Digital Commons Network^™

Context-Responsive Equitable Strategies For Developing Gender-Responsive Curriculums In Nepal, Parbati Dhungana Ms, Roshani Rajbanshi, Lina Gurung

Transformations

We argue that context-responsive equitable strategies support the development of a gender-responsive curriculum in the context of higher education in Nepal. This paper is our reflective journey of curriculum content analysis of the two Master’s programs (Mathematics and English) from an inclusive cultural perspective of gender which engaged us to explore the answer to the question- How can we develop a gender-responsive curriculum? Adapting inclusive cultural perspective and participatory design we engaged with students and faculties and management representatives in the process of gender mainstreaming through action-reflection cycles. Further, we braided discussion with poetry, that is, a poetic inquiry to …

The Unconstitutionality Of State Bans On Marriage Between First Cousins, Rachel Frommer

Cardozo Law Review de•novo

A majority of jurisdictions in the United States severely limit or prohibit the right of first cousins to marry, cohabit, or have intercourse. Yet, unlike regulation of other relationships within close degrees of consanguinity, for instance between parents and children or siblings, these statutes are relatively recent additions to the marriage regulation landscape. These bans are unsupported by the commonly-cited concerns of harmful genetic or societal consequences. First cousin-marriages are, instead, popular and permitted in much of the world—as they once were in the United States. This Article demonstrates that the prohibitions against first-cousin marriages directly contravene right-to-marry jurisprudence and …

Annual Report Of The Registrar 2020/2021, University Of Northern Iowa

Institutional Effectiveness & Planning Documents

Contents:

--- Definitions
--- Some Comparisons
--- Annual Report Data
--- Summary of Attendance
--- Attendance by Session
--- Degrees Granted 2020/21
--- Degree Summary 2020/21
--- Program Certificates 2020/21
--- Miscellaneous Enrollment Information
--- Degrees Granted by College, Degree and Racial/Ethnic Classification

Impact Of Covid-19 On Older Adults In Rural Alabama, Kris Warf

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

That Code-Switching Switchgrass - A Root Analysis Of Two Ecotypes Of P. Virgatum Under Temperture Variations, Hannah Johnson

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Mammalian Nuclear Trub1, Mitochondrial Trub2, And Cytoplasmic Pus10 Produce Conserved Pseudouridine 55 In Different Sets Of Trna., Shaoni Mukhopadhyay, Manisha Deogharia, Ramesh Gupta

Articles

Most mammalian cytoplasmic tRNAs contain ribothymidine (T) and pseudouridine (Ψ) at positions 54 and 55, respectively. However, some tRNAs contain Ψ at both positions. Several Ψ54-containing tRNAs function as primers in retroviral DNA synthesis. The Ψ54 of these tRNAs is produced by PUS10, which can also synthesize Ψ55. Two other enzymes, TRUB1 and TRUB2, can also produce Ψ55. By nearest-neighbor analyses of tRNAs treated with recombinant proteins and subcellular extracts of wild-type and specific Ψ55 synthase knockdown cells, we determined that while TRUB1, PUS10, and TRUB2 all have tRNA Ψ55 synthase activities, they have different tRNA structural requirements. Moreover, these …

Eye-Tracking As A Window Into Assembled Phonology In Native And Non-Native Reading, Katherine I. Martin, Alan Juffs

Articles

The past 30 years of reading research has confirmed the importance of bottom-up processing. Rather than a psycholinguistic guessing game (Goodman, 1967), reading is dependent on rapid, accurate recognition of written forms. In fluent first language (L1) readers, this is seen in the automatic activation of a word’s phonological form, impacting lexical processing (Perfetti & Bell, 1991; Rayner, Sereno, Lesch & Pollatsek, 1995). Although the influence of phonological form is well established, less clear is the extent to which readers are sensitive to the possible pronunciations of a word (Lesch & Pollatsek, 1998), …

