Digital Commons Network^™

Gabab Receptor Agonist R-Baclofen Reverses Altered Auditory Reactivity And Filtering In The Cntnap2 Knock-Out Rat, Dorit Möhrle, Wenxuan Wang, Shawn N Whitehead, Susanne Schmid

Anatomy and Cell Biology Publications

Altered sensory information processing, and auditory processing, in particular, is a common impairment in individuals with autism spectrum disorder (ASD). One prominent hypothesis for the etiology of ASD is an imbalance between neuronal excitation and inhibition. The selective GABA_B receptor agonist R-Baclofen has been shown previously to improve social deficits and repetitive behaviors in several mouse models for neurodevelopmental disorders including ASD, and its formulation Arbaclofen has been shown to ameliorate social avoidance symptoms in some individuals with ASD. The present study investigated whether R-Baclofen can remediate ASD-related altered sensory processing reliant on excitation/inhibition imbalance in the auditory brainstem. …

Pannexin 1 Binds Β-Catenin To Modulate Melanoma Cell Growth And Metabolism, Samar Sayedyahossein, Kenneth Huang, Zhigang Li, Christopher Zhang, Alexandra M. Kozlov, Danielle Johnston, Daniel Nouri-Nejad, Lina Dagnino, Dean H. Betts, David B. Sacks, Silvia Penuela

Paediatrics Publications

Melanoma is the most aggressive skin malignancy with increasing incidence worldwide. Pannexin1 (PANX1), a member of the pannexin family of channel-forming glycoproteins, regulates cellular processes in melanoma cells including proliferation, migration, and invasion/metastasis. However, the mechanisms responsible for coordinating and regulating PANX1 function remain unclear. Here, we demonstrated a direct interaction between the C-terminal region of PANX1 and the N-terminal portion of β-catenin, a key transcription factor in the Wnt pathway. At the protein level, β-catenin was significantly decreased when PANX1 was either knocked down or inhibited by two PANX1 blockers, Probenecid and Spironolactone. Immunofluorescence imaging showed a disrupted pattern …

Efficient Epileptic Seizure Detection Using Cnn-Aided Factor Graphs, Bahareh Salafian, Eyal Fishel Ben, Nir Shlezinger, Sandrine De Ribaupierre, Nariman Farsad

Paediatrics Publications

We propose a computationally efficient algorithm for seizure detection. Instead of using a purely data-driven approach, we develop a hybrid model-based/data-driven method, combining convolutional neural networks with factor graph inference. On the CHB-MIT dataset, we demonstrate that the proposed method can generalize well in a 6 fold leave-4-patient-out evaluation. Moreover, it is shown that our algorithm can achieve as much as 5% absolute improvement in performance compared to previous data-driven methods. This is achieved while the computational complexity of the proposed technique is a fraction of the complexity of prior work, making it suitable for real-time seizure detection.

Phosphorylation Of The Rb C-Terminus Regulates Condensin Ii Release From Chromatin, Seung J. Kim, James I. Macdonald, Frederick A. Dick

Paediatrics Publications

The retinoblastoma tumor suppressor protein (RB) plays an important role in biological processes such as cell cycle control, DNA damage repair, epigenetic regulation, and genome stability. The canonical model of RB regulation is that cyclin-CDKs phosphorylate and render RB inactive in late G1/S, promoting entry into S phase. Recently, monophosphorylated RB species were described to have distinct cell-cycle-independent functions, suggesting that a phosphorylation code dictates diversity of RB function. However, a biologically relevant, functional role of RB phosphorylation at non-CDK sites has remained elusive. Here, we investigated S838/T841 dual phosphorylation, its upstream stimulus, and downstream functional output. We found that …

Optimization And Biological Validation Of An In Vitro Assay Using The Transfected Dm28c/Placz Trypanosoma Cruzi Strain, Julian Ernesto Nicolas Gulin, Daniela Marisa Rocco, Victoria Alonso, Pamela Cribb, Jaime Altcheh, Facundo Garcia-Bournissen

Paediatrics Publications

There is an urgent need to develop safer and more effective drugs for Chagas disease, as the current treatment relies on benznidazole (BZ) and nifurtimox (NFX). Using the Trypanosoma cruzi Dm28c strain genetically engineered to express the Escherichia coli β-galactosidase gene, lacZ, we have adapted and validated an easy, quick and reliable in vitro assay suitable for high-throughput screening for candidate compounds with anti-T. cruzi activity. In vitro studies were conducted to determine trypomastigotes sensitivity to BZ and NFX from Dm28c/pLacZ strain by comparing the conventional labour-intensive microscopy counting method with the colourimetric assay. Drug concentrations producing the lysis of …

