Digital Commons Network^™

A Docked Mutation Phenocopies Dumpy Oblique Alleles Via Altered Vesicle Trafficking, Suresh Kandasamy, Kiley Couto, Justin Thackeray

Biology

The Drosophila extracellular matrix protein Dumpy (Dpy) is one of the largest proteins encoded by any animal. One class of dpy mutations produces a characteristic shortening of the wing blade known as oblique (dpyo), due to altered tension in the developing wing. We describe here the characterization of docked (doc), a gene originally named because of an allele producing a truncated wing. We show that doc corresponds to the gene model CG5484, which encodes a homolog of the yeast protein Yif1 and plays a key role in ER to Golgi vesicle transport. Genetic analysis is consistent with a similar role …

University Of Richmond Magazine, Autumn 2021

University of Richmond Magazine

The University of Richmond's Alumni Magazine was first published as The Alumni Bulletin in 1936 and continues to this day as the University of Richmond Magazine.

Stand Dynamics And Diversity Patterns In Planted And Naturally Regenerating Urban Forests, Danica Anne A Doroski

Yale Graduate School of Arts and Sciences Dissertations

The world is becoming an increasingly urban planet with 68% of the global population expected to live in cities by 2050 and urban land cover expected to increase by 40%. This urban expansion brings with it a host of environmental and health consequences such as the urban heat island effect, reduced air and water quality, and biodiversity losses. In forested biomes, trees and forests growing within the urban matrix offer a valuable opportunity to offset many of these negative impacts and to provide a suite of additional benefits. In recognition of this opportunity, there is mounting interest in investing in …

Prognostic Implications Of Epidermal And Platelet-Derived Growth Factor Receptor Alterations In 2 Cohorts Of Idh, Iyad Alnahhas, Appaji Rayi, Maria Del Pilar Guillermo Prieto Eibl, Shirley Ong, Pierre Giglio, Vinay Puduvalli

Department of Neurology Faculty Papers

Background: Glioblastoma remains a deadly brain cancer with dismal prognosis. Genetic alterations, including IDH mutations, 1p19q co-deletion status and MGMT promoter methylation have been proven to be prognostic and predictive to response to treatment in gliomas. In this manuscript, we aimed to correlate other mutations and genetic alterations with various clinical endpoints in patients with IDH-wild-type (IDHwt) glioblastoma.

Methods: We compiled a comprehensive clinically annotated database of IDHwt GBM patients treated at the Ohio State University Wexner Medical Center for whom we had mutational data through a CLIA-certified genomic laboratory. We then added data that is publicly available from Memorial …

Korean Transnational Adoption As An Act Of Violence, Isabelle Titcomb , '22

Senior Theses, Projects, and Awards

Building on an emergent  eld of critical adoption studies, this paper traces the transformation of the Korean orphan into adoptee through the army camp, orphanage, women’s magazine, and family. In doing so, it demonstrates how Korean transnational adoption stood at the nexus of discourses concerning U.S. militarism, American consumerism, Cold War Orientalism, and white heternormative kinship formation. It concludes that adoption was not the radical act that its architects heralded it to be, rather it reproduced and rei ed pre-existing notions of race, gender, and sexuality founded in Orientalism.

Remembering “Der Noether”: The Gendered Image And Memory Of Women In Mathematics, Gwendolyn Rak , '22

Senior Theses, Projects, and Awards

German mathematician Emmy Noether (1882-1935) is known today for her contributions to abstract algebra and a 1918 theorem foundational to many theories of physics. She is also remembered as one of the most notable women mathematicians of the early 20th century and a significant figure in the history of women in science. Due to her position as an early female mathematician, her memory has been continually gendered in the decades since her death, reflecting the ways in which the image of the mathematician has frequently been constructed as heroic and masculine.

Climate Change Education Through A Social Justice Framework: A Necessary First Step Towards Solving The Climate Crisis, Leah Owen-Oliner , '22

Senior Theses, Projects, and Awards

No abstract provided.

