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2021

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Why Is Safe Food Handling Important? [English/Arabic], Celina Wille Jul 2021

Why Is Safe Food Handling Important? [English/Arabic], Celina Wille

All Current Publications

This handout, available here in both English and Arabic, provides information to prevent illness through safe food handling practices.


Why Is Safe Food Handling Important? [English/Somali], Celina Wille Jul 2021

Why Is Safe Food Handling Important? [English/Somali], Celina Wille

All Current Publications

This handout, available here in both English and Somali, provides information to prevent illness through safe food handling practices.


Why Is Safe Food Handling Important? [English/Karen], Celina Wille Jul 2021

Why Is Safe Food Handling Important? [English/Karen], Celina Wille

All Current Publications

This handout, available here in both English and Karen, provides information to prevent illness through safe food handling practices.


Why Is Safe Food Handling Important? [English/Spanish], Celina Wille Jul 2021

Why Is Safe Food Handling Important? [English/Spanish], Celina Wille

All Current Publications

This handout, available here in both English and Spanish, provides information to prevent illness through safe food handling practices.


Why Is Safe Food Handling Important? [English/Tigrinya], Celina Wille Jul 2021

Why Is Safe Food Handling Important? [English/Tigrinya], Celina Wille

All Current Publications

This handout, available here in both English and Tigrinya, provides information to prevent illness through safe food handling practices.


Food Supply Chains In Developed Countries And Livestock Production Systems, Alan Mcdermott Jul 2021

Food Supply Chains In Developed Countries And Livestock Production Systems, Alan Mcdermott

IGC Proceedings (1977-2023)

No abstract provided.


Increasing Obesity Odds Among Foreignborn New Yorkers Are Not Explained By Eating Out, Age At Arrival, Or Duration Of Residence: Results From Nyc Hanes 2004 And 2013/2014, Margrethe F. Horlyck-Romanovsky, Sean J. Haley Jul 2021

Increasing Obesity Odds Among Foreignborn New Yorkers Are Not Explained By Eating Out, Age At Arrival, Or Duration Of Residence: Results From Nyc Hanes 2004 And 2013/2014, Margrethe F. Horlyck-Romanovsky, Sean J. Haley

Publications and Research

Background: Among the foreign-born in the United States (US) dietary acculturation and eating out may increase obesity risk. Using the 2004 (N = 1952) and 2013/14 (N = 1481) New York City (NYC) Health and Nutrition Examination Surveys, we compared for the foreign-born and US-born by survey year: 1) odds of obesity; 2) association between eating out and obesity and 3) effect of age at arrival and duration of residence among the foreign-born. Weighted logistic regression estimated odds of obesity.

Results: Compared to the US-born, the foreign-born had lower odds of obesity in 2004, (aOR = 0.51 (95%CI 0.37– 0.70), …


Gaining Glycemic Control In Patients With Uncontrolled Type 2 Diabetes In Rural Health, Demetric Childs-Hicks Jul 2021

Gaining Glycemic Control In Patients With Uncontrolled Type 2 Diabetes In Rural Health, Demetric Childs-Hicks

Student Scholarly Projects

Practice Problem: Diabetes is a significant global healthcare problem. The number of individuals diagnosed with Type 2 Diabetes (T2D) is alarmingly high and the numbers are steadily increasing. Because of various barriers, individuals living in rural communities are at greater risk of having uncontrolled T2D.

PICOT: The PICOT question that guided this project was “Will patients with uncontrolled T2D in rural health have better control of their glucose levels when using telephone or web-based monitoring by healthcare providers than patients with uncontrolled T2D in rural health who do not use technology to achieve glycemic control as evidenced by lower pre-prandial …


A Look Into User Privacy And Third-Party Applications In Facebook, Sovantharith Seng, Mahdi Nasrullah Al-Ameen, Matthew Wright Jul 2021

A Look Into User Privacy And Third-Party Applications In Facebook, Sovantharith Seng, Mahdi Nasrullah Al-Ameen, Matthew Wright

Computer Science Faculty and Staff Publications

Purpose

A huge amount of personal and sensitive data are shared on Facebook, which makes it a prime target for attackers. Adversaries can exploit third-party applications connected to a user’s Facebook profiles (i.e. Facebook apps) to gain access to this personal information. Users’ lack of knowledge and the varying privacy policies of these apps make them further vulnerable to information leakage. However, little has been done to identify mismatches between users’ perceptions and the privacy policies of Facebook apps. This paper aims to address this challenge in the work.

