Digital Commons Network^™

Effects Of Thinning On Dynamics And Drought Resistance Of Aspen-White Spruce Mixtures: Results From Two Study Sites In Saskatchewan, Philip G. Comeau

Aspen Bibliography

Drought stress associated with warm temperatures is causing increased mortality and reduced growth of trees in drier portions of the boreal forests of western Canada with both warming and drought expected to increase over the coming decades. While thinning is often shown to reduce drought stress, there is little information on its effects in stands comprised of mixtures of trembling aspen and white spruce that are common in the forests of this region. This study examined effects of pre-commercial thinning on aspen and spruce growth, response to drought stress, and stand dynamics for two study sites located in Saskatchewan, Canada. …

Volume Cxxxix, Number 9, January 15, 2021, Lawrence University

The Lawrentian

No abstract provided.

Myeloid-Derived Suppressor Cells In Gastrointestinal Cancers: A Systemic Review., Maham Farshidpour, Monjur Ahmed, Shilpa Junna, Juanita L. Merchant

Division of Internal Medicine Faculty Papers & Presentations

Gastrointestinal (GI) cancers are one of the most common malignancies worldwide, with high rates of morbidity and mortality. Myeloid-derived suppressor cells (MDSCs) are major components of the tumor microenvironment (TME). MDSCs facilitate the transformation of premalignant cells and play roles in tumor growth and metastasis. Moreover, in patients with GI malignancies, MDSCs can lead to the suppression of T cells and natural killer cells. Accordingly, a better understanding of the role and mechanism of action of MDSCs in the TME will aid in the development of novel immune-targeted therapies.

The Effects Of Kindergarten And First Grade Schooling On Executive Function And Academic Skill Development: Evidence From A School Cutoff Design, Matthew H. Kim, Sammy F. Ahmed, Frederick J. Morrison

Psychology Faculty Publications

Early executive function (EF) skills reliably predict school readiness and future academic success. While children’s skills undergo rapid development during the transition to formal schooling, it remains unclear the extent to which schooling exerts a unique influence on the accelerated development of EF and academic skills during the early years of schooling. In the present study, a quasi-experimental technique known as the school cutoff design was used to examine whether same-aged children who made vs. missed the age cutoff for school entry significantly differed on EF, reading, and math outcomes. Data from 166 pre-k, kindergarten, and first grade children (Range …

High-Density Lipoproteins And Serum Amyloid A (Saa), Nancy R. Webb

Pharmacology and Nutritional Sciences Faculty Publications

PURPOSE OF REVIEW: Serum amyloid A (SAA) is a highly sensitive acute phase reactant that has been linked to a number of chronic inflammatory diseases. During a systemic inflammatory response, liver-derived SAA is primarily found on high-density lipoprotein (HDL). The purpose of this review is to discuss recent literature addressing the pathophysiological functions of SAA and the significance of its association with HDL.

RECENT FINDINGS: Studies in gene-targeted mice establish that SAA contributes to atherosclerosis and some metastatic cancers. Accumulating evidence indicates that the lipidation state of SAA profoundly affects its bioactivities, with lipid-poor, but not HDL-associated, SAA capable of …

Using College Student Learning Experiences And Outcomes To Guide Teaching Modifications In A General Education Choreography Course: An Action Research Study, Kristy Kuhn Donnelly

Educational Studies Dissertations

The purpose of this action research study was to gain an understanding of the learning experiences and outcomes of 12 undergraduates enrolled in Creative Dance, a general education choreography course, in Fall 2019 and the teaching strategies and practices that guided their learning. Research questions that guided this study were: what does student work reveal about their learning and the teaching strategies that guide their learning? and what curricula and teaching changes will more effectively facilitate student learning processes and stronger outcomes? Qualitative data included standard instructional materials created for and utilized in the course and students’ choreographic and written …

Whole-Genome Screen Identifies Diverse Pathways That Negatively Regulate Ciliogenesis., Marion Failler, Ariadna Giro-Perafita, Mikito Owa, Shalini Srivastava, Chi Yun, David J Kahler, Derya Unutmaz, Francisco J Esteva, Irma Sánchez, Brian D Dynlacht

