-medicine operates unequally among different groups of New Yorkers. I attribute this inequity, in part, to how those in power, including public health experts, biomedical doctors, and the food industry, operationalize food-as-medicine as a health remedy and to a neoliberal, healthist context that ties people’s morally “correct” uses of food-as-medicine to their abilities to access “good” citizenship and optimal health.

I chose to write …

Study Of The Gain-Of-Function Mutant P53 And Parp1 In Triple-Negative Breast Cancer, Devon Lundine

Dissertations, Theses, and Capstone Projects

Cancer cells often lose expression of the p53 protein or express mutant forms of p53. Some of these mutant p53 proteins, called gain-of-function mutant p53, have gained oncogenic functions. Previously, our group observed mutant p53 R273H interacts with replicating DNA and upregulates the chromatin localization of several DNA replication factors including PCNA, MCM2-7, and PARP1 (termed the mtp53-PARP-MCM axis). In this thesis, we explore the contribution of mutant p53 and PARP1 in castration-resistant prostate cancer (mutant p53 P223L and V274F) and triple-negative breast cancer (mutant p53 R273H). In the castration-resistant prostate cancer cell line DU145, we examine two mutant p53 …

Connect Or Protect: The Impact Of Ghosting On Potential Partner Perception And Pursuit, Maureen Coyle

Dissertations, Theses, and Capstone Projects

As an increasing number of individuals seek meaningful connections in online dating, it is important to understand how online dating users’ perceptions and behaviors vary because of contact being terminated with them without warning (i.e., being ghosted) and their regulatory focus. Research on how being ghosted affects users’ expectations and pursuit of potential partners is limited, despite ghosting being a pervasive online dating experience. Also, the role of users’ motivational systems of goal pursuit, namely regulatory focus (promotion focus: motive to affiliate/connect with others, prevention focus: motive to avoid rejection/protect the self), on users’ expectations and pursuit of potential partners …

Adversarial Training For Skill Learning In A Mobile Robot, Todd W. Flyr

Dissertations, Theses, and Capstone Projects

Machine Learning in mobile robotics is sometimes hampered by the difficulties associated with the creation of a large corpus of labeled data that most neural network based learning algorithms demand. In recent years, advances in the field of machine learning have been facilitated via the creation of large collaboratively-created labeled training datasets that researchers can use as the basis for experiments to validate and improve their candidate neural network architectures. For the field of robotics, however, tasks are so disparate and the physical devices so varied that in most cases the creation of collaborative benchmark datasets are impractical. Obtaining data …

Pilot Study Of The Effects Of Mobile Based Resonant Frequency Breathing On Cognitive Performance In Healthy Young Adults With Elevated Stress, Daniel Saldana

Dissertations, Theses, and Capstone Projects

Objective: Prior research has shown a bidirectional relationship between breathing, emotions, behavior, and cognitive functions thought to be mediated by the autonomic nervous system (ANS). Studies have shown that deep or diaphragmatic breathing interventions are associated with improved affect and decreased stress levels, but little attention has been paid to the effects of breathing training on cognition. The few studies that have looked at this have shown improved attention, memory, and executive functioning as a result of breathing interventions. While suggestive of positive benefits, these studies used control groups that are either inactive or inappropriate for determining their respective mechanisms …

The Effect Of Psilocybin On Personality, Ravital Labua

Dissertations, Theses, and Capstone Projects

As classic psychedelics are increasingly legalized and reintroduced into the psychotherapeutic frame, a deeper understanding of their effect on personality and overall wellbeing - as well as their clinical contraindications and potential pitfalls - will prove essential. As a result, this study represents a preliminary investigation into the effect of psilocybin exposure on a range of personality constructs.

