Digital Commons Network^™

Female Mice May Have Exacerbated Catabolic Signalling Response Compared To Male Mice During Development And Progression Of Disuse Atrophy, Megan E. Rosa-Caldwell, Seongkyun Lim, Wesley A. Haynie, Jacob L. Brown, John William Deaver, Francielly Morena Da Silva, Lisa T. Jansen, David E. Lee, Michael P. Wiggs, Tyrone A. Washington, Nicholas P. Greene

Health & Kinesiology Faculty Publications and Presentations

Background: Muscle atrophy is a common pathology associated with disuse, such as prolonged bed rest or spaceflight, and is associated with detrimental health outcomes. There is emerging evidence that disuse atrophy may differentially affect males and females. Cellular mechanisms contributing to the development and progression of disuse remain elusive, particularly protein turnover cascades. The purpose of this study was to investigate the initial development and progression of disuse muscle atrophy in male and female mice using the well-established model of hindlimb unloading (HU). Methods: One hundred C57BL/6J mice (50 male and 50 female) were hindlimb suspended for 0 (control), 24, …

Narrowing The Achievement Gap Through Culturally Responsive Teaching, Natasha V. Forde

Graduate Student Dissertations, Theses, Capstones, and Portfolios

The achievement gap currently persists between Black, White, and Hispanic students. The purpose of this action research study was to determine how a series of five professional development workshops on Culturally Responsive Teaching could ultimately narrow or close the achievement gap between Black, White, and Hispanic students through implementing Culturally Responsive Teaching strategies in classrooms to meet the needs of the diverse student population. In addition, this study also examined the teachers’ perceptions of the Culturally Responsive Teaching professional development workshops to positively impact student achievement with Black and Hispanic students.

The objectives of this study included:

• The identification of …

Early Effects Of The Covid-19 Lockdown On Children In Rural Bangladesh, Momoe Makino, Abu S. Shonchoy, Zaki Wahhaj

Poverty, Gender, and Youth

Using data collected through a telephone-based survey in rural Bangladesh during the height of the pandemic, we present evidence on the effects of COVID-19-led lockdown and school closures on children, focusing on three child-related outcomes: time use of children during the school closure, plans regarding children's schooling continuation, and the incidence of child marriages. Our analysis reveals heterogeneity in the effects of lockdown and school closure in terms of the child's gender and the type of shocks. We find a decrease in children's study time and an increase in time spent on household chores during the school closure, and these …

Costing Social And Behavior Change Programming: The Role Of The Denominator, Breakthrough Research

Reproductive Health

This is the first in a series of brief reports intended to complement Breakthrough RESEARCH's Costing Guidelines and support a social and behavior change community of practice by discussing important issues and practices for social and behavior change costing. Breakthrough RESEARCH is gathering, analyzing, and sharing evidence on the costs and impact of social and behavior change interventions to support social and behavior change investments, which are crucial for improving health and advancing development. A review of costing literature identified 147 studies on social and behavior change costs, methodological shortcomings, and knowledge gaps that can be addressed in new costing …

Caffeine Modulates Pharmacokinetic And Pharmacodynamic Profiles Of Pioglitazone In Diabetic Rats: Impact On Therapeutics, Ali M. Alshabi, Saad A. Alkahtani, Ibrahim A. Shaikh, Mohammed S. Habeeb

Saudi Medical Journal

Objectives: To determine the influence of caffeine on pharmacokinetics and pharmacodynamics of pioglitazone (PIO) in diabetic rats. Methods: This was a preclinical study conducted in the College of Pharmacy, Najran University, Saudi Arabia, using 5 groups of Wistar rats: normal rats, untreated diabetic rats, diabetic rats + caffeine (20 mg/kg), diabetic rats + PIO (10 mg/kg), and diabetic rats + PIO (10 mg/kg) + caffeine (20 mg/kg). The drugs were administered for 14 days, and fasting plasma glucose concentrations were determined on the first day, and thereafter at weekly intervals. On day 14, rat sacrifice was followed with assay of …

Identifying Health Topics For Elementary-Aged Children In Delaware, Kayla Morrell, Denise Hughes

Phase 1

Introduction: Health literacy involves understanding health-related information to make educated decisions regarding an individual’s needs. Low health literacy is associated with poorer health outcomes, which can be minimized by early introduction to accurate health information. Currently, elementary schools in Delaware have no health curriculum, leaving students at risk for low health literacy.

