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2021

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Rapid And Efficient In Vitro Regeneration Of Transplastomic Potato (Solanum Tuberosum L.) Plants After Particle Bombardment, Md Jakir Hossain, Emre Aksoy, Zahi̇de Nesli̇han Öztürk Gökçe, Faiz Ahmad Joyia, Muhammad Sarwar Khan, Allah Bakhsh Jan 2021

Rapid And Efficient In Vitro Regeneration Of Transplastomic Potato (Solanum Tuberosum L.) Plants After Particle Bombardment, Md Jakir Hossain, Emre Aksoy, Zahi̇de Nesli̇han Öztürk Gökçe, Faiz Ahmad Joyia, Muhammad Sarwar Khan, Allah Bakhsh

Turkish Journal of Agriculture and Forestry

In contrast with traditional nuclear gene transformation, transplastomic technology has opened a new horizon for the transgenic plant research that offers several beneficial aspects including the convenient use of transgene stacking and the generation of high expression levels of foreign proteins. However, this technology has been well adopted and established in tobacco, the introduction and adoption of cost-effective, swift, and reproducible protocol for in vitro regeneration of transplastomic potato is challenging and laborious. The present research aimed to develop such prompt and efficient protocol to instigate and revive the regeneration potential with the combinations of different plant growth regulators (PGRs). …

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Stimulation Of Plant Secondary Metabolites Synthesis In Soilless Cultivated Strawberries (Fragaria × Ananassa Duchesne) Using Zinc-Alginate Microparticles, Slaven Juric, Kristina Vlahovicek-Kahlina, Boris Duralija, Luna Maslov Bandic, Petra Nekic, Marko Vincekovic Jan 2021

Stimulation Of Plant Secondary Metabolites Synthesis In Soilless Cultivated Strawberries (Fragaria × Ananassa Duchesne) Using Zinc-Alginate Microparticles, Slaven Juric, Kristina Vlahovicek-Kahlina, Boris Duralija, Luna Maslov Bandic, Petra Nekic, Marko Vincekovic

Turkish Journal of Agriculture and Forestry

An innovative approach to stimulate the production of plant secondary metabolites (PSM) is the use of encapsulated bioactive agents. Zinc-alginate microparticles [microspheres (ALG/Zn) and microcapsules (CS/ALG/Zn)] were applied near the root zone of soilless cultivated strawberries (Fragaria × ananassa Duchesne) to ensure a constant supply of an essential micronutrient zinc ions throughout the whole period of maturation. Both, ALG/Zn and CS/ALG/Zn had a positive effect on PSM (total polyphenols, total flavonoids, total anthocyanins, and flavan-3-ols) synthesis and increased antioxidant activity in two strawberry varieties (Albion and San Andreas). Treatments with Zn-alginate microparticles resulted in no visible damages on the plant …

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Identification And Expression Profiling Of Toxic Boron-Responsive Micrornas And Their Targets In Sensitive And Tolerant Wheat Cultivars, Doğa Seli̇n Kayihan, Emre Aksoy, Ceyhun Kayihan Jan 2021

Identification And Expression Profiling Of Toxic Boron-Responsive Micrornas And Their Targets In Sensitive And Tolerant Wheat Cultivars, Doğa Seli̇n Kayihan, Emre Aksoy, Ceyhun Kayihan

Turkish Journal of Agriculture and Forestry

Post transcriptional gene regulation in wheat cultivars caused by boron (B) toxicity has not been reported to date. In this study, two wheat cultivars Bolal-2973 (B-tolerant) and Atay-85 (B-sensitive) were compared with regard to the transcriptional regulation of miR319, miR172 and miR398 and their plausible target genes in order to address differences in their performances under high B levels. The expression levels of Cu/ZnSOD gene were found to be greater in Atay exposed to toxic B compared to Bolal, as verified by stable expression level of miR398. In wheat cultivars, both toxic B concentrations might cause an induction of leaf …

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Determination Of Fatty Acid And Tocopherol Contents In Chandler × Kaplan-86 F1 Walnut Population, Ümmühan Merve Arcan, Mehmet Sütyemez, Şaki̇r Burak Bükücü, Aki̇de Özcan, Muhammet Ali̇ Gündeşli̇, Sali̇h Kafkas, Nesi̇be Ebru Kafkas Jan 2021

Determination Of Fatty Acid And Tocopherol Contents In Chandler × Kaplan-86 F1 Walnut Population, Ümmühan Merve Arcan, Mehmet Sütyemez, Şaki̇r Burak Bükücü, Aki̇de Özcan, Muhammet Ali̇ Gündeşli̇, Sali̇h Kafkas, Nesi̇be Ebru Kafkas

Turkish Journal of Agriculture and Forestry

Walnut (Juglans regia L.) is one of the most common nuts in the world. There are a wide walnut variety of genotypes that differ in forestry, physical and chemical properties. Most of the walnut genotypes, which are natural resources have been evaluated as promising and germplasm sources for breeding. Walnuts are high in many beneficial biochemical compounds, so they have a useful profile for many people in relation to disease risk. Therefore, the demand for production and consumption of walnut is increasing day by day. In the present study, fatty acid and tocopherol profiles of 156 F1 genotypes belonging to …

