Digital Commons Network^™

Identification Of Novel Tubb1 Variants In Patients With Macrothrombocytopenia, Zi̇hni̇ Onur Çalişkaner, Abdullah Abdul Waheed, Merve Tuzlakoğlu Öztürk, Yeşi̇m Oymak, Uygar Hali̇s Tazebay, Mehmet Nejat Akar, Ayten Kandi̇lci̇, Di̇dem Özkan

Turkish Journal of Medical Sciences

Background/aim: Macrothrombocytopenia is an autosomal-dominant disorder characterized by increased platelet size and a decreased number of circulating platelets. The membrane skeleton and the link between actin filaments of the skeleton and microtubules, which consist of alpha and beta tubulin [including the tubulin beta-1 chain (TUBB1)] heterodimers, are important for normal platelet morphology, and defects in these systems are associated with macrothrombocytopenia. Materials and methods: In this study, we sequenced the exons of the TUBB1 gene using DNA isolated from the peripheral blood samples of healthy controls (n = 47) and patients with macrothrombocytopenia (n = 37) from Turkey. The TUBB1 …

Evaluation Of Serum Anti-Müllerian Hormone Levels In Women With Hashimotothyroiditis In The Reproductive Age, İlknur Öztürk Ünsal, Sema Hepşen, Pinar Akhanli, Murat Çalapkulu, Muhammed Erkam Sencar, Ali̇ Yalçindağ, Erman Çakal

Turkish Journal of Medical Sciences

Background/aim: Autoimmune thyroid disease in women is associated with subfertility and early pregnancy loss, and patients with primary ovarian insufficiency have a high prevalence of thyroid autoimmune disorders. The aim of this study was to investigate the association between Hashimoto thyroiditis (HT) and ovarian reserve. Materials and methods: Levels of serum thyroid stimulating hormones, thyroid autoantibodies, and anti-Müllerian hormone (AMH) were measured in women with HT and a healthy control group between 2018 and 2019. Results: Evaluation was made of 108 premenopausal women with HT, and a control group of 172 healthy females with normal antithyroid antibody levels and thyroid …

Clustering Hypergraphs Via The Mapequation, Matthew Swan, Justin Zhan

Computer Science and Computer Engineering Faculty Publications and Presentations

A hypergraph is a generalization of a graph in that the restriction of pairwise affinity scores is lifted in favor of affinity scores that can be evaluated between an arbitrary number of inputs. Hypergraphs clustering is the process of finding groups in which members of a given hypergraph exhibit a high similarity and dissimilarity with members outside their group. In this paper, we generalize the well-known MapEquation, an optimization equation used in the clustering of nonhypergraphs, for hypergraphs. We develop an agglomerative algorithm, Hypergraph Random Walks (HRW), to find an approximate solution to the generalized MapEquation. Our algorithm requires neither …

Shark Parent August 2021, Nova Southeastern University

NSU Parent Newsletter

No abstract provided.

Shark Parent September 2021, Nova Southeastern University

NSU Parent Newsletter

No abstract provided.

Validation Of The Short Version Of The Dimensional Inventory For Child Development Assessment, Euclides José De Mendonc¸A Filho, Mônia Aparecida Da Silva, Natalie A. Koziol, Denise Ruschel Bandeira

Nebraska Center for Research on Children, Youth, Families, and Schools: Faculty Publications

Objectives: There is a critical need to monitor the development of children around the world, and in Brazil, this need is substantial since there is a paucity of assessment tools. This study aimed to describe the design and provide evidence of reliability and validity for the short version of the Dimensional Inventory for Child Development Assessment (IDADI-short). Methods: A sample of 1,865 biological mothers of children aged 4---72 months (M = 34.8, SD = 20.20) completed the IDADI to assess Cognitive, socio-emotional, Expressive, and Receptive Language and Communication, Fine and Gross Motor, and Adaptive Behavior development. The psychometric …

Validation Of The Short Version Of The Dimensional Inventory For Child Development Assessment, Euclides José De Mendonça Filho, Mônia Aparecida Da Silva, Natalie A. Koziol, Denise Ruschel Bandeira

Nebraska Center for Research on Children, Youth, Families, and Schools: Faculty Publications

Objectives: There is a critical need to monitor the development of children around the world, and in Brazil, this need is substantial since there is a paucity of assessment tools. This study aimed to describe the design and provide evidence of reliability and validity for the short version of the Dimensional Inventory for Child Development Assessment (IDADI-short).

