Digital Commons Network^™

Association Of Β-Amyloid Level, Clinical Progression And Longitudinal Cognitive Change In Normal Older Individuals, Laura M. Van Der Krall, Thanh Truong, Samantha C. Burnham, Vincent Doré, Rachel S. Mulligan, Svetlana Bozinovski, Fiona Lamb, Pierrick Bourgeat, Jurgen Fripp, Stephanie Schultz, Yen Y. Lim, Simon M. Laws, David Ames, Christopher Fowler, Stephanie R. Rainey-Smith, Ralph N. Martins, Olivier Salvado, Joanne Robertson, Paul Maruff, Colin L. Masters, Victor L. Villemagne, Christopher C. Rowe

Research outputs 2014 to 2021

Objective To determine the effect of β-amyloid (Aβ) level on progression risk to mild cognitive impairment (MCI) or dementia and longitudinal cognitive change in cognitively normal (CN) older individuals. Methods All CN from the Australian Imaging Biomarkers and Lifestyle study with Aβ PET and ≥ 3 years follow-up were included (n = 534; age 72 ± 6 years; 27% Aβ positive; follow-up 5.3 ± 1.7 years). Aβ level was divided using the standardized 0–100 Centiloid scale: < 15 CL negative, 15–25 CL uncertain, 26–50 CL moderate, 51–100 CL high, > 100 CL very high, noting > 25 CL approximates a positive scan. Cox proportional hazards analysis and linear mixed effect models were used to assess …

A Narrative Review Of The Pharmacological, Cultural And Psychological Literature On Ibogaine, Martie S. Underwood, Stephen J. Bright, B. Les Lancaster

Research outputs 2014 to 2021

Ibogaine is a psychoactive alkaloid contained in the West African plant Tabernanthe iboga. Although preliminary, evidence suggests that ibogaine could be effective in the treatment of certain substance use disorders, specifically opioid use disorder. This narrative review concentrated on the pharmacological, cultural and psychological aspects of ibogaine that contribute to its reputed effectiveness with a specific focus on the ibogaine state of consciousness. Although the exact pharmacological mechanisms for ibogaine are still speculative, the literature highlighted its role as an NMDA antagonist in the effective treatment of substance use disorders. The cultural aspects associated with the use of ibogaine pose …

Utilizing The Food–Pathogen Metabolome To Putatively Identify Biomarkers For The Detection Of Shiga Toxin-Producing E. Coli (Stec) From Spinach, Snehal R. Jadhav, Rohan M. Shah, Avinash V. Karpe, Robert S. Barlow, Kate E. Mcmillan, Michelle L. Colgrave, David J. Beale

Research outputs 2014 to 2021

Shiga toxigenic E. coli (STEC) are an important cause of foodborne disease globally with many outbreaks linked to the consumption of contaminated foods such as leafy greens. Existing methods for STEC detection and isolation are time-consuming. Rapid methods may assist in preventing contaminated products from reaching consumers. This proof-of-concept study aimed to determine if a metabolomics approach could be used to detect STEC contamination in spinach. Using untargeted metabolic profiling, the bacterial pellets and supernatants arising from bacterial and inoculated spinach enrichments were investigated for the presence of unique metabolites that enabled categorization of three E. coli risk groups. A …

Impact Of Enhanced Enterprise Resource Planning (Erp) On Firm Performance Through Green Supply Chain Management, Zeplin J. H. Tarigan, Hotlan Siagian, Ferry Jie

Research outputs 2014 to 2021

This study investigates the impact of enhanced enterprise resource planning (ERP) on firm performance through green supply chain management, supplier integration, and internal integration. The population is the manufacturer domiciled in East Java, Indonesia, which has implemented ERP and been certified by the International Organization for Standardization (ISO) in the environmental management system. Data collection used a questionnaire designed with the five-point Likert scale. Of 243 manufacturers, 150 questionnaires were distributed, and 135 questionnaires are considered valid for analysis. Data analysis used smart PLS software. The result indicated that all eight predetermined hypotheses were supported. Enhanced ERP affects supplier integration, …