Crescent: Cancer Single Cell Expression Toolkit, Suluxan Mohanraj, J. Javier Díaz-Mejía, Martin D. Pham, Hillary Elrick, Mia Husić, Shaikh Rashid, Ping Luo, Prabnur Bal, Kevin Lu, Samarth Patel, Alaina Mahalanabis, Alaine Naidas, Erik Christensen, Danielle Croucher, Laura M. Richards, Parisa Shooshtari, Michael Brudno, Arun K. Ramani, Trevor J. Pugh

Paediatrics Publications

CReSCENT: CanceR Single Cell ExpressioN Toolkit (https://crescent.cloud), is an intuitive and scalable web portal incorporating a containerized pipeline execution engine for standardized analysis of singlecell RNA sequencing (scRNA-seq) data. While scRNA-seq data for tumour specimens are readily generated, subsequent analysis requires highperformance computing infrastructure and user expertise to build analysis pipelines and tailor interpretation for cancer biology. CReSCENT uses public data sets and preconfigured pipelines that are accessible to computational biology non-experts and are user-editable to allow optimization, comparison, and reanalysis for specific experiments. Users can also upload their own scRNA-seq data for analysis and results can be kept private …

Spatiotemporal And Functional Characterisation Of Transient Receptor Potential Vanilloid 4 (Trpv4) In The Murine Intervertebral Disc, M. K.M. Kim, R. Ramachandran, Cheryle A. Séguin

Paediatrics Publications

The molecular regulators of mechano-transduction in intervertebral disc (IVD) cells are not well understood. The aim of the present study was to characterise the expression and function of the mechano-sensitive ion channel TRPV4 in the IVD. A novel transgenic reporter mouse, in which the endogenous Trpv4 locus drove the expression of LacZ, was used to localise Trpv4 expression at specific stages of spine development [embryonic day (E) 8.5, 12.5, 17.5, postnatal day 1] and time points following skeletal maturity (2.5, 6, 9 and 12 months). The TRPV4-specific agonist GSK1016790A and antagonist GSK2193874 were used to assess the functional response of …

Epigenetic Memories And The Evolution Of Infectious Diseases, Geoff Wild

Biology Publications

Genes with identical DNA sequence may show differential expression because of epigenetic marks. Where epigenetic marks respond to past conditions, they represent a form of “memory”. Despite their medical relevance, the impact of memories on the evolution of infectious diseases has rarely been considered. Here we explore the evolution of virulence in pathogens that carry memories of the sex of their previous host. We show that this form of memory provides information about the sex of present and future hosts when the sexes differ in their pathogen’s transmission pattern. Memories of past hosts enable the evolution of greater virulence in …

Kinetic Analysis Of Dominant Intraprostatic Lesion Of Prostate Cancer Using Quantitative Dynamic [18F]Dcfpyl-Pet: Comparison To [18F]Fluorocholine-Pet, Dae Myoung Yang, Fiona Li, Glenn Bauman, Joseph Chin, Stephen Pautler, Madeleine Moussa, Irina Rachinsky, John Valliant, Ting Yim Lee

Medical Biophysics Publications

Purpose: Identification of the dominant intraprostatic lesion(s) (DILs) can facilitate diagnosis and treatment by targeting biologically significant intra-prostatic foci. A PSMA ligand, [ F]DCFPyL (2-(3-{1-carboxy-5-[(6-[ F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid), is better than choline-based [ F]FCH (fluorocholine) in detecting and localizing DIL because of higher tumour contrast, particularly when imaging is delayed to 1 h post-injection. The goal of this study was to investigate whether the different imaging performance of [ F]FCH and [ F]DCFPyL can be explained by their kinetic behaviour in prostate cancer (PCa) and to evaluate whether DIL can be accurately detected and localized using a short duration dynamic positron …

