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September 17, 2021 Board Of Trustees Meeting Report, Board Of Trustees

Board of Trustees

No abstract provided.

Minutes, September 2021, University Of Dayton. College Of Arts And Sciences

Documents of the College of Arts and Sciences Academic Affairs Committee

Minutes from College of Arts and Sciences Academic Affairs Committee

Variants Of Facial Shape Genes In Patients With Class Ii Or Class I Malocclusion, Mahsa Mortazavi, Marie M. Tolarová Md, Phd, Drsc, Mirek Tolar

Orthodontics and Endodontics Theses

Background and purpose: In recent years, questions regarding the genetic and environmental factors affecting variation in human craniofacial morphology have received increasing attention. Medical and clinical genetic research using family studies has proven foundational for our understanding of which genes affect craniofacial variation. On the other hand, cephalometricbased studies showed a relationship between the cranial base and midface characteristics among individuals with different skeletal pattern of malocclusion. The purpose of our pilot study was to analyze specific variants of facial genes that were suggested to be associated with cranial base width and depth in Class II and Class I malocclusions. …

Oral Microbiome And Gingival Gene Expression Of Inflammatory Biomolecules With Aging And Periodontitis, Jeffrey L. Ebersole, Radhakrishnan Nagarajan, Sreenatha S. Kirakodu, Octavio A. Gonzalez

Center for Oral Health Research Faculty Publications

Although data describe the presence and increase of inflammatory mediators in the local environment in periodontitis vs. health in humans, details regarding how these responses evolve in the transition from health to disease, changes during disease progression, and features of a resolved lesion remain unknown. This study used a nonhuman primate model of ligature-induced periodontitis in young, adolescent, adult, and aged animals to document features of inflammatory response affected by age. Rhesus monkeys had ligatures tied and provided gingival tissue biopsy specimens at baseline, 0.5, 1, and 3 months of disease and at 5 months of the study, which was …

Science Café | Plants In Space Athens We Have A Problem, Oct. 14, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Associations Between Varied Susceptibilities To Pfatp4 Inhibitors And Genotypes In Ugandan Plasmodium Falciparum Isolates., Oriana Kreutzfeld, Stephanie A. Rasmussen, Aarti A. Ramanathan, Patrick K. Tumwebaze, Oswald Byaruhanga, Thomas Katairo, Victor Asua, Martin Okitwi, Stephen Orena, Jennifer Legac, Melissa D. Conrad, Samuel L. Nsobya, Ozkan Aydemir, Jeffrey Bailey, Maelle Duffey, Brett R. Bayles, Akhil B. Vaidya, Roland A. Cooper, Philip J. Rosenthal

Natural Sciences and Mathematics | Faculty Scholarship

Among novel compounds under recent investigation as potential new antimalarial drugs are three independently developed inhibitors of the Plasmodium falciparum P-type ATPase (PfATP4): KAE609 (cipargamin), PA92, and SJ733. We assessed ex vivo susceptibilities to these compounds of 374 fresh P. falciparum isolates collected in Tororo and Busia districts, Uganda, from 2016 to 2019. Median IC50s were 65 nM for SJ733, 9.1 nM for PA92, and 0.5 nM for KAE609. Sequencing of pfatp4 for 218 of these isolates demonstrated many nonsynonymous single nucleotide polymorphisms; the most frequent mutations were G1128R (69% of isolates mixed or mutant), Q1081K/R (68%), G223S (25%), N1045K …

Rural Students' College Choice And The Impact Of Dual Enrollment Programs And College Cost, Elise J. Cain

New York Journal of Student Affairs

This article explores the college-choice processes of two college students who graduated high school from rural areas in New York State. Hossler and Gallagher’s (1987) three-stage model of the college-choice process was used as the theoretical framework for this study. To gain in-depth knowledge about students’ predisposition, search, and choice stages, narrative inquiry was employed. This article specifically highlights how dual enrollment courses played key roles within the college-choice processes of these students. These findings suggest that there is a need for additional education about college costs and dual enrollment programs for rural students and their families.