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Evaluation Of Asparagus Adscendens Accessions For Root Yield And Shatavarin Iv Content In India, Parmeshwar Lal Saran, Susheel Singh, Vanrajsinh Solanki, Ravish Choudhary, Ponnuchamy Manivel Jan 2021

Evaluation Of Asparagus Adscendens Accessions For Root Yield And Shatavarin Iv Content In India, Parmeshwar Lal Saran, Susheel Singh, Vanrajsinh Solanki, Ravish Choudhary, Ponnuchamy Manivel

Turkish Journal of Agriculture and Forestry

The study was carried out to evaluate fifty-six accessions/species suitable for industrial purpose. Understanding the bioactive compound diversity among both the shatavari species, Asparagus racemosus (AR) and A. adscendens (AA) are an important species for crop development. Sufficient variation for bioactive compounds (shatavarin IV) were registered in both the species. AR and AA confined average 22.84 μg g-1 and 117.74 μg g-1 shatavarin IV, respectively. The A. adscendens produced about five-folds higher shatavarin IV content as compared to A. racemosus. Wide variation for shatavarin IV content were also observed within the AA accessions. Successful restoration of such species depends upon …

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Crosstalk Between Flowering And Cold Tolerance Genes In Almonds (Amygdalus Spp.), Başak Özdemi̇r, Fatma Yeşi̇m Okay, Gölge Sarikamiş, Canan Yüksel Özmen, Umut Ki̇bar, Ali̇ Ergül Jan 2021

Crosstalk Between Flowering And Cold Tolerance Genes In Almonds (Amygdalus Spp.), Başak Özdemi̇r, Fatma Yeşi̇m Okay, Gölge Sarikamiş, Canan Yüksel Özmen, Umut Ki̇bar, Ali̇ Ergül

Turkish Journal of Agriculture and Forestry

Almond production is usually affected by late spring frosts. Late flowering is an important trait in almond production in order to avoid frost damage. Breeding for late flowering has always been an important objective in almond breeding programs. Utilising molecular approaches may guide and accelerate breeding programs. In the present study, the expressions of the Prunus persica FLOWERING LOCUS T (PpFT) and Prunus armeniaca SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 (PabSOC1) genes known as floral integrators that promote flowering in plants were determined in almonds (Amygdalus spp.). Frost tolerance is another important trait in almond production. Almond accessions may vary in …

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Comparison Of Different Extraction Solvents Used In Gc-Ms Analysis For Detectingvolatile Odor Compounds In Heat Cow Sweat, Özgül Ani̇taş, Serap Göncü Jan 2021

Comparison Of Different Extraction Solvents Used In Gc-Ms Analysis For Detectingvolatile Odor Compounds In Heat Cow Sweat, Özgül Ani̇taş, Serap Göncü

Turkish Journal of Veterinary & Animal Sciences

The accurate estrus detection is essential for successful reproduction. Many scientists reported the importance of pheromones for accurate detection of estrus. In addition, the choice of the appropriate device and the appropriate extraction solvent is important for obtaining quickly and more estrus-specific pheromones. In this study, sweat samples were collected in heat cows and volatile organic compounds (VOCs) in the gas chromatography mass spectrometry were evaluated using three different solvents (diethyl ether, dichloromethane, and hexane) for extraction. VOCs with different numbers and different ratios were identified in all three extraction solvents. As the solvent, 9 compounds were detected in diethyl …

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Investigation Of The Zinc Accumulation In The Tissue And Performance In Broilers Raisedwith High Levels Of Zinc Sulfate Feed Under Heat Stress, Thawinan Waeothong, Jai Wei Lee, Liang Chou Hsia Jan 2021

Investigation Of The Zinc Accumulation In The Tissue And Performance In Broilers Raisedwith High Levels Of Zinc Sulfate Feed Under Heat Stress, Thawinan Waeothong, Jai Wei Lee, Liang Chou Hsia

Turkish Journal of Veterinary & Animal Sciences

The objectives of this study were to evaluate the effects of feeding zinc sulfate on the growth performance, Zn accumulation in the tissue, and the tibia quality. First day old of 100 chicks were randomly assigned to 10 experimental groups in a 5 (0 mg/kg Zn, 40 mg/kg ZnO, 40 mg/kg ZnSO$_{4}$.H$_{2}$O, 500 mg/kg ZnSO$_{}$, and 1000 mg/kg ZnSO$_{4}$) × 2 (high and low temperature) factorial arrangement under randomized complete block design (RCBD). Each experimental group was replicated with 10 birds. Birds were kept in individual cage until 42 days. The results showed that broilers receiving the zinc sulfate supplementation …

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Power Of Body Live Weights In Differentiation Physiological Growth Of Goat Breeds, Raed Alatiyat, Amani Al-Dawood Jan 2021

Power Of Body Live Weights In Differentiation Physiological Growth Of Goat Breeds, Raed Alatiyat, Amani Al-Dawood

