Digital Commons Network^™

Liger-Hn Phase Iii Trials Of Petosemtamab + Pembrolizumab And Petosemtamab Monotherapy In Recurrent Or Metastatic Hnscc, Jean-Pascal Machiels, Douglas Adkins, Et Al.

2020-Current year OA Pubs

Patients with recurrent/metastatic (r/m) head and neck squamous cell carcinoma (HNSCC) have limited treatment options and a dismal prognosis, especially when their cancer is resistant to standard treatments like anti-programmed cell death protein 1 and platinum-based therapies. Petosemtamab - a human, common light chain, bispecific antibody with enhanced antibody-dependent cellular cytotoxicity targeting epidermal growth factor receptor (EGFR) and leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) - demonstrated antitumor activity in r/m HNSCC. In many tumor types, including HNSCC, EGFR is an oncogenic driver, while LGR5 is upregulated. LGR5 can potentiate the wingless-type integration site (WNT)/β-catenin signaling pathway in response to …

Mayo Normative Studies: Regression-Based Normative Data For Remote Self-Administration Of The Stricker Learning Span, Symbols Test, And Mayo Test Drive Screening Battery Composite And Validation In Individuals With Mild Cognitive Impairment And Dementia, Nikki H Stricker, Jason Hassenstab, Et Al.

2020-Current year OA Pubs

No abstract provided.

Projection-Tags Enable Multiplex Projection Tracing And Multi-Modal Profiling Of Projection Neurons, Lite Yang, Fang Liu, Hannah Hahm, Takao Okuda, Xiaoyue Li, Yufen Zhang, Vani Kalyanaraman, Monique R Heitmeier, Vijay K Samineni

2020-Current year OA Pubs

Single-cell multiomic techniques have sparked immense interest in developing a comprehensive multi-modal map of diverse neuronal cell types and their brain-wide projections. However, investigating the complex wiring diagram, spatial organization, transcriptional, and epigenetic landscapes of brain-wide projection neurons is hampered by the lack of efficient and easily adoptable tools. Here we introduce Projection-TAGs, a retrograde AAV platform that allows multiplex tagging of projection neurons using RNA barcodes. By using Projection-TAGs, we performed multiplex projection tracing of the cortex and high-throughput single-cell profiling of the transcriptional and epigenetic landscapes of the cortical projection neurons in female mice. Projection-TAGs can be leveraged …

Cell-Free Protein Synthesis Reactor Formats: A Brief History And Analysis, Dallin M. Chipman, Anna C. Woolley, Davu N. Chau, William A. Lance, Joseph P. Talley, Tyler P. Green, Benjamin C. Robbins, Bradley Charles Bundy

Faculty Publications

Cell-free protein synthesis (CFPS) has transformed protein production capabilities by eliminating cellular constraints, enabling the rapid expression of difficult-to-produce proteins in an open, customizable environment. As CFPS applications expand from fundamental research to industrial production, therapeutic manufacturing, and point-of-care diagnostics, the diverse array of reactor formats has become increasingly important yet challenging to navigate. This review examines the evolution and characteristics of thirteen major CFPS reactor formats, from traditional batch systems to advanced platforms. The historical development of CFPS reactors from the 1960s to present day is presented. Additionally, for each format, operational principles, advantages, limitations, and notable applications are …

Why The “Whole Language Approach” To Reading Fails Ell Students & Instructional Strategies To Employ Instead, Caitlyn E. Petrus

Journal of English Learner Education

The research presented in this article demonstrates a qualitative view of the science of reading for phonemic awareness instruction, phonics instruction, vocabulary development, and reading comprehension strategies for English Language Learners (ELLs) in PK-12 schools. The research builds upon esteemed writers Dr. Sharon Vaughn and Dr. Sylvia Linan-Thompson’s work in their book Research-Based Methods of Reading Instruction for Learners, Grades K-4 and other reading experts such as Dr. Wiley Blevins and Dr. Lisa Moats to apply to the growing population for ELLs in PK-12 schools and how to shift from a “whole language classroom” to a classroom built on the …

Extractivism And Water Crisis In The Moroccan Draa Oasis: Global South Reflections On Responsibility And Resistance, Ahmed El Khatabi

Journal of Maya Heritage

Abstract. The Draa Oasis in southeastern Morocco is experiencing severe water scarcity, driven by climate change and intensified by the expansion of watermelon agribusiness and desert tourism. This article explores how external investors, empowered by national agricultural policies, have disrupted traditional water governance systems rooted in collective management. Through ethnographic fieldwork involving interviews, focus groups, and spatial mapping, the study examines the socio-environmental consequences of groundwater depletion and land commodification. It argues that investors fail to assume ethical accountability for the ecological degradation they cause, despite being aware of the oasis’s fragile ecosystem. Meanwhile, local communities and civil society actors …

"Access Granted": Analyzing The Growing Use Of Biometric Data Collection At Sports Facilities, Patrick Doll

UNH Sports Law Review

No abstract provided.

