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Elucidation Of The Cellular Mechanisms Underlying Missense Mutations In Low Density Lipoprotein Receptor Related Protein 6 (Lrp6) Associated With Cardiovascular Diseases, Huda Issa Samha

Theses

Low-density Lipoprotein Receptor Related Protein 6 (LRP6) is a member of the Low-Density Lipoprotein Receptors family (LDLRs) which is involved in the clearance of LDL from the bloodstream and the signaling of the canonical wingless signaling pathway. Several genetic variants in the LRP6 gene have been conclusively associated with cardiovascular diseases (CVDs) and metabolic syndrome. However, the structural and functional implications of those variations have not been fully elucidated. The CVD-associated LRP6 variants could be retained and possibly subjected to Endoplasmic Reticulum Associated Degradation (ERAD), a quality control and adaptive process employed by cells to eliminate misfolded proteins to maintain …

Thrombosis With Thrombocytopenia Syndrome After Administration Of Azd1222 Or Ad26.Cov2.S Vaccine For Covid-19: A Systematic Review, Usama Waqar, Shaheer Ahmed, Syed M H Ali Gardezi, Muhammad Sarmad Tahir, Zain Ul Abidin, Ali Hussain, Natasha Bahadur Ali, Syed Faisal Mahmood

Medical College Documents

Background: Cases of thrombosis with thrombocytopenia syndrome (TTS) have been reported following vaccination with AZD1222 or Ad26.COV2.S. This review aimed to explore the pathophysiology, epidemiology, diagnosis, management, and prognosis of TTS.
Methods: A systematic review was conducted to identify evidence on TTS till 4th September 2021. Case reports and series reporting patient-level data were included. Descriptive statistics were reported and compared across patients with different sexes, age groups, vaccines, types of thrombosis, and outcomes.
Findings: Sixty-two studies reporting 160 cases were included from 16 countries. Patients were predominantly females with a median age of 42.50 (22) years. AZD1222 was administered …

Development And Validation Of A Basic Ground Skills Assessment For Equine-Assisted Services, Sarah J. Andersen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The equine-assisted services program at Utah State University produced and validated an assessment process used to test equines for suitability for equine-assisted services. Equine-assisted services incorporate the interaction of humans who face mental, physical, emotional, and/or social challenges and equines for therapeutic purposes. Recreational, physical, mental, social, and/or emotional goals are met through various equine-assisted services such as therapies, equine-assisted learning, and horsemanship.

Due to the potential for human injury while interacting with equines, it is important to ensure equines are assessed for safe behavior prior to participation in equine-assisted services. This is why our group developed and tested the …

Assessing Parental Involvement In Required High School Financial Literacy Education Courses Taught In Utah School Districts, Jennifer L. Gardner

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Financial management skills are used throughout our lives, from the first allowance we receive until we provide funds for our funeral services and burial. How do we learn financial skills that last us a lifetime?

Much of our learning comes from watching others, specifically as children and teens, even into young adulthood, as explained by Social Learning Theory. This informal learning can help or hinder us throughout our lives, especially when finances are involved. In recent years, the opportunities for formal education have increased.

Ideally, based on systems theory, formal and informal financial learning would work hand in hand for …

Immobilized Lipase On Zif For Enhanced Biofuel Production, Reem Mohammed Al Mansouri

Theses

Enzymatic transesterification of triglycerides to produce biodiesel has been gaining increasing attention owing to its advantages over chemical processes. Being catalysts, enzymes are not consumed during the processes in which they are used. Therefore, a successful technique to allow their repeated use can significantly enhance the economic feasibility of the process. The most common approach to allow easy separation of the enzymes and to eliminate their wastage is immobilization on a support matrix. Recently, Metal-Organic Frameworks (MOFs) have been suggested as preferable support for enzyme immobilization, owing to their high-order structure and high porosity and specific surface area. This thesis …

The Impact Of Wastewater Chemistry And Flow Characteristics On Hydrogen Sulfide Concentration, Mohsina Muhammed Sherief

