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Gc-Ms Profiling, Antioxidant, Antimicrobial Activities, Dna Cleavage Effect Ofsymphytum Aintabicum Hub.-Mor. & Wickens (Boraginaceae) And Its Anticancer Activityon Mcf-7 Cell Line, Alevcan Kaplan

Turkish Journal of Botany

Symphytum species, generally known as comfrey, have been used for ancient times in folk medicine for wounds, bone breakages, rheumatism, liver problems, and innumerable potentialities. However, many of the species belonging to the genus Symphytum have not been analyzed with scientific methods and principles yet. Therefore, this work is a guide for determining and researching the main gaps in the literature. In this study, MeOH and petroleum ether (PE) extracts of Symphytum aintabicum Hub.-Mor. & Wickens were analyzed for their biological activities and GC-MS analysis, antioxidant, antimicrobial activities, DNA cleavage effect, and anticancer activity on the MCF-7 human breast cell …

Anticancer, And Antioxidant Activities Of Royal Jelly On Ht-29 Colon Cancer Cells Andmelissopalynological Analysis, Adnan Ayna, Abdullah Tunç, Seda Nur Özbolat, Aydin Şükrü Bengü, Gürkan Aykutoğlu, Deni̇z Canli, Ridvan Polat, Mehmet Çi̇ftci̇, Ekrem Darendeli̇oğlu

Turkish Journal of Botany

Royal jelly (RJ) is reflecting the flora around the apiaries as a result of the foraging activity of honeybees and therefore, pollen analysis could be used to verify its botanical/geographical origin. Colon cancer treatment by means of chemotherapeutics agents reflects a substantial problem for the organism due to high toxicity to other viable cells of the body. To explore a chemopreventive approach to enhancing colon cancer treatment efficacy, the antioxidant and antiproliferative effects of RJ in HT-29 colon cancer cells were assessed. Cell proliferation was performed by WST-1 assay, index of apoptosis was calculated by TUNEL Assay, antioxidant activities were …

Southeast Michigan Wastewater Treatment Plants As Potential Sources Of Microplastic Pollution In The Rouge River And Huron River, Jennifer Troost

Master's Theses and Doctoral Dissertations

Plastic pollution is a global issue affecting the health and stability of freshwater and marine environments. Microplastics can be introduced into waterways from a variety of sources, such as agricultural runoff, anthropogenic litter, and wastewater treatment plants (WWTPs). To determine whether WWTPs are a source of microplastics to the Lower Rouge and Huron Rivers, we measured microplastic load upstream and downstream of two Southeast Michigan wastewater treatment plants: the Ann Arbor Wastewater Treatment Plant and Ypsilanti Community Utilities Authority (YCUA). Results from this study indicated that YCUA, which discharges into a small stream with limited watershed inputs, is a significant …

Association Between Anthropometric Factors And Balance Among Elderly Fallers And Non-Fallers: A Cross-Sectional Study, Pothiraj Pitchai, Reshma Gurav, Srishti Kuldeep Chauhan

Internet Journal of Allied Health Sciences and Practice

Purpose: Falls are an emerging public health problem causing a cascade of medical, functional, and socio-economic consequences. Apart from other widely explored risk factors affecting balance, anthropometric factors are also known to have an impact on balance. However, this relationship hasn’t been studied extensively in older adults. This study aimed to evaluate the relationship between the anthropometric factors such as Body Mass Index (BMI), Body Fat Mass (BFM), Waist-Hip Ratio (WHR), Lower Limb Length (LLL), Foot Length (FL) and balance in the elderly among fallers and non-fallers. Method: This cross-sectional study was performed on 100 fallers and 100 non-fallers, aged …

Covid-19 Crisis Management Strategies And Challenges Of Educational Leaders In America, Corinne Brion, Bilgen Kiral

