Digital Commons Network^™

Hands And Health: Quantifying Occupational Exposures And Implications Of Disability, Sueann R. Woods

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: Hand grip strength (HGS) has been negatively correlated with both biologic, cognitive, and mental health markers. Aim one investigated how occupational metabolic equivalents (OMETs), impacted HGS. Aim two investigated lost time from work and the association with HGS. Finally, aim three investigated the health outcomes of workers’ compensation claimants who have lost time from work, following diagnosis of CTS.

Results:HGS was positively associated with OMET (rs = 0.078, p = 0.009). Linear regression model demonstrated a statistically significant association between HGS and OMETs, F(1, 31) = 9.735, p = .001. Aim two found that all occupation groups had …

Psychometric Evaluation Of Genetic Literacy Instruments In A National Sample, Jamey T. Brumbaugh

Graduate Theses, Dissertations, and Problem Reports (ETD)

The concept of genetic literacy continues to grow in clinical and social significance. Whether transforming current healthcare practices or raising questions about genetically-modified foods, genetic information and technologies are primed to further influence people’s lives. There is a growing need to understand how genetic literacy is currently assessed in order to inform and improve future test development. This study aimed to investigate the assessment of genetic literacy by psychometrically examining three contemporary genetic literacy instruments (i.e., Genetic Knowledge Survey, International Genetic Literacy and Attitudes Survey (iGLAS-GK), and University of North Carolina Genomic Knowledge Scale (UNC-GKS). Psychometric properties, including internal consistency …

Effects Of Biofertilizer On Soil Nutrient Cycling And The Productivity Of Bioproduct Crops In Marginal Soils, Kieran B. Liseski

Graduate Theses, Dissertations, and Problem Reports (ETD)

Recently there has been increased interest in the use of marginal lands in order to grow bioproduct crops. Utilizing marginal lands to grow bioproduct crops such as Miscanthus x giganteus and Panicum virgatum could not only improve soil quality and minimize negative environmental impacts on the surrounding ecosystems but could also offer economic benefits to growers in rural areas. Because marginal soils tend to reduce crop yields compared to prime farmlands even when growing bioproduct crops, which tend to be more robust than traditional food crops, augmenting the soil with biofertilizers (i.e., the direct addition of viable microbial cells) could …

Examining Relationships Among Person Factors, Psychosocial Factors, And Coping Patterns In People Living With Type 2 Diabetes Mellitus In North Central Appalachia, Melissa A. Mccoy

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Diabetes is a complex, debilitating illness that imposes disease burden on the individual and society. T2DM is more prevalent in the Appalachian region than in any other Region of the United States. If diabetes is poorly controlled, patients are at risk for negative health outcomes. A gap exists in the literature related to understanding of the relationships among person factors, psychosocial factors, and coping patterns. Another gap in the literature is sex differences among these variables.

Purpose: The purpose of this study is to examining relationships among person factors, psychosocial factors, and coping patterns in people living with T2DM …

Insect Community Associated With Black Cherry (Prunus Serotina) In The Allegheny National Forest, Craig James Larcenaire

Graduate Theses, Dissertations, and Problem Reports (ETD)

Black cherry (Prunus serotina Ehrh.) is valuable species managed for its economic and ecologic benefits. This species grows best in the environment of the Allegheny Plateau region in northwestern Pennsylvania. Land managers on the Allegheny National Forest (ANF) have been managing black cherry for a variety of goals and purposes. Over the last few decades, the land managers have noticed a decline in the natural regeneration of black cherry in the forest. Because the black cherry flowers are self-incompatible and require animal pollinators to transfer the pollen from one tree to another one hypothesis for this decline could be …

A Survey Of Musical Expectations In The Marine Forces Reserve Band Stationed In New Orleans, Louisiana, Brandon Paul Carbonari

Graduate Theses, Dissertations, and Problem Reports (ETD)

This research document examines the musical expectations of United States Marines serving in the Marine Forces Reserve Band from 2017 to 2021. Chapter One of this study provides a detailed foundation of the musical and non-musical responsibilities of a United States Marine musician. Training regime, rehearsal schedule, and logistical area responsibilities will be described to help convey the full scope of duty. The source material for Chapter One includes dissertations, journal articles, published books, online sources, and interviews. Chapter Two provides results of a survey that was conducted with members of the band. The questions were designed to record the …

Improving Broiler Performance And Digestibility Through Feed Enzymes And Production Rate Aids Utilized In Pelleting., Kristina Marie Bowen

Graduate Theses, Dissertations, and Problem Reports (ETD)