Faculty Research 2021

We performed a high-throughput whole-genome RNAi screen to identify novel inhibitors of ciliogenesis in normal and basal breast cancer cells. Our screen uncovered a previously undisclosed, extensive network of genes linking integrin signaling and cellular adhesion to the extracellular matrix (ECM) with inhibition of ciliation in both normal and cancer cells. Surprisingly, a cohort of genes encoding ECM proteins was also identified. We characterized several ciliation inhibitory genes and showed that their silencing was accompanied by altered cytoskeletal organization and induction of ciliation, which restricts cell growth and migration in normal and breast cancer cells. Conversely, supplying an integrin ligand, …

Transdisciplinary Ai Observatory—Retrospective Analyses And Future-Oriented Contradistinctions, Nadisha Marie Aliman, Leon Kester, Roman Yampolskiy

Faculty and Staff Scholarship

In the last years, artificial intelligence (AI) safety gained international recognition in the light of heterogeneous safety-critical and ethical issues that risk overshadowing the broad beneficial impacts of AI. In this context, the implementation of AI observatory endeavors represents one key research direction. This paper motivates the need for an inherently transdisciplinary AI observatory approach integrating diverse retrospective and counterfactual views. We delineate aims and limitations while providing hands-on-advice utilizing concrete practical examples. Distinguishing between unintentionally and intentionally triggered AI risks with diverse socio-psycho-technological impacts, we exemplify a retrospective descriptive analysis followed by a retrospective counterfactual risk analysis. Building on …

A Global Review On Short Peptides: Frontiers And Perspectives, Vasso Apostolopoulos, Joanna Bojarska, Tsun-Thai Chai, Sherif Elnagdy, Krzysztof Kaczmarek, John Matsoukas, Roger New, Keykavous Parang, Octavio Paredes Lopez, Hamideh Parhiz, Conrad O. Perera, Monica Pickholz, Milan Remko, Michele Saviano, Mariusz Skwarczynski, Yefeng Tang, Wojciech M. Wolf, Taku Yoshiya, Janusz Zabrocki, Piotr Zielenkiewicz, Maha Alkhazindar, Vanessa Barriga, Konstantinos Kelaidonis, Elham Mousavinezhad Sarasia, Istvan Toth

Pharmacy Faculty Articles and Research

Peptides are fragments of proteins that carry out biological functions. They act as signaling entities via all domains of life and interfere with protein-protein interactions, which are indispensable in bio-processes. Short peptides include fundamental molecular information for a prelude to the symphony of life. They have aroused considerable interest due to their unique features and great promise in innovative bio-therapies. This work focusing on the current state-of-the-art short peptide-based therapeutical developments is the first global review written by researchers from all continents, as a celebration of 100 years of peptide therapeutics since the commencement of insulin therapy in the 1920s. …

Genetic Transformation In Cryptococcus Species, Ping Wang

School of Medicine Faculty Publications

Genetic transformation plays an imperative role in our understanding of the biology in unicellular yeasts and filamentous fungi, such as Saccharomyces cerevisiae, Aspergillus nidulans, Cryphonectria parasitica, and Magnaporthe oryzae. It also helps to understand the virulence and drug resistance mechanisms of the pathogenic fungus Cryptococcus that causes cryptococcosis in health and immunocompromised individuals. Since the first attempt at DNA transformation in this fungus by Edman in 1992, various methods and techniques have been developed to introduce DNA into this organism and improve the efficiency of homology-mediated gene disruption. There have been many excellent summaries or reviews covering the subject. Here …

Metabolomics-Based Analysis Of Miniature Flask Contents Identifies Tobacco Mixture Use Among The Ancient Maya, Mario Zimmermann, Korey J. Brownstein, Luis Pantoja Díaz, Iliana Ancona Aragón, Scott R. Hutson, Barry Kidder, Shannon Tushingham, David R. Gang

Anthropology Faculty Publications

A particular type of miniature ceramic vessel locally known as “veneneras” is occasionally found during archaeological excavations in the Maya Area. To date, only one study of a collection of such containers successfully identified organic residues through coupled chromatography–mass spectrometry methods. That study identified traces of nicotine likely associated with tobacco. Here we present a more complete picture by analyzing a suite of possible complementary ingredients in tobacco mixtures across a collection of 14 miniature vessels. The collection includes four different vessel forms and allows for the comparison of specimens which had previously formed part of museum exhibitions with recently …

Fall/Winter 2020-21: Commitment To A Job Well Done, St. Norbert College

St. Norbert College Magazine 2019-2023

Wayne Patterson (History) is among those who have wrapped up long careers of service at St. Norbert.

