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Ethanol Extract Of Marigold Flower (Tagetes Erecta L.) Decreases The Total Cholesterol, Low Density Lypoprotein (Ldl), Malondialdehyde (Mda), And Apoliprotein B (Apob) On Hyperlipidemia Rat Models, I Nyoman Bagus Aji Kresnapati, Siti Khaerunnisa, Indri Safitri

Folia Medica Indonesiana

This study aimed to determine the effect of ethanol extract of gemitir flower (Tagetes erecta L.) on total cholesterol levels, Low-Density Lipoprotein C (LDL), Malondialdehyde (MDA), Apolipoprotein B (ApoB). Forty-eight Rattus norvegicus were randomly divided into 6 groups, groups were given standard feed (K-) and 5 groups of hyperlipidemia models (K +, P1, P2, P3, P4) were given High Fat Diet (HFD) for 35 days. On the 36th day, the total cholesterol levels were checked through the tail of Rattus norvegicus, and from day 37 to day 50 were given a normal diet (K-), HFD (K +), simvastatin 10 mg/kgBW …

Effect Of High Fat Diet On Body Weight, Visceral Fat Weight, And Pparg Expressions On Visceral Fat In Mice, Cantika Putri Melyana, Purwo Sri Rejeki, Sony Wibisono Mudjanarko, Lilik Herawati, Mohammad Anam Al-Arif

Folia Medica Indonesiana

Obesity becomes a global epidemic nowadays. The high-fat diet is used as an alternative therapy for obesity. The optimal composition of a high-fat diet to reduce body weight is still unknown. This study aimed to determine which components of a high-fat diet can decrease body weight, visceral fat, and PPARG expression of visceral fat. This study was conducted at the Faculty of Veterinary Medicine, Universitas Airlangga, for three months by using a randomized post-test only control group design. Fifty male mice, 2-3 months old, 18-30 grams were adapted for one week given standard diet AIN93-M, then mice were divided into …

The Effect Of The Cucumber Consumption To The Level Of Sodium Potassium In Mus Muscullus's Urine Production, Vincensa Elicia, Bambang Wasito Tjipto, Bernadette Dian Novita

Folia Medica Indonesiana

Cucumber (Cucumis sativus L.). was known for lowering blood pressure agents. Some researches show that Cucumber had a similar mechanism with a loop diuretic (Furosemide), exceeding sodium and potassium excretion. However, a part of Cucumber that gives a better effect on managing water and sodium balance remains unknown. This study was to explain the differences potential diuretic among parts of Cucumber (Cucumis sativus L.). This study was using a post-test only control group designed in animals. There were 44 male Mus musculus tested in this study. All of the animal testings was divided into 9 different treatment groups and 2 …

Bladder Chondrosarcoma In A Male: A Rare Case Report, Muhammad Husni Tamrin, Wahjoe Djatisoesanto

Folia Medica Indonesiana

Chondrosarcoma is a rare variant of bladder tumor and one of the rare types of soft tissue sarcoma. This case happened on a 36-year-old male who complained of lumps in his lower abdomen, accompanied by difficulties in passing urine and painful urination, without hematuria. We performed TURBT and histopathological examination showed low-grade chondrosarcoma. The patient was diagnosed with low-grade bladder chondrosarcoma. The patient was treated for chemotherapy and radiotherapy. However, after undergoing one cycle of chemotherapy, the patient refused to continue the therapy.

The Nature Of Cofilin’S Severing Mechanism, Ethan Lester

The Yale Undergraduate Research Journal

Cofilin plays an essential role in regulating actin filament propagation through the cytoplasmic medium. Over the years, various studies have been conducted in an attempt to better understand the complex mechanism by which cofilin promotes filament severing and de-polymerization. Here, we have compiled information obtained from these studies in order to craft a more complete and succinct description of cofilin functionality. In particular, we review the precise structural and mechanical changes associated with cofilin-binding, and the subtle ways in which some of these structural changes may be interconnected.

