Digital Commons Network^™

Comparison Of Circulating Tumour Dna And Extracellular Vesicle Dna By Low-Pass Whole-Genome Sequencing Reveals Molecular Drivers Of Disease In A Breast Cancer Patient, Olivia Ruhen, Bob Mirzai, Michael E. Clark, Bella Nguyen, Carlos Salomon, Wendy Erber, Katie Meehan

Research outputs 2014 to 2021

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. There is increasing recognition of circulating tumour DNA (ctDNA) as a non-invasive alternative to tumour tissue for the molecular characterisation and monitoring of disease. Recent evidence suggests that cancer-associated changes can also be detected in the DNA contained within extracellular vesicles (EVs). As yet, there has been limited investigation into the relationship between EV DNA and ctDNA, and no studies have examined the EV DNA of breast cancer patients. The aim of this study was to use low-pass whole-genome sequencing to identify copy number variants (CNVs) in serial samples of both …

Titanium Nitride Thin Film Based Low‐Redox‐Interference Potentiometric Ph Sensing Electrodes, Shimrith Paul Shylendra, Wade Lonsdale, Magdalena Wajrak, Mohammad Nur‐E‐Alam, Kamal Alameh

Research outputs 2014 to 2021

© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

In this work, a solid‐state potentiometric pH sensor is designed by incorporating a thin film of Radio Frequency Magnetron Sputtered (RFMS) Titanium Nitride (TiN) working electrode and a commercial Ag|AgCl|KCl double junction reference electrode. The sensor shows a linear pH slope of −59.1 mV/pH, R2 = 0.9997, a hysteresis as low as 1.2 mV, and drift below 3.9 mV/hr. In addition, the redox interference performance of TiN electrodes is compared with that of Iridium Oxide (IrO2) counterparts. Experimental results show −32mV potential shift (E0 value) in 1 mM ascorbic acid (reducing …

A Temporal Record Of Microplastic Pollution In Mediterranean Seagrass Soils, Martin Dahl, Sanne Bergman, Mats Björk, Elena Diaz-Almela, Maria Granberg, Martin Gullström, Carmen Leiva-Dueñas, Kerstin Magnusson, Candela Marco-Méndez, Nerea Piñeiro-Juncal, Miguel Ángel Mateo

Research outputs 2014 to 2021

© 2021 Elsevier Ltd Plastic pollution is emerging as a potential threat to the marine environment. In the current study, we selected seagrass meadows, known to efficiently trap organic and inorganic particles, to investigate the concentrations and dynamics of microplastics in their soil. We assessed microplastic contamination and accumulation in 210Pb dated soil cores collected in Posidonia oceanica meadows at three locations along the Spanish Mediterranean coast, with two sites located in the Almería region (Agua Amarga and Roquetas) and one at Cabrera Island (Santa Maria). Almería is known for its intense agricultural industry with 30 000 ha of plastic-covered …

Protein Extraction Protocols For Optimal Proteome Measurement And Arginine Kinase Quantitation From Cricket Acheta Domesticus For Food Safety Assessment, Utpal Bose, James A. Broadbent, Angéla Juhász, Shaymaviswanathan Karnaneedi, Elecia B. Johnston, Sally Stockwell, Keren Byrne, Vachiranee Limviphuvadh, Sebastian Maurer-Stroh, Andreas L. Lopata, Michelle L. Colgrave

Research outputs 2014 to 2021

© 2021 Elsevier Ltd Insects have been consumed by people for millennia and have recently been proposed as a complementary, sustainable source of protein to feed the world's growing population. Insects and crustaceans both belong to the arthropod family. Crustacean (shellfish) allergies are common and potentially severe; hence, the cross-reactivity of the immune system with insect proteins is a potential health concern. Herein, LC-MS/MS was used to explore the proteome of whole, roasted whole and roasted powdered cricket products. Eight protein extraction protocols were compared using the total number of protein and distinct peptide identifications. Within these data, 20 putative …

Numerical Assessment Of The Overall Heat Transfer And Pressure Drop Performances Of An Aqueous Ammonia Base-Nanofluids In Rectangular Microchannel Heat Sinks, Ahmed Mohammed Adham, Hussein A. Mohammed

