Digital Commons Network^™

A Prospective Pilot Study Of The Energy Balance Profiles In Acute Non-Severe Burn Patients, Tyler Osborne, Dale Edgar, Paul Gittings, Fiona Wood, Thomas Le Huray, Brodie Allan, Brendan R. Scott, Bradley Wall

IHR Papers and Journal Articles

Background:Major burn patients have been shown to exhibit a hyper-metabolic state of activity which can persist for up to two years after burn. The relationship between total body surface area (TBSA) and resting metabolic rate (RMR) has been investigated in larger burns (≥20% TBSA), however not in non-severe burns (≤15% TBSA). The primary aim of this observational study was to examine the association between the acute effects of burns

Methods: The study included data from 39 participants (82% male), all admitted to the State Adult Burn Unit at Fiona Stanley Hospital. Each patient was recruited upon admission and RMR …

Influence Of Age And Maturation Status On Sprint Acceleration Characteristics In Junior Australian Football, Toby Edwards, Jonathon Weakley, Harry G. Banyard, Ashley Cripps, Benjamin Piggott, G. Gregory Haff, Christopher Joyce

Health Sciences Papers and Journal Articles

This study aimed to investigate the influence of chronological age and maturation status on sprint acceleration characteristics in junior Australian football (AF) players. Biological maturity of 109 subjects was assessed and subjects were grouped according to predicted years from peak height velocity (PHV) (pre-, mid-, and post-PHV) and chronological age (13 years, 14 years, and 15 years). A one-way multivariate analysis of variance and magnitude-based decisions were used to determine between-group differences. Instantaneous velocity was measured during two maximal 30m sprints via radar gun with the velocity-time data used to derive the force, velocity, and power characteristics. Chronologically, the greatest …

Microbial Contaminants In Wild Harvested And Traded Edible Long-Horned Grasshopper, Ruspolia Differens (Orthoptera: Tettigoniidae) In Uganda, S. Labu, S. Subramanian, F. M. Khamis, P. Akite, P. Kasangaki, M. Chemurot, C. M. Tanga, F. L.O. Ombura, J. P. Egonyu

All Peer-Reviewed Publications

This study investigated the relative abundance and identity of microbial contaminants of the edible long-horned grasshopper (Ruspolia differens) harvested from the wild and traded in informal markets in Uganda, to reveal high health risk points. Raw samples of whole R. differens were collected from wild vegetation, trapping sites and markets. Additionally, samples of plucked and deep-fried ready-to-eat R. differens were collected from the markets. The samples were cultured on standard media for microbial quantification, and pure cultures were characterised using molecular techniques. Bacterial and fungal counts in deep fried ready-to-eat R. differens were ~3 and 2-fold lower, respectively, than in …

Black Soldier Fly Larval Meal In Feed Enhances Growth Performance, Carcass Yield And Meat Quality Of Finishing Pigs, S. Y. Chia, C. M. Tanga, I. M. Osuga, A. O. Alaru, D. M. Mwangi, M. Githinji, T. Dubois, S. Ekesi, J. J.A. Van Loon, M. Dicke

All Peer-Reviewed Publications

Using black soldier fly (BSF, Hermetia illucens) larvae as a novel protein source substituting fishmeal (FM) in animal feeds is globally gaining momentum. BSF can be reared on agro-industrial residues. However, incorporating BSF larval meal (BSFLM) into finisher pig diets has received inadequate attention. This study evaluated the effects of replacing dietary FM with BSFLM on growth, carcass traits and meat quality of finisher pigs. A control diet (including FM: 0% BSFLM) was compared with four dietary levels of replacement of FM with BSFLM at 25, 50, 75 or 100%. Forty hybrid pigs (crossbreeds of purebred Large White and Landrace) …

Prevalence Of Asymptomatic P. Falciparum Gametocyte Carriage Among School Children In Mbita, Western Kenya And Assessment Of The Association Between Gametocyte Density, Multiplicity Of Infection And Mosquito Infection Prevalence., Victor A. Mobegi, Jeremy K. Herren, Abdoulie O. Touray, Fred Wamunyokoli, Hellen Butungi

