Digital Commons Network^™

Using Characters To Narrow Culture Gaps, Xiangyu Han

Theses

There are a lot of different cultures around the world. It is hard for people with various cultural backgrounds to understand each other. Language is the most direct expression of cultural barriers. With the different structures of languages, communication becomes unsmooth. People can get to know each other better if we narrow down the gaps. The research here discusses the possibility of building a connection between language characters through the graphic. This work will use Chinese and English as an experimental. Images and pictures are the most visual information for people to read. And languages are the most direct information …

On The Bookshelf, Susan Dumais

UNH Today Archive

No abstract provided.

Panel With Governor Chris Christie And The Honorable Judge Paul Matey, Seton Hall Legislative Journal Sports Law Symposium

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

Money Laundering And The Art Market: Closing The Regulatory Gap, Adriana M. Baranello

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

License To Heal: Understanding A Healthcare Platform Organization As A Multi-Level Surveillant Assemblage, Handan Vicdan, Mar Pérezts, Asım Fuat Fırat

Management Faculty Publications

Platform organizations bring renewed attention to power disparities and risks in the rise of surveillance capitalism. However; such critical accounts provide a partial understanding of the complexity of surveillance phenomena in such shifting socio-technical and digital environments.The findings from a netnographic investigation of a healthcare platform organization, PatientsLikeMe, unravel how platforms become the locus where multi-level flows of surveillance converge, thereby constituting what we identify as a surveillant assemblage. We develop a comprehensive approach for understanding how platforms constitute a dynamic crossroads of micro-, meso- and macro-surveillance phenomena within and beyond the online communities they create.This study highlights this surveillant …

Characterization Of Bacteriophage Targeting Bacillus Licheniformis In Milk Processes And Thermal Stability Of Bacteriophage During Htst Pasteurization, Jeremy Robert Arbon

Theses and Dissertations

An array of Bacillus licheniformis strains were isolated from a commercial powdered milk process. Bacteriophages exhibiting activity against B. licheniformis were isolated from cattle manure and effluent samples destined for a lagoon at a dairy farm. After sequencing, 8 of the 10 phages were found to be novel and genetically differentiated. Transmission electron scanning microscopy (TSEM) was performed. All bacteriophages were of the family Herelleviridae with contractile tail sheaths ranging from 80µm to 150µm and, surprisingly, survived a common fluid milk processing treatment used to inactivate vegetative cells. The survival of the phage after high temperature short time pasteurization of …

Political-Pedagogical Character Of The Collective Actions Of The Popular Bars, Magda Victoria Díaz Alzate Sra, Juan Pablo Menjura Acosta Sr, Maria Clara Fonseca Echeverri Sra

The Qualitative Report

Barrismo is a complex phenomenon and cannot be defined universally. Social representation is based on deficient conceptions that relate it to the use of psychoactive substances and violence. This article presents qualitative research evidence based on the epistemological assumptions of social constructionism, a hermeneutical phenomenological design and the use of qualitative interview and documentary and audiovisual review, to understand the political-pedagogical character of the collective actions of the popular bars of the city of Medellín, Colombia, as practices that contribute to the transformation of the territories. Categories found: i. Bars as popular movements: transition from the brave bar to the …

Utility Of Facebook's Social Connectedness Index In Modeling Covid-19 Spread: Exponential Random Graph Modeling Study, Beth Prusaczyk, Kathryn Pietka, Joshua M Landman, Douglas A Luke

Open Access Publications

BACKGROUND: The COVID-19 (the disease caused by the SARS-CoV-2 virus) pandemic has underscored the need for additional data, tools, and methods that can be used to combat emerging and existing public health concerns. Since March 2020, there has been substantial interest in using social media data to both understand and intervene in the pandemic. Researchers from many disciplines have recently found a relationship between COVID-19 and a new data set from Facebook called the Social Connectedness Index (SCI).

