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Subjective Age And Inflammation Risk In Midlife Adults: Findings From The Midlife In The United States (Midus) Studies, Andree Hartanto, Nadyanna M. Majeed, Wee Qin Ng, Colin Kai Ning Chai, Verity Yu Qing Lua

Research Collection School of Social Sciences

Recent studies have suggested that subjective age—a subjective evaluation of one's own age—is a promising construct in gerontology that may contribute our understanding of risk for immune dysfunction. Nevertheless, studies documenting the association between subjective age and inflammatory biomarkers remain limited and provide mixed findings. In the present study, we revisited the relation between subjective age and systemic inflammation by utilizing a range of well-established inflammatory biomarkers (C-reactive protein, interleukin-6, fibrinogen, E-selectin, and intercellular adhesion molecule 1) through the collection of fasting blood samples before breakfast. In a large-scale dataset of midlife adults (N = 1800), we found some evidence …

Beyond The "Formidable Circle": Race And The Limits Of Democratic Inclusion In Tocqueville's Democracy In America, Christine Dunn Henderson

Research Collection School of Social Sciences

Despite his assertion that the first volume of Democracy in America (1835) would concentrate upon institutions, Tocqueville found himself finishing the draft manuscript in 1834 and unable to conclude his study without discussing race relations in the United States. In the end, he quickly penned a final chapter. That chapter—by far the book’s longest—offers “Some Considerations on the Present State and Probable Future of the Three Races That Inhabit the Territory of the United States.” Tocqueville begins the chapter by acknowledging that its subject “is American without being democratic” (DA, p. 516), and to the extent that it analyzes slavery …

The Effect Of Sub 5% Oxygen Tension On In Vitro Human Embryo Development, Bradley James Link

EVMS School of Health Professions Theses & Dissertations

Objective: To determine the impact of < 5% O₂ tension on the in vitro development of human pre-implantation embryos. It was hypothesized that the optimal O₂ tension would differ from the commonly utilized 5%, as shown by beneficial effects after the implementation of a more physiological O₂ tension such as 2% for either the partial or full duration of in vitro culture.

Aim: To conduct a randomized controlled study to determine the effect of O₂ tension during in vitro human embryo culture on the production of reactive oxygen species (ROS), apoptosis, gene expression and embryo development.

Background: The …

The Effects Of Prescribed Burning On Soil Water Infiltration Rates And Other Select Soil Physical And Chemical Properties In East Texas, Cassady Pennington Dunson, Brian P. Oswald, Kenneth Farrish, Tyson Hart

Electronic Theses and Dissertations

This study focused on whether prescribed burning affects soil physical and chemical properties, especially water infiltration, in Western Gulf Coast forests. Soil water infiltration rates were measured 1) pre-burn (before the fire), 2) post-burn (one month after the fire), and 3) at vegetation green-up (three months after the fire). Soil samples were also collected to determine the effects of prescribed burning on soil pH, bulk density, particle density, pore space, soil strength, O-horizon weight and depth (organic matter), water stable aggregates, and soil fertility. This project was conducted on two different burn intervals. The National Forests and Grasslands of Texas …

Evaluating The Contributions Of Recollection And Familiarity On Testing And Guessing Benefits In Recognition Memory, Kendal Smith

Dissertations

Completing an interpolated memory test or trying to guess non-studied information following study has yielded powerful memory benefits relative to restudy on a final memory test. Across repetitions of testing and guessing, participants may form an expectancy of an upcoming test type, and consequently, adjust their encoding of information in anticipation of the upcoming test. Research has shown that after several task repetitions, participants form an expectancy of the upcoming task type and will encode materials to match task constraints (Huff, Yates, and Balota, 2018). It is uncertain to what extent these expectancy processes aid in facilitating recollection of specific …

Design Of New Azole Molecules To Prevent Metal Leaching From Medical Implants, Ronan Mcateer

Masters

The aim of this project was to develop new coatings for titanium based implants, most particularly stents, incorporating heterocyclic functional groups in their structure that will have the potential to bind to a titanium surface and prevent or reduce metal corrosion. Many of the current coatings are chemically bound onto metallic surfaces, but this project looks at electropolymerising the coatings onto the surface of the Ti6Al4V stents. Hence, polymerising functional groups have been incorporated with azoles in the structure of the synthesised compounds. Additionally, surface characterisation and preliminary corrosion studies have been carried out on a series of coated TI6Al4V …

