Digital Commons Network^™

Peta V. Collins, District Of District Of Columbia

Historical and Topical Legal Documents

No abstract provided.

Is There A Role For Ct Pan-Scans In The Initial Work-Up Of Fragility Fracture Patients?, Eric Lepkowsky, Trevor Simcox, Hunter Rogoff, Shahidul Islam, Omid Barzideh

Stony Brook Orthopaedic and Musculoskeletal Journal

Background: CT pan-scans have become increasingly commonplace as part of the initial diagnostic work-up for patients sustaining traumatic injuries. They have proven effective in improving diagnostic accuracy in those with high energy mechanisms of injury. However, the utility of pan-scans in the geriatric population sustaining low energy traumatic injuries remains unproven. There is no study that assesses the usefulness of CT pan-scans in patients who sustain injuries related to osteoporosis, also known as fragility fractures.

Methods: A retrospective review was conducted of patients who sustained a fragility fracture at a Level 1 trauma center over a 15-month period. Patients underwent …

Covid-19 Reinfection With A Rare Variant Of Sars-Cov-2: The First Reported Case Of P.2 Variant In Alabama, Gabrielle Wilhelm, Ali Hassoun

UAB Huntsville Research Day - All Presentations

2021 clinical vignette poster

An Examination Of The Role Of Interpersonal Stressors And Attachment Style In Dissociative Experiences, Erin Verdi

Clinical Psychology Dissertations

Dissociation is an involuntary stress response that has been linked to negative cognitive, emotional, and physical symptoms. Interpersonal stressors are associated with negative mental and physical health outcomes above and beyond stressors that are not interpersonal in nature, and therefore may be relevant to dissociation. Additionally, attachment anxiety or avoidance (i.e., insecure attachment) may put individuals at risk for dissociation in response to social stressors and might moderate their responses. However, extant studies have yet to investigate the relationship between daily interpersonal stressors and dissociation in the context of attachment anxiety and avoidance longitudinally, despite evidence that dissociation and attachment …

Global Distribution, Host Range And Prevalence Of Trypanosoma Vivax: A Systematic Review And Meta-Analysis, Eyerusalem Fetene, Samson Leta, Fikru Regassa, Philippe Büscher

Harold W. Manter Laboratory of Parasitology: Library Materials

Background

Trypanosomosis caused by Trypanosoma vivax is one of the diseases threatening the health and productivity of livestock in Africa and Latin America. Trypanosoma vivax is mainly transmitted by tsetse fies; however, the parasite has also acquired the ability to be transmitted mechanically by hematophagous dipterans. Understanding its distribution, host range and prevalence is a key step in local and global efforts to control the disease.

Methods

The study was conducted according to the methodological recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. A systematic literature search was conducted on three search engines, namely PubMed, …

Human Body-Fluid Proteome: Quantitative Profiling And Computational Prediction, Lan Huang, Dan Shao, Yan Wang, Xueteng Cui, Yufei Li, Qian Chen, Juan Cui

School of Computing: Faculty Publications

Empowered by the advancement of high-throughput bio technologies, recent research on body-fluid proteomes has led to the discoveries of numerous novel disease biomarkers and therapeutic drugs. In the meantime, a tremendous progress in disclosing the body-f luid proteomes was made, resulting in a collection of over 15 000 different proteins detected in major human body fluids. However, common challenges remain with current proteomics technologies about how to effectively handle the large variety of protein modifications in those fluids. To this end, computational effort utilizing statistical and machine-learning approaches has shown early successes in identifying biomarker proteins in specific human diseases. …

Phenoimage: An Open-Source Graphical User Interface For Plant Image Analysis, Feiyu Zhu, Manny Saluja, Jaspinder Singh, Puneet Paul, Scott E. Sattler, Paul Staswick, Harkamal Walia, Hongfeng Yu

School of Computing: Faculty Publications

High-throughput genotyping coupled with molecular breeding approaches have dramatically accelerated crop improvement programs. More recently, improved plant phenotyping methods have led to a shift from manual measurements to automated platforms with increased scalability and resolution. Considerable effort has also gone into developing large-scale downstream processing of the imaging datasets derived from high-throughput phenotyping (HTP) platforms. However, most available tools require some programming skills.We developed PhenoImage, an open-source graphical user interface (GUI) based cross-platform solution for HTP image processing intending to make image analysis accessible to users with either little or no programming skills. The open-source nature provides the possibility …