Turkish Journal of Veterinary & Animal Sciences

We assumed that live body weight (LBW) would be useful to be utilized as informative categorical variable in differentiation goat performance towards better assignment into breeds. One-day old goat kids of both sexes were separately allocated as 3 breeds: Baladi, crossbreds and Shami. The kid LBW was recorded weekly until the 12th week of age. Weekly LBW showed a significant increase (p < 0.05) for both males and females of the 3 breeds and highly significant (p < 0.0001) between breeds. The high phenotypic correlation between most of the studied measurements encouraged us to investigate their efficiency in breed differentiation at early life age. Results showed that only LBW of the week 1, 2, 5, 9, and 11, and week 1, 2, 3, 11, and 12 were efficient in discriminating male and female kids, respectively. These results were better presented by showing significant genetic distances (p < 0.0001) between the breeds using the Unweighted Pair Group Method with Arithmetic mean (UPGMA) dendrogram. It is inferred that the phylogenetic tree lengths of the three breeds were 29.02 and 222.13 for male and female kids, respectively. Baladi and crossbred kids of both sexes grouped into one cluster closer than Shami kids. The canonical discriminant analysis was proved its successfulness for identifying breed based on LBW measurement.

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An Assessment Of Ensiling Potential In Maize X Legume (Soybean And Cowpea) Binarymixtures For Yield And Feeding Quality, Erdem Gülümser, Hani̇fe Mut, Uğur Başaran, Medi̇ne Çopur Doğrusöz Jan 2021

An Assessment Of Ensiling Potential In Maize X Legume (Soybean And Cowpea) Binarymixtures For Yield And Feeding Quality, Erdem Gülümser, Hani̇fe Mut, Uğur Başaran, Medi̇ne Çopur Doğrusöz

Turkish Journal of Veterinary & Animal Sciences

In this study, maize and legume intercropping were evaluated in terms of silage yield and quality. Maize (Zea mays L.''M'') was intercropped with soybean (Glycine max L. ''S'') and cowpea (Vigna unguiculata L. ''C'') as binary mixtues (maize + legume), and the seed rates were as follows: 100 + 0%, 75 + 25%, 50 + 50% and 25 + 75%. The harvested plants were chopped with the particle size of < 2, ensiled in 2 kg plastic jars and left fermentation at 25 ± 2 °C for 45 days. In this study, silage yield, dry matter ratio, pH value, crude protein ratio, acid detergent fiber, neutral detergent fiber, digestibility of dry matter, dry matter intake, total digestibil nutrient relative feed values, lactic acid, acetic acid, butyric acid, malic acid, citric acid, succinic acid, oxalic acid, potassium, phosphorus, calcium, and magnesium contents were determined. All the M + S mixtures showed high performance in terms of Flieg score and lactic acid content. The highest relative feed quality value was determined in the sole cowpea (156.4) and 25M + 75S% (148.5) mixture. As a result, intercropping maize with legumes resulted in superior silage quality without a reduction in yield.

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Investigation Of Relationships Between Placental Characteristics And Kid Birth Weight Ingoats, Çağri Kandemi̇r, Fatma Akkaya, Turğay Taşkin, Bi̇sem Ni̇sa Kandemi̇r Jan 2021

Investigation Of Relationships Between Placental Characteristics And Kid Birth Weight Ingoats, Çağri Kandemi̇r, Fatma Akkaya, Turğay Taşkin, Bi̇sem Ni̇sa Kandemi̇r

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to determine the relationships among the kid birth weight, the placental, and cotyledon traits in Saanen goats. The effect of parity, birth type, and birth weight (BIRWT), on placental and cotyledon characteristics, were analyzed by the general linear model. Significant differences for birth type occurred on cotyledon length (CL) and cotyledon depth (CDEP). The means for cotyledon width (CWID) and cotyledon depth (CDEP) were 21.52 and 0.361 mm, respectively. The general means of total cotyledon surface area (TCSA), cotyledon number (CN), and cotyledon weight (CWE) were 67.27 cm$^{2}$, 66.76 unit, and 153.51 g, respectively. …

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Variations In The Median Sacral Crest And Angulation Of The First Sacral Spinous Process Associated With Sacrocaudal Fusion In Greyhounds, Saad M. Y. Ismail, Christina M. Murray, Mark A. Stevenson, Hung-Hsun Yen, Helen M. S. Davies Jan 2021

Variations In The Median Sacral Crest And Angulation Of The First Sacral Spinous Process Associated With Sacrocaudal Fusion In Greyhounds, Saad M. Y. Ismail, Christina M. Murray, Mark A. Stevenson, Hung-Hsun Yen, Helen M. S. Davies

Turkish Journal of Veterinary & Animal Sciences

The current study aimed to investigate the association between the morphology of the median sacral crest, variation in the angle of the spinous process of the first sacral vertebra, and the occurrence of sacrocaudal fusion in greyhounds. In this study, 167 sacra from cadavers of greyhounds (previously euthanized for reasons unrelated to this study) were collected, classified into standard and fuses sacra (based on the number of fused vertebrae and type of fusion), and then classified based on the morphology of the median sacral crest into three different types: type F (full crest), type N (when the median sacral crest …