Metabolic Control Of Stem Cell Ageing And Longevity Through Caloric Restriction, Valerie Navarrete

The Yale Undergraduate Research Journal

While prior studies have identified recurring genetic patterns, gaps of knowledge still remain in existing aging mechanisms; where they originate, and how they offer insight to environmental disruptions that dictate health over time. Given the inescapability of age-related deterioration and pathology, stitching together current literature may help demystify the biological process common to all living mammals. The physiological disruption of aged tissue reflects a cellular dependence on environmental cues and historical wear. Retaining the capacity to differentiate into any cell type, a stem cell best parallels a call-and-response relationship between organ and cell. As the longest living proliferative cell in …

Examining The Viability Of Computational Psychiatry: Approaches Into The Future, Mitchell Ostrow

The Yale Undergraduate Research Journal

As modern medicine becomes increasingly personalized, psychiatry lags behind, using poorly-understood drugs and therapies to treat mental disorders. With the advent of methods that capture large quantities of data, such as genome-wide analyses or fMRI, machine learning (ML) approaches have become prominent in neuroscience. This is promising for studying the brain’s function, but perhaps more importantly, these techniques can potentially predict the onset of disorder and treatment response. Experimental approaches that use naive machine learning algorithms have dominated research in computational psychiatry over the past decade. In a critical review and analysis, I argue that biologically realistic approaches will be …

A Dispersive Force Model Of Caribbean Island Biogeography, Anthony Sarkiss

The Yale Undergraduate Research Journal

Framework-based models serve as an important tool to describe, predict and manage ecological systems. In this paper I construct one such model, a dispersive force model based on MacArthur and Wilson’s (1963) theory of island biogeography, in order to assess island species richness with varying climatic patterns. Specifically, I use island–mainland distance (d), insular area (A), a climatic dispersal parameter (f), and a climatic disturbance parameter (h) to calculate the insular species richness ratio at equilibrium. To test this model through hurricane impact on marine islands, it was executed with data from islands of the Dutch Caribbean. Future climatic conditions …

Progressive Neoliberalism Isn't The Solution. We Need A Radical, Counter-Hegemonic And Anti-Capitalist Alliance. A Conversation With Nancy Fraser, Nancy Fraser, Lara Monticelli

Emancipations: A Journal of Critical Social Analysis

During the annual meeting of the research network “Alternatives to Capitalism” held at the New School for Social Research in New York City in 2019, Professor Nancy Fraser engaged in a vibrant discussion about one of her latest books, “Capitalism. A Conversation in Critical Theory”, co-authored with Rahel Jaeggi (Polity Press, 2018). Here is a shortened and edited extract of the conversation.

Seasonal Growth Curves Of Perennial Ryegrass In Mexico, M. E. Z. Velasco, Alfonso Hernández-Garay, J. P. Pérez, V. A. González-Hernández

IGC Proceedings (1977-2023)

An experiment was established at Colegio de Postgraduados Research Station, Texcoco, México to evaluate the seasonal pattern of growth curve of perennial ryegrass (Lolium perenne) swards. Growth rate increases rapidly from a low level immediately after defoliation, and eventually reaches an equilibrium level as the amount of green leaf in the sward stabilize. The time required to reach this state varied according to the season of year, with the four seasons ranked in the order: spring (4 weeks) < summer (5 weeks) < autumn and winter (6 weeks). Once swards reached equilibrium, growth rates started to decline as a consequence of an increase in dead material and pseudostem. These increases were highest in spring and lowest in winter. The results of this study suggest that sward management to maximise herbage production and utilisation in ryegrass swards must be done once the highest green leaf mass is reached. In this trial, it was reached at 5, 6, 6 and 4 weeks in summer, autumn, winter and spring, respectively.

The Effects Of Planting Density On The Dry Matter Yield And The Overwintering Ability Of The Dwarf And Normal Napiergrasses In Two Years After Planting, Yasuyuki Ishii, M. M. Mukhtar, Sayan Tudsri

IGC Proceedings (1977-2023)

The objective of this study is to determine the optimum planting density in napiergrass (Pennisetum purpureum Schumach) among two dwarf varieties introduced from Thailand and two normal ones under three levels of density. Dwarf varieties showed lower plant height and mean tiller weight, and higher leaf area index (LAI) and leaf blade percentage. Crop growth rate was positively correlated with LAI, and net assimilation rate and canopy extinction coefficient (K) were negatively correlated with LAI in the second year, including all dwarf and normal varieties, while K tended to be lower in the dwarf varieties. With the increase in …

Light Interception And Dry Matter Yield In Grass/Legume Mixtures, H. A. Jönsson

IGC Proceedings (1977-2023)

The influence of grass variety on light interception and dry matter yield in a grass/clover mixture was studied. Two varieties of timothy (Phleum pratense L.) and five varieties of ryegrass (Lolium spp) as components in a mixture were compared during the spring period up to the first cut of the third harvest year. By replacing the timothy variety in the mixture both light interception and dry matter yield were significantly affected. The leaf orientation was thought to be a contributing factor with erect leaves intercepting less light. There were no significant differences neither in light interception nor …