Comparison Of Energy Efficiency And Vegetation In Different Establishment And Management Systems Of Steep Mountainous Grassland In The Aso Area, Japan, K Kabata, C Okamoto, M Shimizu, M Kikuchi

IGC Proceedings (1977-2023)

The Aso area is one of the most important areas for grass­land agriculture in Japan. In this area there exists ca. 44,000 hectares of which ca. 28,700 ha are steep mountainous lands ( a gradient of more than 15 degrees). Additionally, there is much precipitation (ca 2.600 mm/year) in the area. Consequently, there is a problem of grassland destruction due to soil erosion. Therefore, in order to promote the utilization and conser­vation of steep grasslands, the following two experimental grazing were carried out: 1) a two pasture system and 2) a coexistent pasture system with introduced and native grasses. In …

Comparison De La Dynamique De La Vegetation De Deux Ecosystemes Herbagers Mesoxerophiles Apres Deprise Agricole Dans Le Massif Vosgien, S Muller

IGC Proceedings (1977-2023)

Les orientations actuelles de !'agriculture europeenne dans le cadre de la Politique Agricole Commune de la Communaute Economique Europeenne devraient conduire a !'abandon dans les decennies a venir de plusieurs millions d'hectares de terres agricoles en France, entrainant des modifications ecologiques et paysageres considerables. Dans le Massif Vosgien la deprise agricole, consecutive a la regression des industries traditionnelles et a !'elevation du niveau de vie, a provoque !'abandon depuis les annees 1950 de nombreux herbages, autrefois entretenus surtout par des pluri­actifs. Ces milieux evoluent alors vers des friches herbacees seboisant plus ou moins rapidement de maniere spontanee.

Massif Vosgien constitue …

Le Role Des Plantes Herbageres Dans La Limitation Des Pertes Des Principaux Elements Nutritifs Par Le Drainage, S Kopec

IGC Proceedings (1977-2023)

Depuis longtemps on connait !'action anti-erosive des plan­tes herbageres qui empechent d'une fa< ;on tres efficace l'affais­sement des particules de sol, en particulier sur des surfaces en pente. Dans ces derniers temps on parle de plus en plus souvent du role des herbages dans la limitation du drainage des elements nutritifs du sol et de nombreuses recherches menees a cet effet dans plusieurs pays le confirment (Jones, 1972; Gachon et Tri­boi, 1967; Kopec, 1985). Dans cette etude on a presente les resultats des recherches lysimetriques Sur la quantite des principaux elements nutritifs draines par les eaux s'evacuant des terrains agricoles couverts d'herbages et d'autres cultures.

Degradation Models And Their Use In Determining The Condition Of Southern African Grasslands, O.J H. Bosch, K Kellner, S.H E. Scheepers

IGC Proceedings (1977-2023)

An understanding of the processes of change is an important prerequisite for the development of techniques for the monitor­ing of condition and trend, and to interpret the ecological sig­nificance of determined condition classes. The approach to develop and use degradation models for determining range condition is illustrated in this paper by means of basic ecological data from the relatively high rainfall zone in the climatic climax grasslands (Mentis and Huntley, 1982) of southern Africa.