Educational Leadership Faculty Publications

This research was conducted to understand how 30 American school leaders managed during the COVID-19 pandemic. This qualitative study used a case study approach. The researchers utilized a convenience and snowball sampling to conduct Zoom interviews in May 2020. The research findings revealed that leaders encountered numerous difficulties related to having to lead during two crises (a global pandemic and social-racial issues). Findings also indicated that leaders altered their style and used many strategies to lead in times of crises: They emphasized communication, became stress managers and cheer leaders, focused on developing a sense of belonging among teachers and students …

New Evidence For P-Gp-Mediated Export Of Amyloid-Β Peptides In Molecular, Blood-Brain Barrier And Neuronal Models, Amanda B. Chai, Anika M. S. Hartz, Xuexin Gao, Alryel Yang, Richard Callaghan, Ingrid C. Gelissen

Sanders-Brown Center on Aging Faculty Publications

Defective clearance mechanisms lead to the accumulation of amyloid-beta (Aβ) peptides in the Alzheimer’s brain. Though predominantly generated in neurons, little is known about how these hydrophobic, aggregation-prone, and tightly membrane-associated peptides exit into the extracellular space where they deposit and propagate neurotoxicity. The ability for P-glycoprotein (P-gp), an ATP-binding cassette (ABC) transporter, to export Aβ across the blood-brain barrier (BBB) has previously been reported. However, controversies surrounding the P-gp–Aβ interaction persist. Here, molecular data affirm that both Aβ₄₀ and Aβ₄₂ peptide isoforms directly interact with and are substrates of P-gp. This was reinforced ex vivo by the …

Combating The High Prevalence Of Obesity Among Egyptian Households: A Pilot Study: Port-Said Households/ مكافحة السمنة في المجتمع المصري: دراسة تجريبية في بورسعيد, Asmaa Sedky, Marwa Gaber, Noha Magdy, Shaimaa El Safoury

Papers, Posters, and Presentations

Obesity is a major public health issue in Egypt and its repercussions are not only limited to the health dimension but also extend to affecting the productive capacity of the citizens. This adversely affects the overall fundamentals of the Egyptian economy. Moreover, there is a current political interest in promoting the health and well-being of the citizens which is reflected in the recent 100 Million Seha massive campaign that measured the weight and height of millions of Egyptians.

By applying the decision-making rule which has to do adhere to the equity, administrative, and political criteria, we recommend adjusting the Egyptian …

Does Medical Racism Influence Medical Mistrust In The Black Community?, Danielle Forrest

Honors Undergraduate Theses

Mistrust in the medical field can be generated through experiences of racism and discrimination during interactions with members of the medical community. Black and African American individuals find themselves facing increased rates of morbidity including heart disease, and diabetes, and increased rates of mortality as compared to White individuals yet are treated less frequently and to a lesser extent. This thesis examines the mistrust black people have towards the medical field, as well as differences within the black community in terms of experiences with medical racism. In order to collect this information, I created a survey that enquires about race …

Using A Lubricin Reporter Cell To Test Current Vs. Optimized Media Compositions, Sean M. Kennedy

Honors Undergraduate Theses

Osteoarthritis is a joint disease characterized by the breakdown of articular cartilage. The field of tissue engineering is interested in developing methods to produce biological alternatives to current orthopedic procedures. Lubricin is a molecule which is important in the proper lubrication of articular cartilage. It is a challenge in the field of tissue engineering to produce cartilage with sufficient lubricin expression. Developing a reporter cell for lubricin allowed for a more efficient investigation of the conditions wh­­­ich may influence its expression. By comparing "optimized" and traditional media solutions, it was determined that the use of a previously reported type II …

Pineal Gland Abnormalities And The Relationship Of Melatonin To The Development And Symptom Severity Of Schizophrenia: An Integrative Review Of The Literature, Kathryn Margretta

Honors Undergraduate Theses

The purpose of this thesis is to critique the literature focusing on the role of pineal gland volume and function and the development of schizophrenia by asking the question, "What is the relationship between pineal gland physiologic function and development and symptom severity of schizophrenia? It is crucial that health care providers continue advocate for better understanding of schizophrenia in order to develop a more appropriate treatment and relive the suffering of those with schizophrenia. A review of published literature focusing on the pineal glands association with schizophrenia was performed using several databases including: ScienceDirect, PubMED, Google Scholar, Cumulated Index …