Chemical Synthesis Of Peptidoglycan Mimetic–Disaccharide-Tetrapeptide Conjugate And Its Hydrolysis By Bacteriophage T5, Rb43 And Rb49 L-Alanyl-D-Glutamate Peptidases, Viatcheslav Azev, Alexey Chulin, Maxim Molchanov, Dmitry Prokhorov, Galina Mikoulinskaia, Vladimir N. Uversky, Viktor Kutyshenko

Molecular Medicine Faculty Publications

Endolysins of a number of bacteriophages, including coliphages T5, RB43, and RB49, target the peptidoglycans of the bacterial cell wall. The backbone of these bacterial peptidoglycans consist of alternating N-acetylglucosamine and N-acetylmuramic acid residues that is further “reinforced” by the peptide subunits. Because of the mesh-like structure and insolubility of peptidoglycans, the processes of the peptidoglycan binding and hydrolysis by enzymes cannot be studied by spectral methods. To overcome these issues we synthesized and analyzed here one of the simplest water soluble peptidoglycan mimetics.

A compound has been synthesized that mimics the peptidoglycan fragment of the bacterial cell wall, N-acetylglucosaminyl-β(1-4)-N-acetylmuramoyl-l-alanyl-γ-d-glutamyl-l-alanyl-d-alanine. …

Structural Protein Analysis Of Driver Gene Mutations In Conjunctival Melanoma, Mak B. Djulbegovic, Vladimir N. Uversky, J. William Harbour, Anat Galor, Carol L. Karp

Molecular Medicine Faculty Publications

In recent years, there has been tremendous enthusiasm with respect to detailing the genetic basis of many neoplasms, including conjunctival melanoma (CM). We aim to analyze five proteins associated with CM, namely BRAF, NRAS, c-KIT, NF1, and PTEN. We evaluated each protein for its intrinsically disordered protein regions (IDPRs) and its protein-protein interactions (PPI) with the Predictor of Natural Disordered Protein Regions (PONDR®) and the Search Tool for the Retrieval of Interacting Genes (STRING®). Our PONDR® analysis found high levels of IDPRs in all five proteins with mutations linked to CM. The highest levels of IDPRs were in BRAF (45.95%), …

On The Roles Of Intrinsically Disordered Proteins And Regions In Cell Communication And Signaling, Sarah E. Bondos, A. Keith Dunker, Vladimir N. Uversky

Molecular Medicine Faculty Publications

For proteins, the sequence → structure → function paradigm applies primarily to enzymes, transmembrane proteins, and signaling domains. This paradigm is not universal, but rather, in addition to structured proteins, intrinsically disordered proteins and regions (IDPs and IDRs) also carry out crucial biological functions. For these proteins, the sequence → IDP/IDR ensemble → function paradigm applies primarily to signaling and regulatory proteins and regions. Often, in order to carry out function, IDPs or IDRs cooperatively interact, either intra- or inter-molecularly, with structured proteins or other IDPs or intermolecularly with nucleic acids. In this IDP/IDR thematic collection published in Cell Communication …

Predicting Associations Of Mirnas And Candidate Gastric Cancer Genes For Nanomedicine, Aigul Akimniyazova, Anna Pyrkova, Vladimir N. Uversky, Anatoliy Ivashchenko

Molecular Medicine Faculty Publications

Nanoscale miRNAs regulate the synthesis of most human proteins involved in differentiation, proliferation, cell cycle, apoptosis, and other processes associated with the growth and the development of an organism. miRNAs also play a number of important roles in the development of gastric cancer. In this work, we studied the quantitative characteristics of miRNA interactions with 69 candidate gastric cancer genes using bioinformatics approaches. To this end, the MirTarget program was used, which determines the characteristics of miRNA binding to mRNA in the 5′UTR, CDS, and 3′UTR. Associations of miRNAs with alternative target genes and associations of genes with alternative miRNAs …

Protein Intrinsic Disorder And Evolvability Of Mers-Cov, Vladimir N. Uversky, Elrashdy M. Redwan, Abdullah A. Aljadawi

Molecular Medicine Faculty Publications

No abstract provided.