An Experiment And Study On A Air-Seeding Astragalus Adsurgens For Soil Conservation On The Loess Plateau Of China, Yimin Liang, Daiqiong Li, Xinhai Cong

IGC Proceedings (1977-2023)

The irrational land utilization has resulted in destruction of original vegetation and serious soil erosion on the Loess Pla­teau in China. At present, 1600 million ton of sediment is disch­arged into the Yell ow River per year. In order to explore effec­tive avenues to speed reestablishing vegetation for controlling soil erosion, we made an experiment in seeding forage and shrubs by airplane for four years, from 1976 to 1979, in semi­arid region on the Loess Plateau. We selected suitable plant species for aerial seeding on semiarid region, determined fit aerial seeding time and seeding rate through manual broadcast and air-seeding. …

Role Potentiel Des Legumineuses Annuelles A Ressemis En France, P Masson, G Gintzburger

IGC Proceedings (1977-2023)

L'interet pour les legumineuses annuelles a ressemis est recent en France malgre !'importance de la zone mediterra­neenne et atlantique dont ces plantes sont originaires. Le trefle souterrain (Trifolium subterraneum) et les luzernes annuelles (Medicago sp.) apparaissent respectivement dans notre littera­ture specialisee a la suite de travaux d'amelioration pastorate en Corse (Etienne, 1977) et des travaux de plusieurs labora­toires de l'Institut National de la Recherche Agronomique a Montpellier (Gintzburger et Prosperi, 1987). Apres 4 ans d'experimentation dans diverses situations des Pyrenees Orientates dans le sud de la France en climat mediter­raneen (pluviometrie moyenne annuelle de 575 mm a …

Agroforestry In The Southeastern United States, H A. Pearson, C E. Lewis

IGC Proceedings (1977-2023)

Agroforestry has been practiced for many years in the tropics by intermixing forages under palms, fruit trees, or hardwoods. Interest has increased in temperate zones for combining trees, pastures, crops, and livestock. Agroforestry in the United States is generally limited to the combining of pines, tame pastures, and cattle. Our purpose is to summarize results of research and developments in the southeastern United States on cool-and warm-season forages under planted pines and pine regeneration in tame pasture.

The Effects Of Heavy Metals Applied In Digested Sewage Sludge To Grassland, A Desira Buttigieg, D A. Klessa, D A. Hall

IGC Proceedings (1977-2023)

The application of potentially toxic elements in sewage sludge to grassland has implications to environmental pol­lution and the health of grazing rumiµants. In Scotland, mod­erately acid grassland receives most of the sewage sludge applied to agricultural land and there is therefore a risk of heavy metal mobilisation and uptake by herbage. In addition, soil ingestion (Fleming, 1986) and intake of herbage contami­nated with sludge adhering to leaf surfaces may present an important means by which potentially toxic elements are absorbed by ruminants. In this paper, two aspects of sewage sludge use on grassland are studied, namely : 1. Factors affecting …

Increasing Flora Diversity In Grassland Swards, R J. Haggar, D Jones

IGC Proceedings (1977-2023)

Europe's farmers are being encouraged to take land out of agriculture in order to reduce surplus cereal production. There is therefore, increasing scope for creating new species-rich swards, although guidelines for this purpose are lacking. Several reasons are advanced for encouraging species diver­sity and conservation, including recreational, ethical, education and resource utilisation. As leisure time increases, so public interest in conservation matters increases. Scientifically, there is a need to preserve genetic diversity and to understand the com­plex plant and animal relationship leading to a rich and varied community. This paper describes two experiments aimed at achieving a . highly diverse …

Grass Plan Density For Adequate Conservation Reserve Program Stands, D W. Meyer, D Rugroden

IGC Proceedings (1977-2023)

The Conservation Reserve Program (CRP), a federal program with the objective to reduce surplus feed grain pro­duction in the United States by idling marginal cropland, has already idled nearly 12 million hectares with a target of 32 mil­lion hectares. Idled land must be seeded to perennial grasses to help prevent soil erosion. The required grass seeding has caused the cost of grass seed to increase several fold ; therefore, estab­lishment cost could be reduced considerably if seeding rates could be reduced from the present recommended 215 to 323 seeds/m2 (Dodds, 1981). Recommended seeding rates were developed from research on establishment …

Multiple Of The Intermountain Region, Forest Service, United States Department Of Agriculture, J S. Tixier, A H. Winward

IGC Proceedings (1977-2023)

Initial custodians of the National Forests of the United States were primarily concerned about protecting what were perceived as deteriorating timber stands and watersheds. Con­siderable progress was made in correcting these problems in the first half of this Century. As the population of the United States grew, more people became interested in management of all resources on these public lands. Forest Officers gradually became stewards managing a broad array of lands and resources for which there were often conflicting interests and uses. A primary use of National Forests in the Western United States has been livestock grazing. Here, animals are …

