Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2021

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 2071 - 2100 of 10798

Full-Text Articles in Entire DC Network

An Exploration Of Covid-19 And Dietary Patterns In Collegiate Athletes, Megan Hammel Oct 2021

An Exploration Of Covid-19 And Dietary Patterns In Collegiate Athletes, Megan Hammel

Research Papers

PURPOSE: The purpose of this research study is to determine how colligate athlete’s nutritional status and eating habits changed during the COVID-19 home confinement period in spring 2020.

METHODOLODY: Southern Illinois University Carbondale athletes (n=52) completed a modified Renzo, L. D., et al, 2020 questionnaire on SurveyMonkey. Participants were asked questions regarding their personal data, dietary habits, and lifestyle habits related to before and during the spring 2020 COVID-19 home confinement period. The data was analyzed through SurveyMonkey and described utilizing a quantitative and qualitative approach.

RESULTS: A total of 52 participants took part in the research study. All 52 …


Using The 4-H Essential Elements To Evaluate Teen Programming, Joy Lile, Elizabeth Weybright, Pam Watson Oct 2021

Using The 4-H Essential Elements To Evaluate Teen Programming, Joy Lile, Elizabeth Weybright, Pam Watson

Journal of Youth Development

National and state trends indicate participation in 4-H programming declines throughout adolescence. Past research suggests factors that may influence recruitment and retention of teens into youth development programming. Washington State University undertook an evaluation to understand the needs and desires of teens in the 4-H program and make recommendations for improvements to recruitment and retention of teens in 4-H. The study sample was made up of 93 young people aged 12 to 19 years who participated in the online survey. Results included youth demographics, participation styles, communication preferences, youth outcomes, and feedback about program benefits and opportunities for growth. The …


Implementation Of Anyaka Makwiri: A Multicomponent Mentoring Program For Adolescent Girls And Young Women In Uganda, Kate Plourde, Geeta Nanda, Elise Healy, Dennis Kibwola Oct 2021

Implementation Of Anyaka Makwiri: A Multicomponent Mentoring Program For Adolescent Girls And Young Women In Uganda, Kate Plourde, Geeta Nanda, Elise Healy, Dennis Kibwola

Journal of Youth Development

This article describes the development and implementation of the Anyaka Makwiri program and summarizes results from the qualitative assessment of participant experiences. Anyaka Makwiri is a multicomponent mentoring program developed for adolescent girls and young women (AGYW) ages 15 to 24 in Gulu, Uganda. The comprehensive program consisted of a curriculum covering sexual and reproductive health (SRH), financial capabilities, soft skills, and gender-based violence and gender equality; activities designed to improve participants’ social connectedness; optional onsite testing for sexually transmitted infections (STIs), HIV, and pregnancy along with STI treatment; group-based savings; and links to SRH services, including contraceptive and gender-based …


Positive Youth Development In Senegal: A Case Study Of 4-H Senegal, Thomas Archibald, Bineta Guisse, Amadou Ndiaye, Fatimata Kane Oct 2021

Positive Youth Development In Senegal: A Case Study Of 4-H Senegal, Thomas Archibald, Bineta Guisse, Amadou Ndiaye, Fatimata Kane

Journal of Youth Development

African youth face great challenges and great opportunities. Positive youth development (PYD) programs have the potential to support youth in Africa to reach their full potential. Yet PYD approaches must be tailored if they are to be contextually and culturally responsive and relevant. The purpose of this paper is to provide an evidence-informed description of one such program, the 4-H Senegal PYD program. We first provide a conceptual background for the program, informed especially by the literature on global and cross-cultural PYD. We then share empirical results of a qualitative case study focused on the establishment, scale-up, and institutionalization of …


With Due Respect For Humanity: Engaging Affectivity Through Simulation In Catholic Seminary Formation, Marie Diane Pitt-Payne Oct 2021

With Due Respect For Humanity: Engaging Affectivity Through Simulation In Catholic Seminary Formation, Marie Diane Pitt-Payne

