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2021

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How Do Beliefs Come Into Play? An Examination Of The Influence Of Core Conceptions On Science Teachers’ Inquiry Lesson Plan Designs, Mehmet Fatih Dulger Dec 2021

How Do Beliefs Come Into Play? An Examination Of The Influence Of Core Conceptions On Science Teachers’ Inquiry Lesson Plan Designs, Mehmet Fatih Dulger

UNLV Theses, Dissertations, Professional Papers, and Capstones

Teaching science through inquiry-based methodologies has been advocated by several governmental and professional organizations (National Research Council [NRC], 2000; NGSS Lead States, 2013); however, their use is not widespread. Why is this? What science teachers do in their classrooms is shaped by their beliefs, especially their beliefs about the nature of science, about the goals and purposes of school science and the goals of teaching science, and about the teaching and learning science. By critically examining these core conceptions and their influence on teacher lesson planning, this study aims to shed light on the role conceptions play when teachers design …


Quaternary Ammonium Compounds As Precursors To Disinfection Byproducts, Padmanabhan Krishnaswamy Dec 2021

Quaternary Ammonium Compounds As Precursors To Disinfection Byproducts, Padmanabhan Krishnaswamy

UNLV Theses, Dissertations, Professional Papers, and Capstones

Disinfection of drinking water is crucial for providing a safe potable water supply. Some of the most common disinfectants employed are chlorine, chloramines and ozone. While these disinfectants successfully inactivate pathogenic microorganisms, they simultaneously react with inorganic or organic precursors to form toxic byproducts, most commonly referred to as disinfection byproducts (DBPs). While there is a wide variety of organic matter and disinfection byproducts known, in this study we have looked into the potential of certain quaternary ammonium compounds (QACs) to act as precursors to form DBPs, namely trihalomethanes (THMs), haloacetonitriles (HANs) and nitrosamines.

The ubiquitous nature of QACs in …


The Influences Of Medicaid On Mental Health Practitioners, Matthew Mohan Dec 2021

The Influences Of Medicaid On Mental Health Practitioners, Matthew Mohan

UNLV Theses, Dissertations, Professional Papers, and Capstones

Medicaid is the largest publicly funded health insurance program which influences the mental health practitioners’ treatment of low income individuals (Altman & Frist, 2015; Rowland et al., 2003). To understand how Medicaid influences mental health practitioners, this study utilizes institutional theory by using the five propositions from Lammers and Barbour (2006) to analyze how Medicaid’s communicative practices influence mental health practitioners who treat those who are in poverty. Semi-structured interviews were conducted with 10 mental healthcare practitioners who accepted Medicaid: two psychologists, five social workers, one psychiatrist, and two psychiatric nurse practitioners. The results demonstrate how mental health practitioners respond …


Feasibility And Efficacy Of Virtual Darkness In Reducing Intra-Individual Sleep Variability Among Young Adults With Insomnia, Samantha Nicole Sherwood Dec 2021

Feasibility And Efficacy Of Virtual Darkness In Reducing Intra-Individual Sleep Variability Among Young Adults With Insomnia, Samantha Nicole Sherwood

UNLV Theses, Dissertations, Professional Papers, and Capstones

BackgroundInsomnia impacts 30% of people and is associated with increased risk for medical and psychiatric illness. However, pharmacological treatments for sleep yield mixed results and often result in undesirable side effects indicating a need for novel insomnia interventions. Sleep patterns also demonstrate high intra-individual variability which may be associated with greater daytime impairment, and sleep-wake cycles are strongly affected by the timing of exposure to blue-green wavelength light. Virtual darkness, a novel intervention, blocks blue wavelength light from reaching the eye to simulate actual darkness on retinal cells sensitive to light. Therefore, the purpose of the current study is to …


Hybridity, Ecocriticism, And Feminist Perspectives In She-Ra And The Princesses Of Power, Sarah Warso Dec 2021

Hybridity, Ecocriticism, And Feminist Perspectives In She-Ra And The Princesses Of Power, Sarah Warso

