Digital Commons Network^™

Gradient Preserved And Artificial Neural Network Method For Solving Heat Conduction Equations In Double Layered Structures, Aniruddha Bora

Doctoral Dissertations

Layered structures have appeared in many engineering systems such as biological tissues, micro-electronic devices, thin  lms, thermal coating, metal oxide semiconductors, and DNA origami. In particular, the multi-layered metal thin  lms, gold-coated metal mirrors for example, are often used in high-powered infrared-laser systems to avoid thermal damage at the front surface of a single layer  lm caused by the high-power laser energy. With the development of new materials, functionally graded materials are becoming of more paramount importance than materials having uniform structures. For instance, in semiconductor engineering, structures can be synthesized from di erent polymers, which result in various values …

Carbon Nano Based Materials And Their Composites For Gas Sensing Applications: Review, Mohamed Morsy

Nanotechnology Research Centre

No abstract provided.

The Utah Statesman, November 1, 2021, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Ultrasound Regulated Flexible Protein Materials: Fabrication, Structure And Physical-Biological Properties., Bowen Cai, Hanling Gu, Fang Wang, Kyle Printon, Zhenggui Gu, Xiao Hu

College of Science & Mathematics Departmental Research

Ultrasound can be used in the biomaterial field due to its high efficiency, easy operation, no chemical treatment, repeatability and high level of control. In this work, we demonstrated that ultrasound is able to quickly regulate protein structure at the solution assembly stage to obtain the designed properties of protein-based materials. Silk fibroin proteins dissolved in a formic acid-CaCl solution system were treated in an ultrasound with varying times and powers. By altering these variables, the silks physical properties and structures can be fine-tuned and the results were investigated with Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron …

Pseudo-Science And ‘Fake’ News ‘Inventing’ Epidemics And The Police State, Babette Babich

Articles and Chapters in Academic Book Collections

No abstract provided.

Indigenous-Led Conservation Reading List, Megan Youdelis, Kim Tran, Elizabeth Lunstrum

Environmental Studies Program Faculty Publications and Presentations

This list compiles literature relevant to the bourgeoning Indigenous-led conservation movement, be that through Indigenous Protected and Conserved Areas (IPCAs, Canada), Indigenous and Community Conserved Areas (ICCAs, global), or various other forms of Indigenous-led governance or co-governance mechanisms that elevate Indigenous rights, responsibilities, and legal traditions. The introductory Colonial Conservation section is not exhaustive, but rather provides context for the main import of the collection, which is to highlight the possibilities, successes, and challenges associated with decolonizing conservation through Indigenous-led governance. The list is global in scope but has been shaped by the Indigenous Circle of Experts’ (2018) report, We …

Women's Basketball Media Guide 2021-22, Wofford College. Department Of Athletics

Media Guides

No abstract provided.

Men's Basketball Media Guide 2021-22, Wofford College. Department Of Athletics

Media Guides

No abstract provided.

The Effect Of Increased Recess Time On The Academic Achievement Of Elementary Students, Mark A. Taylor

ATU Theses and Dissertations 2021 - Present

Arkansas lawmakers enacted Act 641 of 2019, which increased recess time during the school day from 30 minutes to 40 minutes per day. Recess is defined as unstructured free play for students outside when possible. Recess is an important part of the school day. Recess improves social skills, time on task, positive attitudes towards school and increasing physical activity. The purpose of this quantitative study was to determine if increasing recess time for third, fourth and fifth grade elementary students had an impact on ACT Aspire tests results. This study was a quantitative study using a series of independent t-tests. …

The R Journal (December 2021) 13(2): Complete Issue, The R Foundation

The R Journal

On behalf of the R Foundation and the Editorial board, I am pleased to present Volume 13 Issue 2 of the R Journal. This is the biggest issue ever!