Methods: Data was collected through a collaboration with The Psychedelic Society, an organization that legally administers psilocybin truffles in the Netherlands to self-selecting retreat attendees who have been screened for mental health disorders in accordance with Johnson et al.’s (2008) widely accepted …

Gendering The Virtual Space: Sonic Femininities And Masculinities In Contemporary Top 40 Music, Michèle Duguay

Dissertations, Theses, and Capstone Projects

This dissertation analyzes vocal placement—the apparent location of a voice in the virtual space created by a recording—and its relationship to gender. When listening to a piece of recorded music through headphones or stereo speakers, one hears various sound sources as though they were located in a virtual space (Clarke 2013). For instance, a specific vocal performance—once manipulated by various technologies in a recording studio—might evoke a concert hall, an intimate setting, or an otherworldly space. The placement of the voice within this space is one of the central musical parameters through which listeners ascribe cultural meanings to popular music. …

The Structural And Functional Role Of Photosensing In Rgs-Lov Proteins, Zaynab Jaber

Dissertations, Theses, and Capstone Projects

Light provides organisms with energy and spatiotemporal information. To survive and adapt, organisms have developed the ability to sense light to drive biochemical effects that underlie vision, entrainment of circadian rhythm, stress response, virulence, and many other important molecularly driven responses. Blue-light sensing Light-Oxygen-Voltage (LOV) domains are ubiquitous across multiple kingdoms of life and modulate various physiological events via diverse effector domains. Using a small molecule flavin chromophore, the LOV domain undergoes light-dependent structural changes leading to activation or repression of these catalytic and non-catalytic effectors. In silico analyses of high-throughput genomic sequencing data has led to the marked expansion …

Analysis Of Transplantable Photoreceptor Replacement Cell Chemotactic Mechanisms In Retinal Biomimetic Ligand Gradients, Onyekwere Onwumere

Dissertations, Theses, and Capstone Projects

Disease or trauma induced loss of rod and cone photoreceptors is a major cause of vision loss worldwide. To replace lost photoreceptors and restore vision, laboratories around the world are investigating photoreceptor replacement strategies using subretinal injection of photoreceptor precursor cells (PPCs) and retinal progenitor cells (RPCs). A major obstacle in the field is that transplanted photoreceptor replacement cells exhibit extremely limited migration into host retina following injection into the subretinal space. In this work, we show that PPCs and host retinal interaction bioinformatics modeling can identify key pathways involved in photoreceptor replacement cell migration and invasion behaviors. In addition, …

Between Occitania And Al-Andalus: Reconsidering The Emergence Of Troubadour Melody Through Algorithmic Analysis, Veronica Maria Da Rosa Guimaraes

Dissertations, Theses, and Capstone Projects

How the musical and poetic traditions of the troubadours arose remains unknown, despite a century of scholarship that has attempted to account for their seemingly ex nihilo appearance in late twelfth-century Europe. Scholarly debate was particularly intense during the first half of the twentieth century and revolved around two competing theories: the Andalusi theory, which linked the troubadours to the poetic-musical traditions of medieval Muslim Iberia (also known by its Arabic name al-Andalus), and the Aquitanian theory, which argued that the troubadours were rooted in the folk and sacred traditions of the Aquitanian region. Since the 1980s, interest in the …

The Role Of Estrogen Receptor Alpha In Regulating Messenger Rna 3’ End Processing And Controlling Gene Expression In Breast Cancer Cells, Sophia Varriano

Dissertations, Theses, and Capstone Projects

Estrogen signaling regulates various physiological processes within the female reproductive, cardiovascular, immune, and central nervous systems and is predominantly mediated by estrogen receptors (ER), ERα and ERβ. Transcriptional regulation by ERs has been widely studied, where activated ERs bind either directly to target genes through binding to estrogen response elements or indirectly through interacting with other proteins, resulting in changes in gene expression. However, the potential role of factors involved in the estrogen signaling pathway in posttranscriptional regulation has not been extensively documented. As 70-80% of breast cancers (BCs) are identified as ER(+), studying how these factors, particularly ERα, regulates …

How Frustration Impacts The Relationship Between Potential For Child Physical Abuse Perpetration And Emotion Processing, Amanda L. Zwilling

Dissertations, Theses, and Capstone Projects

Research conducted over the past 20 years has substantiated the serious, long-lasting impacts of child physical abuse (CPA) has on individuals, families, and society. Research has also suggested several appreciable risk factors for perpetration of CPA. Intergenerational transmission of abuse, described as the personal experience of abuse or neglect during childhood, is prominent in the literature as a predictor of subsequent perpetration of CPA. However, the majority of individuals who experience abuse in childhood do not subsequently engage in perpetration of child abuse as adults. As such, the literature has sought to investigate risk factors that mediate the relationship between …