Theses

Hydrogen sulfide (H₂S) is a naturally occurring, highly toxic gas that is formed from the decomposition of sulfur compounds. At low concentrations, H₂S is an irritant for the eyes, respiratory and gastrointestinal tract. At higher H₂S concentrations, it produces neurological impairment with dizziness, headache, and loss of consciousness. Mortality was reported to reach 6 percent following exposure to elevated concentrations. H₂S is generated in different industrial processes. In wastewater collection and treatment plants, H₂S is a common source of concrete and metal corrosion that has resulted in huge economic loss. …

Flow Of Quantum Genetic Lotka-Volterra Algebras On M2(ℂ), Sondos Muhammed Syam

Theses

In this thesis, a class of flow quantum Lotka-Volterra genetic algebras (FQLVG-A) is investigated and its structure is studied. Moreover, the necessary and sufficient conditions for the associativity and alternatively of FQGLV-A are derived. In addition, idempotent elements in FQGLV-A are found. Also, derivations of a class of FQLVG-A are described. Also, the automorphisms of a class of FQLVG-A and their positivity are examined.

The Impact Of Moral Injury And Moral Distress On Spirituality From A Military Perspective, Emily Sproule

Dissertations

The purpose of this study was to gain greater insight and understanding of how moral injury, moral distress, and shame can influence spirituality and to determine ways to effectively improve treatment to support and serve those carrying these unspeakable wounds. The experience of loss, betrayal, uncertainty, and fractured spirits can affect an individual’s beliefs about the self. The primary aim of this study was to explore how veterans now view themselves in the eyes of God or their Higher Power or why they so choose not to partake in their spirituality. Results were based on aggregate analyses and summations of …

Computational Design Of Β-Fluorinated Morphine Derivatives For Ph-Specific Binding, Makena Augenstein, Nayiri Alexander, Matthew Gartner

Student Scholar Symposium Abstracts and Posters

Molecular extension and dissection techniques are used to design a morphine derivative that promotes selective binding in inflamed tissue due to its lower pH while avoiding dangerous activation in the brain. Morphine is used to treat pain associated with inflammation. While being effective analgesics, opioids carry the risk of central side effects, including addiction, respiratory depression, and sedation. Opioids are agonists that bind to the μ-opioid peptide receptor (MOR) within central and peripheral nerves and act via a G-protein coupled receptor pathway.

Deprotonation of the tertiary amine induces a negative charge on the nitrogen, discouraging binding at physiological pH (pH=7.4). …

Use Patterns And Influencing Factors Of Irrigation Best Management Practices In The Lower Mississippi River Basin, Merri E. Day

Graduate Theses and Dissertations

This study uses the 2016 Irrigation Survey from Arkansas, Louisiana, and Mississippi to document the use of irrigation best management practices (IBMPs), analyze use patterns, and use quantitative methods to determine factors that influence producers’ decisions regarding IBMPs. IBMPs included in the survey can be grouped as: field management practices (zero-grade leveling, precision-grade leveling, end blocking, warped surface, and deep tillage), water flow control practices (computerized pipe-hole selection, multiple-inlet irrigation, surge irrigation, alternate wetting and drying, cutback irrigation, flow meters, and pump timers), water recovery/storage practices (tail-water recovery system and on-farm storage reservoir), and advanced irrigation scheduling practices (soil moisture …

Tissue Engineering And The Effect Of Volumetric Muscle Loss On Muscle Performance, Alex Pemberton

Biomedical Engineering Undergraduate Honors Theses

Trauma, for so many people, creates life altering injuries. One of the major injuries that results from trauma is volumetric muscle loss (VML), which is the loss of muscle tissue that cannot be naturally regenerated and results in chronic loss of function. When a small amount of damage is done to a muscle, but the underlying extracellular matrix of the cell is still intact, the muscle can regenerate much of its volume and function. If the injury damages the extracellular matrix, the injury site is instead filled with scar tissue, which cannot regenerate muscle mass or function. Seen widely in …

Lawyering 'Twisties': Naming And Untangling Performance Anxiety, Heidi K. Brown

Faculty Scholarship

No abstract provided.