Research outputs 2014 to 2021

In this paper, the thermal and hydrodynamic performances of an aqueous ammonia base-nanofluid (Al2O3-NH3(aqu)) cooled in a rectangular microchannel heat sink was numerically investigated. The range of Reynolds number used in the investigation were between 140-1400. In order to assess the performance of the system during the employment of the proposed nanofluid, H2O and Al2O3-H2O were also tested and their performances were compared to Al2O3-NH3(aqu) performance in terms of thermal resistance and pressure drop. Results from the simulation showed that the proposed nanofluid outperformed pure water and slightly higher than Al2O3-H2O in terms of thermal resistance (for Re = 1400, …

Longitudinal Trajectories In Cortical Thickness And Volume Atrophy: Superior Cognitive Performance Does Not Protect Against Brain Atrophy In Older Adults, Samantha Gardener, Michael Weinborn, Hamid R. Sohrabi, James Doecke, Pierrick Bourgeat, Stephanie R. Rainey-Smith, Kai-Kai Shen, Jurgen Fripp, Kevin Taddei, Paul Maruff, Olivier Salvado, Greg Savage, David Ames, Colin L. Masters, Christopher C. Rowe, Ralph Martins, Aibl Research Group

Research outputs 2014 to 2021

Background:

Previous research has identified a small subgroup of older adults that maintain a high level of cognitive functioning well into advanced age. Investigation of those with superior cognitive performance (SCP) for their age is important, as age-related decline has previously been thought to be inevitable.

Objective:

Preservation of cortical thickness and volume was evaluated in 76 older adults with SCP and 100 typical older adults (TOAs) assessed up to five times over six years.

Methods:

Regions of interest (ROIs) found to have been associated with super-aging status (a construct similar to SCP status) in previous literature were investigated, followed …

Contact, Moral Foundations Or Knowledge? What Predicts Attitudes Towards Women Who Undergo Ivf, Alicja Malina, Marta Roczniewska, Julie Ann Pooley

Research outputs 2014 to 2021

Background: The willingness to try in vitro fertilization (IVF) as an infertility treatment, as well as its psychosocial consequences for couples, may be influenced by how they perceive the attitudes of general public towards this procedure. The focus of the current study was to identify predictors of attitudes towards mothers who underwent IVF to conceive a child. Three predictors were derived from attitude components: contact with someone who had undergone IVF (behavior), moral foundations (emotions), and the level of knowledge (cognition) about IVF. Method: In total, 817 participants (118 male and 692 female, 7 unreported) from Poland took part in …

Viral-Mediated Microbe Mortality Modulated By Ocean Acidification And Eutrophication: Consequences For The Carbon Fluxes Through The Microbial Food Web, Andrea Malits, Julia A. Boras, Vanessa Balagué, Eva Calvo, Josep M. Gasol, Cèlia Marrasé, Carles Pelejero, Jarone Pinhassi, Maria Montserrat Sala, Dolors Vaqué

Research outputs 2014 to 2021

Anthropogenic carbon emissions are causing changes in seawater carbonate chemistry including a decline in the pH of the oceans. While its aftermath for calcifying microbes has been widely studied, the effect of ocean acidification (OA) on marine viruses and their microbial hosts is controversial, and even more in combination with another anthropogenic stressor, i.e., human-induced nutrient loads. In this study, two mesocosm acidification experiments with Mediterranean waters from different seasons revealed distinct effects of OA on viruses and viral-mediated prokaryotic mortality depending on the trophic state and the successional stage of the plankton community. In the winter bloom situation, low …

Covid-19 Disease Severity And Death In Relation To Vitamin D Status Among Sars-Cov-2-Positive Uae Residents, Habiba Alsafar, William B. Grant, Rafiq Hijazi, Maimunah Uddin, Nawal Alkaabi, Guan Tay, Bassam Mahboub, Fatme Al Anouti

Research outputs 2014 to 2021

Insufficient blood levels of the neurohormone vitamin D are associated with increased risk of COVID-19 severity and mortality. Despite the global rollout of vaccinations and promising preliminary results, the focus remains on additional preventive measures to manage COVID-19. Results conflict on vitamin D’s plausible role in preventing and treating COVID-19. We examined the relation between vitamin D status and COVID-19 severity and mortality among the multiethnic population of the United Arab Emirates. Our observational study used data for 522 participants who tested positive for SARS-CoV-2 at one of the main hospitals in Abu Dhabi and Dubai. Only 464 of those …