The Power Of Translanguaging In American Schools, Tasneem Rattansi

School of Education and Leadership Student Capstone Projects

The concept of teaching English as a second language or multilingualism is something that the country has grappled with since the time of colonization. As we have become more aware of the globalization in our world, it has become quite evident that the basis of many of the theories and research conducted has a level of monolingual bias and is geared towards a system that is more fitting to what is known as monolingual norms. As more understanding is gained, the American education system is learning about translanguaging, an asset-based concept that is a heteroglossic ideology holding bilingualism to high …

The Power Of Language And Its Integral Role In Lgbtq+ Inclusion In Education, Jay Carr

School of Education and Leadership Student Capstone Projects

Abstract

Carr, J. (2021). The Power of Language and Its Integral Role in LGBTQ+ Inclusion in Education Language plays a central role in our daily lives; it is through language that we name, identify, and differentiate everyone and everything in our world. It is through language that dominant, heteronormative discourses have been established surrounding gender and sexuality. Heteronormativity positions heterosexual and cisgender (identifying with the sex / gender assigned at birth) identities as normal and natural, while excluding and oppressing LGBTQ+ (lesbian, gay, bisexual, transgender, queer / questioning, + other non-conforming identities) individuals. Despite a heavy push for ‘diversity’ and …

Permission Not Granted: A Domestic And Global Comparative Analysis On Social Media Policies, Privacy Laws And A Proposal For The United States, Simran Saini

Southern Illinois University Law Journal

Social media’s presence in people’s lives is more present today than it has ever been. While social media has many benefits to it, this specific means of communication has significant legal consequences associated with it as well, specifically users’ privacy concerns.

This note comparatively analyzes current data privacy laws within and outside the United States, while focusing on implications of these legislations on the popular social media platform, TikTok, by focusing on the recent class action: In Re TikTok. This note ends with a proposal for implementing a comprehensive federal data privacy regulation inspired by the European Union’s General Data …

Psychology 102: Introductory Psychology, Susan Austin

Open Educational Resources

Basic concepts and methods of contemporary psychology emphasizing the biological basis of behavior, learning, cognition, consciousness, development, stress and personality, abnormal behavior, group behavior, and social interaction.

Urgent Need For Integrated Pandemic Policies On Pathogen Spillover, Pallavi A. Kache, Sonila Cook, Nigel Sizer, Lee Hannah, Neil M. Vora

Publications and Research

No abstract provided.

Mad About The First Amendment, Our Beacon For Liberty, Equality And Democracy, Nicholas Allard

Faculty Scholarship

No abstract provided.

Reports And Commands: Deciphering A Health Exhibition Using The Speaking Mnemonic, David H. Lee

Publications and Research

The Amazing You exhibition at the Tampa Museum of Science and Industry had over 400 different multimedia health exhibits. Visitors walked through life stages, from conception through death, the exhibits at first showcasing developmental milestones, then diseases and chronic conditions associated with ageing. Museum executives described the exhibition as a public health intervention that stressed disease prevention, screening and behaviour change. This piece considers the question: What makes an exhibition be a health intervention? To describe complexities of the communication environment I use a mnemonic device called SPEAKING, an acronym for ‘Scene/Setting, Participants, Ends, Act Sequence, Key, Instrumentalites, Norms and …

Covid-19 Narratives From Anth 210, Demi Ruiz, Taylor De La Rosa, Hypatia Pine, Liz Witt, Jocelyn Jimenez

Oral Histories & Interviews

These selected works came from an extra credit assignment in the Fall 2021 ANTH 210 course taught by Gage Smith. The assignment was for students to write a scary story in the time of the pandemic and relate it to either the topic of religion or globalization.

• Halloween Story by Demi Ruiz
• A Scary Story in the Time of Pandemic: Religion vs a pandemic by Taylor De La Rosa
• A Scary Story in the Time of the Pandemic: Serial Murders and Ritualistic Killings During Unprecedented Times by Hypatia Pine
• My life during the COVID 19 pandemic by Liz Witt
• Celebrating …

"My Bewildering Brain Toils In Vain": Traumatic Brain Injury, The Criminal Trial Process, And The Case Of Lisa Montgomery, Alison Lynch, Michael L. Perlin, Heather Ellis Cucolo

Articles & Chapters

Individuals with traumatic brain injuries (TBI) have a greater risk of becoming justice-involved due to the role that many TBIs play in impulse control and judgment. Attorneys assigned to represent this cohort may not have encountered individuals with TBI before, and may not be familiar with behavioral manifestations that could be relevant as a defense or as mitigation in individual cases. In this regard, TBI is grossly misunderstood.

A grave example of this point, and a foundation for this article, is the case of Lisa Montgomery, who despite evidence of serious mental illness and significant brain damage, was convicted, sentenced …

Arcadia Magazine, 2021-10 2022-01

Alumni Magazine

No abstract provided.