First, some news from the Editorial board. A big thank you to Mike Kane, who has finished his term. As Editor-in-Chief in 2020, Mike expanded operations to include Associate Editors in the reviewing process. The R Journal now has a team of 20 Associate Editors. This has helped to manage the increasing number of submissions. We welcome new Associate Editors, Przemek Biecek, Chris Brunsdon, Mine Çetinkaya-Rundel, Kieran Healy, Adam Loy, Priyanga …

The Chanticleer, 2021 November, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

Cetacean Acousticwelfare In Wild And Managed-Care Settings: Gaps And Opportunities, Paige E. Stevens, Heather Hill, Jason N. Bruck

Faculty Publications

Cetaceans are potentially at risk of poor welfare due to the animals’ natural reliance on sound and the persistent nature of anthropogenic noise, especially in the wild. Industrial, commercial, and recreational human activity has expanded across the seas, resulting in a propagation of sound with varying frequency characteristics. In many countries, current regulations are based on the potential to induce hearing loss; however, a more nuanced approach is needed when shaping regulations, due to other non-hearing loss effects including activation of the stress response, acoustic masking, frequency shifts, alterations in behavior, and decreased foraging. Cetaceans in managedcare settings share the …

On The Relationship Between Pain Variability And Relief In Randomized Clinical Trials, Siddharth Tiwari '22

Student Publications & Research

Previous research suggests greater baseline variability is associated with greater pain relief in those who receive a placebo. However, studies that evidence this association do not control for confounding effects (natural history and regression-to-the-mean); for this reason, we analyzed data from two randomized clinical trials (Placebo I and Placebo II, N = 134) while adjusting for confounding effects via a no-treatment group. Results agree between the two placebo groups: both placebo groups showed a negligible correlation between baseline variability and adjusted response (r sp (CI 95% ) = 0.13 (−0.09, 0.37) and 0.01 (−0.15, 0.20) for Placebo I and II, …

U2af1 Is A Haplo-Essential Gene Required For Hematopoietic Cancer Cell Survival In Mice, Brian A Wadugu, Sridhar Nonavinkere Srivatsan, Amanda Heard, Michael O Alberti, Matthew Ndonwi, Jie Liu, Sarah Grieb, Joseph Bradley, Jin Shao, Tanzir Ahmed, Cara L Shirai, Ajay Khanna, Christopher A Miller, Matthew J Walter, Et Al

Open Access Publications

Somatic mutations in the spliceosome gene U2AF1 are common in patients with myelodysplastic syndromes. U2AF1 mutations that code for the most common amino acid substitutions are always heterozygous, and the retained WT allele is expressed, suggesting that mutant hematopoietic cells may require the residual WT allele to be viable. We show that hematopoiesis and RNA splicing in U2af1 heterozygous knockout mice were similar to those in control mice, but that deletion of the WT allele in U2AF1(S34F) heterozygous mutant-expressing hematopoietic cells (i.e., hemizygous mutant) was lethal. These results confirm that U2AF1 mutant hematopoietic cells are dependent on the expression of …

Lab-On-A-Chip Thermoelectric And Solid-Phase Immunodetection Of Biochemical Analytes And Extracellular Vesicles: Experimental And Computational Analysis, Saif Mohammad Ishraq Bari

Doctoral Dissertations

Microfluidics is the technology of controlling and manipulating fluids at the microscale. Microfluidic platforms provide precise fluidic control coupled with low sample volume and an increase in the speed of biochemical reactions. Lab-on-a-chip platforms are used for detection and quantification of biochemical analytes, capture, and characterization of various proteins, sensitive analysis of cytokines, and isolation and detection of extracellular vesicles (EVs).

This study focuses on the development of microfluidic and solid-phase capture pin platforms for the detection of cytokines, extracellular vesicles, and cell co-culture. The fabrication processes of the devices, experimental workflows, numerical analysis to identify optimal design parameters, and …

Oxidative Phosphorylation Is A Metabolic Vulnerability In Chemotherapy-Resistant Triple-Negative Breast Cance, Kurt W. Evans, Erkan Yuca, Stephen S. Scott, Ming Zhao, Natalia Paez Arango, Christian X. Cruz Pico, Turcin Saridogan, Maryam Shariati, Caleb Class, Christopher A. Bristow, Christopher P. Vellano, Xiaofeng Zheng, Ana Maria Gonzalez-Angulo, Xiaoping Su, Coya Tapia, Ken Chen, Argun Akcakanat, Bora Lim, Debu Tripathy, Timothy A. Yap, Maria Emilia Di Francesco, Giulio F. Draetta, Philip Jones, Heffernan P. Heffernan, Joseph R. Marszalek, Funda Meric-Bernstam