Effect Of Ultrasound Pressure On The Distribution Of Bovine Serum Albumin Delivered By Focused Ultrasound-Mediated Blood-Brain Barrier Opening In Cleared Mouse Brains, Yajie Liu

McKelvey School of Engineering Graduate Student Theses & Dissertations

Most common diagnosis and therapeutic methods have low effectiveness when used on brain diseases. The key obstacle is that the blood-brain barrier (BBB) prevents most drugs from entering the brain. Some strategies have been developed to improve the efficiency of drug delivery crossing BBB. Among all these strategies, focused ultrasound-mediated BBB opening (FUS-BBB Opening) stands out since it is noninvasive and can be located to the target area. Detailed studies are required on the distribution of drugs delivered by FUS-BBB opening and the effects of FUS parameters on the distribution. This thesis proposes a pipeline involving tissue clearing and lightsheet …

Double-Blind Randomized Proof-Of-Concept Trial Of Canakinumab In Patients With Covid-19 Associated Cardiac Injury And Heightened Inflammation, Paul C Cremer, Calvin C Sheng, Debasis Sahoo, Siddharth Dugar, Robier Aguillon Prada, Tom Kai Ming Wang, Ossama K Abou Hassan, Jamie Hernandez-Montfort, David A Wolinsky, Daniel A Culver, Prabalini Rajendram, Abhijit Duggal, Danielle M Brennan, Katherine E Wolski, A Michael Lincoff, Steven E Nissen, Venu Menon

Faculty, Staff and Student Publications

AIMS: In coronavirus disease 2019 (COVID-19), myocardial injury is associated with systemic inflammation and higher mortality. Our aim was to perform a proof of concept trial with canakinumab, a monoclonal antibody to interleukin-1β, in patients with COVID-19, myocardial injury, and heightened inflammation.

METHODS AND RESULTS: This trial required hospitalization due to COVID-19, elevated troponin, and a C-reactive protein concentration more than 50 mg/L. The primary endpoint was time to clinical improvement at Day 14, defined as either an improvement of two points on a seven-category ordinal scale or discharge from the hospital. The secondary endpoint was mortality at Day 28. …

Psychedelic Drugs And Atheism: Debunking The Myths, Wayne Glausser

English Faculty publications

Two recent surveys of people who took psychedelic drugs and reported “God experience encounters”, along with successful clinical trials using psychedelic therapy for depression, have given rise to public misconceptions about psychedelics and atheism. Specifically, three inferences have been drawn: (1) that the psychedelic experience tends to dissolve atheist convictions; (2) that atheist convictions, once dissolved, are replaced with traditional monotheist beliefs; and (3) that atheism and depression somehow correlate as afflictions for which psychedelic drugs offer relief. This paper argues, based on analysis of the studies and trials along with relevant supplemental evidence, that each of these popular inferences …

Lipocalin 2 Promotes Inflammatory Breast Cancer Tumorigenesis And Skin Invasion, Emilly S. Villodre, Xiaoding Hu, Richard Larson, Pascal Finetti, Kristen Gomez, Wintana Balema, Shane R. Stecklein, Ginette Santiago-Sanchez, Savitri Krishnamurthy, Juhee Song

Health & Biomedical Sciences Faculty Publications

Inflammatory breast cancer (IBC) is an aggressive form of primary breast cancer characterized by rapid onset and high risk of metastasis and poor clinical outcomes. The biological basis for the aggressiveness of IBC is still not well understood and no IBC-specific targeted therapies exist. In this study, we report that lipocalin 2 (LCN2), a small secreted glycoprotein belonging to the lipocalin superfamily, is expressed at significantly higher levels in IBC vs non-IBC tumors, independently of molecular subtype. LCN2 levels were also significantly higher in IBC cell lines and in their culture media than in non-IBC cell lines. High expression was …

Cosm Diversity & Inclusion Newsletter, Georgia Southern University

College of Science & Mathematics: News & Publications (2012-2022)

Welcome

The Diversity & Inclusion newsletter is delivered monthly via email during the fall and spring semesters and is always available on the new COSM D&I webpage. Send contributions and suggestions to any of the COSM D&I Ambassadors listed at the bottom of this newsletter and on the webpage.