Photosynthetic Light Response Of Tanzania Grass Under Four Levels Of Leaf Temperature, A. C. L. De Mello, P. M. Santos, Carlos G. S. Pedreira, M. Corsi, C. T. Dos S. Dias

IGC Proceedings (1977-2023)

The purpose of this paper is to establish photosynthetic light response curves for Tanzania grass (Panicum maximum Jacq.) under four leaf temperature levels. Photosynthetic rate was measured as a response to levels of photosynthetic photon flux density (PPFD) on the youngest fully expanded leaves of 12 representative tillers with an infra red gas analyzer. The effect of PPFD was tested for each leaf temperature level in a randomized complete block design. Photosynthetic light response curves were adjusted for each leaf temperature using a non-linear hyperbolic model. The maximum photosynthetic response was 25,59; 31,43; 34,57 and 27,53 µmol CO_{2 …}

Nonstructural Carbohydrate Reserves Of Temperate Perennial Grasses In Autumn Early Growth, Y. Tamura, K. Matoba, A. Fushimi, M. Moriyama

IGC Proceedings (1977-2023)

The objective of this study was to determine levels of nonstructural carbohydrate reserves of four temperate perennial grasses: Orchardgrass (Dactylis glomerata L.), Timothy (Phleum pratense L.), Perennial ryegrass (Lolium perenne L.), and Reed canarygrass (Phalaris arundinacea L.) in their early growth stages during the cool autumn temperatures in northern Japan. At the time of sampling, all grasses were in their vegetative stage, and Reed canarygrass was not forming rhizomes. Fructosan concentration in reed canarygrass roots (8.04%) was 22 times that of the leaf blade (0.36%) and twice that of the stem (3.40%); the concentration in reed …

Using A Self-Determination Theory Approach To Understand Student Perceptions Of Inquiry-Based Learning, Fangfang Zhao, Gillian Roehrig, Lorelei E. Patrick, Chantal Levesque-Bristol, Sehoya Cotner

Biological Sciences Faculty Publications

Inquiry-based laboratory activities, as a part of science curricula, have been advocated to increase students’ learning outcomes and improve students’ learning experiences, but students sometimes struggle with open-inquiry activities. This study aims to investigate students’ perceptions of inquiry-based learning in a set of laboratory activities, specifically from a psychological (i.e., Self-Determination Theory) perspective. Students’ ratings of the level of inquiry in these activities indicate that students’ perceptions of inquiry align with the instructor-intended amount of inquiry in each exercise. Students’ written responses, explaining their ratings, indicate that students’ perceptions of the amount of inquiry in a given lab exercise relate …

Fusion And Beyond: Satellite Cell Contributions To Loading-Induced Skeletal Muscle Adaptation, Kevin A. Murach, Christopher S. Fry, Esther E. Dupont-Versteegden, John J. Mccarthy, Charlotte A. Peterson

Center for Muscle Biology Faculty Publications

Satellite cells support adult skeletal muscle fiber adaptations to loading in numerous ways. The fusion of satellite cells, driven by cell-autonomous and/or extrinsic factors, contributes new myonuclei to muscle fibers, associates with load-induced hypertrophy, and may support focal membrane damage repair and long-term myonuclear transcriptional output. Recent studies have also revealed that satellite cells communicate within their niche to mediate muscle remodeling in response to resistance exercise, regulating the activity of numerous cell types through various mechanisms such as secretory signaling and cell–cell contact. Muscular adaptation to resistance and endurance activity can be initiated and sustained for a period of …

Mss0330. Alfred Woollacott Family Papers Finding Aid

Special Collections Finding Aids

The collection contains the letters from Alfred Woollacott (1892- 1986) while serving in World War I, and letters from his sons Alfred (1922-1967) and Paul (b. ca. 1926) during their service in World War II. Also contains photographs and ephemera.

Intermittent Bolus Compared With Continuous Feeding Enhances Insulin And Amino Acid Signaling To Translation Initiation In Skeletal Muscle Of Neonatal Pigs, Agus Suryawan, Samer W El-Kadi, Hanh V Nguyen, Marta L Fiorotto, Teresa A Davis

Children’s Nutrition Research Center Staff Publications

Background: Nutrition administered as intermittent bolus feeds rather than continuously promotes greater protein synthesis rates in skeletal muscle and enhances lean growth in a neonatal piglet model. The molecular mechanisms responsible remain unclear.

