Energetic Tradeoffs, Infection, And Immunity In Wild Chimpanzees Of Uganda And Tanzania, Sarah Renee Phillips

Anthropology ETDs

Infectious disease is a primary source of mortality for most mammal species, but scientists have little understanding of factors driving variation in infection and immunity between individuals, populations, and species in the wild. Life history theory provides an evolutionary framework for delineating distribution of available energy to competing physiological demands, including growth, reproduction, and maintenance. Early life reproduction should be favored over late life survival, but, in long-lived species, reproductive success is strongly tied to survival to old age. Slower pace of reproduction could allow investment in immunity, reducing risk of morbidity and mortality to infectious disease. Additionally, several host …

Risk Factors For Poor Outcomes Among Patients With Extensively Drug-Resistant Tuberculosis (Xdr-Tb): A Scoping Review, Karan Varshney, Beverly Anaele, Matthew Molaei, Rosemary Frasso, Vittorio Maio

College of Population Health Faculty Papers

In recent years, there has been an upsurge in cases of drug-resistant TB, and strains of TB resistant to all forms of treatment have begun to emerge; the highest level of resistance is classified as extensively drug-resistant tuberculosis (XDR-TB). There is an urgent need to prevent poor outcomes (death/default/failed treatment) of XDR-TB, and knowing the risk factors can inform such efforts. The objective of this scoping review was to therefore identify risk factors for poor outcomes among XDR-TB patients. We searched three scientific databases, PubMed, Scopus, and ProQuest, and identified 25 articles that examined relevant risk factors. Across the included …

Cyclical And Intentional Activity Selection In Inquiry-Based Learning Improved By 5e Learning, Mitchell Miller

Dissertations, Theses, and Projects

The researcher investigated the attitudes toward inquiry-based learning and grades of students in middle school science as well as the significance of rubric based classroom discussion. The literature showed the researcher inquiry-based learning has been shown to increase engagement and understanding. The literature also showed classroom discussions were made more meaningful by implementation of expectations and a rubric. The researcher provided evidence of a significant improvement of classroom discussion, attitudes toward inquiry-based learning, and grades due to implementation of the actions taken by the researcher. The researcher used Kristine Bruss’s discussion rubric and expectations. The researcher also used Paul Anderson’s …

Attenuating Effect Of Vitamin E Against Silver Nano Particles Toxicity In Submandibular Salivary Glands, Mahmoud Bakr, Mahmoud Al Ankily, Sara M. Shogaa, Mohamed Shamel

Dentistry

Open AccessArticle

Attenuating Effect of Vitamin E against Silver Nano Particles Toxicity in Submandibular Salivary Glands

Restricted Microbial Presence, Activity, And Community Structuring Within Dry Valley Soils Of Antarctica, Scott Fillerup George

Theses and Dissertations

The McMurdo Dry Valley region is the largest ice-free area of Antarctica. Harsh abiotic conditions of the polar desert ecosystem, including extreme cold, aridity, and limited nutrient availability select for unique taxa. The comparatively simple terrestrial ecosystem is well-suited for investigating edaphic influences on microbial presence, activity, and community structuring. The Dry Valleys are viewed as a useful analog for Mars astrobiology investigations. However, most biotic investigations have been focused on lower elevations, where an understanding of edaphic effects on microbial communities within its generally more favorable conditions has emerged. Transiently wetted Dry Valley water tracks may be analogous to …

A New Criterion For Fluoroquinolone-Associated Disability Diagnosis: Functional Gastrointestinal Disorders, Deanna N. Cannizzaro, Lydia F. Naughton, Maya Z. Freeman, Linda Martin, Charles L. Bennett M.D., Ph.D., Cecilia Bove

Faculty Publications

Background and Objectives: Fluoroquinolones (FQs) are a broad-spectrum class of antibiotics routinely prescribed for common bacterial infections despite recent recommendations to use them only for life-threatening cases. In addition to their antimicrobial properties, FQs act in the central nervous system as GABAA receptor inhibitors, which could potentially affect functionality of the vagus nerve at the forefront of gastrointestinal (GI) tract function. Alterations in neural control of digestion have been shown to be linked to Functional Gastrointestinal Disorders (FGIDs), which are usually diagnosed based on self-reported symptoms. The aim of this study was to assess the incidence of FGIDs following FQ …