Dissertations (1934 -)

Since 1992, Catholic seminaries have approached the education of future priests through a lens of four areas of formation: intellectual, human, pastoral, and spiritual. Although human formation is considered foundational in the formation process, it has not been effectively integrated into seminary curriculum. The language of integral personalism was introduced into the formation landscape by Pope John Paul II, but this anthropology has not sufficiently informed seminary pedagogy. There is a still a subordination of the affective sphere in seminaries, particularly in intellectual formation. Medical schools have developed a pedagogical method that inserts real emotion into the educational process. This …


Intimate Partner Violence And Parenting: A Qualitative Study With Immigrant Latinas, Karina Tobon Loyo Oct 2021

Intimate Partner Violence And Parenting: A Qualitative Study With Immigrant Latinas, Karina Tobon Loyo

Dissertations (1934 -)

Intimate partner violence (IPV) is widespread among women, including those that are mothers (Austin et al., 2017). The impact of experiencing IPV is considered a significant health problem for women and their children (Amerson et al., 2014). The deleterious effects of IPV on parenting have been documented, including less effective parenting, engagement, communication and greater harsh discipline and neglect (Chiesa et al., 2018). Despite being the second fastestgrowing ethnoracial group, IPV research on Latinas specifically has been sparse and represents a critical public health concern that requires empirical attention (Paat et al., 2017). Immigrant Latinas may be particularly vulnerable due …


Development And Implementation Of An Enhanced Recovery After Surgery Protocol For Thoracic Surgery Procedures, Nicholas Collier Oct 2021

Development And Implementation Of An Enhanced Recovery After Surgery Protocol For Thoracic Surgery Procedures, Nicholas Collier

Doctor of Nursing Practice Projects

A high prevalence of lung and esophageal cancers leads to significant healthcare dollars utilized for treatment and management. Surgical resection is regarded as a key component for multidisciplinary treatment and management of these cancers. By standardizing multidisciplinary patient care and utilizing evidence-based practice, Enhanced Recovery After Surgery (ERAS) protocols for thoracic surgery have offered better outcomes with fewer complications and reduced healthcare costs. The anesthesia providers at the host facility were deficient in basic knowledge related to ERAS protocols and best practice management of thoracic surgery patients. The purpose of this project was to educate anesthesia providers on ERAS principles …


2021 Fall Newsletter, Morehead State University. Nursing Department. Oct 2021

2021 Fall Newsletter, Morehead State University. Nursing Department.

Nursing Department Publications Archive

2021 Fall Newsletter of the Department of Nursing at Morehead State University.


Chairs Of Excellence Annual Report 2021, Tennessee. Higher Education Commission. Oct 2021

Chairs Of Excellence Annual Report 2021, Tennessee. Higher Education Commission.

Academic Programs and Workforce Reports

No abstract provided.


Rorα Suppresses Cancer-Associated Inflammation By Repressing Respiratory Complex I-Dependent Ros Generation, Wei Mao, Gaofeng Xiong, Yuanyuan Wu, Chi Wang, Daret St. Clair, Jai-Da Li, Ren Xu Oct 2021

Rorα Suppresses Cancer-Associated Inflammation By Repressing Respiratory Complex I-Dependent Ros Generation, Wei Mao, Gaofeng Xiong, Yuanyuan Wu, Chi Wang, Daret St. Clair, Jai-Da Li, Ren Xu

Markey Cancer Center Faculty Publications

Breast cancer development is associated with macrophage infiltration and differentiation in the tumor microenvironment. Our previous study highlights the crucial function of reactive oxygen species (ROS) in enhancing macrophage infiltration during the disruption of mammary tissue polarity. However, the regulation of ROS and ROS-associated macrophage infiltration in breast cancer has not been fully determined. Previous studies identified retinoid orphan nuclear receptor alpha (RORα) as a potential tumor suppressor in human breast cancer. In the present study, we showed that retinoid orphan nuclear receptor alpha (RORα) significantly decreased ROS levels and inhibited ROS-mediated cytokine expression in breast cancer cells. RORα expression …