A Mixed Methods Study On Food Insecurity Screening And Patient-Centered Care: Perspectives Of Patients And Healthcare Providers On Practices And Barriers To Effective Screening In Outpatient Medical Settings, Christina Bernhardt

Electronic Theses and Dissertations, 2020-2023

The purpose of this study was to better understand the relationship between elements of patient-centered care and patient/provider comfort with conversing about food insecurity and related social determinants of health. A mixed methods study was conducted. Patients and healthcare providers were surveyed on their experiences with patient-centered care and comfort discussing food insecurity and related social concerns. Telephone interviews were conducted to gain a richer understanding of the concepts under investigation. In the survey and telephone interviews, both samples were also asked about changes in communication during COVID-19 times. Quantitative findings show that patient involvement in care and cultural sensitivity …

Exploring The Academic Workload Of Second Year Medical Students, Jason Pollock

Electronic Theses and Dissertations, 2020-2023

Excessive academic workload has been cited as a leading cause of medical student stress, depression, and drop out. A study was conducted at a Southeastern Medical School to identify a relationship between institutionally prescribed workload (objective workload) and the students' perceptions (subjective workload). The existing school workload policy and the Rice University Center for Teaching Excellence workload estimator were utilized to calculate time to complete two types of academic artifacts: (1) assigned (required) course materials and (2) recommended (optional) course materials, which we compared at the Module level to identify difference in objective workload. The students' perceptions of workload were …

Comparing Teacher Responses To The Covid-19 Pandemic In Venezuela And The United States, Maria Spinetti Rincon

Electronic Theses and Dissertations, 2020-2023

The COVID-19 Pandemic has impacted the entire world. Teachers have been challenged throughout this time to adapt their teaching practices amidst a constantly changing environment. The purpose of this study was to answer the research questions: (1) how did teachers' responses to the COVID-19 pandemic vary between the United States and Venezuela? And (2) what do teachers perceive they need to better support children in the aftermath of the COVID-19 pandemic? This research used an interpretive, case study approach through kindergarten teacher interviews and curricula analysis. Teachers were included in the study if they had taught for more than five …

Downregulation Of Mir-34a Via Calorie Restriction Regulates Lipid Metabolism In The Liver Of Long-Living Ames Dwarf Mice, Sarah Ashiqueali

Electronic Theses and Dissertations, 2020-2023

Ames dwarf mice (df/df) display delayed aging relative to their normal siblings, living approximately 40-60% longer. As such, investigating the mechanisms that enable these organisms to have superior life expectancies may prove useful in developing therapies to slow aging and deter age-related disease. Nonalcoholic fatty liver disease (NAFLD) is a condition that is characterized by the accumulation of excess adipose tissue in the liver. Interestingly, its prevalence tends to increase with age with an incidence rate of greater than 40% in individuals over the age of 60. Previous studies highlight the potential of calorie restriction (CR) in promoting longevity, but …

Influence Of Body Composition, Velocity Profiles, And Sex-Related Differences On Army Combat Fitness Test Performance, David Boffey

Electronic Theses and Dissertations, 2020-2023

The Army Combat Fitness Test (ACFT) will become the United States Army's mandatory physical fitness test in March of 2022. The purpose of this study was to determine the relationship between ACFT performance and both body composition and velocity profiles, and to determine sex differences for these variables. Data was collected in November 2020 (Fall) and March 2021 (Spring) from male (n = 55) and female (n = 17) Army Reserve Officers' Training Corps (ROTC) cadets. Body composition was assessed with a bioelectrical impedance spectroscopy (BIS) device, and cadets completed a squat jump (SJ) force-velocity profile (FVP) and a hex …

An Investigation Of Student Mental Health Supports In Florida Public School Districts, Rebecca Carter