Supply Chain Integration Enables Resilience, Flexibility, And Innovation To Improve Business Performance In Covid-19 Era, Hotlan Siagian, Zeplin J. H. Tarigan, Ferry Jie

Research outputs 2014 to 2021

The COVID-19 pandemic has brought about a sudden change from normal conditions to disruption conditions, and industrial sectors have experienced eroded growth. In particular, the manufacturing industry experienced a slowdown due to the sudden disruption in supply and demand. This situation stimulates the manufacturing industry to recover from this current challenging disruption. This study investigates the impact of supply chain integration on business performance through supply chain resilience, supply chain flexibility, and innovation system in Indonesia’s manufacturing companies. Data collection has obtained as many as 470 questionnaires considered valid for further analysis. Data analysis used the partial least square (PLS) …

Evaluating The Impact Of Sandbox Applications On Live Digital Forensics Investigation, Reem Bashir, Helge Janicke, Wen Zeng

Research outputs 2014 to 2021

Sandbox applications can be used as anti-forensics techniques to hide important evidence in the digital forensics investigation. There is limited research on sandboxing technologies, and the existing researches on sandboxing are focusing on the technology itself. The impact of sandbox applications on live digital forensics investigation has not been systematically analysed and documented. In this study, we proposed a methodology to analyse sandbox applications on Windows systems. The impact of having standalone sandbox applications on Windows operating systems image was evaluated. Experiments were conducted to examine the artefacts of three sandbox applications: Sandboxie, BufferZone and ToolWiz Time Freeze on Windows …

The Impact Of Nurse Staffing Methodologies On Nurse And Patient Outcomes: A Systematic Review, Diane E. Twigg, Lisa Whitehead, Gemma Doleman, Sonia El-Zaemey

Research outputs 2014 to 2021

Aim

Aim of this study is to systematically review and synthesize available evidence to identify the association between nurse staffing methodologies and nurse and patient outcomes.

Design

Systematic review and narrative synthesis.

Data sources

A search of MEDLINE (EBSCO), CINAHL (EBSCO) and Web of Science was conducted for studies published in English between January 2000 and January 2020.

Review methods

The reporting of this review and narrative synthesis was guided by the preferred reporting items for systematic and meta-analysis guidelines (PRISMA) statement and data synthesis guided by the Synthesis Without Meta-analysis (SWiM) guideline. The quality of each article was assessed …

The Cognitive Development Of Food Taste Perception In A Food Tourism Destination: A Gastrophysics Approach, Sangkyun (Sean) Kim, Eerang Park, Yi Fu, Fan Jiang

Research outputs 2014 to 2021

This study aims to explore the nature and processes involved in the cognitive development of food tourist's taste perception and identify cognitive factors influencing their food taste experience in the context of a food tourism destination. Adopting a gastrophysics approach, this exploratory qualitative research analyses food taste perceptions of Chinese domestic tourists during their visit to the Hangzhou Cuisine Museum and its associated restaurants. The findings suggest that prior knowledge formation as a manifestation of cognitive signs relating to Hangzhou cuisine and interpretive cognitive information acquired at the museum exhibition, greatly affect the tourists' local food taste experiences: these comprise …

Genome Wide Association Study Of Response To Interval And Continuous Exercise Training: The Predict-Hiit Study, Camilla J. Williams, Zhixiu Li, Nicholas Harvey, Rodney A. Lea, Brendon J. Gurd, Jacob T. Bonafiglia, Ioannis Papadimitriou, Macsue Jacques, Ilaria Croci, Dorthe Stensvold, Ulrik Wisloff, Jenna L. Taylor, Trishan Gajanand, Emily R. Cox, Joyce S. Ramos, Robert G. Fassett, Jonathan P. Little, Monique E. Francois, Christopher M. Hearon Jr, Satyam Sarma, Sylvan L. J. E. Janssen, Emeline M. Van Craenenbroeck, Paul Beckers, Véronique A. Cornelissen, Erin J. Howden, Shelley E. Keating, Xu Yan, David J. Bishop, Anja Bye, Larisa M. Haupt, Lyn R. Griffiths, Kevin J. Ashton, Matthew A. Brown, Luciana Torquati, Nir Eynon, Jeff S. Coombes

