Digital Commons Network^™

Diet Quality And Risk Of Lung Cancer In The Multiethnic Cohort Study, Song-Yi Park, Carol J. Boushey, Yurii B. Shvetsov, Michael David Wirth Msph,Ph.D., Nitin Shivappa Ph.D., James R. Hébert Sc.D., Christopher A. Haiman, Lynee R. Wilkens, Loic Le Marchand

Faculty Publications

Diet quality, assessed by the Healthy Eating Index-2015 (HEI-2015), the Alternative Healthy Eating Index-2010 (AHEI-2010), the alternate Mediterranean Diet (aMED) score, the Dietary Approaches to Stop Hypertension (DASH) score, and the Dietary Inflammatory Index (DII®), was examined in relation to risk of lung cancer in the Multiethnic Cohort Study. The analysis included 179,318 African Americans, Native Hawaiians, Japanese Americans, Latinos, and Whites aged 45–75 years, with 5350 incident lung cancer cases during an average follow-up of 17.5 ± 5.4 years. In multivariable Cox models comprehensively adjusted for cigarette smoking, the hazard ratios (95% confidence intervals) for the highest vs. lowest …

Association Between Appendicular Skeletal Muscle Index And Leukocyte Telomere Length In Adults: A Study From National Health And Nutrition Examination Survey (Nhanes) 1999-2002, Lingzhi Chen, Nitin Shivappa Mbbs, Mph, Ph.D., Xiuxun Dong, Jinjing Ming

Faculty Publications

Background

A higher body mass index (BMI) is associated with shorter telomeres. The loss of muscle mass with aging is associated with adverse outcomes. The appendicular skeletal muscle index (ASMI) is currently used to quantify muscle mass.

Objective

We investigated the association of the ASMI with leukocyte telomere length in adult Americans.

Methods

This cross-sectional study used the National Health and Nutrition Examination Survey (NHANES) 1999–2002 dataset. Body composition was measured by dual-energy X-ray absorptiometry. Low muscle mass was defined using sex-specific thresholds of the appendicular skeletal muscle mass index (ASMI). The telomere-to-single-copy gene ratio (T/S ratio) was converted to …

Worrisome Weight Gain: How Stress Affects Eating Behavior, Madison Ladd

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

It's Not You, It's Me (Your Genes), Gillian Heckler

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Locally Produced Foods, Celina Rodriguez, Abigail O'Brien, Aligi Ciancio

Student Work

A locally-produced diet is more sustainable than other diets.

Endogenous Mechanisms Regulating Myeloid Cell Mediated Inflammation During Acute Lung Injuries, Nathaniel Berg

Dissertations and Theses (Open Access)

Acute lung injuries (ALI) can result from both direct insults (e.g. pneumonia or inhalation injury), or systemic conditions such as sepsis or trauma. Current treatment options for patients are limited to supportive care and novel approaches are urgently needed. Appreciating the role of excessive inflammation that underlies the pathophysiology of ALI, we sought to identify endogenous mechanisms that dampen inflammation. Here we investigated two pathways that worked to limit excessive pulmonary inflammation in myeloid cells using a mouse model of sepsis-associated ALI. In the first approach we screened for microRNAs during the recovery phase of ALI that could potentially regulate …

Unraveling Host-Gut Microbiota Dialogue And Its Impact On Response To Immune Checkpoint Blockade, Alexandria Cogdill

Dissertations and Theses (Open Access)

Cancer is a disease with only one degree of separation, affecting one in two men and one in three women in their lifetimes; accounting for 1 of every 6 deaths. While cancer mortality rates continue to improve, incidence rates are expected to rise and shift through 2050 due to epidemiological and demographic transitions worldwide. As such, it is imperative to continue to investigate and improve our understanding of both disease etiology and hallmarks of response to treatment. Currently, conventional therapies include, but are not limited to, surgery, chemotherapy, and radiotherapy. However, within the past decade, major advances have been made …

Investigating Barriers Experienced By Underrepresented Minorities In Becoming A Competitive Genetic Counseling Applicant, Katie Huang

Dissertations and Theses (Open Access)