Methods: A sample of 1,865 biological mothers of children aged 4---72 months (M = 34.8, SD = 20.20) completed the IDADI to assess Cognitive, socio-emotional, Expressive, and Receptive Language and Communication, Fine and Gross Motor, and Adaptive Behavior development. The psychometric properties of …

Graduate Medical Education Annual Report 2020-2021, Children's Mercy Hospital

GME Annual Reports

Annual report of the Children's Mercy Hospital Graduate Medical Education department, including pediatric residency, internal medicine/pediatrics residency, fellowship programs, medical students, continuing medical education, and library services.

2021-2022 Graduate Catalog, Wku Graduate School

Graduate School

Graduate School catalog regarding admissions, curriculum and policies.

Barren County Kentucky's Mill Creek Chism Family & Their Virginian Ancestors Part 1, Kentucky Library Research Collections

Genealogical Records

No abstract provided.

The Effects Of Acute Exercise On Short-And Long-Term Memory: Considerations For The Timing Of Exercise And Phases Of Memory, Paul D. Loprinzi, Sierra Day, Rebecca Hendry, Sara Hoffman, Alexis Love, Sarah Marable, Elizabeth Mckee, Sydney Stec, Hanna Watson, Brittney Gilliland

Faculty and Student Publications

The specific questions addressed from this research include: (1) Does high-intensity acute exercise improve memory?, (2) If so, do the mechanisms occur via encoding, consolidation, or retrieval? and (3) If acute exercise occurs in multiple phases of memory (e.g., before encoding and during consolidation), does this have an additive effect on memory? Three experimental, within-subject, counterbalanced studies were conducted among young adults. High-intensity exercise involved a 20-minutes bout of exercise at 75% of heart rate reserve. Memory was evaluated from a word-list task, including multiple evaluations out to 24-hours post-encoding. The timing of the exercise and memory assessments were carefully …

Rab35 Centered Membrane Trafficking Pathway Directs Apical Constriction During Drosophila Gastrulation, Hui Miao

Electronic Theses and Dissertations

Force generation in epithelial tissues is often pulsatile, with actomyosin networks generating high-tension contractile forces at the cell cortex before cyclically disassembling. This pulsed nature of cytoskeletal forces implies that there must be cellular processes to extract unidirectional changes that drive processive transformations in cell shape. During Drosophila melanogastergastrulation, the invagination of the prospective mesoderm is driven by the pulsed constriction of apical surfaces. Here, we address the mechanisms by which the irreversibility of pulsed events is achieved while also permitting uniform epithelial behaviors to emerge. We use MSD-based analyses to identify contractile steps and find that when a …

Fxs-Causing Point Mutations In Fmrp Disrupt Neuronal Granule Formation And Function, Emily L. Starke

Electronic Theses and Dissertations

Fragile X Syndrome (FXS) is a neurodevelopmental disorder caused by the disruption of Fragile X Mental Retardation Protein (FMRP) function in neurons, affecting nearly 1 in 7,500 individuals. Although FXS typically occurs from a complete loss of FMRP expression due to a CGG trinucleotide expansion within the 5’UTR of the FMR1 gene, single nucleotide polymorphisms (SNPs) within the KH domains of FMRP have been shown to severely disrupt FMRP function. FMRP is an RNA-binding translation repressor that interacts with ~4% of the neuronal transcriptome. Many target mRNAs encode for proteins important for regulating synaptic processes and modulate synaptic plasticity. It …

An Investigation Of When The Antitrust Agencies Are Likely To Challenge A Pay-For-Delay Settlement Under Actavis, Thomas Y. Lu

Journal of Business & Technology Law

No abstract provided.

