Digital Commons Network^™

Cardiac Hdac3 Disruption Contributes To Hdac Inhibitor-Induced Qt Prolongation, Jiao Lu, Christopher Ward, Sichong Qian, Lilei Zhang, Jiang Chang, Zheng Sun

Faculty, Staff and Students Publications

Histone deacetylase (HDAC) inhibitors are approved for cancer treatment and are being investigated for a wide range of other diseases. Despite their therapeutic promise, clinical studies have reported cardiac side effects, particularly electrocardiogram (EKG) abnormalities, with QT interval prolongation being one of the most consistently reported findings. The mechanisms underlying these cardiac effects remain unclear. In this study, we investigated the role of HDAC3 in cardiac electrophysiology. We found that postnatal depletion of cardiac HDAC3 in mice caused QT interval prolongation, recapitulating the EKG abnormalities reported with HDAC inhibitor use. Adult-onset inducible depletion of cardiac HDAC3 induced additional EKG abnormalities, …

Be Prepared For Your Nurse Practitioner Clinical Readiness Exam, Elizabeth Heavey, Renee Biedlingmaier, Colleen Burgoyne, Carnel C. Jackson

Milne Open Textbooks

This text contains case studies and review questions for nurse practitioner students; focusing on the 3Ps of nurse practitioner education (Pharmacology, Pathophysiology, and Physical (Health) Assessment) to help NP students prepare for their clinical courses and pass their clinical readiness exam.  It includes cases commonly seen in entry-level NP practice.  In addition to the three individual sections of the text that focus on cases applying content from each of the distinct courses (Pathophysiology, Pharmacology, and Physical Assessment), we included summative case studies at the end of the book that connect all three areas in a single case. Because these three …

A Novel Machine-Learning Based Method For Resolving Secondary Structure Topology In Medium-Resolution Cryo-Em Density Maps, Bahareh Behkamal, Mohammad Parsa Etemadheravi, Ali Mahmoodjanloo, Amin Mansoori, Mahmoud Naghibzadeh, Kamal Al Nasr, Mohammad Reza Saberi

Computer Science Faculty Research

Medium-resolution cryo-electron microscopy (cryo-EM) density maps preserve substantial information about protein secondary-structure organization; however, accurately recovering the topology and connectivity of α-helices and β-strands remains challenging due to noise, structural heterogeneity, and the intrinsic resolution limitations that obscure residue-level detail. Topology determination is a key intermediate step toward building atomic protein models from medium-resolution cryo-EM density maps. It requires identifying the correct correspondence and orientation between secondary-structure elements (SSEs), i.e., α-helices and β-strands, predicted from the amino-acid sequence and those detected in the three dimensional (3D) density map. Despite significant advances in cryo-EM reconstruction and molecular modelling, this correspondence problem …

Quality Care For Neurodivergent Youth, Emily V. Bogaev

Dissertations, 2020-current

Neurodivergent youth are becoming increasingly present in counseling settings, yet many counseling approaches have historically been shaped by deficit-oriented frameworks that conceptualize neurodivergence as something to be corrected. These perspectives may overlook the lived experiences and strengths of neurodivergent individuals. The purpose of this dissertation was to examine neurodivergence in counseling through three complementary manuscripts addressing conceptual foundations, youth perspectives, and counselor preparation. The first manuscript is a conceptual article that explores neurodivergent-affirming counseling and contrasts affirming frameworks with traditional deficit-based approaches. The second manuscript utilized a qualitative narrative inquiry design to explore neurodivergent youths’ perceptions of neurodivergence and the …

Exploring Spike-Dependent And Ace2-Independent Sars-Cov-2 Interactions With Salivary Epithelial Cells In The Absence Of Ace2, Caitlynn M L Barrows, Thaise C Geremias, Simon Young, Mary C Farach-Carson

