Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (2491)
- Life Sciences (963)
- Public Health (908)
- Social and Behavioral Sciences (712)
- Medical Specialties (604)
-
- Physical Sciences and Mathematics (423)
- Diseases (399)
- Education (365)
- Law (340)
- Medical Sciences (334)
- Infectious Disease (263)
- Immunology and Infectious Disease (250)
- Higher Education (236)
- Animal Sciences (220)
- Veterinary Medicine (201)
- Biology (189)
- Nursing (187)
- Ecology and Evolutionary Biology (186)
- Virus Diseases (182)
- Epidemiology (179)
- Environmental Sciences (175)
- Veterinary Microbiology and Immunobiology (156)
- Arts and Humanities (154)
- Zoology (154)
- Health Law and Policy (151)
- Terrestrial and Aquatic Ecology (148)
- Population Biology (146)
- Engineering (145)
- Natural Resources Management and Policy (144)
- Natural Resources and Conservation (144)
- Institution
-
- University of Nebraska - Lincoln (261)
- Washington University School of Medicine (234)
- Western Michigan University (208)
- Aga Khan University (164)
- University of Alabama at Birmingham (159)
-
- TÜBİTAK (150)
- University of Kentucky (108)
- The Texas Medical Center Library (98)
- San Jose State University (92)
- Thomas Jefferson University (87)
- Universitas Indonesia (83)
- University of Memphis (79)
- University of Texas Rio Grande Valley (79)
- University of Nebraska Medical Center (73)
- University of New Mexico (73)
- University of South Carolina (72)
- University of South Florida (69)
- Walden University (66)
- Chulalongkorn University (61)
- University of Louisville (61)
- Children's Mercy Kansas City (56)
- Yale University (56)
- City University of New York (CUNY) (53)
- Touro College and University System (51)
- University of Central Florida (50)
- Louisiana State University (48)
- East Tennessee State University (45)
- University of Plymouth (44)
- University of Rhode Island (44)
- Portland State University (42)
- Keyword
-
- COVID-19 (980)
- Humans (233)
- SARS-CoV-2 (202)
- Michigan (199)
- Symptoms (178)
-
- Syndromic surveillance (176)
- Pandemic (163)
- Coronavirus (142)
- Public health (104)
- Female (99)
- Covid-19 (98)
- Male (80)
- Adult (79)
- School of medicine (77)
- HIV (70)
- Release (62)
- Division of infectious diseases (59)
- Pandemics (58)
- Middle Aged (51)
- Newsletter (51)
- Animals (50)
- Department of medicine (49)
- Health (48)
- Epidemiology (47)
- United States (45)
- Vaccine (42)
- Vaccines (42)
- UAB (40)
- Vaccination (40)
- Aged (37)
- Publication
-
- Open Access Publications (186)
- Michigan COVID-19 Syndromic Surveillance System Data (176)
- United States Department of Agriculture Wildlife Services: Staff Publications (136)
- Turkish Journal of Medical Sciences (103)
- Faculty Publications (100)
-
- Browse All News (99)
- Theses and Dissertations (95)
- Library Philosophy and Practice (e-journal) (80)
- Walden Dissertations and Doctoral Studies (61)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (58)
- Dissertations (51)
- 2020-Current year OA Pubs (47)
- Electronic Theses and Dissertations (41)
- Faculty Scholarship (41)
- Faculty, Staff and Students Publications (40)
- COVID-19 Newsletter (37)
- Honors Theses (37)
- Department of Paediatrics and Child Health (35)
- USF Tampa Graduate Theses and Dissertations (34)
- Bulletins (33)
- Faculty, Staff and Student Publications (32)
- Research outputs 2014 to 2021 (32)
- Saudi Medical Journal (31)
- The University of Louisville Journal of Respiratory Infections (31)
- Manuscripts, Articles, Book Chapters and Other Papers (29)
- Public Health Theses (29)
- Publications and Research (29)
- eReporter (campus newsletter) (28)
- School of Medicine Publications (27)
- Articles (23)
- Publication Type
- File Type
Articles 691 - 720 of 5571
Full-Text Articles in Entire DC Network