Uab Magazine - Spring/Summer 2021, University Of Alabama At Birmingham

UAB Magazine

No abstract provided.

Assessing Pace-Of-Life: Comparing Metabolism And Behavior In Tarantulas, Haley Vanscoyoc

Master's Theses and Doctoral Dissertations

Pace-of-Life Syndrome (PoLS) links physiology, behavior, and life history to understand how an organism lives and is under-researched in many invertebrate groups. In this study I used five tarantula species to assess if they follow the predictions of PoLS. I compared individual species as well as Old- and New-World lineages and solitary and sub-social species. I predicted that Old- World and sub-social species would have higher resting metabolic rates (RMRs) and activity levels compared to New-World and solitary species. RMRs were measured using an open-flow respirometry system, and a classic open-arena test was used to assess activity level. Spearman’s correlation …

Promoting Inclusive Metrics Of Success And Impact To Dismantle A Discriminatory Reward System In Science, Sarah W. Davies, Hollie M. Putnam, Tracy Ainsworth, Julia K. Baum, Colleen B. Bove, Sarah C. Crosby, Isabelle M. Côté, Anne Duplouy, Robinson W. Fulweiler, Alyssa J. Griffin, Torrance C. Hanley, Tessa Hill, Adriana Humanes, Sangeeta Mangubhai, Anna Metaxes, Laura M. Parker, Hanny E. Rivera, Nyss J. Sibiger, Nicola S. Smith, Ana K. Spaulding, Nikki Traylor-Knowles, Brooke L. Weigel, Rachel M. Wright, Amanda E. Bates

Biological Sciences Faculty Publications

Success and impact metrics in science are based on a system that perpetuates sexist and racist “rewards” by prioritizing citations and impact factors. These metrics are flawed and biased against already marginalized groups and fail to accurately capture the breadth of individuals’ meaningful scientific impacts. We advocate shifting this outdated value system to advance science through principles of justice, equity, diversity, and inclusion. We outline pathways for a paradigm shift in scientific values based on multidimensional mentorship and promoting mentee well-being. These actions will require collective efforts supported by academic leaders and administrators to drive essential systemic change.

Digital Image Processing To Detect Subtle Motion In Stony Coral, Shuaifeng Li, Liza M. Roger, Lokender Kumar, Nastassja A. Lewinski, Judith Klein-Seetharaman, Alex Gagnon, Hollie M. Putnam, Jinkyu Yang

Biological Sciences Faculty Publications

Coral reef ecosystems support significant biological activities and harbor huge diversity, but they are facing a severe crisis driven by anthropogenic activities and climate change. An important behavioral trait of the coral holobiont is coral motion, which may play an essential role in feeding, competition, reproduction, and thus survival and fitness. Therefore, characterizing coral behavior through motion analysis will aid our understanding of basic biological and physical coral functions. However, tissue motion in the stony scleractinian corals that contribute most to coral reef construction are subtle and may be imperceptible to both the human eye and commonly used imaging techniques. …

Improved Transformation Efficiency Of Group A Streptococcus By Inactivation Of A Type I Restriction Modification System, Meredith B. Flynn, Kathryn M. Ramsey, Hunter J. Tolliver, Simon L. Dove, Michael R. Wessels

Cell and Molecular Biology Faculty Publications

Streptococcus pyogenes or group A Streptococcus (GAS) is a leading cause of bacterial pharyngitis, skin and soft tissue infections, life-threatening invasive infections, and the post-infectious autoimmune syndromes of acute rheumatic fever and post-streptococcal glomerulonephritis. Genetic manipulation of this important pathogen is complicated by resistance of the organism to genetic transformation. Very low transformation efficiency is attributed to recognition and degradation of introduced foreign DNA by a type I restriction-modification system encoded by the hsdRSM locus. DNA sequence analysis of this locus in ten GAS strains that had been previously transformed with an unrelated plasmid revealed that six of the ten …