Integrating Multiple Survey Techniques To Document A Shifting Bat Community In The Wake Of White-Nose Syndrome, D. Scott Reynolds, Kevin Shoemaker, Susi Von Oettingen, Stephen Najjar, Jacques P. Veilleux, Paul R. Moosman Jr

KIP Articles

The long-term study of bat communities often depends on a diverse set of sampling methodologies that are chosen based on the species or habitat management priorities of the research project. Integrating the data from a diverse set of methodologies (such as acoustic monitoring and mist net sampling) would improve our ability to characterize changes in community structure or composition over time, such as one would expect following an emergent infectious disease such as white-nose syndrome. We developed a Bayesian state-space model to integrate these disparate data into a common currency (relative abundance). We collected both acoustic monitoring and mist net …

Investigating The Role Of The Skeletal Muscle In Amyotrophic Lateral Sclerosis Neuromuscular Junction Dysfunction, Agnes Badu-Mensah

Electronic Theses and Dissertations, 2020-2023

Neuromuscular junction (NMJ) dysfunction has been identified as one of the earliest events in Amyotrophic Lateral Sclerosis (ALS) pathology. However, which tissue type induces NMJ disruption; be it the motoneurons (hMN), Schwann cells or skeletal muscle (hSKM) remains unresolved. While mechanisms by which ALS hMN contribute to NMJ dysfunction are well-described in literature, limited information exist on how the other tissue types in the tripartite synapse (hSKM and Schwann cells) induce and/or contribute to ALS NMJ disruption. A fair understanding of the role of each tissue type in NMJ dysfunction would help shape the trajectory of future ALS research and …

December 1, 2021 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Map-Gan: Unsupervised Learning Of Inverse Problems, Brandon S. Campanella

Master's Theses

In this paper we outline a novel method for training a generative adversarial network based denoising model from an exclusively corrupted and unpaired dataset of images. Our model can learn without clean data or corrupted image pairs, and instead only requires that the noise distribution is able to be expressed analytically and that the noise at each pixel is independent. We utilize maximum a posteriori estimation as the underlying solution framework, optimizing over the analytically expressed noise generating distribution as the likelihood and employ the GAN as the prior. We then evaluate our method on several popular datasets of varying …

Agents Of Bioshield: The Fda, Emergency Use Authorizations, And Public Trust, Kirstiana Perryman

Georgia Law Review

The SARS-CoV-2 pandemic spurred the U.S. Food & Drug Administration (FDA) to utilize the Emergency Use Authorization (EUA) procedure more than ever before. The pandemic pushed the relatively obscure procedure into public consciousness, making it a frequent topic of discussion and debate. The EUA procedure permits the FDA Commissioner to authorize the introduction of drugs, devices, or biological products into interstate commerce for use in an actual or potential emergency. To issue an authorization, the FDA Commissioner must determine that it is “reasonable to believe,” based on the “totality of the evidence,” that the product “may be effective.” This standard …

Paleogenomics Illuminates The Evolutionary History Of The Extinct Holocene “Horned” Crocodile Of Madagascar, Voay Robustus, E. Hekkala, J. Gatesy, A. Narechania, R. Meredith, M. Russello, M. L. Aardema, E. Jensen, S. Montanari, C. Brochu, M. Norell, G. Amato

Department of Biology Faculty Scholarship and Creative Works

Ancient DNA is transforming our ability to reconstruct historical patterns and mechanisms shaping modern diversity and distributions. In particular, molecular data from extinct Holocene island faunas have revealed surprising biogeographic scenarios. Here, we recovered partial mitochondrial (mt) genomes for 1300–1400 year old specimens (n = 2) of the extinct “horned” crocodile, Voay robustus, collected from Holocene deposits in southwestern Madagascar. Phylogenetic analyses of partial mt genomes and tip-dated timetrees based on molecular, fossil, and stratigraphic data favor a sister group relationship between Voay and Crocodylus (true crocodiles). These well supported trees conflict with recent morphological systematic work that has consistently …

Local Weather Explains Annual Variation In Northern Goshawk Reproduction In The Northern Great Basin, Usa, Allyson B. Bangerter, Eliana R. Heiser, Jay D. Carlisle, Robert A. Miller

Intermountain Bird Observatory Publications and Presentations

Weather is thought to influence raptor reproduction through effects on prey availability, condition of adults, and survival of nests and young; however, there are few long-term studies of the effects of weather on raptor reproduction. We investigated the effects of weather on Northern Goshawk (Accipiter gentilis; henceforth goshawk) breeding rate, productivity, and fledging date in south-central Idaho and northern Utah, USA. Using data from 42 territories where we found evidence of breeding attempts in ≥1 yr from 2011–2019, we analyzed breeding rates using 315 territory–season combinations, analyzed productivity for 134 breeding attempts, and analyzed fledging date for 118 …

Boise State Magazine, Anna Webb (Editor)

FOCUS on Boise State

No abstract provided.

