Digital Commons Network^™

Topsentinol L Trisulfate, A Marine Natural Product That Targets Basal-Like And Claudin-Low Breast Cancers, Nader N. El-Chaar, Thomas E. Smith, Gajendra Shrestha, Stephen R. Piccolo, Mary Kay Harper, Ryan M. Van Wagoner, Zhenyu Lu, Ashlee R. Venancio, Chris M. Ireland, Andrea H. Bild, Philip J. Moos

Faculty Publications

Patients diagnosed with basal-like breast cancer suffer from poor prognosis and limited treatment options. There is an urgent need to identify new targets that can benefit patients with basal-like and claudin-low (BL-CL) breast cancers. We screened fractions from our Marine Invertebrate Compound Library (MICL) to identify compounds that specifically target BL-CL breast cancers. We identified a previously unreported trisulfated sterol, i.e., topsentinol L trisulfate (TLT), which exhibited increased efficacy against BL-CL breast cancers relative to luminal/HER2+ breast cancer. Biochemical investigation of the effects of TLT on BL-CL cell lines revealed its ability to inhibit activation of AMP-activated protein kinase (AMPK) …

Male Fetal Sex Affects Uteroplacental Angiogenesis In Growth Restriction Mouse Model, Jessica F. Hebert, Jess A. Millar, Rahul Raghavan, Amie L. Romney, Jason Podrabsky, Monique Y. Rennie, Allison Felker, Perrie O'Tierney-Ginn, Mayu Morita, Elizabeth A. Dupriest, Terry K. Morgan

Biology Faculty Publications and Presentations

Abnormally increased angiotensin II activity related to maternal angiotensinogen (AGT) genetic variants, or aberrant receptor activation, is associated with small-for-gestational-age (SGA) babies and abnormal uterine spiral artery remodeling in humans. Our group studies a murine AGT gene titration transgenic (TG; 3-copies of the AGT gene) model, which has a 20% increase in AGT expression mimicking a common human AGT genetic variant (A[-6]G) associated with intrauterine growth restriction (IUGR) and spiral artery pathology. We hypothesized that aberrant maternal AGT expression impacts pregnancy-induced uterine spiral artery angiogenesis in this mouse model leading to IUGR. We controlled for fetal sex and fetal genotype …

Studies On The Wild Dichondra Repen Forst. In Southwest Of China, Yan Chen, Youmin Gan, Kunlei Wang, Ling Fei

IGC Proceedings (1977-2023)

No abstract provided.

Green Turf Quality And Evapotranspiration Rate In Summer Of Agrostis Stolonifera L. Cv. Yuexuan No. 1 In Guangzhou Area, P. Chen, X. L. Shi, P. Liu, Y. L. Zhou, A. Liu

IGC Proceedings (1977-2023)

No abstract provided.

Extending Arda: Mapping Beyond The Lord Of The Rings And Silmarillion, Stentor Danielson

Journal of Tolkien Research

The canonical maps by Christopher Tolkien from The Lord of the Rings and The Silmarillion cover only a small portion of the world of J.R.R. Tolkien's legendarium. In the years since their publication, many artists have been inspired to try to create maps of the entire world. In doing so, they have both curated the canonical information provided by Tolkien as well as engaged in their own sub-creation, drawing on geographical ideas from the primary world. This paper examines a broad set of fan-made maps of Arda to trace the lineages of their geographical conceptions and the principles behind their …

Bibliometric Of Feature Selection Using Optimization Techniques In Healthcare Using Scopus And Web Of Science Databases, Rahul Joshi, Harita Gadikta, Saneeka Kharat, Soumi Mandal, Kalyani Kadam, Anupkumar M. Bongale Dr., Siddhant Pandit

Library Philosophy and Practice (e-journal)

Feature selection technique is an important step in the prediction and classification process, primarily in data mining related aspects or related to medical field. Feature selection is immersive with the errand of choosing a subset of applicable features that could be utilized in developing a prototype. Medical datasets are huge in size; hence some effective optimization techniques are required to produce accurate results. Optimization algorithms are a critical function in medical data mining particularly in identifying diseases since it offers excellent effectiveness in minimum computational expense and time. The classification algorithms also produce superior outcomes when an objective function is …

Contribution Of The University Of Burdwan And Kalyani University During 2000-19: A Scientometrics Analysis, Subhodip Bid, Dr Sukumar Mandal

Library Philosophy and Practice (e-journal)

The present paper attempt to compare the contribution of two state universities of West Bengal i.e. University of Burdwan (BU) and University of Kalyani (KU) under different parameters like publication size, authorship pattern, degree of collaboration, subject, language, geographical distribution during the period 2000 to 2019 ( 20 years) by using Web of Science as a source database. The study revealed that both the universities have almost similar authorship pattern, citation distribution and prefer to publish articles in journals. The USA ranked top as the most favorite country for collaboration for both the universities.