Disease-Related Cortical Thinning In Presymptomatic Granulin Mutation Carriers, Sergi Borrego-Écija, Roser Sala-Llonch, John Van Swieten, Barbara Borroni, Fermín Moreno, Mario Masellis, Carmela Tartaglia, Caroline Graff, Daniela Galimberti, Robert Laforce, James B. Rowe, Elizabeth Finger, Rik Vandenberghe, Fabrizio Tagliavini, Alexandre De Mendonça, Isabel Santana, Matthis Synofzik, Simon Ducharme, Johannes Levin, Adrian Danek, Alex Gerhard, Markus Otto, Chris Butler, Giovanni Frisoni, Sandro Sorbi, Carolin Heller, Martina Bocchetta, David M. Cash, Rhian S. Convery, Katrina M. Moore, Jonathan D. Rohrer, Raquel Sanchez-Valle

Medical Biophysics Publications

Mutations in the granulin gene (GRN) cause familial frontotemporal dementia. Understanding the structural brain changes in presymptomatic GRN carriers would enforce the use of neuroimaging biomarkers for early diagnosis and monitoring. We studied 100 presymptomatic GRN mutation carriers and 94 noncarriers from the Genetic Frontotemporal dementia initiative (GENFI), with MRI structural images. We analyzed 3T MRI structural images using the FreeSurfer pipeline to calculate the whole brain cortical thickness (CTh) for each subject. We also perform a vertex-wise general linear model to assess differences between groups in the relationship between CTh and diverse covariables as gender, age, the estimated years …

Fsu Law Focus - 06/01/2021, Fsu College Of Law Office Of Communications

FSU Law Focus Newsletter

From the Dean: Juris Master Program expanding; Prof. Abbott Presents to the WHO and WTO; Alum Profile: Robin L. Suarez (’89); Student Profile: 2021 Grad Chase Allen

A Study Of Bone Histology Procedures And Applications, Breanna Smith

Student Research Poster Presentations 2021

Bone histology paired with ontogeny can allow for discovery of the way in which an individual grows. “Bone” umbrellas so many types and patterns which are all linked to both environmental and genetic influences. Vascular patterns allow for the differentiation of growth rates and growth periods. Veracious usage of terminology and proper specimen selection can lead to these explanations.

Facilitating Peace Leadership, Stan Amaladas

International Journal of Peace Studies

Informed by the disciplines of Leadership Studies and Peace and Conflict Studies, the author offers an understanding of peace leadership as being an interconnected affair of the head (consciousness-raising), heart (feeling the need for transformative change), hands (to be moved to purposive action) and the holy (offering all the sacred gift of treating persons as persons). Building on an earlier publication in this Journal, this article reconstructs conditions for peace at intrapersonal, interpersonal, and cultural levels. It also offers a deutero learning framework and model for coordinating the efforts for the sake of peace through an understanding of leadership as …

Fear Vs Facts: Unpacking The Government Of Canada's Facebook Strategy Against Covid-19 Vaccine Hesitancy, Carol Saldanha

Communication Studies Major Research Papers

This study looks at how the Government of Canada used its Facebook page ‘Healthy Canadians,’ during the COVID-19 pandemic to address vaccine hesitancy. It focuses on the communication strategies used to reduce fear and build trust. By using critical discourse analysis, the research examines the language and other communicative tactics employed to engage a skeptical public. The paper reviews the causes of vaccine hesitancy, the role of social media in spreading both fear and facts, and the challenges of balancing persuasive messaging while respecting individual rights. The findings show how the government used communication tools on Facebook to counter misinformation …

Inventions Of Scientists, Engineers And Specialists From Different Countries In The Area Of Nanotechnologies. Part I, Leonid A. Ivanov, Li Da Xu, Elena Bokova, Aleksandr D. Ishkov, Svetlana Muminova

Information Technology & Decision Sciences Faculty Publications

The article provides an abstract review of patents. The results of creative activity of scientists, engineers and specialists, including inventions in the field of nanotechnology and nanomaterials, being implemented, allow achieving a significant effect in construction, housing and community services, and related sectors of the economy. For example, the invention (A method to produce graphene-containing suspensions by means of graphite exfoliation and a device to perform it) refers to chemical and construction industries and can be used in modification of plastic lubricant, epoxy resins and concretes. The technical task of the invention is to increase efficiency of graphite exfoliation, to …

Inventions Of Scientists, Engineers And Specialists From Different Countries In The Area Of Nanotechnologies. Part Ii, Leonid A. Ivanov, Li Da Xu, Zhanna V. Pisarenko, Qiang Wang, Petr S. Prokopiev