Student’S Perspectives Of Chronic Absenteeism In A Suburban High School, Herbert Allen Gray Oct 2021

Student’S Perspectives Of Chronic Absenteeism In A Suburban High School, Herbert Allen Gray

Theses and Dissertations

For many students, school attendance is a critical issue. There have been several studies conducted concerning attendance numbers. These studies have shown that poor attendance often affects grades, graduation rates, and socioeconomic status post-high school. The purpose of this study was to first investigate the reasons behind absences and attitudes towards school and classes because of missed days. The second purpose was to determine if a weekly mentoring meeting had any noticeable effect on attendance. The targeted pool of students consisted of those who had been identified as chronically absent the previous semester. An initial set of open-ended questions and …


Racial Disparities In Gestational Weight Gain, Body Mass Index, And Physical Activity During Pregnancy And After Delivery, Marcey Acacia Jiles Oct 2021

Racial Disparities In Gestational Weight Gain, Body Mass Index, And Physical Activity During Pregnancy And After Delivery, Marcey Acacia Jiles

Theses and Dissertations

Background & Purpose: African American women have higher rates of obesity than white women. Pregnancy is characterized by rapid weight gain, and 48.8% of women in South Carolina exceed recommended limits. Prenatal exercise is recommended and may help prevent excessive gestational weight gain (GWG). Our purpose was to determine whether GWG and prenatal exercise levels differed between African American and Caucasian women.

Methods: We included 79 women who delivered a singleton infant 6 months - 3 years ago and were free from smoking, type 1 or 2 diabetes, or use of steroids or protease inhibitors (mean age =31.3 yrs; mean …


Assessing Early Use And Complications Of Gastrostomy Blended Feeds., James Fraser, Kristen L. Sayers, Amy L. Pierce, Beth A. Orrick, Wendy Jo Svetanoff, Tolulope A. Oyetunji Md Mph, Shawn D. St Peter Oct 2021

Assessing Early Use And Complications Of Gastrostomy Blended Feeds., James Fraser, Kristen L. Sayers, Amy L. Pierce, Beth A. Orrick, Wendy Jo Svetanoff, Tolulope A. Oyetunji Md Mph, Shawn D. St Peter

Posters

Providers are hesitant to recommend using blended tube feeds (BF) after gastrostomy tube (GT) placement due to increased risk of bacterial contamination, nutrition inadequacy, tube blockages, and lack of data addressing clinical outcomes. Caregivers often feel that BF are more natural, better tolerated, and more cost-effective. We studied early use of BF, potential complications, and satisfaction among caregivers.


Adaptation Of An Artificial Bait To An Automated Aerial Delivery System For Landscape-Scale Brown Treesnake Suppression, Rafael A. Garcia, Thomas W. Mcauliffe, Lorelie P. Bumanlag, Shane R. Siers, Bruce A. Kimball Oct 2021

Adaptation Of An Artificial Bait To An Automated Aerial Delivery System For Landscape-Scale Brown Treesnake Suppression, Rafael A. Garcia, Thomas W. Mcauliffe, Lorelie P. Bumanlag, Shane R. Siers, Bruce A. Kimball

United States Department of Agriculture Wildlife Services: Staff Publications

Dead neonatal mice are currently used as bait for delivery of toxin to invasive brown treesnakes (Boiga irregularis) on Guam; once deployed in the field the mice are highly attractive to the snakes but only for about four days. An artificial bait containing a mixture of fats mimicking those in skin of the mice is also highly attractive to the snakes and remains attractive 2–3 times longer. The artificial bait, however, costs more than the mice, and is more difficult to attach to the capsules of a novel aerial bait delivery system. This paper describes a reformulation of the bait …


Threading The Needle: How Humans Influence Predator–Prey Spatiotemporal Interactions In A Multiple-Predator System, Asia Murphy, Duane R. Diefenbach, Mark Ternent, Matt Lovallo, David Miller Oct 2021