Optimal Nonlinear Pid Speed Control Based On Harmony Search For An Electric Vehicle, Mohamed Shamseldin, Mohamed Abdel Ghany, Yahia Hendawey

Future Engineering Journal

the paper presents an efficient scheme for a Nonlinear PID (NPID) controller to improve the dynamic response of the Electric Vehicle (EV). The objective of the proposed controller is to track accurately the reference speed selected by the driver of the EV. A MATLAB/Simulink model is established and validated for the considered EV to study the system performance. The proposed NPID controller has been investigated by comparing it with the traditional PID controller. The optimal parameters of Both the NPID and PID controllers were obtained using the Harmony Search (HS) optimization technique based on a cost function. The desired rise …

Comparison Of Winter Cow Feeding Strategies On Offspring Carcass Characteristics And Meat Quality, Erin Gubbels, Christopher Schauer, Don Stecher, Donny Drolc, Robin Salverson, Adele Harty, Warren Rusche, Cody Wright, Kristi Cammack, Zachary Smith, J. Kyle Grubbs, Keith Underwood, Janna Block, Kenneth Olson, Amanda Blair

SDSU Beef Day 2021 Summary Publication

Objective
The objective of this research was to investigate effects of maternal prepartum dietary energy source (forage vs. concentrate) during mid and late gestation on carcass composition, and meat quality of offspring.
Study Description
Angus-based cows from 2 sources [n = 129 from SDSU (Experiment 1) and n = 70 from North Dakota State University (Experiment 2)] were stratified by body weight and age and placed into two treatment groups at a drylot facility during mid- and late-gestation: Concentrate (dams fed a concentrate-based diet) or Forage (dams fed a forage-based diet). Calves were finished and carcass data was collected. Striploins …

Nalfurafine Reduces Neuroinflammation And Drives Remyelination In Models Of Cns Demyelinating Disease, Lisa Denny, Afnan Al Abadey, Katharina Robichon, Nikki Templeton, Thomas E. Prisinzano, Bronwyn M. Kivell, Anne C. La Flamme

Pharmaceutical Sciences Faculty Publications

Objectives: Multiple sclerosis (MS) is a neurodegenerative disease characterised by inflammation and damage to the myelin sheath, resulting in physical and cognitive disability. There is currently no cure for MS, and finding effective treatments to prevent disease progression has been challenging. Recent evidence suggests that activating kappa opioid receptors (KOR) has a beneficial effect on the progression of MS. Although many KOR agonists like U50,488 are not suitable for clinical use because of a poor side-effect profile, nalfurafine is a potent, clinically used KOR agonist with a favorable side-effect profile.

Methods: Using the experimental autoimmune encephalomyelitis (EAE) model, the effect …

Ketchikan Cup O'News 2021-01, Kathleen Wiechelman, John Long, Michelle Lampton

Ketchikan Cup O' News

No abstract provided.

Alleviating Poverty And Managing Natural Resources Through Integrated Crop‐Livestock Systems Research In Western China, William D. Bellotti, Z. B. Nan, Y. Y. Shen, F. J. Hou, S. Pain, Lihua Li, Xiaoyan Wang

IGC Proceedings (1977-2023)

No abstract provided.

Simulating Options For Managing Seasonal And Annual Variations In Feed Supply Of Mixed Crop/Livestock Systems In Sub‐Tropical Australia, Lindsay W. Bell

IGC Proceedings (1977-2023)

No abstract provided.

Impact Of Preceding Cropping And Cutting Height On Stand Uniformity Of Corn, Souichiro Morita, Tsutomu Kanno, Shunji Kurokawa, S. Sato, Y. Yoshimura

IGC Proceedings (1977-2023)

No abstract provided.

Integrating Dual‐Purpose Wheat Crops Into Different Sheep Production Systems In Southern Australia: Impacts On Livestock, Economic Returns And Risk, Andrew D. Moore, H. Dove, W. M. Kelman

IGC Proceedings (1977-2023)

No abstract provided.

Intake And Nutritional Value Of Brachiaria Brizantha Cv. Marandu In A Silvopastoral System, Rogerio M. Mauricio, N. M. Rodriguz, L. F. Sousa, E. O. S. Saliba, L. C. Gonçalves, G. R. Moreira

IGC Proceedings (1977-2023)

No abstract provided.