Trace Fossils, Algae, Invertebrate Remains And New U-Pb Detrital Zircon Geochronology From The Lower Cambrian Torneträsk Formation, Northern Sweden, Stephen Mcloughlin, Vivi Vajda, Timothy P. Topper, James L. Crowley, Fan Liu, Ove Johansson, Christian B. Skovsted

Geosciences Faculty Publications and Presentations

Nineteen ichnotaxa, together with algal and invertebrate remains, and various pseudo-traces and sedimentary structures are described from the Torneträsk Formation exposed near Lake Torneträsk, Lapland, Sweden, representing a marked increase in the diversity of biotic traces recorded from this unit. The “lower siltstone” interval of the Torneträsk Formation contains mostly simple pascichnia, fodinichnia and domichnia burrows and trails of low-energy shoreface to intertidal settings. The assemblage has very few forms characteristic of high-energy, soft-sediment, foreshore or upper shoreface environments (representative of the Skolithos ichnofacies).

Uranium-lead (U-Pb) LA-ICPMS analysis of zircon from a thin claystone layer within the “lower siltstone” interval …

Where Epigenetics Meets Food Intake: Their Interaction In The Development/Severity Of Gout And Therapeutic Perspectives, Philippe T. Georgel, Philippe Georgel

Biological Sciences Faculty Research

Gout is the most frequent form of inflammatory arthritis in the world. Its prevalence is particularly elevated in specific geographical areas such as in the Oceania/Pacific region and is rising in the US, Europe, and Asia. Gout is a severe and painful disease, in which co-morbidities are responsible for a significant reduction in life expectancy. However, gout patients remain ostracized because the disease is still considered “self-inflicted”, as a result of unhealthy lifestyle and excessive food and alcohol intake. While the etiology of gout flares is clearly associated with the presence of monosodium urate (MSU) crystal deposits, several major questions …

A Structural Study Of The Cytoplasmic Chaperone Effect Of 14-3-3 Proteins On Ataxin-1, Seppe Leysen, Rebecca Jane Burnley, Elizabeth Rodriguez, Lech-Gustav Milroy, Lorenzo Soini, Carolyn J. Adamski, Larissa Nitschke, Rachel Davis, Tomas Obsil, Lucas Brunsveld, Tom Crabbe, Huda Yahya Zoghbi, Christian Ottmann, Jeremy Martin Davis

Faculty Publications

Expansion of the polyglutamine tract in the N terminus of Ataxin-1 is the main cause of the neurodegenerative disease, spinocerebellar ataxia type 1 (SCA1). However, the C-terminal part of the protein - including its AXH domain and a phosphorylation on residue serine 776 - also plays a crucial role in disease development. This phosphorylation event is known to be crucial for the interaction of Ataxin-1 with the 14-3-3 adaptor proteins and has been shown to indirectly contribute to Ataxin-1 stability. Here we show that 14-3-3 also has a direct anti-aggregation or "chaperone" effect on Ataxin-1. Furthermore, we provide structural and …

September 17, 2021 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Daily Eastern News: September 17, 2021, Eastern Illinois University

September

No abstract provided.

2021 September 17 - Board Of Trustees Finance And Administration Committee Agenda And Minutes, Board Of Trustees, East Tennessee State University

Board of Trustees Agendas and Minutes

No abstract provided.

Chancellor’S Cabinet Updates 2021-09, Karen Carey

Chancellor's Cabinet Updates

No abstract provided.

Board Of Trustees Meeting Minutes, September 17,2021

Board of Trustees Minutes

Minutes from the Wright State University Board of Trustees Meeting held on September 17, 2021

Wmu Board Of Trustees Formal Sessionseptember 17, 2021, Wmu Board Of Trustees

WMU Board of Trustees Meetings

Acceptance of the Agenda – Chen-Zhang

Approval of the Minutes (June 24, 2021 Meeting) – Chen-Zhang

Remarks by the Chair – Chen-Zhang

Remarks by the President – Montgomery

Updates by the Faculty Senate President – Kritzman

Updates by the Western Student Association President – Morris

Updates by the Graduate Student Association President – Hiremath

Navigating Excellence in Aviation – Powell

Public Comments Regarding Action Items – Schuemann

Action Items – Chen-Zhang

1. Labor Agreements

• International Alliance of Theatrical Stage Employees Labor Agreement – Van Der Kley
• Professional Instructors Organization Labor Agreement – Bott
• Western Michigan University American Association of University Professors …

