Digital Commons Network^™

A Novel Model To Study Adipose-Derived Stem Cell Differentiation, Austin N. Worden

Theses and Dissertations

The use of three-dimensional (3D) culture systems (hydrogels) and adipose-derived stem cells (ADSCs) in regenerative medicine to advance early-stage investigation and modeling of the mechanisms of diseases, treatments, targets, etc. has recently increased. ADSCs, specifically, are utilized due to their innate programming during embryogenesis and in adult tissues in addition to their ability to differentiate into mesodermal, endodermal, and ectodermal cell-specific lineages. Of importance is that these advancements do not involve a model specimen (i.e. mice or rats) and simulate the numerous conflicting signals a migrating cell is exposed to in vivo such as chemokines, extracellular matrix (ECM), growth factors, …

Multi-Fidelity Surrogate And Reduced-Order Model-Based Microfluidic Concentration Gradient Generator Design, Haizhou Yang

Theses and Dissertations

The microfluidic concentration gradient generator (μCGG) is an important device to generate and maintain concentration gradients (CGs) of biomolecules for understanding and controlling biological processes. However, determining the optimal operating parameters of μCGG is still a significant challenge, especially for complex CGs in cascaded networks. To tackle such a challenge, this study presents multi-fidelity surrogate and reduced-order model-based optimization methodologies for accurate and computationally efficient design of μCGGs.

The surrogate-based optimization (SBO) method is first proposed for the design optimization of μCGGs based on an efficient physics-based component model (PBCM). Various combinations of regression and correlation functions in Kriging and …

The Influence Of Adhd On Concussion In Ncaa College Athletes, Brett Steven Gunn

Theses and Dissertations

Evidence suggests attention deficit/hyperactivity disorder (ADHD) may be associated with an increased incidence of concussion; however, no study has cross-sectionally (Aim 1) and longitudinally (Aim 2) assessed the associations of ADHD with concussion. Additionally, there is reason to expect cognitive alterations following concussion in athletes with ADHD. Further, there is currently no study that has evaluated the influence of common medications often taken to mitigate some symptoms of ADHD, such as methylphenidate and amphetamines. Therefore, we sought to longitudinally assess cognitive profiles (Aim 3) of athletes with ADHD taking medication (ADHD+Rx) and not taking medication (ADHD_uRx) at baseline, 24-48 hours …

Let’S Be Friends: Examining Consumer Brand Relationships Through The Lens Of Brand Personality, Engagement, And Reciprocal Altruism, Daniel D. Haun

Theses and Dissertations

Brands have always exuded personality and status to consumers in order to promote a competent impression and induce positive perceptions and behaviors (Griskevicius, et al., 2007). In order for individuals to identify with brands, the brands must become more personable by consciously embodying a specific personality trait. Research has found that when a brand embodies a personality, there is an associated increase in consumer preference and usage (Sirgy, 1982), purchase choices for that brand (Ha & Janda, 2014; Gordon et al., 2016; Guèvremont & Grohmann, 2013; Swaminathan et al., 2009), and consumer preference and brand loyalty (Louis & Lombart, 2010; …

Polymeric Sorbents For Solid-Phase Extraction (Spe) Of Polar Analytes And Carbon Dioxide Capture, Ishwor Karki

Theses and Dissertations

The main topics of this dissertation are: 1) the study of hydrophilic-lipophilic balance (HLB) polymer monoliths for solid-phase extraction (SPE) applications, 2) molecularly imprinted polymers (MIPs) for capturing the CO2 gas and 3) the application of symmetry-adapted perturbation theory (SAPT) calculations to examine the origins of non-covalent interactions.

HLB polymers are popular sorbent materials in separation science. The Divinylbenzene-co-N-vinylpyrrolidone (DVB-co-NVP) polymer is one of the most widely used general-purpose HLB polymers. Despite the popularity of HLB polymer stationary phases, the studies of the adsorption properties of DVB-co-NVP have only been reported over a narrow …

Utilization Of Remote Sensing To Analyze Aedes Mosquito Egg Abundance With Combined Weather Variables In Two Southeastern Coastal Cities, Danielle M. Johnson

Theses and Dissertations

Several vector-borne diseases have recently resurfaced, and many have suddenly spread to new areas in the United States (U.S.) due to climate change and tropicalization. Two vectors of public health importance are Aedes aegyptiand Aedes albopictus. The Southeastern region of the U.S. appears to be a preferential ecological niche for both Aedes species. Aedes aegyptiand Aedes albopictus are highly susceptible to environmental conditions, such as humidity, precipitation, temperature. Remote sensing technology has proven to be useful for estimating vector populations. Miami-Dade County is an established hotspot for disease transmission. Charleston County is newly vulnerable due to similar …

Robot Area Coverage Path Planning In Aquatic Environments, Nare Karapetyan

Theses and Dissertations

This thesis is motivated by real world problems faced in aquatic environments. It addresses the problem of area coverage path planning with robots - the problem of moving an end-effector of a robot over all available space while avoiding existing obstacles. The problem is considered first in a 2D space with a single robot for specific environmental monitoring operations, and then with multi-robot systems — a known NP-complete problem. Next we tackle the coverage problem in 3D space - a step towards underwater mapping of shipwrecks or monitoring of coral reefs.