Novel Radiographic Presentation Of Primary Syphilis Of The Tonsil, Garrett Camps, Cole Pavelchek, Rami Eldaya, Matthew Parsons
Novel Radiographic Presentation Of Primary Syphilis Of The Tonsil, Garrett Camps, Cole Pavelchek, Rami Eldaya, Matthew Parsons
Open Access Publications
A 61-year-old HIV+ male presented to an infectious disease clinic with a complaint of sore throat. A painless ulcerated mass was discovered on the right tonsil resulting in further evaluation with a CT scan of the neck. Imaging confirmed the presence of a mass centered on the palatine tonsil and associated lymphadenopathy. A presumptive diagnosis of HPV-related squamous cell carcinoma was made due to patient risk factors. However, multiple biopsies found no evidence of carcinoma, but instead revealed the presence of spirochetes that stained positive for
Diagnostics To Support Elimination Of Lymphatic Filariasis-Development Of Two Target Product Profiles, Kimberly Y. Won, Gary J. Weil, Et Al
Diagnostics To Support Elimination Of Lymphatic Filariasis-Development Of Two Target Product Profiles, Kimberly Y. Won, Gary J. Weil, Et Al
Open Access Publications
As lymphatic filariasis (LF) programs move closer to established targets for validation elimination of LF as a public health problem, diagnostic tools capable of supporting the needs of the programs are critical for success. Known limitations of existing diagnostic tools make it challenging to have confidence that program endpoints have been achieved. In 2019, the World Health Organization (WHO) established a Diagnostic Technical Advisory Group (DTAG) for Neglected Tropical Diseases tasked with prioritizing diagnostic needs including defining use-cases and target product profiles (TPPs) for needed tools. Subsequently, disease-specific DTAG subgroups, including one focused on LF, were established to develop TPPs …
Mast Cell Activation Symptoms Are Prevalent In Long-Covid, Leonard B Weinstock, Jill B Brook, Arthur S Walters, Ashleigh Goris, Lawrence B Afrin, Gerhard J Molderings
Mast Cell Activation Symptoms Are Prevalent In Long-Covid, Leonard B Weinstock, Jill B Brook, Arthur S Walters, Ashleigh Goris, Lawrence B Afrin, Gerhard J Molderings
Open Access Publications
OBJECTIVES: Hyper-inflammation caused by COVID-19 may be mediated by mast cell activation (MCA) which has also been hypothesized to cause Long-COVID (LC) symptoms. We determined prevalence/severity of MCA symptoms in LC.
METHODS: Adults in LC-focused Facebook support groups were recruited for online assessment of symptoms before and after COVID-19. Questions included presence and severity of known MCA and LC symptoms and validated assessments of fatigue and quality of life. General population controls and mast cell activation syndrome (MCAS) patients were recruited for comparison if they were ≥18 years of age and never had overt COVID-19 symptoms.
RESULTS: There were 136 …
Associations Between Genetic Variants In The Vitamin D Metabolism Pathway And Severity Of Covid-19 Among Uae Residents, Fatme Al-Anouti, Mira Mousa, Spyridon N. Karras, William B. Grant, Zainab Alhalwachi, Laila Abdel-Wareth, Maimunah Uddin, Nawal Alkaabi, Guan K. Tay, Bassam Mahboub, Habiba Alsafar
Associations Between Genetic Variants In The Vitamin D Metabolism Pathway And Severity Of Covid-19 Among Uae Residents, Fatme Al-Anouti, Mira Mousa, Spyridon N. Karras, William B. Grant, Zainab Alhalwachi, Laila Abdel-Wareth, Maimunah Uddin, Nawal Alkaabi, Guan K. Tay, Bassam Mahboub, Habiba Alsafar
All Works