UNLV Theses, Dissertations, Professional Papers, and Capstones

Children’s cartoons are growing increasingly nuanced in the twenty-first century. She-Ra and the Princesses of Power (2018) is an animated television series targeted towards young girls that includes themes of ecocriticism and feminism. The show does this by introducing cyborg, or hybrid, characters. My research explores how cyborg identities in children’s media and their feminist, ecocritical meanings in She-Ra and the Princesses of Power. The cyborg, as a feminist mythic hero, breaks down binaries and recodes communication between opposing forces. The She-Ra is filled with characters that inhabit multiple identities. The main character, Adora, identifies as both a former Evil …


Association Of Serum Magnesium With Blood Pressure In Patients With Hypertensive Crises: A Retrospective Cross-Sectional Study, Ifeanyichukwu O. Onor, Lashira M. Hill, Modupe M. Famodimu, Mallory R. Coleman, Carolkim H. Huynh, Robbie A. Beyl, Casey J. Payne, Emily K. Johnston, John I. Okogbaa, Christopher J. Gillard, Daniel F. Sarpong, Amne Borghol, Samuel C. Okpechi, Ifeyinwa Norbert, Shane E. Sanne, Shane G. Guillory Dec 2021

Association Of Serum Magnesium With Blood Pressure In Patients With Hypertensive Crises: A Retrospective Cross-Sectional Study, Ifeanyichukwu O. Onor, Lashira M. Hill, Modupe M. Famodimu, Mallory R. Coleman, Carolkim H. Huynh, Robbie A. Beyl, Casey J. Payne, Emily K. Johnston, John I. Okogbaa, Christopher J. Gillard, Daniel F. Sarpong, Amne Borghol, Samuel C. Okpechi, Ifeyinwa Norbert, Shane E. Sanne, Shane G. Guillory

School of Graduate Studies Faculty Publications

The role of magnesium in blood pressure has been studied among hypertensive patients; however, there is a dearth of studies exploring the role of magnesium in hypertensive crises. The primary objective of this study was to evaluate the relationship between serum magnesium and blood pressure in patients with hypertensive crises. This was a singlecenter, retrospective, chart review, cross-sectional study of patients with hypertensive crises. Patients were included if they were eighteen years of age or older, with an international classification disease ninth revision (ICD-9) code of 401.9 (hypertensive crises: emergency or urgency) and a documented magnesium level on their electronic …


Ampk Modulation Ameliorates Dominant Disease Phenotypes Of Ctrp5 Variant In Retinal Degeneration, Kiyoharu J. Miyagishima, Ruchi Sharma, Malika Nimmagadda, Katharina Clore-Gronenborn, Zoya Qureshy, Davide Ortolan, Devika Bose, Mitra Farnoodian, Congxiao Zhang, Andrew Fausey, Yuri V. Sergeev, Mones Abu-Asab, Bokkyoo Jun, Khanh V. Do, Marie Audrey Kautzman Guerin, Jorgelina Calandria, Aman George, Bin Guan, Qin Wan, Rachel C. Sharp Dec 2021

Ampk Modulation Ameliorates Dominant Disease Phenotypes Of Ctrp5 Variant In Retinal Degeneration, Kiyoharu J. Miyagishima, Ruchi Sharma, Malika Nimmagadda, Katharina Clore-Gronenborn, Zoya Qureshy, Davide Ortolan, Devika Bose, Mitra Farnoodian, Congxiao Zhang, Andrew Fausey, Yuri V. Sergeev, Mones Abu-Asab, Bokkyoo Jun, Khanh V. Do, Marie Audrey Kautzman Guerin, Jorgelina Calandria, Aman George, Bin Guan, Qin Wan, Rachel C. Sharp

School of Graduate Studies Faculty Publications

Late-onset retinal degeneration (L-ORD) is an autosomal dominant disorder caused by a missense substitution in CTRP5. Distinctive clinical features include sub-retinal pigment epithelium (RPE) deposits, choroidal neovascularization, and RPE atrophy. In induced pluripotent stem cells-derived RPE from L-ORD patients (L-ORD-iRPE), we show that the dominant pathogenic CTRP5 variant leads to reduced CTRP5 secretion. In silico modeling suggests lower binding of mutant CTRP5 to adiponectin receptor 1 (ADIPOR1). Downstream of ADIPOR1 sustained activation of AMPK renders it insensitive to changes in AMP/ATP ratio resulting in defective lipid metabolism, reduced Neuroprotectin D1(NPD1) secretion, lower mitochondrial respiration, and reduced ATP production. These metabolic …