Evolutionary Signatures Governing The Codon Usage Bias In Coronaviruses And Their Implications For Viruses Infecting Various Bat Species, Naveen Kumar, Rahul Kaushik, Chandana Tennakoon, Vladimir N. Uversky, Anamika Mishra, Richa Sood, Pratiksha Srivastava, Meghna Tripathi, Kam Y. J. Zhang, Sandeep Bhatia

Molecular Medicine Faculty Publications

Many viruses that cause serious diseases in humans and animals, including the betacoronaviruses (beta-CoVs), such as SARS-CoV, MERS-CoV, and the recently identified SARS-CoV-2, have natural reservoirs in bats. Because these viruses rely entirely on the host cellular machinery for survival, their evolution is likely to be guided by the link between the codon usage of the virus and that of its host. As a result, specific cellular microenvironments of the diverse hosts and/or host tissues imprint peculiar molecular signatures in virus genomes. Our study is aimed at deciphering some of these signatures. Using a variety of genetic methods we demonstrated …

Analysis Of The Dark Proteome Of Chandipura Virus Reveals Maximum Propensity For Intrinsic Disorder In Phosphoprotein, Nishi R. Sharma, Kundlik Gadhave, Prateek Kumar, Mohammad Saif, Md. M. Khan, Debi P. Sarkar, Vladimir N. Uversky, Rajanish Giri

Molecular Medicine Faculty Publications

Chandipura virus (CHPV, a member of the Rhabdoviridae family) is an emerging pathogen that causes rapidly progressing influenza-like illness and acute encephalitis often leading to coma and death of the human host. Given several CHPV outbreaks in Indian sub-continent, recurring sporadic cases, neurological manifestation, and high mortality rate of this infection, CHPV is gaining global attention. The ‘dark proteome’ includes the whole proteome with special emphasis on intrinsically disordered proteins (IDP) and IDP regions (IDPR), which are proteins or protein regions that lack unique (or ordered) three-dimensional structures within the cellular milieu. These proteins/regions, however, play a number of vital …

Covid-19 Vaccines And Thrombosis—Roadblock Or Dead-End Street?, Kenneth Lundstrom, Debmalya Barh, Bruce D. Uhal, Kazuo Takayama, Alaa A. A. Aljabali, Tarek Mohamed Abd El-Aziz, Amos Lal, Elrashdy M. Redwan, Parise Adadi, Gaurav Chauhan, Samendra P. Sherchan, Gajendra Kumar Azad, Nima Rezaei, Ángel Serrano-Aroca, Nicolas G. Bazan, Sk. Sarif Hassan, Pritam Kumar Panda, Pabitra Pal Choudhury, Damiano Pizzol, Ramesh Kandimalla, Wagner Baetas-Da-Cruz, Yogendra Kumar Mishra, Giorgio Palù, Adam M. Brufsky, Murtaza M. Tambuwala, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Two adenovirus-based vaccines, ChAdOx1 nCoV-19 and Ad26.COV2.S, and two mRNA-based vaccines, BNT162b2 and mRNA.1273, have been approved by the European Medicines Agency (EMA), and are invaluable in preventing and reducing the incidence of coronavirus disease-2019 (COVID-19). Recent reports have pointed to thrombosis with associated thrombocytopenia as an adverse effect occurring at a low frequency in some individuals after vaccination. The causes of such events may be related to SARS-CoV-2 spike protein interactions with different C-type lectin receptors, heparan sulfate proteoglycans (HSPGs) and the CD147 receptor, or to different soluble splice variants of the spike protein, adenovirus vector interactions with the …

The Signal Peptide Of The Amyloid Precursor Protein Forms Amyloid-Like Aggregates And Enhances Aβ42 Aggregation, Kundlik Gadhave, Taniya Bhardwaj, Vladimir N. Uversky, Michele Vendruscolo, Rajanish Giri