Design/methodology/approach

The authors conducted a lab study with 31 participants, where …


Barriers To Access Of Healthcare Services For Rural Women – Applying Gender Lens On Tb In A Rural District Of Sindh, Pakistan, Shifa Salman Habib, Wafa Zehra Jamal, Syed Muhammad Asad Zaidi, Junaid Ur-Rehman Siddiqui, Hira Mustafa Khan, Jacob Creswell, Srichand Batra, Anna Versfeld Jul 2021

Barriers To Access Of Healthcare Services For Rural Women – Applying Gender Lens On Tb In A Rural District Of Sindh, Pakistan, Shifa Salman Habib, Wafa Zehra Jamal, Syed Muhammad Asad Zaidi, Junaid Ur-Rehman Siddiqui, Hira Mustafa Khan, Jacob Creswell, Srichand Batra, Anna Versfeld

Community Health Sciences

Background: Women in rural districts of Pakistan face numerous barriers to healthcare, rendering gender-responsive health programming important, including for Tuberculosis (TB). This study was conducted to assess the general understanding of TB and of access to healthcare for women, as a first step towards implementation of a gender responsive TB programme in TandoAllayar, a rural district of Pakistan.
Methods: A total of 36 participants were interviewed. The focus group discussion guide comprised of questions on: (1) family/household dynamics (2) community norms (3) healthcare system (4) women’s access to healthcare (5) TB Awareness;, and (6) women’s access to TB Care.
Results: …


Bovine Mammary Alveolar Mac-T Cells Afford A Tool For Studies Of Bovine Milk Exosomes In Drug Delivery, Mojisola Ogunnaike Jul 2021

Bovine Mammary Alveolar Mac-T Cells Afford A Tool For Studies Of Bovine Milk Exosomes In Drug Delivery, Mojisola Ogunnaike

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

Bovine milk exosomes (BMEs) have attracted attention as vehicles for delivering RNA therapeutics. BMEs originate in mammary alveolar cells. Here, we determined whether bovine mammary alveolar MAC-T cells are a promising tool to assess RNA delivery by BMEs. MAC-T cells exosomes (MAC-T BMEs) and BMEs were harvested by differential ultracentrifugation. Exosome size, morphology, microRNA content and marker proteins were assessed using nanoparticle tracking analysis, transmission electron microscopy, real-time PCR and immunoblot analysis, respectively. MAC-T cells were genetically engineered to secrete MAC-T BMEs endogenously labeled with a near-infrared fluorescent protein and tissue distribution was compared to fluorophore-labeled BMEs following intravenous injection …


Acceptability Of Intervention Design Factors In Mhealth Intervention Research: Experimental Factorial Study., Frank T. Materia, Joshua M. Smyth Jul 2021

Acceptability Of Intervention Design Factors In Mhealth Intervention Research: Experimental Factorial Study., Frank T. Materia, Joshua M. Smyth

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: With the growing interest in mobile health (mHealth), behavioral medicine researchers are increasingly conducting intervention studies that use mobile technology (eg, to support healthy behavior change). Such studies' scientific premises are often sound, yet there is a dearth of implementational data on which to base mHealth research methodologies. Notably, mHealth approaches must be designed to be acceptable to research participants to support meaningful engagement, but little empirical data about design factors influencing acceptability in such studies exist.

OBJECTIVE: This study aims to evaluate the impact of two common design factors in mHealth intervention research-requiring multiple devices (eg, a study …


Potential Benefits Of Bovine Colostrum In Pediatric Nutrition And Health, Per Torp Sangild, Caitlin Vonderohe, Valeria Melendez Hebib, Douglas G Burrin Jul 2021

Potential Benefits Of Bovine Colostrum In Pediatric Nutrition And Health, Per Torp Sangild, Caitlin Vonderohe, Valeria Melendez Hebib, Douglas G Burrin

Children’s Nutrition Research Center Staff Publications

Bovine colostrum (BC), the first milk produced from cows after parturition, is increasingly used as a nutritional supplement to promote gut function and health in other species, including humans. The high levels of whey and casein proteins, immunoglobulins (Igs), and other milk bioactives in BC are adapted to meet the needs of newborn calves. However, BC supplementation may improve health outcomes across other species, especially when immune and gut functions are immature in early life. We provide a review of BC composition and its effects in infants and children in health and selected diseases (diarrhea, infection, growth-failure, preterm birth, necrotizing …