A Discipline In Search Of A Voice: A Corpus Linguistic Study Of Evaluation Scholarly Literature, Aaron Wilson Kates Dec 2021

A Discipline In Search Of A Voice: A Corpus Linguistic Study Of Evaluation Scholarly Literature, Aaron Wilson Kates

Dissertations

Linguists use the concept of discourse community (DC) to describe the speech of groups of people associated by some extrinsic purpose or interest (Swales, 1990). One defining feature of a DC is a shared lexicon. Scriven (1994), in his discussion of evaluation as a discipline, addresses the need for evaluation to have a “core subject” which would then allow, among other things, the development of “concepts and language to deal with core problems,” while noting that there exists a definite lack of clarity of language among evaluators (p. 147). Christie and Rose (2003) suggest that the lack of clarification around …


Post-Fire Tree Mortality And Regeneration Patterns As Proxies Of Conifer Forest Resilience, Sebastian Upton Busby Dec 2021

Post-Fire Tree Mortality And Regeneration Patterns As Proxies Of Conifer Forest Resilience, Sebastian Upton Busby

Dissertations and Theses

Shifting wildfire patterns and climate conditions, magnified by anthropogenic climate change, are threatening the resilience of conifer forests in North America and more specifically, the western US. If native conifer species are functionally maladapted to novel fire patterns and post-fire climate conditions, large-scale shifts in conifer forest structure, composition, and extent may occur as warming intensifies. Forest resilience in the context of fire and climate can be understood and quantified by the survival of trees through fire events and success of trees to regenerate post-fire and maintain population levels. In this dissertation, I use field observations and remote sensing to …


Synthesis, Isolation And Structural Elucidation Of Cage-Shaped Aluminum And Gallium Phosphorous Aryloxide Complexes As Highly Reactive Lewis Acids And Carboxyboranes As Carbon Monoxide Releasing Molecules (Corms), Hussam Wannas Shinawa Alhamza Dec 2021

Synthesis, Isolation And Structural Elucidation Of Cage-Shaped Aluminum And Gallium Phosphorous Aryloxide Complexes As Highly Reactive Lewis Acids And Carboxyboranes As Carbon Monoxide Releasing Molecules (Corms), Hussam Wannas Shinawa Alhamza

Theses and Dissertations

Group 13 Lewis acids have gained a lot of interest in over the years due to their reactivity, potency, and applications in the field of catalysis. Generally, there is a direct relationship between the catalytic activity of the organometallic Lewis acid and its acidity. However, this gives rise to a bigger challenge which is related to the stability of the catalyst. Our preliminary results from working on the catalytic reduction of CO2 have shown catalytic deactivation after one or two cycles. Utilizing bulkier substituents such as monodentate phenolates have shown promising increased stability and reactivity. The structural optimization (i.e., open-shape …


3d Printed Bioglass Incorporated Collagen Matrices For Musculoskeletal Tissue Engineering, Nilabh Sunil Kajave Dec 2021

3d Printed Bioglass Incorporated Collagen Matrices For Musculoskeletal Tissue Engineering, Nilabh Sunil Kajave

Theses and Dissertations

Musculoskeletal injuries are a major cause of disability affecting millions of people around the world and resulting in a significant economic burden of over $14 billion. Surgical intervention using autografts and allografts is the current gold standard used in the clinic for the repair and regeneration of musculoskeletal injuries, but these treatment options are associated with major limitations such as donor-site morbidity, need for multiple surgeries, immune-related complications, and risk for disease transmission. Over the past three decades, the development and application of tissue engineering strategies for restoration and reconstruction of damaged or diseased musculoskeletal tissues have gained considerable momentum …


Development And Optimization Of A Denitrification System To Promote Biological Nutrient Removal In A Subtropical Estuary, Abigail Gering Dec 2021

Development And Optimization Of A Denitrification System To Promote Biological Nutrient Removal In A Subtropical Estuary, Abigail Gering

Theses and Dissertations

Eutrophication impacts coastal ecosystems globally and triggers phytoplankton and algal blooms, leading to an increase in oxygen demand in the water column and sediments due to various biogeochemical processes. Naturally, biological nitrification, denitrification and anammox processes help to remove nitrogen predominately by nitrifying and denitrifying bacteria in the sediments. Eutrophic systems have increased nutrient and organic matter loading and are prone to the accumulation of ‘muddy’, fine-grained, organic-rich sediments (locally termed ‘muck’) that may not be able to support high enough populations of these bacteria, and therefore, may not adequately support nitrification/denitrification processes that would otherwise remove nitrogen. To decrease …