Phenotypic/Genotypic Profile Of Oxa-10-Like-Harboring, Carbapenem-Resistant Pseudomonas Aeruginosa: Using Validated Pharmacokinetic/Pharmacodynamic In Vivo Models To Further Evaluate Enzyme Functionality And Clinical Implications, Fred C. Tenover, Christian M. Gill, Adrian Brink, Chun Yat Chu, Jennifer Coetzee, George Dimopoulos, Clinton Moodley, Christoffel Johannes Opperman, Spyros Pournaras, Isabella A. Tickler, Hafsah Deepa Tootla, Sophia Vourli, David P. Nicolau

Biology Faculty Publications

In vitro MICs and in vivo pharmacodynamics of ceftazidime and cefepime human-simulated regimens (HSR) against modified carbapenem inactivation method (mCIM)-positive Pseudomonas aeruginosa isolates harboring different OXA-10-like subtypes were described. The murine thigh model assessed ceftazidime (2 g every 8 h [q8h] HSR) and cefepime (2 g and 1 g q8h HSR). Phenotypes were similar despite possessing OXA-10-like subtypes with differing spectra. Ceftazidime produced ≥1-log10 killing in all isolates. Cefepime activity was dose dependent and MIC driven. This approach may be useful in assessing the implications of β-lactamase variants.

Nsg-Pro Mouse Model For Uncovering Resistance Mechanisms And Unique Vulnerabilities In Human Luminal Breast Cancers, Yunguang Sun, Ning Yang, Fransiscus E Utama, Sameer S Udhane, Junling Zhang, Amy R Peck, Alicia Yanac, Katherine Duffey, John F Langenheim, Vindhya Udhane, Guanjun Xia, Jess F Peterson, Julie M Jorns, Marja T Nevalainen, Romain Rouet, Peter Schofield, Daniel Christ, Christopher J Ormandy, Anne Rosenberg, I Chervoneva, Shirng-Wern Tsaih, Michael J Flister, Serge Y Fuchs, Kay-Uwe Wagner, Hallgeir Rui

Department of Surgery Faculty Papers

Most breast cancer deaths are caused by estrogen receptor-α-positive (ER+) disease. Preclinical progress is hampered by a shortage of therapy-naïve ER+ tumor models that recapitulate metastatic progression and clinically relevant therapy resistance. Human prolactin (hPRL) is a risk factor for primary and metastatic ER+ breast cancer. Because mouse prolactin fails to activate hPRL receptors, we developed a prolactin-humanized Nod-SCID-IL2Rγ (NSG) mouse (NSG-Pro) with physiological hPRL levels. Here, we show that NSG-Pro mice facilitate establishment of therapy-naïve, estrogen-dependent PDX tumors that progress to lethal metastatic disease. Preclinical trials provide first-in-mouse efficacy of pharmacological hPRL suppression on residual ER+ human breast cancer …

Interrupted Course Of Antitumor Necrosis Factor Alpha Therapy Versus Combined Nonsteroidal Anti-Inflammatory Drug Therapy And Physiotherapy In Patients With Ankylosing Spondylitis: A Comparative Study, Sherry K. Abdelrahman, Taghreed F. M. Mostafa

Journal of Medicine in Scientific Research

Aim The aim was to evaluate the efficacy of interrupted course of antitumor necrosis factor alpha (TNF-α) blocking agents (etanercept and adalimumab) as 3-month-on-and-3-month-off regimen versus combined regimen of physiotherapy and NSAIDs in patients with ankylosing spondylitis (AS) within a 2-year period. Patients and methods A total of 60 patients who fulfilled the Modified New York Criteria for AS were enrolled in the current study and divided into two equal groups: one received interrupted course of anti-TNFα agents and one received NSAIDs plus physiotherapy. Both groups were subjected to follow-ups at 6, 12, 18, and 24 months. To assess the …

Preterm Births In South-West England Before And During The Covid-19 Pandemic: An Audit Of Retrospective Data, Kate Maslin, Roisin Mckeon-Carter, Joanne Hosking, Lauren Stockley, Clara Southby, Jill Shawe, Jos M. Latour

School of Nursing and Midwifery

No abstract provided.