OBJECTIVE: Building off this work, we seek to use the SCI to examine how social similarity of Missouri counties could explain similarities …

Working Paper No. 53, Mexico Under Neoliberalism, Daniela M. Ávila Arévalo

Working Papers in Economics

This inquiry seeks to establish that a set of policies that can be identified as ‘neoliberalism’ has generated observable effects on the economy and society of Mexico. Initiated during the last decades of the twentieth century, a combination of external and internal interests led to the implementation of neoliberal policies. The marketization of Mexico’s economy during the 1980s and 90s consolidated ‘structural adjustments.’ Through extensive privatization of what were statist assets, combined with the deregulation of trade as well as numerous aspects of private sector activity, the Mexican economy came to rely upon a low-wage labor export-model that also undermined …

Development And Application Of A Novel Acoustic Microfluidic Technology For Single Cell Per Well Trapping And High-Resolution Analysis Of Cilia Motion In Chlamydomonas Reinhardtii, Mingyang Cui

McKelvey School of Engineering Graduate Student Theses & Dissertations

Acoustic manipulation of cells and microorganisms is a label-free and contact-free technique with promise for biological and biomedical applications. When exposed to an ultrasonic standing wave field, particles suspended in microfluidic channels will be moved to pressure minima (nodes) or maxima (antinodes) due to the acoustic impedance mismatch between particles and the suspension medium. Cilia motion is fundamental to understanding biological and biomedical problems related to dysfunctional human cilia, including primary ciliary dyskinesia, blindness, and male infertility. However, in vivo and ex vivo mammalian ciliated cell research is laborious and time-consuming due to difficulty in growing, maintaining, and imaging these …

Identifying Structures For Ion Channel Kinetic Models, Kathryn Mangold

McKelvey School of Engineering Graduate Student Theses & Dissertations

Voltage-gated ion channels carry transmembrane current and underlie the voltages changes seen during the action potential. The ion channels open and close precisely, or gate, in response to voltage to create the specific cellular action potential waveform. The first models of voltage-gated ion channels gating dynamics were described by Hodgkin and Huxley when studying the neuronal action potential in the squid giant axon. While the probabilistic gating variables cleverly imagined by Hodgkin and Huxley to describe channel gating are still used today to describe cardiac ionic currents, Markov (or state-dependent) models provide a more accurate representation of channel dynamics. As …

Zebrafish Models Of Katp Channelopathies, Soma S. Singareddy

McKelvey School of Engineering Graduate Student Theses & Dissertations

Much work has been carried out to understand the composition, structure, and function of ATP-sensitive potassium (KATP) channels in mammalian tissues, as well as the molecular basis of the channelopathies that result from loss-of-function or gain-of-function mutations in these channels. These studies have also highlighted that the available pharmacology to treat such diseases is limited. To overcome such limitations, a better understanding of the tissue specificity of expression, the exact mechanisms linking the molecular dysfunction to the development of complex pathophysiology, the potential for reducing cross-reactivity of drugs, and ultimately more specific therapies are needed. The work described in this …

Laser Stimulated Dynamic Thermal Imaging System For Tumor Detection, Hongyu Meng

McKelvey School of Engineering Graduate Student Theses & Dissertations

Laser stimulated dynamic thermal imaging system for tumor detectionby Hongyu Meng Doctor of Philosophy in Biomedical Engineering Washington University in St. Louis, 2021 Professor Samuel Achilefu, Chair Recent advances in infrared sensor technology have enabled the rapid application of thermal imaging in materials science, security and medicine. Relying on the infrared characteristics of living systems, thermal imaging has been used to generate individual heat maps, detect inflammation and tumor. As an imaging system, thermal imaging has the advantages of portability, real-time, non-invasive, and non-contact. But the low specificity of thermal imaging hinders its wide clinical application.