A Machine Learning-Based Approach To Predict And Optimize The Performance Of Zero Energy Building (Zeb): A Case Study For Florida, Benjamin Kubwimana Dec 2021

A Machine Learning-Based Approach To Predict And Optimize The Performance Of Zero Energy Building (Zeb): A Case Study For Florida, Benjamin Kubwimana

Theses and Dissertations

Machine learning is currently one of the most searched fields aiming to solve real-life problems. Building simulation software tools help engineers estimate building energy behaviors before the actual construction, allowing implementation of more energy efficient choices in building design and construction. Current building energy simulation software tools are mostly physics-based and still lack the benefit obtained with machine learningbased modeling, which offers fast and less computationally expensive techniques to build energy models and efficiently perform design optimization. This thesis presents a machine learning-based approach for building energy modeling and optimizing design parameters to minimize building’s energy consumption. The study is …


The Relationship Of Hospital Ceo Gender And The Patient Experience: The Role Of The Mediating Effects Of Hospital Characteristics, Lanean M. Lang Dec 2021

The Relationship Of Hospital Ceo Gender And The Patient Experience: The Role Of The Mediating Effects Of Hospital Characteristics, Lanean M. Lang

Electronic Theses and Dissertations

In this quantitative study, I investigated CEO gender and the patient experience in acute care hospitals in Texas for 2019. As the patient-experience has been the metric for quality patient care and hospital reimbursements, hospital CEOs play an important role in promoting positive patient experience as they lead the organization in strategic goals. The study is relevant as a shortage of experienced and qualified healthcare leaders is expected as baby-boomers retire. The lack of women leaders remains a challenging issue. The purpose of the study was to assess the gender differences of the CEO on the impact of patient experience …


Ultra-Conformal Skin Electrodes With Synergistically Enhanced Conductivity For Long-Time And Low-Motion Artifact Epidermal Electrophysiology, Yan Zhao, Song Zhang, Tianhao Yu, Yan Zhang, Guo Ye, Han Cui, Chengzhi He, Wenchao Jiang, Yu Zhai, Chunming Lu, Xiaodan Gu, Nan Liu Dec 2021

Ultra-Conformal Skin Electrodes With Synergistically Enhanced Conductivity For Long-Time And Low-Motion Artifact Epidermal Electrophysiology, Yan Zhao, Song Zhang, Tianhao Yu, Yan Zhang, Guo Ye, Han Cui, Chengzhi He, Wenchao Jiang, Yu Zhai, Chunming Lu, Xiaodan Gu, Nan Liu

Faculty Publications

Accurate and imperceptible monitoring of electrophysiological signals is of primary importance for wearable healthcare. Stiff and bulky pregelled electrodes are now commonly used in clinical diagnosis, causing severe discomfort to users for long-time using as well as artifact signals in motion. Here, we report a ~100 nm ultra-thin dry epidermal electrode that is able to conformably adhere to skin and accurately measure electrophysiological signals. It showed low sheet resistance (~24 Ω/sq, 4142 S/cm), high transparency, and mechano-electrical stability. The enhanced optoelectronic performance was due to the synergistic effect between graphene and poly (3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS), which induced a high …


Metacognition, Social Cognition, And Mentalizing In Psychosis: Are These Distinct Constructs When It Comes To Subjective Experience Or Are We Just Splitting Hairs?, P. H. Lysaker, S. Cheli, G. Dimaggio, B. Buck, K. A. Bonfils, K. Huling, C. Wiesepape, J. T. Lysaker Dec 2021

Metacognition, Social Cognition, And Mentalizing In Psychosis: Are These Distinct Constructs When It Comes To Subjective Experience Or Are We Just Splitting Hairs?, P. H. Lysaker, S. Cheli, G. Dimaggio, B. Buck, K. A. Bonfils, K. Huling, C. Wiesepape, J. T. Lysaker