Influence Of Irrigation Drivers Using Boosted Regression Trees: Kansas High Plains, Susan E. Lamb, Erin M.K. Haacker, Samuel J. Smidt

Department of Earth and Atmospheric Sciences: Faculty Publications

Groundwater levels across parts of western Kansas have been declining at unsustainable rates due to pumping for agricultural irrigation despite water-saving efforts. Accelerating this decline is the complex agricultural landscape, consisting of both categorical (e.g., management boundaries) and numerical (e.g., crop prices) factors that drive irrigation decisions, making integrated water budget management a challenge. Furthermore, these factors frequently change through time, rendering management strategies outdated within relatively short time scales. This study uses boosted regression trees to simultaneously analyze categorical and numerical data against annual irrigation pumping to determine the relative influence of each factor on groundwater pumping across both …

Targeted Metabolomics Analysis Of Postoperative Delirium, Bridget A. Tripp, Simon T. Dillon, Min Yuan, John M. Asara, Sarinnapha M. Vasunilashorn, Tamara G. Fong, Eran D. Metzger, Sharon K. Inouye, Zhongcong Xie, Long H. Ngo, Edward R. Marcantonio, Towia A. Libermann, Hasan H. Otu

Department of Electrical and Computer Engineering: Faculty Publications

Postoperative delirium is the most common complication among older adults undergoing major surgery. The pathophysiology of delirium is poorly understood, and no blood-based, predictive markers are available. We characterized the plasma metabolome of 52 delirium cases and 52 matched controls from the Successful Aging after Elective Surgery (SAGES) cohort (N= 560) of patients ≥ 70 years old without dementia undergoing scheduled major non-cardiac surgery. We applied targeted mass spectrometry with internal standards and pooled controls using a nested matched case-control study preoperatively (PREOP) and on postoperative day 2 (POD2) to identify potential delirium risk and disease markers. Univariate analyses identifed …

The Anisotropic Quasi-Static Permittivity Of Single-Crystal Β-Ga2O3 Measured By Terahertz Spectroscopy, Prashanth Gopalan, Sean Knight, Ashish Chanana, Megan Stokey, Praneeth Ranga, Michael A. Scarpulia, Sriram Krishnamoorthy, Vanya Darakchieva, Zbigniew Galazka, Klaus Irmscher, Andreas Fiedler, Steve Blair, Mathias Schubert, Berardi Sensale-Rodriguez

Department of Electrical and Computer Engineering: Faculty Publications

The quasi-static anisotropic permittivity parameters of electrically insulating beta gallium oxide (β-Ga₂O₃) were determined by terahertz spectroscopy. Polarization-resolved frequency domain spectroscopy in the spectral range from 200 GHz to 1 THz was carried out on bulk crystals along different orientations. Principal directions for permittivity were determined along crystallographic axes c and b and reciprocal lattice direction a*. No significant frequency dispersion in the real part of dielectric permittivity was observed in the measured spectral range. Our results are in excellent agreement with recent radio frequency capacitance measurements as well as with extrapolations from recent infrared measurements …

Honey Bee Foraged Pollen Reveals Temporal Changes In Pollen Protein Content And Changes In Forager Choice For Abundant Versus High Protein Flowers, Gabriela Quinlan, Meghan Milbrath, Clint Otto, Autumn Smart, Deborah D. Iwanowicz, Robert Cornman, Rufus Isaacs

Department of Entomology: Faculty Publications

Protein derived from pollen is an essential component of healthy bee diets. Protein content in honey bee foraged pollen varies temporally and spatially, but the drivers underlying this variation remain poorly characterized. We assessed the temporal and spatial variation in honey bee collected pollen in 12 Michigan apiaries over 3 summers (2015–2017). We simultaneously monitored forage in flowering habitats (uncultivated floristically-rich areas and conservation program land) near these apiaries throughout the growing season. We used these data, along with data from the literature on plant pollen protein content, to determine if honey bees collected a greater proportion of pollen from …

Challenges For Adoption Of Integrated Pest Management (Ipm): The Soybean Example, A. F. Bueno, A. R. Panizzi, Thomas E. Hunt, P. M. Dourado, R. M. Pitta, J. Gonçalves