Vitamin D has many effects on cells in the immune system. Many studies have linked low vitamin D status with severity of COVID-19. Genetic variants involved in vitamin D metabolism have been implicated as potential risk factors for severe COVID-19 outcomes. This study investigated how genetic variations in humans affected the clinical presentation of COVID-19. In total, 646 patients with SARS-CoV-2 infection were divided into two groups: noncritical COVID-19 (n = 453; 70.12%) and a critical group (n = 193; 29.87%). Genotype data on the GC, NADSYN1, VDR, and CYP2R1 genes along with data on serum 25-hydroxyvitamin D levels were …
Opioid Use Disorder: A Crisis Of Concern, Evangella Harville
Opioid Use Disorder: A Crisis Of Concern, Evangella Harville
Electronic Theses and Dissertations
According to a statement from the U.S. Centers for Disease Control and Prevention, between 2000 and 2017, approximately 700,000 people died from drug overdoses in the United States. Approximately 128 persons lose their life each day from an opioid overdose. The data for this study were collected by the vice president of operations at the study site from a preexisting database for 2019 and 2020. The participants were inpatient patients, 18 and older, both male and female, and were from all ethnicities. The study facility was located in Western New York and offered a 30-bed inpatient treatment center with 24-hour …
The Behavioral Si* Model, With Applications To The Swine Flu And Covid-19 Pandemics, Jussi Keppo, Marianna Kudlyak, Elena Quercioli, Lones Smith, Andrea Wilson
The Behavioral Si* Model, With Applications To The Swine Flu And Covid-19 Pandemics, Jussi Keppo, Marianna Kudlyak, Elena Quercioli, Lones Smith, Andrea Wilson
School of Economics and Finance Faculty Publications
The 1927 SIR contagion model is the dynamical system for an infection that passes at a constant rate in random pairwise meetings. Our Behavioral SI* Model assumes that everyone has access to a constant elasticity of avoidance technology. We then derive the passing rate in fully solvable Nash equilibrium of the game where everyone optimizes. The resulting dynamics are log-linear, and incidence is log-linear in prevalence, with slope less than one.
The SI* models yields extreme predictions for major contagions, not realized. At breakout, the SI* models capture exponential growth. In our BSI* model, increasing avoidance behavior bends the curve, …
Efficacy Of Typhoid Conjugate Vaccine In Nepal: Final Results Of A Phase 3, Randomised, Controlled Trial, Mila Shakya, Merryn Voysey, Katherine Theiss-Nyland, Rachel Colin-Jones, Dikshya Pant, Anup Adhikari, Susan Tonks, Yama F Mujadidi, Peter O'Reilly, Olga Mazur, Sarah Kelly, Xinxue Liu, Archana Maharjan, Ashata Dahal, Naheeda Haque, Anisha Pradhan, Suchita Shrestha, Manij Joshi, Nicola Smith, Jennifer Hill, Jenny Clarke, Lisa Stockdale, Elizabeth Jones, Timothy Lubinda, Binod Bajracharya, Sabina Dongol, Abhilasha Karkey, Stephen Baker, Gordan Dougan, Virginia E Pitzer, Kathleen M Neuzil, Shrijana Shrestha, Buddha Basnyat, Andrew J Pollard
Efficacy Of Typhoid Conjugate Vaccine In Nepal: Final Results Of A Phase 3, Randomised, Controlled Trial, Mila Shakya, Merryn Voysey, Katherine Theiss-Nyland, Rachel Colin-Jones, Dikshya Pant, Anup Adhikari, Susan Tonks, Yama F Mujadidi, Peter O'Reilly, Olga Mazur, Sarah Kelly, Xinxue Liu, Archana Maharjan, Ashata Dahal, Naheeda Haque, Anisha Pradhan, Suchita Shrestha, Manij Joshi, Nicola Smith, Jennifer Hill, Jenny Clarke, Lisa Stockdale, Elizabeth Jones, Timothy Lubinda, Binod Bajracharya, Sabina Dongol, Abhilasha Karkey, Stephen Baker, Gordan Dougan, Virginia E Pitzer, Kathleen M Neuzil, Shrijana Shrestha, Buddha Basnyat, Andrew J Pollard
Faculty, Staff and Student Publications
BACKGROUND: Typhoid fever is a major public health problem in low-resource settings. Vaccination can help curb the disease and might reduce transmission. We have previously reported an interim analysis of the efficacy of typhoid conjugate vaccine (TCV) in Nepali children. Here we report the final results after 2 years of follow-up.