Factors Associated With Health-Promoting Behaviors Of Adult Protective Service Workers And Professionals Who Support Vulnerable Adults, Cynthia Sterling-Fox

Dissertations, Theses, and Capstone Projects

Background: Adult protective services encompass social services provided to vulnerable adults: abused, neglected and exploited elderly and adults with significant disabilities in the United States. Adult Protective Services (APS) workers investigate allegations of abuse, neglect, and exploitation of vulnerable adults. APS workers work closely with multidisciplinary teams and professionals in various fields to assist with the investigations. APS workers and other professionals are exposed to individual and work environment stressors that result in a lower professional quality of life. There is evidence, however, that health-promoting behaviors mitigate the negative effects of stressors.

Purpose: Using the Health Promotion Theory by Nola …

Should I Stay Or Should I Go? Mexican Return Migration Across The Life Course, Mara G. Sheftel

Dissertations, Theses, and Capstone Projects

Foreign-born individuals make up a growing share of older adults in the US. Older immigrants offer an important vantage point from which to investigate integration because outcomes at older ages can be considered “final” measures providing empirical evidence for theoretical understandings of the forces impacting immigrant trajectories. However, considering the non-negligible portion of immigrants that ultimately return to their country of origin it is impossible to get the full range of immigrant outcomes without considering returnees. Further, patterns of return may differ across the life course with distinct economic, social, and health considerations at older ages. However, the impact of …

From The Voices Of Five African American Teenage Girls: Demystifying The Role Of Stress In School, Selena M. Williams-Yii

Dissertations, Theses, and Capstone Projects

This study explored how African American Teenage Girls framed and navigated their stressful experiences in educational contexts. Drawing from one-on-one interviews and focus groups, this study aimed to raise awareness about the ways African American Teenage Girls defined, interpreted, and internalized the tensions of stress in a school setting. This exploratory qualitative study was grounded in the conceptual frameworks of Black Feminist Theory (BFT), and Critical Race Theory (CRT). These theories were used to explore how systemic oppression may cause stress. By sharing their collective and individual stories, this study revealed my participants grappled with sources of stress, such as …

The Federalist Papers' Account Of Human Nature, Jeffrey P. Smith

Dissertations, Theses, and Capstone Projects

This paper is an analysis of the account of human nature found in The Federalist Papers. This interpretation assumes The Federalist is a work of political rhetoric and advocacy, but also one of genuine significance as political science and philosophy. As a book, The Federalist is a coherent whole, which offers a coherent account of human nature, despite the collective nature of its authorship, the time pressures of its publication, and the piecemeal nature of its workmanship. This understanding of human nature is the thread which runs through all its analysis and numbers. Its arguments asserting the inadequacies of …

Enhanced Platinum (Ii) Drug Delivery For Anti-Cancer Therapy, Marek T. Wlodarczyk

Dissertations, Theses, and Capstone Projects

Over the years, anti-cancer therapies have improved the overall survival rate of patients. Nevertheless, the traditional free drug therapies still suffer from side effects and systemic toxicity, resulting in low drug dosages in the clinic. This often leads to suboptimal drug concentrations reaching cancer cells, contributing to treatment failure and drug resistance. Among available anti-cancer therapies, metallodrugs are of great interest. Platinum (II)-based agents are highly potent and are used to treat many cancers, including ovarian cancer (OC). Cisplatin (cis-diaminedichloroplatinum (II)) is the first Food and Drug Administration (FDA)-approved metallodrug for treatment of solid tumors, and its mechanism …

Electro-Oxidation To Convert Dissolved Organic Nitrogen And Soluble Non-Reactive Phosphorus To More Readily Removable And Recoverable Forms, Synthia P. Mallick, Donald R. Ryan, Kaushik Venkiteshwaran, Patrick J. Mcnamara, Brooke K. Mayer