Electronic Theses and Dissertations, 2020-2023

The purpose of this study was to determine the mental health services being provided to students in the state of Florida, specifically the identification of mental health concerns among students, prevention strategies, and interventions utilized. This study consisted of a document analysis of the Mental Health Assistance Allocation Plans submitted to, and posted by, the Florida Department of Education, for the purpose of developing a grounded theory to standardize the recommended practices in serving the mental health needs of students. Standardized recommended practices that emerged from the analysis included (a)universal screening to identify students demonstrating or developing mental health concerns, …

Paleoethnobotanical Analysis Of Maya Ceramic Residues From Holtun, Guatemala, Kimberly Batres

Electronic Theses and Dissertations, 2020-2023

To the Maya, plant-based foods were not just important for sustenance but also had ritual meaning that was especially emphasized when placed in graves and caches. Food offered during ritual performances created a reciprocal relationship between living individuals, their ancestors, and the gods. The following thesis examines seven ceramic sherds associated with burial and cache offerings of individuals from the lowland Maya site of Holtun, Guatemala, that were found to have contained food offerings. Starch analysis, a method used to determine plant taxa on a microscopic level was performed on the ceramic vessels along with various experimental molecular spectroscopic procedures. …

Influence Of Geography On The Healthy Gut Microbiome And The Role Of The Gut Microbiome In Ibd Symptom And Disease Progression, Sayf Al-Deen Hassouneh

Electronic Theses and Dissertations, 2020-2023

The human gut microbiome is believed to play an integral role in host health and disease. In a microbial community, associations between constituent members play an important role in determining the overall structure and function of the community. To understand the nature of bacterial associations at the species level in healthy human gut microbiomes, we analyzed previously published collections of whole-genome shotgun sequence data, from fecal samples obtained from four different healthy human populations. Using a Random Forest Classifier, we identified bacterial species that were prevalent in these populations and whose relative abundances could be used to accurately distinguish between …

Three Essays In Applied Microeconomics: Spillover Effects Of Anti Discrimination And Anti Violence Policies, Gokhan Kumpas

Doctoral Dissertations

In this research, I examine the intended and unintended consequences of three highly debated policies at the state and federal level: enactment of Title IX, state anti-bullying laws, and warrantless arrest laws aimed at curbing domestic violence. My first essay examines the causal relationship between athletic participation and means-tested program participation. I use the variation in the implementation of Title IX and find that a 30 percentage-point increase in female athletic participation induced by Title IX increased program participation among 25 to 40-year-old females by 2.8 percentage-points. This effect persists across SNAP, TANF, and Medicaid recipiency. Event study analysis and …

From An Insect To The Classroom: Evolutionary Insights Into The Ecological And Behavioral Impacts Of Experience, Brooke Kathleen Woelber-Kastner

Doctoral Dissertations

Organisms exhibit suites of life history traits which enable them to respond to environmental stimuli and increase fitness. However, the relationship between organism traits and the environment is not unidirectional, rather they are in a state of constant interaction. To further our understanding of the interactions between the environment and organism phenotypes, this dissertation focuses on a group of insect scavengers, the burying beetles (Coleoptera: Silphidae: Nicrophorus) which utilize carrion to initiate reproduction and feed developing young. Here I apply ecological and molecular methodologies to demonstrate that behaviors provide an important ecological service by sequestering carrion in forest ecosystems. I …

Utilization Of Exotic Germplasm In A Cucurbita Breeding Program, Andrew Burkeland Ogden

Doctoral Dissertations

Crops in the Cucurbitaceae plant family are an important part of agricultural systems worldwide. This family includes economically important crops such as watermelon, cucumber, pumpkins, melons, and squash. These crops are plagued by a wide variety of both insect and plant pathogen pests. Breeding for genetic resistance to these pests represents a key component of many cucurbit breeding programs in both public and private sectors. Sources for disease and pest resistance often include wild species and landraces found across the world. Often, such species show poor adaptability to temperate climates. This limits plant breeders’ abilities to utilize exotic germplasm and …