METHODS: We did a participant-masked and observer-masked individually randomised trial in Lalitpur, Nepal, in which 20 019 children aged 9 months to younger than 16 years were randomly assigned in a 1:1 ratio to receive a single dose of TCV (Typbar TCV, Bharat Biotech International, India) or capsular group …
Positron Emission Tomography In The Covid-19 Pandemic Era, Chentao Jin, Xiaoyun Luo, Shufang Qian, Kai Zhang, Yuanxue Gao, Rui Zhou, Peili Cen, Zhoujiao Xu, Hong Zhang, Mei Tian
Positron Emission Tomography In The Covid-19 Pandemic Era, Chentao Jin, Xiaoyun Luo, Shufang Qian, Kai Zhang, Yuanxue Gao, Rui Zhou, Peili Cen, Zhoujiao Xu, Hong Zhang, Mei Tian
Faculty, Staff and Student Publications
Coronavirus disease 2019 (COVID-19) has become a major public health problem worldwide since its outbreak in 2019. Currently, the spread of COVID-19 is far from over, and various complications have roused increasing awareness of the public, calling for novel techniques to aid at diagnosis and treatment. Based on the principle of molecular imaging, positron emission tomography (PET) is expected to offer pathophysiological alternations of COVID-19 in the molecular/cellular perspectives and facilitate the clinical management of patients. A number of PET-related cases and research have been reported on COVID-19 over the past one year. This article reviews the current studies of …
Essays On The Impacts Of Extreme Natural Events On Health, Moumita Ghorai
Essays On The Impacts Of Extreme Natural Events On Health, Moumita Ghorai
Dissertations
This dissertation comprises three chapters that examine how extreme events impact health outcomes such as short-term illness, body mass index, probability of pre-term birth, and mortality. The study reveals the severe consequences of these events and shows that certain groups within a particular country are affected disproportionately.
The first chapter examines whether National Rural Employment Guarantee Scheme (NREGS), India’s flagship workfare program, mitigates adverse health outcomes of a drought. This paper contributes to a growing area of research on adaptations to climate change. Using Indian Human Development Survey (2004-2005 and 2010-2011), a nationally representative panel data set, and high resolution …
Latinx Caregivers’ Perceived Need For And Utilization Of Youth Telepsychology Services During The Coronavirus Pandemic, Alejandro L. Vázquez, Cynthia M. Navarro Flores, María De La Caridad Alvarez, Melanie M. Domenech Rodríguez
Latinx Caregivers’ Perceived Need For And Utilization Of Youth Telepsychology Services During The Coronavirus Pandemic, Alejandro L. Vázquez, Cynthia M. Navarro Flores, María De La Caridad Alvarez, Melanie M. Domenech Rodríguez
Psychology Faculty Publications
Telepsychology has the potential to provide a safe method of addressing mental health problems among Latinx youth during the coronavirus pandemic. However, the extent to which Latinx caregivers are accessing telepsychology services for their child and whether this format is perceived to be an appropriate method of addressing youth psychopathology is unknown. The present study examined indicators of youth psychopathology and external stressors in relation to Latinx caregivers’ perceived need for and utilization of youth telepsychology during the coronavirus pandemic. The sample consisted of 598 Latinx caregivers of school-age youths (MAge = 11.9, SD = 3.4) from across the United …
Comorbid Patterns Of Anaemia And Diarrhoea Among Children Aged Under 5 Years In Ghana: A Multivariate Complex Sample Logistic Regression Analysis And Spatial Mapping Visualisation, Henry Ofori Duah, Charles Enyaah Amankwa, Emmanuel Brenyah Adomako, Benson Owusu, Pascal Agbadi
Comorbid Patterns Of Anaemia And Diarrhoea Among Children Aged Under 5 Years In Ghana: A Multivariate Complex Sample Logistic Regression Analysis And Spatial Mapping Visualisation, Henry Ofori Duah, Charles Enyaah Amankwa, Emmanuel Brenyah Adomako, Benson Owusu, Pascal Agbadi