Boko-Haram Insurgency: Correlating Information Needs Of Members Of Vigilante In Adamawa State, North-East Nigeria., Muhammad Murtala Ibrahim, Idris A. Dano

Library Philosophy and Practice (e-journal)

The study correlated the Information needs of Members of Vigilante to other Information activities in Adamawa state, North-eastern Nigeria. Quantitative research methodology and Cross-sectional survey design was applied for the study. The population comprised of One Thousand Four Hundred Members (1400) drawn from Nineteen (19) local governments areas in the state. Krejcie and Morgan Table (1970) was used to draw (302) members as sample of the population, while Walpole’s (1982) formula for proportions was used in arriving at a sample for each stratum (i.e. each local government area). In collecting data, a total of Three Hundred and Two (302) copies …

Development Of A Recombinant Vaccine Against Human Onchocerciasis., David Abraham, John Graham-Brown, Darrick Carter, Sean A. Gray, Jessica A. Hess, Benjamin L. Makepeace, Sara Lustigman

Department of Microbiology and Immunology Faculty Papers

Introduction: Human onchocerciasis caused by the filarial nematode parasite Onchocerca volvulus remains a major cause of debilitating disease infecting millions primarily in Sub-Saharan Africa. The development of a prophylactic vaccine, along with mass drug administration, would facilitate meeting the goal of onchocerciasis elimination by 2030.

Areas covered: Models used to study immunity to Onchocerca include natural infection of cattle with Onchocerca ochengi and O. volvulus infective third-stage larvae implanted within diffusion chambers in mice. A vaccine, comprised of two adjuvanted recombinant antigens, induced protective immunity in genetically diverse mice suggesting that it will function similarly in diverse human populations. These …

Use Of Pressure-Measuring Insoles To Characterize Gait Parameters In Simulated Reduced-Gravity Conditions, Christian Ison, Connor Neilsen, Jessica Deberardinis, Mohamed B. Trabia, Janet S. Dufek

Mechanical Engineering Faculty Research

Prior researchers have observed the effect of simulated reduced-gravity exercise. However, the extent to which lower-body positive-pressure treadmill (LBPPT) walking alters kinematic gait characteristics is not well understood. The purpose of the study was to investigate the effect of LBPPT walking on selected gait parameters in simulated reduced-gravity conditions. Twenty-nine college-aged volunteers participated in this cross-sectional study. Participants wore pressure-measuring insoles (Medilogic GmBH, Schönefeld, Germany) and completed three 3.5-min walking trials on the LBPPT (AlterG, Inc., Fremont, CA, USA) at 100% (normal gravity) as well as reduced-gravity conditions of 40% and 20% body weight (BW). The resulting insole data were …

Music Listening: An Evidence-Based Approach To Help Manage Postoperative Pain, Tammie Ferguson

Dissertations

The current standard of practice to manage postoperative pain includes the use of opioids. The purpose of this evidence-based project was to evaluate the effectiveness of music listening as an adjuvant to traditional pain management strategies to relieve postoperative pain and to assess the dosage of opioids used to help manage postoperative pain. Kolcaba's Comfort Theory was used to guide this evidence-based project.

Autologous And Allogeneic Hematopoietic Cell Transplantation For Diffuse Large B-Cell Lymphoma–Type Richter Syndrome, Alex F. Herrera, Shalini Shenoy, Et Al

Open Access Publications

No abstract provided.