Text Mining Of Biomedical Literature: Discovering New Knowledge, Saikat Goswami, Sourav Mazumder, Sumana Chakrabarty

Library Philosophy and Practice (e-journal)

Biomedical literature is increasing day by day. The present scenario shows that the volume of literature regarding “coronavirus” has expanded at a high rate. In this study, text mining technique has been employed to discover something new from the published literature. The main objectives of this study are to show the growth of literature (Jan-Jun, 2020), extract document section, identify latent topics, find the most frequent word, represent the bag of words, and the hierarchical clustering. We have collected 16500 documents from PubMed. This study finds most number of documents (11499) belong to May and June. We explore …

Diabetes Prediction Using Machine Learning : A Bibliometric Analysis, Vijayshri Nitin Khedkar, Sina Patel

Library Philosophy and Practice (e-journal)

Diabetes Mellitus is a chronic disease which can be deadly if undetected for longer time. Artificial intelligence is helping in healthcare industry to a great extent by helping professionals to derive useful information and patterns from data available in various formats: Survey data, electronic health records, laboratory data.. Diabetes, if predicted at an early stage can help many people to save lives and cost for healthcare. Decision-making, diagnosing and predicting diabetes have become an increasing trend in recent years. There are numerous publications in diabetes prediction and yet it’s an ongoing research topic with availability of new data and methods. …

Salt Tolerance Of Some New Selections Of Warm Season Turfgrasses And Their Salt Tolerance Mechanisms, Jingbo Chen, Tingting Zhang, Jun Yan, Yanqin Jiang, Hailin Guo, Jianxiu Liu

IGC Proceedings (1977-2023)

No abstract provided.

Evaluating Turfgrass Color Using Hyperspectral Vegetation Indices, Gong Chen, W. Zhang, G. D. Li

IGC Proceedings (1977-2023)

No abstract provided.

Exploitation Enhancement Of Buffaloes Manure Application Vs Conventional Cultivation In Intensive Two Forage Cropping Models Per Year--Results On Agronomic Purposes, Pasquale Martiniello, E. Sabia, E. Rossi, S. Concetti

IGC Proceedings (1977-2023)

No abstract provided.

The Impact Of A Wide-Spread Insect Outbreak And Subsequent Timber Harvesting On Forested Rangelands, Matthew D. Braun

IGC Proceedings (1977-2023)

No abstract provided.

From Forages To Perennial Grain Polycultures: Illinois Bundleflower‐Intermediate Wheatgrass Dual Purpose Mixtures, V. D. Picasso, E. C. Brummer, M. Liebman

IGC Proceedings (1977-2023)

No abstract provided.

Itraq-Based Proteomic Analysis Of Bovine Pre-Ovulatory Plasma And Follicular Fluid, P A. Afedi, E L. Larimore, R A. Cushman, D Raynie, G A. Perry

Roman L. Hruska U.S. Meat Animal Research Center: Reports

Bovine follicular fluid (FF) creates a unique microenvironment in follicles necessary for follicle growth, oocyte maturation, and estradiol (E2) production. The objective of this study was to analyze changes in proteins in FF and plasma (PL) from animals with high E2 (HE2) or low E2 (LE2) during the preovulatory period. Beef cows were synchronized, and follicular dynamics and ovulatory response were monitored using transrectal ultrasonography. Nine cows were selected and slaughtered, blood samples were collected at slaughter and FF was aspirated from dominant follicles (DF; >10 mm). Abundant proteins (albumin, IgG, IgA, and alpha-1-antitrypsin) were depleted from both PL and …

23-Valent Polysaccharide Vaccine (Ppsv23)-Targeted Serotype-Specific Identification Of Streptococcus Pneumoniae Using The Loop-Mediated Isothermal Amplification (Lamp) Method, Jiwon Lee, Youngbae Yoon, Eun Jin Kim, Donghyun Lee, Yeoungjun Baek, Chika Takano, Bin Chang, Takahiro Iijima, Paul E. Kilgore, Satoshi Hayakawa, Tomonori Hoshino, Dong Wook Kim, Mitsuko Seki

Department of Pharmacy Practice

Reports of invasive disease due to Streptococcus pneumoniae have declined since the introduction of pneumococcal conjugate vaccines (PCV7 and PCV13). The incidence of invasive diseases due to S. pneumoniae that are not addressed by the vaccines, however, has increased in children and adults, creating a global public health problem. Previously, we established the loop-mediated isothermal amplification (LAMP) method for a PCV13 serotype-specific assay. In the current study, we developed a rapid, simple, and cost-effective assay to detect serotypes in the 23-valent pneumococcal polysaccharide vaccine (PPSV23) using the LAMP method. In this study, LAMP primer sets for serotypes 2, 8, 9N, …