Childhood Sexual Abuse Disclosure And Mental Health Outcomes: The Relationship Between Gender, Parental Style, And Masculinity Norms, Kayla E. Hall

USC Aiken Psychology Theses

Objective: The current study aims to investigate social reactions to childhood sexual abuse disclosure (CSA) in adult men and women. Additionally, the study explores the relationship between conformity to masculinity norms and perception of parental style on timing of disclosure and resulting internalizing and externalizing symptoms and substance abuse.

Method: Using Amazon’s Mechanical Turk, 299 adult men and women residing in the U.S. (M_age = 35.9, SD_age= 10.5; 53% female; 78% European American) completed an anonymous online series of survey items pertaining to childhood sexual abuse, internalizing and externalizing mental health symptoms, substance abuse, social reactions …

International Society Of Sports Nutrition Position Stand: Caffeine And Exercise Performance, Nanci S. Guest, Trisha A. Vandusseldorp, Michael T. Nelson, Jozo Grgic, Brad J. Schoenfeld, Nathaniel D.M. Jenkins, Shawn M. Arent Ph.D., Cscs*D, Fissn, Facsm, Fnak, Jose Antonio, Jeffrey R. Stout, Eric T. Trexler, Abbie E. Smith-Ryan, Erica R. Goldstein, Douglas S. Kalman, Bill I. Campbell

Faculty Publications

Following critical evaluation of the available literature to date, The International Society of Sports Nutrition (ISSN) position regarding caffeine intake is as follows:1.Supplementation with caffeine has been shown to acutely enhance various aspects of exercise performance in many but not all studies. Small to moderate benefits of caffeine use include, but are not limited to: muscular endurance, movement velocity and muscular strength, sprinting, jumping, and throwing performance, as well as a wide range of aerobic and anaerobic sport-specific actions.2.Aerobic endurance appears to be the form of exercise with the most consistent moderate-to-large benefits from caffeine use, although the magnitude of …

Siderophore-Mediated Zinc Acquisition Enhances Enterobacterial Colonization Of The Inflamed Gut, Judith Behnsen, Hui Zhi, Allegra T. Aron, Venkateswaran Subramanian, William Santus, Michael H. Lee, Romana R. Gerner, Daniel Petras, Janet Z. Liu, Keith D. Green, Sarah L. Price, Jose Camacho, Hannah Hillman, Joshua Tjokrosurjo, Nicola P. Montaldo, Evelyn M. Hoover, Sean Treacy-Abarca, Benjamin A. Gilston, Eric P. Skaar, Walter J. Chazin, Sylvie Garneau-Tsodikova, Matthew B Lawrenz, Robert D Perry, Sean-Paul Nuccio, Pieter C. Dorrestein, Manuela Raffatellu

Pharmacy Nuclear Magnetic Resonance Center Faculty Publications

Zinc is an essential cofactor for bacterial metabolism, and many Enterobacteriaceae express the zinc transporters ZnuABC and ZupT to acquire this metal in the host. However, the probiotic bacterium Escherichia coli Nissle 1917 (or “Nissle”) exhibits appreciable growth in zinc-limited media even when these transporters are deleted. Here, we show that Nissle utilizes the siderophore yersiniabactin as a zincophore, enabling Nissle to grow in zinc-limited media, to tolerate calprotectin-mediated zinc sequestration, and to thrive in the inflamed gut. We also show that yersiniabactin’s affinity for iron or zinc changes in a pH-dependent manner, with increased relative zinc binding as the …

Glycan Functionalization Of Iron Oxide Nanoparticles (Ionps) As A Method Of Inactivating Antibiotic Resistant Neisseria Gonorrhoeae Via A Magnetically Mediated Energy Delivery (Magmed) System, Cedric Taylor