Enzymes are commonly added to poultry diets to improve performance parameters that may in turn decrease costs to the producer. Pellet mill production rate aids are also utilized to reduce feed manufacture costs and may have additional benefits when fed to poultry that are associated with the increase in production rate. Past research has shown that Azomite (AZM) can increase pellet mill production rate in diets that include inorganic phosphate sources (IPS) of dicalcium phosphate (DCP) or tricalcium phosphate (TCP). In the first experiment the authors hypothesized that if production rate were held constant then pellet mill energy consumption would …

Transgender Rights & The Eighth Amendment, Jennifer Levi, Kevin M. Barry

Faculty Scholarship

The past decades have witnessed a dramatic shift in the visibility, acceptance, and integration of transgender people across all aspects of culture and the law. The treatment of incarcerated transgender people is no exception. Historically, transgender people have been routinely denied access to medically necessary hormone therapy, surgery, and other gender-affirming procedures; subjected to cross-gender strip searches; and housed according to their birth sex. But these policies and practices have begun to change. State departments of corrections are now providing some, though by no means all, appropriate care to transgender people, culminating in the Ninth Circuit’s historic decision in Edmo …

Mucins, Gut Microbiota, And Postbiotics Role In Colorectal Cancer, Ramesh Pothuraju, Sanjib Chaudhary, Satyanarayana Rachagani, Sukhwinder Kaur, Hemant K Roy, Michael Bouvet, Surinder K Batra

Faculty, Staff and Students Publications

An imbalance in the crosstalk between the host and gut microbiota affects the intestinal barrier function, which results in inflammatory diseases and colorectal cancer. The colon epithelium protects itself from a harsh environment and various pathogenic organisms by forming a double mucus layer, primarily comprising mucins. Recent studies are focusing on how dietary patterns alter the gut microbiota composition, which in turn regulates mucin expression and maintains the intestinal layers. In addition, modulation of gut microbiota by microbiotic therapy (involving fecal microbiota transplantation) has emerged as a significant factor in the pathologies associated with dysbiosis. Therefore, proper communication between host …

Case Report: Dupilumab Successfully Controls Severe Eczema In A Child With Elevated Ige Levels And Recurrent Skin Infections, Tejas P Joshi, Sara Anvari, Meera R Gupta, Carla M Davis, Joud Hajjar

Faculty, Staff and Students Publications

The efficacy of dupilumab in pediatric patients with severe eczema presenting in the setting of elevated immunoglobulin E (IgE) levels and recurrent bacterial skin infections is not well-understood. Here we present the case of a child with elevated IgE levels in whom dupilumab treatment led to remarkable control of his eczema and recurrent skin infections. We also review the use of dupilumab in other patients with molecularly proven cases of hyper IgE (HIGE) syndrome. Our case supports the notion that dupilumab may have a seminal application in treating severe eczema that occurs in the setting of elevated IgE levels and …

Swimming Against The Flow: Environmental Dna Can Detect Bull Sharks (Carcharhinus Leucas) Across A Dynamic Deltaic Interface, James Marcus Drymon, Katherine E. Schweiss, Emily A. Seubert, Ryan N. Lehman, Toby S. Daly-Engel, Mariah Pfleger, Nicole M. Phillips

Faculty Publications

© 2020 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd Human activities in coastal areas are accelerating ecosystem changes at an unprecedented pace, resulting in habitat loss, hydrological modifications, and predatory species declines. Understanding how these changes potentially cascade across marine and freshwater ecosystems requires knowing how mobile euryhaline species link these seemingly disparate systems. As upper trophic level predators, bull sharks (Carcharhinus leucas) play a crucial role in marine and freshwater ecosystem health. Telemetry studies in Mobile Bay, Alabama, suggest that bull sharks extensively use the northern portions of the bay, an estuarine–freshwater interface known …

A Story Of Bodying In Science Education, Christie C. Byers, Maria F.G. Wallace

Faculty Publications

In poetic dialogue with BecomingAlivewithinScienceEducation(Research):ThinkingwithLifeHistory(ies),BodiesandStickiness, stories of bodying and body(ies) of work are playfully explored.

Who Owns Ocean Biodiversity?: The Legal Status And Role Of Patents As A Means To Achieve Equitable Distribution Of Benefits, Abhaya Ganashree

Case Western Reserve Journal of International Law

No abstract provided.

The Role Of International Organizations In The Development Of International Environmental Law: Adjusting The Lenses Of Analysis, Rita Guerreiro Teixeira

Case Western Reserve Journal of International Law

No abstract provided.