Objectives: We aimed to identify the insulin- and/or amino acid-signaling components involved in the enhanced stimulation of skeletal muscle by intermittent bolus compared to continuous feeding in neonatal pigs born at term.

Methods: Term piglets (2-3 days old) were fed equal amounts of sow milk replacer [12.8 g protein and 155 kcal/(kg body weight · d)] by orogastric tube as intermittent bolus meals every 4 hours (INT) …

A Computational Study Of Genotype-Phenotype Mutation Patterns, Kamaludin Dingle, Omar Tawfik, Ahmed Aldabagh

Undergraduate Research Symposium

Understanding properties of genotype-phenotype maps is important for understanding biology and evolution. In this project we make a computational study of the statistical effects of genetic mutations, in particular computing the probabilities of each phenotype transitioning to any other phenotype. We also investigate the importance of the local phenotypic environment of a single genotype, and its role in determining mutation transition probabilities. We use HP protein folding, RNA structure, and a simplified GRN matrix model to study these questions.

Phenotype Bias Determines How Natural Rna Structures Occupy The Morphospace Of All Possible Shapes, Fatme Ghaddar, Dr Kamaludin Dingle, Dr Petr Sulc, Prof Ard A. Louis

Undergraduate Research Symposium

The relative prominence of developmental bias versus natural selection is a long standing controversy in evolutionary biology. Here we demonstrate quantitatively that developmental bias is the primary explanation for the occupation of the morphospace of RNA secondary structure (SS) shapes. By using the RNAshapes method to define coarse-grained SS classes, we can measure the frequencies that non-coding RNA SS shapes appear in nature. Our main findings are firstly that only the most frequent structures appear in nature; the vast majority of possible structures in the morphospace have not yet been explored. Secondly, and perhaps more surprisingly, these frequencies are accurately …

Principle Components Analysis To Characterize Stress, Performance, And Injury In Female Collegiate Soccer Players, Lindsey S. Cook, Steven Leigh, Suzanne Konz

ISBS Proceedings Archive

Stress created by training is needed to elicit physiological adaptations to increase performance, however, a stress threshold exists. We assessed 19 female collegiate soccer players during an eleven week preparatory phase and measured stress, performance, and injury variables. We used a principal component analysis to determine relationships among stress, performance, and injury. We found a weak, negative relationship between practice stress and anaerobic stress (r = -0.107, p = 0.05), a positive relationship between anaerobic stress and movement risk of injury (r = 0.459, p

Is Actn3 R577x Genotype Associated With Weight-Bearing Index In Male College Students?, Akihiro Azuma, Toshiyuki Kawamura, Kazuhiro Matsui

ISBS Proceedings Archive

The purpose of this study was to determine the association between weight-bearing index (WBI) and ACTN3 genotype in male college students. Subjects were healthy male college students aged 18 to 21 years old. The maximal static forces of knee extension (leg strength) of the subjects were measured, and WBI was calculated by dividing the leg strength by the subjects’ body weight. Genomic DNA was extracted from each subject using hair strands, and its base sequence determined genotypes in RR, RX, and XX. Welch-type ANOVA revealed that WBI in the XX type was greater than in the RR and RX types …

Cutting Sex-Performance Differences Down To Size: Are Females Closer To Males In Shorter Sprint Races?, Emily Mcclelland, Peter Weyand

ISBS Proceedings Archive

The body size and composition differences between men and women are set by genetic factors with relatively constant offsets, particularly in homogeneous athletic populations. However, performance differences between the sexes appear to be more variable, potentially due to the mechanical demands of different events. Here, we set out to analyse the sex performance differences across sprint running events that differ in mechanical demands due to race length. Based on the scaling of tissue areas in relation to body mass, shorter, smaller athletes should be more forceful per kg body mass than larger ones. Greater force per kg body mass capabilities …

Coordniation Of Center Of Mass Velocity And Upper Extremity Kinematics During Basketball Shots From Two Distances, Casey Wiens, Jill Mcnitt-Gray

ISBS Proceedings Archive

The purpose of this study was to analyze the coordination patterns for individual players when shooting from different distances. Seven experienced basketball players attempted at least 10 shots from 4.19 m and 6.02 m from the hoop. The coordination between the player’s center of mass vertical velocity, upper arm angular velocity, and forearm angular velocity were characterized using phase-plane analysis. Within player, coordination of center of mass vertical velocity and arm kinematics were found to be unique to each individual and comparable between shot distances, particularly during the shot preparation phase. Deviations in coordination patterns between shot distances were attributed …