Information Technology & Decision Sciences Faculty Publications

The article provides an abstract review of patents. The results of creative activity of scientists, engineers and specialists, including inventions in the field of nanotechnology and nanomaterials, being implemented, allow achieving a significant effect in construction, housing and community services, and related sectors of the economy. For example, the invention «Method for liquidphase synthesis of nanostructured ceramic material in the CeO2–Sm2O3 system to create a solid oxide fuel cell» can contribute to the active development of alternative, hydrogen energy. Fuel cells have a wide range of applications – from batteries in portable electronic devices to large-scale power generation and autonomous …

Metabolic Reprogramming And Cell Adhesion In Acute Leukemia Adaptation To The Cns Niche, Nitesh D. Sharma, Esra'a Keewan, Ksenia Matlawska-Wasowska

Pediatrics Research and Scholarship

Involvement of the Central Nervous System (CNS) in acute leukemia confers poor prognosis and lower overall survival. Existing CNS-directed therapies are associated with a significant risk of short- or long-term toxicities. Leukemic cells can metabolically adapt and survive in the microenvironment of the CNS. The supporting role of the CNS microenvironment in leukemia progression and dissemination has not received sufficient attention. Understanding the mechanism by which leukemic cells survive in the nutrient-poor and oxygen-deprived CNS microenvironment will lead to the development of more specific and less toxic therapies. Here, we review the current literature regarding the roles of metabolic reprogramming …

Open Neuroscience Initiative, Austin Lim

College of Science and Health Full Text Publications

The Open Neuroscience Initiative is a free-to-use textbook

This project began as a means to overcoming the financial burden that face undergraduate neuroscience students when buying textbooks. By compiling and writing a completely free-to-access textbook that covers the foundations of a typical college introduction to neuroscience course, students would have one less obstacle to overcome in their educational career, allowing them to focus their valuable time and attention on learning rather than finances. To make this project a reality, I began with a humble tweet in May 2019 that managed to gain a tiny bit of traction among the neuroscience …

2021 Uni Football Media Guide, University Of Northern Iowa

Athletics Media Guides

Contents:

Quick Facts/Contents --- 1
Personnel Breakdown --- 2
Numerical Roster --- 3
Alphabetical Roster --- 5
Roster by Position Group --- 7
The Program --- 8
Panther Sports Properties/Radio/TV --- 10
The Future of Panther Football --- 11
Media Policies/Staff --- 12
Campus Map --- 13
Head Coach Mark Farley --- 15
Assistant Coaches/Staff --- 18
Returner Bios --- 22
Newcomer Bios --- 49
2021 Spring Opponent Capsules --- 57
Series History vs. All Opponents --- 59
Season Quick Hits --- 69
Season Statistics --- 73
Box Scores/Recaps --- 78
Individual Game Records --- 81
Individual Season Records --- …

Underwater Nuclear Inspection Remotely Operated Drone, Chris Mcafee, Jr Knapp, Shane Derby, Pat Eddy

Mechanical Engineering Capstone Design Projects

The focus here is the visual inspection of submerged fuel elements within a nuclear reactor core. The underwater remotely controlled stable platform is a solution to improve the process at the Rhode Island Nuclear Science Center and Los Alamos National Laboratory with regard to fuel element inspection. The design offers a radiation resistant, stable, and buoyancy neutral ROV. The impact the design will have on the sponsors using the ROV is both improved image quality due to the stability and the ability to capture angles previously unattainable. Furthermore, a safer method of inspection as the drone can be controlled from …

A Biblioguidance Approach To Understanding And Developing Adolescents’ Social-Emotional Competence In The Health Education Classroom: A Formative Research Study, Jennifer R. Banas, Julia Valley, Amina Chaudhri

Health Sciences and Physical Education Faculty Publications

Purpose

Though the benefits of social-emotional competence (SEC) are well-recognized, measuring it and designing appropriately matched interventions remains elusive and methodologically challenging. This paper shares formative research designed to uncover the SEC of one secondary school health teacher's students and to help her make evidence-based curricular and instructional decisions.

Design/methodology/approach

Inspired by bibliguidance (or bibliotherapeutic) approaches to well-being, the researchers and teacher developed a fiction literature curriculum intended to foster SEC and health literacy skills. A mixed-method approach was used to gather and analyze data from 133 students and a teacher. A survey and journal entries embedded into the curriculum, …

High Serine-Arginine Protein Kinase 1 Expression With Pten Loss Defines Aggressive Phenotype Of Prostate Cancer Associated With Lethal Outcome And Decreased Overall Survival, Hatem Abou Ouf, Hisham Assem, Sunita Ghosh, R. Jeffrey Karnes, Konstantin Stoletov, Nallasivam Palanisamy, John D. Lewis, Tarek A. Bismar

Urology Articles

Background: Serine-arginine protein kinase 1 (SRPK1) has been implicated in prostate cancer (PCa) progression. However, its prognostic value and association with ERG and PTEN expression, two of the most common genetic alterations, have not been explored fully.