A Codex Of N-And P-Positions In Harary’S ‘Caterpillar Game’, Richard M. Low, Ardak Kapbasov, Arman Kapbasov, Stephen C. Locke, W. H. Chan

Faculty Research, Scholarly, and Creative Activity

Frank Harary proposed the following game: Given a caterpillar C, two players take turns removing edges of a path. The player who takes the last edge wins the game. In this paper, we completely characterize the N-and P-positions for all caterpillars with spine length zero, one, two and three. Furthermore, we analyze approximately 94% of the caterpillars with spine length greater than or equal to four. In those cases, they all turn out to be N-positions.

Flight Crew Alertness And Sleep Relative To Timing Of In-Flight Rest Periods In Long-Haul Flights, Kevin B. Gregory, Rhiannon N. Soriano-Smith, Amanda C.M. Lamp, Cassie J. Hilditch, Michael J. Rempe, Erin E. Flynn-Evans, Gregory L. Belenky

Faculty Research, Scholarly, and Creative Activity

BACKGROUND: In-flight breaks are used during augmented long-haul flight operations, allowing pilots a sleep opportunity. The U.S. Federal Aviation Administration duty and rest regulations restrict the pilot flying the landing to using the third rest break. It is unclear how effective these restrictions are on pilots’ ability to obtain sleep. We hypothesized there would be no difference in self-reported sleep, alertness, and fatigue between pilots taking the second vs. third rest breaks. METHODS: Pilots flying augmented operations in two U.S.-based commercial airlines were eligible for the study. Volunteers completed a survey at top-of-descent (TOD), including self-reported in-flight sleep duration, and …

Comparison Of Growth Performance And Meat Quality Traits Of Commercial Cross-Bred Pigs Versus The Large Black Pig Breed, Yongjie Wang, Keshari Thakali, Palika Morse, Sarah Shelby, Jinglong Chen, Jason Apple, Yan Huang

Animal Science Faculty Publications and Presentations

The meat quality of different pig breeds is associated with their different muscle tissue physiological processes, which involves a large variety of genes related with muscle fat and energy metabolism. Understanding the differences of biological processes of muscle after slaughter is helpful to reveal the meat quality development of different breeds. Therefore, eight native Large Black pigs (BP), with high fat content in meat, and seven cross-bred commercial pigs (CP), which had a high feed efficiency with high lean meat, were used to investigate the differences in their meat quality and RNA transcriptomes. The average daily gain (ADG) and hot …

Open Problems In Extracellular Rna Data Analysis: Insights From An Ercc Online Workshop, Roger P Alexander, Robert R Kitchen, Juan Pablo Tosar, Matthew Roth, Pieter Mestdagh, Klaas E A Max, Joel Rozowsky, Karolina Elżbieta Kaczor-Urbanowicz, Justin Chang, Leonora Balaj, Bojan Losic, Eric L Van Nostrand, Emily Laplante, Bogdan Mateescu, Brian S White, Rongshan Yu, Aleksander Milosavljevic, Gustavo Stolovitzky, Ryan M Spengler

Faculty, Staff and Students Publications

We now know RNA can survive the harsh environment of biofluids when encapsulated in vesicles or by associating with lipoproteins or RNA binding proteins. These extracellular RNA (exRNA) play a role in intercellular signaling, serve as biomarkers of disease, and form the basis of new strategies for disease treatment. The Extracellular RNA Communication Consortium (ERCC) hosted a two-day online workshop (April 19–20, 2021) on the unique challenges of exRNA data analysis. The goal was to foster an open dialog about best practices and discuss open problems in the field, focusing initially on small exRNA sequencing data. Video recordings of workshop …

Genomic Mapping Of Dna-Repair Reaction Intermediates In Living Cells With Engineered Dna Structure-Trap Proteins, Jingjing Liu, Qian Mei, Sadeieh Nimer, Devon M Fitzgerald, Susan M Rosenberg

Faculty, Staff and Students Publications

Diverse DNA structures occur as reaction intermediates in various DNA-damage and -repair mechanisms, most of which results from replication stress. We harness the power of proteins evolutionarily optimized to bind and "trap" specific DNA reaction-intermediate structures, to quantify the structures, and discern the mechanisms of their occurrence in cells. The engineered proteins also allow genomic mapping of sites at which specific DNA structures occur preferentially, using a structure-trapping protein and ChIP-seq- or Cut-and-Tag-like methods. Genome-wide identification of sites with recurrent DNA-damage intermediates has illuminated mechanisms implicated in genome instability, replication stress, and chromosome fragility. Here, we describe X-seq, for identifying …