Research outputs 2014 to 2021

Background: Low cardiorespiratory fitness (V̇O2peak) is highly associated with chronic disease and mortality from all causes. Whilst exercise training is recommended in health guidelines to improve V̇O2peak, there is considerable inter-individual variability in the V̇O2peak response to the same dose of exercise. Understanding how genetic factors contribute to V̇O2peak training response may improve personalisation of exercise programs. The aim of this study was to identify genetic variants that are associated with the magnitude of V̇O2peak response following exercise training. Methods: Participant change in objectively measured V̇O2peak from 18 different interventions was obtained from a multi-centre study (Predict-HIIT). A genome-wide association …

Mixed Methods Study Into Social Impacts Of Work-Related Heat Stress On Ghanaian Mining Workers: A Pragmatic Research Approach, Victor Fannam Nunfam

Research outputs 2014 to 2021

Although mixed methods research proves significant in understanding complex social phenomenon, inadequate research has explored its utility in heat exposure studies. The convergent mixed methods analysis comprising 320 surveys and two focus group interviews were used to evaluate the social impacts of occupational heat stress on Ghanaian mineworkers to enlighten policy choices for the purpose of complementarity. The study contributes to mixed methods study by affirming the practical use of between-method triangulation and complementarity. The merged quantitative and qualitative results also showed adequate corroboration and complementarity between both data, to illustrate the social impacts of work-related heat stress on mining …

Effects Of Shot Peening On Microstructure Evolution And Mechanical Properties Of Surface Nanocrystal Layer On Titanium Matrix Composite, Yan Wen, Yaya Wu, Lin Hua, Lechun Xie, Liqiang Wang, Lai-Chang Zhang, Weijie Lu

Research outputs 2014 to 2021

Shot peening (SP) was employed to modify the surface microstructure and mechanical properties of (TiB+TiC)/Ti-6Al-4V titanium matrix composite (TMC). And the microstructure evolution and mechanical properties were characterized and analyzed in detail. Transmission electron microscopy (TEM) results illustrated that the surface nanograins were introduced by the effect of SP and the hindering of reinforcements to the matrix deformation. The nanograins were formed near the reinforcement/matrix interface because the matrix was squeezed by both the shots and the reinforcements. Moreover, with increasing the volume fraction of reinforcements, the smaller nanograins were introduced near the interfaces due to the severe deformation between …

Effect Of Exercise Adjunct To Radiation And Androgen Deprivation Therapy On Patient-Reported Treatment Toxicity In Men With Prostate Cancer: A Secondary Analysis Of 2 Randomized Controlled Trials, Oliver Schumacher, Daniel A. Galvão, Dennis R. Taaffe, Nigel Spry, David Joseph, Colin Tang, Raphael Chee, Robert U. Newton

Research outputs 2014 to 2021

Purpose: Physical inactivity, in addition to clinical factors, has been associated with higher levels of late pelvic symptoms in patients with prostate cancer (PCa) after radiation therapy. The aim of this study was to investigate the effect of a structured multicomponent exercise program comprised of aerobic and resistance training as well as impact loading on the prevalence and severity of symptoms commonly resulting from androgen deprivation therapy (ADT) and pelvic radiation therapy. Methods and Materials: We performed a secondary analysis of pooled data from 2 randomized controlled trials that investigated the role of exercise on treatment-related side effects in patients …