Analysis Of Broadest Impact Implementation For A Developing Point Of Care Device Using Antibody Antigen Reactions, Sienna Dugan, Gabrielle J. Gonzales, Kelly Little

SMU Journal of Undergraduate Research

With the recent launch of the Global Development Lab in the Hunter and Stephanie Hunt Institute for Engineering and Humanity, fellows, faculty, and industry professionals have been working to create meaningful solutions to promote a resilient humanity, addressing the UN’s Sustainable Development Goals and challenges. The Institute has taken on Dr. Ali Beskok’s project, the development of a low cost, portable, Point-of-Care-Device for humanitarian and health applications. This paper provides a systematic review of current Point-of-Care-Devices using antibody antigen reactions. Additionally, it provides aspects of a market analysis and a literature review. Its overarching goal is to make recommendations regarding …

Ketamine’S Role In Spirituality: How One Synthetic Drug Catalyzes A Natural Experience, Samiah Woods

SMU Journal of Undergraduate Research

This article highlights the potential spiritual effects of a popular anesthetic, ketamine, and how these spiritual effects can be used to help promote the reconciliation of spiritual and physical health. Ketamine, like the prominent psychedelic, psilocybin, has reportedly caused feelings of spiritual revelation and “out of body experiences” that many physicians may not feel qualified to discuss with their patients. This reluctance to address ketamine-induced spiritual experiences may affect the health outcomes of the patient. The primary goal of this project is to bring academic validity to considerations of the spiritual health of patients. This paper (1) investigates the extent …

Developing An Archaeologically Literate Citizenry Through Public Archaeology: Assessing Archaeology Websites, Lisa Marie Catto

Dissertations and Theses

Assessment has been a growing focus of public archaeology in recent years, however, most assessment has focused on in-person activities with little on digital public archaeology. With the pervasive popularity of digital media, such as websites, among global public audiences and the popularity of websites as a communication tool for archaeologists, it is critical that archaeologists focus on evaluating websites to make this public-facing communications tool as effective as possible. My thesis addressed this gap in assessment by using Qualitative Content Analysis (QCA) to assess the messaging on the most popular archaeology websites, defined based on Google ranking. My specific …

Addressing The Practical Limitations Of Volatile Organic Compound Sensors Through An Oscillator-Based Sensing Array, Allison K. Murray, Joseph R. Meseke, Nikhil Bajaj, Jeffrey F. Rhoads

Mechanical Engineering Faculty Research and Publications

This work demonstrated the development of an array of oscillator-based sensors for the detection of volatile organic compounds (VOCs). A field-programmable gate array (FPGA) was leveraged to monitor the oscillation frequency of 16 sensing elements in parallel. It was shown that three functional chemistries can be deposited via inkjet printing to detect several analytes selectively. These unique response characteristics allowed for the creation of a linear regression model that relates the shifts in oscillation frequencies to the concentration of specific analytes. This approach utilized a single array with sufficient elements to incorporate intentional redundancies. Ultimately, this work demonstrated a low-cost …

Idealism, Pragmatism, And The Power Of Compromise In The Negotiation Of New Zealand's Zero Carbon Act, Ian Bailey, Oscar Fitch-Roy, Inderberg Th Jackson, David Benson

School of Geography, Earth and Environmental Sciences

Discursive choices made by policy entrepreneurs are an important factor in the development of climate change acts (CCAs). This article examines the extent to which such choices reflect the strategic need for CCA entrepreneurs to compromise pragmatically and modulate their policy preferences in order to secure the agreement needed for CCA adoption. Drawing upon theoretical insights from discursive institutionalism (DI) and policy entrepreneurship, this article analyses discursive choices during negotiations surrounding the New Zealand Zero Carbon Act (ZCA). The analysis shows that endogenous political-ideological constraints compelled entrepreneurial actors to modify first-choice preferences for emissions reduction legislation by reframing their coordinative …

Neural Coding And Organization Principles In The Drosophila Olfactory System, Haoyang Rong

McKelvey School of Engineering Graduate Student Theses & Dissertations

Sensory systems receive and process external stimuli to allow an organism to perceive and react to the environment. How is sensory information subsequently represented, transformed, and interpreted in the neural system? In this dissertation, I have investigated this fundamental question using the fruit fly (Drosophila melanogaster) olfactory system.Chemical cues are transduced into neural signals in the insect antenna by the olfactory receptor neurons (ORNs). The ORNs send their axons to the antennal lobe (AL), with each ORN type innervating a specific neuropil (glomerulus), where they synapse onto excitatory and inhibitory projection neurons (ePNs and iPNs). The ePNs project their axons …