Methods: Interviews were conducted with Delaware elementary school teachers to identify a series of topics that would allow students to learn health information via incorporation into existing curriculum. Teachers were divided into focus groups by school and grade level. The resulting discussions were qualitatively analyzed by two independent …

Nutritional Intervention In Concussion Treatment And Analysis Using Mri And Eeg, Jideofor Okafor, Namdi Nwasike, Andrew Newberg, Md

Phase 1

Traumatic brain injuries (TBI) occur in over one million Americans annually, leading to thousands of deaths, hospitalizations, and individuals with long term disability. The most common causes of TBI which result in hospitalization primarily affect middle-aged to older adults and contribute to the annual economic burden of billions of dollars. The goal of this study is to determine if baseline EEG scans predict responsiveness to supplemental treatment in TBI patients experiencing chronic symptoms, which could improve their care.

Subjects recruited from the greater Philadelphia area were randomly separated into 3 groups—Control, N-acetylcysteine (NAC), or Nutrition—and either received standard treatment for …

Results Of The 2020 Immunization Status Survey Of 24-Month Old Children In Tennessee, Tennessee. Department Of Health.

Immunization Rates

No abstract provided.

Tennessee Diabetes Action Report, February 2021, Tennessee. Department Of Health.

Diabetes Action Report

No abstract provided.

Supplements With Medications, Chase Burlingame Bsn, Rn, Samantha Peterson Bsn, Rn, Dante Vagnoni Bsn, Rn

Vizient/ AACN Nurse Residency Program™ EBP Projects

No abstract provided.

Delivering Maternal And Neonatal Health Interventions In Conflict Settings: A Systematic Review, Mariella Munyuzangabo, Michelle F. Gaffey, Dina S. Khalifa, Daina Als, Anushka Ataullahjan, Mahdis Kamali, Reena P. Jain, Sarah Meteke, Amruta Radhakrishnan, Shailja Shah, Fahad J. Siddiqui, Zulfiqar Ahmed Bhutta

Centre of Excellence in Women and Child Health

Background: While much progress was made throughout the Millennium Development Goals era in reducing maternal and neonatal mortality, both remain unacceptably high, especially in areas affected by humanitarian crises. While valuable guidance on interventions to improve maternal and neonatal health in both non-crisis and crisis settings exists, guidance on how best to deliver these interventions in crisis settings, and especially in conflict settings, is still limited. This systematic review aimed to synthesise the available literature on the delivery on maternal and neonatal health interventions in conflict settings.
Methods: We searched MEDLINE, Embase, CINAHL and PsycINFO databases using terms related to …

Rethinking The Reasonable Response: Safeguarding The Promise Of Kingsley For Conditions Of Confinement, Hanna Rutkowski

Michigan Law Review

Nearly five million individuals are admitted to America’s jails each year, and at any given time, two-thirds of those held in jail have not been convicted of a crime. Under current Supreme Court doctrine, these pretrial detainees are functionally protected by the same standard as convicted prisoners, despite the fact that they are formally protected by different constitutional amendments. A 2015 decision, Kingsley v. Hendrickson, declared that a different standard would apply to pretrial detainees and convicted prisoners in the context of use of force: consistent with the Constitution’s mandate that they not be punished at all, pretrial detainees …

Corn Residue Baling And Grazing Impacts On Corn Yield Under Irrigated Conservation Tillage Systems, Sabrina J. Ruis, Charles Burr, Humberto Blanco-Canqui, Brian Olson, Mark Reiman, Daran Rudnick, Johnna Baller, Kathryn J. Hanford

Department of Agronomy and Horticulture: Faculty Publications

Crop residue grazing or baling is common in the western Corn Belt. However, its impacts on subsequent crop yields under different irrigation levels and tillage systems are unclear. We investigated the impacts of corn (Zea mays L.) residue baling and cattle grazing on soil compaction, water content, and corn yield under full and limited irrigated no-till in Nebraska during three years. In Years 2 and 3, an additional tillage treatment (strip till) was implemented to evaluate its effects on grain yield under the above treatments. Residue removal effects on compaction and water content did not vary with irrigation level. …

California V. Texas: The Role Of Congressional Procedure In Severability Doctrine, Mary Leto Pareja

Faculty Scholarship

The United States Supreme Court is once again considering a case that challenges the constitutionality of the Affordable Care Act (“ACA”). In this round of litigation, plaintiffs argue that because Congress lowered the individual mandate tax penalty to zero in the 2017 Tax Act that makes the individual mandate itself unconstitutional and that, furthermore, the individual mandate cannot be severed from the rest of the ACA. The District Court agreed with the plaintiffs and struck down the entire ACA, and the Supreme Court granted cert to hear this momentous question. A decision is expected by summer of 2021.