Accounting For The Influence Of Temperature And Location When Predicting Seagrass (Halophila Ovalis) Photosynthetic Performance, Nicole E. Said, Kathryn Mcmahon, Paul Lavery

Research outputs 2014 to 2021

We show that the effect of temperature on photosynthesis of a widely distributed and ecological important seagrass species was not consistent among locations, with some evidence of acclimation to the local temperature range. This has important implications for modelling seagrass productivity and the impacts of light reduction on seagrass ecosystems. Reduced light availability is one of the main pressures negatively impacting on seagrass meadows worldwide. Our knowledge of seagrass photosynthetic characteristics is critical to predicting and managing impacts of light reducing activities but suffers from two critical information gaps: first, data is overwhelmingly derived from studies of leaf tissue and …

Dietary Fibre Intervention For Gut Microbiota, Sleep, And Mental Health In Adults With Irritable Bowel Syndrome: A Scoping Review, Ran Yan, Lesley J. Andrew, Evania Marlow, Kanita Kunaratnam, Amanda Devine, Ian C. Dunican, Claus T. Christophersen

Research outputs 2014 to 2021

Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder affecting 4–5% of the global population. This disorder is associated with gut microbiota, diet, sleep, and mental health. This scoping review therefore aims to map existing research that has administrated fibre-related dietary intervention to IBS individuals and reported outcomes on at least two of the three following themes: gut microbiota, sleep, and mental health. Five digital databases were searched to identify and select papers as per the inclusion and exclusion criteria. Five articles were included in the assessment, where none reported on all three themes or the combination of gut …

Learning Deficit In Cognitively Normal Apoe Ε4 Carriers With Low Β-Amyloid, Yen Ying Lim, Jenalle E. Baker, Andrea Mills, Loren Bruns, Christopher Fowler, Jurgen Fripp, Stephanie R. Rainey-Smith, David Ames, Colin L. Masters, Paul Maruff

Research outputs 2014 to 2021

Introduction: In cognitively normal (CN) adults, increased rates of amyloid beta (Aβ) accumulation can be detected in low Aβ (Aβ–) apolipoprotein E (APOE) ε4 carriers. We aimed to determine the effect of ε4 on the ability to benefit from experience (ie, learn) in Aβ–CNs. Methods: Aβ– CNs(n= 333) underwent episodic memory assessments every 18 months for 108 months. A subset (n = 48) completed the Online Repeatable Cognitive Assessment-Language Learning Test (ORCA-LLT) over 6 days. Results: Aβ– ε4 carriers showed significantly lower rates of improvement on episodic memory over 108 months compared to non-carriers (d = 0.3). Rates of learning …

Data Supporting Development And Validation Of Liquid Chromatography Tandem Mass Spectrometry Method For The Quantitative Determination Of Bile Acids In Feces, Armaghan Shafaei, Joanna Rees, Claus T. Christophersen, Amanda Devine, David Broadhurst, Mary C. Boyce

Research outputs 2014 to 2021

Measuring bile acids in feces has an important role in disease prevention, diagnosis, treatment, and can be considered a measure of health status. Therefore, the primary aim was to develop a sensitive, robust, and high throughput liquid chromatography tandem mass spectrometry method with minimal sample preparation for quantitative determination of bile acids in human feces applicable to large cohorts. Due to the chemical diversity of bile acids, their wide concentration range in feces, and the complexity of feces itself, developing a sensitive and selective analytical method for bile acids is challenging. A simple extraction method using methanol suitable for subsequent …

Deep Ocean Metagenomes Provide Insight Into The Metabolic Architecture Of Bathypelagic Microbial Communities, Silvia G. Acinas, Pablo Sánchez, Guillem Salazar, Francisco M. Cornejo-Castillo, Marta Sebastián, Ramiro Logares, Marta Royo-Llonch, Lucas Paoli, Shinichi Sunagawa, Pascal Hingamp, Hiroyuki Ogata, Gipsi Lima-Mendez, Simon Roux, José M. González, Jesús M. Arrieta, Intikhab S. Alam, Allan Kamau, Chris Bowler, Jeroen Raes, Stéphane Pesant, Peer Bork, Susana Agustí, Takashi Gojobori, Dolors Vaqué, Matthew B. Sullivan, Carlos Pedrós-Alió, Ramon Massana, Carlos M. Duarte, Josep M. Gasol