Faculty, Staff and Student Publications

Salivary gland infection by SARS-CoV-2 requires viral entry via routes and mechanisms that remain unresolved. This study examined the expression of the angiotensin-converting enzyme 2 (ACE2) receptor in salivary tissues and basal cell-derived human salivary progenitor cells (hS/PCs), an unstudied potential entry point for SARS-CoV-2. Multiple detection modalities, including immunocytochemistry, Western blotting, flow cytometry and RT-PCR, demonstrated a consistent lack of ACE2 protein and transcript in both tissue specimens and primary salivary epithelial cells. Antigen retrieval at pH 9 was determined to be optimal for immunodetection protocols, yet ACE2 remained undetectable. Small intestine tissue served as a positive control, confirming …

Future-Oriented Science Education: A Delphi Study Of Policymakers’ Views From Four European Countries, Sibel Erduran, Jessica Chan, Olga Ioannidou

School of Law, Humanities and Social Sciences

Future-oriented skills have become increasingly important in science education. These skills include critical thinking, problem solving and managing complexity. While policymaking has a direct bearing on the what and the how of a future-oriented perspective in science education, previous research focused on a narrow group of stakeholders such as teachers and students. Little is known about what policymakers perceive as significant future-oriented skills to be included in the science curriculum. By policymakers we mean government officials, legislators, educational administrators, and other influential figures who are key decision-makers in the educational eco-system. The exploratory empirical study reported in the paper employed …

Elementary Students' Science Attitudes And Teachers' Implementation Of The Ngss Science Practices: A Mixed Methods Study, Michelle Laborn

Dissertations

It has been recorded in the literature that student science interest drops as students enter and transition to middle and high school. This dissertation takes up the areas of student science interest and the teaching of the science practices in the context of elementary education. This study seeks to understand student science interest in elementary students in the years before entering middle school where a drop of interest is frequently reported. It is hypothesized that an increased use or implementation of the NGSS science practices by classroom teachers would generate higher science interest in elementary students. In a framework of …

Pedagogical Possibilities Toward Positive Embodiment: Applying The Developmental Theory Of Embodiment To Educational Contexts, Elena Buis

Dissertations

Young adolescents, particularly girls, often experience uncomfortable and negative relationships with their bodies, contributing to negative physical, mental, and emotional outcomes. Although educators have implemented interventions to address this issue, those grounded in positive embodiment remain underexplored. Specifically, the Developmental Theory of Embodiment (DTE), a prominent framework in eating disorder and body image research, has not been integrated into educational research or practice. This dissertation explores the integration of DTE into educational theory, practice, and pedagogy across three complementary articles and examines the teaching and learning of Be Body Positive (BBP), a positive embodiment intervention, with a fifth grade Girl …

Care As Method: Sound, Duration, Relation In Contemporary Art Practice, Violet L. White

MFA in Visual Art

Abstract Care as Method: Sound, Duration, and Multispecies Relation in Contemporary Art Practice

This thesis proposes care as a method of artmaking, not a subject, theme, or aesthetic position, but the actual structural logic through which a body of work is built, sustained, and understood. Working at the intersection of ecological art practice and relational aesthetics, it asks what happens when the encounter at the center of the work is not between two people but between species, infrastructures, and histories of use and what obligations that encounter generates.

The argument is developed through six interconnected works: installations, sound compositions, sculptures, …

Louisiana State University Health Sciences Center - 2026 - 153rd Commencement, Office Of The Registrar, Lsu Health Sciences Center-No

Graduation & Commencement Programs

The program for the 153rd Commencement of LSU Health Sciences Center - New Orleans held May 14, 2026.