Intensive Hunting Pressure Changes Local Distribution Of Wild Boar, Jakub Drimaj, Jiří Kamler, Radim Plhal, Přemysl Janata, Zdeněk Adamec, Miloslav Homolka Jul 2021

Intensive Hunting Pressure Changes Local Distribution Of Wild Boar, Jakub Drimaj, Jiří Kamler, Radim Plhal, Přemysl Janata, Zdeněk Adamec, Miloslav Homolka

Human–Wildlife Interactions

Wild boar (Sus scrofa) is now an important species of wild ungulates in Central Europe. Next to conflicts of wild boar with agriculture, the main threat of wild boar presence lies in the expansion of African swine fever across Europe. The regulation of the wild boar population is complicated by the high reproduction rate and intelligent behavior of the species, which limits hunting effectiveness. We analyzed the spatial behavior of wild boar in an environment with a lack of natural food resources. The study area consisted of a forest complex (1,283 ha) with 2 areas. In the “risk” …


Reduced Fecundity In Free-Ranging Norway Rats After Baiting With A Liquid Fertility Control Bait, Gary W. Witmer, Stefanie Raymond-Whish Jul 2021

Reduced Fecundity In Free-Ranging Norway Rats After Baiting With A Liquid Fertility Control Bait, Gary W. Witmer, Stefanie Raymond-Whish

Human–Wildlife Interactions

Norway rats (Rattus norvegicus) cause extensive crop loss, infrastructure damage, and are vectors for zoonotic diseases. Due to reduced efficacy, environmental and animal welfare concerns related to traditional pest management tools, such as rodenticides, it is imperative to find new methods for controlling commensal rodents. Fertility control is emerging as a safe, humane, and effective method of long-term population management. Vinylcyclohexene diepoxide (VCD) and triptolide are 2 compounds that are known to target and inhibit ovarian function. Furthermore, triptolide debilitates spermatogenesis and sperm motility. We prepared liquid bait containing no active ingredients (control) or containing VCD (0.098%) and …


Prevalence Trend And Disparities In Rheumatoid Arthritis Among Us Adults, 2005–2018, Yingke Xu, Qing Wu Jul 2021

Prevalence Trend And Disparities In Rheumatoid Arthritis Among Us Adults, 2005–2018, Yingke Xu, Qing Wu

School of Public Health Faculty Research

Rheumatoid arthritis (RA) trends among US adults and disparities in RA patients in recent years have not been well described. We aimed to examine the trend of RA prevalence and disparities among US adults. Data from the National Health and Nutrition Examination Survey (NHANES) of the years 2005–2018 were analyzed to examine the self-reported RA prevalence trend. Age-adjusted RA prevalence stratified by race/ethnicity and socioeconomic status (SES), as well as associated linear trends, were calculated for both genders. The multivariable adjustment was used to evaluate the association between race, SES, and RA. During 2005–2018, there was no significant linear trend …


How Can A Non-Profit Empower Community Through Childcare?: An Analysis On The Impacts Childcare And Workforce Development Has On The Lives Of Immigrant Families, Jose Molina Jul 2021

How Can A Non-Profit Empower Community Through Childcare?: An Analysis On The Impacts Childcare And Workforce Development Has On The Lives Of Immigrant Families, Jose Molina

Student Research – Stevenson Center

No abstract provided.


Water Regulation For Enhancing Soil Quality Using Cactus Mucilage: A Theoretical And Experimental Analysis, Khuloud Alrashdi Jul 2021

Water Regulation For Enhancing Soil Quality Using Cactus Mucilage: A Theoretical And Experimental Analysis, Khuloud Alrashdi

USF Tampa Graduate Theses and Dissertations

As water is one of the primary sources of life, it is essential in an endless number of systems and processes to be utilized efficiently in nature and in practical applications. One of these applications includes farming, which depletes a lot of water as the water irrigation systems cover large soil areas. While water is a critical factor in growing crops, a question here stands, can the irrigation process be transformed? This is the overarching goal of my work since it is centered on studying if cactus mucilage, a natural substance, is capable of improving water absorption processes on crops …


That T-Rex Is Mine! A Note On The Montana Supreme Court Decision Murray V. Bej Minerals, Llc, Bryce Hayden Jul 2021

That T-Rex Is Mine! A Note On The Montana Supreme Court Decision Murray V. Bej Minerals, Llc, Bryce Hayden

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.