A Survey Of Spontaneous Antibiotic-Resistant Mutants Of The Halophilic, Thermophilic Bacterium Rhodothermus Marinus, Sophia Silvia, Samantha A. Donahue, Erin E. Killeavy, Gerwald Jogi, Steven T. Gregory

Cell and Molecular Biology Faculty Publications

Rhodothermus marinus is a halophilic extreme thermophile, with potential as a model organism for studies of the structural basis of antibiotic resistance. In order to facilitate genetic studies of this organism, we have surveyed the antibiotic sensitivity spectrum of R. marinus and identified spontaneous antibiotic-resistant mutants. R. marinus is naturally insensitive to aminoglycosides, aminocylitols and tuberactinomycins that target the 30S ribosomal subunit, but is sensitive to all 50S ribosomal subunit-targeting antibiotics examined, including macrolides, lincosamides, streptogramin B, chloramphenicol, and thiostrepton. It is also sensitive to kirromycin and fusidic acid, which target protein synthesis factors. It is sensitive to rifampicin (RNA …

Changes In Selection Pressure Can Facilitate Hybridization During Biological Invasion In A Cuban Lizard, Dan G. Bock, Simon Baeckens, Jessica N. Pita-Aquino, Zachary A. Chejanovski, Sozos N. Michaeolides, Pavitra Muralidhar, Sungdae Park, Douglas B. Menke, Anthony J. Geneva, Jonathan B. Losos, Jason J. Kolbe

Biological Sciences Faculty Publications

Hybridization is among the evolutionary mechanisms most frequently hypothesized to drive the success of invasive species, in part because hybrids are common in invasive populations. One explanation for this pattern is that biological invasions coincide with a change in selection pressures that limit hybridization in the native range. To investigate this possibility, we studied the introduction of the brown anole (Anolis sagrei) in the southeastern United States. We find that native populations are highly genetically structured. In contrast, all invasive populations show evidence of hybridization among native-range lineages. Temporal sampling in the invasive range spanning 15 y showed …

Fine-Scale Morphological, Genomic, Reproductive, And Symbiont Differences Delimit The Caribbean Octocorals Plexaura Homomalla And P. Kükenthali, Jessie A. Pelosi, Moisés A. Bernal, Trevor J. Krabbenhoft, Samantha Galbo, Carlos Prada, Mary Alice Coffroth, Howard Lasker

Biological Sciences Faculty Publications

Octocorals are conspicuous members of coral reefs and deep-sea ecosystems. Yet, species boundaries and taxonomic relationships within this group remain poorly understood, hindering our understanding of this essential component of the marine fauna. We used a multifaceted approach to revisit the systematics of the Caribbean octocorals Plexaura homomalla and Plexaura kükenthali, two taxa that have a long history of taxonomic revisions. We integrated morphological and reproductive analyses with high-throughput sequencing technology to clarify the relationship between these common gorgonians. Although size and shape of the sclerites are significantly different, there is overlap in the distributions making identification based on …

Training Graduate Students In Multiple Genres Of Public And Academic Science Writing: An Assessment Using An Adaptable, Interdisciplinary Rubric, Erin R. Harrington, Ingrid E. Lofgren, Caroline Gottschalk Druschke, Nancy E. Karraker, Nedra Reynolds, Scott R. Mcwilliams

Natural Resources Science Faculty Publications

There is an urgent need for scientists to improve their communication skills with the public, especially for those involved in applying science to solve conservation or human health problems. However, little research has assessed the effectiveness of science communication training for applied scientists. We responded to this gap by developing a new, interdisciplinary training model, “SciWrite,” based on three central tenets from scholarship in writing and rhetoric: 1) habitual writing, 2) multiple genres for multiple audiences, and 3) frequent review and created an interdisciplinary rubric based on these tenets to evaluate a variety of writing products across genres. We used …

In Search Of Equality For Women: From Suffrage To Civil Rights, Nan D. Hunter

Duquesne Law Review

This article analyzes women’s rights advocacy and its impact on evolutions in the meaning of gender equality during the period from the achievement of suffrage in 1920 until the 1964 Civil Rights Act. The primary lesson is that one cannot separate the conceptualization of equality or the jurisprudential philosophy underlying it from the dynamics and characteristics of the social movements that actively give it life. Social movements identify the institutions and practices that will be challenged, which in turn determines which doctrinal issues will provide the raw material for jurisgenerative change. Without understanding a movement’s strategy and opportunities for action, …

The Future Of Our Fingerprints: The Importance Of Instituting Biometric Data Protections In Pennsylvania, Julia M. Siracuse

Duquesne Law Review

No abstract provided.