Kv13 Channel Up-Regulation In Peripheral Blood T Lymphocytes Of Patients With Multiple Sclerosis, Ioannis Markakis, Ioannis Charitakis, Christine Beeton, Melpomeni Galani, Elpida Repousi, Stella Aggeloglou, Petros P Sfikakis, Michael W Pennington, K George Chandy, Cornelia Poulopoulou

Faculty, Staff and Students Publications

Voltage-gated Kv1.3 potassium channels are key regulators of T lymphocyte activation, proliferation and cytokine production, by providing the necessary membrane hyper-polarization for calcium influx following immune stimulation. It is noteworthy that an accumulating body of in vivo and in vitro evidence links these channels to multiple sclerosis pathophysiology. Here we studied the electrophysiological properties and the transcriptional and translational expression of T lymphocyte Kv1.3 channels in multiple sclerosis, by combining patch clamp recordings, reverse transcription polymerase chain reaction and flow cytometry on freshly isolated peripheral blood T lymphocytes from two patient cohorts with multiple sclerosis, as well as from healthy …

What Lies Beneath: Predicting Seagrass Below-Ground Biomass From Above-Ground Biomass, Environmental Conditions And Seagrass Community Composition, C. J. Collier, L. M. Langlois, Kathryn M. Mcmahon, J. Udy, M. Rasheed, E. Lawrence, A. B. Carter, M. W. Fraser, L. J. Mckenzie

Research outputs 2014 to 2021

© 2020 Seagrass condition, resilience and ecosystem services are affected by the below-ground tissues (BGr) but these are rarely monitored. In this study we compiled historical data across northern Australia to investigate biomass allocation strategies in 13 tropical seagrass species. There was sufficient data to undertake statistical analysis for five species: Cymodocea serrulata, Halophila ovalis, Halodule uninervis, Thalassia hemprichii, and Zostera muelleri. The response of below-ground biomass (BGr) to above-ground biomass (AGr) and other environmental and seagrass community composition predictor variables were assessed using Generalized Linear Models. Environmental data included: region, season, sediment type, water depth, proximity to land-based sources …

Comparison Of Circulating Tumour Dna And Extracellular Vesicle Dna By Low-Pass Whole-Genome Sequencing Reveals Molecular Drivers Of Disease In A Breast Cancer Patient, Olivia Ruhen, Bob Mirzai, Michael E. Clark, Bella Nguyen, Carlos Salomon, Wendy Erber, Katie Meehan

Research outputs 2014 to 2021

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. There is increasing recognition of circulating tumour DNA (ctDNA) as a non-invasive alternative to tumour tissue for the molecular characterisation and monitoring of disease. Recent evidence suggests that cancer-associated changes can also be detected in the DNA contained within extracellular vesicles (EVs). As yet, there has been limited investigation into the relationship between EV DNA and ctDNA, and no studies have examined the EV DNA of breast cancer patients. The aim of this study was to use low-pass whole-genome sequencing to identify copy number variants (CNVs) in serial samples of both …

Titanium Nitride Thin Film Based Low‐Redox‐Interference Potentiometric Ph Sensing Electrodes, Shimrith Paul Shylendra, Wade Lonsdale, Magdalena Wajrak, Mohammad Nur‐E‐Alam, Kamal Alameh

Research outputs 2014 to 2021

© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

In this work, a solid‐state potentiometric pH sensor is designed by incorporating a thin film of Radio Frequency Magnetron Sputtered (RFMS) Titanium Nitride (TiN) working electrode and a commercial Ag|AgCl|KCl double junction reference electrode. The sensor shows a linear pH slope of −59.1 mV/pH, R2 = 0.9997, a hysteresis as low as 1.2 mV, and drift below 3.9 mV/hr. In addition, the redox interference performance of TiN electrodes is compared with that of Iridium Oxide (IrO2) counterparts. Experimental results show −32mV potential shift (E0 value) in 1 mM ascorbic acid (reducing …

To Dine In Or Not To Dine In: A Comparison Of Food Selection And Preparation Behaviours In Those With And Without Food Security, Lucy M. Butcher, Therese A. O’Sullivan, Maria M. Ryan, Johnny Lo, Julie Nyanjom, Hugh C. Wilkins, Amanda Devine

Research outputs 2014 to 2021

© 2020 The Authors. Health Promotion Journal of Australia published by John Wiley & Sons Australia, Ltd on behalf of Australian Health Promotion Association Issue addressed: Vulnerable populations are disproportionately affected by food insecurity, resulting in heightened risk of suboptimal dietary intake. Food insecure people appear to implement several coping strategies and dietary compromises to avoid hunger. Less explored in the literature is how these strategies impact consumption of food inside and outside of the home. Methods: An online survey was completed by adults (n = 1292) residing in one of five Australian states. The questionnaire comprised of the six-item …