Benzopyrazine-Based Small Molecule Inhibitors As Trypanocidal And Leishmanicidal Agents: Green Synthesis, In Vitro, And In Silico Evaluations, Jonathan Rock, Daniel Garcia, Omar Espino, Shaila A. Shetu, Manuel J. Chan-Bacab, Rosa Moo-Puc, Navin B. Patel, Gildardo Rivera, Debasish Bandyopadhyay

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

World Health Organization (WHO) identified twenty tropical disease categories as neglected tropical diseases (NTDs)1. Chagas’ disease (also known as American trypanosomiasis) and leishmaniasis are two major classes of NTDs. The total number of mortality, morbidity, and disability attributed each year due to these two categories of diseases in magnitudes is much higher than the so-called elite diseases like cancer, diabetes, AIDS, cardiovascular and neurodegenerative diseases. Impoverished communities around the world are the major victim of NTDs. The development of new and novel drugs in the battle against Chagas’ disease and leishmaniasis is highly anticipated. An easy and straightforward …

Simulation On Aviation Maintenance Support System Based On Goal-Driven, Jiping Cong, Lijie Cui, Ding Gang, Ren Bo

Journal of System Simulation

Abstract: Aiming at the large investment and long time for optimization in aviation maintenance support model practice, for the first time, based on Netlogo platform, the multi-agent aviation maintenance support simulation system is constructed, which provides a reference to adapt the current support tasks and improve the evaluation efficiency. Selecting the annual mission flight time, echelon status, aircraft intact rate, and mission completion rate as the goal drivers, the simulation on different aviation maintenance support process is carried out, which displays the changes in flight arrangements, aircraft status, personnel, support equipment, etc. The simulation experiment shows that the multi-agent …

Minireview On Self-Healing Polymers: Versatility, Application, And Prospects, Md. Wasikur Rahman, Nawrin Rahman Shefa

Mechanical Engineering Faculty Publications

Nature is blessed with self-healing properties. Mimicking nature is a traditional practice to innovate new classes of materials for researchers. In this practice, researchers made a revolutionary approach to innovate self-healing polymer (SHP) that can be used to treat damage-related losses. Different SHPs with various properties have been developed for a wide range of applications. SHPs unlocked the key to the taste of real life through their application and versatility in the sectors close to our day-by-day life of this age and the near future. In this study, we reviewed the scopes and prospects of the application of SHPs owing …

A Structural Study Of The Cytoplasmic Chaperone Effect Of 14-3-3 Proteins On Ataxin-1, Seppe Leysen, Rebecca Jane Burnley, Elizabeth Rodriguez, Lech-Gustav Milroy, Lorenzo Soini, Carolyn J Adamski, Larissa Nitschke, Rachel Davis, Tomas Obsil, Lucas Brunsveld, Tom Crabbe, Huda Yahya Zoghbi, Christian Ottmann, Jeremy Martin Davis

Faculty, Staff and Students Publications

Expansion of the polyglutamine tract in the N terminus of Ataxin-1 is the main cause of the neurodegenerative disease, spinocerebellar ataxia type 1 (SCA1). However, the C-terminal part of the protein - including its AXH domain and a phosphorylation on residue serine 776 - also plays a crucial role in disease development. This phosphorylation event is known to be crucial for the interaction of Ataxin-1 with the 14-3-3 adaptor proteins and has been shown to indirectly contribute to Ataxin-1 stability. Here we show that 14-3-3 also has a direct anti-aggregation or "chaperone" effect on Ataxin-1. Furthermore, we provide structural and …

Determining Effective Drug Concentrations For Selection And Counterselection Genetics In Drosophila Melanogaster, Nick Matinyan, Yezabel Gonzalez, Herman A Dierick, Koen J T Venken

Faculty, Staff and Students Publications

We recently integrated into fly genetics a set of four selection and two counterselection markers and their corresponding drugs that can be used individually or in combination. These markers eliminate the need to visually screen progeny. Before using these markers in new genetic backgrounds, effective selection/counterselection concentrations should be established for each marker/drug combination. This protocol describes how to set up, perform, and analyze a drug titration curve to determine the effective selection/counterselection drug concentrations for their corresponding markers. For complete details on the use and execution of this protocol, please refer to Matinyan et al., 2021.