Faculty Publications

Research using the integrated model of metacognition has suggested that the construct of metacognition could quantify the spectrum of activities that, if impaired, might cause many of the subjective disturbances found in psychosis. Research on social cognition and mentalizing in psychosis, however, has also pointed to underlying deficits in how persons make sense of their experience of themselves and others. To explore the question of whether metacognitive research in psychosis offers unique insight in the midst of these other two emerging fields, we have offered a review of the constructs and research from each field. Following that summary, we discuss …


Label-Free Characterization Of Organic Nanocarriers Reveals Persistent Single Molecule Cores For Hydrocarbon Sequestration, Terry Mcafee, Thomas Ferron, Isvar A. Cordova, Phillip D. Pickett, Charles L. Mccormick, Cheng Wang, Brian A. Collins Dec 2021

Label-Free Characterization Of Organic Nanocarriers Reveals Persistent Single Molecule Cores For Hydrocarbon Sequestration, Terry Mcafee, Thomas Ferron, Isvar A. Cordova, Phillip D. Pickett, Charles L. Mccormick, Cheng Wang, Brian A. Collins

Faculty Publications

Self-assembled molecular nanostructures embody an enormous potential for new technologies, therapeutics, and understanding of molecular biofunctions. Their structure and function are dependent on local environments, necessitating in-situ/operando investigations for the biggest leaps in discovery and design. However, the most advanced of such investigations involve laborious labeling methods that can disrupt behavior or are not fast enough to capture stimuli-responsive phenomena. We utilize X-rays resonant with molecular bonds to demonstrate an in-situ nanoprobe that eliminates the need for labels and enables data collection times within seconds. Our analytical spectral model quantifies the structure, molecular composition, and dynamics of a copolymer micelle …


Nutrient Content And Stoichiometry Of Pelagic Sargassum Reflects Increasing Nitrogen Availability In The Atlantic Basin, B. E. Lapointe, R. A. Brewton, L. W. Herren, M. Wang, C. Hu, D. J. Mcgillicuddy, S. Lindell, F. J. Hernandez, P. L. Morton Dec 2021

Nutrient Content And Stoichiometry Of Pelagic Sargassum Reflects Increasing Nitrogen Availability In The Atlantic Basin, B. E. Lapointe, R. A. Brewton, L. W. Herren, M. Wang, C. Hu, D. J. Mcgillicuddy, S. Lindell, F. J. Hernandez, P. L. Morton

Faculty Publications

The pelagic brown macroalgae Sargassum spp. have grown for centuries in oligotrophic waters of the North Atlantic Ocean supported by natural nutrient sources, such as excretions from associated fishes and invertebrates, upwelling, and N2 fixation. Using a unique historical baseline, we show that since the 1980s the tissue %N of Sargassum spp. has increased by 35%, while %P has decreased by 44%, resulting in a 111% increase in the N:P ratio (13:1 to 28:1) and increased P limitation. The highest %N and δ15N values occurred in coastal waters influenced by N-rich terrestrial runoff, while lower C:N and …


Accurate Diagnosis Of Colorectal Cancer Based On Histopathology Images Using Artificial Intelligence, K. S. Wang, G. Yu, C. Xu, X. H. Meng, J. Zhou, C. Zheng, Z. Deng, L. Shang, R. Liu, S. Su, X. Zhou, Q. Li, J. Li, J. Wang, K. Ma, J. Qi, Z. Hu, P. Tang, J. Deng, X. Qiu, B. Y. Li, W. D. Shen, R. P. Quan, J. T. Yang, L. Y. Huang, Y. Xiao, Z. C. Yang, Z. Li, S. C. Wang, H. Ren, C. Liang, W. Guo, Y. Li, H. Xiao, Y. Gu, J.P. Yun, D. Huang, Z. Song, X. Fan, L. Chen, X. Yan, Z. Li, Z.C. Huang, J. Huang, J. Luttrell, Chaoyang Zhang, W. Zhou, K. Zhang, C. Yi, C. Wu, H. Shen, Y.P. Wang, H.M. Xiao, H.W. Deng Dec 2021