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Comparative Efficiency Of Five Mathematical Functions In Modelling The First Lactation Milk Yield Of Kankrej Cattle, Thiruvothur Venkatesan Raja, Achintya Kumar Das, Satish Kumar Rathee, Umesh Singh, Sushil Kumar, Bharat Singh Rathod, Harshad Panchasara Jan 2021

Comparative Efficiency Of Five Mathematical Functions In Modelling The First Lactation Milk Yield Of Kankrej Cattle, Thiruvothur Venkatesan Raja, Achintya Kumar Das, Satish Kumar Rathee, Umesh Singh, Sushil Kumar, Bharat Singh Rathod, Harshad Panchasara

Turkish Journal of Veterinary & Animal Sciences

Modelling of first lactation milk yield of Kankrej cattle was done using five different non-linear mathematical functions viz., exponential decline function (EDF), gamma function (GF), inverse polynomial function (IPF), mixed log function (MLF) and parabolic exponential function (PEF). We compared their efficiency in describing variations in first lactation milk yield of animals maintained under field conditions. A total of 3994 fortnightly daily milk records of 203 Kankrej cattle calved during the years between 2011 and 2017 at farmers? herds in the Banaskantha region of Gujarat State, India were utilized for the study. The PROC NLIN procedure of Statistical Analysis Software …

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Evaluation Of Cyp19 As A Candidate Gene For Milk Production Traits In Native Cattle Andbuffalo Populations Of Southern India, Sudhakar Krovvidi, Thiruvenkadan Kannan Aranganoor, Saravanan Ramasamy, Vinoo Regula, Muralidhar Metta, Jeyakumar Mani Jan 2021

Evaluation Of Cyp19 As A Candidate Gene For Milk Production Traits In Native Cattle Andbuffalo Populations Of Southern India, Sudhakar Krovvidi, Thiruvenkadan Kannan Aranganoor, Saravanan Ramasamy, Vinoo Regula, Muralidhar Metta, Jeyakumar Mani

Turkish Journal of Veterinary & Animal Sciences

Candidate gene approach facilitates searching causative polymorphisms that influence quantitative traits. Biosynthesis of estrogen catalyzed by aromatase, a product of the CYP19 gene affect lactogenesis. The objective of the study was to determine the polymorphism in the promoter region of CYP19 gene by PCR-RFLP and was undertaken on 502 bovine species belonging to Ongole (Bos indicus), Holstein Friesian crossbred, Jersey crossbred cattle, and Murrah buffaloes reared across Southern India. The frequency of the CYP19A allele was 0.90, 0.88, and 0.77 in Jersey crossbred, HF crossbred, and Ongole cattle, respectively. The BB genotypes could not be observed in Jersey crossbred cattle. …

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In Vitro Gas Production And Fatty Acids Biohydrogenation Of Diets Containing Different Unsaturated Fatty Acids Sources Plus Crude Glycerin, Arturo Samuel Gomez Insuasti, Yury Tatiana Granja-Salcedo, Julian Andres Castillo Vargas, Juliana Duarte Messana, Ana Paula De Oliveira Sader, Telma Teresinha Berchielli Jan 2021

In Vitro Gas Production And Fatty Acids Biohydrogenation Of Diets Containing Different Unsaturated Fatty Acids Sources Plus Crude Glycerin, Arturo Samuel Gomez Insuasti, Yury Tatiana Granja-Salcedo, Julian Andres Castillo Vargas, Juliana Duarte Messana, Ana Paula De Oliveira Sader, Telma Teresinha Berchielli

Turkish Journal of Veterinary & Animal Sciences

An in vitro trial was conducted to evaluate the effects of different unsaturated fatty acids (UFA) sources plus crude glycerin (CGL) on gas production and rumen biohydrogenation (RBH). Incubated diet corresponded to diets containing corn silage (30%) and concentrate (70%) composed of corn, urea, mineral salts, CGL, and different UFA sources as follows: no additional fat (NAF), rumen protected fat (RPF), soybean oil, linoleic acid (LA) or alpha-linolenic acid (LN). Methane concentrations in LA and LN were lower compared to NAF (p < 0.001), but when CH4 was expressed as a proportion of total gas, NAF and RPF showed the greatest values among evaluated UFA sources (p = 0.001). 18:1 t11 concentration showed a faster increase from 0 to 1 h and a slower decrease from 1 to 36 h of incubation, irrespective of UFA source. A higher C18:1 t11 production rate was observed from 1 h to 5 h of incubation, where LA and LN have higher values compared to NAF and RPF diets (p < 0.001). Diets with a high content of LA may be efficient as a nutritional approach to reduce methane production and RBH, resulting in positive effects on vaccenic acid concentrations.