Environmental Dna (Edna) Surveys For The Smalltooth Sawfish, Pristis Pectinata, In The Chandeleur Islands, Louisiana, Emma M. Humphreys

Honors Theses

The Critically Endangered smalltooth sawfish, Pristis pectinata, was historically found throughout tropical and subtropical coastal waters of the Atlantic Ocean. As a result of mortalities in fisheries and habitat degradation, they became largely restricted to southwest Florida in the U.S. and the Bahamas by the 1980s. However, recent public encounter reports of sawfish in the Florida panhandle, Mississippi, and Louisiana suggest this species is occasionally present in northern Gulf of Mexico waters. Targeted species surveys are needed to improve our understanding of the occurrence and status of this species in these waters. This research used environmental DNA (eDNA) methods …

Determination Of Temperature Thresholds For The Parasitoid Diachasmimorpha Longicaudata (Hymenoptera: Braconidae), Using Life Cycle Simulation Modeling: Implications For Effective Field Releases In Classical Biological Control Of Fruit Flies, Shepard Ndlela, Abdelmutalab G.A. Azrag, Samira A. Mohamed

All Peer-Reviewed Publications

The braconid parasitoid Diachasmimorpha longicaudata (Ashmead) (Hymenoptera: Braconidae) is one of the most important natural enemies in classical biological control programs against tephritid fruit flies worldwide. In light of the spread of the invasive fruit fly species, Bactrocera dorsalis in Africa and beyond, there is a need to implement classical biological control. The current study aimed to determine temperature thresholds for D. longicaudata reared on B. dorsalis, using life cycle simulation modeling to guide informed parasitoid releases in Africa. Simulated parameters included thermal requirements, population growth parameters at different temperature requirements, suitable areas for the establishment, and the number of …

Transmission Of ‘Candidatus Anaplasma Camelii’ To Mice And Rabbits By Camel-Specific Keds, Hippobosca Camelina, Joel L. Bargul, Kevin O. Kidambasi, Merid N. Getahun, Jandouwe Villinger, Robert S. Copeland, Jackson M. Muema, Mark Carrington, Daniel K. Masiga

All Peer-Reviewed Publications

Anaplasmosis, caused by infection with bacteria of the genus Anaplasma, is an important veterinary and zoonotic disease. Transmission by ticks has been characterized but little is known about non-tick vectors of livestock anaplasmosis. This study investigated the presence of Anaplasma spp. in camels in northern Kenya and whether the hematophagous camel ked, Hippobosca camelina, acts as a vector. Camels (n = 976) and > 10,000 keds were sampled over a three-year study period and the presence of Anaplasma species was determined by PCR-based assays targeting the Anaplasmataceae 16S rRNA gene. Camels were infected by a single species of Anaplasma, ‘Candidatus Anaplasma …

Temperature-Dependent Phenology Of The Parasitoid Fopius Arisanus On The Host Bactrocera Dorsalis, Samuel Nanga Nanga, S. Kekeunou, A. Fotso Kuate, K. K.M. Fiaboe, M. A. Dongmo Kenfak, H. E. Tonnang, D. Gnanvossou, C. Djiéto-Lordon, R. Hanna

All Peer-Reviewed Publications

Fopius arisanus (Sonan), an egg-pupal parasitoid of numerous fruit fly species, was recently introduced into Africa for the control of the Oriental fruit fly, Bactrocera dorsalis (Hendel). In this study, life-table data of F. arisanus were generated under laboratory conditions at six constant temperatures (15, 20, 25, 30, 28 and 35 °C; 75% RH, L12:D12 photoperiod) and under variable conditions in a screenhouse on B. dorsalis. Several non-linear functions were fitted to model species development, mortality, longevity and oviposition using the Insect Life Cycle Modeling (ILCYM) software. The established phenology models were stochastically simulated at variable temperatures to estimate the …

State: The Magazine Of Illinois State University, August 2021, Illinois State University, University Marketing And Communications

State: The Magazine of Illinois State University (1999-present)

Illinois State University alumni magazine

Retail Employees’ Ethical Value And Climate On Multidimensional Job Satisfaction: A Comparative Study With B2b Employees, Hyowon Hyun, Jungkun Park, Jihwan Yum, Sangwoo Lee