All Peer-Reviewed Publications

Background: Asymptomatic Plasmodium falciparum gametocyte carriers are reservoirs for sustaining transmission in malaria endemic regions. Gametocyte presence in the host peripheral blood is a predictor of capacity to transmit malaria. However, it does not always directly translate to mosquito infectivity. Factors that affect mosquito infectivity include, gametocyte sex-ratio and density, multiplicity of infection (MOI), and host and vector anti-parasite immunity. We assess the prevalence of gametocyte carriage and some of its associated risk factors among asymptomatic schoolchildren in Western Kenya and to further analyse the association between gametocyte density, multiplicity of infection (MOI) and mosquito infection prevalence. Methods: P. falciparum …

Τhe Complete Mitochondrial Genomes Of Ceratitis Rosa And Ceratitis Quilicii, Members Of The Ceratitis Far Species Complex (Diptera: Tephritidae), Elena Drosopoulou, Aristi Damaskou, Angeliki Markou, Sunday Ekesi, Fathiya Khamis, Aruna Manrakhan, Antonios A. Augustinos, George Tsiamis, Kostas Bourtzis

All Peer-Reviewed Publications

Ceratitis FAR is an African species complex comprising insect pests of great economic interest and obscure species limits. Here, we report the mitochondrial genomes of two members of the FAR complex, namely Ceratitis rosa and the recently characterized Ceratitis quilicii. A phylogenetic analysis based on PCGs of available Tephritidae mitogenomes is presented. The current mitochondrial sequences from the FAR complex could contribute toward the resolution of phylogenetic relationships and species limits within this taxonomically challenging group, which is also an important issue for the development of environment-friendly and species-specific control methods, such as the sterile insect technique (SIT).

Cocoyam (Colocasia Esculenta) Provides An Effective Monoxenic Culture Media For Radopholus Similis, Celestine A. Oduori, Janet Atandi, James Kisaakye, Danny Coyne

All Peer-Reviewed Publications

The burrowing nematode, Radopholus similis, is the most economically important nematode parasite of bananas, in addition to parasitising a range of other crops (Coyne & Kidane, 2018). Weakened, infected roots result in poor plant development and they are less able to provide anchorage to banana plants, which can lead to toppling of the entire plant. To enable research activities, such as resistance screening and efficacy studies, a readily available supply of inoculum is required for timely use in experiments. O’Bannon & Taylor (1968) developed the sterile carrot disc technique for the monoxenic culture of R. similis to support such routine …

Revisiting The Modified Baermann Extraction Method: Extraction Efficiency Of Radopholus Similis Using Different Extraction Materials, Kanan Saikai, Situma Wanjala, Celestine Oduori, Danny Coyne

All Peer-Reviewed Publications

In order to determine the threat that plant-parasitic nematodes pose to crop production, it is essential to establish an accurate estimation of their presence. The extraction efficiency from soil, therefore, is a critical step in establishing disease pressures presented by nematodes or the conditions of soil health. To achieve high nematode extraction efficiency, various methods and modifications have been developed over time (Oostenbrink, 1954; Seinhorst, 1956; Harrison & Green, 1976; Viaene et al., 2021) with variations being introduced locally, depending on the availability or access to certain materials. The simple extraction method was conceived and introduced by Baermann (1917), with …

Affordable Processing Of Edible Orthopterans Provides A Highly Nutritive Source Of Food Ingredients, Forkwa Tengweh Fombong, John Kinyuru, Jeremiah Ng’Ang’A, Monica Ayieko, Chrysantus Mbi Tanga, Jozef Vanden Broeck, Mik Van Der Borght

All Peer-Reviewed Publications

Edible orthopterans (grasshoppers, crickets, and locusts) are major delicacies, especially across sub-Saharan Africa. Their promotion as food ingredients is increasingly gaining momentum. This study evaluates the nutritional profiles of three widely consumed orthopterans: Gryllus bimacu-latus, Locusta migratoria, and Schistocerca gregaria after blanching and oven-drying. All three species had high protein (65.3, 54.2, and 61.4% on a dry matter (DM) basis for G. bimaculatus, L. migratoria, and S. gregaria, respectively) and fat contents. Oleic (22.9–40.8%) and palmitic (26.1–43.0%) were the two most abundant fatty acids. All essential amino acids (in mg/100 g protein) were present, with glutamic acid (120–131), alanine (90.2–123), …