Experimental Validation Of Bulk-Graphene As A Thermoelectric Generator, Muhammad Uzair Khan, Amir Naveed, Syed Ehtisham Gillani, Dawar Awan, Muhammad Arif, Shaista Afridi, Muhammad Hamyun, Muhammad Asif, Saadia Tabassum, Muhammad Sadiq, Muhammad Lais, Muhammad Aslam, Saeed Ullah Jan, Zeeshan Ahad

Research outputs 2014 to 2021

Quest for alternate energy sources is the core of most of the research activities these days. No matter how small or large amount of energy can be produced by utilizing the non-conventional techniques and sources, every bit of innovation can reshape the future of energy. In this work, experimental analysis of the thermoelectric (TE) properties of bulk-graphene in the temperature range of (303 to 363) K is presented. Graphene powder was pressed to form a pellet which was used to fabricate the TE device. The effects of temperature on the Seebeck coefficient, electrical and thermal conductivities, and the dimensionless figure …

Communication Surrounding Initiation And Withdrawal Of Non-Invasive Ventilation In Adults With Motor Neuron(E) Disease: Clinicians’ And Family Members’ Perspectives, Charlotte Chapman, Sara Bayes, Moira Sim

Research outputs 2014 to 2021

Introduction: International guidelines recommend that health care clinicians communicate with people with MND and their family members about non-invasive ventilation (NIV) and percutaneous gastrostomy tube (PEG) prior to or at the onset of respiratory symptoms. This study sought to discover the degree to which these recommendations are followed in practice.

Methods: Interpretive Description methodology was employed. Nineteen clinicians experienced in caring for people with MND, six relatives of recently deceased people with MND and one person with MND participated in semi-structured in-depth interviews. Clinicians’ accounts of NIV and PEG related communications were compared to family member participants’ recollections of their …

Resistance Training Load Effects On Muscle Hypertrophy And Strength Gain: Systematic Review And Network Meta-Analysis, Pedro Lopez, Régis Radaelli, Dennis R. Taaffe, Robert U. Newton, Daniel A. Galvão, Gabriel S. Trajano, Juliana L. Teodoro, William J. Kraemer, Keijo Häkkinen, Ronei S. Pinto

Research outputs 2014 to 2021

Purpose This study aimed to analyze the effect of resistance training (RT) performed until volitional failure with low, moderate, and high loads on muscle hypertrophy and muscle strength in healthy adults and to assess the possible participant-, design-, and training-related covariates that may affect the adaptations. Methods Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, MEDLINE, CINAHL, EMBASE, SPORTDiscus, and Web of Science databases were searched. Including only studies that performed sets to volitional failure, the effects of low- ( > 15 repetitions maximum (RM)), moderate- (9-15 RM), and high-load ( ≤ 8 RM) RTs were examined in healthy …

Impact Of Coronavirus Disease 2019 (Covid-19) Outbreak Quarantine, Isolation, And Lockdown Policies On Mental Health And Suicide, Balasankar Ganesan, Adel Al-Jumaily, Kenneth N. K. Fong, Palak Prasad, Surendra Kumar Meena, Raymond Kai-Yu Tong

Research outputs 2014 to 2021

The novel coronavirus disease (COVID-19) pandemic has made a huge impact on people's physical and mental health, and it remains a cause of death for many all over the world. To prevent the spread of coronavirus infection, different types of public health measures (social isolation, quarantine, lockdowns, and curfews) have been imposed by governments. However, mental health experts warn that the prolonged lockdown, quarantine, or isolation will create a “second pandemic” with severe mental health issues and suicides. The quarantined or isolated people may suffer from various issues such as physical inactivity, mental health, economic and social problems. As with …

Covid-19 Disease Severity And Death In Relation To Vitamin D Status Among Sars-Cov-2-Positive Uae Residents, Habiba Alsafar, William B. Grant, Rafiq Hijazi, Maimunah Uddin, Nawal Alkaabi, Guan Tay, Bassam Mahboub, Fatme Al Anouti