The ACA …

Consumer Likings Of Different Miracle Fruit Products On Different Sour Foods, Sung-Eun Choi, Jeff Garza

Publications and Research

Miracle fruit has a high potential as a healthy sweetening enhancer, due to its powerful antioxidant capacity and its unique ability to transform sour taste into sweet taste. The aim of this study was to analyze the effect of different miracle fruit products on the likings of different sour foods.In total, 200 healthy adults (women 55%, 18–65 years old) evaluated five sour foods (apple, goat cheese, lemonade, yogurt, pickle) before and after miracle fruit application. Four commercial miracle fruit products (pills-Y; G; M, powder-P) were randomly assigned to each panelist. The pre- and post-test likings for overall, flavor, texture, and …

Report From The Conference, ‘Identifying Obstacles To Applying Big Data In Agriculture’, Emma L. White, J. Alex Thomasson, Brent Auvermann, Newell R. Kitchen, Leland Sandy Pierson, Dana Porter, Craig Baillie, Hendrik Hamann, Gerrit Hoogenboom, Todd Janzen, Rajiv Khosla, James Lowenberg-Deboer, Matt Mcintosh, Seth Murray, Dave Osborn, Ashoo Shetty, Craig Stevenson, Joe Tevis, Fletcher Werner

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Data-centric technology has not undergone widespread adoption in production agriculture but could address global needs for food security and farm profitability. Participants in the U.S. Department of Agriculture (USDA) National Institute for Food and Agriculture (NIFA) funded conference, “Identifying Obstacles to Applying Big Data in Agriculture,” held in Houston, TX, in August 2018, defined detailed scenarios in which on-farm decisions could benefit from the application of Big Data. The participants came from multiple academic fields, agricultural industries and government organizations and, in addition to defining the scenarios, they identified obstacles to implementing Big Data in these scenarios as well as …

Student Well-Being In The Time Of Covid: Survey Of Online Students’ Coping, Ellen Catherine Coble

Theses and Dissertations

The emergence of the COVID-19 pandemic has presented the global population with a considerable stressor resulting in significant loss of life, impaired health, disrupted social practices, and economic atrophy. While many have been impacted and are currently being studied, a population less frequently considered in the literature is that of online college students. Previous research has indicated the influence of several factors on college students’ well-being when coping with stress under typical circumstances such as coping strategies (e.g., problem-focused, emotion-focused, and avoidant/dysfunctional), experiential avoidance, and social support. Studies performed in the wake of large-scale crises highlight proximity to the crisis …

Virtual Home Assistant Use And Perceptions Of Usefulness By Older Adults And Support Person Dyads, Cynthia F. Corbett Phd, Rn, Faan, Elizabeth M. Combs, Pamela J. Wright Phd, Ms, Med, Rn, Cen, Otis L. Owens, Isabel Stringfellow, Thien Nguyen, Catherine R. Van Son

Publications

Aim: Describe virtual home assistant use and usefulness from the perspective of older adults and their support persons. Methods: This was a mixed-methods study with older adults and their support persons (n = 10 dyads). Virtual home assistant (VHA) equipment was installed in participants’ homes, and its use was documented for 60 days. Participants received protocol-guided telephone calls to address their VHA questions or problems. The type and frequency of VHA use were summarized with descriptive statistics. End-of-study interviews about VHA use were conducted with dyad participants. Qualitative content analyses were used to describe the interview findings about the dyad’s …

Association Of Baseline Characteristics With Insulin Sensitivity And Β-Cell Function In The Glycemia Reduction Approaches In Diabetes: A Comparative Effectiveness (Grade) Study Cohort, Neda Rasouli, Naji Younes, Kristina M Utzschneider, Silvio E Inzucchi, Ashok Balasubramanyam, Andrea L Cherrington, Faramarz Ismail-Beigi, Robert M Cohen, Darin E Olson, Ralph A Defronzo, William H Herman, John M Lachin, Steven E Kahn

Faculty, Staff and Students Publications

OBJECTIVE: We investigated sex and racial differences in insulin sensitivity, β-cell function, and glycated hemoglobin (HbA

RESEARCH DESIGN AND METHODS: This is a cross-sectional analysis of baseline data from 3,108 GRADE (Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study) participants. All had type 2 diabetes diagnosedβ-cell function were evaluated using the HOMA of insulin sensitivity and estimates from oral glucose tolerance tests, including the Matsuda Index, insulinogenic index, C-peptide index, and oral disposition index (DI).