Effect Of Alternative Rearing Substrates And Temperature On Growth And Development Of The Cricket Modicogryllus Conspersus (Schaum), G. Ssepuuya, F. Sengendo, C. Ndagire, J. Karungi, K. K.M. Fiaboe, J. Efitre, D. Nakimbugwe

All Peer-Reviewed Publications

The increasing demand for animal protein in sub-Saharan Africa has led to insects being considered an alternative protein source for food and feed. In Uganda, chicken mash, containing fish meal as the protein source is commonly used to rear crickets. However, fishmeal is an expensive protein source that is also human food. This study therefore aimed at establishing an alternative preferred (consumed in the highest quantity) plant leaf diet for raising the Modicogryllus conspersus cricket, and the most suitable temperature for hatchability and egg development. The effect of (a) three diets (cassava leaves + cocoyam leaves + milk weed leaves; …

An Overview Of Antimicrobial Compounds From African Edible Insects And Their Associated Microbiota, Cynthia M. Mudalungu, Chrysantus M. Tanga, Segenet Kelemu, Baldwyn Torto

All Peer-Reviewed Publications

The need for easily biodegradable and less toxic chemicals in drug development and pest control continues to fuel the exploration and discovery of new natural molecules. Like certain plants, some insects can also respond rapidly to microbial infections by producing a plethora of immune-induced molecules that include antibacterial and antifungal peptides/polypeptides (AMPs), among other structurally diverse small molecules. The recent recognition that new natural product-derived scaffolds are urgently needed to tackle life-threatening pathogenic infections has been prompted by the health threats posed by multidrug resistance. Although many researchers have concentrated on the discovery of AMPs, surprisingly, edible insect-produced AMPs/small molecules …

Effects Of Tidal Flooding On Estuarine Biogeochemistry: Quantifying Flood-Driven Nitrogen Inputs In An Urban, Lower Chesapeake Bay Sub-Tributary, Alfonso Macías-Tapia, Margaret R. Mulholland, Corday R. Selden, J. Derek Loftis, Peter W. Bernhardt

OES Faculty Publications

Sea level rise has increased the frequency of tidal flooding even without accompanying precipitation in many coastal areas worldwide. As the tide rises, inundates the landscape, and then recedes, it can transport organic and inorganic matter between terrestrial systems and adjacent aquatic environments. However, the chemical and biological effects of tidal flooding on urban estuarine systems remain poorly constrained. Here, we provide the first extensive quantification of floodwater nutrient concentrations during a tidal flooding event and estimate the nitrogen (N) loading to the Lafayette River, an urban tidal sub-tributary of the lower Chesapeake Bay (USA). To enable the scale of …

Prevalence And Factors Associated With Mental Health Symptoms In Adults Undergoing Covid-19 Testing, Ikponmwosa Osaghae, Linh K Nguyen, Tong Han Chung, Olivia Moffitt, Yen-Chi L Le, Mark B Suh, Pooja N Prasad, Eric J Thomas, Christine D Gordon, Kevin O Hwang

Faculty, Staff and Student Publications

BACKGROUND AND OBJECTIVE: Understanding the mental health impact of the COVID-19 pandemic on persons receiving COVID-19 testing will help guide mental health interventions. We aimed to determine the association between sociodemographic factors and mental health symptoms at 8 weeks (baseline) after a COVID-19 test, and compare prevalence of mental health symptoms at baseline to those at 16-week follow-up.