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Risk Of Tuberculosis Is Increased In Behçet's Disease Compared To Other Rheumatologicaldisorders After Anti-Tnf∝ Treatments: A Case Series And Review Of The Literature, Ümmügülsüm Gazel, Derya Kocakaya, İrem Hi̇cret Topçu, Hakan Ömer Karataş, Murat Karabacak, Mehmet Pami̇r Atagündüz, Güzi̇de Nevsun İnanç, Fatma Ali̇baz Öner, Rafi̇ Haner Di̇reskeneli̇ Jan 2021

Risk Of Tuberculosis Is Increased In Behçet's Disease Compared To Other Rheumatologicaldisorders After Anti-Tnf∝ Treatments: A Case Series And Review Of The Literature, Ümmügülsüm Gazel, Derya Kocakaya, İrem Hi̇cret Topçu, Hakan Ömer Karataş, Murat Karabacak, Mehmet Pami̇r Atagündüz, Güzi̇de Nevsun İnanç, Fatma Ali̇baz Öner, Rafi̇ Haner Di̇reskeneli̇

Turkish Journal of Medical Sciences

Background/aim: Tumor necrosis factor-alfa (TNF-a) antagonists are extensively utilized in the treatment of inflammatory rheumatic diseases and also shown to be effective in Behçet's disease (BD) patients with major organ involvement. In this study, we aimed to reevaluate the incidence of tuberculosis (TB) infection after anti-TNFa treatments and to reveal the risk of TB in BD. Methods: Data of patients who received anti-TNFa treatment between 2005 and 2018 were assessed retrospectively. Demographic features, TNF-a antagonist type/treatment time, tuberculosis skin test (TST) and QuantiFERON results, isoniazid prophylaxis status, and concomitant corticosteroid (CS) treatments were collected. Results: A total of 1277 (male/female …

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Circulating Mir-29c-3p Is Downregulated In Patients With Acromegaly, Hakan Korkmaz, Kuyaş Heki̇mler Öztürk, Bora Torus Jan 2021

Circulating Mir-29c-3p Is Downregulated In Patients With Acromegaly, Hakan Korkmaz, Kuyaş Heki̇mler Öztürk, Bora Torus

Turkish Journal of Medical Sciences

Background/aim: miRNAs control various biological functions, such as cell proliferation, differentiation, signaling pathways, apoptosis and metabolism. Recently, it has been shown that there is a relationship between changes in miRNA expression and the development of acromegaly. Studies are needed to identify new disease-specific miRNAs. The aim of the current study is to evaluate plasma miR-29c-3p, miR-31-5p and miR-18a-5p steady-state levels in acromegaly. Another aim is to investigate whether there is a difference in the levels of these miRNAs in patients with inadequate control and controlled acromegaly with somatostatin analog (SSA) therapy. These miRNAs targeting the IGF-1 gene were determined by …

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Allergic Reactions Against Covıd-19 Vaccines, Hi̇lal Ünsal, Bülent Eni̇s Şekerel, Ümi̇t Murat Şahi̇ner Jan 2021

Allergic Reactions Against Covıd-19 Vaccines, Hi̇lal Ünsal, Bülent Eni̇s Şekerel, Ümi̇t Murat Şahi̇ner

Turkish Journal of Medical Sciences

Coronavirus Disease 2019 (COVID-19) affected the whole world in a short time. One of the most influential public health initiatives modern medicine has to offer, the vaccine has become even more important as the COVID-19 pandemic continues to worsen worldwide. Many vaccine trials were launched during the COVID-19 pandemic, and these vaccines were widely used around the world, offering realistic hope for ending the pandemic. Allergic reactions to vaccines were reported shortly after their approval. These reactions, in general, are rare, but, in some circumstances, they can be serious. Allergy to vaccines can occur because of either the active vaccine …

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Are The Criteria Always Right? Assessment Of Hepatocellular Carcinoma Cases In Livingdonor Liver Transplantation At A High-Volume Center, Yücel Yankol, Gülteki̇n Hoş, Turan Kanmaz, Nesi̇mi̇ Meci̇t, Yilmaz Çakaloğlu, Münci̇ Kalayoğlu, Koray Sadik Acarli Jan 2021

Are The Criteria Always Right? Assessment Of Hepatocellular Carcinoma Cases In Livingdonor Liver Transplantation At A High-Volume Center, Yücel Yankol, Gülteki̇n Hoş, Turan Kanmaz, Nesi̇mi̇ Meci̇t, Yilmaz Çakaloğlu, Münci̇ Kalayoğlu, Koray Sadik Acarli

Turkish Journal of Medical Sciences

Background/aim: With the increased experience in living donor liver transplantation (LDLT), it has been adopted for the treatment of hepatocellular carcinoma (HCC), with emerging discussions of criteria beyond tumor size and number. In contrast to deceased donor liver transplantation (DDLT), recipient selection for LDLT is not limited by organ allocation systems. We discuss herein the assessment, criteria, and experience with liver transplantation (LT) in HCC cases at a high-volume LDLT center. Material and methods: Between August 2006 and December 2017, 191 adult LT HCC recipients with at least one-year follow-up were retrospectively analyzed. Results: In 191 patients, one-, three- and …

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Activation-Induced Cytidine Deaminase Expression In Patients With Myelodysplasticsyndrome And Its Relationship With Prognosis And Treatment, Ege Si̇nan Torun, Aynur Aday, Meli̇ha Nalçaci Jan 2021