Regulation Of Kv11.1 Isoform Expression By Polyadenylate Binding Protein Nuclear 1, Matthew R. Stump, Rachel T. Nguyen, Rachel H. Drgastin, Delaney Search, Quiming Gong, Zhengfeng Zhou

Faculty Publications - Department of Biological & Molecular Science

The Kv11.1 voltage-gated potassium channel, encoded by the KCNH2 gene, conducts the rapidly activating delayed rectifier current in the heart. KCNH2 pre-mRNA undergoes alternative polyadenylation to generate two C-terminal Kv11.1 isoforms in the heart. Utilization of a poly(A) signal in exon 15 produces the full-length, functional Kv11.1a isoform, while intron 9 polyadenylation generates the C-terminally truncated, nonfunctional Kv11.1a-USO isoform. The relative expression of Kv11.1a and Kv11.1a-USO isoforms plays an important role in the regulation of Kv11.1 channel function. In this study, we tested the hypothesis that the RNA polyadenylate binding protein nuclear 1 (PABPN1) interacts with a unique 22 nt …

A Bibliometric Analysis Of The Tea Quality Evaluation Using Artificial Intelligence, Amruta Bajirao Patil Research Scholar, Mrinal Rahul Bachute Ph.D Guide And Associate Professor

Library Philosophy and Practice (e-journal)

ABSTRACT: In this study, we have carried the bibliometric review of the “Tea quality evaluation using artificial intelligence”. Only the Scopus database is under consideration for this analysis. To coat all possible research approaches here we have generated the valid search queries which excludes irrelevant literature. The result analysis shows overall 602 useful papers are available on the tea quality evaluation out of which 12 papers are specifically on artificial taste perception of tea. This survey illustrates the emerging trend of quality evaluation and assurance (QEA) in tea industry and its importance. As the production of tea is huge, storage …

A High Affinity, Partial Antagonist Effect Of 3,4-Diaminopyridine Mediates Action Potential Broadening And Enhancement Of Transmitter Release At Nmjs, Kristine S Ojala, Scott P Ginebaugh, Man Wu, Evan W Miller, Gloria Ortiz, Manuel Covarrubias, Stephen D Meriney

Department of Neuroscience Faculty Papers

3,4-Diaminopyridine (3,4-DAP) increases transmitter release from neuromuscular junctions (NMJs), and low doses of 3,4-DAP (estimated to reach ∼1 μM in serum) are the Food and Drug Administration (FDA)-Approved treatment for neuro muscular weakness caused by Lambert-Eaton myasthenic syn drome. Canonically, 3,4-DAP is thought to block voltage-gated potassium (Kv) channels, resulting in prolongation of the pre synaptic action potential (AP). However, recent reports have shown that low millimolar concentrations of 3,4-DAP have an off-Target agonist effect on the Cav1 subtype ("L-Type") of voltage-gated calcium (Cav) channels and have speculated that this agonist effect might contribute to 3,4-DAP effects on transmitter release …

3d-Printed Microfluidic Droplet Generator With Hydrophilic And Hydrophobic Polymers, Chandler A. Warr, Hunter S. Hinnen, Saroya Avery, Rebecca J. Cate, Gregory P. Nordin, William G. Pitt

Faculty Publications

Droplet generation has been widely used in conventional two-dimensional (2D) microfluidic devices, and has recently begun to be explored for 3D-printed droplet generators. A major challenge for 3D-printed devices is preventing water-in-oil droplets from sticking to the interior surfaces of the droplet generator when the device is not made from hydrophobic materials. In this study, two approaches were investigated and shown to successfully form droplets in 3D-printed microfluidic devices. First, several printing resin candidates were tested to evaluate their suitability for droplet formation and material properties. We determined that a hexanediol diacrylate/lauryl acrylate (HDDA/LA) resin forms a solid polymer that …

[(Wr)8Wkβa]-Doxorubicin Conjugate: A Delivery System To Overcome Multi-Drug Resistance Against Doxorubicin, Khalid Zoghebi, Hamidreza Montazeri Aliabadi, Rakesh Kumar Tiwari, Keykavous Parang

Pharmacy Faculty Articles and Research

Doxorubicin (Dox) is an anthracycline chemotherapeutic agent used to treat breast, leukemia, and lymphoma malignancies. However, cardiotoxicity and inherent acquired resistance are major drawbacks, limiting its clinical application. We have previously shown that cyclic peptide [WR]₉ containing alternate tryptophan (W) and arginine (R) residues acts as an efficient molecular transporter. An amphiphilic cyclic peptide containing a lysine (K) residue and alternative W and R was conjugated through a free side chain amino group with Dox via a glutarate linker to afford [(WR)₈WKβA]-Dox conjugate. Antiproliferative assays were performed in different cancer cell lines using the conjugate and the …