Focused Ultrasound-Mediated Drug Delivery To The Brainstem, Dezhuang Ye

McKelvey School of Engineering Graduate Student Theses & Dissertations

Brainstem gliomas are tumors that occur in the brainstem, the brain region that connects the brain to the spinal cord and controls vital body functions. The critical anatomic location of the brainstem precludes surgical intervention and limits the use of invasive therapeutic techniques. Moreover, the frequently intact blood-brain barrier (BBB) of most brainstem gliomas prevents therapeutic agents from reaching the diseased site. The currently available techniques for brain drug delivery are either invasive (e.g., convection-enhanced delivery) or lack targeting to the diseased site (e.g., intranasal brain drug delivery). Novel techniques that can noninvasively overcome the BBB are critically needed for …

Instagram Use And Young Women's Body Image And Self-Objectification In Egypt, Sara Hussein

Theses and Dissertations

The present study investigates the effect of Instagram use on young Egyptian women’s body image and how it is related to self-objectification. The aim of this research is to understand how Instagram usage affects women’s body image and makes them dissatisfied with their bodies; besides, it also tests how the comments women receive on their Instagram accounts affect them positively or negatively, and how the more hours they spend on Instagram, the more pressure they face to acquire a better body shape. Additionally, it examines the direct relationship between feministic beliefs and body surveillance and self-objectification. Moreover, self-objectification and Cultivation …

Graphene Oxide Biopolymer Aerogels For The Removal Of Lead From Drinking Water Using A Novel Nano-Enhanced Ion Exchange Cascade, J. M. Bloor, R. D. Handy, S. A. Awan, D. F.L. Jenkins

School of Engineering, Computing and Mathematics

No abstract provided.

Sustainable Bioproduction By Rhodopseudomonas Palustris Tie-1 Through Metabolic Engineering, Wei Bai

McKelvey School of Engineering Graduate Student Theses & Dissertations

The heavy reliance of the petroleum industry for raw material and the rising atmospheric CO2 caused by this reliance have driven the research and development of sustainable alternatives. Microbial production of chemicals, such as fuel and plastic, has been viewed as a feasible method. The wide selection of substrates by microbes enables them to produce chemicals using naturally abundant material or industrial waste, such as CO2, making the production sustainable. Compared to the model organisms such as Escherichia coli, Saccharomyces cerevisiae, many non-model organisms have a broader selection for carbon, electron, and nitrogen sources, making them great candidates for sustainable …

Mapping Transcription Factor Networks And Elucidating Their Biological Determinants, Yiming Kang

McKelvey School of Engineering Graduate Student Theses & Dissertations

A central goal in systems biology is to accurately map the transcription factor (TF) network of a cell. Such a network map is a key component for many downstream applications, from developmental biology to transcriptome engineering, and from disease modeling to drug discovery. Building a reliable network map requires a wide range of data sources including TF binding locations and gene expression data after direct TF perturbations. However, we are facing two roadblocks. First, rich resources are available only for a few well-studied systems and cannot be easily replicated for new organisms or cell types. Second, when TF binding and …

Differentiating Human Embryonic Stem Cells In Micropatterns To Study Cell Fate Specification And Morphogenetic Events During Gastrulation, Kyaw Thu Minn

McKelvey School of Engineering Graduate Student Theses & Dissertations

During mammalian embryogenesis, the first major lineage segregation occurs when embryonic epiblast, and extraembryonic trophectoderm and hypoblast arise in the blastocyst. In the next fundamental and conserved phase of animal embryogenesis known as gastrulation, extraembryonic cells provide signals to epiblast to instruct embryonic patterning, and epiblast gives rise to germ layers ectoderm, mesoderm, and endoderm, that will establish all embryonic tissues. Proper specification and morphogenesis of germ layers during gastrulation is vital for correct embryonic development. Due to ethical and legal restrictions limiting human embryo studies, human gastrulation is poorly understood. Our knowledge of human gastrulation has largely been derived …

Uncovering The Roles And Evolved Sequence Grammar Of Hypervariable Intrinsically Disordered Proteins In Bacterial Cell Division, Megan Cohan