Geospatial Analysis Of Rurality And Food Banks In Appalachian Ohio, Cooper T. Johnson, Rebecca Fischbein, Kristin Baughman Jul 2021

Geospatial Analysis Of Rurality And Food Banks In Appalachian Ohio, Cooper T. Johnson, Rebecca Fischbein, Kristin Baughman

Journal of Appalachian Health

Introduction: Food insecurity is a problem for individuals across Ohio, including those living in Appalachia. Adequate access to resources that help combat food insecurity is important for these populations.

Purpose: To examine how rurality relates to food insecurity and need for food resources, as well as availability of those resources including food pantries and soup kitchens, in 15 northern Ohio Appalachian counties.

Methods: A cross-sectional study with a geographical analysis was conducted using data from the American Community Survey census data, County Health Rankings data, and regional foodbank websites.

Results: Rural counties had a higher ratio of potential clients per …


Addressing Diabetes Distress In Self-Management Programs: Results Of A Randomized Feasibility Study, Ranjita Misra, Samantha Shawley-Brzoska, Raihan Khan, Brenna O. Kirk, Sijin Wen, Usha Sambamoorthi Jul 2021

Addressing Diabetes Distress In Self-Management Programs: Results Of A Randomized Feasibility Study, Ranjita Misra, Samantha Shawley-Brzoska, Raihan Khan, Brenna O. Kirk, Sijin Wen, Usha Sambamoorthi

Journal of Appalachian Health

Background: West Virginia ranks 1st nationally in the prevalence of hypertension (HTN; 43.8%) and diabetes (16.2%). Patients with type 2 diabetes mellitus (T2DM) are distressed over physical and psychological burden of disease self-management.

Methods: This study investigated the effectiveness of an intervention to reduce diabetes distress and outcomes [glycemic control, blood pressure (BP)] among T2DM adults with comorbid HTN. Participants were randomized to a 12-week diabetes and hypertension self-management program versus a 3-month wait-listed control group. Trained health coaches and experts implemented the lifestyle program in a faith-based setting using an adapted evidence-based curriculum. Twenty adults with T2DM and HTN …


Diabetes Knowledge, Behaviors, And Perceptions Of Risk In Rural West Virginia Counties, Ranjita Misra, Sara Farjo, Renee Mcginnis, Megan Adelman Elavsky, Summer Kuhn, Catherine Morton-Mcswain Jul 2021

Diabetes Knowledge, Behaviors, And Perceptions Of Risk In Rural West Virginia Counties, Ranjita Misra, Sara Farjo, Renee Mcginnis, Megan Adelman Elavsky, Summer Kuhn, Catherine Morton-Mcswain

Journal of Appalachian Health

Introduction: A little less than half of American adults have diabetes or pre-diabetes. In 2016, West Virginia (WV) had the highest percentage (15.2%) of adults with diagnosed diabetes in the U.S.

Purpose: In partnership with the Health Sciences and Technology Academy (HSTA), a cross-sectional study was preformed to assess knowledge, behaviors, and perceptions of diabetes risk.

Methods: Data was collected by trained HSTA students and teachers who lived in rural counties in WV. Information was assessed using validated surveys, and HbA1c was obtained by utilizing professional point-of-care (Bayer) kits.

Results: Mean age and Body Mass Index (BMI) was 36.11±17.86 years …


Nontraumatic Injuries In The Ncaa: Collegiate Football Strength Coaches Should Exercise Caution This Off-Season, Andreas Stamatis, Marshall Magnusen Jul 2021

Nontraumatic Injuries In The Ncaa: Collegiate Football Strength Coaches Should Exercise Caution This Off-Season, Andreas Stamatis, Marshall Magnusen

International Journal of Exercise Science

International Journal of Exercise Science 14(6): 980-983, 2021. Strength and conditioning coaches were allegedly involved in pre-COVID-19 nontraumatic injuries/deaths (e.g., exertional heat illness, exertional rhabdomyolysis, cardiorespiratory failure) of NCAA (mainly football) student-athletes during off-season training sessions. During the COVID-19 health crisis, non-pharmaceutical interventions against the SARS-CoV-2 virus included suspension of NCAA seasons, which led to student-athletes exhibiting lower levels of mental health. All NCAA championships have now been reinstated. This summer the off-season is unique, because as several programs had stopped practicing/competing for several months, it may foster additional threats to the wellbeing of the student-athletes. Immediate supplementary action may …