Small Scale Plasma Gasification Of Municipal Solid Waste, Keith Male

Civil and Environmental Engineering Master's Project Reports

The goal of this project was to develop a prototype plasma gasification system to treat municipal solid waste (MSW) with minimal regulated emissions in a footprint small enough to be transported for a wide range of applicability. This project started with a review of current MSW treatment methods and of the emissions produced from thermal breakdown of MSW. A review of air quality regulations and emission control technologies was then used to select the emission control systems to be used for a small-scale plasma gasification system.

This plasma gasification system began with a plasma torch and cooling system being designed, …

Suffolk University Law School Alumni Magazine, Winter 2021 Issue, Suffolk University Law School

Suffolk Law School Alumni Magazine

No abstract provided.

An Ecological Assessment Of Critically Endangered Chinese Pangolin Manis Pentadactyla (Mammalia: Pholidota: Manidae) In The Midhills Region Of Nepal, Sandeep Shrestha, Ashish Bashyal, Rojeena Rijal, Janam Shrestha, Palistha Shrestha, Nischal Shrestha, Thomas J. Mcgreevy Jr., Bill Buffum, Sanjay Nath Khanal

Natural Resources Science Faculty Publications

The Chinese Pangolin (Manis pentadactyla) is a “Critically Endangered” insectivorous mammal. There is a lack of information on the ecology, distribution and behavior of this species in Nepal, even though community forests in the Midhills Region of Nepal are considered to be prime habitats for the species. We conducted an ecological assessment of the habitat use of this species in nine community forests covering an area of 170.69 ha in Balthali village in Kavrepalanchok district, Nepal. We divided each forest into 50 × 50 m grids and searched for Chinese Pangolin burrows along 50 m transects in each …

Riparian Zone Nitrogen Management Through The Development Of The Riparian Ecosystem Management Model (Remm) In A Formerly Glaciated Watershed Of The Us Northeast, Marzia Tamanna, Soni M. Pradhanang, Arthur J. Gold, Kelly Addy, Philippe G. Vidon

Natural Resources Science Faculty Publications

The Riparian Ecosystem Management Model (REMM) was developed, calibrated and validated for both hydrologic and water quality data for eight riparian buffers located in a formerly glaciated watershed (upper Pawcatuck River Watershed, Rhode Island) of the US Northeast. The Annualized AGricultural Non-Point Source model (AnnAGNPS) was used to predict the runoff and sediment loading to the riparian buffer. Overall, results showed REMM simulated water table depths (WTDs) and groundwater NO₃-N concentrations at the stream edge (Zone 1) in good agreement with measured values. The model evaluation statistics showed that, hydrologically REMM performed better for site 1, site 4, …

Dietary Vitamin E Reaches The Mitochondria In The Flight Muscle Of Zebra Finches But Only If They Exercise, Clara Cooper-Mullin, Wales A. Carter, Ronald S. Amato, David Podlesak, Scott R. Mcwilliams

Natural Resources Science Faculty Publications

Whether dietary antioxidants are effective for alleviating oxidative costs associated with energy-demanding life events first requires they are successfully absorbed in the digestive tract and transported to sites associated with reactive species production (e.g. the mitochondria). Flying birds are under high energy and oxidative demands, and although birds commonly ingest dietary antioxidants in the wild, the bioavailability of these consumed antioxidants is poorly understood. We show for the first time that an ingested lipophilic antioxidant, α-tocopherol, reached the mitochondria in the flight muscles of a songbird but only if they regularly exercise (60 min of perch-to-perch flights two times in …