Stimming Expresses Empathy, Not To Be Masked Or Persecuted: A Scoping Review And Case Study Of The “Double-Empathy Problem” Solved By Recognizing The Autism Language, Kathryn Haas

Student Capstone Papers

This article critically examines autism and autistic stimming through the lenses of neurotypicals and autistics, evaluates confines currently imposed upon autistics by neurotypical society, and synthesizes what autistic leaders have expressed about their experiences striving for inclusion (Gernsbacher, 2017; Milton, 2012). Autistic-led studies are now at the forefront of the neurodiversity movement and are growing in fervor. The following themes were identified: (a) prevalence of autism, (b) the interpretation and measurement of empathy, (c) discovery of genetic factors transformed autistics’ identity, (d) publication of non-genetic factors such as vaccines undermined the legitimacy of the autism language, (e) the problem with …

Civic Environmental Stewardship: Aligning Organizational And Participant Motivations, Kathleen L. Wolf, Weston Brinkley, Dale J. Blahna

Cities and the Environment (CATE)

Natural area management and sustainability in cities is ever more reliant on civic environmental stewardship. Many conservation organizations sponsor stewardship programs that enlist volunteers to care for the land and restore urban ecosystems. Stewardship program success depends on alignment of individuals’ and sponsoring organizations’ goals. We conducted surveys with a sample of 165 volunteers across natural areas stewardship events in metropolitan King County (Washington, U.S.). An adapted Volunteer Functions Inventory framework was used to understand volunteers’ motivations, satisfactions, and volunteering history. Our findings confirmed the multidimensional dynamics of volunteerism, as stewardship volunteers were motivated and expressed satisfaction for practical altruism, …

Salt Marshes As Groundwater Buffers For Development: A Survey Of South Carolina Salt Marsh Basins, Alicia M. Wilson, Meghan Shanahan, Erik M. Smith

Faculty Publications

Salt marshes serve as zones of intense groundwater mixing and reaction between freshwater uplands and estuaries. This raises the question of whether the impacts of upland development on nutrient and carbon species can be transmitted through salt marshes via groundwater, or whether salt marshes can buffer estuarine waters from coastal development. We sampled groundwater from fifteen tidal creek basins in South Carolina to test for compositional differences associated with development and marsh width. Groundwater samples from near creekbanks and below freshwater uplands were analyzed for salinity, total dissolved nitrogen and phosphorus, and dissolved organic carbon. Analyses revealed significantly higher TDN …

Exploring The Biofilm Of Candida Auris As It Relates To Persistence In Clinical Setting And Susceptibility To Antimicrobials, Bethany Butts

Master of Science in Integrative Biology Theses

The rapid rise of drug-resistant pathogens is a global health concern. Known pathogens are acquiring resistance to many commonly used drugs, while new drug-resistant pathogens are emerging. These resistant pathogens are responsible for many healthcare-associated infections (HAI) [1, 2]. Candida auris is among these emerging drug-resistant pathogens, first described in 2009. The CDC labels C. auris at the highest level of global public health threat [3,4]. Effective methods of decolonization and control of the organisms have yet to be established, as it is resistant to many agents used for microbial control. Recent research has found that C. auris has the …

Impacts Of Social-Emotional Learning Via A Daily Writing Reflection In The Secondary Classroom, Angie Peterson

Dissertations, Theses, and Projects

The purpose of this qualitative study was to determine a time effective and subject area friendly way to address students’ social-emotional needs as a means to alleviate stress, communicate with teachers, and improve their overall wellbeing. Since the beginning of the COVID-19 pandemic, there have been many unforeseen or unaddressed repercussions that educators will continue to be dealing with as schools return to traditional formats or as they adjust to new ones. What impact can the use of daily journal writing have for high school students as an immediate and potentially long-term social-emotional learning or competency technique?