Combined Physical Training Increases Plasma Brain-Derived Neurotropic Factor Levels, But Not Irisin In People Living With Hiv/Aids, Joice Cristina Dos Santos Trombeta, Roberto Carlos Vieira Junior, Cláudia Regina Cavaglieri, Ivan Luiz Padilha Bonfante, Jonato Prestes, Ramirez Alsamir Tibana, Morteza Ghayomzadeh, Vinicius Carolino Souza, Seyedahmad Seyedalinaghi, James Wilfred Navalta, Fabrício Azevedo Voltarelli Jul 2021

Combined Physical Training Increases Plasma Brain-Derived Neurotropic Factor Levels, But Not Irisin In People Living With Hiv/Aids, Joice Cristina Dos Santos Trombeta, Roberto Carlos Vieira Junior, Cláudia Regina Cavaglieri, Ivan Luiz Padilha Bonfante, Jonato Prestes, Ramirez Alsamir Tibana, Morteza Ghayomzadeh, Vinicius Carolino Souza, Seyedahmad Seyedalinaghi, James Wilfred Navalta, Fabrício Azevedo Voltarelli

International Journal of Exercise Science

International Journal of Exercise Science 14(3): 1004-1017, 2021. This study evaluated plasma levels of brain-derived neurotropic factor (BDNF), irisin, and lactate in people living with HIV/AIDS who completed a combined physical training program. Nineteen HIV+ participants (age: 39.60 ± 10.96 years; carrier time: 7.75 ± 7.88 years; time of ART: 6.41 ± 5.93 years) performed strength/aerobic training (combined physical training) in the same session for 8 weeks and levels of BDNF, irisin, and lactate were assessed. BDNF (pg/mL) was higher post-CPT (Pre: 1258.73 ± 372.30; Post: 1504.17 ± 322.30; p < 0.001). Irisin (ng/mL) showed no change (Pre: 115.61 ± 72.41; Post: 125.87 ± 81.14; p = 0.973). There was positive correlation between irisin …


Beta-Alanine Supplementation For Four Weeks Increases Volume Index And Reduces Perceived Effort Of Resistance-Trained Men: A Pilot Study., Julio Benvenutti Bueno De Camargo, Felipe Brigatto, Rafael Zaroni, Moises Germano, Raphael Conceicao, Alexandre Martins, Marcelo Aoki, Tiago Braz, Charles Lopes Jul 2021

Beta-Alanine Supplementation For Four Weeks Increases Volume Index And Reduces Perceived Effort Of Resistance-Trained Men: A Pilot Study., Julio Benvenutti Bueno De Camargo, Felipe Brigatto, Rafael Zaroni, Moises Germano, Raphael Conceicao, Alexandre Martins, Marcelo Aoki, Tiago Braz, Charles Lopes

International Journal of Exercise Science

International Journal of Exercise Science 14(2): 994-1003, 2021. The aim of the present study was to assess the short-term effects of four weeks of beta-alanine supplementation (BA) (6.4 g/day) on the total volume performed and perceived effort of resistance-trained individuals. Sixteen trained men (age: 27.3 ± 5.0 years, height: 1.78 ± 0.1 cm, total body mass: 84.3 ± 8.4 kg, RT experience: 5.9 ± 3.3 years) were allocated in one of the following groups: BA or Placebo (PLA). In addition, during the same period, participants were submitted to a resistance training program. Volume index (VI) and the rate of perceived …


Subjective Cognitive Decline Higher Among Sexual And Gender Minorities In The United States, 2015–2018, Jason D. Flatt, Ethan C. Cicero, Nickolas H. Lambrou, Whitney Wharton, Joel G. Anderson, Erin D. Bouldin, Lisa C. Mcguire, Christopher A. Taylor Jul 2021

Subjective Cognitive Decline Higher Among Sexual And Gender Minorities In The United States, 2015–2018, Jason D. Flatt, Ethan C. Cicero, Nickolas H. Lambrou, Whitney Wharton, Joel G. Anderson, Erin D. Bouldin, Lisa C. Mcguire, Christopher A. Taylor

Social and Behavioral Health Faculty Research

Introduction: Subjective cognitive decline (SCD) represents self-reported problems with memory, a possible early sign of dementia. Little is known about SCD among sexual and gender minority (SGM) adults who identify as lesbian, gay, bisexual, and/or transgender or gender non-binary. Methods: Data were weighted to represent population estimates from 25 states’ 2015–2018 Behavioral Risk Factor Surveillance System to describe SCD in adults ≥ 45 years by SGM status. Logistic regression tested associations between demographic and health conditions. Results: SCD prevalence was higher in SGM (15.7%; 95% confidence interval [CI]:13.1–18.2) than in non-SGM adults (10.5%; 95% CI:10.1–10.9; P < .0001). SGM adults with SCD were also more likely to report functional limitations due to SCD than non-SGM adults with SCD, 60.8% versus 47.8%, P =.0048. Differences in SCD by SGM status were attenuated after accounting for depression. Discussion: Higher prevalence of SCD in SGM adults highlights the importance of ensuring inclusive screenings, interventions, care services, and resources for SGM adults.