Activation-Induced Cytidine Deaminase Expression In Patients With Myelodysplasticsyndrome And Its Relationship With Prognosis And Treatment, Ege Si̇nan Torun, Aynur Aday, Meli̇ha Nalçaci

Turkish Journal of Medical Sciences

Background/aim: Activation-induced cytidine deaminase (AID) enables antibody diversity in B lymphocytes. It may also have an effect on MDS pathogenesis by causing somatic mutations and by inducing epigenetic changes in myeloid cells. This study aimed to compare AID expression of MDS patients with healthy controls, of MDS patients in different risk groups, and of MDS patients according to their treatment. Materials and methods: Total RNA was isolated and complementary DNA (cDNA) was transcribed from the peripheral blood samples of MDS patients and healthy controls. AID and the reference gene HPRT1 were analyzed using quantitative real-time PCR (QRT-PCR). AID expression relative …

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Assessment Of Erythrocyte Morphology In Patients With Type 2 Diabetes Mellitus: A Pilotstudy Of Electron Microscopy-Based Analysis In Relation To Healthy Controls, Tülay Mortaş, Şenay Arikan Durmaz, Şaban Cem Sezen, Yasemi̇n Savranlar Jan 2021

Assessment Of Erythrocyte Morphology In Patients With Type 2 Diabetes Mellitus: A Pilotstudy Of Electron Microscopy-Based Analysis In Relation To Healthy Controls, Tülay Mortaş, Şenay Arikan Durmaz, Şaban Cem Sezen, Yasemi̇n Savranlar

Turkish Journal of Medical Sciences

Background/aim: The present study aimed to assess erythrocyte morphology in newly diagnosed type 2 diabetes mellitus patients using scanning electron microscopy. Materials and methods: In total, 30 patients admitted to endocrine outpatient clinics were included in the study. The patients were divided into two groups according to their fasting blood glucose levels: type 2 diabetes mellitus (n = 15, fasting blood glucose levels ≥ 126 mg/dL) and control (n = 15, fasting blood glucose levels < 99 mg/dL). The patient's demographic characteristics, haemoglobin A1c levels, and scanning electron microscopy findings regarding erythrocyte morphology were recorded. Results: There was no significant difference between the control and type 2 diabetes mellitus group in terms of the participants' age (51.13 ± 8.53 vs. 50.33 ± 8.72 years, p = 0.8) and the male/female ratio (9/6 vs. 9/6). In the control group, discocytes were abundant, echinocytes were rare, and spherocytes were absent. On the other hand, discocytes were less common and echinocyte-shaped erythrocytes were more common in the type 2 diabetes mellitus group than in the control group. In addition, spherocytes were detected in the type 2 diabetes mellitus group. Moreover, the diameter of discocytes was significantly lower (p = 0.014), and blood glucose and haemoglobin A1c levels were significantly higher (p < 0.05 for both) in the type 2 diabetes mellitus group than in the control group. Conclusion: Our findings indicate that high glucose levels in type 2 diabetes mellitus patients lead to significant alterations in erythrocyte morphology, including decreased erythrocyte deformability and the formation of echinocytes and spherocytes due to eryptosis. The possibility of decreased erythrocyte deformability due to excessive eryptosis may disturb microcirculation in newly diagnosed, treatment-naïve type 2 diabetes mellitus patients who do not have any complications.

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High Mobility Group Box-1 Levels May Be Associated With Disease Activity Of Behcet's Disease, Di̇lara Dönmez Güler, Ayşe Bahar Keleşoğlu Di̇nçer, Zeynep Ceren Karahan, Hasan Seli̇m Güler, Müçteba Enes Yayla, Serdar Sezer, Emi̇ne Gözde Aydemi̇r Gülöksüz, İlyas Ercan Okatan, Murat Torğutalp, Di̇dem Şahi̇n Eroğlu, Mehmet Levent Yüksel, Tahsi̇n Murat Turğay, Gülay Kinikli, Aşkin Ateş Jan 2021

High Mobility Group Box-1 Levels May Be Associated With Disease Activity Of Behcet's Disease, Di̇lara Dönmez Güler, Ayşe Bahar Keleşoğlu Di̇nçer, Zeynep Ceren Karahan, Hasan Seli̇m Güler, Müçteba Enes Yayla, Serdar Sezer, Emi̇ne Gözde Aydemi̇r Gülöksüz, İlyas Ercan Okatan, Murat Torğutalp, Di̇dem Şahi̇n Eroğlu, Mehmet Levent Yüksel, Tahsi̇n Murat Turğay, Gülay Kinikli, Aşkin Ateş

Turkish Journal of Medical Sciences

Background/aim: High mobility group box- 1 (HMGB- 1) is a nuclear protein acting as a proinflammatory molecule. The serum HMGB- 1 levels were found elevated in chronic inflammatory diseases. In this cross-sectional study, serum HMGB- 1 levels in Behcet's disease (BD) patients and healthy controls (HC) were studied. Also, its association with disease activity scores and clinical findings were evaluated. Materials and methods: Ninety BD patients and 50 age-sex matched HC were included in the study. Disease activity scores were assessed by Behcet Disease Current Activity Form (BDCAF) and Behcet Syndrome Activity Score (BSAS). Serum HMGB- 1 levels were measured …