Representation for both racial/ethnic and gender identity minorities in genetic counseling (GC) remains the lowest among similar healthcare professions. Barriers that underrepresented minority (URM) individuals face in becoming a competitive GC applicant have not yet been described. Academic capital (AC) is a theoretical framework describing the social processes necessary for individuals to navigate and succeed in higher education. This study aimed to characterize barriers experienced by applicants who self-identify as underrepresented and to explore how AC could identify areas for intervention. Prospective GC applicants for the 2021/2022 cycles were recruited to complete an anonymous online survey in Qualtrics through a …

Amino Acid Metabolism And Autophagy In Skeletal Development And Homeostasis, Akiko Suzuki, Junichi Iwata

Faculty, Staff and Student Publications

Bone is an active organ that is continuously remodeled throughout life via formation and resorption; therefore, a fine-tuned bone (re)modeling is crucial for bone homeostasis and is closely connected with energy metabolism. Amino acids are essential for various cellular functions as well as an energy source, and their synthesis and catabolism (e.g., metabolism of carbohydrates and fatty acids) are regulated through numerous enzymatic cascades. In addition, the intracellular levels of amino acids are maintained by autophagy, a cellular recycling system for proteins and organelles; under nutrient deprivation conditions, autophagy is strongly induced to compensate for cellular demands and to restore …

Genomics-Assisted Breeding For Grain Yield And Composition In Sorghum, Sirjan Kumar Sapkota

All Dissertations

Cereal grains provide over half of the total calories for human and animal nutrition. Sorghum [Sorghum bicolor (L.) Moench] is the fifth most important cereal grain in the world and a source of staple for over half a billion people in the semi-arid tropics. As human population is projected to become nine billion by middle of this century, crop production needs to increase by 70% to 100% to meet the increasing demand for food. The advancement in genomic technologies and their application in breeding has potential to assure food security. The objectives of this study was to explore application of …

Consumer Preferences For Value Added Products: A Case Study For South Carolina, English Lane Ratliff

All Dissertations

This study utilized an online survey administered to South Carolina (SC) consumers in conjunction with a discrete choice modeling approach to examine: i) the knowledge and degree of familiarity with both the USDA Certified Organic and the Certified Naturally Grown labels, ii) the impact of several factors including demographic characteristics, purchasing behaviors, and frequency of organic consumption on consumer’s preferences and Willingness to Pay (WTP) for organic products in South Carolina. This study also includes a Meta-Analysis of WTP for organic products. The first chapter analyzes familiarity of two different labels; USDA Certified Organic and the Certified Naturally Grown. This …

Identifying Effective Teaching And Recruitment Strategies Used By Efnep In Reaching Limited Income Audiences In The United States, Alexandria Mcleod

Graduate Theses and Dissertations

The two articles presented in this thesis used a researcher-developed literature-based survey instrument to collect data on the Expanded Food and Nutrition Education Program (EFNEP) in the United States. Data was collected on methods of teaching, communication technologies used, recruitment strategies, barriers to attending classes, and program assistant demographic data. There were 803 program assistants working during the 2018-2019 program year. There were 346 program assistants who completed the 35-question survey instrument during data collection.

The first article focused on identifying effective teaching strategies used to increase program engagement by collecting data on program characteristics, methods of teaching, and educational …

Economic Feasibility Of Sub-Surfaced Poultry Litter, James Timothy Stults

Graduate Theses and Dissertations

Livestock producers routinely spread fertilizer or broadcast poultry litter to improve forage production. With poultry litter widely available across the Southeastern United States and a cheaper source of plant nutrition than fertilizer when proximal to application sites, the novel application of litter below the soil surface, while costly, allows for greater nutrient retention than broadcasting. Since quantifying costs and benefits of sub-surface litter application (SSLA) is complex, we develop and present a spreadsheet tool for automated comparison between SSLA, fertilizer, and broadcasted litter for user-specific scenarios involving equipment choices (new, used, custom), desired nutrient needs for crops grown, litter nutrient …

Direct Hyperbilirubinemia In Infants With Trisomy 13 And 18, Jeffrey Kepple, Eric Peeples

Child Health Research Institute Pediatric Research Forum

Background: Survival in trisomy 13 (T13) and 18 (T18) has increased in recent years, but little is known about the prevalence and management of the non-lethal complications in these populations.