Environmental Dna (Edna) Assessment Of Fish And Decapod Diversity And Their Association With Cetacean Distribution In Matang Coastal Waters, Perak, Lim Chuan Hui

Student Works (2020-2029)

The estuarine and coastal regions of Matang, Perak, Peninsular Malaysia, are vital fishing grounds and recognised biodiversity hotspots, but are increasingly exposed to human activities. Understanding the biodiversity of marine fish and decapods is crucial for effective conservation efforts. Conventional biodiversity monitoring methods face several challenges, including invasiveness, inconsistencies in sampling techniques, reduced taxonomic accuracy, time-consuming processes, high costs, and often only providing approximate estimates. In this study, we evaluated the use of environmental DNA (eDNA) metabarcoding to assess marine fish and decapod diversity in Matang waters and to explore possible associations between fish assemblages and local cetacean occurrence. Water …

Wendy Repovich Oral History Interview, Wendy Repovich, Carter Burson

Eastern Washington University Staff and Faculty Oral Histories

Professor Wendy Repovich taught Exercise Science at Eastern Washington University (EWU) from 1990-2016.

In this interview, Repovich discusses her role as one of EWU's early professors of Exercise Science. Repovich discusses her mentorship of prospective graduate students, the growth of the Exercise Science program, changes to campus during her time there, and the importance of hands-on education in the Exercise Science program.

The transcript has been reviewed by the interviewee and corrections have been made for the purposes of clarity and accuracy. The original recordings have been preserved and are available upon request.

Carter Burson interviewed Wendy Repovich in Spring …

The Impact Of Partner Quality On Female Perception Of Ovulation Cues During Pregnancy, Zoe Michelle Hannabass

Masters Theses, 2020-current

Human ovulation is largely concealed, yet subtle fertility-related cues, including facial and vocal changes, may influence mate selection and intrasexual competition (Thornhill & Gangestad, 2008; Haselton & Gildersleeve, 2016). These cues are thought to “leak” across the menstrual cycle and shape social perception in ways that are not always consciously detected. Pregnancy represents a unique context in which reproductive priorities shift, as women become increasingly dependent on partner resources for maternal and fetal well-being. As a result, traits signaling physical attractiveness, signaling genetic quality, become less important while those signaling partner investment may become more important among pregnant females. This …

How Does Age Affect Our Memory? Semantic Relatedness In Proper Name Recall, Art Beqiraj

Masters Theses, 2020-current

Proper names belong to a distinct class of lexical items that pose challenges for encoding and retrieval across people of all ages. Unlike common nouns, and the exception of nicknames, proper names are arbitrary relative to their referent. Forgetting someone’s name is not only seen as a social faux pas but may be particularly concerning for older adults due to its interpretation as a cognitive decline indicator. Prior research has shown that when names are physically descriptive of their referent (e.g., a giraffe called ‘Lengthy’), they are better learned and recalled; however, the extent to which descriptiveness without a visual …

A Reassessment Of “Tityus” Tenuimanus Banks, 1910, As A Misidentified Leiurus Sp. (Scorpiones: Buthidae), Mohamed Mousaid, Ersen A. Yağmur, Zoe Flores, Alana Rivera, Aziza Lansari, Abdellah Bouazza

Euscorpius

This study re-examines the holotype of “Tityus” tenuimanus Banks, 1910, previously synonymized with Buthus atlantis Pocock, 1889 by Lourenço & Francke (1984). Our results indicate that the specimen is a misidentified representative of Leiurus Ehrenberg, 1828, as it exhibits the diagnostic characters of this genus: the central lateral and posterior median carinae of the carapace fused into a lyre-shaped configuration, and tergites I–II bearing five granular carinae (a character absent in the genus Buthus Leach, 1815). Moreover, the holotype lacks one of the most distinctive characters of the genus Tityus Koch, 1836, namely the presence of a subaculear tubercle. The …

The Dynamics Of Synchrony On Replicating Biological Populations, Montse Torres Garcia, Kevin Mcgoff, Francis Motta, Breschine Cummins, Steve Haase

Biology and Medicine Through Mathematics Conference

No abstract provided.

Computation Models Of The Primary Auditory Cortex, Jonathan Gonzalez Martinez, Quynh-Anh Nguyen

Biology and Medicine Through Mathematics Conference

No abstract provided.