Asia Marketing Journal

In the retail industry, managing companies’ ethical environments is critical because it is associated with employee satisfaction and performance. Despite the increasing demand to understand the role of salespersons’ ethical climate and value on behavior, only a few studies have focused on this connection. Furthermore, the relative impact of ethical issues (e.g., ethical value and ethical climate) on multidimensional job satisfaction in B2B and B2C sectors remains unexplored. Thus, this study 1) explores the impact of ethical issues (e.g., ethical value and ethical climate) on multi-dimensions of job satisfaction (e.g., satisfaction with management, supervisor, co-workers, and customers) and 2) compares …

Clinicians' Experiences And Attitudes Treating Cannabis Use Disorders In Colorado: A Qualitative Inquiry Since The Legalization Of Marijuana In Colorado, Michael Walter Leiker

Doctoral Dissertations and Projects

The purpose of this phenomenological study has been to discover, describe, and understand the attitudes of Licensed Addictions Counselor’s (LACs) in treating cannabis use disorders by accessing their lived clinical experiences, and discover what regulatory, personal, environmental, social, scientific, legal, or other clinical experiences influence the decision making of LACs who treat cannabis use disorders in Colorado. This study sought to discover the attitudes, interactions, feelings, and other unique factors that form the underlying assumptions, through reciprocal determinism, that inform clinical decision-making choices independently. These dynamics have been ignored in the literature and this study seeks to pursue it with …

The Effect Of Self-Efficacy On First-Generation African American College Students, Benita Lynn Cabbler

Doctoral Dissertations and Projects

As students transition into college, some matriculate with more family, social, and academic support structures than others. Students who are the first in their families to attend college may not have the support necessary to help them succeed, influencing a need for more college resources to assist students with becoming academically successful. The purpose of this quantitative causal-comparative study was to determine if there were significant differences in perceived self-efficacy between first-generation and non-first-generation African American college students. The independent variable was African American college student status: first-generation African American college students and non-first-generation African American college students. The dependent …

Characterization Of The Structural Forces Governing The Reversibility Of The Thermal Unfolding Of The Human Acidic Fibroblast Growth Factor, Shilpi Agrawal, Vivek Govind Kumar, Ravi Kumar Gundampati, Mahmoud Moradi, Thallapuranam Krishnaswamy Suresh Kumar

Chemistry & Biochemistry Faculty Publications and Presentations

Human acidic fibroblast growth factor (hFGF1) is an all beta-sheet protein that is involved in the regulation of key cellular processes including cell proliferation and wound healing. hFGF1 is known to aggregate when subjected to thermal unfolding. In this study, we investigate the equilibrium unfolding of hFGF1 using a wide array of biophysical and biochemical techniques. Systematic analyses of the thermal and chemical denaturation data on hFGF1 variants (Q54P, K126N, R136E, K126N/R136E, Q54P/K126N, Q54P/R136E, and Q54P/K126N/R136E) indicate that nullification of charges in the heparin-binding pocket can significantly increase the stability of wtFGF1. Triple variant (Q54P/K126N/R136E) was found to be the …

Effects Of Sublethal Permethrin Exposure On Larval Culex Pipiens Response To Conspecific Alarm Cues, Margret E.H. Welch

All Student Scholarship

Organisms living in aquatic environments rely on olfactory, or chemical, information to assess predation risk in environments that are often turbid and difficult to navigate. Utilizing olfactory signals and cues enables aquatic prey to assess predation risk and grade antipredator responses to match the perceived degree of risk, which can improve survivability and fitness. Today, many aquatic habitats can become contaminated with lethal or sublethal concentrations of pollutants and pesticides which, in turn, could influence predator-prey dynamics. The purpose of this study was to examine the behavioral response of larval Culex pipiens to a simulated predation event by introducing conspecific …

Invasives In Our National Parks: How Tourists Can Help Stop The Spread Of Invasive Species, Alexandria Elivira Marci

Masters Theses

Invasive species are a major issue around the world and more specifically in our U.S. National Parks. Ranging from plants to insects to animals, invasive species are a greater threat than many may imagine. The impact that invasive species have on an ecosystem encompasses more than taking over a native species’ environment; it includes competing for food, water, and other resources, as well as having an adverse effect on our economy and threatening us with deadly diseases. Many factors lead to the cause of spread of invasive species, but all point back to human interference, from purposely spreading invasive species …

Don't Kill Mockingbird: An Educator's Guide To Teaching To Kill A Mockingbird In The 21st Century, Rachel Mayes Allen

Masters Theses

While To Kill a Mockingbird is easy to misinterpret and difficult to read at times, today’s students are capable of appreciating the novel just as much as previous generations; we as teachers simply have to give them that chance. By grounding our students in the novel’s historical context, navigating controversies gracefully and rationally, and creating meaningful learning experiences around the novel, we can help our students see To Kill a Mockingbird for what it is.