Cosmc Deficiency Causes Spontaneous Autoimmunity By Breaking B Cell Tolerance, Junwei Zeng, Rajindra P. Aryal, Kathrin Stavenhagen, Chi Luo, Renyan Liu, Xiaohui Wang, Jiaxuan Chen, Hao Li, Yasuyuki Matsumoto, Yingchun Wang, Jianmei Wang, Tongzhong Ju, Richard D. Cummings

ETSU Faculty Works

Factors regulating the induction and development of B cell–mediated autoimmunity are not well understood. Here, we report that targeted deletion in murine B cells of X-linked Cosmc, encoding the chaperone required for expression of core 1 O-glycans, causes the spontaneous development of autoimmune pathologies due to a breakdown of B cell tolerance. BC-CosmcKO mice display multiple phenotypic abnormalities, including severe weight loss, ocular manifestations, lymphadenopathy, and increased female-associated mortality. Disruption of B cell tolerance in BC-CosmcKO mice is manifested as elevated self-reactive IgM and IgG autoantibodies. Cosmc-deficient B cells exhibit enhanced basal activation and responsiveness to stimuli. There is also …

Self-Management Experiences Of Community-Dwelling Adults With Chronic Obstructive Pulmonary Disease, Wendy S. Bauer

Dissertations

Chronic Obstructive Pulmonary Disease (COPD) is an incurable lung illness causing significant individual and public health burden. Individuals with COPD often experience high symptom burden, unpredictable exacerbations, numerous comorbid conditions, and frequent health care utilization. Self-management can improve health outcomes and reduce health care costs; however, many individuals with COPD struggle with effective self-management. Improving the self-management of individuals with COPD and the delivery of self-management support from health care providers is crucial to reducing the individual and societal costs of the illness.

The purpose of this study was to explore the self-management experiences of community-dwelling adults living with COPD …

Hspm 7431 – Public Health Practice Trends, Ho-Jui Tung

College of Public Health: Faculty Syllabi (2014-2021)

Today’s public health landscape is increasingly complex and constantly changing. This course focuses on emerging trends and challenges in public health practice that epitomize the increasing complexity and nature of challenges facing public health practitioners.

Pubh 3430: Sexuality Education, Helen Bland

College of Public Health: Faculty Syllabi (2014-2021)

“Explores contemporary issues in human sexuality and prepares future health professionals to conduct sexuality education with diverse populations in a variety of settings (i.e., school, community, or worksite). Content is intended to help students increase their knowledge of sexuality, improve their ability to educate about and promote sexual health and develop skills to increase their comfort level in discussing human sexuality” (2021-2022) Georgia Southern University Undergraduate and Graduate Online Course Catalog). This is NOT a personal Human Sexuality course in the traditional sense. PSYC 3237: The Psychology of Human Sexuality would be a better fit, if that type …

Envh 7234 – Environmental Toxicology, Evans Afriyie-Gyawu

College of Public Health: Faculty Syllabi (2014-2021)

This course introduces students to concepts associated with the lethal and sub-lethal effects of environmental and occupational stressors on humans and other living organisms.

Enhanced Detection Of Desmoplasia By Targeted Delivery Of Iron Oxide Nanoparticles To The Tumour-Specific Extracellular Matrix, Meenu Chopra, Jiansha Wu, Yen Ling Yeow, Louise Winteringham, Tristan D. Clemons, Martin Saunders, Venkata Ramana Kotamraju, Ruth Ganss, Kirk W. Feindel, Juliana Hamzah

Faculty Publications

Diagnostic imaging of aggressive cancer with a high stroma content may benefit from the use of imaging contrast agents targeted with peptides that have high binding affinity to the extracellular matrix (ECM). In this study, we report the use of superparamagnetic iron-oxide nanoparticles (IO-NP) conjugated to a nonapeptide, CSGRRSSKC (CSG), which specifically binds to the laminin-nidogen-1 complex in tumours. We show that CSG-IO-NP accumulate in tumours, predominantly in the tumour ECM, following intravenous injection into a murine model of pancreatic neuroendocrine tumour (PNET). In contrast, a control untargeted IO-NP consistently show poor tumour uptake, and IO-NP conjugated to a pentapeptide. …

Near-Term Problems In Meeting World Food Demands At Regional Levels: A Special Issue Overview, Thandiwe Nleya, Sharon A. Clay

Agronomy, Horticulture and Plant Science Faculty Publications

Growing food, feed, and fiber in a manner sustainable for future generations is the starting point for improved food security. As the world population continues to grow, it is imperative to improve many aspects of agronomic production systems to better suit local conditions. This special issue of Agronomy Journal examines what agronomists see as today's or near future problems that are currently looming for different regions of the world. Authors from Africa, Asia, and South and North America were invited to write forum papers for this special issue. Some of the current agronomic practices and policies are unsustainable for diverse …

The Willingness And Ability Of First Responders To Report For Duty During Disasters: A Case Study Of Local Law Enforcement Officers, William Peak