Civil and Environmental Engineering Faculty Research and Publications

Conventional wastewater treatment processes cannot effectively remove dissolved organic nitrogen (DON) and soluble non-reactive phosphorus (sNRP), which can pose regulatory compliance challenges for total nitrogen and total phosphorus discharges. Moreover, DON and sNRP are not easily recoverable for beneficial reuse as part of the waste to resource paradigm. Conversion of DON and sNRP to more readily removable dissolved inorganic nitrogen (DIN) and soluble reactive phosphorus (sRP), respectively, will help meet stringent nutrient limits and facilitate nutrient recovery. In this study, electro-oxidation (EO) was evaluated for conversion of four DON compounds to DIN and five sNRP compounds to sRP. EO was …

Artificial Night Light And Anthropogenic Noise Interact To Influence Bird Abundance Over A Continental Scale, Ashley A. Wilson, Mark A. Ditmer, Jesse R. Barber, Neil H. Carter, Eliot T. Miller, Luke P. Tyrell, Clinton D. Francis

Biology Faculty Publications and Presentations

The extent of artificial night light and anthropogenic noise (i.e., “light” and “noise”) impacts is global and has the capacity to threaten species across diverse ecosystems. Existing research involving impacts of light or noise has primarily focused on noise or light alone and single species; however, these stimuli often co-occur and little is known about how co-exposure influences wildlife and if and why species may vary in their responses. Here, we had three aims: (1) to investigate species-specific responses to light, noise, and the interaction between the two using a spatially explicit approach to model changes in abundance of 140 …

Memory-Like Differentiation Enhances Nk Cell Responses To Melanoma, Nancy D Marin, Bradley A Krasnick, Michelle Becker-Hapak, Leah Conant, Simon P Goedegebuure, Melissa M Berrien-Elliott, Keenan J Robbins, Jennifer A Foltz, Mark Foster, Pamela Wong, Celia C Cubitt, Jennifer Tran, Christopher B Wetzel, Miriam Jacobs, Alice Y Zhou, David Russler-Germain, Lynne Marsala, Timothy Schappe, Ryan C Fields, Todd A Fehniger

Open Access Publications

PURPOSE: Treatment of advanced melanoma is a clinical challenge. Natural killer (NK) cells are a promising cellular therapy for T cell-refractory cancers, but are frequently deficient or dysfunctional in patients with melanoma. Thus, new strategies are needed to enhance NK-cell antitumor responses. Cytokine-induced memory-like (ML) differentiation overcomes many barriers in the NK-cell therapeutics field, resulting in potent cytotoxicity and enhanced cytokine production against blood cancer targets. However, the preclinical activity of ML NK against solid tumors remains largely undefined.

EXPERIMENTAL DESIGN: Phenotypic and functional alterations of blood and advanced melanoma infiltrating NK cells were evaluated using mass cytometry. ML NK …

Vol. 50, No. 1: Full Issue, Denver Journal Of International Law & Policy

Denver Journal of International Law & Policy

No abstract provided.

A Grounded Theory Analysis Of Black African International Students’ Racial Identity Development, Maame Coleman

Dissertations

This study was designed to explore how Black African international students develop an understanding of their racial identity within the U.S. context. Although there has been considerable previous theoretical and empirical work examining the process of racial identity development (e.g. Cross, 1971; Sellers et al.1998), which has provided foundation for how we continue to understand how U.S. racial minorities develop their racial identities. However, there is a paucity of research on the racial identity development process of non-U.S. born Black people (Hocoy, 1999; Asante, 2012). Even less is known about the role that intersectionality of other identities plays in the …

A Behavior Genetic Study Of Activity Levels And Internalizing Problems Across Childhood, Matthew Jamnik

Dissertations

This study used a twin and triplet sample to investigate the influence of preschoolers’ physical activity levels and internalizing problems on subsequent health outcomes (body-mass index, internalizing behavior problems, household health behaviors) in middle childhood. The potential influence of stressors salient in childhood (household chaos, socioeconomic status, stressful life events) on the hypothesized relationship between physical activity and internalizing on health was also explored. A specific focus was placed on examining the underlying genetic and environmental influences of children’s physical activity levels, as assessed by both temperamental (parent-reported) activity levels and observed (in-lab) motor behavior, using a behavioral genetic approach. …