College of Nursing Faculty Research and Publications
Background
Anaemia and diarrhoea are known independent causes of under-five morbidity and mortality. This study sought to investigate predictors of comorbid patterns of anaemia and diarrhoea using the 2014 Ghana Demographic and Health Survey (GDHS). Methods
The study employed analysis of secondary data from the 2014 GDHS. We performed a multivariate complex sample logistic regression and spatial analysis. Results
The weighted prevalence of comorbid anaemia and diarrhoea was 9.28% with the highest burden (16.45%) found in the Upper West region. Independent predictors (risk factors) of comorbid patterns of anaemia and diarrhoea were children aged 6–23 mo (OR=2.17, 95% CI 1.42 …
Diagnostics To Support Elimination Of Lymphatic Filariasis-Development Of Two Target Product Profiles, Kimberly Y. Won, Katherine Gass, Marco Biamonte, Daniel Argaw Dagne, Camilla Ducker, Christopher Hanna, Achim Hoerauf, Patrick J. Lammie, Sammy M. Njenga, Rahmah Noordin, Kapa D. Ramaiah, Reda Ramzy, Ronaldo G.Carvalho Scholte, Anthony W. Solomon, Ashley A. Souza, Jordan Tappero, Emily Toubali, Gary J. Weil, Steven A. Williams, Jonathan D. King
Diagnostics To Support Elimination Of Lymphatic Filariasis-Development Of Two Target Product Profiles, Kimberly Y. Won, Katherine Gass, Marco Biamonte, Daniel Argaw Dagne, Camilla Ducker, Christopher Hanna, Achim Hoerauf, Patrick J. Lammie, Sammy M. Njenga, Rahmah Noordin, Kapa D. Ramaiah, Reda Ramzy, Ronaldo G.Carvalho Scholte, Anthony W. Solomon, Ashley A. Souza, Jordan Tappero, Emily Toubali, Gary J. Weil, Steven A. Williams, Jonathan D. King
Biological Sciences: Faculty Publications
As lymphatic filariasis (LF) programs move closer to established targets for validation elimination of LF as a public health problem, diagnostic tools capable of supporting the needs of the programs are critical for success. Known limitations of existing diagnostic tools make it challenging to have confidence that program endpoints have been achieved. In 2019, the World Health Organization (WHO) established a Diagnostic Technical Advisory Group (DTAG) for Neglected Tropical Diseases tasked with prioritizing diagnostic needs including defining use-cases and target product profiles (TPPs) for needed tools. Subsequently, disease-specific DTAG subgroups, including one focused on LF, were established to develop TPPs …
Healthcare System-To-System Cost Variability In The Care Of Pediatric Abdominal Pain-Associated Functional Gastrointestinal Disorders, Michelle Livitz, Alec S. Friesen, Earl F. Glynn, Jennifer V. Schurman, Jennifer M. Colombo, Craig A. Friesen
Healthcare System-To-System Cost Variability In The Care Of Pediatric Abdominal Pain-Associated Functional Gastrointestinal Disorders, Michelle Livitz, Alec S. Friesen, Earl F. Glynn, Jennifer V. Schurman, Jennifer M. Colombo, Craig A. Friesen
Student Publications
The purpose of this study was to assess cost variability in the care of abdominal pain-associated functional gastrointestinal disorders (AP-FGIDS) in youth across health systems, races, and specific AP-FGID diagnoses. Patients, aged 8-17 years, with a priority 1 diagnosis corresponding to a Rome IV defined AP-FGID were identified within the Health Facts® database. Total costs were obtained across the continuum of care including outpatient clinics, emergency department, and inpatient or observation units. Cost variability was described comparing different health systems, races, and diagnoses. Thirteen thousand two hundred and fourteen patients were identified accounting for 17,287 encounters. Total costs were available …
Social And Safety Monitoring For Pandemic With Yolo, Cl Chung, H Samani, Ly Yu, Cy Yang
Social And Safety Monitoring For Pandemic With Yolo, Cl Chung, H Samani, Ly Yu, Cy Yang