Significance of Problem: A subjectively high rate of direct hyperbilirubinemia (DH) was noted at Children’s Hospital & Medical Center compared to the general population. Defining the prevalence, timing, and risk factors for DH will allow for the development of screening and management guidelines.

Hypothesis, Problem or Question: We hypothesized that infants with T13 and T18 would have high rates of DH, with no significant difference in prevalence between …

Fit For Life: Educating About A Healthy Lifestyle In Omaha Elementary Schools, Emilee Greager, Mary Conklin, Jordan Nustad, Tyler Bendrick, Haley Bremer, Tavishi Chopra, Jane Driano, Connor Eggleston, Lily Foley, Jeffrey Kepple, Ryan Leuty, Taylor Mattice, Alison Mause, Elizabeth Mause, Molly Olsen, Breanne Parets, Heerali Patel, Thomas Pennington, Miranda Prints, Eva Schaible, Christopher Toivonen, Grace Vitek, Claire Willman, Allen Zheng, Kody Moffatt

Child Health Research Institute Pediatric Research Forum

Background: The prevalence of childhood obesity is increasing across the country. Health education at a young age is critical for children to establish healthy habits. The Fit for Life program is put together by Creighton medical students to inspire elementary students to lead a healthy lifestyle. The curriculum integrates physical exercise, real organ demonstrations, emotional wellness exercises, and nutritious meal building to model and encourage healthy habits.

Methods: Over four weeks, medical students taught the 4^th and 5^th graders of two Omaha schools over live video while they followed along with hands-on activities. Before and after the program, …

Severe Colitis And Malnutrition In Association With Neonatal Hemophagocytic Lymphohistiocytosis, Laura Tarantino

Child Health Research Institute Pediatric Research Forum

Introduction: Hemophagocytic lymphohistiocytosis (HLH) is a rare syndrome of overwhelming immune activation causing multiorgan dysfunction that may be genetic and/or acquired. Patients with familial HLH often present by one year of age, though most are asymptomatic in the first month of life. We present the case of a neonate with diarrhea and malnutrition who developed signs and symptoms consistent with a clinical diagnosis of HLH.

Case: A neonate born at 35 5/7 weeks was transferred to a Level IV neonatal intensive care unit at 39 4/7 weeks for failure to thrive. Though feeding adequately and non-dysmorphic, he had …

A New All-Natural Wound Treatment Gel Shows Strong Inhibitory Activity Against Staphylococcus Aureus And Other Wound Pathogens, Tasha K. Nelson

Electronic Theses and Dissertations

Skin related injuries are some of the most dangerous forms of wounds. In addition to treating the wound itself, health care providers must be cautious of microbial infections. In this study, we evaluate a novel all-natural antimicrobial gel compound (AMG) designed to kill planktonic bacteria, penetrate bacterial biofilms, and accelerate wound healing. In -vitro experiments demonstrate that AMG is effective in inhibiting planktonic growth and biofilm development of eight common pathogens. LIVE/DEAD staining and confocal microscopy reveal that planktonic growth and three-dimensional structure of biofilms were significantly reduced. Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) was used to investigate a small …

Exploration Of Antimicrobial And Cell Proliferation Properties Of Nanofibers Incorporating Nopal (O. Cochenillifera) Extract, Cristobal Rodriguez

Theses and Dissertations

This study focused on the fabrication of Forcespinning® nanofibers composed of Opuntia cochenillifera, ‘nopal’, mucilage (N) extract, chitosan (CH), and pullulan (PL) (N/CH/PL) were developed with an optimum fiber average diameter of 406±127 nm, and studied for their ability to sustain adhesion and proliferation of mouse embryonic fibroblast (NIH 3T3) cells. After a 6-day incubation period, N/CH/PL nanofibers displayed robust cell proliferation, while also exhibiting inhibitory properties through an N extract dip-coating process against gram-negative bacteria Escherichia coli in a 24 h bacterial growth study. A demonstration of integrated natural bioactive compounds with combined biodegradable polymers, provide an enhanced …

May 2021, Swosu Bulldog Wellness Committee

SWOSU BULLDOG WELLNESS

National Osteoporosis Month

About 54 million Americans have osteoporosis and low bone mass, placing them at increased risk for osteoporosis.

American Stroke Awareness Month

Stroke is dangerous and deadly, but you can control and treat several risk factors for it.