This study was …

Antipsychotic Medication Administration In Oregon Assisted Living/Residential Care Settings: Analyzing An Action Situation, Sarah Dys

Dissertations and Theses

Antipsychotic medication use (APU) in assisted living and residential care (AL/RC) settings is an under-studied and controversial health policy issue. APU in older adults with dementia is associated with an increased risk of falls, hospitalizations, and early mortality. I operationalize the Institutional Analysis and Development Framework using a situational analysis approach, an extension of grounded theory methods, to explore the APU in Oregon AL/RC settings. Regulatory deficiency citations, Oregon AL/RC population data, and semi-structured interviews suggest that staff role clarity, organizational characteristics, and perceived agency influence decision-making around APU. AL/RC providers and caregivers are forced to simultaneously balance and prioritize …

Comparing Macroinvertebrate Total Abundance And Total Biomass On Five Substrate Types From Upstream To Downstream On The North Branch Of The Au Sable River, Paul David Dingman

Masters Theses

The North Branch of the Au Sable River is located in the northern lower peninsula of Michigan and is known for prolific hatches of Ephemeroptera (mayflies), Trichoptera (caddisflies), and Plecoptera (stoneflies). Macroinvertebrates play an important role in processing and recycling organic material in rivers and are a valuable food source for trout. In 2018, anglers were reporting catching fewer numbers of brook and brown trout (Salmo trutta and Salvelinus fontinalis). The Michigan Department of Natural Resources (MDNR) determined significantly lower abundance than the historical average. We hypothesized that trout abundances were lower due to a lack of prey …

Phage Commander, An Application For Rapid Gene Identification In Bacteriophage Genomes Using Multiple Programs, Matt Lazeriff, Geordie Ryder, Sarah L. Harris, Philippos K. Tsourkas

Computer Science Faculty Research

The number of sequenced bacteriophage genomes is growing at an exponential rate. The majority of sequenced bacteriophage genomes are annotated by one or more of several freely available gene identification programs (Glimmer, GeneMark, RAST, Prodigal, etc.). No program has been shown to consistently outperform the others; thus, the choice of which program to use is not obvious. We present the Phage Commander application for rapid identification of bacteriophage genes using multiple gene identification programs. Phage Commander runs a bacteriophage genome sequence through nine gene identification programs (and an additional program for identification of tRNAs) and integrates the results within a …

Female Puma (Puma Concolor) Highway Crossings In The Yucatan Peninsula, Carlos A. López González, Fernanda Cruz Torres, Mircea G. Hidalgo Mihart

Western North American Naturalist

Human infrastructure, particularly highway infrastructure, has proven to be a hazard for the resilience of large felid populations throughout the world. The Yucatan Peninsula is no exception and is presently confronted with the establishment of the “Tren Maya,” a continental railway that will reshape the road network of the peninsula. We describe 12 successful crossings of a 4-lane highway on the peninsula by a female puma (Puma concolor) fitted with a GPS radio-transmitter. The median time between sequential locations was 24 h (range 8–56 h), and the average number of days between crossings was 4.33 (SD = 2.50). …

Identifikasi Molekuler Dan Uji Aktivitas Inhibitor Alfa Glukosidase Dari Bakteri Endofit Daun Afrika (Vernonia Amygdalina), Siti Nurfajriah, Maulin Inggraini, Noor Andryan Ilsan

Chimica et Natura Acta

Diabetes Mellitus (DM) adalah penyakit gangguan metabolik yang ditandai dengan tingginya kadar glukosa darah postprandial atau hiperglikemia. Hal ini disebabkan oleh sel ß pankreas tidak dapat menghasilkan insulin yang cukup atau tubuh tidak dapat menggunakan insulin yang dihasilkan secara efektif. Pengendalian hiperglikemia merupakan hal penting dalam terapi pengobatan DM tipe 2. Salah satu caranya yaitu memberikan terapi inhibitor alfa glukosidase. Daun afrika (Vernonia amygdalina) merupakan tanaman yang berpotensi sebagai penghasil senyawa inhibitor alfa glukosidase. Penelitian ini bertujuan untuk mengisolasi dan menguji aktivitas inhibitor alfa glukosidase dari bakteri endofit daun afrika (Vernonia amygdalina) serta identifikasi molekuler bakteri yang menghasilkan inhibitor alfa …

Emotional Intelligence And Resonant Leadership: Investigating School Principals' Preparation And Professional Development In Response To Covid-19 And Other Challenges, Ashlie Kaye Miller