Changes In 800 Meter Personal Records For Competitive Female Runners From High School To College, Harper E. Stewart, Nathan Phillips, Jill L. Mcnittgray

ISBS Proceedings Archive

TTo advance understanding of improvements in running performance, changes in personal records (PR) from high school to college were compared. It was hypothesized that females competing in the 800m in college would improve PR times from high school to college, improvements would be different between athletic conferences, and modern statistical methods could differentiate trends in the relationship between high school and college PR. Data from female athletes competing in the 800m from three different athletic conferences (n=73) were gathered from published race results and 79.4% improved by at least 1s with no significant differences between conferences. A positive relationship exists …

Predicting 3d Ground Reaction Force From 2d Video Via Neural Networks In Sidestepping Tasks, Corey Morris, Marion Mundt, Molly Goldacre, Jason Weber, Ajmal Mian, Jacqueline Alderson

ISBS Proceedings Archive

Sports science practitioners often measure ground reaction forces (GRFs) to assess performance, rehabilitation and injury risk. However, recording of GRFs during dynamic tasks has historically been limited to lab settings. This work aims to use neural networks (NN) to predict three-dimensional (3D) GRF via pose estimation keypoints as inputs, determined from 2D video data. Two different NN were trained on a dataset containing 1474 samples from 14 participants and their prediction accuracy compared with ground truth force data. Results for both NN showed correlation coefficients ranging from 0.936 to 0.954 and normalised root mean square errors from 11.05% to 13.11% …

Linearity Of The Ratio Of Forces-Velocity Relationship Is Not Related To Initial Acceleration Performance In Sprinting, Daniel King, Louise Burnie, Ryu Nagahara, Neil Bezodis

ISBS Proceedings Archive

The relationship between the linearity of the ratio of forces (RF)-horizontal velocity (v_H) profile and initial acceleration (IA) performance was investigated in trained sprinters. Ground reaction force data from the IA phase of a maximal sprint from a block start were analysed. The coefficient of determination of the linear trendline fitted to four step-averaged values of RF and v_H provided a measure of linearity. Semi-partial correlations (sr) accounting for block phase performance revealed a weak negative relationship between linearity of the RF-v_H profile and performance over the first four steps (sr = -0.11), while mean RF …

Support Vector Machines Can Classify Runner’S Ability Using Wearable Sensor Data From A Variety Of Anatomical Locations, Josh A. Carter Mr, Adrian R Rivadulla, Ezio Preatoni

ISBS Proceedings Archive

We developed and tested an algorithm to automatically classify twenty runners as novice or experienced based on their technique. Linear accelerations and angular velocities collected from six common wearable sensor locations were used to train support vector machine classifiers. The model using input data from all six sensors achieved a classification accuracy of 98.5% (10 km/h running). The classification performance of models based on single sensor data showed a 56.3-94.5% accuracy range, with sensors from the upper body giving the best results. Comparisons of kinematic variables between the two populations confirmed significant differences in upper body biomechanics throughout the stride, …

The Three-Dimentional Pelvic Motion In The Acceleration And Maximum Phases, Kazuki Ota, Takuya Yoshida, Hirohiko Maemura, Satoru Tanigawa

ISBS Proceedings Archive

The purpose of this study was to investigate the mechanism of pelvic motion in the acceleration and maximum velocity phases. Eleven male sprinters performed 30 m and 60 m sprints at maximal effort and captured sprint movement at 15 m and 50 m. The contact time was significantly longer, and the angular displacement of pelvic elevation on the frontal plane was significantly greater in the acceleration phase than in the maximum velocity phase. Additionally, the angular displacement of pelvic elevation on the frontal plane showed a significantly positive correlation with the contact time and the stance length in the acceleration …

The Rapid Stretch Stimulus Does Not Enhance Muscle Strength In Active Individuals Following A 4-Week Proprioceptive Neuromuscular Strengthening Protocol., Aditi P. Vyas, Sarah Breen

ISBS Proceedings Archive

Proprioceptive neuromuscular facilitation (PNF) a technique widely used as a training modality among physically active individuals. PNF in the upper limb is combined with the rapid stretch stimulus at the beginning of every repetition of resistive diagonal PNF. The stretch stimulus is applied at the palm of the hand & fingers in the opposite direction to activate receptors. The aim of the study was to evaluate the effects of stretch stimulus with PNF exercises over 4-weeks for improvements in muscle strength. Eight participants were recruited & randomly divided into the CG, n=4 with no stretch stimulus & EG, n=4 with …