School of Engineering, Computing and Mathematics
During the pandemic of COVID-19, people have been suggested to keep social distance from the others. It is also beneficial to pay attention to the individuals with motion irregularities. In this research, we propose a visual anomaly analysis system based on deep learning with the aim to identify individuals with various types of anomaly which are specifically important during the pandemic. Based on the proposed monitoring system it would be easier to keep tracking the environment changes, and it would also be beneficial to the safety guard to reallocate resources accordingly to relieve the threat of anomaly. Types of the …
Uk B.1.1.7 (Alpha) Variant Exhibits Increased Respiratory Replication And Shedding In Nonhuman Primates, Kyle Rosenke, F Feldmann, Atsushi Okumura, Frederick Hansen, Tsing Lee Tang-Huau, Kimberly Meade-White, Benjamin Kaza, Julie Callison, Matthew C. Lewis, Brian J. Smith, Patrick W. Hanley, Jamie Lovaglio, Michael A. Jarvis, Carl Shaia, H Feldmann
Uk B.1.1.7 (Alpha) Variant Exhibits Increased Respiratory Replication And Shedding In Nonhuman Primates, Kyle Rosenke, F Feldmann, Atsushi Okumura, Frederick Hansen, Tsing Lee Tang-Huau, Kimberly Meade-White, Benjamin Kaza, Julie Callison, Matthew C. Lewis, Brian J. Smith, Patrick W. Hanley, Jamie Lovaglio, Michael A. Jarvis, Carl Shaia, H Feldmann
School of Biomedical Sciences
The continuing emergence of SARS-CoV-2 variants calls for regular assessment to identify differences in viral replication, shedding and associated disease. In this study, we compared African green monkeys infected intranasally with either the UK B.1.1.7 (Alpha) variant or its contemporary D614G progenitor. Both variants caused mild respiratory disease with no significant differences in clinical presentation. Significantly higher levels of viral RNA and infectious virus were found in upper and lower respiratory tract samples and tissues from B.1.1.7 infected animals. Interestingly, D614G infected animals showed significantly higher levels of viral RNA and infectious virus in rectal swabs and gastrointestinal tissues. Our …
Biosensor Devices Based On Graphene And 2d Materials, Suhada Aidrous Poovathy
Biosensor Devices Based On Graphene And 2d Materials, Suhada Aidrous Poovathy
Theses
Nanomaterials offered new improvements and developments to the bio-sensing field due to their unique physical and chemical properties. Unique and exceptional electronic properties, such as the ultrahigh surface-to-volume ratio and the excellent electrical properties of the 2D materials like in graphene, making these materials promising for future smaller and faster electronics, but an extensive amount of research is still needed. This thesis is concerned with the study of the integration of 2D material graphene in the development of sensitive and rapid biosensors. The main objective of this thesis is to understand the features and characteristics of graphene, evaluate the scope …
Microbiota From Specific Pathogen-Free Mice Reduces Campylobacter Jejuni Chicken Colonization, Ayidh Almansour, Ying Fu, Tahrir Jatli Alenezi, Mohit Bansal, Bilal Alrubaye, Hong Wang, Xiaolun Sun
Microbiota From Specific Pathogen-Free Mice Reduces Campylobacter Jejuni Chicken Colonization, Ayidh Almansour, Ying Fu, Tahrir Jatli Alenezi, Mohit Bansal, Bilal Alrubaye, Hong Wang, Xiaolun Sun
Poultry Science Faculty Publications and Presentations
Campylobacter jejuni, a prevalent foodborne bacterial pathogen, is mainly transmitted from poultry with few effective prevention approaches. In this study, we aimed to investigate the role of microbiota on C. jejuni chicken colonization. Microbiota from specific pathogen-free (SPF) mouse stools were collected as SPF-Aerobe and SPF-Anaerobe. Birds were colonized with SPF-Aerobe or SPF-Anaerobe at day 0 and infected with C. jejuni AR101 at day 12. Notably, C. jejuni AR101 colonized at 5.3 and 5.6 log(10) C. jejuni CFU/g chicken cecal digesta at days 21 and 28, respectively, while both SPF-Aerobe and SPF-Anaerobe microbiota reduced pathogen colonization. Notably, SPF-Aerobe and SPF-Anaerobe …