Research outputs 2014 to 2021

Insufficient blood levels of the neurohormone vitamin D are associated with increased risk of COVID-19 severity and mortality. Despite the global rollout of vaccinations and promising preliminary results, the focus remains on additional preventive measures to manage COVID-19. Results conflict on vitamin D’s plausible role in preventing and treating COVID-19. We examined the relation between vitamin D status and COVID-19 severity and mortality among the multiethnic population of the United Arab Emirates. Our observational study used data for 522 participants who tested positive for SARS-CoV-2 at one of the main hospitals in Abu Dhabi and Dubai. Only 464 of those …

Effect Of Cutting Parameters And Tool Geometry On The Performance Analysis Of One-Shot Drilling Process Of Aa2024-T3, Muhammad Aamir, Khaled Giasin, Majid Tolouei-Rad, Israr Ud Din, Muhammad I. Hanif, Ugur Kuklu, Danil Y. Pimenov, Muhammad Ikhlaq

Research outputs 2014 to 2021

Drilling is an important machining process in various manufacturing industries. High-quality holes are possible with the proper selection of tools and cutting parameters. This study investigates the effect of spindle speed, feed rate, and drill diameter on the generated thrust force, the formation of chips, post-machining tool condition, and hole quality. The hole surface defects and the top and bottom edge conditions were also investigated using scan electron microscopy. The drilling tests were carried out on AA2024-T3 alloy under a dry drilling environment using 6 and 10 mm uncoated carbide tools. Analysis of Variance was employed to further evaluate the …

Summary Of Fetal Alcohol Spectrum Disorder (Fasd) Among Aboriginal And Torres Strait Islander People, Australian Indigenous Healthinfonet

Research outputs 2014 to 2021

Fetal Alcohol Spectrum Disorder (FASD) is a condition caused by alcohol exposure before birth. During pregnancy, alcohol freely crosses the placenta. The baby cannot process the alcohol and this may result in damage to the baby’s brain and body. Not all babies exposed to alcohol during pregnancy will develop FASD, but there is no safe level of alcohol use during pregnancy. FASD is a lifelong condition that results in cognitive, physical and behavioural disabilities. FASD occurs everywhere in Australia where people drink alcohol. Many women drink during pregnancy before they know they are pregnant and there is a lack of …

Fathers’ Experiences Of Feeding Their Extremely Preterm Infants In Family-Centred Neonatal Intensive Care: A Qualitative Study, Evalotte Mörelius, Sofia Brogren, Sandra Andersson, Siw Alehagen

Research outputs 2014 to 2021

Background:

Extremely preterm infants need advanced intensive care for survival and are usually not discharged before they reach the time of expected birth. In a family-centred neonatal intensive care unit both parents are involved at all levels of care including the feeding process. However, studies focusing on fathers in this situation are scarce. The purpose of this study was to explore the experiences of feeding extremely preterm infants in a neonatal intensive care unit from fathers’ perspectives.

Methods:

The study adopts a qualitative inductive method, reported according to the COREQ checklist. Seven fathers of extremely preterm infants (gestational age 24–27 …

Dietary Fibre Intervention For Gut Microbiota, Sleep, And Mental Health In Adults With Irritable Bowel Syndrome: A Scoping Review, Ran Yan, Lesley J. Andrew, Evania Marlow, Kanita Kunaratnam, Amanda Devine, Ian C. Dunican, Claus T. Christophersen

Research outputs 2014 to 2021

Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder affecting 4–5% of the global population. This disorder is associated with gut microbiota, diet, sleep, and mental health. This scoping review therefore aims to map existing research that has administrated fibre-related dietary intervention to IBS individuals and reported outcomes on at least two of the three following themes: gut microbiota, sleep, and mental health. Five digital databases were searched to identify and select papers as per the inclusion and exclusion criteria. Five articles were included in the assessment, where none reported on all three themes or the combination of gut …