Accurate Diagnosis Of Colorectal Cancer Based On Histopathology Images Using Artificial Intelligence, K. S. Wang, G. Yu, C. Xu, X. H. Meng, J. Zhou, C. Zheng, Z. Deng, L. Shang, R. Liu, S. Su, X. Zhou, Q. Li, J. Li, J. Wang, K. Ma, J. Qi, Z. Hu, P. Tang, J. Deng, X. Qiu, B. Y. Li, W. D. Shen, R. P. Quan, J. T. Yang, L. Y. Huang, Y. Xiao, Z. C. Yang, Z. Li, S. C. Wang, H. Ren, C. Liang, W. Guo, Y. Li, H. Xiao, Y. Gu, J.P. Yun, D. Huang, Z. Song, X. Fan, L. Chen, X. Yan, Z. Li, Z.C. Huang, J. Huang, J. Luttrell, Chaoyang Zhang, W. Zhou, K. Zhang, C. Yi, C. Wu, H. Shen, Y.P. Wang, H.M. Xiao, H.W. Deng

Faculty Publications

Background: Accurate and robust pathological image analysis for colorectal cancer (CRC) diagnosis is time-consuming and knowledge-intensive, but is essential for CRC patients’ treatment. The current heavy workload of pathologists in clinics/hospitals may easily lead to unconscious misdiagnosis of CRC based on daily image analyses.

Methods: Based on a state-of-the-art transfer-learned deep convolutional neural network in artificial intelligence (AI), we proposed a novel patch aggregation strategy for clinic CRC diagnosis using weakly labeled pathological whole-slide image (WSI) patches. This approach was trained and validated using an unprecedented and enormously large number of 170,099 patches, > 14,680 WSIs, from > 9631 subjects …


Osmr Signaling Induces Tamp-Specific Bbb Dysfunction Following Autoimmune-Mediated Neutrophil Recruitment, Travis Scott Wertz Dec 2021

Osmr Signaling Induces Tamp-Specific Bbb Dysfunction Following Autoimmune-Mediated Neutrophil Recruitment, Travis Scott Wertz

Boise State University Theses and Dissertations

Integrity of the brain microvessels that form the blood-brain barrier (BBB) is maintained through fine-tuned regulation of endothelial tight junction proteins, chiefly represented by claudin 5 and the tight junction-associated MARVEL protein (TAMP) occludin. Under proinflammatory conditions in autoimmune-mediated multiple sclerosis (MS), autoreactive effector T cells are activated in white matter regions of the brain and spinal cord and release cytokines to recruit circulating neutrophils that, in turn, release neurotoxic substances. Lack of tight junctions in peripheral blood vessels allows neutrophils to exit blood vessels unhindered, but BBB tight junctions must first be downregulated before neutrophils can transmigrate into the …


Hidden Markov Models Identify Major Movement Modes In Accelerometer And Magnetometer Data From Four Albatross Species, Melinda G. Conners, Théo Michelot, Eleanor I. Heywood, Rachael A. Orben, Richard A. Phillips, Alexei L. Vyssotski, Scott A. Shaffer, Lesley H. Thorne Dec 2021

Hidden Markov Models Identify Major Movement Modes In Accelerometer And Magnetometer Data From Four Albatross Species, Melinda G. Conners, Théo Michelot, Eleanor I. Heywood, Rachael A. Orben, Richard A. Phillips, Alexei L. Vyssotski, Scott A. Shaffer, Lesley H. Thorne

Faculty Research, Scholarly, and Creative Activity

Background: Inertial measurement units (IMUs) with high-resolution sensors such as accelerometers are now used extensively to study fine-scale behavior in a wide range of marine and terrestrial animals. Robust and practical methods are required for the computationally-demanding analysis of the resulting large datasets, particularly for automating classification routines that construct behavioral time series and time-activity budgets. Magnetometers are used increasingly to study behavior, but it is not clear how these sensors contribute to the accuracy of behavioral classification methods. Development of effective classification methodology is key to understanding energetic and life-history implications of foraging and other behaviors. Methods: We deployed …


Higher Habitual Flavonoid Intakes Are Associated With A Lower Risk Of Peripheral Artery Disease Hospitalizations, Nicola P. Bondonno, Kevin Murray, Aedin Cassidy, Catherine P. Bondonno, Joshua Lewis, Kevin D. Croft, Cecilie Kyro, Gunnar Gislason, Christian Torp-Pedersen, Augustin Scalbert, Anne Tjonneland, Jonathan M. Hodgson, Frederik Dalgaard Dec 2021