RESULTS: The cohort was 56.6 ± 10 years of age (mean ± SD), 63.8% male, with BMI 34.2 ± 6.7 kg/m

CONCLUSIONS: In the …

Veg Out! Use Of An Infomercial-Style Format In A Produce Awareness Program, Morgan Bahl, Sarah L. Francis, Mary Krisco

Journal of Extension

Veg Out! is an infomercial-style produce awareness session. We use image-focused rather than content-focused slides to highlight the health benefits associated with produce consumption. This image-focused approach is helping participants become more familiar with produce serving sizes and increasing the likelihood of their consuming more produce. Our findings suggest that an image-focused education session is an effective strategy for promoting familiarity with the topic being presented and increasing the likelihood of behavior change.

Preparing Extension Educators For Community-Based Research And Grant Partnerships, Cheryl Eschbach, Holly Tiret, Erin Carter, Cathy Newkirk

Journal of Extension

Two trainings to prepare Extension educators for research and grant partnerships were designed, implemented, and evaluated. These trainings further national goals to address health disparities, gain partnerships in the health care sector, and support health extension. The workshop Are You Research Ready? prepares Extension educators to participate in community-based human health research. Evaluations indicated that attendees gained a self-assessment of research readiness and felt more confident to position themselves for grants. Program evaluations also showed that educators needed additional training on how to create partnerships. A second workshop, Are You Partnership Ready?, addresses this need, increasing participants' confidence and skills …

Food Insecurity Measurement And Prevalence Estimates During The Covid-19 Pandemic In A Repeated Cross-Sectional Survey In Mexico, Pablo Gaitán-Rossi, Mireya Vilar-Compte, Graciela Teruel, Rafael Pérez-Escamilla

Department of Public Health Scholarship and Creative Works

Objective: To validate the telephone modality of the Latin American and Caribbean Food Security Scale (ELCSA) included in three waves of a phone survey to estimate the monthly household food insecurity prevalence during the COVID-19 pandemic in Mexico. Design: We examined the reliability and internal validity of the ELCSA scale in three repeated waves of cross-sectional surveys with Rasch models. We estimated the monthly prevalence of food insecurity in the general population and in households with and without children and compared them with a national 2018 survey. We tested concurrent validity by testing associations of food insecurity with socio-economic status …

Seedextractor: An Open-Source Gui For Seed Image Analysis, Feiyu Zhu, Puneet Paul, Waseem Hussain, Kyle Wallman, Balpreet K. Dhatt, Jaspreet Sandhu, Larissa Irvin, Gota Morota, Hongfeng Yu, Harkamal Walia

Department of Agronomy and Horticulture: Faculty Publications

Accurate measurement of seed size parameters is essential for both breeding efforts aimed at enhancing yields and basic research focused on discovering genetic components that regulate seed size. To address this need, we have developed an open source graphical user interface (GUI) software, SeedExtractor that determines seed size and shape (including area, perimeter, length, width, circularity, and centroid), and seed color with capability to process a large number of images in a time-efficient manner. In this context, our application takes 2 s for analyzing an image, i.e., significantly less compared to the other tools. As this software is open-source, it …

Maternal And Newborn Health Risks Of Climate Change: A Call For Awareness And Global Action, Nathalie Roos, Sari Kovats, Shakoor Hajat, Veronique Filippi, Matthew Chersich, Stanley Luchters, Fiona Scorgie, Britt Nakstad, Olof Stephansson, Chamnha Consortium

Population Health, East Africa

Climate change represents one of the largest global health threats of the 21st century with immediate and long‐term consequences for the most vulnerable populations, especially in the poorest countries with the least capacity to adapt to climate change. Pregnant women and newborns are increasingly being recognized as vulnerable populations in the context of climate change. The effects can be direct or indirect through heat stress, extreme weather events and air pollution, potentially impacting both the immediate and long‐term health of pregnant women and newborns through a broad range of mechanisms. In 2008, the World Health Organization passed a resolution during …

White Paper On Ophthalmic Imaging For Choroidal Nevus Identification And Transformation Into Melanoma, Carol Shields, Sara E. Lally, Lauren Dalvin, Mandeep Sagoo, Marco Pellegrini, Swathi Kaliki, Ahmet Kaan Gündüz, Minoru Furuta, Prithvi Mruthyunjaya, Adrian T. Fung, Jay S. Duker, Sara M. Selig, Antonio Yaghy, Sandor R. Ferenczy, Malvina B. Eydelman, Mark S. Blumenkranz