Research outputs 2014 to 2021

The deep sea, the largest ocean’s compartment, drives planetary-scale biogeochemical cycling. Yet, the functional exploration of its microbial communities lags far behind other environments. Here we analyze 58 metagenomes from tropical and subtropical deep oceans to generate the Malaspina Gene Database. Free-living or particle-attached lifestyles drive functional differences in bathypelagic prokaryotic communities, regardless of their biogeography. Ammonia and CO oxidation pathways are enriched in the free-living microbial communities and dissimilatory nitrate reduction to ammonium and H2 oxidation pathways in the particle-attached, while the Calvin Benson-Bassham cycle is the most prevalent inorganic carbon fixation pathway in both size fractions. Reconstruction of …

Exploring The Relationship Between Microdosing, Personality And Emotional Insight: A Prospective Study, Hannah M. Dressler, Stephen J. Bright, Vince Polito

Research outputs 2014 to 2021

Backround and aims: Having entered the recent public and research zeitgeist, microdosing involves consuming sub-perceptual doses of psychedelic drugs, allegedly to enhance performance, creativity, and wellbeing. The results of research to date have been mixed. Whereas most studies have reported positive impacts of microdosing, some microdosers have also reported adverse effects. In addition, research to date has revealed inconsistent patterns of change in personality traits. This prospective study explored the relationship between microdosing, personality change, and emotional awareness. Methods: Measures of personality and alexithymia were collected at two time points. 76 microdosers participated at baseline. Invitations to a follow-up survey …

Fifteen Years Of The Australian Imaging, Biomarkers And Lifestyle (Aibl) Study: Progress And Observations From 2,359 Older Adults Spanning The Spectrum From Cognitive Normality To Alzheimer's Disease, Christopher Fowler, Stephanie R. Rainey-Smith, Sabine Bird, Julia Bomke, Pierrick Bourgeat, Belinda M. Brown, Samantha C. Burnham, Ashley I. Bush, Carolyn Chadunow, Steven Collins, James Doecke, Vincent Doré, Kathryn A. Ellis, Lis Evered, Amir Fazlollahi, Jurgen Fripp, Samantha L. Gardener, Simon Gibson, Robert Grenfell, Elise Harrison, Richard Head, Liang Jin, Adrian Kamer, Fiona Lamb, Nicola T. Lautenschlager, Simon M. Laws, Qiao-Xin Li, Lucy Lim, Yen Ying Lim, Andrea Louey, S. Lance Macaulay, Lucy Mackintosh, Ralph N. Martins, Paul Maruff, Colin L. Masters, Simon Mcbride, Lidija Milicica, Madeline Peretti, Kelly Pertile, Tenielle Porter, Morgan Radler, Alan Rembach, Joanne Robertson, Mark Rodrigues, Christopher C. Rowe, Rebecca Rumble, Olivier Salvado, Greg Savage, Brendan Silbert, Magdalene Soh, Hamid R. Sohrabi, Kevin Taddei, Tania Taddei, Christine Thai, Brett Trounson, Regan Tyrrell, Michael Vacher, Shiji Varghese, Victor L. Villemagne, Michael Weinborn, Michael Woodward, Ying Xia, David Ames, Aibl Investigators

Research outputs 2014 to 2021

Background: The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study commenced in 2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild cognitive impairment (MCI), and 211 with Alzheimer's disease dementia (AD)) as an 'Inception cohort' who underwent detailed ssessments every 18 months. Over the past decade, an additional 1247 subjects have been added as an 'Enrichment cohort' (as of 10 April 2019). Objective: Here we provide an overview of these Inception and Enrichment cohorts of more than 8,500 person-years of investigation. Methods: Participants underwent reassessment every 18 months including comprehensive cognitive testing, neuroimaging (magnetic resonance …

Evolution, Ecology, And Zoonotic Transmission Of Betacoronaviruses: A Review, Herbert F. Jelinek, Mira Mousa, Eman Alefishat, Wael Osman, Ian Spence, Dengpan Bu, Samuel F. Feng, Jason Byrd, Paola A. Magni, Shafi Sahibzada, Guan K. Tay, Habiba S. Alsafar