Department of Entomology: Faculty Publications

Soybean is considered one of today’s most important crops. Planted on millions of hectares worldwide, the management of soybean pests usually requires large amounts of chemicals. However, a key component to meet the increasing demand for food due to the rapidly growing global population is protecting crops from pests while maintaining environmental quality through ecologically and economically sound integrated pest management (IPM) practices. Not only can IPM result in more profitable agriculture due to the reduction of pest control costs but also assures equitable, secure, sufficient, and stable flows of both food and ecosystem services. Despite those ecological and economic …

A First Flight In North Carolina—But Not At Kitty Hawk, Robert J. Wright

Department of Entomology: Faculty Publications

The southern corn billbug is a univoltine insect most common in the Coastal Plains region of North Carolina, Virginia, Georgia, and South Carolina. However, this insect can also be found in the midwestern U.S. (Van Duyn and Wright 1999). Early in the growing season, the adults can be found feeding at the base of corn plants—typically with their head pointed downward (Fig. 1)—by inserting their beak into the base of the plant. They can kill or stunt seedlings or injure the developing leaves inside the plant, causing twisted leaves as they emerge or a series of small holes across the …

Development And First Evaluation Of An Attractant Impregnated Adhesive Tape Against Blood-Sucking Flies, Junwei J. Zhu, Gwang-Hyun Roh, Yosuke Asamoto, Kujtim Bizati, Jen-Chieh Liu, Alexander Lehmann, Kyle Harrison, David B. Taylor, Hironao Otake

Department of Entomology: Faculty Publications

Stable flies are one of the most important arthropod pests of livestock that reduce cattle weight gain and milk production leading to annual economic losses in excess of $2 billion to the US cattle industry. The host-seeking behavior is primarily mediated by associated odors from stable fly larval development environments and host animals. The present paper reports the development and evaluation of attractant-impregnated adhesive tapes to reduce stable fly attacks on cattle. Laboratory bioassays showed that only m-cresol impregnated adhesive tapes caught significantly more stable flies (16 ± 1) than the control tape without attractant added (7 ± 1), with …

Patch Utilization And Flower Visitations By Wild Bees In A Honey Bee-Dominated, Grassland Landscape, Clint R. V. Otto, Larissa L. Bailey, Autumn H. Smart

Department of Entomology: Faculty Publications

Understanding habitat needs and patch utilization of wild and managed bees has been identified as a national research priority in the United States. We used occupancy models to investigate patterns of bee use across 1030 transects spanning a gradient of floral resource abundance and richness and distance from apiaries in the Prairie Pothole Region (PPR) of the United States. Estimates of transect use by honey bees were nearly 1.0 during our 3.5-month sampling period, suggesting honey bees were nearly ubiquitous across transects. Wild bees more frequently used transects with higher flower richness and more abundant flowers; however, the effect size …

Hitchhiking Or Hang Gliding? Dispersal Strategies Of Two Cereal-Feeding Eriophyoid Mite Species, Agnieszka Majer, Alicja Laska, Gary Hein, Lechosław Kuczyński, Anna Skoracka

Department of Entomology: Faculty Publications

Dispersal shapes the dynamics of populations, their genetic structure and species distribution; therefore, knowledge of an organisms’ dispersal abilities is crucial, especially in economically important and invasive species. In this study, we investigated dispersal strategies of two phytophagous eriophyoid mite species: Aceria tosichella (wheat curl mite, WCM) and Abacarus hystrix (cereal rust mite, CRM). Both species are obligatory plant parasites that infest cereals and are of economic significance. We investigated their dispersal success using different dispersal agents: wind and vectors. We hypothesised that in both mite species the main mode of dispersal is moving via wind, whereas phoretic dispersal is …

The Dynastine Scarab Beetles (Coleoptera: Scarabaeidae: Dynastinae) Of Chile, Brett C. Ratcliffe, Ronald D. Cave, José Mondaca

Department of Entomology: Faculty Publications

The eight species of dynastine scarab beetles that occur in Chile are reviewed. Keys, descriptions, geographic distributions, monthly adult activity, notes on natural history, illustrations, and distribution maps are provided for all species. The erroneous records of 16 dynastine species reported from Chile are reviewed and clarified. The monotypic genus Chiliphileurus Endrödi, 1977 is reduced to junior synonymy with Eophileurus Arrow, 1908, and its only species, Chiliphileurus tuberculatus Endrödi, 1977, follows as a new junior synonym of the Asian Eophileurus cingalensis Arrow, 1908.