Phosphatic Settling Pond Clays As Potential Forage Legume Seed Production Site, D D. Baltensperger, G M. Prine, D S. Wofford

IGC Proceedings (1977-2023)

Forage legume species perform a vital role in the agriculture of the state of Florida (Baltensperger et al., 1985a, 1985b, and 1987; Taylord et al., 1985). Cool-season cultivars adapted to this climate must also perform well in the Pacific Northwest or California since these are the primary areas of commercial seed production (Baltensperger et al., 1987). Commercial seed for the wa:m��s_eason species is typically produced in Florida. A pri­mary hm1tmg factor for seed production in Florida is the low water-holding-capacity of the sandy soils which necessitates frequent irrigation, subsequently reducing seed quality. Potential seed production areas include reclaimed phosphate minelands …

Influence Of Reduced Intensity Of Grassland Management On Herbage Yield, Forage Quality, Sod Density And Botanical Composition, P Dahmen, W Kuhbauch, U Thome

IGC Proceedings (1977-2023)

In the Federal State of Northrhine Westfalia, a number of programs have been initiated to reduce intensity of land use with respect to unwanted environmental effects presumably coming from conventional agricultural systems. On grassland most of the programs require delayed first cuttings for hay and silage, reduced fertilization and/or less grazing pressure on pastures. Field experiments were established in order to evalu­ate consequences of these programs for practical farming and grassland ecology. Treatments include conventional grassland management systems with intensive fertilization and utilization as well as intermediate and low intensity systems.

Limits For Cattle Slurry Application On Permanent Grassland, B Stratmann, W Kuhbauch

IGC Proceedings (1977-2023)

Several experiments indicate little risk of groundwater pol­lution with nitrate under permanent grass (DVWK 1985), but only few studies deal with surface water contamination due to grassland fertilization, especially slurry spreading. The purpose of this work was to determine the effect of cattle slurry in comparison to mineral nitrogen fertilization on surface run-off and interflow quality under different inclinated permanent grassland (18 % and 4.5 % resp.).

Effects Of Incorporation Of Organic Material And/Or Limestone On Grasses Grown On Acid Coal Refuse, B D. Gardner, She-Kong Chong, F J. Olsen

IGC Proceedings (1977-2023)

Disposal of coal preparation wastes is a serious environmen­tal problem. Waste materials whose particle size is less than 2 mm are classified as slurry. About 67 000 hectares in the U.S.A. are affected by surface disposal of coal mining wastes. These materials tend to be acid, draughty and possess high surface temperatures thus retarding natural succession on affected sites. Regulations require that slurry impoundments be covered with 120 cm of non-toxic material and revegetated. The cost of such treatment can exceed $ 24,000 per hectare (Kosowski, 1973). Brundage (1974) and Sukthumrong (1975) concluded that alternate, less expensive methods could be …

On The Resource Of Chinese White Clover (Trifolium Repens L.), Zhu Bangchang

IGC Proceedings (1977-2023)

China is one of the countries in the world rich in legume. According to the research of Dr Sun-xingdong, the late herbalist, among the Chinese local genera Trifolium, there are white clover (Trifolium repens L. ), and so on; all of them number about more than ten species. White clover has a specially important place in the herbage resource in every province of South China. Chinese white clover is distributed mainly over the range of 22°-51° north latitude, 80°-130° east longitude. The range of optimal temperature for white clover is l9°-24°C, but under -15°C (minimum temperature) in winter, it …

Nutritional Quality Of Subterranean Clover Cultivars In West Central Spain, B Garcia-Criado, A Garcia-Ciudad, M Rico-Rodriguez, L Garcia-Criado

IGC Proceedings (1977-2023)

The nutritional quality of 61 subterranean clover (Trifolium subterraneum L.) cultivars was studied, during 1982, in the province of Salamanca (semiarid zone of west central Spain). Plant samples were collected at the late-bloom stage and were analyzed for protein, carbohydrates and digestibility. The levels of all these constituents fluctuated within acceptable ranges. Higher relative variability was observed in respect of hemicellulose, protein and lignin, while the digestibility values presented lower relative variability. The latter ranged from 71.1 to 76.1 % with a mean of 73.3%, while protein values ranged from 11.1 to 19.4% with a mean of 14.0%. Chemical …

Influence Of Diverse Harvest Schedules On Evaluation Of Birdsfoot Trefoil Cultivar Compared To Alfalfa, C C. Sheaffer, G C. Marten