Research outputs 2014 to 2021

Coronavirus infections have been a part of the animal kingdom for millennia. The difference emerging in the twenty-first century is that a greater number of novel coronaviruses are being discovered primarily due to more advanced technology and that a greater number can be transmitted to humans, either directly or via an intermediate host. This has a range of effects from annual infections that are mild to full-blown pandemics. This review compares the zoonotic potential and relationship between MERS, SARS-CoV, and SARS-CoV-2. The role of bats as possible host species and possible intermediate hosts including pangolins, civets, mink, birds, and other …

Aquatic Ecosystems Of The Anthropocene: Limnology And Microbial Ecology Of Mine Pit Lakes, Melanie L. Blanchette, Mark A. Lund

Research outputs 2014 to 2021

Mine pit lakes (‘pit lakes’) are new aquatic ecosystems of the Anthropocene. Potentially hundreds of meters deep, these lakes are prominent in the landscape and in the public consciousness. However, the ecology of pit lakes is underrepresented in the literature. The broad goal of this research was to determine the environmental drivers of pelagic microbe assemblages in Australian coal pit lakes. The overall experimental design was four lakes sampled three times, top and bottom, in 2019. Instrument chains were installed in lakes and measurements of in situ water quality and water samples for metals, metalloids, nutrients and microbe assemblage were …

Breaking The Silence: Insights Into The Lived Experiences Of Wa Aboriginal/Lgbtiq+ People: Community Summary Report 2021, Braden Hill, Bep Uink, Jenny Dodd, Dameyon Bonson, Anne-Marie Eades, Sian Bennett

Research outputs 2014 to 2021

The ‘Breaking the Silence’ research project is one of the first to focus on the unique experiences of Aboriginal and/or Torres Strait Islander LGBTIQ+ people living in Western Australia. Research focusing on the intersection of Indigeneity and gender/sexual diversity is severely lacking in Australia. This is the first survey to comprehensively capture the experiences of Aboriginal and Torres Strait Islander LGBTIQ+ Western Australians. Previously, major research pertaining to LGBTIQ+ Australians rarely just focused on Aboriginal and Torres Strait Islander same sex attracted or gender variant individuals (Bonson, 2017; Dudgeon, et. al., 2017; Growing Up Queer, 2014; Hill, et. al., 2021; …

Breaking The Silence: Insights From Wa Services Working With Aboriginal/ Lgbtiq+ People: Organisations Summary Report 2021, Braden Hill, Bep Uink, Jenny Dodd, Dameyon Bronson, Anne-Marie Eades, Sian Bennett

Research outputs 2014 to 2021

The ‘Breaking the Silence’ research project is one of the first to focus on the unique experiences of Aboriginal and/or Torres Strait Islander LGBTIQ+ people living in Western Australia. The report presents the first phase of a twopart research project that explores how a range of health, social support and education organisations respond to the needs of Aboriginal and/or Torres Strait Islander people, living in Western Australia and identifying as LGBTIQ+. This report presents the findings of focus groups, interviews and surveys with staff employed within a range of organisations that work closely with Aboriginal and/or LGBTIQ+ individuals. The discussion …

Summary Of Aboriginal And Torres Strait Islander Health Status - Selected Topics 2020, Australian Indigenous Healthinfonet

Research outputs 2014 to 2021

The Summary of Aboriginal and Torres Strait Islander health status - selected topics 2020 is a useful source of the most recent national information for health workers and those studying in the field. It provides general information regarding the health status of Aboriginal and Torres Strait Islander people across the following topics:

• social and cultural determinants
• births and deaths
• hospitalisations
• chronic conditions (including CVD, cancer, diabetes and kidney health)
• sexually transmitted infections
• environmental health
• social and emotional wellbeing
• alcohol and other drug use.

The Summary is based on the Overview of Aboriginal and Torres Strait Islander health status 2020 and …

Cardiovascular Safety Of Antifracture Medications In Patients With Osteoporosis: A Narrative Review Of Evidence From Randomized Studies, Alexander J. Rodríguez, Bo Abrahamsen

Research outputs 2014 to 2021

Osteoporosis and cardiovascular (CV) disease share common risk factors and pathophysiology. Low bone mineral density (BMD) and fractures appear to increase the risk for multiple CV diseases. Equally, prevalent CV disease appears to predispose to bone loss and increase fracture rates. This relationship has naturally provoked the hypothesis that stopping bone loss may result in some CV benefit. Secondary analyses of safety and adverse event data from many randomized controlled trials (RCTs) have attempted to clarify this putative association. Recently, the discontinuation of odanacatib (anti-cathepsin K monoclonal antibody) over stroke concerns and the imbalance in ischemic events in romosozumab-treated (anti-sclerostin …