A Comprehensive Review On Bioactive Peptides Derived From Milk And Milk Products Of Minor Dairy Species, Snigdha Guha, Heena Sharma, Gaurav Kr Deshwal, Priyanka Singh Rao

Department of Food Science and Technology: Faculty Publications

Milk from different species has been exploited for the isolation of various functional ingredients for decades. Irrespective of the source, milk is considered as a complete food, as it provides essential nutrients required by the human body. Proteins and their fractions are valuable sources of bioactive peptides that might exert a health beneficial role in the human body such as immune-modulation, antioxidant activity, ACE-inhibitory activity, anti- neoplastic, anti-microbial, etc. In milk, bioactive peptides may either be present in their natural form or released from their parental proteins due to enzymatic action. The increasing interest in bioactive peptides among researchers has …

Characterization Of Two Zygnema Strains (Zygnema Circumcarinatum Sag 698-1a And Sag 698-1b) And A Rapid Method To Estimate Nuclear Genome Size Of Zygnematophycean Green Algae, Xuehuan Feng, Andreas Holzinger, Charlotte Permann, Dirk Anderson, Yanbin Yin

Department of Food Science and Technology: Faculty Publications

Zygnematophyceae green algae (ZGA) have been shown to be the closest relatives of land plants. Three nuclear genomes (Spirogloea muscicola, Mesotaenium endlicherianum, and Penium margaritaceum) of ZGA have been recently published, and more genomes are underway. Here we analyzed two Zygnema circumcarinatum strains SAG 698-1a (mating +) and SAG 698-1b (mating −) and found distinct cell sizes and other morphological differences. The molecular identities of the two strains were further investigated by sequencing their 18S rRNA, psaA and rbcL genes. These marker genes of SAG 698-1a were surprisingly much more similar to Z. cylindricum (SAG 698-2) than to SAG 698-1b. …

Metabolic Profiling Of Historical And Modern Wheat Cultivars Using Proton Nuclear Magnetic Resonance Spectroscopy, Rachana Poudel, Fatema Bhinderwala, Martha Morton, Robert Powers, Devin J. Rose

Department of Food Science and Technology: Faculty Publications

To determine changes in the grain components between historical and modern wheat (Triticum aestivum L.) cultivars, wholemeal flours from 19 wheat cultivars and 2 landraces released or introduced between 1870 and 2013 and grown over two crop years were extracted using hydroalcoholic solution and analyzed using one dimensional 1H NMR spectral profiling. Grain yield, grain volume weight (GVW), and grain protein concentration were also measured. Grain yield increased while protein concentration decreased by release year (p < 0.001). Increasing trends (p < 0.01) were observed for tryptophan, sum of the measured amino acids, chlorogenic acid, ferulic acid, vanillic acid, and sum of the measured phenolic acids. Grain yield, phenolic acids, and tryptophan were mainly associated with modern cultivars, whereas grain protein concentration and GVW were associated with historical cultivars. The findings from this study showed changes in concentration of grain components over a century of breeding that may have implications for grain quality and human health.

Genome-Wide Identification And Comparative Analysis Of Arf Family Genes In Three Apiaceae Species, Qiaoying Pei, Nan Li, Qihang Yang, Tong Wu, Shuyan Feng, Xuehuan Feng, Zange Jing, Rong Zhou, Ke Gong, Tong Yu, Zhen Wang, Xiaoming Song

Department of Food Science and Technology: Faculty Publications

The family Apiaceae includes many important vegetables and medicinal plants. Auxin response factors (ARFs) play critical roles in regulating plant growth and development. Here, we performed a comprehensive analysis of the ARF gene family in three Apiaceae species, celery, coriander, and carrot, and compared the results with the ARF gene family of lettuce, Arabidopsis, and grape. We identified 156 ARF genes in all six species and 89 genes in the three Apiaceae species, including 28, 34, and 27 in celery, coriander, and carrot, respectively. The paralogous gene number in coriander was far greater than that in carrot and celery. Our …

Host Identity And Geographic Location Significantly Affect Gastrointestinal Microbial Richness And Diversity In Western Lowland Gorillas (Gorilla Gorilla Gorilla) Under Human Care, Katrina Eschweiler, Jonathan B. Clayton, Anneke Moresco, Erin A. Mckenney, Larry J. Minter, Mallory J. Suhr Van Haute, William Gasper, Shivdeep Singh Hayer, Lifeng Zhu, Kathryn Cooper, Kimberly Ange-Van Heugten