Emotion Regulation Among Adults With Asthma: Links With Short-Acting Inhaler Medication Overuse And Utilization Of Acute Medical Care, Victoria A. Green

Honors Theses

Effective control of asthma symptoms requires daily self-management activities, including use of short-acting or “rescue” inhaled medications. Overuse of short-acting inhaled medications, such as albuterol, can have negative side-effects, including respiratory infections and worse asthma symptom control. Existing research suggests that emotion plays an important role in airway inflammation and asthma symptom control. The objective of this study was to determine whether difficulties regulating emotion was associated with overuse of short-acting inhaled medications and acute medical care usage in adults with asthma. The sample included 401 adults with asthma recruited from an online panel of adults with chronic respiratory disease. …

Predisposition Of Disordered Eating Among Women At The University Of Mississippi, Lucy Williams

Honors Theses

The intention of this project was to evaluate the attitudes, feelings and behaviors towards eating and food in Panhellenic sorority students, compared to women not in a sorority. The effect of other factors like grade point average, financial income, and the value of being viewed as attractive was also investigated. Two thousand sorority members and two thousand non-sorority members received a survey administered through Qualtrics to email addresses provided by the Office of Institutional Research, Effectiveness, and Planning at the University of Mississippi. Out of this group, 809 students participated in the survey. The survey consisted of questions from the …

Perceived Adult/Child Health And Diet By Snap Usage And Food Security In A Rural, Appalachian Mississippi Community, Georgia Inglis

Honors Theses

This study examined if there were differences in perceived adult health score, perceived adult diet score, parent-perceived child health score, and parent-perceived child diet score by SNAP usage and food security in a rural, Appalachian Mississippi community. Adults (n=1084) with elementary school- aged children were surveyed in a rural, Appalachian Mississippi school district. Demographic, household adult food security (USDA 10-item measure), and perceived health and dietary data were collected. Using IBM SPSS version 24, demographic statistics were calculated to summarize data. Independent samples t-test and one-way ANOVA with Tukey post-hoc test was utilized to assess for differences between groups. P.05) …

Challenges And Benefits Experienced By Mississippi Schools In The Adoption Of Farm To School Programs, Manuel Aldair Franco Pech

Honors Theses

Mississippi obesity rates are the second highest in the United States. An appropriate target group to combat the state’s high obesity rates are school age children (ages 18 and under), because healthy eating habits developed at this age translate into adult years. An avenue to encourage and develop healthy eating habits are Farm to School (F2S) programs, which provide in-school accessibility to healthy, locally produced foods. The objective of this study was to analyze the results from the 2015 United States Department of Agriculture’s (USDA) F2S Census, which collected details regarding F2S participation across the country, to determine the benefits …

Being Female And Indigenous: Barriers To Reducing Bolivia's Maternal Mortality Rates Under Evo Morales, Channell Cole

Honors Theses

This thesis seeks to answer the question: What are the barriers to attempts to reduce Bolivia’s maternal mortality rate under Evo Morales? While Morales’ presidency began in 2006, the timeline is from 2004 to the present to account for changes due to his policy. Using activity theory and social capital theory, I argue that machismo and racism are two social factors that are barriers to efforts to reduce the maternal mortality rate. Machismo manifests itself uniquely in Bolivia, as I argue through a comparison to Paraguay. Machismo is also riddled with a history of anti-indigenous racism. I examine the Rockefeller …

Refugees Not Welcome Here: An Analysis Of Human Rights Transgressions Under The Migrant Protection Protocols, Claire Haxton

Honors Theses

On December 20, 2018 the Trump administration released a statement announcing the signing of an executive order implementing a new asylum program called the Migrant Protection Protocols. Under this legislation, third party nationals arriving at the United States’ southwestern border seeking asylum would be forced to remain in Mexico throughout the processing of their asylum application. This new protocol promised to limit false asylum cases and streamline meritorious applications while preventing migrants from exploiting loopholes in the former asylum system. However, critics argue that the Migrant Protection Protocols further endanger refugees and infringe on their human rights. This study aims …

Multi-Response Surface Optimisation Of Extrusion Cooking To Increase Soluble Dietary Fibre And Polyphenols In Lupin Seed Coat, Liezhou Zhong, Zhongxiang Fang, Mark L. Wahlqvist, Jonathan M. Hodgson, Stuart K. Johnson