Higher Habitual Flavonoid Intakes Are Associated With A Lower Risk Of Peripheral Artery Disease Hospitalizations, Nicola P. Bondonno, Kevin Murray, Aedin Cassidy, Catherine P. Bondonno, Joshua Lewis, Kevin D. Croft, Cecilie Kyro, Gunnar Gislason, Christian Torp-Pedersen, Augustin Scalbert, Anne Tjonneland, Jonathan M. Hodgson, Frederik Dalgaard

Research outputs 2014 to 2021

Background

The role of nutrition in the primary prevention of peripheral artery disease (PAD), the third leading cause of atherosclerotic cardiovascular disease, is undetermined. Flavonoids may attenuate atherosclerosis and therefore persons who consume flavonoid-rich foods may have a lower risk of developing PAD.

Objectives

We aimed to examine the association between flavonoid intake and PAD hospitalizations and investigate if the association differs according to established risk factors for PAD.

Methods

Baseline data from 55,647 participants of the Danish Diet, Cancer, and Health Study without PAD, recruited from 1993 to 1997, were cross-linked with Danish nationwide registries. Flavonoid intake was calculated …


Analysis Of Circulating Tumour Cells In Early-Stage Uveal Melanoma: Evaluation Of Tumour Marker Expression To Increase Capture, Aaron B. Beasley, Timothy W. Isaacs, Tersia Vermeulen, James Freeman, Jean-Louis De Sousa, Riyaz Bhikoo, Doireann Hennessy, Anna Reid, Fred K. Chen, Jacqueline Bentel, Daniel Mckay, R. Max Conway, Michelle R. Pereira, Bob Mirzai, Leslie Calapre, Wendy N. Erber, Melanie R. Ziman, Elin S. Gray Dec 2021

Analysis Of Circulating Tumour Cells In Early-Stage Uveal Melanoma: Evaluation Of Tumour Marker Expression To Increase Capture, Aaron B. Beasley, Timothy W. Isaacs, Tersia Vermeulen, James Freeman, Jean-Louis De Sousa, Riyaz Bhikoo, Doireann Hennessy, Anna Reid, Fred K. Chen, Jacqueline Bentel, Daniel Mckay, R. Max Conway, Michelle R. Pereira, Bob Mirzai, Leslie Calapre, Wendy N. Erber, Melanie R. Ziman, Elin S. Gray

Research outputs 2014 to 2021

Background:

The stratification of uveal melanoma (UM) patients into prognostic groups is critical for patient management and for directing patients towards clinical trials. Current classification is based on clinicopathological and molecular features of the tumour. Analysis of circulating tumour cells (CTCs) has been proposed as a tool to avoid invasive biopsy of the primary tumour. However, the clinical utility of such liquid biopsy depends on the detection rate of CTCs.

Methods:

The expression of melanoma, melanocyte, and stem cell markers was tested in a primary tissue microarray (TMA) and UM cell lines. Markers found to be highly expressed in primary …


Corporations Without Representation: The Constitutionality Of Gender Diversity Mandates, Talley Ransil Dec 2021

Corporations Without Representation: The Constitutionality Of Gender Diversity Mandates, Talley Ransil

Utah Law Review

Biases and structural barriers contribute to the glacial pace at which women are represented on corporate boards. Even though companies with at least one female board of director outperform companies with no female directors, women only held 20% of board of director positions in 2019. Companies nationwide would not reach gender equality in the boardroom for decades without legally enforceable gender diversity requirements. In response, California Senator Jackson proposed SB 826—requiring California-based publicly held corporations to include at least one woman on their board of directors. However, conservative legal organizations filed lawsuits claiming California’s gender diversity mandate violates the California …


Effect Of Hydrogen Peroxide On Algae And Microcystin In Control And Lake Waters, Tatiana Castillo Hernandez Dec 2021

Effect Of Hydrogen Peroxide On Algae And Microcystin In Control And Lake Waters, Tatiana Castillo Hernandez

Biological and Agricultural Engineering Undergraduate Honors Theses

Cyanobacteria are photo-autotrophic organisms with a worldwide distribution, which can result in Harmful Algal Blooms (HABs) producing toxins. One of the most common strains of cyanobacteria is Microcystis, which produces the most abundant cyanotoxin, microcystin. In this study, we analyzed the effect of H2O2 on algae and microcystin using both lake and reagent grade water. The first objective was to determine the effect of H2O2 on algae and cyanobacteria in lake water that was nutrient enriched. The second objective was to detect the effect of H2O2 at oxidizing microcystin in …