MATERIALS AND METHODS: Prospective cohort study of adults who received outpatient COVID-19 testing at primary care clinics. Logistic regression analyses were used to assess the association between sociodemographic characteristics and COVID-19 test results with mental health symptoms. Mental health symptoms reported at …

Correlation Between Concentrations Of Four Heavy Metals In Cord Blood And Childhood Blood Of Jamaican Children, Mohammad H Rahbar, Maureen Samms-Vaughan, Manouchehr Hessabi, Jan Bressler, Shezeen Gillani, Megan L Grove, Sydonnie Shakspeare-Pellington, Katherine A Loveland

Faculty, Staff and Student Publications

This study investigated whether the concentrations of four metals [lead (Pb), mercury (Hg), manganese (Mn), and aluminum (Al)] are correlated in cord blood and childhood blood samples from Jamaican children. Cord blood samples were obtained from 21 pregnant women enrolled in the second Jamaican Birth Cohort Study from July 1, 2011 to September 30, 2011, and blood samples were drawn from their children who participated in a follow up study when the children were 4–8 years old. Correlations were assessed by the Pearson or the Spearman’s rank correlation coefficient. The mean ages of children at the childhood visit and their …

Endmt Regulation By Small Rnas In Diabetes-Associated Fibrotic Conditions: Potential Link With Oxidative Stress, Roberta Giordo, Yusra M A Ahmed, Hilda Allam, Salah Abusnana, Lucia Pappalardo, Gheyath K Nasrallah, Arduino Aleksander Mangoni, Gianfranco Pintus

Faculty, Staff and Student Publications

Diabetes-associated complications, such as retinopathy, nephropathy, cardiomyopathy, and atherosclerosis, the main consequences of long-term hyperglycemia, often lead to organ dysfunction, disability, and increased mortality. A common denominator of these complications is the myofibroblast-driven excessive deposition of extracellular matrix proteins. Although fibroblast appears to be the primary source of myofibroblasts, other cells, including endothelial cells, can generate myofibroblasts through a process known as endothelial to mesenchymal transition (EndMT). During EndMT, endothelial cells lose their typical phenotype to acquire mesenchymal features, characterized by the development of invasive and migratory abilities as well as the expression of typical mesenchymal products such as α-smooth …

Differences In Cognitive Reflection Mediate Gender Differences In Social Preferences, Antonio M. Espín, Valerio Capraro, Brice Corgnet, Simon Gächter, Roberto Hernán-González, Praveen Kujal, Stephen Rassenti

ESI Working Papers

Previous studies have shown that women tend to be more egalitarian and less self-interested than men whereas men tend to be more concerned with social efficiency motives. The roots of such differences, however, remain unknown. Since different cognitive styles have also been associated with different distributional social preferences, we hypothesise that gender differences in social preferences can be partially explained by differences in cognitive styles (i.e., women rely more on intuition whereas men are more reflective). We test this hypothesis meta-analytically using data from seven studies conducted in four countries (USA, Spain, India, and UK; n=6,910) where cognitive reflection and …

Improving Patient-Specific Assessments Of Regional Aortic Mechanics Via Quantitative Magnetic Resonance Imaging With Early Applications In Patients At Elevated Risk For Thoracic Aortopathy, Patrick A. Jones

Theses and Dissertations

Unstable aortic aneurysms and dissections are serious cardiovascular conditions associated with high mortality. The current gold standards for assessment of stability, however, rely on simple geometric measurements, like cross-sectional area or increased diameter between follow-up scans, and fail to incorporate information about underlying aortic mechanics. Displacement encoding with stimulated echoes (DENSE) magnetic resonance imaging (MRI) has been used previously to determine heterogeneous circumferential strain patterns in the aortas of healthy volunteers. Here, I introduce technical improvements to DENSE aortic analysis and early pilot application in patients at higher risk for the development of aortopathies. Modifications to the DENSE aortic postprocessing …

Movement, Home Ranges, And Population Estimates Of Spotted Turtles (Clemmys Guttata) During A Rainy Breeding Season In Virginia, Lauren J. Jurczak

Theses and Dissertations

Spotted turtles (Clemmys guttata) use a complex of wetland and terrestrial habitats for survival and reproduction. Precipitation expands and creates larger and more numerous ephemeral pools available to spotted turtles on the landscape. In this study, I investigated the effects of precipitation on movement patterns and ephemeral pool usage by spotted turtles in southeastern Virginia. I conducted a 4-month capture-mark-recapture study alongside a telemetry study to estimate population size and to quantify movement of spotted turtles across the landscape during the breading season. A change point analysis was used to detect discrete changes in turtle behavior and whether …