McKelvey School of Engineering Graduate Student Theses & Dissertations

Across all domains of life, a defining hallmark of the onset of cell division is the formation of a cytokinetic ring at the center of the cell. Cell division is a tightly controlled process that involves various regulatory factors that modulate the assembly of the cytokinetic ring. In rod-shaped bacteria, the ring is termed the Z-ring after the protein FtsZ, which is foundational to ring formation and is the bacterial homolog of tubulin. Like tubulin, FtsZ is an assembling GTPase, where GTP binding promotes the cooperative assembly into FtsZ polymers that laterally associate to form bundles. While the GTPase domain …

Discovery And Characterization Of Circular And Chimeric Rnas In Complex Diseases, Xiaoxin Liu

McKelvey School of Engineering Graduate Student Theses & Dissertations

Non-co-linear RNAs, including circular and chimeric RNAs, have been investigated in a broad range of cellular processes and various diseases. The current biogenesis models of circular and chimeric RNAs depend on RNA splicing mechanisms. We hypothesized that some of the non-co-linear RNAs are products of an alternative mechanism other than RNA splicing. To test this hypothesis, we developed a method, which is independent of genome annotations and splicing signals, to identify Circular and Chimeric RNAs of All Types (C2AT or CAT for simplicity) by analyzing the RNA species profiled by whole genome RNA sequencing. Statistical analysis and experimental validation revealed …

Constructing And Analyzing Neural Network Dynamics For Information Objectives And Working Memory, Elham Ghazizadeh Ahsaei

McKelvey School of Engineering Graduate Student Theses & Dissertations

Creation of quantitative models of neural functions and discovery of underlying principles of how neural circuits learn and compute are long-standing challenges in the field of neuroscience. In this work, we blend ideas from computational neuroscience, information and control theories with machine learning to shed light on how certain key functions are encoded through the dynamics of neural circuits. In this regard, we pursue the ‘top-down’ modeling approach of engineering neuroscience to relate brain functions to basic generative dynamical mechanisms. Our approach encapsulates two distinct paradigms in which ‘function’ is understood. In the first part of this research, we explore …

Nanoscale Enhancement Of Photosensitized Radionuclide Stimulated Therapy, Daniel Douglas Lane

McKelvey School of Engineering Graduate Student Theses & Dissertations

Photodynamic therapy (PDT) provides efficient tumor killing through the generation of reactive oxygen species (ROS) from the optical excitation of a photosensitizer (PS). Furthermore, this mechanism is highly immune stimulating, providing systemic tumor immunity with a reduction in metastasis. However, these materials had previously been limited by their dependence upon external light sources, allowing treatment of only laser-accessible malignancy. With the recent development of photosensitized radiation stimulated therapy (PRaST) this depth dependence is broken through co-localization of radionuclides and semiconducting photosensitizers. This dissertation focuses on the enhancement of titanium dioxide (TiO2) based PRaST agents through understanding of TiO2 material parameters …

Evaluating The Structural And Functional Consequences Of Traumatic Joint Injury And Their Relation To Nf-Κb In A Non-Invasive Model Of Post-Traumatic Osteoarthritis, Ian Matthew Berke

McKelvey School of Engineering Graduate Student Theses & Dissertations

Post-traumatic osteoarthritis (PTOA) is a painful and debilitating disease of the synovial joint, characterized by degenerative changes to various joint tissues following traumatic joint injury. While several risk factors have been identified in the symptomatic progression of PTOA following injury, inflammation and NF-κB mediated changes are believed to significantly contribute to symptomatic joint dysfunction and pain. However, the temporal presentation of these pro-inflammatory signals following clinically relevant injury and their relationship to the development of symptomatic disease have not been thoroughly investigated. Therefore, there exists a critical need to better understand how these early inflammatory events following injury may contribute …

Theory, Design And Implementation Of Energy-Efficient Biotelemetry Using Ultrasound Imaging, Sri Harsha Kondapalli

McKelvey School of Engineering Graduate Student Theses & Dissertations

This dissertation investigates the fundamental limits of energy dissipation in establishing a communication link with implantable medical devices using ultrasound imaging-based biotelemetry.

Ultrasound imaging technology has undergone a revolution during the last decade due to two primary innovations: advances in ultrasonic transducers that can operate over a broad range of frequencies and progresses in high-speed, high-resolution analog-to-digital converters and signal processors. Existing clinical and FDA approved bench-top ultrasound systems cangenerate real-time high-resolution images at frame rates as high as 10000 frames per second. On the other end of the spectrum, portable and hand-held ultrasound systems can generate high-speed real-time scans, …