Using Dynamic In Vivo Kinematics For Subject-Specific Calibration Of Knee Ligament Parameters, Stephen Nelson Dec 2021

Using Dynamic In Vivo Kinematics For Subject-Specific Calibration Of Knee Ligament Parameters, Stephen Nelson

Boise State University Theses and Dissertations

In vivo clinical studies are the optimal way to investigate the biomechanical outcomes of new prosthetic devices. This particular style of testing can be difficult and, in certain cases, unethical to perform. The testing of unproven devices, surgical techniques, and materials put patients at risk from unanticipated outcomes in how these devices respond to the in vivo environment and patient-specific loading conditions. Biomechanical computational models were developed to provide validation to new devices prior to clinical testing. Computational models for use in optimizing knee prosthetics frequently include ligament representations, but these representations have inherent uncertainty due to wide intersubject variation …


Liposomes: Production And Applications For Controlled Drug Delivery, Gamid Abatchev Dec 2021

Liposomes: Production And Applications For Controlled Drug Delivery, Gamid Abatchev

Boise State University Theses and Dissertations

This dissertation recognizes the enormous potential presented by the ever-evolving development of liposomes as drug carriers and seeks to offer further investigation into their useful production and utilization. The first chapter presents the basic principles governing their formation by self-assembly in water solutions, briefly describes the most common production methods, and points out essential past advances that led to their use as drug carriers. Chapter two exemplifies production of liposomes by the traditional methods of extrusion and sonication, detailing passive and active loading, as well as physical characterization by Dynamic Light Scattering, microscopy imaging, and fluorescence spectroscopy. In the next …


Training Wheels For Web Search: Multi-Perspective Learning To Rank To Support Children's Information Seeking In The Classroom, Garrett Allen Dec 2021

Training Wheels For Web Search: Multi-Perspective Learning To Rank To Support Children's Information Seeking In The Classroom, Garrett Allen

Boise State University Theses and Dissertations

Bicycle design has not changed for a long time, as they are well-crafted for those that possess the skills to ride, i.e., adults. Those learning to ride, however, often need additional support in the form of training wheels. Searching for information on the Web is much like riding a bicycle, where modern search engines (the bicycle) are optimized for general use and adult users, but lack the functionality to support non-traditional audiences and environments. In this thesis, we introduce a set of training wheels in the form of a learning to rank model as augmentation for standard search engines to …


From Microbes To Management: Spatial And Temporal Variations In Available Vegetation Affect The Gut Microbiota In A Population Of Free-Ranging Generalist Herbivores, Olivia K. Rodríguez Dec 2021

From Microbes To Management: Spatial And Temporal Variations In Available Vegetation Affect The Gut Microbiota In A Population Of Free-Ranging Generalist Herbivores, Olivia K. Rodríguez

Boise State University Theses and Dissertations

The effects of extrinsic environmental factors that shape ecological systems are not only seen at the macroscopic level, but additionally influence and govern the host-associated microbial communities of their mammalian hosts. These microbial communities are susceptible to the fluctuation of abiotic and biotic factors which affect their host organisms. The surge in the research of microbiota–communities of archaea, bacteria, fungi, and viruses residing in various environmental systems–has shown that these communities can profoundly influence animal health. As such, monitoring microbiota has allowed for a new approach to study animal health and physiology. This is of particular benefit in the conservation …


Social Media Influencers (Smis) In Context: A Literature Review, Charles Alves De Castro, Isobel O'Reilly Dr, Aiden Carthy Dec 2021

Social Media Influencers (Smis) In Context: A Literature Review, Charles Alves De Castro, Isobel O'Reilly Dr, Aiden Carthy

Articles

This review focused on three main areas, "Social Media Influencers (SMIs) in Context, The Impact of SMIs on Adolescents, and Consumer Behaviour in a Digital Era – Generation Z in Perspective". This article aims to further the overall understanding of SMIs and outlines the impact of SMIs on adolescents‘ lives. Thus, the main objective of this literature review is to raise awareness within the marketing field about the influence of social media influencers on adolescents and how brands promote their products and content through social media influencers. The review comprised a regular search using electronic journal databases and secondary data …