Evaluation Of Work-Integrated Learning: A Realist Synthesis And Toolkit To Enhance University Evaluative Practices, Elizabeth J. Cook

Research outputs 2014 to 2021

Situated in the context of work-integrated learning (WIL), this paper aims to build the evaluative capacity of universities in response to an increasing need for evaluation in higher education. It contributes a realist synthesis of international peer-reviewed literature on university evaluation of WIL, which revealed no use of evaluation theory or approaches by the authors. In response, to support the enhancement of university evaluative practices, this paper offers a toolkit of evaluation theory and approaches, with examples relating to WIL, featuring an evaluation planning tool (RUFDATAE). RUFDATAE is demonstrated using a study from the realist synthesis, to highlight its relevance, …

Sub-Micron Moulding Topological Mass Transport Regimes In Angled Vortex Fluidic Flow, Thaar M. D. Alharbi, Matt Jellicoe, Xuan Luo, Kasturi Vimalanathan, Ibrahim K. Alsulami, Bediea S. Al Harbi, Aghil Igder, Fayed A. J. Alrashaidi, Xianjue Chen, Keith A. Stubbs, Justin M. Chalker, Wei Zhang, Ramiz A. Boulos, Darryl B. Jones, Jamie S. Quinton, Colin L. Raston

Research outputs 2014 to 2021

Shear stress in dynamic thin films, as in vortex fluidics, can be harnessed for generating non-equilibrium conditions, but the nature of the fluid flow is not understood. A rapidly rotating inclined tube in the vortex fluidic device (VFD) imparts shear stress (mechanical energy) into a thin film of liquid, depending on the physical characteristics of the liquid and rotational speed,ω, tilt angle,θ, and diameter of the tube. Through understanding that the fluid exhibits resonance behaviours from the confining boundaries of the glass surface and the meniscus that determines the liquid film thickness, we have established specific topological mass transport regimes. …

Weather Bodies: Experimenting With Dance Improvisation In Environmental Education In The Early Years, Jo Pollitt, Mindy Blaise, Tonya Rooney

Research outputs 2014 to 2021

This paper reports on insights gained from incorporating dance improvisation into a broader early years environmental education ethnographic research project. Findings are reported from a two-day workshop where a dancer was invited to work with young children to attune to the weather through their bodies. In these workshops, the practice of dance improvisation was used as a deliberate interference to disrupt the disconnected and disembodied ways in which weather is often taught to young children. The paper argues that when children attune with weather through the embodied and relational practice of dance improvisation, this challenges the common practice of learning …

Revealing Meaning From Story: The Application Of Narrative Inquiry To Explore The Factors That Influence Decision Making In Relation To The Withdrawal Of Life-Sustaining Treatment In The Intensive Care Unit, Fiona Foxall, Deborah Sundin, Amanda Towell-Barnard Phd, Mnursing, Beverly Ewens, Vivien Kemp, Davina Porock

Research outputs 2014 to 2021

This paper considers the effectiveness of narrative inquiry as a research method in collecting and analyzing stories from a purposive sample of intensive care nurses and doctors, regarding their perceptions of the factors that influence decision-making in relation to the withdrawal of life sustaining treatment. Delaying the withdrawal of treatment when it is clearly indicated, may result in unnecessary patient suffering at the end of life, distress for the family as well as moral distress for staff. In narrative inquiry participants’ first-hand accounts of their experiences are told through story; the focus of analysis is the story, with the story …

Beliefs About Illness And Treatment Decision Modelling During Ill-Health In Arabic Families, Diana Arabiat, Lisa Whitehead, Mohammad Al Jabery, Ayman Hamdan-Mansour, Abeer Shaheen, Eman Abu Sabbah

Research outputs 2014 to 2021

Background: The use of self-prescribed antibiotics and other unproven herbal remedies is common in the Arab world. Understanding how family members decide to manage illness is an important priority for health care providers.