Department of Food Science and Technology: Faculty Publications

The last few decades have seen an outpouring of gastrointestinal (GI) microbiome studies across diverse host species. Studies have ranged from assessments of GI microbial richness and diversity to classification of novel microbial lineages. Assessments of the “normal” state of the GI microbiome composition across multiple host species has gained increasing importance for distinguishing healthy versus diseased states. This study aimed to determine baselines and trends over time to establish “typical” patterns of GI microbial richness and diversity, as well as interindividual variation, in three populations of western lowland gorillas (Gorilla gorilla gorilla) under human care at three …

Potential Applications Of Endo-B-N-Acetylglucosaminidases From Bifidobacterium Longum Subspecies Infantis In Designing Value-Added, Next-Generation Infant Formulas, Hatice Duman, Merve Kaplan, Aysenur Arslan, Arif Sercan Sahutoglu, Haci Mehmet Kayili, Steven A. Frese, Sercan Karav

Department of Food Science and Technology: Faculty Publications

Human milk is the optimal source of infant nutrition. Among many other health benefits, human milk can stimulate the development of a Bifidobacterium-rich microbiome through human milk oligosaccharides (HMOs). In recent years, the development of novel formulas has placed particular focus on incorporating some of the beneficial functional properties of human milk. These include adding specific glycans aimed to selectively stimulate the growth of Bifidobacterium. However, the bifidogenicity of human milk remains unparalleled. Dietary N-glycans are carbohydrate structures conjugated to a wide variety of glycoproteins. These glycans have a remarkable structural similarity to HMOs and, when released, show …

Bovine Colostrum And Its Potential For Human Health And Nutrition, Aysenur Arslan, Merve Kaplan, Hatice Duman, Ayse Bayraktar, Melih Ertürk, Bethany M. Henrick, Steven A. Frese, Sercan Karav

Department of Food Science and Technology: Faculty Publications

Colostrum is the first milk produced post-partum by mammals and is compositionally distinct from mature milk. Bovine colostrum has a long history of consumption by humans, and there have been a number of studies investigating its potential for applications in human nutrition and health. Extensive characterization of the constituent fractions has identified a wealth of potentially bioactive molecules, their potential for shaping neonatal development, and the potential for their application beyond the neonatal period. Proteins, fats, glycans, minerals, and vitamins are abundant in colostrum, and advances in dairy processing technologies have enabled the advancement of bovine colostrum from relative limitations …

Molecular Adaptation To Folivory And The Conservation Implications For Madagascar’S Lemurs, Elaine E. Guevara, Lydia K. Greene, Marina B. Blanco, Casey Farmer, Jeannin Ranaivonasy, Joelisoa Ratsirarson, Karine L. Mahefarisoa, Tsiky Rajaonarivelo, Hajanirina H. Rakotondrainibe, Randall E. Junge, Cathy V. Williams, Elodi Rambeloson, Hoby A. Rasoanaivo, Vololonirina Rahalinarivo, Laza H. Andrianandrianina, Jonathan B. Clayton, Ryan S. Rothman, Richard R. Lawler, Brenda J. Bradley, Anne D. Yoder

Department of Food Science and Technology: Faculty Publications

The lemurs of Madagascar include numerous species characterized by folivory across several families. Many extant lemuriform folivores exist in sympatry in Madagascar’s remaining forests. These species avoid feeding competition by adopting different dietary strategies within folivory, reflected in behavioral, morphological, and microbiota diversity across species. These conditions make lemurs an ideal study system for understanding adaptation to leaf-eating. Most folivorous lemurs are also highly endangered. The significance of folivory for conservation outlook is complex. Though generalist folivores may be relatively well equipped to survive habitat disturbance, specialist folivores occupying narrow dietary niches may be less resilient. Characterizing the genetic bases …

Heuristic And Hierarchical-Based Population Mining Of Salmonella Enterica Lineage I Pan-Genomes As A Platform To Enhance Food Safety, Joao Carlos Gomes-Neto, Natasha Pavlovikj, Carmen Cano, Baha Abdalhamid, Gabriel Asad Al-Ghalith, John Dustin Loy, Dan Knights, Peter C. Iwen, Byron D. Chaves, Andrew K. Benson

Department of Food Science and Technology: Faculty Publications

The recent incorporation of bacterial whole-genome sequencing (WGS) into Public Health laboratories has enhanced foodborne outbreak detection and source attribution. As a result, large volumes of publicly available datasets can be used to study the biology of foodborne pathogen populations at an unprecedented scale. To demonstrate the application of a heuristic and agnostic hierarchical population structure guided pan-genome enrichment analysis (PANGEA), we used populations of S. enterica lineage I to achieve two main objectives: (i) show how hierarchical population inquiry at different scales of resolution can enhance ecological and epidemiological inquiries; and (ii) identify population-specific inferable traits that could provide …