Dissertations

Role abandonment of employees is a vulnerability of first responder organizations that can be exposed when disasters occur. Organizational vulnerabilities created by role abandonment of first responders can be reduced by understanding the willingness and ability of employees to report for duty during disasters. To gain a better understanding of law enforcement organizational vulnerability to disasters, this study utilizes an online survey disseminated to police officers (n = 314) working for a police department along the Gulf Coast to determine their willingness and ability to report for duty and examines the barriers and facilitators impacting their decision to report …

Προετοιμάζοντας Τις Κατώτερες Βαθμίδες Καθηγητών Και Τους Νέους Διδάσκοντες: Έναυσμα Για Διδασκαλία Και Μάθηση, Russell Wartalski, Noreen Powers, Effie Kritikos

Literacy, Leadership, and Development Faculty Publications

Όλο το προσωπικό των κολλεγίων και των πανεπιστημίων αναζητά τρόπους για να βελτιώσει τις πρακτικές διδασκαλίας του. Ωστόσο, οι κατώτερες βαθμίδες καθηγητών και οι νέοι διδάσκοντες στην τριτοβάθμια εκπαίδευση επιδεικνύουν μεγαλύτερο άγχος στην προετοιμασία και την προσαρμογή στους νέους ρόλους διδασκαλίας τους σε σχέση με τους πιο έμπειρους καθηγητές. Το άρθρο αυτό παρέχει σ’ αυτούς τους διδάσκοντες μια βάση για διάφορα πλαίσια μάθησης και δώδεκα καθιερωμένες τεχνικές διδασκαλίας που μπορούν να χρησιμοποιηθούν για τη συμμετοχή φοιτητών όλων των ηλικιών και ακαδημαϊκών επιπέδων σε παραδοσιακά, διαδικτυακά, και υβριδικά περιβάλλοντα μάθησης.

The Role Of Hostile And Benevolent Sexism On Women's Career Aspirations And Self-Doubt In Masculine And Feminine Majors, Mary Tait

Master's Theses (2009 -)

Women experience hostile sexism and benevolent sexism in various aspects of their lives and the effects of these experiences have been shown to greatly affect their performance in career-related domains. Researchers have posited that this reduction in performance is related to self-doubt (Dardenne et al., 2007; Kuchynka et al., 2018) which can affect women’s careers long-term. However, the effects of self-doubt on women’s careers may vary depending on the stereotyped context of the environment. The current study examined if the relationship between experiences with sexism and career aspirations is mediated by self-doubt. Further, it was examined if the relationships changed …

Study Of Extensions To The Linear Sampling Method For Electromagnetic Inverse Scattering, Yeasmin Sultana

Master's Theses (2009 -)

The linear sampling method (LSM) is a simple and effective qualitative method to reconstruct the support of unknown object by solving inverse scattering problem. The solution is done based on the field radiated by the elementary source located in a set of test points. In this thesis, the LSM formulation, limitations of standard LSM and extensions of LSM are discussed. Standard LSM can reconstruct simply connected objects, but it fails in case of concave or not simply connected objects. However, it can reconstruct the convex hull for such objects. Some extensions to LSM have been proposed to avoid these limitations. …

Deep Learning Approach For Dynamic Sampling For High-Throughput Nano-Desi Msi, David Helminiak

Master's Theses (2009 -)

Mass Spectrometry Imaging (MSI) extracts molecular mass data to form visualizations of molecular spatial distributions. The involved scanning procedure is conducted by moving a probe across and around a rectilinear grid, as in the case of nanoscale Desorption Electro-Spray Ionization (nano-DESI) MSI, where singular measurements can take up to ~5 seconds to acquire high-resolution (better than 10 μm) results. This temporal expense creates a high inefficiency in sample processing and throughput. For example, in a high-resolution nano-DESI study, a single mouse uterine tissue section (2.5 mm by 1.7 mm) had an acquisition time of ~4 hours to acquire 104,400 pixels. …

Friends And Family Matter Most: A Trend Analysis Of Increasing E-Cigarette Use Among Irish Teenagers And Sociodemographic, Personal, Peer And Familial Associations, Joan Hanafin, Salome Sunday, Luke Clancy

Articles

Background

E-cigarette ever-use and current-use among teenagers has increased worldwide, including in Ireland.

Methods

We use data from two Irish waves (2015, 2019) of the European School Survey Project on Alcohol and other Drugs (ESPAD) to investigate gender and teenage e-cigarette use (n = 3421 16-year-olds). Using chi-square analyses, we report changes in e-cigarette ever-use, current-use, and associated variables. Using multivariable logistic regression, we analyse the increase in e-cigarette use and socio-demographic, personal, peer and familial associations, focusing on gender differences.

Results

E-cigarette ever-use increased from 23% in 2015 to 37% in 2019, and current-use from 10 to …