Unfortunately, label-free DTI is …

Interfacial Engineering And Photoelectrochemistry Of Patterned Metal/Semiconductor Heterostructures, Che Tan

McKelvey School of Engineering Graduate Student Theses & Dissertations

Photoelectrochemical (PEC) cells enable the conversion of solar energy into storable fuels, which is critical in overcoming the intermittent nature of this largest renewable source. However, the majority of semiconductors used as photoelectrodes in these cells have low conversion efficiencies and/or stabilities. Silicon (Si) is an attractive semiconductor material for photoelectrodes, but the development of efficient Si-based photoanodes is challenging due to their instability in alkaline solutions. Thus, one focus of this dissertation is the design and fabrication of highly stable nickel (Ni)-patterned Si photoanodes through interfacial engineering of the barrier heights. Recently, hot carriers in plasmonic metal nanostructures have …

Anion Exchange Membranes In Electrochemical Energy Systems, Yunzhu Zhang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Non-CO2-emitting sources of renewable energy, such as solar and wind, have become quite popular in recent years, and their electricity generation cost at scale has become comparable with that of gas- and coal-fired power plants. However, their intermittent output makes the resultant electricity hard to dispatch in a reliable manner in the absence of grid-scale electrical energy storage (EES) technologies. Redox-flow batteries (RFBs) are promising devices for medium- to large-scale electric energy storage. They are safe, reliable, and portable, and are designed with decoupled power and energy modules, which makes it easy and cost-effective to scale their output to meet …

Rethinking The Rhetorical Dimensions Of Public Refusals, Tyler Stafford

Electronic Theses and Dissertations Archive

In this dissertation on rethinking the rhetorical dimensions of public refusals, I attempt to enhance the heuristic value of compositionist John Schilb’s neglected but promising concept of rhetorical refusal with (1) an amplification of his higher principle criterion using rhetorical studies of decorum and (2) the scholarly deployment of strategic silence, journalism ethics, controversy and melodrama, irony, and prophetic rhetoric. In so doing, I (1) endeavor to inspire cross-disciplinary dialogue between those who study rhetoric in communication departments and those who study rhetoric in English departments; (2) demonstrate analyses of rhetorical refusals that take us beyond the cases explored in …

“Deployment Of Data Analytics To Support Manufacturing At Janssen”, Patrick T. O'Sullivan, Marcus O'Mahony

Level 3

This paper describes two key areas of value that data analytics supported for Janssen: yield optimisation and Tech. Transfer. By focusing on two key business areas the definition of success and scope was clearly understood by all stakeholders from key business leaders to shopfloor operators. Thus, the value of data analytics was apparent. The paper discusses key pitfalls to avoid and identifies two key investments for success.

A Cross-Sectional Study On Perinatal Mortality In Jasin District, Malaysia, Yadneshwar Khobragade

Manipal Journal of Medical Sciences

Background: Since 2003 perinatal mortality rate of Malaysia is in range of 7.5 -8.5/1000. But higher deaths rates were observed in Jasin District from 2014-2017, hence this study was conducted to find out the prevalence and causes of perinatal mortality and suggest the steps to prevent it. Material and Methods: Cross-sectional study was conducted in Jasin district health office. Registered cases for delivery and birth records covering the period of 2014-2017 were checked. Total births (including stillbirths) were 8092. The files of stillbirths and early neonatal deaths were segregated, and data entered in excel sheet. Statistical Analysis: Processing and analysis …

The Impact Of The Global Economic Crisis (1929-1933) On Iraqi Society And The Most Important Topics Covered By The Iraqi National Newspapers, Vian Hussein

Alustath Journal for Human and Social Sciences

My research study relied on the descriptive and analytical approach to monitor and analyze the most important challenges that Iraq faced, and its importance was summarized in the impact of the global economic crisis on Iraq during a period of four years and the challenges that the Iraqi governments faced in this period by preserving the Iraqi economy, market prices and the unemployment rate as indicated in my research what was reported by the national press From the opinion of the Iraqi street about the global economic crisis and the transfer of the suffering of the Iraqi citizen, as well …

The Mujahideen Youth Movement And Its Impact On The Political Reality Of Somalia, Muna Hussein