Cranial Capacity Measurement For Modern Chinese Adults Based On 3d Reconstruction, Yufeng Qian, Songou Zhang, Qihuan Tan, Jianyu Xia, Guoliang Jin

Neurosciences

Objectives: To determine the average modern adult cranial capacity in China, and assess the gender differences and trends in order to establish normal reference values and provide theoretical basis for individualized treatment in clinical practice. Methods: We conducted a cross-sectional study between January 2019 to June 2020. Thin-slice (0.9 mm) CT scans of 309 males and 238 females from China were obtained, and classified into the 18-32, 33-47, 48-62, 63-77 and 78-92 years age groups. Three-dimensional reconstruction was performed using mimics software to obtain the cranial capacity for statistical analysis. Results: The average cranial capacity of men was 1497.12±120.70 cm3 …

Pregnant And Detained: Constitutional Rights And Remedies For Pregnant Detainees, Natalie Avery Barnaby

Journal of Criminal Law and Criminology

Over the last thirty years, the United States has increasingly expanded what is already the largest immigration detention system in the world. On a daily basis, the U.S. government holds more than 50,000 people in detention as they wait for their immigration hearings or their removal back to their home country. During the past two decades, presidential administrations have enacted regulations to deter immigrants from entering the United States and narrow their ability to stay in the country, leading to an overall increase in detentions.

There is wide documentation of poor detention conditions, inadequate medical care, and overcrowding in immigration …

The Bandana Project: Program Evaluation Plan, Stephanie Nickole Vazquez

Public Health Theses

Mental health concerns are highly prevalent within the college student population. While there are various campus mental health resources available for students to seek help, many choose not to due to their lack of knowledge around navigating resources and the pervasive stigma around mental illnesses. A solution to this problem is The Bandana Project (BP), an innovative mental health awareness and suicide prevention program aimed at changing social norms on college campuses. The initiative’s goals are to combat the stigma around mental illness and seeking care all while boosting the social support between students and their campus peers.

After five …

Social Services And Mutual Aid In Times Of Covid-19 And Beyond: A Brief Critique, Dana Neacsu

Law Faculty Publications

May 19, 2021, marked a crucial point in the United States’ fight against the COVID-19 pandemic: sixty percent of U.S. adults had been vaccinated. Since then, Americans have witnessed the beginning of the end of the COVID-19 pandemic, but its long-term effects are here to stay. Ironically, some are unexpectedly welcome. Among the lasting positive changes is an augmented sense of individual involvement in community well-being. This multifaceted phenomenon has given rise to #BLM allyship and heightened interest in mutual aid networks. In the legal realm, it has manifested with law students, their educators, lawyers, and the American Bar Association …

Clinical And Molecular Findings In 37 Turkish Patients With Isolated Methylmalonic Acidemia, Berna Şeker Yilmaz, Deni̇z Kör, Fatma Derya Bulut, Sebi̇le Kilavuz, Serdar Ceylaner, Hali̇se Nesli̇han Önenli̇ Mungan

Turkish Journal of Medical Sciences

Background/aim: Isolated methylmalonic acidemia (MMA) is caused by complete or partial deficiency of the enzyme methylmalonylCoA mutase (mut0 or mut- enzymatic subtype), a defect of its cofactor adenosyl-cobalamin (cblA, cblB, or cblD-MMA), or deficiency of the enzyme methylmalonyl-CoA epimerase. While onset of the disease ranges from the neonatal period to adulthood, most cases present with lethargy, vomiting and ketoacidosis in the early infancy. Major secondary complications are; growth failure, developmental delay, interstitial nephritis with progressive renal failure, basal ganglia injury and cardiomyopathy. We aimed to demonstrate clinical and molecular findings based on long-term follow up in our patient cohort. Materials …

Does Previous Open Or Percutaneous Renal Stone Surgery Affect Retrograde Intrarenalsurgery Outcomes?, Özer Güzel, İbrahi̇m Can Aykanat, Yilmaz Aslan, Ahmet Asfuroğlu, Meli̇h Balci, Altuğ Tuncel