Gap Junction Architecture And Synchronization Clusters In The Thalamic Reticular Nuclei, Alex Norwood

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modeling Serotonin Metabolism Towards A Diagnostic Skin Test For Depression, Joel Greenfield

Biology and Medicine Through Mathematics Conference

No abstract provided.

Dynamical Systems Modeling To Determine The Role Of Crosstalk In Shaping Stat Signaling Profiles, Laura F. Strube, Anamarie Martinez, Neha Cheemalavagu, Karsen Shoger, James Faeder, Rachel Gottschalk

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Stochastic And Spatial Model Of Microtubule Dynamics In Neuronal Dendrites, Meghan Kwon

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mathematical Modeling Of A Coral-Symbiont System To Assess Heat-Induced Bleaching, Anna Zittle, Angela Reynolds, Rebecca Segal, Liza Roger, Nastassja Lewinski

Biology and Medicine Through Mathematics Conference

No abstract provided.

Parameter Sensitivity, Identifiability, And Estimation For A Data-Driven Model Of Malaria, Katharine Gurski, Kathleen Hofman

Biology and Medicine Through Mathematics Conference

No abstract provided.

Ontario High School Teacher Perspectives On Failure: Bridging Policy And Practice, Dan Guadagnolo, Kelly Li, Klea Mosho, Megan Anderson, Nicole Laliberte, Fiona Rawle

Journal of Educational Research and Practice

This study explores teacher perceptions of the role of failure in secondary school education. Our case study analysis, based on 23 interviews in Ontario, Canada, suggests secondary school teachers understand failure as a core element of the learning process. However, teachers do not feel they can easily use failure as a pedagogical tool. Teachers perceive Ontario Ministry of Education guidelines regarding student success to have created an institutional culture within which student failure is administratively burdensome and is framed as external to the learning process. These success narratives in government assessment guidelines have created a situation wherein teachers often feel …

From Beirut To Montreal, En-Camp-Ment-S On The Fringes Of Society, But What Society, Soñar Soñar

Gatherings

This text is a prose that retraces my experience as a researcher and activist in three camps, between April 2024 and July 2024 : the Palestinian refugee camp in Lebanon, Bourj El Barajne, and the pro-Palestine encampments in Montreal, Al-Aqsa and Al-Soumoud. The text is a continuation of writings of different genres, particularly creative, which relate facts and lived experiences around liberation struggles. This writing constitutes “a method of inquiry”, “a way of “knowing” – a method of discovery and analysis. By writing in different ways, we discover new aspects of our topic and our relationship to it” (Richardson 516).

Member Spotlight - Dr. Neil Small, Christopher R. Spagna Dmd

Virginia Dental Journal

No abstract provided.

Making (Heat)Waves: Intermittent Thermal Stress Effects On Beet Armyworm (Spodoptera Exigua) Growth To Eclosion, Shane Dreher, Swayamjit Ray

Research and Creative Works Expo

In this study, we demonstrated how application of heat stress, followed by rapid cooling, affected the rate at which beet armyworm caterpillars gained weight, entered pupation and exited their pupae as moths via eclosion.

Va Dent J April, May And June 2016.Pdf

Virginia Dental Journal

No abstract provided.

Menstrual Monster Or Criminal Lady?: Ella Castle, Biopower, And The Plight Of The Female Kleptomaniac In Late 19th Century America., Grace S. Teske

Madison Historical Review

On October 5, 1896, Ella Castle, a San Franciscan socialite, was arrested in London for shoplifting. In the proceeding months, Castle's trial became a transatlantic sensation, as her initial veneer as a respectable upper-class woman was replaced by the image of an ill and unstable woman suffering from kleptomania. The case of Ella Castle is representative of the larger social and economic processes that developed in the late 19th century that converged together in the diagnosis of kleptomania. One of the main transformations was the development of consumer capitalism which manifested into the new urban institution of the department store. …

Mail To Amp And Ruth

Lloyd Clark Papers

Copy of an article discussing changes at The University of Texas at Arlington, sent to Amp and Ruth Miller.