Scholarship and Professional Work – COPHS

Oxidative phosphorylation (OXPHOS) is an active metabolic pathway in many cancers. RNA from pretreatment biopsies from patients with triple-negative breast cancer (TNBC) who received neoadjuvant chemotherapy demonstrated that the top canonical pathway associated with worse outcome was higher expression of OXPHOS signature. IACS-10759, a novel inhibitor of OXPHOS, stabilized growth in multiple TNBC patient-derived xenografts (PDX). On gene expression profiling, all of the sensitive models displayed a basal-like 1 TNBC subtype. Expression of mitochondrial genes was significantly higher in sensitive PDXs. An in vivo functional genomics screen to identify synthetic lethal targets in tumors treated with IACS-10759 found several potential …

The Primarily Undergraduate Nanomaterials Cooperative: A New Model For Supporting Collaborative Research At Small Institutions On A National Scale, Steven M. Huges, Mark P. Hendricks, Katherine M. Mullaugh, Mary E. Anderson, Anne K. Bently, Justin G. Clar, Clyde A. Daly Jr., Mark D. Ellison, Z. Vivian Feng, Natalia I. Gonzalex-Pech, Leslie S. Hamachi, Christine L. Heinecke, Joseph D. Keene, Adam M. Maley, Andrea M. Munro, Peter N. Njoki, Jacob H. Olshansky, Katherine E. Plass, Kathryn R. Riley, Matthew D. Sonntag, Sarah K. St. Angelo, Lucas B. Thompson, Emily J. Tollefson, Lauren E. Toote, Korin E. Wheeler

Chemistry Faculty Publications

The Primarily Undergraduate Nanomaterials Cooperative (PUNC) is an organization for research-active faculty studying nanomaterials at Primarily Undergraduate Institutions (PUIs), where undergraduate teaching and research go hand-in-hand. In this perspective, we outline the differences in maintaining an active research group at a PUI compared to an R1 institution. We also discuss the work of PUNC, which focuses on community building, instrument sharing, and facilitating new collaborations. Currently consisting of 37 members from across the United States, PUNC has created an online community consisting of its Web site (nanocooperative.org), a weekly online summer group meeting program for faculty and students, …

Contact Normalization And The Role Of Maackia Amurensis Seed Lectin As A Novel Chemotherapeutic And Antiviral Agent, Stephanie A. Sheehan

Graduate School of Biomedical Sciences Theses and Dissertations

Cells communicate with each other to coordinate tissue function and homeostasis. Diseases including cancer, arthritis, and acute respiratory disease syndrome (ARDS) require a breakdown in this intercellular communication. For example, cancer progression is suppressed by junctional communication between nontransformed and transformed cells. This process is called contact normalization. Junctional communication must be disrupted to enable transformed cells to grow into malignancies. However, the junctions and mechanisms by which nontransformed cells normalize cell behavior have not been clearly defined. My project aimed to identify junctions and elucidate mechanisms underlying contact normalization. We discovered that cadherins, specifically N-cadherin, form junctions that enable …

A Prospective Examination Of Sex Differences In Posttraumatic Autonomic Functioning, Antonia Seligowski, Elizabeth Steuber, Rebecca Hinrichs, Mariam Reda, Charis Wiltshire, Cassandra Wanna, Sterling Winters, Karlye Phillips, Stacey House, Francesca Beaudoin, Xinming An, Jennifer Stevens, Donglin Zeng, Thomas Neylan, Gari Clifford, Sarah Linnstaedt, Laura Germine, Kenneth Bollen, Guia Guffanti, Scott Rauch, John Haran, Alan Storrow, Brittany Punches, Michael Kurz, Vishnu Murty, Meghan Mcgrath, Lauren Hudak, Jose Pascual, Mark Seamon, Elizabeth Datner, Anna Marie Chang, Claire Pearson, David Peak, Roland Merchant, Robert Domeier, Niels Rathlev, Brian O'Neil, Leon Sanchez, Steven Bruce, Mark Miller, Robert Pietrzak, Jutta Joormann, Deanna Barch, Diego Pizzagalli, John Sheridan, Beatriz Luna, Steven Harte, James Elliott, Karestan Koenen, Ronald Kessler, Samuel Mclean, Kerry Ressler, Tanja Jovanovic