Vaginal Microbial Profiling In A Preterm Birth High-Risk Cohort Using Shallow Shotgun Metagenomics, Alishum Ali, Claus T. Christophersen, Jeffrey A. Keelan

Research outputs 2014 to 2021

Preterm birth (PTB) is a significant health problem globally, with an estimate of 15 million cases annually. Approximately 10% of neonates born early will die prematurely, while a subset will develop severe life-long morbidities. Unfortunately, preterm birth's syndromic nature has evaded prevention strategies, and it continues to impose a high burden on healthcare systems and families. The role of vaginal bacteria in triggering biomolecular causes of PTB has been recognised for years. However, translating this knowledge to practical diagnostic and therapeutic strategies has remained elusive. New techniques in high-throughput sequencing have improved our understanding of the nature and role of …

Insights Into The Cultured Bacterial Fraction Of Corals, Michael Sweet, Helena Villela, Tina Keller-Costa, Rodrigo Costa, Stefano Romano, David G. Bourne, Anny Cárdenas, Megan J. Huggett, Allison H. Kerwin, Felicity Kuek, Mónica Medina, Julie L. Meyer, Moritz Müller, F. Joseph Pollock, Michael S. Rappé, Mathieu Sere, Koty H. Sharp, Christian R. Voolstra, Nathan Zaccardi, Maren Ziegler, Raquel Peixoto

Research outputs 2014 to 2021

Bacteria associated with coral hosts are diverse and abundant, with recent studies suggesting involvement of these symbionts in host resilience to anthropogenic stress. Despite their putative importance, the work dedicated to culturing coral-associated bacteria has received little attention. Combining published and unpublished data, here we report a comprehensive overview of the diversity and function of culturable bacteria isolated from corals originating from tropical, temperate, and cold-water habitats. A total of 3,055 isolates from 52 studies were considered by our metasurvey. Of these, 1,045 had full-length 16S rRNA gene sequences, spanning 138 formally described and 12 putatively novel bacterial genera across …

Dynamics And Fate Of Blue Carbon In A Mangrove–Seagrass Seascape: Influence Of Landscape Configuration And Land-Use Change, Maria E. Asplund, Martin Dahl, Rashid O. Ismail, Ariane Arias-Ortiz, Diana Deyanova, João N. Franco, Linus Hammar, Arielle I. Hoamby, Hans W. Linderholm, Liberatus D. Lyimo, Diana Perry, Lina M. Rasmusson, Samantha N. Ridgway, Gloria Salgado Gispert, Stéphanie D’Agata, Leah Glass, Jamal Angelot Mahafina, Volanirina Ramahery, Pere Masque, Mats Björk, Martin Gullström

Research outputs 2014 to 2021

Context: Seagrass meadows act as efficient natural carbon sinks by sequestering atmospheric CO and through trapping of allochthonous organic material, thereby preserving organic carbon (C ) in their sediments. Less understood is the influence of landscape configuration and transformation (land-use change) on carbon sequestration dynamics in coastal seascapes across the land–sea interface. Objectives: We explored the influence of landscape configuration and degradation of adjacent mangroves on the dynamics and fate of C in seagrass habitats. Methods: Through predictive modelling, we assessed sedimentary C content, stocks and source composition in multiple seascapes (km-wide buffer zones) dominated by different seagrass communities in …

Metabolomics And Lipidomics: Expanding The Molecular Landscape Of Exercise Biology, Mehdi R. Belhaj, Nathan G. Lawler, Nolan J. Hoffman

Research outputs 2014 to 2021

Dynamic changes in circulating and tissue metabolites and lipids occur in response to exercise-induced cellular and whole-body energy demands to maintain metabolic homeostasis. The metabolome and lipidome in a given biological system provides a molecular snapshot of these rapid and complex metabolic perturbations. The application of metabolomics and lipidomics to map the metabolic responses to an acute bout of aerobic/endurance or resistance exercise has dramatically expanded over the past decade thanks to major analytical advancements, with most exercise-related studies to date focused on analyzing human biofluids and tissues. Experimental and analytical con-siderations, as well as complementary studies using animal model …