Wills Eye Hospital Papers

Purpose: To discuss the evolution of noninvasive diagnostic methods in the identification of choroidal nevus and determination of risk factors for malignant transformation as well as introduce the novel role that artificial intelligence (AI) can play in the diagnostic process. Methods: White paper. Results: Longstanding diagnostic methods to stratify benign choroidal nevus from choroidal melanoma and to further determine the risk for nevus transformation into melanoma have been dependent on recognition of key clinical features by ophthalmic examination. These risk factors have been derived from multiple large cohort research studies over the past several decades and have garnered widespread use …

Microbiome: Role And Functionality In Human Nutrition Cycle, Fahad Alhusain

Saudi Medical Journal

ABSTRACT Microbes are present almost everywhere on this Earth. Humans harbor microbes in various organs, including skin, gut, mouth, and nose. Among these, the gut region has the highest population of microbes. Gut microbiota is directly linked with homeostasis, and a minor change in their numbers predisposes humans to ailments. Notably, the role of the microbial population in the digestive tract directly contributes to body weight. Sometimes, lifestyle changes or antibiotics intake to manage certain infections are associated with disturbance in the gut microflora. Several scientific studies allude to the obesity linkage with disturbed intestinal microflora. This review mainly focuses …

Sociodemographic And Clinical Predictors Of Refractory Type 2 Diabetes Patients: Findings From A Case-Control Study, Turki J. Alharbi, Ayla M. Tourkmani, Abdulaziz Bin Rsheed, Yasser K. Alotaibi

Saudi Medical Journal

Objectives: To identify the sociodemographic and clinical predictors of uncontrolled diabetic patients, to identify high-risk and people with impaired glycemic control, to establish more effective strategies for reducing morbidity and mortality. Methods: This case-control study of 8209 enrolled patients were included from the diabetes registry by Chronic Illness Center (CIC), Family and Community Medicin, Prince Sultan Military Medical City, Riyadh Saudi Arabia between February 2019 and February 2020. Cases are defined as patients with type II refractory diabetes having persistent HbA1c >9, not reach adequate glycemic control despite intensified therapy under specialist care (CIC) for at least 6 months. Controls …

Percutaneous Endoscopic Gastrostomy In Children: A Single Center Experience In Saudi Arabia, Faisal A. Alhaffaf, Awad S. Alqahtani, Abdulrahman A. Alrobyan, Sarah N. Alqubaisi, Bashar A. Ahmad, Mohammad R. Almutairi, Sami A. Wali, Hamoud A. Alhebbi

Saudi Medical Journal

Objectives: To evaluate the demographic data and complications in children who had undergone percutaneous endoscopic gastrostomy (PEG) over 9 years period. Methods: The demographic data, complications, length of hospital admission related to PEG insertion and follow-up findings of 39 patients who had undergone percutaneous endoscopic gastrostomy using the standard pull-through technique between 2011 and 2020 were examined. The study took place at the Gastroenterology Division, Department of Pediatrics, Prince Sultan Military Medical City, Riyadh, Saudi Arabia Results: The most common indications of feeding with a gastrostomy tube include neurological diseases (n=30, 76.9%), followed by metabolic disorders (n=3, 7.69%), chronic diarrhea …

Borderplex Business Barometer, Volume 5, Number 2, Thomas M. Fullerton Jr., Steven L. Fullerton, Ana Gutierrez Zubiate, Ignacio Santana

Border Region Modeling Project

No abstract provided.

Anti-Nlrp3 Inflammasome Natural Compounds: An Update, Baolong Liu, Jiujiu Yu

Department of Nutrition and Health Sciences: Faculty Publications

The nucleotide-binding domain and leucine-rich repeat related (NLR) family, pyrin domain containing 3 (NLRP3) inflammasome is a multimeric protein complex that recognizes various danger or stress signals from pathogens, the host, and the environment, leading to activation of caspase-1 and inducing inflammatory responses. This pro-inflammatory protein complex plays critical roles in pathogenesis of a wide range of diseases including neurodegenerative diseases, autoinflammatory diseases, and metabolic disorders. Therefore, intensive efforts have been devoted to understanding its activation mechanisms and to searching for its specific inhibitors. Approximately forty natural compounds with anti-NLRP3 inflammasome properties have been identified. Here, we provide an update …