Purpose: This paper presents a new model that can be viewed as an extension to the Health Belief Model and help clarifies the cognitive processes families use to manage illness in an Arab family in Jordan. It aims to generate an understanding of family beliefs about the causes of illness and appraisal of how best to manage illness in an Arab family.

Methods: A qualitative approach using …

Digital Labour And Temporal Priorities Within A Secondary School, Nicola F. Johnson

Research outputs 2014 to 2021

Digital devices and ubiquitous online access contribute to the nature and amount of digital labour conducted by school staff. Drawing on more than 40 interviews with staff at one Australian secondary school, the general nature of this digital labour is presented, then Clancy’s notion of temporal autonomous spaces is introduced and applied to theorise why some teachers used digital technologies constantly in their teaching. The article highlights how some teachers invested their time in learning about and using digital technologies because it enhanced their sense of autonomy and increased their sense of freed time. It theorises how teachers who invest …

Cdk5 Positively Regulates Notch1 Signaling In Pancreatic Cancer Cells By Phosphorylation, Qiaoyun Chu, Liyong Wang, Jie Zhang, Wei Wang, Youxin Wang

Research outputs 2014 to 2021

The marked overexpression of cyclin-dependent kinase 5 (CDK5) or Notch1 receptor, which plays critical roles in pancreatic ductal adenocarcinoma (PDAC) development, has been detected in numerous PDAC cell lines and tissues. Although, a previous study has demonstrated that CDK5 inhibition disrupts Notch1 functions in human umbilical vein endothelial cells, the mechanism underlying Notch1 activation regulated by CDK5 remains unclear. Herein, we identified a physical interaction between CDK5 and Notch1 in PDAC cells, with the Notch1 peptide phosphorylated by CDK5/p25 kinase. CDK5 blockade resulted in the profound inhibition of Notch signaling. Accordingly, CDK5 inhibition sensitized PDAC cell proliferation and migration following …

Effects Of Spaceflight On Musculoskeletal Health: A Systematic Review And Meta-Analysis, Considerations For Interplanetary Travel, Paul Comfort, John J. Mcmahon, Paul A. Jones, Matthew Cuthbert, Kristina Kendall, Jason P. Lake, G. Gregory Haff

Research outputs 2014 to 2021

Background: If interplanetary travel is to be successful over the coming decades, it is essential that countermeasures to minimize deterioration of the musculoskeletal system are as effective as possible, given the increased duration of spaceflight associated with such missions. The aim of this review, therefore, is to determine the magnitude of deconditioning of the musculoskeletal system during prolonged spaceflight and recommend possible methods to enhance the existing countermeasures. Methods: A literature search was conducted using PubMed, Ovid and Scopus databases. 5541 studies were identified prior to the removal of duplicates and the application of the following inclusion criteria: (1) group …

Human Ips Cells Engender Corneal Epithelial Stem Cells With Holoclone-Forming Capabilities, Shinya Watanabe, Ryuhei Hayashi, Yuzuru Sasamoto, Motokazu Tsujikawa, Bruce R. Ksander, Markus H. Frank, Andrew J. Quantock, Natasha Y. Frank, Kohji Nishida

Research outputs 2014 to 2021

Human induced pluripotent stem cells (hiPSCs) can generate a multiplicity of organoids, yet no compelling evidence currently exists as to whether or not these contain tissue-specific, holoclone-forming stem cells. Here, we show that a subpopulation of cells in a hiPSC-derived corneal epithelial cell sheet is positive for ABCB5 (ATP-binding cassette, sub-family B, member 5), a functional marker of adult corneal epithelial stem cells. These cells possess remarkable holoclone-forming capabilities, which can be suppressed by an antibody-mediated ABCB5 blockade. The cell sheets are generated from ABCB5+ hiPSCs that first emerge in 2D eye-like organoids around six weeks of differentiation and display …