Sensing Of Surface And Bulk Refractive Index Using Magnetophotonic Crystal With Hybrid Magneto-Optical Response, Daria Ignatyeva, Pavel Kapralov, Polina Golovko, Polina Shilina, Anastasiya Khramova, Sergey Sekatskii, Mohammad Nur-E-Alam, Kamal Alameh, Mikhail Vasiliev, Andrey Kalish, Vladimir Belotelov

Research outputs 2014 to 2021

We propose an all-dielectric magneto-photonic crystal with a hybrid magneto-optical response that allows for the simultaneous measurements of the surface and bulk refractive index of the analyzed substance. The approach is based on two different spectral features of the magneto-optical response corresponding to the resonances in p-and s-polarizations of the incident light. Angular spectra of p-polarized light have a step-like behavior near the total internal reflection angle which position is sensitive to the bulk refractive index. S-polarized light excites the TE-polarized optical Tamm surface mode localized in a submicron region near the photonic crystal surface and is sensitive to the …

Association Between Fruit And Vegetable Intakes And Mental Health In The Australian Diabetes Obesity And Lifestyle Cohort, Joanna Rees, Simone Radavelli-Bagatini, Johnny Lo, Jonathan M. Hodgson, Claus T. Christophersen, Robin M. Daly, Dianna J. Magliano, Jonathan E. Shaw, Marc Sim, Catherine P. Bondonno, Lauren C. Blekkenhorst, Joanne M. Dickson, Joshua R. Lewis, Amanda Devine

Research outputs 2014 to 2021

Increasing prevalence of mental health disorders within the Australian population is a serious public health issue. Adequate intake of fruits and vegetables (FV), dietary fibre (DF) and resistant starch (RS) is associated with better mental and physical health. Few longitudinal studies exist exploring the temporal relationship. Using a validated food frequency questionnaire, we examined baseline FV intakes of 5845 Australian adults from the AusDiab study and estimated food group-derived DF and RS using data from the literature. Perceived mental health was assessed at baseline and 5 year follow up using SF-36 mental component summary scores (MCS). We conducted baseline cross-sectional …

The Renaissance Of Odum's Outwelling Hypothesis In 'Blue Carbon' Science, Isaac R. Santos, David J. Burdige, Tim C. Jennerjahn, Steven Bouillon, Alex Cabral, Oscar Serrano, Thomas Wernberg, Karen Filbee-Dexter, Julia A. Guimond, Joseph J. Tamborski

Research outputs 2014 to 2021

The term ‘Blue Carbon’ was coined about a decade ago to highlight the important carbon sequestration capacity of coastal vegetated ecosystems. The term has paved the way for the development of programs and policies that preserve and restore these threatened coastal ecosystems for climate change mitigation. Blue carbon research has focused on quantifying carbon stocks and burial rates in sediments or accumulating as biomass. This focus on habitat-bound carbon led us to losing sight of the mobile blue carbon fraction. Oceans, the largest active reservoir of carbon, have become somewhat of a blind spot. Multiple recent investigations have revealed high …

Core Alzheimer’S Disease Cerebrospinal Fluid Biomarker Assays Are Not Affected By Aspiration Or Gravity Drip Extraction Methods, James D. Doecke, Cindy Francois, Christopher J. Fowler, Erik Stoops, Pierrick Bourgeat, Stephanie R. Rainey-Smith, Qiao-Xin Li, Colin L. Masters, Ralph N. Martins, Victor L. Villemagne, Steven J. Collins, Hugo Marcel Vanderstichele

Research outputs 2014 to 2021

Background: CSF biomarkers are well-established for routine clinical use, yet a paucity of comparative assessment exists regarding CSF extraction methods during lumbar puncture. Here, we compare in detail biomarker profiles in CSF extracted using either gravity drip or aspiration. Methods: Biomarkers for β-amyloidopathy (Aβ1–42, Aβ1–40), tauopathy (total tau), or synapse pathology (BACE1, Neurogranin Trunc-p75, α-synuclein) were assessed between gravity or aspiration extraction methods in a sub-population of the Australian Imaging, Biomarkers and Lifestyle (AIBL) study (cognitively normal, N = 36; mild cognitive impairment, N = 8; Alzheimer’s disease, N = 6). Results: High biomarker concordance between extraction methods was seen …