Research outputs 2014 to 2021

The seed coat of the legume lupin which is rich in insoluble dietary fibre is a major by-product in human food applications. Extrusion cooking has been demonstrated to increase desirable soluble dietary fibre in the Australian sweet lupin seed coat. In this study, processing condition of twin-screw extrusion cooking was optimised using a central composite rotatable design to increase soluble dietary fibre in lupin seed coat from 44.17 g/kg up to 113.69 g/kg dry basis. The high levels of polyphenols in the seed coat were retained. The optimal extrusion conditions which achieved maximum levels of soluble dietary fibre, total free …

Increasing Parents Knowledge On Reducing Child Lead Exposure Through Education Provided By Community Health Workers In El Paso, Texas, Jaleen Gabrielle Avila

Open Access Theses & Dissertations

Background and significance: Childhood lead exposure continues to be a significant public health concern, especially within Hispanic and Latino communities. Exposure to environmental lead is associated with various adverse health outcomes among children. Unfortunately, parents may have limited knowledge on the topic of lead exposure and may be unaware of screening and mitigation options available to their families. Research on culturally competent educational interventions that focus on increasing parents' knowledge on reducing childhood lead exposure is limited, particularly within Hispanic border communities. This study aimed to assess if a brief education session provided by Community Health Workers increased parents' knowledge …

Stability Of Blood Lead Levels In Children With Chronic Low-Level Lead Absorption, Michelle Del Rio

Open Access Theses & Dissertations

Background and Significance: Despite the many historical efforts by the U.S. to reduce lead (Pb) in the environment, childhood Pb poisoning continues to be a public health issue today. Pb has been identified as a child hazard because children are highly vulnerable to the effects even at lower levels of exposure (blood lead levels (BLLs) < 10 μg/dL), and these effects can be physical, cognitive, and behavioral. Current state and federal blood lead level screening guidelines for identifying exposed children are based on assumptions that BLLs < 10 μg/dL will remain stable or decline over time (with age); disregard the effects of lowest-range Pb exposure; and disregard Pb levels in children older than approximately age 6. We have observed in past clinical studies that in one U.S./Mexico border community, children in high-risk neighborhoods experienced substantially higher proportions of elevated blood lead levels (CDC reference level of ≥ 5 μg/dL) than the rest of the U.S., and a large proportion of children had detectable blood lead levels. To test current policy assumptions regarding child blood lead level screening, this study examined whether time and/or other possible factors over time, predicted child blood lead levels in children with chronic low-level Pb absorption. Whether time was a significant predictor was examined, and also whether age, sex, and living in families with incomes below the U.S. poverty line, living in an older home, and living near industries predicted child blood lead levels.

Aims and Objectives: Changes in current policy must be evidence-based. The over-arching goal of this study was to test current assumptions that one blood lead level test is sufficient to rule out child lead exposure, and that lead exposure and risk of lead exposure, reliably …

Patterns Of Use In A Division I University Fueling Station Before And After Implementing A Nutrition Education Intervention, Cady L. Peters

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Well-timed nutrition strategies are a well-established way to improve athletic performance and minimize recovery time, however, athletes often do not prioritize nutrition as a strategy to gain an edge over their competitors. Even with a resource such as a Fueling Station, which provides athletes with nutrient dense, convenient pre- and post-workout snacks, athletes still struggle understanding which foods are an appropriate choice for their purpose of eating.

The purpose of this research was to examine the changes in the appropriateness of the athlete’s meal choices at the Fueling Station based on their macronutrient distribution and timing of workout or training …

Fatty Acid Composition Of Forages And Their Effect On The Fatty Acid Composition In Beef Cattle, Britney G. Allen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This study focused on how diet changes the rumen microbiome in the cattle and the effects of that on the long chain fatty acids (LCFA) by microbes in the rumen, and on the short chain fatty acids (SCFA) these microbes produce from feed carbohydrates like fiber and starch. The abundance of bacteria belonging to the phyla Tenericutes and Proteobacteria increased in response to high-fiber or high-starch diets, respectively. The production of two SCFA was positively correlated with the presence of increased Tenericutes (acetate) and Proteobacteria (propionate). A greater acetate to propionate ratio is associated with elevated production of enteric methane …