The first part of this thesis leverages human expertise …

Task-Based, Learner-Centered Language Instruction: Educational Innovation In An Adult Foreign Language Program, Clayton D. Leishman

Theses and Dissertations

This study involved educational innovation and implementation of a task-based, learner-centered curriculum within a foreign language program. The concerns-based assessment model (originally proposed by Hall et al., 1973, and further developed by Hall & Hord, 1987; 2011) was used to investigate the degree to which language instructors adopted the innovation. An adapted form of the concerns-based assessment model’s levels of use focused interviews and instructional artifacts were used to measure the level of implementation of the task-based approach. Analysis of the data identified categoricalchanges as instructors implemented the new curriculum. The category of sharing revealed higher levels of use due …

Assessing Longitudinal Impacts Of Mentor Role On Student Outcomes, Jody Lanza-Gregory

Theses and Dissertations

Most youth form relationships with extra-familial adults, sometimes called natural mentoring relationships, and these connections appear to benefit youth in several ways. Previous research demonstrates that the presence of a mentor can positively impact student outcomes including educational expectation, educational attainment, and social success. However, little research has considered how the impact of a natural mentorship may differ based upon the role of the adult in the youth’s life. Using data from three waves of the National Longitudinal Study of Adolescent Health, this study investigates if the role of a mentor (i.e. teacher, coach, religious leader) influences the types of …

Satellite Observations And Spatiotemporal Assessment Of Salt Marsh /Dieback Along Coastal South Carolina (1990-2019), Huixuan Li

Theses and Dissertations

Coastal wetland mapping is often difficult because of the heterogeneous vegetation compositions and associated tidal effects. Past studies in the Gulf/Atlantic coast states have reported acute marsh dieback events in which marsh rapidly browned and thinned, leaving stubble of dead stems or mudflad with damaged ecosystem services. Reported marsh dieback in South Carolina (SC), USA, however, have been limited. Previous studies have suggested a suite of possibly abiotic and biotic attributes responsible for salt marsh dieback. However, there are no consensus answers in current literature explaining what led to marsh dieback in past decades, especially from the spatiotemporal perspective. In …

Unf Journal Fall 2021, University Of North Florida

UNF Journal

A university periodical for alumni and friends of the University of North Florida.

A Clarified Standard? A Case Note On Monasky V. Taglieri, Rebecca Jacobson

Cardozo Law Review

No abstract provided.

Variations In Er Stress And Unfolded Protein Response Predict Disease Susceptibility, Youwen Zhang

Theses and Dissertations

Numerous studies linked endoplasmic reticulum (ER) stress and unfolded protein response (UPR) to physiological responses to stress and various human pathologies, including metabolic disorders. Although variability in stress responses among individuals has been widely recognized, how such variations in the UPR affect susceptibility to diseases remains unknown. Using outbred deer mice as a model, we explored the consequences of the differential propensity to UPR at the transcriptomic, cellular, and organismic level.

Initially, we analyzed the correlation between several UPR-related genes in primary fibroblasts, at the whole transcriptome level, after ER stress induction. The analysis of correlated transcripts revealed that their …

The Development Of Novel Cdk8 And Cdk19 Inhibitors And Degraders As Potential Anti-Cancer Agents, Li Zhang

Theses and Dissertations

CDK8 and its homolog CDK19 are essential for transcription regulation and their dysregulation has been identified in numerous diseases, especially in cancers. CDK8 and CDK19 have been implicated in cancer development through their kinase activity and kinase independent functions. Despite the existing CDK8/19 inhibitors, there is still a need to develop novel CDK8/19 inhibitors with improved potency and PK profile. It is also necessary to develop CDK8/19 degraders that are able to eliminate the kinase-independent functions. Although two CDK8-degrading PROteolysis Activating Chimeras (PROTACs) have been reported, they have limited CDK8 degradation efficacy and no effect on CDK19. PROTACs with improved …