Molecular Medicine Faculty Publications

Signal sequences are short peptides at the N terminus of proteins destined for the secretion pathway. Typically, after cleavage by peptidases, signal peptides are degraded by intra-membrane proteases. In some cases, however, signal peptides can be processed further and released into the endoplasmic reticulum, secretion pathways, or cytoplasm. The consequences of these processes remain unclear, in particular considering that dysregulated signal peptides could potentially aggregate and induce cytotoxicity. To investigate this problem, we study the signal peptide of the amyloid precursor protein (APP), which originates the Alzheimer’s β-amyloid (Aβ) peptide. Our results show that this signal peptide (residues 1–17 of …

Race & Policing In America Symposium Transcript

St. Thomas Law Review

The symposium was moderated by Professor andré douglas pond cummings of University of Arkansas at Little Rock William H. Bowen School of Law.

Public Health Policing And The Case Against Vaccine Mandates, Dr. Tryon Woods

St. Thomas Law Review

There can be no simple reading of a text, be it literary, philosophical or scientific, nor of the social text in the most general sense. Rather, the question must turn upon itself, no less than its putative object, as a matter of interpretation and, more important, as a matter of the forces at work in the interpretative activity under way. There is always the ascription of voice to what is otherwise silent, the attribution of a face or the placement of a mask. Le germe n’est rien, c’est le terrain qui est tout. The microbe is nothing, the soil is …

National Survey Of Student Engagement 2021 High-Impact Practices (Main Campus), National Survey Of Student Engagement

National Survey of Student Engagement (NSSE) Reports

High-Impact Practices report provides a summary of the information contained in survey of first year and senior students on undergraduate opportunities that are designated as high-impact. Students are surveyed on participation in service-learning, learning community, research with faculty, internship or field experience, study abroad, and culminating senior experience.

National Survey Of Student Engagement 2021 High-Impact Practices (Lake Campus), National Survey Of Student Engagement

National Survey of Student Engagement (NSSE) Reports

High-Impact Practices report provides a summary of the information contained in survey of first year and senior students on undergraduate opportunities that are designated as high-impact. Students are surveyed on participation in service-learning, learning community, research with faculty, internship or field experience, study abroad, and culminating senior experience.

National Survey Of Student Engagement 2021 Respondent Profile (Lake Campus), National Survey Of Student Engagement

National Survey of Student Engagement (NSSE) Reports

The Respondent Profile presents both student- and institution-reported demographic information, allowing you to examine similarities and differences between your students and those at your comparison group institutions. This report uses information from all randomly selected or census-administered students. The display below highlights important details in the report to keep in mind when interpreting your results.

Slowing Down The Clock: Cellular Senescence And Aging, Saad Bhatti

AUCTUS: The Journal of Undergraduate Research and Creative Scholarship

No abstract provided.

Structural Changes In Neurons In Multiple Sclerosis, Saad Bhatti

AUCTUS: The Journal of Undergraduate Research and Creative Scholarship

No abstract provided.

Discovery Of Genetic Pleiotropy For Obesity And Inflammation And Mediation In Identified Variants Through Obesity-Related Pathways, Yiqian Wenren

Public Health Theses

Genetic data suggest that obesity and inflammation shared a portion of their genetic architectures. Meanwhile, epidemiologic data suggest a causal link between obesity and inflammation. Therefore, we hypothesized that there are variants in the human genome that display pleiotropy for obesity and inflammation and that the effects of at least some of those variants could be mediated by obesity-related pathways. To test these hypotheses, we conducted univariate genome-wide association analyses of obesity-related traits (BMI and WHRadjBMI) and inflammation (CRP) in the UK Biobank (n= 291,396 Caucasian subjects), searched for overlapping signals, fine-mapped the regions to identify putative causal SNPs, and …

Full Speed Ahead: Tdec 2021 Annual Report, Tennessee. Department Of Environment And Conservation

TDEC Annual Reports

This annual report highlights the accomplishments of the Tennessee Department of Environment and Conservation over the fiscal year.