Psychology Faculty Works

BackgroundCross-sectional studies have found that individuals with posttraumatic stress disorder (PTSD) exhibit deficits in autonomic functioning. While PTSD rates are twice as high in women compared to men, sex differences in autonomic functioning are relatively unknown among trauma-exposed populations. The current study used a prospective design to examine sex differences in posttraumatic autonomic functioning.Methods192 participants were recruited from emergency departments following trauma exposure (Mean age = 35.88, 68.2% female). Skin conductance was measured in the emergency department; fear conditioning was completed two weeks later and included measures of blood pressure (BP), heart rate (HR), and high frequency heart rate variability …

Vulnerability To Substance Abuse: A Consideration Of Allostatic Loading Factors, Laura O'Dell

Departmental Papers (Psych)

No abstract provided.

Proteinase 3 Contributes To Endothelial Dysfunction In An Experimental Model Of Sepsis, Eric K. Patterson, Carolina Gillio-Meina, Claudio M. Martin, Douglas D. Fraser, Logan R. Van Nynatten, Marat Slessarev, Gediminas Cepinskas

Paediatrics Publications

In sepsis-induced inflammation, polymorphonuclear neutrophils (PMNs) contribute to vascular dysfunction. The serine proteases proteinase 3 (PR3) and human leukocyte elastase (HLE) are abundant in PMNs and are released upon degranulation. While HLE’s role in inflammation-induced endothelial dysfunction is well studied, PR3’s role is largely uninvestigated. We hypothesized that PR3, similarly to HLE, contributes to vascular barrier dysfunction in sepsis. Plasma PR3 and HLE concentrations and their leukocyte mRNA levels were measured by ELISA and qPCR, respectively, in sepsis patients and controls. Exogenous PR3 or HLE was applied to human umbilical vein endothelial cells (HUVECs) and HUVEC dysfunction was assessed by …

Wrack Lines Volume 21, Number 2, Fall/Winter 2021-22, Nancy C. Balcom, Judy Benson, Syma A. Ebbin, Kira Goldenberg, Judy Preston, Howard "Mickey" Weiss

Wrack Lines

"Discovery, Rediscovery and Rebirth: new eyes, new understanding of familiar places" is the theme for the Fall-Winter 2021-22 issue. The main article package consists of five stories about the lands and waters that will comprise the Connecticut National Estuarine Research Reserve (CT NERR). These are: overview and introduction; Great Island; lower Thames River; Bluff Point State Park; and Haley Farm State Park. Other articles include one on research into the cause of invasive Cladophora seaweed dominating Little Narragansett Bay; and another on the transformation of the Yale Peabody Museum of Natural History.

Relating Multivariate Shapes To Genescapes Using Phenotype-Biological Process Associations For Craniofacial Shape, Jose D. Aponte, David C. Katz, Daniela M. Roth, Marta Vidal-García, Wei Liu, Fernando Andrade, Charles C. Roseman, Steven A. Murray, James Cheverud, Daniel Graf, Ralph S. Marcucio, Benedikt Hallgrímsson

Biology: Faculty Publications and Other Works

Realistic mappings of genes to morphology are inherently multivariate on both sides of the equation. The importance of coordinated gene effects on morphological phenotypes is clear from the intertwining of gene actions in signaling pathways, gene regulatory networks, and developmental processes underlying the development of shape and size. Yet, current approaches tend to focus on identifying and localizing the effects of individual genes and rarely leverage the information content of high-dimensional phenotypes. Here, we explicitly model the joint effects of biologically coherent collections of genes on a multivariate trait – craniofacial shape – in a sample of n = 1145 …