Alustath Journal for Human and Social Sciences

The Young Mujahideen Movement is one of the Islamic movements that appeared in 2006, and it has a Salafi Islamist orientation that aims to establish a state on the basis of Islamic law. This movement managed to control most aspects of political life in Somalia, specifically in central and southern Somalia, and sought to impose taxes and fees. Zakat on Somali citizens, and the application of strict Sharia provisions in the areas under its control, and perhaps what helped this movement to expand and spread in Somalia is the deteriorating conditions the country is going through, as well as political …

A Study Of The Impact Of Digital Learning: Learning Motivation And Learning Outcomes, Saad Jumaa Farhan, Sanaa Rusly Rajab, Mayadah Abdusalam

Alustath Journal for Human and Social Sciences

In today’s society when smart mobile devices have become popular, the Internet is breaking barriers in time and space and has become a complete learning tool. Designing tutorials for digital education and the rapid use of technology tools, is a key topic for current information technology education. In this study, students are screened and asked questionnaires to understand the concept of digital learning. To successfully fulfill; the research objectives and to test the findings, in-depth studies are included in this study. A total of 116 students in four classes were selected as test subjects for teaching assessments. The findings of …

On The Study Of Age-Related Physiological Decline In C. Elegans, Drew Benjamin Sinha

McKelvey School of Engineering Graduate Student Theses & Dissertations

Aging decline is a universal and unescapable phenomenon; as organisms reach maturity and continue living, physiological function inevitably declines, resulting in mortality. While the study of mortality has been long studied, technical and practical challenges have limited the equally important study of how/when individuals deteriorate and what types of factors affect that deterioration. This gap in knowledge is not only evident in a relative lack of empirical data on physiological decline, but considerable debate around the analysis and conceptual interpretations of the little data that is available.

In this dissertation, I use quantitative reasoning and analysis of longitudinal data to …

Identification Of Candidate Microbial Biomarkers Of Disease And Design Of Engineered Microbial Therapeutics For The Gut Microbiome, Aura Lucia Ferreiro

McKelvey School of Engineering Graduate Student Theses & Dissertations

The human gut microbiome is a compositionally and functionally diverse community of microorganisms that profoundly influences the health of the host. Deep characterization of gut microbiomes via high-throughput sequencing has identified associations between the gut microbiome and disease states, and spurred development of engineered microbial therapeutics. Successful translation of these research efforts to the clinic will involve i) consideration of how engineered microbes behave and adapt in the gut, towards the implementation of biosafety mechanisms, and ii) identification and validation of microbial biomarkers of disease. This dissertation describes both investigative (Chapter 2) and engineering (Chapters 3 and 4) approaches to …

Collaboration Between Librarians And Academics In The Department Of Information Studies For Curriculum Development In Kzn, Petros Pn Dlamini, Bethiweli Mlambo, T Masenya

Library Philosophy and Practice (e-journal)

The aim of this study is to assess the level of collaboration between librarians and Library and Information Science (LIS) academics for the development of the LIS curriculum, being aware that collaboration is an instructional strategy that positively affects student academic achievement. The term collaboration has become popular concept in areas of life where two or more individuals, organisations, institutions or nation embark upon a mutually agreed process. Collaboration provides the opportunity for experts and researchers to partner and fine-tune thoughts and develop strategies for multi-dimensional thinking towards achieving common and uniform practice. Collaboration between librarians and LIS academics has …

Users’ Satisfaction With Resources And Services Of Public Libraries: A Case Of Govt. Jinnah Public Library Sahiwal, Pakistan, Muhammad Tariq Mr, Ahmad Nawaz Mr, Rais Ahmad Samdani Dr

Library Philosophy and Practice (e-journal)

Public libraries play a pivotal role in the development of national culture, society, economy and other factors. Users have extreme importance when libraries are discussed. Good resources and services are essentially required for library users. The objective of this study was to evaluate the users’ satisfaction with the resources and services of a public library. Quantitative research approach based on survey method was used to conduct this study. A structured questionnaire was designed to collect the data from the registered members of Government Jinnah Public Library Sahiwal (GJPLS). Convenience sampling technique was applied to approach sample size of this study. …