Exploring The Connection Between The Spontaneous Regression Seen In Neuroblastomas, Hypertumors, And Reactive Oxygen Species, Shahad Musa, Manitha Mulpuru

AUCTUS: The Journal of Undergraduate Research and Creative Scholarship

Peto’s Paradox is defined as the lack of correlation between larger animals and cancer risk. Under the assumption that all cells have equal risk of becoming cancerous, larger animals should have greater rates of cancer. However, the inverse is true. Determining the cause of this variation may allow a supplemental approach to cancer treatment. A combination of two reasons may account for this correlation including hypertumors and metabolism. Hypertumors, or cheater cells, are hypothesized to suppress cancer growth through spontaneous autophagic degradation and overexpression of the RAS g-protein. Both of these characteristics are exhibited in Neuroblastomas. An anticancer drug used …

Pause For A Cybersecurity Cause: Assessing The Influence Of A Waiting Period On User Habituation In Mitigation Of Phishing Attacks, Amy Antonucci

CCAC Theses and Dissertations

Social engineering costs organizations billions of dollars a year. Social engineering exploits the weakest link of information security systems, the people who are using them. Phishing is a form of social engineering in which the perpetrator depends on the victim’s instinctual thinking towards an email designed to create a fear or excitement response. It is well-documented in literature that users continue to click on phishing emails costing them and their employers significant monetary resources and data loss. Training does not appear to mitigate the effects of phishing much; other solutions are necessary to mitigate phishing.

Kahneman introduced the concepts of …

Investigating The User Experience With A 3d Virtual Anatomy Application, Winnyanne Kunkle

CCAC Theses and Dissertations

Decreasing hours dedicated to teaching anatomy courses and declining use of human cadavers have spurred the need for innovative solutions in teaching anatomy in medical schools. Advancements in virtual reality (VR), 3D visualizations, computer graphics, and medical graphic images have enabled the development of highly interactive 3D virtual applications. Over recent years, variations of interactive systems on computer-mediated environments have been used as supplementary resource for learners. However, despite the growing sophistication of these resources for learning anatomy, studies show that students predominantly prefer traditional methods of learning and hands-on cadaver-based learning over computer-mediated platforms.

There is limited research on …

A Study Of Factors That Influence Symbol Selection On Augmentative And Alternative Communication Devices For Individuals With Autism Spectrum Disorder, William Todd Dauterman

CCAC Theses and Dissertations

According to the American Academy of Pediatrics (AAP), 1 in 59 children are diagnosed with Autism Spectrum Disorder (ASD) each year. Given the complexity of ASD and how it is manifested in individuals, the execution of proper interventions is difficult. One major area of concern is how individuals with ASD who have limited communication skills are taught to communicate using Augmentative and Alternative Communication devices (AAC). AACs are portable electronic devices that facilitate communication by using audibles, signs, gestures, and picture symbols. Traditionally, Speech-Language Pathologists (SLPs) are the primary facilitators of AAC devices and help establish the language individuals with …

Examining A Functional Interaction Between Chromatin Remodeler Chd1 And Histone H1 In D. Melanogaster, Breanna Kim

Scripps Senior Theses

Chromodomain-helicase-DNA-binding-protein-1 (CHD1) is a highly conserved ATP- dependent remodeling protein. It is localized to active genes and directs nucleosome spacing, while its loss has been linked to various human diseases, such as human prostate cancer. In Drosophila, CHD1 is important for fertility and wing development, and overexpression of CHD1 leads to severe wing vein defect phenotypes. The Linker Histone H1, which is known for maintaining heterochromatin and is associated with inactive genes, had been previously identified as a possible functional partner of CHD1, though the exact nature of their interaction is unclear. I undertook a genetic approach to examining the …