Three Decades Of The Human Genome Organization., Charles Lee, Stylianos E Antonarakis, Ada Hamosh, John Burn

Faculty Research 2021

The Human Genome Organization (HUGO) was initially established in 1988 to help integrate international scientific genomic activity and to accelerate the diffusion of knowledge from the efforts of the human genome project. Its founding President was Victor McKusick. During the late 1980s and 1990s, HUGO organized lively gene mapping meetings to accurately place genes on the genome as chromosomes were being sequenced. With the completion of the Human Genome Project, HUGO went through some transitions and self-reflection. In 2020, HUGO (which hosts a large annual scientific meeting and comprises the renowned HUGO Gene Nomenclature Committee [HGNC], responsible for naming genes, …

38th Annual Reception Bibliography, 2020-2021, Leonard H. Axe Library

Bibliographies

Since 1984, Leonard H. Axe Library at Pittsburg State University has honored book authors and other creators for their outstanding scholarship and contributions to their fields.

Engaging Students In Equitable Hands-On Assessments, Sowmya Anjur

Faculty Publications & Research

I have successfully replaced written assessments with more equitable and innovative hands-on projects such as heart modeling and creating graphic novels in my classroom, which help improve student engagement and stimulate their passion for learning.

The Enigma Of Clinical Next Generation Sequencing (Ngs) Based Genetic Testing Variant Annotation Tools: A Performance Evaluation Study, Sachleen Tuteja '23

Student Publications & Research

As the scientific community continues to discover novel genetic variants associated with human constitutional disorders, there is a growing need for a standardized approach for reporting of genetic variants, as accurate variant identification is crucial for effective diagnosis and treatment. Robust identification and annotation of genetic variants relevant for human germline disorders is foundational for clinical Next Generation Sequencing (NGS) assays. Using a manually curated set of 296 variants, generated by targeted gene panel sequencing using the ~4700 gene medical exome panel on 105 patients, we evaluated the performance of two variant annotation tools (Variant Effect Predictor and Alamut Batch) …

Settler Kitsch The Legacies Of Puritanism In America, Jonathan Beecher Field

Publications

No abstract provided.

Hadron, Eunice Kim '22, Lily Song '22

Hadron Magazine

• Pg 4 : Anxiety and Evolution
• Pg 5 : Prescription Fires
• Pg 7 : The New Uber?
• Pg 8 : Changing Society
• Pg 10 : The Rare and Elusive Spirit Bear
• Pg 12 : How Lasers Could Solve the World Energy Crisis
• Pg 14 : The Physics of Water Wakes
• Pg 17 : Schwarzschild Cosmology and Black Hole-ception!
• Pg 19 : The Future of Space Tourism
• Pg 20 : Not Just Bitcoin
• Pg 21 : The Evolving Medical Power of Psychedelics
• Pg 24 : Usage of Hydrogels in Wound Healing
• Pg 26 : New COVID-19 Variant Spreading Across South America …

The Sulfur Microbial Diet Is Associated With Increased Risk Of Early-Onset Colorectal Cancer Precursors, Long H. Nguyen, Yin Cao, Jinhee Hur, Raaj S. Mehta, Daniel R. Sikavi, Yiqing Wang, Wenjie Ma, Kana Wu, Mingyang Song, Edward L. Giovannucci, Eric B. Rimm, Walter C. Willett, Wendy S. Garrett, Jacques Izard, Curtis Huttenhower, Andrew T. Chan

Food for Health: Publications

Background and aims: Diet may contribute to the increasing incidence of colorectal cancer (CRC) before age 50 (early-onset CRC). Microbial metabolism of dietary sulfur produces hydrogen sulfide (H₂S), a gastrointestinal carcinogen that cannot be easily measured at scale. As a result, evidence supporting its role in early neoplasia is lacking.

Methods: We evaluated long-term adherence to the sulfur microbial diet, a dietary index defined a priori based on increased abundance of 43 bacterial species involved with sulfur metabolism, with risk of CRC precursors among 59,013 individuals who underwent lower endoscopy in the Nurses’ Health Study II …