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Impact Of Low Molecular Weight Heparin Administration On The Clinical Course Of Thecovid-19 Disease, Burcu Yormaz, Di̇lek Ergün, Baykal Tülek, Recai̇ Ergün, Uğur Arslan, Fi̇kret Kanat Jan 2021

Impact Of Low Molecular Weight Heparin Administration On The Clinical Course Of Thecovid-19 Disease, Burcu Yormaz, Di̇lek Ergün, Baykal Tülek, Recai̇ Ergün, Uğur Arslan, Fi̇kret Kanat

Turkish Journal of Medical Sciences

Background: Lymphopenia is the most important criterion of mortality and discharging feature for patients infected with coronavirus disease 2019 (COVID-19). This study aimed to investigate the clinical impact of a low molecular weight heparin (LMWH) treatment on the clinical course of COVID-19. Materials and methods: Patients' clinical symptoms, radiologic outcomes, hematologic, biochemical, D-dimer, and C-reactive protein (CRP) results were obtained from their medical records. Participants were separated into 2 groups: one was treated with LMWH and the other was not. Improvement in the patients was compared before and after treatment. Results: Ninety-six patients who were diagnosed with COVID-19 between April …

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Imaging Modalities Used In Diagnosis And Follow-Up Of Patients With Takayasu's Arteritis, Ayşe Bahar Keleşoğlu Di̇nçer, Levent Kiliç, Abdulsamet Erden, Umut Kalyoncu, Tuncay Hazirolan, Sedat Ki̇raz, Ömer Karadağ Jan 2021

Imaging Modalities Used In Diagnosis And Follow-Up Of Patients With Takayasu's Arteritis, Ayşe Bahar Keleşoğlu Di̇nçer, Levent Kiliç, Abdulsamet Erden, Umut Kalyoncu, Tuncay Hazirolan, Sedat Ki̇raz, Ömer Karadağ

Turkish Journal of Medical Sciences

Background/aim: Takayasu's arteritis (TA) is a rare, large-vessel vasculitis of unknown etiology, affecting aortic arch, and its main branches. Noninvasive imaging methods are frequently used in diagnosis and follow-up in Takayasu's arteritis. Studies investigating optimal timing of follow up imaging are rare. This study is aimed to investigate the radiologic changes in vascular involvements of Takayasu's arteritis patients one year after diagnosis. Materials and methods: Database of our Vasculitis Center was analyzed retrospectively and 97 patients were included into the study. Demographic, clinical, radiological, and therapeutic findings of patients were recorded. Patients with follow-up imaging after approximately one year of …

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Does Fludrocortisone Treatment Cause Hypomagnesemia In Children With Primaryadrenal Insufficiency?, İbrahi̇m Mert Erbaş, Selda Ayça Altincik, Gönül Çatli, Tolga Ünüvar, Bayram Özhan, Ayhan Abaci, Ahmet Anik Jan 2021

Does Fludrocortisone Treatment Cause Hypomagnesemia In Children With Primaryadrenal Insufficiency?, İbrahi̇m Mert Erbaş, Selda Ayça Altincik, Gönül Çatli, Tolga Ünüvar, Bayram Özhan, Ayhan Abaci, Ahmet Anik

Turkish Journal of Medical Sciences

Background/aim: Aldosterone is a mineralocorticoid that secreted from adrenal glands and a known factor to increase magnesium excretion by direct and indirect effects on renal tubular cells. Although the frequency of hypomagnesemia was found to be approximately 5% in adult studies, there is no study in the literature investigating the frequency of hypomagnesemia in children by using fludrocortisone, which has a mineralocorticoid activity. Materials and methods: A multi-center retrospective study was conducted, including children who were under fludrocortisone treatment for primary adrenal insufficiency and applied to participant pediatric endocrinology outpatient clinics. Results: Forty-three patients (58.1% male, 41.9% prepubertal) included in …

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The Prognostic Value Of Serum Levels Of A Proliferation-Inducing Ligand (April) Intreatment-Naïve Patients With Chronic Lymphocytic Leukemia, Si̇nem Ni̇hal Esatoğlu, Di̇lek Keski̇n, Ahmet Emre Eşkazan, Tuğrul Elverdi̇, Ayşe Sali̇hoğlu, Muhli̇s Cem Ar, Şeni̇z Öngören, Zafer Başlar, Yildiz Aydin, Hafi̇ze Uzun, Teoman Soysal Jan 2021

The Prognostic Value Of Serum Levels Of A Proliferation-Inducing Ligand (April) Intreatment-Naïve Patients With Chronic Lymphocytic Leukemia, Si̇nem Ni̇hal Esatoğlu, Di̇lek Keski̇n, Ahmet Emre Eşkazan, Tuğrul Elverdi̇, Ayşe Sali̇hoğlu, Muhli̇s Cem Ar, Şeni̇z Öngören, Zafer Başlar, Yildiz Aydin, Hafi̇ze Uzun, Teoman Soysal