Genetic Risk Factors For Neurodevelopmental Disorders: Insights From Hipsc-Cerebral Organoids, Michelle L. Wegscheid

Arts & Sciences Graduate Student Theses and Dissertations

Neurofibromatosis type 1 (NF1) is a common neurodevelopmental disorder (NDD) characterized by remarkable phenotypic variability, where affected children manifest a spectrum of central nervous system (CNS) abnormalities, including brain tumors, impairments in attention, behavior, learning disabilities, and an increased incidence of autism spectrum disorder (ASD). A significant barrier to the implementation of precision medicine strategies for children with NF1 is a lack of prognostic risk factors to guide clinical management. However, emerging population-based genotype-phenotype association studies have suggested that the germline NF1 gene mutation may represent one clinically actionable risk factor for NF1-associated neurodevelopmental abnormalities. As a critical step in …

Acoustic Radiation Force And Its Application For Cell Manipulation And Ion Channels Activation, Xiangjun Peng

McKelvey School of Engineering Graduate Student Theses & Dissertations

Sound is a stress wave that carries energy and momentum flux. Scattered sound waves can generate acoustic radiation force that can be used to manipulate particles or cells. This dissertation demonstrates the physics behind cell manipulation by ultrasound. The work begins with a detailed analysis of the mechanics of using standing surface acoustic waves to fabricate acoustic tweezers for contactless particle manipulation using acoustic radiation force. Models to design and analyze acoustic radiation force have traditionally relied on plane wave theories that cannot predict how standing surface acoustic waves can levitate cells in the direction perpendicular to the substrate. We …

The Effects Of Molecular Chaperone Modulation On Protein Folding, Prion Formation, And Prion Propagation In Saccharomyces Cerevisiae, Leeran Blythe Dublin Ryan

Arts & Sciences Graduate Student Theses and Dissertations

Proper and efficient protein folding is vital for cell survival. Many factors affect protein folding fidelity and prion formation, including molecular chaperone availability and activity. Research has shown that modulating chaperone availability and function can affect protein misfolding and aggregation, as well as de novo prion formation and propagation. However, the factors involved and underlying mechanisms influencing prion formation and protein folding are largely unknown. The following work aims to elucidate these areas. The Nascent Polypeptide-Associated Complex (NAC) is the first point of chaperone contact for nascent polypeptides. Previous work has shown that disruption of the NAC leads to improved …

Human Plcg2 Haploinsufficiency Results In A Novel Immunodeficiency, Joshua Brandon Alinger

Arts & Sciences Graduate Student Theses and Dissertations

NK cells are critical for the recognition and lysis of herpesvirus-infected cells. Patients with NK cell immunodeficiency may suffer from unusually severe and/or recurrent herpesvirus infections; however, the genetic cause is frequently unknown. PLCG2 encodes a signaling protein in NK cell and B cell receptor signaling, in which dominant-negative or gain-of-function mutations may cause cold urticaria, antibody deficiency, or autoinflammation. However, loss-of-function mutations and PLCG2 haploinsufficiency have never been reported in human disease. We examined 2 families with autosomal dominant NK cell immunodeficiency with dual high-dimensional techniques, mass cytometry and whole-exome sequencing, to identify the cause of disease. We identified …

Developments In Proteomics, Trans-Splicing Technology And Endogenous Transcript Manipulation, Justin Alexander Melendez

Arts & Sciences Graduate Student Theses and Dissertations

Technological innovation drives scientific discovery, unlocks new avenues of research, and allows us to ask questions in ways that were previously unavailable. With each technological advance, our ability to perturb and explore biological systems has grown in ways previously unimagined. The theme of my thesis is the development of new technologies in biology. To this end, I have worked on three technologies that contribute to the areas of protein sequencing, RNA barcoding for trans-splicing and single-cell applications, and a new method for transcriptional knockdown. In my first project, digital analysis of proteins by end sequencing (DAPES), we set out to …