Prokevo: An Automated, Reproducible, And Scalable Framework For High-Throughput Bacterial Population Genomics Analyses, Natasha Pavlovikj, Joao Carlos Gomes-Neto, Jitender S. Deogun, Andrew K. Benson

Department of Food Science and Technology: Faculty Publications

Whole Genome Sequence (WGS) data from bacterial species is used for a variety of applications ranging from basic microbiological research, diagnostics, and epidemiological surveillance. The availability of WGS data from hundreds of thousands of individual isolates of individual microbial species poses a tremendous opportunity for discovery and hypothesis-generating research into ecology and evolution of these microorganisms. Flexibility, scalability, and user-friendliness of existing pipelines for population-scale inquiry, however, limit applications of systematic, population-scale approaches. Here, we present ProkEvo, an automated, scalable, reproducible, and open-source framework for bacterial population genomics analyses using WGS data. ProkEvo was specifically developed to achieve the following …

Interspecies Variation In Hominid Gut Microbiota Controls Host Gene Regulation, Amanda L. Muehlbauer, Allison L. Richards, Adnan Alazizi, Michael B. Burns, Andres Gomez, Jonathan B. Clayton, Klara Petrzelkova, Camilla Cascardo, Justyna Resztak, Xiaoquan Wen, Roger Pique-Regi, Francesca Luca, Ran Blekhman

Department of Food Science and Technology: Faculty Publications

The gut microbiome exhibits extreme compositional variation between hominid hosts. However, it is unclear how this variation impacts host physiology across species and whether this effect can be mediated through microbial regulation of host gene expression in interacting epithelial cells. Here, we characterize the transcriptional response of human colonic epithelial cells in vitro to live microbial communities extracted from humans, chimpanzees, gorillas, and orangutans. We find that most host genes exhibit a conserved response, whereby they respond similarly to the four hominid microbiomes. However, hundreds of host genes exhibit a divergent response, whereby they respond only to microbiomes from specific …

The International Scientific Association For Probiotics And Prebiotics (Isapp) Consensus Statement On Fermented Foods, Maria L. Marco, Mary Ellen Sanders, Michael Gänzle, Marie Claire Arrieta, Paul D. Cotter, Luc De Vuyst, Colin Hill, Wilhelm Holzapfel, Sarah Lebeer, Dan Merenstein, Gregor Reid, Benjamin E. Wolfe, Robert Hutkins

Department of Food Science and Technology: Faculty Publications

An expert panel was convened in September 2019 by The International Scientific Association for Probiotics and Prebiotics (ISAPP) to develop a definition for fermented foods and to describe their role in the human diet. Although these foods have been consumed for thousands of years, they are receiving increased attention among biologists, nutritionists, technologists, clinicians and consumers. Despite this interest, inconsistencies related to the use of the term ‘fermented’ led the panel to define fermented foods and beverages as “foods made through desired microbial growth and enzymatic conversions of food components”. This definition, encompassing the many varieties of fermented foods, is …

Dietary Fiber Intake, The Gut Microbiome, And Chronic Systemic Inflammation In A Cohort Of Adult Men, Wenjie Ma, Long H. Nguyen, Mingyang Song, Dong D. Wang, Eric A. Franzosa, Yin Cao, Amit Joshi, David A. Drew, Raaj Mehta, Kerry L. Ivey, Lisa L. Strate, Edward L. Giovannucci, Jacques Izard, Wendy Garrett, Eric B. Rimm, Curtis Huttenhower, Andrew T. Chan

Department of Food Science and Technology: Faculty Publications

Background: A higher intake of dietary fiber is associated with a decreased risk of chronic inflammatory diseases such as cardiovascular disease and inflammatory bowel disease. This may function in part due to abrogation of chronic systemic inflammation induced by factors such as dysbiotic gut communities. Data regarding the detailed influences of long-term and recent intake of differing dietary fiber sources on the human gut microbiome are lacking.

Methods: In a cohort of 307 generally healthy men, we examined gut microbiomes, profiled by shotgun metagenomic and metatranscriptomic sequencing, and long-term and recent dietary fiber intake in relation to plasma …