Dissertations and Theses

Research has shown that high levels of emotional intelligence and resonant leadership can reduce workplace stress and increase the health, wellness, satisfaction, and performance of employees. Many K-12 principals face a myriad of challenges that tend to produce chronic stress, including the recent Covid-19 pandemic. Yet, it is unclear how the preparation and professional development (PPD) programs available to principals incorporate and encourage resonant leadership practices that are needed to effectively cope with these challenges. This study used an explanatory sequential mixed methods design to examine the perceptions of K-12 principals in Oregon regarding: (a) their needs and challenges, especially …

Ecological Exposure And Effects Of Microplastics In Crabs Along The Pacific Coast, Dorothy A. Horn

Dissertations and Theses

Microplastics have been documented across the global oceans as an ubiquitous pollutant. Found in the water column, sediment, shorelines, estuaries, freshwater streams and rivers along with terrestrial soils, flora and fauna. The continuous input of plastic waste into the marine environment doesn't seem to be slowing as the amount of plastic created each year increases globally.

This study investigated (1) the effects of microplastic ingestion in the indicator species, the Pacific mole crab (Emerita analoga), testing the predator avoidance behavior, reproductive output and parasitism effects when an adult female gravid crab had ingested microplastics (2) adult mortality, hatching …

Nature-Based Solutions In Environmental Planning: Ecosystem-Based Adaptations, Green Infrastructures, And Ecosystem Services To Promote Diversity In Urban Landscapes, Lorena Alves Carvalho Nascimento

Dissertations and Theses

Nature-based solutions encompass strategies that explore ecosystem-based adaptations, green infrastructures, and ecosystem services in environmental planning and landscape management. However, nature-based solutions do not always consider ecological values and perspectives from Black, Indigenous, and Global South population. This dissertation has three independent papers that explore the application of ecosystem-based adaptations, green infrastructures, and ecosystem services in communities unheard by environmental planning agencies. The first paper is a conceptual framework that used literature review and observations of current human-nature interactions to reflect how the criminalization, acculturation, and cultural appropriation of cultural ecosystem services have burdened Black and Indigenous identities. Recommendations for …

Climate Mitigation Through Biological Conservation: Extensive And Valuable Blue Carbon Natural Capital In Tristan Da Cunha’S Giant Marine Protected Zone, David K.A. Barnes, James B. Bell, Amelia E. Bridges, Louise Ireland, Kerry L. Howell, Stephanie M. Martin, Chester J. Sands, Soto A Mora, Terri Souster, Gareth Flint, Simon A. Morley

School of Biological and Marine Sciences

Carbon-rich habitats can provide powerful climate mitigation if meaningful protection is put in place. We attempted to quantify this around the Tristan da Cunha archipelago Marine Protected Area. Its shallows (<1000 m depth) are varied and productive. The 5.4 km2 of kelp stores ~60 tonnes of carbon (tC) and may export ~240 tC into surrounding depths. In deep-waters we analysed seabed data collected from three research cruises, including seabed mapping, camera imagery, seabed oceanography and benthic samples from mini-Agassiz trawl. Rich biological assemblages on seamounts significantly differed to the islands and carbon storage had complex drivers. We estimate ~2.3 million tC are stored in benthic biodiversity of waters <1000 m, which includes >0.22 million tC that can be sequestered (the proportion of the carbon captured that is expected to become buried in sediment or locked away in skeletal tissue for at least 100 years). Much of this carbon is captured by cold-water coral reefs as a mixture of inorganic (largely calcium carbonate) and organic compounds. As part of its 2020 Marine Protection Strategy, these deep-water reef systems are now protected by …

Regulation Of P53 And Cancer Signaling By Heat Shock Protein 40/J-Domain Protein Family Members., Atsushi Kaida, Tomoo Iwakuma

Manuscripts, Articles, Book Chapters and Other Papers

Heat shock proteins (HSPs) are molecular chaperones that assist diverse cellular activities including protein folding, intracellular transportation, assembly or disassembly of protein complexes, and stabilization or degradation of misfolded or aggregated proteins. HSP40, also known as J-domain proteins (JDPs), is the largest family with over fifty members and contains highly conserved J domains responsible for binding to HSP70 and stimulation of the ATPase activity as a co-chaperone. Tumor suppressor p53 (p53), the most frequently mutated gene in human cancers, is one of the proteins that functionally interact with HSP40/JDPs. The majority of p53 mutations are missense mutations, resulting in acquirement …