A Qualitative Phenomenological Study On Moral Distress And The Nursing Student During The Covid-19 Pandemic, Alan Peter Howard
A Qualitative Phenomenological Study On Moral Distress And The Nursing Student During The Covid-19 Pandemic, Alan Peter Howard
Doctoral Dissertations and Projects
The purpose of this phenomenological study was to explore the phenomenon of moral distress on nursing students who engaged in clinical experiences during the COVID-19 pandemic. This research study was supported by Jean Watson’s theory of human caring (Watson, 2006) as it explained the relationship between a nursing students’ provision of care and the moral dilemma and potential moral distress related to threats to that care. This study was also presented within the conceptual framework of Patricia Benner’s model from novice to expert (Benner, 1984). Within this framework, the nursing student as novice may not have the skills or experience …
Genome-Wide Association Study Of Problematic Opioid Prescription Use In 132,113 23andme Research Participants Of European Ancestry, Sandra Sanchez-Roige, Pierre Fontanillas, Mariela V Jennings, Sevim B Bianchi, Yuye Huang, Alexander S Hatoum, Julia Sealock, Lea K Davis, Sarah L Elson, 23andme Research Team, Abraham A Palmer
Genome-Wide Association Study Of Problematic Opioid Prescription Use In 132,113 23andme Research Participants Of European Ancestry, Sandra Sanchez-Roige, Pierre Fontanillas, Mariela V Jennings, Sevim B Bianchi, Yuye Huang, Alexander S Hatoum, Julia Sealock, Lea K Davis, Sarah L Elson, 23andme Research Team, Abraham A Palmer
2020-Current year OA Pubs
The growing prevalence of opioid use disorder (OUD) constitutes an urgent health crisis. Ample evidence indicates that risk for OUD is heritable. As a surrogate (or proxy) for OUD, we explored the genetic basis of using prescription opioids 'not as prescribed'. We hypothesized that misuse of opiates might be a heritable risk factor for OUD. To test this hypothesis, we performed a genome-wide association study (GWAS) of problematic opioid use (POU) in 23andMe research participants of European ancestry (N = 132,113; 21% cases). We identified two genome-wide significant loci (rs3791033, an intronic variant of KDM4A; rs640561, an intergenic variant near …
Simultaneous Brain And Intramedullary Spinal Abscesses In A Patient With Streptococcus Intermedius Infection, David P. Friedman, Joseph Desimone Jr, Aaron Christensen, Matthew Pettengill
Simultaneous Brain And Intramedullary Spinal Abscesses In A Patient With Streptococcus Intermedius Infection, David P. Friedman, Joseph Desimone Jr, Aaron Christensen, Matthew Pettengill
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
A male patient in his thirties presented to the hospital with meningismus and altered mental status. Cerebrospinal fluid (CSF) analysis confirmed meningitis, but no microorganisms were identified. Head imaging (MRI) revealed multiple brain abscesses. Surgically-collected brain specimens revealed Gram-positive cocci and subsequently grew Streptococcus intermedius. MRI of the thoracic spine subsequently also identified an intramedullary spinal abscess. While brain abscesses and spinal abscesses caused by S. intermedius have been previously reported, the extent of disseminated disease in the patient was noteworthy.
Contributions Of Iranian Journal Of Medical Sciences (Ijms) During The Covid-19 Pandemic., A A Asadi-Pooya, Mohsen Farazdaghi, Marzieh Rostaminejad, Manica Negahdaripour
Contributions Of Iranian Journal Of Medical Sciences (Ijms) During The Covid-19 Pandemic., A A Asadi-Pooya, Mohsen Farazdaghi, Marzieh Rostaminejad, Manica Negahdaripour
Department of Neurology Faculty Papers
No abstract provided.