Human Organic Anion Transporters 1 And 3: Structural Elements Impacting Transporter-Substrate Binding Interactions, Julie Nguyen

Theses and Dissertations

Organic anion transporters (OATs) are known to interact with a wide variety of negatively charged drugs and can impact their clinical safety and efficacy profiles. The U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMA) have recognized and highlighted the importance of evaluating the potential interactions with transporters, specifically hOAT1 and hOAT3, during the development of new drug entities. Little is known about OAT-drug interactions as they are difficult to discern on a molecular level in the absence of any solved crystal structures for OATs. Therefore, in a previous study, in silico homology models of hOAT1 and hOAT3 …

Modeling Vegetation Effects On Barrier Island Evolution, Eric W. Schoen

Theses and Dissertations

Barrier islands play a significant role in protecting coastlines and harboring coastal habitats. In an effort to study and better understand the evolution of barrier island systems, a cellular model capturing various meteorological and environmental processes is proposed. Erosion due to wind, gravity, and marine processes are coupled with plant population effects. We demonstrate the inhibition of plant cover on sediment mobility, island migration, and erosion in the presence of sea level rise.

Cloaca Palace, Connor Marie Stankard

Theses and Dissertations

In this thesis, I trace the compulsive fear of holes, known as trypophobia, from an uncontrollable obsession to a pleasurable preoccupation. The body’s physical porousness makes us receptive to our surroundings, allowing external matter in and destabilizing the boundaries of self and other. Matter invades us, encoding itself into our DNA and transforming humans into chimeric creatures.

Through paintings and multi-media installations, I encourage viewers to reflect on their own bodies as a series of holes, vulnerable receptors to the world. I use the figure of a woman to personify a human hole which has been infected by the outside, …

Heavy Hold: A Physical Score, Alexandra Velozo

Theses and Dissertations

This document is a collection of essays, stories, and fictional interviews that are in conversation with my performance, teaching, and sculpture practice. My research and work considers chronic illness, disability, the historic cultural connection between swamplands and illness, the medical industrial complex, medical theater, the medical gaze, disabled performers, metatactile space, sensory learning, and access.

Mechanistic Insights Of Mitochondrial Reactive Oxygen Species In Alzheimer's Disease Models, Jakob C. Green

Theses and Dissertations

Alzheimer’s disease (AD) is a neurodegenerative disease that results in impaired cognition, disorientation, confusion, poor judgement, and behavioral changes. The mitochondrial cascade hypothesis (MCH), which postulates that accumulating oxidative stress and mitochondrial dysfunction plays an integral role in the development of the disease, potentially upstream, in conjunction with or independent of Aβ and tau. The literature supports the critical role of mitochondrial dysfunction in the progression and development of AD, but is inconclusive about what precise role, as initiator or delegate, it performs. Regardless, the impact that oxidative stress and mitochondrial dysfunction have on AD deserves further study and investigation. …

Successional Changes In Carbon Storage Are Sustained In A Temperate Forest Across Different Initiating Disturbances, Cameron Clay

Theses and Dissertations

Managing forests for carbon (C) sequestration requires an understanding of how disturbance history shapes C pools and fluxes over successional time. At the University of Michigan Biological Station, we examined how two stand establishing disturbances influenced C pools and fluxes over 100+ years of succession, comparing these secondary forests with “legacy” late-successional stands encompassing ages and compositions that would be present in the absence of region-wide stand-replacing disturbance. Our work utilized measurements taken between 2014 and 2020 from separate experimental forest chronosequences initiated following clear-cut harvesting only or clear-cut harvesting and fire, along with three >130-yr-old late successional stands comprising …

Using Deep Learning-Based Framework For Child Speech Emotion Recognition, Gerald N. Onwujekwe

Theses and Dissertations

Biological languages of the body through which human emotion can be detected abound including heart rate, facial expressions, movement of the eyelids and dilation of the eyes, body postures, skin conductance, and even the speech we make. Speech emotion recognition research started some three decades ago, and the popular Interspeech Emotion Challenge has helped to propagate this research area. However, most speech recognition research is focused on adults and there is very little research on child speech. This dissertation is a description of the development and evaluation of a child speech emotion recognition framework. The higher-level components of the framework …