Threading The Needle: How Humans Influence Predator–Prey Spatiotemporal Interactions In A Multiple-Predator System, Asia Murphy, Duane R. Diefenbach, Mark Ternent, Matt Lovallo, David Miller

United States Department of Agriculture Wildlife Services: Staff Publications

Perceived predation risk and the resulting antipredator behaviour varies across space, time and predator identity. Communities with multiple predators that interact and differ in their use of space, time of activity and hunting mode create a complex landscape for prey to avoid predation. Anthropogenic presence and disturbance have the potential to shift interactions among predators and prey and the where and when encounters occur. We examined how white-tailed deer Odocoileus virginianus fawn spatiotemporal antipredator behaviour differed along an anthropogenic disturbance gradient that had black bears Ursus americanus, coyotes Canis latrans, bobcats Lynx rufus and humans present. We quantified (a) spatial …


A Study On Constructing The Fourth Financial Statement For The Performance Prediction And Value Assessment Of Internet Enterprises In The Food Industry, Jianxin Zhang Oct 2021

A Study On Constructing The Fourth Financial Statement For The Performance Prediction And Value Assessment Of Internet Enterprises In The Food Industry, Jianxin Zhang

Dissertations and Theses Collection (Open Access)

For a long time, industry, financial institutions, PE investment funds, and capital market investors have determined the business performance and market value of a company, usually based on the data of the three audited financial tables provided by the company, and further comprehensive analysis will be carried out the evaluation. Due to the limitations of accounting standards, the three financial tables cannot truly reflect all the business conditions of the enterprise. At the same time, the economic stage with traditional manufacturing as the main body and the economic stage with the digital economy as the main body are concerned with …


Pharmaceutical Potential Of Laboratory Grown Cultures Of Blue-Green Algae: A Comprehensive Review And Future Possibilities, Ritu Chauhan, Abhishek Chauhan, Ashutosh Tripathi, Anuj Ranjan, Subhash C. Chauhan, Tanu Jindal Oct 2021

Pharmaceutical Potential Of Laboratory Grown Cultures Of Blue-Green Algae: A Comprehensive Review And Future Possibilities, Ritu Chauhan, Abhishek Chauhan, Ashutosh Tripathi, Anuj Ranjan, Subhash C. Chauhan, Tanu Jindal

School of Medicine Publications

COVID-19 pandemic has taught the world researchers the urgent need for new sources and novel pharmaceuticals not only for existing diseases but also for both seasonal epidemics and future pandemics. Pharmaceutical drug discoveries for the past fifty years depended deeply on the procedure of empirical transmission of a huge number of pure bioactive compounds to provide new leads. The screening of extracts or isolating compounds is a common way to discover novel biologically active molecules. Most of the valuable Blue-Green algal metabolites are concentrated in their biomass. For existence in nature, Blue-Green algae (BGA) secrete and contain various organic substances …


Severe Hypertriglyceridemia: Care For The Non-Diabetic Patient, Children's Mercy Kansas City Oct 2021

Severe Hypertriglyceridemia: Care For The Non-Diabetic Patient, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Care Process Models)

No abstract provided.


Plastic-Eating Microbes: A New Potential Solution To Waste Mitigation?, Megan Forbes Oct 2021

Plastic-Eating Microbes: A New Potential Solution To Waste Mitigation?, Megan Forbes

University Honors Theses

Plastic waste is problematic for marine and terrestrial ecosystems due to the mass production of polyethylene terephthalate (PET) single use plastics. What is unclear is a well-thought-out solution to solve pollution problems that will not further damage the environment. Throughout this literature review, I will investigate the role microbes play in plastic degradation, and if plastic eating microbes are an effective solution to the plastic pollution problem. Polyethylene terephthalate (PET) is the chemical name for polyester. It is a clear, strong, and lightweight plastic that is typically used for food and beverage packaging, and other single-use purposes. The most well …


Medicaid Waivers, Administrative Authority, And The Shadow Of Malingering, Nicole Huberfeld Oct 2021

Medicaid Waivers, Administrative Authority, And The Shadow Of Malingering, Nicole Huberfeld

Faculty Scholarship

From 2018 through 2020, HHS approved state Medicaid demonstration waivers to impose new eligibility conditions such as work requirements, connecting current “personal responsibility” rhetoric and historical suspicion of malingering. The Biden administration reversed course but advocated to the Supreme Court for expansive administrative discretion. This approach supports health equity now but could enable reemergence of restrictive health policies down the road.