The Effect Of Low Dose Penicillin On Tumor Development In ApcMin/+ Mice, Kinsey Ann Sierra Meggett

Theses and Dissertations

Antibiotics have been our most effective weapon against bacterial infections since their discovery in the early 1900s. Their use has been critical in reducing mortality rate from infectious diseases. However, in the last few decades, the overuse of antibiotics, beginning at an early age and into adulthood, has become a growing concern globally. Penicillin is one of many extensively used antibiotics in early childhood that has been used to treat childhood infections. Recent studies showed that exposure to low dose penicillin can have adverse effects leading to chronic illness such as diabetes, allergies, inflammation, and susceptibility to obesity, with the …

Redbird Scholar, Vol. 7, No. 1 (Fall 2021), Illinois State University, Office Of The Vice President For Research And Graduate Studies

Redbird Scholar

No abstract provided.

Multiple Sclerosis And Its Symptom Management Through Supplementation And Dietary Planning, Lindsey J. Davis

Selected Honors Theses

Multiple Sclerosis (MS) is an autoimmune, neuroinflammatory disorder that is characterized by the breakdown of myelinated axons in the Central and Peripheral Nervous Systems. It is a potentially debilitating autoimmune disease that affects almost 1 million people in the United States, and nearly 2.5 million people worldwide. The precise etiology of MS is still being researched, but much progress has been made towards understanding the molecular mechanisms and impactful ways to treat this disease. While there is still no cure, new treatment plans are constantly being orchestrated in effort to alleviate the burden that MS carries. Combination treatment plans have …

Establishing Trauma-Informed Practices Within The Early Learning Environment, Daria M. Castor

Selected Honors Theses

Nearly half of US children have experienced one or more types of serious trauma with rates continually increasing. Early childhood educators get a first-hand encounter with childhood trauma as it affects the learning and behavior of young students. Young children process their trauma differently whether that be through behavioral issues or a withdrawn demeanor. Building strong, positive relationships with students and creating a safe learning environment are practical methods used by educators when working with traumatized young learners, however there is much more to be done to best meet the needs of these students. This thesis emphasizes the detrimental effects …

Understanding The Educational Landscape: A Comparative Study Of Public, Alternative, And Montessori Models, Elizabeth Dykens

Selected Honors Theses

This thesis intends to demonstrate the relevance and significance of alternative education within today’s educational climate. First, the literature review traces the historical backdrop of the American public school system and the founding fathers’ original purposes for education. It explores the shifts in policy and pedagogy that have led to current models and methods of education. Then, the literature review focuses on alternative educational philosophies, with an emphasis on the Montessori Method, and why they not only address the critiques of the public system but also better align with a child’s nature and development. The study backing this thesis lays …

An Inside View: Gendered Perspectives On Freedom In Decameron 7.5, Brittany Asaro

Italian and Italian Studies: Faculty Scholarship

No abstract provided.

Regulating During Emergencies, Michael Barsa, David Dana

NULR Online

No abstract provided.

Evaluation And Validation Of Hf Radar Swell And Wind Wave Inversion Method, Zaid R. Al-Attabi, George Voulgaris, Daniel C. Conley

School of Biological and Marine Sciences

AbstractAn examination of the applicability and accuracy of the empirical wave inversion method in the presence of swell waves is presented. The ability of the method to invert Doppler spectra to wave directional spectra and bulk wave parameters is investigated using one-month data from a 12 MHz WERA High Frequency (HF) radar system and in-situ data from a wave buoy. Three different swell inversion models are evaluated: LPM (Lipa et al. 1981), WFG (Wang et al. 2016) and EMP, an empirical approach introduced in this study. The swell inversions were carried out using two different scenarios: (1) a single beam …

Settingsorder Article Reprints Open Accessarticle Generation And Characterization Of Human Mesenchymal Stem Cell-Derived Smooth Muscle Cells, Srikanth Sivaraman, Jackson Hedrick, Samia Ismail, Chris Slavin, Raj R. Rao

Biomedical Engineering Faculty Publications and Presentations

Cardiovascular diseases are the leading cause of death worldwide. A completely autologous treatment can be achieved by using elastogenic mesenchymal stem cell (MSC)-derived smooth muscle cells (SMC) at the affected tissue site of vascular diseases such as abdominal aortic aneurysms (AAA). Thus, our work focused on evaluating the efficacy of (a) the combination of various growth factors, (b) different time periods and (c) different MSC lines to determine the treatment combination that generated SMCs that exhibited the greatest elastogenicity among the tested groups using Western blotting and flow cytometry. Additionally, total RNA sequencing was used to confirm that post-differentiation cells …