Turkish Journal of Medical Sciences

Background/aim: A proliferation-inducing ligand (APRIL) has been investigated as a prognostic marker in chronic lymphocytic leukemia (CLL) patients. However, there is no cut-off level for serum APRIL (sAPRIL) levels that predict time to treatment in CLL patients. Materials and methods: Between May and December 2012, 94 consecutive CLL patients and 25 healthy controls were assessed. sAPRIL levels were measured by ELISA. Demographic data and prognostic markers were obtained from the patients' files. Treatment-naïve patients were followed up for 6.5 years for any treatment need. Results: Patients were divided into 3 groups: Treatment-naïve (n = 47), chemotherapy receiving (n = 25), …

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Assessment Of St2 And Reg3a Levels In Patients With Acute Graft-Versus-Host Disease Afterallogeneic Hematopoietic Stem Cell Transplantation, Eli̇fcan Aladağ Karakulak, Haluk Demi̇roğlu, Ümi̇t Yavuz Malkan, Ümi̇t Akman, Hakan Göker, Yahya Büyükaşik Jan 2021

Assessment Of St2 And Reg3a Levels In Patients With Acute Graft-Versus-Host Disease Afterallogeneic Hematopoietic Stem Cell Transplantation, Eli̇fcan Aladağ Karakulak, Haluk Demi̇roğlu, Ümi̇t Yavuz Malkan, Ümi̇t Akman, Hakan Göker, Yahya Büyükaşik

Turkish Journal of Medical Sciences

Background/aim: Graft-versus-host disease (GVHD) is a crucial complication leading to significant morbidity and mortality allogeneic hematopoietic stem cell transplantation which occurs in approximately half of the transplant recipients. Suppression of tumorigenicity 2 (ST2) and regenerating islet-derived 3-alpha(Reg3a) might be important biomarkers to predict acute GVHD. Materials and methods: In the present study, blood samples were collected from 17 patients with acute GVHD and 12 control patients after allogeneic stem cell transplantation. ST2 and Reg3a were measured in plasma samples compared in patients with acute GVHD and the controls. Results: Median age of the study population was 42 years (range 19-49). …

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Stereological And Histopathological Evaluation Of The Effect Of Thymoquinone Onperidural Fibrosis Following Laminectomy In Rats, Dursun Türköz, Aytaç Türköz, Mehmet Emi̇n Önger, Eni̇s Kuruoğlu Jan 2021

Stereological And Histopathological Evaluation Of The Effect Of Thymoquinone Onperidural Fibrosis Following Laminectomy In Rats, Dursun Türköz, Aytaç Türköz, Mehmet Emi̇n Önger, Eni̇s Kuruoğlu

Turkish Journal of Medical Sciences

Background/aim: This study's aim was to investigate the effects of thymoquinone, which is the essential bioactive component of the volatile oil of Nigella sativa on the peridural fibrosis in rats following laminectomy. Materials and methods: Twenty female Wistar Albino rats were used in our study. The rats were randomly divided into 2 groups: Sham and Surgery + Thymoquinone. Both groups underwent laminectomy at L1 under general anesthesia. The Sham group was not subjected to any drug application. The 2nd group was treated with intraperitoneal 10-mg/kg thymoquinone once per day for a period of 28 days, following the same surgical procedure. …

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An Ecological Comparison Between Resource Subsidies: Pacific Lamprey (Entosphenus Tridentatus) And Pacific Salmon (Oncorhynchus Spp.), Jocelyn Wensloff Jan 2021

An Ecological Comparison Between Resource Subsidies: Pacific Lamprey (Entosphenus Tridentatus) And Pacific Salmon (Oncorhynchus Spp.), Jocelyn Wensloff

All Master's Theses

Historically, oligotrophic Pacific Northwest (PNW) streams received annual returns of spawning anadromous fish that provided resource subsidies in the form of marine-derived nutrients (MDN), thus driving stream food web productivity. To date, many studies in the PNW have focused on Pacific salmon (Oncorhynchus spp.) as a resource subsidy, overlooking other anadromous fish species such as Pacific lamprey (Entosphenus tridentatus). Both Pacific salmon and Pacific lamprey are culturally important to PNW tribes for ceremonial, medicinal, and subsistence purposes, and have been since time immemorial. Unfortunately, both salmon and lamprey populations are in decline. Historically, lamprey have been disregarded …

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Cold-Induced Metabolic Changes In Lean, Nag-1 Transgenic Mice, Rachel J. Davey Jan 2021

Cold-Induced Metabolic Changes In Lean, Nag-1 Transgenic Mice, Rachel J. Davey

All Master's Theses

Obesity is a multifaceted metabolic disorder with severe worldwide public health consequences. While obesity can often be treated using diet and exercise, there are complex genetic interactions driving obesity that don’t always respond to such changes. One important research focus for addressing genetic factors is activating brown adipose tissue which increases thermogenesis, the process of burning stored fats to generate heat. Cold exposure is a known way to activate brown adipose tissue through b3-adrenergic signaling. This signaling pathway causes an upregulation of thermogenesis in brown adipocytes and beige adipocytes, which is white adipose tissue that “browns” and becomes metabolically active. …

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