IGC Proceedings (1977-2023)

Birdsfoot trefoil (Lotus corniculatus; BFf) cultivars, including the recently released 'Noreen', have not been adequately evaluated for their response to a diversity of harvest managements. Our objective was to determine the effect of three harvest schedules on forage yield, forage quality, and stand persistence of BFf cultivars and an adapted cultivar of alfalfa (Medicago sativa). 'Empire', 'Viking', 'Maitland', 'Carroll', 'Leo', and Noreen BFf and 'Ramsey' alfalfa were established in monocultures and in binary timothy mixtures (Phleum pratense). Stockpile (two harvests), recommended hay (three harvests), and simulated pasture (four harvests) schedules were applied for 3 years. Noreen …

Evaluation Of Miyakogusa (Lotus Corniculatus L. Var. Japonicus Regel): Population Distributed In Japan, S Saiga, K Suginobu, Shinji Suzuki

IGC Proceedings (1977-2023)

Twenty-one Miyakogusa populations collected from all over Japan were evaluated with 3 birdsfoot trefoil cul ti vars at four different locations between 1982 and 1984. Generally, Miyakogusa showed poor spring vigor, more prostrate type, lower plant height, fewer stems, earlier flowering, less winter hardiness and poor fall vigor. These populations were classified into 5 groups using Principal Component Analysis (PCA) and Cluster Analysis. As the results of PCA plant type, maturity and winter hardiness are mainly extracted for the first, second and third principal component, respectively. Populations belonging to group V and IV, having high scores of the first component …

Identifying Winter Hardy Alfalfa (Medicago Sativa) For Northwestern Canada, J S. Mckenzie, G E. Mclean

IGC Proceedings (1977-2023)

Winter kill is one of the most serious problems affecting alfalfa production in northwestern Canada. A rapid and accurate means of assessing winter hardiness is invaluable in developing new cultivars for this region. This program was designed to define some plant and environmental factors responsible for winter injury and to develop tests to identify plants with high yield potential and resistance to severe winter stress in northwestern Canada. The program has determined that the cold hardiness of alfalfa can change from year to year depending upon the plant and/or environmental conditions during the growing season. Three factors have been identified …

Fringed Sagebrush, Ming Chang Wang

IGC Proceedings (1977-2023)

Fringed sagebruch (Artemisia frigida will) is one of the common plants in inner mongolia plateau. It was recognized as an excellent perennial herbaceous plants accunting for a large proportion in wild vegetation. Fringed sagebruch belongs to composites, Semi-frutex, tomentellate in whole plant, tap root may be 100 cm deep in the soil. Fringed sagebrush distributed to the north of the Yellow River in China, Fareast and Caucasus in USSR, Mongolia and Canada. Fringed sagebruch is an excellent forage for horses, cattle, sheep, goats and Camels. The animals will get gain if fringed sagebruch is fed.

Morphological Variation In Prairie Grass, M J. Hill, A C. Kirby

IGC Proceedings (1977-2023)

Prairie grass (Bromus catharticus Yahl) is a little used pasture species in Australia. However, the availability of Grasslands Matua from New Zealand has prompted renewed interest in the plant. Low tillering capacity is a major limitation on good performance of prairie grass in pastures (Hill and Pearson 1985). A comparison of the morphology of Australian commercial lines with a world collection was carried out to define the available variation in agronomically important morphological characters, and Matua was compared with an Australian line at two cutting frequencies and two temperatures during spring and summer. Two morphological groups were distinguished by …

The Performance Of Grass And Legume Species Under Irrigation In Southern Italy, A Corleto, L Magini

IGC Proceedings (1977-2023)

Performance data over a 3 year period are presented for several varieties belonging to grass and legume species were compared in 2 separate randomized block design under cutting in an irrigated flat area of Southern Italy (Segezia, Apulia, altitude 74 m). Among grass highest D .M. Y. was produced by varieties belonging to Phalaris tuberosa, Festuca arundinacea, Brom us catharticus, Dactylis glomerata and one variety (Asso) of Loli um multiflorum. Among legume, varieties of Medicago sativa furnished highest D.M.Y. that outyielded best grasses. The earliest growth has been exhibited by Lolium multiflorum (cv. Asso), Festuca arundinacea (cv. Maris Jebel), Phalaris …