Socio-Technical Changes For Sustainable Rice Production: Rice Husk Amendment, Conservation Irrigation, And System Changes, Benjamin R. K. Runkle, Angelia L. Seyfferth, Matthew C. Reid, Matthew A. Limmer, Beatriz Moreno-Garcia, Colby W. Reavis, Jasquelin Pena, Michele L. Reba, M. Arlene A. Adviento-Borbe, Shannon R. M. Pinson, Chris Isbell Oct 2021

Socio-Technical Changes For Sustainable Rice Production: Rice Husk Amendment, Conservation Irrigation, And System Changes, Benjamin R. K. Runkle, Angelia L. Seyfferth, Matthew C. Reid, Matthew A. Limmer, Beatriz Moreno-Garcia, Colby W. Reavis, Jasquelin Pena, Michele L. Reba, M. Arlene A. Adviento-Borbe, Shannon R. M. Pinson, Chris Isbell

Biological and Agricultural Engineering Faculty Publications and Presentations

Rice is a staple food and primary source of calories for much of the world. However, rice can be a dietary source of toxic metal(loid)s to humans, and its cultivation creates atmospheric greenhouse gas emissions and requires high water use. Because rice production consumes a significant amount of natural resources and is a large part of the global agricultural economy, increasing its sustainability could have substantial societal benefits. There are opportunities for more sustainable field production through a combination of silicon (Si) management and conservation irrigation practices. As a Si-rich soil amendment, rice husks can limit arsenic and cadmium uptake, …


Climate Reparations: Moral, Historical, And Legal Justifications For United States Reparations Payments To Female Population Groups In Developing Countries, Kate Belsito Oct 2021

Climate Reparations: Moral, Historical, And Legal Justifications For United States Reparations Payments To Female Population Groups In Developing Countries, Kate Belsito

Cardozo International & Comparative Law Review

The note advocates for a community-based reparations program targeting women in rural, developing countries most affected by climate change. It asserts that the United States, as a major historical emitter of greenhouse gases, bears significant responsibility for these harms and has failed to meet its international treaty obligations. The proposed program would address past injustices while promoting future adaptation, emphasizing moral accountability and systemic change.


Activation Of The Innate Immune System In Children With Irritable Bowel Syndrome Evidenced By Increased Fecal Human Β-Defensin-2, Robert J Shulman, Sridevi Devaraj, Margaret Heitkemper Oct 2021

Activation Of The Innate Immune System In Children With Irritable Bowel Syndrome Evidenced By Increased Fecal Human Β-Defensin-2, Robert J Shulman, Sridevi Devaraj, Margaret Heitkemper

Children’s Nutrition Research Center Staff Publications

Background & aims: The role of the innate immune system in functional gastrointestinal pain disorders is unclear. We investigated the role of β-defensin-2 and gut permeability in childhood irritable bowel syndrome (IBS) and functional abdominal pain (FAP) symptom generation.

Methods: Fecal β-defensin-2 (and in a subset, gut permeability) was measured in children with IBS (n = 116), FAP (n = 33), and healthy control (HC) children (n = 72). IBS and FAP patients were recruited from tertiary and primary care, and HCs were recruited from primary care.