Poc In Lis Cohorts, Aidy Weeks, Ruby Nugent, Melanie Dixson, Niki Kirkpatrick, Mayra Corn Jul 2021

Poc In Lis Cohorts, Aidy Weeks, Ruby Nugent, Melanie Dixson, Niki Kirkpatrick, Mayra Corn

POC in LIS Summit

According to ALA Diversity Counts Survey (2012), librarians of color (African American, Asian American/Pacific Islander, Native American including Alaska Native, Two or more races, and Latino) made up only 12% of the profession. Building community in the form of cohorts is a vital opportunity that allows librarians of color to connect with one another and provide support while navigating a profession that is predominantly white.

In this presentation, the panelists will discuss different types of cohorts that exist in POC in LIS circles. We conclude by presenting a call to action and ask participants how they might define a cohort, …


Urban Forests And Their Potential To Combat Food Insecurity: Analyzing Foods From Street Trees In New York City, Ny, Kristen Cooney Jul 2021

Urban Forests And Their Potential To Combat Food Insecurity: Analyzing Foods From Street Trees In New York City, Ny, Kristen Cooney

Environment and Sustainability Summer Fellows

There is growing recognition that urban forests have the potential to combat food insecurity via their edible parts, namely fruits, berries, and nuts. Many tree species commonly planted in urban spaces have edible parts that may fulfill the nutritional needs of city residents that are food insecure, but no one has analyzed the value of city street trees to understand this potential. I analyzed New York City’s street trees by each species and their edible parts to measure this potential.


Disease, Development, And Disorder: Examining The Effect Of Health On Subnational Development And Conflict In Sub-Saharan Africa, Dlorah C. Jenkins Jul 2021

Disease, Development, And Disorder: Examining The Effect Of Health On Subnational Development And Conflict In Sub-Saharan Africa, Dlorah C. Jenkins

Doctor of International Conflict Management Dissertations

Progress towards achieving the Sustainable Development Goals (SDGs) has been uneven across and within countries - particularly in Africa, least developed countries, and low-income countries. The COVID-19 pandemic has threatened to reverse much of the progress made towards achieving the SDGs, especially SDG 3, which aims to “ensure healthy lives and promote well-being for all at all ages”.

The tendency for disease, underdevelopment, and conflict to occur concomitantly suggests potential causal mechanisms linking them. This study attempts to address two pieces of the puzzle: the causal effect of disease on underdevelopment and the impact of development on conflict risk. Focusing …


Diagnosis Of Classic Homocystinuria In Two Boys Presenting With Acute Cerebral Venous Thrombosis And Neurologic Dysfunction After Normal Newborn Screening, Alexander Asamoah, Sainan Wei, Kelly E. Jackson, Joseph H. Hersh, Harvey Levy Jul 2021

Diagnosis Of Classic Homocystinuria In Two Boys Presenting With Acute Cerebral Venous Thrombosis And Neurologic Dysfunction After Normal Newborn Screening, Alexander Asamoah, Sainan Wei, Kelly E. Jackson, Joseph H. Hersh, Harvey Levy

Pathology and Laboratory Medicine Faculty Publications

Homocystinuria, caused by cystathionine β-synthase deficiency, is a rare inherited disorder involving metabolism of methionine. Impaired synthesis of cystathionine leads to accumulation of homocysteine that affects several organ systems leading to abnormalities in the skeletal, cardiovascular, ophthalmic and central nervous systems. We report a 14-month-old and a 7-year-old boy who presented with neurologic dysfunction and were found to have cerebral venous sinus thromboses on brain magnetic resonance imaging (MRI)/magnetic resonance venogram (MRV) and metabolic and hypercoagulable work-up were consistent with classic homocystinuria. The 14-month-old boy had normal newborn screening. The 7-year-old boy initially had an abnormal newborn screen for homocystinuria …