All Theses

With the increase of antibiotic resistant bacteria, current established therapeutic treatment methods are rapidly demonstrating decreasing efficacy. For this project, we are studying a novel alternate mechanism of treating antibiotic resistant bacteria by utilizing magnetic iron oxide nanoparticles (IONPs) coated with a heterobifunctional polyethylene glycol polymer (PEG) and functionalized with glycan structures that can interact with Neisseria gonorrhoeae FA1090. Interaction between the IONPs and bacteria is manipulated by an external alternating magnetic field (AMF) in a process known as magnetically mediated energy delivery (MagMED). Magnetic IONPs were synthesized and reacted with PEG (PEG-IONPs) and functionalized with glycans Gal(α1-3)Gal(β1-4)Glc(β1-1) (common name: …

Unmet Needs In Adolescents And Young Adults With Cancer: A Mixed-Method Study Using Social Media, Eunju Choi

Sigma Foundation for Nursing Research Grant Reports

The purpose of this study is to identify and compare the unmet needs of adolescents and young adults (AYAs) with cancer by age and gender.

Music Listening And Cognitive Function, Neil Kotta

Honors Theses

No abstract provided.

The Investigations Of Nps Modulated Immunity And Immunometabolism, Brittney Leigh Ruedlinger

Biomedical Sciences Theses & Dissertations

Cancers remain in the top noncommunicable diseases responsible for premature mortality. The heterogeneity among cancers and within tumors makes treating them ever more challenging. Our misfortune for developing cures is mocked by cancer, with the lowest probability of success (PoS) through clinical trials and FDA approval. At the basic level, there are generally two broad gaps impeding cancer eradication: the unidentified shared mechanism(s) exploited by all cancers and the therapeutic approach to intervene. Nanosecond pulse stimulation (NPS) offers a unique approach since its broad impacts intersect those often hijacked by oncogenesis. Metabolic pathways, known for dysfunctions among cancers, share a …

Assessment Of The Hydrograv® Adapt Variable Height Secondary Clarifier Inlet At Hrsd Nansemond Treatment Plant, Matthew Poe

Civil & Environmental Engineering Theses & Dissertations

The Hampton Roads Sanitation District (HRSD) recently completed the first North American and center driven installation of the Hydrograv® Adapt Variable Height Secondary Clarifier Inlet (Adapt) at HRSD’s Nansemond Treatment Plant. This is a variable height inlet structure designed to decrease clarifier effluent turbidity and maintain low turbidity during high flow events. Low turbidity is achieved by feeding the secondary clarifier influent within the solids blanket during dry weather conditions and lifting the inlet structure during wet weather conditions to avoid disrupting the blanket. The Adapt clarifier was monitored alongside an identical fixed inlet clarifier to assess performance. Both clarifiers …

Tunable Compressive Mechanical Behavior Of Ice-Templated Materials, Sashanka Akurati

Mechanical & Aerospace Engineering Theses & Dissertations

The inherent hierarchical microstructural organization in natural materials is responsible for their excellent mechanical properties beyond that predicted by the simple rule-of-mixtures. Further exhibit synergy between strength and toughness, otherwise mutually exclusive in brittle materials. Conventional processing methods are unable to replicate hierarchical microstructures in engineering ceramics akin to that observed in natural materials. Ice-templating has emerged as a potential technique to fabricate bioinspired hierarchical materials. This process involves simultaneous unidirectional solidification and phase segregation of aqueous suspensions. Ice-templated porous ceramic materials have received significant attention for overcoming several limitations of conventional ceramic foams currently used in numerous engineering applications. …

Intention-Behavior Discrepancies For Alcohol Consumption Among College Students, Emily Kaye Junkin

Psychology Theses & Dissertations

Unplanned drinkers may experience elevated risk for drinking-related harm. Research examining unplanned drinking focuses on the unplanned nature of a drinking episode (i.e., did the student drink when no drinking was planned), yet this does not capture the importance of the unintended quantity consumed. For instance, a discrepancy between drinking intentions and actual consumption has the potential to differentially impact alcohol-related outcomes beyond what is accounted for by unplanned drinking episodes. Further, research has not investigated how college students’ unintended drinking is associated with alcohol-related consequences. Moreover, utilization of protective behavioral strategies (PBS) has been shown to decrease negative outcomes …