Results: β-defensin-2 concentration was greater in children with IBS (P = .003) and …


Development Of Food Pattern Recommendations For Infants And Toddlers 6-24 Months Of Age To Support The Dietary Guidelines For Americans, 2020-2025, Kathryn G Dewey, Tusarebecca Pannucci, Kellie O Casavale, Teresa A Davis, Sharon M Donovan, Ronald E Kleinman, Elsie M Taveras, Regan L Bailey, Rachel Novotny, Barbara O Schneeman, Jamie Stang, Janet De Jesus, Eve E Stoody Oct 2021

Development Of Food Pattern Recommendations For Infants And Toddlers 6-24 Months Of Age To Support The Dietary Guidelines For Americans, 2020-2025, Kathryn G Dewey, Tusarebecca Pannucci, Kellie O Casavale, Teresa A Davis, Sharon M Donovan, Ronald E Kleinman, Elsie M Taveras, Regan L Bailey, Rachel Novotny, Barbara O Schneeman, Jamie Stang, Janet De Jesus, Eve E Stoody

Children’s Nutrition Research Center Staff Publications

Background: Developing food-based dietary guidelines (FBDGs) for infants and toddlers is a complex task that few countries have attempted.

Objectives: Our objectives are to describe the process of food pattern modeling (FPM) conducted to develop FBDGs for the Dietary Guidelines for Americans, 2020-2025 for infants 6 to <12 mo and toddlers 12 to <24 mo of age, as well as the implications of the results and areas needing further work.

Methods: The US 2020 Dietary Guidelines Advisory Committee, with the support of federal staff, conducted FPM analyses using 5 steps: 1) identified energy intake targets; 2) established nutritional goals; 3) identified food groupings and expected amounts, using 3 options for the amount of energy from human milk in each age interval; 4) estimated …


Aixfood'21: 3rd Workshop On Aixfood, Ricardo Guerrero, Michael Spranger, Shuqiang Jiang, Chong-Wah Ngo Oct 2021

Aixfood'21: 3rd Workshop On Aixfood, Ricardo Guerrero, Michael Spranger, Shuqiang Jiang, Chong-Wah Ngo

Research Collection School Of Computing and Information Systems

Food and cooking analysis present exciting research and application challenges for modern AI systems, particularly in the context of multimodal data such as images or video. A meal that appears in a food image is a product of a complex progression of cooking stages, often described in the accompanying textual recipe form. In the cooking process, individual ingredients change their physical properties, become combined with other food components, all to produce a final, yet highly variable, appearance of the meal. Recognizing food items or meals on a plate from images or videos, their physical properties such as the amount, nutritional …


Latent Class Analysis For Identifying Subclasses Of Depression Using Jmp Pro 16, Karishma Yadav, Fei Fei Sue-Ann Seet, Tin Seong Kam, Tin Seong Kam Oct 2021

Latent Class Analysis For Identifying Subclasses Of Depression Using Jmp Pro 16, Karishma Yadav, Fei Fei Sue-Ann Seet, Tin Seong Kam, Tin Seong Kam

Research Collection School Of Computing and Information Systems

According to WHO, “Depression is a leading cause of disability worldwide and is a major contributor to the overall global burden of disease”. A major stumbling block in the care of depressed patients remains the accurate diagnosis of the severity of depression. Patient Health Questionnaire (PHQ-9), a 9-question instrument is widely used for diagnosing and determining the severity of depression. However, the popularly used 5-Category of depression severity based on the sum of responses to the 9 questions was overly subjective. In view of this limitation, our paper aims to demonstrate how Latent Class Analysis of JMP Pro can be …


Alterations To The Brain Following Traumatic Brain Injury, Jacqueline Mader Oct 2021

Alterations To The Brain Following Traumatic Brain Injury, Jacqueline Mader

Honors Projects

Traumatic brain injuries (TBIs) have been labeled as a modern-day epidemic, increasing exponentially with the advancement of technology and society. Gaining a better understanding of the cognitive paths, including the chemical and electrical signals of the brain, neural correlates, and possible interventions for TBI patients allows for the best possible outcome for every patient, and allows for the further advancement of care. By revising and reassessing the ways in which TBIs are categorized and described the prognosis for recovery paints a more realistic view for each individual patient case. The symptoms and impairments that may occur post-injury can be monitored …