An Electrochemical Immunoassay System For Measuring Circulating Protein Biomarkers Of Pediatric Soft Tissue Sarcoma, Ivy Antwi

Electronic Theses and Dissertations

Measurement of circulating protein biomarkers associated with disease can facilitate early detection, help guide treatment strategies and improve patient outcomes beyond current standards of care. The combination of inexpensive 3D-printed flow cells and electrochemical biosensors has recently emerged as a viable platform for low-cost, reliable biomarker measurements. Here, we report an electrochemical immunoassay system based on simple graphite electrode arrays, 3D-printed flow cells, and signal-generating magnetic bead bioconjugates for simultaneous detection of three biomarker proteins (cancer antigen 125 (CA-125), midkine (MK) and osteopontin (OPN)) associated with pediatric soft tissue sarcomas (PSTS). Magnetic bead bioconjugates are functionalized with large amounts of …

Microscopic Object Classification Through Passive Motion Observations With Holographic Microscopy, Christian Lindensmith, Jay Nadeau, Manuel Bedrossian, Louis Sumrall, J. Kent Wallace, Eugene Serabyn

Physics Faculty Publications and Presentations

Digital holographic microscopy provides the ability to observe throughout a volume that is large compared to its resolution element without the need to refocus through the volume. This capability enables simultaneous observations of large numbers of small objects within such a volume. We have constructed a microscope that can observe a volume 0.4 x 0.4 x 1.0 μm with submicrometer resolution for observation of microorganisms and minerals in liquid environments in earth and on potential planetary missions. Because environmental samples are likely to contain mixtures of inorganics and microorganisms that are of comparable sizes near the resolution limit of the …

Teaching In The Age Of Covid-19—1 Year Later, Sahar D. Sattarzadeh

Education Studies Faculty publications

No abstract provided.

56 Update: Second Round Gerc Certificate Proposal Application, University Of Northern Iowa. General Education Re-Envisioning Committee.

General Education Re-envisioning Committee Documents

The packet of materials for proposals for multi-disciplinary certificates in the second call for proposals in August of 2021.

55 Update: Second Round Gerc Course Proposal Application, University Of Northern Iowa. General Education Re-Envisioning Committee.

General Education Re-envisioning Committee Documents

The packet of materials to make course proposals in the second call for applications.

Biotransformation Of Trace Organic Compounds Via Microbial Ammonia Oxidation In Biofiltration Systems For Water Reuse, Nicholas Babcock

UNLV Theses, Dissertations, Professional Papers, and Capstones

The use of ozone-biofiltration (BAF) for water reuse has recently been viewed as an attractive option due its low cost and ability to achieve high quality effluent. However, one challenge that is particularly problematic for ozone-biofiltration is the occurrence of trace organic compounds (TOrCs), such as pharmaceuticals and personal care products, in domestic wastewater, primarily due to their uncertain public health impacts. These TOrCs might be degraded by three ammonia oxidizing microorganisms (AOMs), including ammonia oxidizing bacteria (AOBs), ammonia oxidizing archaea (AOAs), and Comammox that have been found in biofiltration systems. Cometabolism, the fortuitous biodegradation of compounds by enzymes used …

Analysis Of Microscopic Objects Using Computer Vision Methods, Yuan Dao

UNLV Theses, Dissertations, Professional Papers, and Capstones

As an essential and powerful tool to observe living organisms, three-dimensional fluorescence microscopy is widely used in biological research and diagnosis. The 4D fluorescence microscopy data can be obtained using time-lapsed videos of 3D images. To analyze and extract useful information from the increasingly large and complex biological image dataset, efficient and effective computational tools are in need but still lagging behind. In analyzing biological data, two major challenges are faced. First, time-lapsed fluorescence microscopic images typically have a low SNR. Second, biological objects often change their morphology and internal structure frequently. As such, conventional image processing methods may not …