Turkish Journal of Medical Sciences

Background/aim: Open or percutaneous renal stone surgery can have an adverse effect on the collecting system of the kidney. We evaluated retrograde intrarenal surgery outcomes in patients with 󖼮 mm renal stones who had open or percutaneous renal stone surgery history. Materials and methods: A total of 707 patients who underwent retrograde intrarenal surgery treatment were included in this study. Fifty-six patients had open or percutaneous renal stone surgery history (Group 1) and the remaining did not (Group 2, n = 651). The groups were compared in terms of age, stone size, stone-free rates, and complications. Results: The mean age …

Genistein Suppresses The Inflammation And Gsk-3 Pathway In An Animal Model Ofspontaneous Ovarian Cancer, Füsun Erten, Engi̇n Yeni̇ce, Cemal Orhan, Beşi̇r Er, Pinar Demi̇rel Öner, Patrick Brice Defo Deeh, Kazi̇m Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: Numerous studies show that cancer risk is reduced by consumption of soy-based foods containing genistein, but its effects on the glycogen synthase kinase-3 pathway (GSK-3) in ovarian cancer is unknown. Therefore, we tested the properties of genistein on inflammatory biomarkers and GSK-3 signaling pathways in the ovaries of old laying hens with ovarian cancer. Materials and methods: A total of 300 laying hens were distributed into three groups as follows: group 1, animals fed a standard diet (comprising 22.39 mg of genistein/kg of diet); groups 2 and 3, animals fed a standard diet reconstituted with supplementation of 400 mg …

Effect Of Betulinic Acid Administration On Tlr-9/Nf-Κb /Il-18 Levels In Experimentalliver Injury, Eda Dokumacioğlu, Hati̇ce İskender, Kübra Asena Teri̇m Kapaki̇n, Güler Yeni̇ce, Behzat Mokthare, İsmai̇l Bolat, Armağan Hayirli

Turkish Journal of Medical Sciences

Background/aim: Acetaminophen (APAP), used in the composition of thousands of preparations, is the most commonly used analgesic and antipyretic drug. The present study aimed to investigate the potential protective effects of the betulinic acid (BA) treatment through an APAP-induced hepatotoxicity rat model, using inflammatory, biochemical, and histopathological parameters. Materials and methods: The study consisted of four groups: control group, APAP group, BA group, and APAP+BA group. Experimental studies continued for fifteen days. Serum samples were analysed for glucose, total cholesterol (TChol), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), aspartate amino transferase (AST), malondialdehyde (MDA), toll-like receptor-9 (TLR-9), …

Influenza And Pneumococcus Vaccination Rates In Pediatric Dialysis Patients Ineurope: Recommendations Vs Realitya European Pediatric Dialysis Working Group And European Society For Pediatricnephrology Dialysis Working Group Study, Yeşi̇m Özdemi̇r Ati̇kel, Sevcan Azi̇me Bakkaloğlu Ezgü, Fabio Paglialonga, Constantinos J. Stefanidis, Varvara Askiti, Enrico Vidal, Gema Ariceta, Engi̇n Melek, Enrico Verrina, Nikoleta Printza, Karel Vondrak, Aleksandra Zurowska, Ilona Zagozdzon, Mesi̇ha Eki̇m, Eli̇f Nursel Özmert

Turkish Journal of Medical Sciences

Background/aim: Children on dialysis are under increased risk of influenza and invasive pneumococcal disease. Although vaccination against these microorganisms are recommended in dialysis patients and despite the fact that these vaccines can reduce disease burden and rates of hospitalization due to infection, vaccination rates are below expected and desired. We aimed to evaluate influenza and pneumococcal vaccination and infection rates in European pediatric dialysis centers. Materials and methods: In 16 centers from 11 countries, 357 pediatric dialysis patients were evaluated retrospectively during 1 year of observation period between 01.01.2014 and 01.01.2015. Results: In all centers, vaccination policy included immunization of …