Phase 3 Safety And Efficacy Of Azd1222 (Chadox1 Ncov-19) Covid-19 Vaccine, Ann R Falsey, Magdalena E Sobieszczyk, Ian Hirsch, Stephanie Sproule, Merlin L Robb, Lawrence Corey, Kathleen M Neuzil, William Hahn, Julie Hunt, Mark J Mulligan, Charlene Mcevoy, Edwin Dejesus, Michael Hassman, Susan J Little, Barbara A Pahud, Anna Durbin, Paul Pickrell, Eric S Daar, Larry Bush, Joel Solis, Quito Osuna Carr, Temitope Oyedele, Susan Buchbinder, Jessica Cowden, Sergio L Vargas, Alfredo Guerreros Benavides, Robert Call, Michael C Keefer, Beth D Kirkpatrick, John Pullman, Tina Tong, Margaret Brewinski Isaacs, David Benkeser, Holly E Janes, Martha C Nason, Justin A Green, Elizabeth J Kelly, Jill Maaske, Nancy Mueller, Kathryn Shoemaker, Therese Takas, Richard P Marshall, Menelas N Pangalos, Tonya Villafana, Antonio Gonzalez-Lopez

Faculty, Staff and Student Publications

BACKGROUND: The safety and efficacy of the AZD1222 (ChAdOx1 nCoV-19) vaccine in a large, diverse population at increased risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the United States, Chile, and Peru has not been known.

METHODS: In this ongoing, double-blind, randomized, placebo-controlled, phase 3 clinical trial, we investigated the safety, vaccine efficacy, and immunogenicity of two doses of AZD1222 as compared with placebo in preventing the onset of symptomatic and severe coronavirus disease 2019 (Covid-19) 15 days or more after the second dose in adults, including older adults, in the United States, Chile, and Peru.

RESULTS: …

Molecular Mechanisms Of Aberrant Protein Glycosylation In Pancreatic Cancer Stemness And Metastasis, Frank Leon

Theses & Dissertations

A myriad of genetic and other abnormal changes underlies the aggressiveness and dissemination properties observed in pancreatic cancer (PC). Aberrant protein glycosylation is a commonly observed feature in PC. The modification of protein O-glycosylation is mediated by glycosyltransferases, which attach and sequentially elongate monosaccharides on Serine/Threonine (Ser/Thr) motifs. Aberrant glycosylation is recognized as an emerging hallmark of cancer where a disruption in normal glycosylation results in irregular O-glycans.

This dissertation research has investigated the consequences of aberrant protein glycosylation on stemness and enhancement of metastatic properties in pancreatic ductal adenocarcinoma (PDAC). Several publications have reported aberrant O-glycosylation increases in oncogenic …

Management Of Meadow Fescue Pasture For High-Producing Dairy Cows In Northern Japan, K. Sudo, K. Ochiai, T. Ikeda

IGC Proceedings (1977-2023)

The objective of this study was to establish an intensive grazing system of meadow fescue (Festuca elatior L.) pasture for high-producing dairy cows in some areas of Japan where soil freezes in winter. Plant succession of meadow fescue pastures that had been grazed at different plant heights and milk production from cows grazed on meadow fescue pasture compared to that from cows grazed on perennial ryegrass pasture were surveyed over a five year period. Succession of meadow fescue pasture depended on the management of plant height before grazing use. Milk production from cows grazed on meadow fescue pasture was …

Leaf Blade Selection By Sheep In Kleingrass (Panicum Coloratum L.) Pastures With Different Deferment Periods, P. Sierra, M. S. Cid, M. A. Brizuela, C. M. Ferri

IGC Proceedings (1977-2023)

The winter use of standing dead biomass produced by warm season grasses during the previous growing season may be an alternative to grazing systems in the semi-arid Pampean Region of Argentina. This study evaluated: 1) the effect of different deferment periods on the leaf blade percentage and quality of ‘kleingrass’ (Panicum coloratum L.), a warm season specie recently introduced to that region, and 2) whether rams grazing the vegetation accumulated during these different periods are able to select leaf blades to maintain the quality of their diets. It was generated three treatments by deferment of the forage produced after …

Microhistological Estimation Of Leaf Blade Percentage In Diets From Monoespecific Pastures, P. Sierra, M. S. Cid, M. A. Brizuela, C. M. Ferri

IGC Proceedings (1977-2023)