Persistence Of Biogeochemical Alterations Of Deep-Sea Sediments By Bottom Trawling, S. Paradis, M. Goñi, Pere Masqué, R. Durán, M. Arjona-Camas, A. Palanques, P. Puig

Research outputs 2014 to 2021

Bottom trawling grounds have been expanding to deeper areas of the oceans since the mid-XXth century, and mitigating strategies aimed to protect fish stocks, such as temporal trawling closures, have recently been implemented. Here we investigated the biogeochemical properties of sediment from a deep-sea trawling ground in Palamós Canyon (NW Mediterranean) to assess the effects of a 2-months trawling closure in the recovery of sedimentary organic matter. In comparison to untrawled areas, the continuous erosion and sediment mixing in trawling grounds led to coarser reworked sediments impoverished in organic carbon (∼30% loss) and promoted the degradation of labile compounds (52–70% …

Rethinking Immune Checkpoint Blockade: Beyond The T Cell, Xiuting Liu, Graham D Hogg, David G Denardo

2020-Current year OA Pubs

The clinical success of immune checkpoint inhibitors has highlighted the central role of the immune system in cancer control. Immune checkpoint inhibitors can reinvigorate anti-cancer immunity and are now the standard of care in a number of malignancies. However, research on immune checkpoint blockade has largely been framed with the central dogma that checkpoint therapies intrinsically target the T cell, triggering the tumoricidal potential of the adaptive immune system. Although T cells undoubtedly remain a critical piece of the story, mounting evidence, reviewed herein, indicates that much of the efficacy of checkpoint therapies may be attributable to the innate immune …

Disease-Modifying Therapy Prescription Patterns In People With Multiple Sclerosis By Age, Yinan Zhang, Amber Salter, Shan Jin, William J Culpepper, Gary R Cutter, Mitchell Wallin, Olaf Stuve

2020-Current year OA Pubs

BACKGROUND: Disease-modifying therapies (DMTs) for multiple sclerosis (MS) are approved for their ability to reduce disease activity, namely clinical relapses and signal changes on magnetic resonance imaging (MRI). Disease activity appears age dependent. Thus, the greatest benefit would be expected in younger people with MS (PwMS) whereas benefits in the elderly are uncertain.

METHODS: Real-world data were obtained from PwMS from the North American Research Committee on Multiple Sclerosis (NARCOMS) registry and the US Department of Veterans Affairs Multiple Sclerosis Surveillance Registry (MSSR).

RESULTS: 6948 PwMS were surveyed from NARCOMS, and the MSSR had 1719 participants. In younger adult PwMS …

Quantifying Egg Attendance Behaviours Of Wild Asian Houbara Can Improve Artificial Incubation Outcomes, Robert J. Burnside, Scott A. Shaffer, Francesc Cusco, Masudur Rahman, Keith M. Scotland

Faculty Research, Scholarly, and Creative Activity

Artificial incubation is fundamental in ex situ avian conservation interventions for an increasing range of threatened species, but incubation parameters can differ between species. Both egg-turning angle and frequency are critical for successful embryonic development, but measuring these parameters in wild birds has historically been difficult. Using data-loggers inside artificial eggs that accurately record parental egg attendance behaviours, we quantified turning angles and rates throughout the incubation of 6 nesting wild Asian houbaras Chlamydotis mac-queenii, a species bred in captivity in response to human over-exploitation. Wild females turned their eggs 0.6 times h-1 with a mean angle of 40.9° turn-1. …

Racial And Social Justice At San José State University: Students Respond With Social Action, Scott Myers-Lipton, William Armaline

Faculty Research, Scholarly, and Creative Activity

No abstract provided.

Malware Classification With Word Embedding Features, Aparna Sunil Kale, Fabio Di Troia, Mark Stamp

Faculty Research, Scholarly, and Creative Activity

Malware classification is an important and challenging problem in information security. Modern malware classification techniques rely on machine learning models that can be trained on features such as opcode sequences, API calls, and byte n-grams, among many others. In this research, we consider opcode features. We implement hybrid machine learning techniques, where we engineer feature vectors by training hidden Markov models—a technique that we refer to as HMM2Vec—and Word2Vec embeddings on these opcode sequences. The resulting HMM2Vec and Word2Vec embedding vectors are then used as features for classification algorithms. Specifically, we consider support vector machine (SVM), k-nearest neighbor (k-NN), random …