Desirability Of Outcome Ranking For The Management Of Antimicrobial Therapy (Door Mat) Reveals Improvements In The Treatment Of Bloodstream Infections Caused By Escherichia Coli And Klebsiella Pneumoniae In Patients From The Veterans Health Administration, Federico Perez, Brigid M. Wilson, Elie Saade, Robin L.P. Jump, Robert A. Bonomo

Faculty Scholarship

Background: Reductions in the use of broad-spectrum antibiotics is a cornerstone of antimicrobial stewardship. We aim to demonstrate use of the Desirability of Outcome Ranking Approach for the Management of Antimicrobial Therapy (DOOR MAT) to evaluate the treatment of Escherichia coli and Klebsiella pneumoniae bloodstream infections in patients from the Veterans Health Administration (VHA) across a decade. Methods: Using electronic records, we determined empiric and definitive antibiotic treatments, clinical characteristics, and 30-day mortality of patients with monomicrobial E. coli and K. pneumoniae bloodstream infections hospitalized in VHA medical centers from 2009 to 2018. Focusing on patients treated with parenteral β-lactams …

2021 Summer/Fall Newsletter, Plaster Creek Stewards

Newsletters

Highlights:

Summer Supercrew

Plaster Creek Hike + Discovery

Green Team

Diversity Training

Visit with Chariman Ron Yob

Fall Event: Environmental Justice in Our Watershed

Planting Partners

Curb Cut Rain Garden Highlight

African American Teachers' Experiences Of Becoming A Teacher In Ohio: A Case Study, Feon M. Battiste

Electronic Theses and Dissertations

There has been a hiring discrepancy in the recruiting and hiring process of African American teachers in Ohio (Stein, 2019). The purpose of this descriptive case study was to explore African American teachers’ experiences of becoming teachers in Ohio and their suggestions for improving the hiring process. Five research questions guided the study: (a) What were African American teachers’ lived experiences of becoming a teacher in Ohio? (b) How do African American teachers perceive the obstacles and catalysts of becoming and remaining teachers in Ohio? (c) How do African American teachers view diversity in the teaching force? (d) What policies …

Reducing Parental Stress In Neonatal And Pediatric Intensive Care Units, Nancy M. Abbene

Electronic Theses and Dissertations

Abstract

The neonatal intensive care unit (NICU) and pediatric intensive care unit (PICU) are highly operational and highly active environments. Health care workers must react quickly to care for patients and provide life-saving measures fundamental to favorable patient outcomes. Caregivers of this critical patient population are often overlooked as the healthcare team prioritizes patient’s needs. In addition, medical equipment, machines, and monitors have multiple safety alarms sounding frequently and contributing to high levels of parental stress upon their child’s admission to the NICU and PICU. Lack of giving adequate prominence to the value of caregiver support services in the hospital …

Montana Kaimin, Fall 2021, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula. This special issue was published in fall 2021.

Fulcrum, Newsletter Of The Furman University Libraries. Issue 16, Kathy Hamlin

Libraries Institutional Records

Table of Contents

• From the Director
• Welcome Archivist/Digital Collections Librarian, Dr. Nashieli Marcano
• Jean Wynn Smith: April 6, 1941 - November 5, 2021
• Interdepartmental News from Digital and Resource Management & Outreach and Access Services
• International Education Week. November 14-20
• Special Collections and Archives: "Newly Acquired, 1699 Galileo", "Top Google Rankings!", "Presidential Autograph Collection"
• Library and Information Technology Committee
• Team Engage. Enlighten. Overpower
• Library Student Advisory Group - Where Students' Voices are Heard
• CLP - How Did Sex Come to be Seen as Binary

High Value Correlates Of Caregiver Reported Counseling Service Need And Utilization For Adolescents At-Risk For Childhood Maltreatment And Neglect, Alejandro L. Vázquez, Tommy Chou, Cynthia M. Navarro Flores, Tyson S. Barett, Miguel T. Villodas, Melanie M. Domenech Rodríguez

Psychology Faculty Publications

Adolescents with a history of child maltreatment experience increased risk for psychopathology that sets them on a trajectory towards a range of difficulties in adulthood. Various factors influence caregivers’ decisions to seek mental health services (MHS) that could improve developmental outcomes. The present study applied a machine learning algorithm, elastic net, to a sample of 878 adolescent-caregiver dyads from the Longitudinal Studies of Child Abuse and Neglect. Analyses simultaneously examined a large number of factors to determine their ability to discriminate between caregivers who perceived a need for MHS and those who did not, as well as caregivers who utilized …