Objective: We assessed the prognostic value of SRPK1 in association with ERG and PTEN in a cohort of patients managed nonsurgically by androgen deprivation therapy (ADT) for advanced disease.

Design, setting, and participants: The study cohort consisted of men diagnosed with PCa by transurethral resection of the prostate (TURP; n = 480). The patients were divided into three main groups: incidental (patients with …

Magnetism In Curved Geometries, R. Streubel, Evgeny Y. Tsymbal, P. Fischer

Evgeny Tsymbal Publications

No abstract provided.

Timber Talk, Vol. 59, No. 3, September 2021

Timber Talk: Nebraska Forest Industry Newsletter

Timber Talk, Vol. 59, No. 3, September 2021

Timber Talk, Vol. 59, No. 4, December 2021

Timber Talk: Nebraska Forest Industry Newsletter

Timber Talk, Vol. 59, No. 4, December 2021

Timber Talk, Vol. 59, No. 1, March 2021

Timber Talk: Nebraska Forest Industry Newsletter

Timber Talk, Vol. 59, No. 1, March 2021

Rapid Survey Of Anuran Species In Baguio-Benguet Area And Isolation Of Their Fungal Symbionts, Arthien Lovell P. Pelingen, Camille Andrea Flores, Axel John Briz, Roland Hipol, Celia Austria

Biology Faculty Publications

Baguio City is one of the fastest-growing centers of urbanization in the Philippines. As part of the Cordillera Mountain Range, it is a biodiversity hotspot that is largely unexplored. This study is a preliminary investigation using visual encounter surveys of anuran species in various localities of the Baguio-Benguet area (BBA). These include Loakan Airport (LA), Camp John Hay (CJH), and Soroptimist Compound (SC) at the Military Cut Off, all in Baguio; Nangalisan, Tuba (NT), Benguet; and Master’s Garden (MG) at Puguis, La Trinidad, Benguet. We documented three Luzon-endemic species of frogs – namely, Kaloula rigida (Family Microhylidae), Sanguirana luzonensis (Family …

Aquatic Coleoptera Of Northern Negros, Philippines, Marc Ryan Sabordo, Carl Michael Buyco, Gwendalyn Henares, Jessica Pacalioga, Hendrik Freitag

Biology Faculty Publications

The water beetle fauna of northern Negros Island has not been comprehensively studied. In this study, aquatic Coleoptera of northern Negros have been compiled from various collections. Specimens were sampled through manual sampling and light trap. Twenty-six (26) species were recorded including 21 which are Philippine endemics. Nine genera and three known species are recorded for the first time from Negros.. Notes on distribution, ecology and identification are provided. Possible new species, future potential discoveries as well as current significance in terms of conservation are discussed.

Cochlear Implant Education Amongst Speech Language Pathologists, Alexandra Wojtowicz

Brehm Scholars Research

Speech-Language Pathologists (SLPs) are the professionals that oversee cochlear implant (CI) habilitation. However, SLPs encompass a wide range of training and experience levels or have an emerging specialized field of expertise. Consequently, not all SLPs may be adequately equipped to treat a client with a CI on their caseload. Previous research has indicated that SLPs lack the knowledge and confidence to treat clients with CIs on their caseload (Watson & Martin, 1999; Babeu, 2016; Compton, Tucker, and Flynn, 2009); yet, there has been limited research in regards to understanding SLPs’ education and training levels on CIs. The purpose of this …

Fashion, Models, And Intellectual Property, Andres Sawicki

Articles

In this Article, I revisit the impact of Professor Kal Raustiala and Professor Christopher Sprigman 's landmark article, The Piracy Paradox. Their work identified an empirical anomaly that was difficult to explain in light of the standard justification for intellectual property rights: although IP law does not grant meaningful exclusivity in novel fashion designs, the fashion industry invests significant resources developing those novel designs. To account for this anomaly, The Piracy Paradox shifted the focus from the supply side of innovation to the demand side. The standard justification emphasized that innovators face threats of copying that they cannot easily …