The Holistic Self-Care Learning Experience Of Rn-To-Bsn Students: A Phenomenological Study Of Meaning And Value, Elaina C. Mahlan Oct 2021

The Holistic Self-Care Learning Experience Of Rn-To-Bsn Students: A Phenomenological Study Of Meaning And Value, Elaina C. Mahlan

Doctor of Education (Ed.D)

The health of the nursing workforce is a critical aspect of high-quality health care and community health promotion, but extensive research indicates that too many nurses neglect selfcare and suffer negative health outcomes. While nursing education must provide self-care learning experiences to improve the health of nurses, the value and influence of a learning experience must be interpreted from the learner’s point of view. The purpose of this phenomenological study was to elicit the personal value that RN-to-BSN students ascribed to a self-care learning experience within a holistic nursing course at a public university. The holistic nursing paradigm offers a …


Model Systems To Study The Chronic, Polymicrobial Infections In Cystic Fibrosis: Current Approaches And Exploring Future Directions, George A. O’Toole, Aurélie Crabbé, Rolf Kümmerli, John J. Lipuma, Jennifer M. Bomberger, Jane C. Davies, Dominique Limoli, Vanessa V. Phelan, James B. Bliska, William H. Depas, Lars E. Dietrich, Thomas H. Hampton, Ryan Hunter, Cezar M. Khursigara, Alexa Price-Whelan, Alix Ashare, Robert A. Cramer, Joanna B. Goldberg, Freya Harrison, Deborah A. Hogan Oct 2021

Model Systems To Study The Chronic, Polymicrobial Infections In Cystic Fibrosis: Current Approaches And Exploring Future Directions, George A. O’Toole, Aurélie Crabbé, Rolf Kümmerli, John J. Lipuma, Jennifer M. Bomberger, Jane C. Davies, Dominique Limoli, Vanessa V. Phelan, James B. Bliska, William H. Depas, Lars E. Dietrich, Thomas H. Hampton, Ryan Hunter, Cezar M. Khursigara, Alexa Price-Whelan, Alix Ashare, Robert A. Cramer, Joanna B. Goldberg, Freya Harrison, Deborah A. Hogan

Dartmouth Scholarship

A recent workshop titled “Developing Models to Study Polymicrobial Infections,” sponsored by the Dartmouth Cystic Fibrosis Center (DartCF), explored the development of new models to study the polymicrobial infections associated with the airways of persons with cystic fibrosis (CF). The workshop gathered 351 investigators over two virtual sessions. Here, we present the findings of this workshop, summarize some of the challenges involved with developing such models, and suggest three frameworks to tackle this complex problem. The frameworks proposed here, we believe, could be generally useful in developing new model systems for other infectious diseases. Developing and validating new approaches to …


Hindlimb Suspension In Wistar Rats: Sex-Based Differences In Muscle Response, Marie Mortreux, Megan E. Rosa-Caldwell, Ian D. Stiehl, Dong Min Sung, Nicholas T. Thomas, Christopher S. Fry, Seward B. Rutkove Oct 2021

Hindlimb Suspension In Wistar Rats: Sex-Based Differences In Muscle Response, Marie Mortreux, Megan E. Rosa-Caldwell, Ian D. Stiehl, Dong Min Sung, Nicholas T. Thomas, Christopher S. Fry, Seward B. Rutkove

Dartmouth Scholarship

Ground-based animal models have been used extensively to understand the effects of microgravity on various physiological systems. Among them, hindlimb suspension (HLS), developed in 1979 in rats, remains the gold-standard and allows researchers to study the consequences of total unloading of the hind limbs while inducing a cephalic fluid shift. While this model has already brought valuable insights to space biology, few studies have directly compared functional decrements in the muscles of males and females during HLS. We exposed 28 adult Wistar rats (14 males and 14 females) to 14 days of HLS or normal loading (NL) to better assess …