Although a decrease in the leaf-stem ratio affects the nutritive value of pastures, herbivores can reinforce selection for leaf blades to maintain the quality of their diets. This study evaluated whether the percentage of fragments with furrows in blades could be used to estimate the relative intake of this part of the leaves by herbivores grazing monoespecific pastures. It was worked with vegetation of kleingrass (Panicum coloratum L.) from paddocks with three deferment periods. Blade samples, and different plant part mixtures hand compounded were in vitro digested. The digestion residues were microhistological analyzed determining the number of fragment with …

Evaluation Of Kentucky Bluegrass (Poa Pratensis L.) For Creating Sustainable Grazing Swards In Hokkaido, T. Saigusa, S. Tejima, Y. Ogawa, S. Takahashi

IGC Proceedings (1977-2023)

Kentucky bluegrass (Poa pratensis L.) is generally considered to be a weed in the meadows of Hokkaido. However, a revaluation of this species should be undertaken in terms of its useful characteristics for labor-saving management on farms in marginal areas. The performance of steers (Holstein-Friesian) and botanical composition of Kentucky bluegrass swards were investigated under the stocking methods of set and rotational grazing and compared with timothy (Phleum pratense L.) swards. Kentucky bluegrass was stable over the grazing season under both methods, although timothy decreased rapidly. The average daily gain of steers raised on Kentucky bluegrass swards was …

Take That Covid! Positive Documents Emerging From The Museum Sector, Kiersten F. Latham, Katherine F. Jaede

Proceedings from the Document Academy

Although the field of museology has discussed many concepts found in other positive disciplines, such as flow in positive psychology, the field itself has not yet developed a purposeful framework for positive museology. A long history of research in museum studies and on museal endeavors reveals aspects of a positive approach already exist but have yet to be woven together into a synthetic whole. In 2020-2021, during the COVID-19 pandemic, museums themselves showed their positive strengths and virtues through documents such as social media and field-wide communication, revealing their capacity for a positive approach. This paper uses a developing framework …

The Documentality Of “Smong” As Social Control For Disaster Risk Reduction In Simeulue Island, Rusdan Kamil, Dian Novita Fitriani, Niswa Nabila Sri Bintang Alam, Zulfatun Sofiyani

Proceedings from the Document Academy

Aim – This study aims to analyze nandong smong as an oral tradition with the documentality approach by Frohmann.

Design/Methodology/Approach – This study analyzes nandong smong using qualitative method, especially case study research. The data collected in this study used secondary data obtained from literature sources or journal documents and previous research related to nandong smong. In this research, data analysis document analysis.

Finding – Nandong smong is one of the oral traditions that has become a disaster mitigation tool for the people of Simeulue. According to Frohmann's concept of documentality, Nandong Smong has four aspects of documentality, as …

Positive Psychological Transformation: A Mixed Methods Investigation Into Catalysts And Processes Of Meaningful Change, Nick Fortino, Paul Dommert Jr., Nadia Santiago, Jen Smith

International Journal of Transpersonal Studies Advance Publication Archive

This mixed methods study investigated the experience of positive psychological transformation, including its catalysts, dynamics, supportive factors, and outcomes. The first phase of the study was a 13-item survey (N=130) that revealed trends and associations in participants’ experiences of transformation. The most significant correlation was between “expressing myself” and change stabilization (p < .01). Forty-four percent of participants reported trauma or emotional distress as the main catalyst of their transformation. Each of the other three main catalysts (dissonance, adaptation, and inspiration) drew approximately 18% of responses. Connecting with nature (71%), introspection (65%), solitude (63%) and empathy (61%) were commonly reported supportive factors. Common changes related to participants’ way of interacting with others (77%), perception (75%), and emotional patterns (70%). The process of transformation differed substantially depending on multiple factors including the catalyst and demographic categories. Additionally, the survey revealed a trend of moving away from organized religion toward a sense of being spiritual but not religious. The second phase of the study consisted of interviews with a portion of the participants who reported trauma as the main catalyst of their transformation (n = 26) and was focused on the experience of posttraumatic growth. Thematic analysis revealed that transformation is typically initiated by a series of traumatic events and that the process of transformation can involve impaired well-being/functioning before elevated well-being/functioning. The results of thematic analysis were consistent with existing data on posttraumatic growth.