Local Delivery Of Tumor Associated Macrophage Immunotherapy For The Treatment Of Metastases To The Lungs, Sulaiman Alhudaithi

Theses and Dissertations

Metastases are the leading cause of cancer-related deaths, and the lungs are one of the primary sites of metastases from several malignancies. Existing therapies fail to entirely eradicate tumors that disseminate and reside in lungs; therefore, patient prognosis significantly worsens. Conventional therapies utilized to treat lung tumors such as chemotherapy are administered systemically and typically exhibit poor lung biodistribution profiles, leading to many undesirable off target effects and suboptimal drug concentration in the tumor, which may promote resistance, further compromising the quality of life of secondary lung cancer patients. Immune cells that infiltrate the tumor microenvironment (TME) play a central …

A Novel Sulfated Trimer Of Quercetin For Pulmonary Delivery To Treat The Emphysematous Lung, Abhinav Mohan

Theses and Dissertations

Emphysema, a major manifestation of chronic obstructive pulmonary disease (COPD), affects millions of patients in the United States; yet, no present treatment is able to directly modify the disease process. In the recent past, a pathobiologic hypothesis surrounding the deficiency of vascular endothelial growth factor (VEGF), has surfaced as a cause of the alveolar structural destruction and loss in emphysema. Additionally, sirtuin 1 (SIRT1), a regulator of anti-oxidative proteins and cellular homeostasis, has been found to be reduced in the lungs of emphysematous patients. Given these disturbances, this research hypothesized that such pathobiologic deficiencies can be inhibited with a sulfated …

The Mechanisms And Consequences Of Shrub Encroachment On The Virginia Barrier Islands, Lauren K. Wood

Theses and Dissertations

Shrub encroachment is a global phenomenon driven by direct and indirect anthropogenic influence which alters plant communities and ecosystem function. Many studies have investigated drivers and consequences of woody plant establishment, but mesic landscapes are underrepresented in the literature. My objective was to assess the mechanisms of Morella cerifera encroachment into coastal mesic grassland, the potential for self-reinforcement, and consequences on community composition, nutrients, and landscape productivity. I studied temperature and water microclimate modification by Morella cerifera presence and removal to understand ecosystem engineering and community composition changes. Additionally, I examined the influence of shrubs on surrounding grassland species traits …

E-Cigarette Use And Perceptions Among Adolescents With Attention-Deficit/Hyperactivity Disorder: The Role Of Parental Messages About Tobacco, Mayra S. Ramos

Theses and Dissertations

Adolescents with attention-deficit/hyperactivity disorder (ADHD) are at increased risk of using e-cigarettes compared to their neurotypical peers. Parent-adolescent communication about tobacco use and number of ADHD symptoms can influence adolescents’ perceptions of e-cigarettes and their e-cigarette use. Adolescents with ADHD (n = 80) completed questionnaires assessing parental messages about tobacco use; e-cigarette harm perceptions; susceptibility to use e-cigarettes; and e-cigarette use. Parents reported on messages about tobacco use, adolescent’s ADHD symptomatology, and completed demographic questionnaires. Twenty-percent of adolescents reported e-cigarette ever use. Adolescent girls were significantly more likely to report higher e-cigarette harm perceptions than boys. Parents reported providing messages …

A Computational Model Relating Tissue Oxygen Consumption To Oxygen Delivery In A Krogh Cylinder Model Of Skeletal Muscle, Raghad A. Alqahtani

Theses and Dissertations

Oxygen transport from a capillary to skeletal muscle tissue is a complex process that involves convective and diffusive mechanisms to deliver adequate oxygen to meet tissue metabolic activities. Typically, oxygen uptake in tissue is set by oxygen demand, which is set by metabolic activity. The relationship between the oxygen consumption (VO₂) of an isolated perfused tissue and the rate of delivery of oxygen (QO₂) to the tissue has been a subject of interest to many investigators over the past century. Experiments have shown that there is a critical value of QO₂ below which tissue VO …