Microbial Dark Matter: Culturing The Uncultured In Search Of Novel Chemotaxonomy, Sarah J. Kennedy
Microbial Dark Matter: Culturing The Uncultured In Search Of Novel Chemotaxonomy, Sarah J. Kennedy
USF Tampa Graduate Theses and Dissertations
Although <1% of environmental isolates can be cultured, insights into the culturable fraction refine future techniques to unlock the cryptic biodiversity. This cryptic biodiversity is omnipresent within culture-independent surveys of environmental bacterial populations. Subsequently, these elusive organisms are termed “microbial dark matter” due to the intrigue surrounding their potential taxonomic and biosynthetic impacts. To this end of investigating bacterial-specific dark matter, we employed high-throughput culturing techniques to examine Gulf of Mexico sediments and sponges for chemotaxonomically important bacteria. Through stepwise implementation of permissive and selective recovery techniques, we succeeded in recovering over 150 unique bacterial isolates. We observed several isolates that pose as chemotaxonomically interesting, including several strains that belong to critical bioremediation taxa. In addition to these biotechnological-amenable isolates, we have also succeeded in culturing taxa historically attributed with antibacterial discoveries. One such isolate was a previously sponge-associated organism belonging to the rarely cultured Verrucosispora genus. Through extensive comparative genomics, we identified it as a novel species and subsequently named it Verrucosispora sioxanthis sp. nov. with the published genome serving as a resource for continued microbial dark matter investigations. Following continued passaging of the organism, we observed improved growth, biomass, and liquid growth dispersal within each increasingly sub-passaged generation of the isolate. As such, the laboratory attenuation, or domestication, of the organism warranted in-depth whole genomic analyses to generate insight into the increased laboratory sustainability. Through phenotypically-guided bioinformatics, we determined that the domestication was mediated through genome-wide selective pseudo- or non-pseudogenization of genes. As the previously sponge-associated organism evolved with the selection pressures of the static laboratory, we demonstrate that isolate effectively underwent genomic atrophy to resolve into a largely stable, sustainable laboratory-domesticated strain. Collectively, our chemotaxonomic discovery pipeline expands on the culturable bacterial biodiversity and ultimately provides a previously uncultured model organism for initial forays into resolving the microbial dark matter knowledge gap.
Drivers Of Transcriptional Variance In Human Intestinal Epithelial Organoids, Zachary K Criss, Nobel Bhasin, Sara C Di Rienzi, Anubama Rajan, Kali Deans-Fielder, Ganesh Swaminathan, Nabiollah Kamyabi, Xi-Lei Zeng, Harsha Doddapaneni, Vipin K Menon, Deepavali Chakravarti, Clarissa Estrella, Xiaomin Yu, Ketki Patil, Joseph F Petrosino, James C Fleet, Michael P Verzi, Sylvia Christakos, Michael A Helmrath, Sumimasa Arimura, Ronald A Depinho, Robert A Britton, Anthony W Maresso, K Jane Grande-Allen, Sarah E Blutt, Sue E Crawford, Mary K Estes, Sasirekha Ramani, Noah F Shroyer
Drivers Of Transcriptional Variance In Human Intestinal Epithelial Organoids, Zachary K Criss, Nobel Bhasin, Sara C Di Rienzi, Anubama Rajan, Kali Deans-Fielder, Ganesh Swaminathan, Nabiollah Kamyabi, Xi-Lei Zeng, Harsha Doddapaneni, Vipin K Menon, Deepavali Chakravarti, Clarissa Estrella, Xiaomin Yu, Ketki Patil, Joseph F Petrosino, James C Fleet, Michael P Verzi, Sylvia Christakos, Michael A Helmrath, Sumimasa Arimura, Ronald A Depinho, Robert A Britton, Anthony W Maresso, K Jane Grande-Allen, Sarah E Blutt, Sue E Crawford, Mary K Estes, Sasirekha Ramani, Noah F Shroyer
Faculty, Staff and Students Publications
Human intestinal epithelial organoids (enteroids and colonoids) are tissue cultures used for understanding the physiology of the human intestinal epithelium. Here, we explored the effect on the transcriptome of common variations in culture methods, including extracellular matrix substrate, format, tissue segment, differentiation status, and patient heterogeneity. RNA-sequencing datasets from 276 experiments performed on 37 human enteroid and colonoid lines from 29 patients were aggregated from several groups in the Texas Medical Center. DESeq2 and gene set enrichment analysis (GSEA) were used to identify differentially expressed genes and enriched pathways. PERMANOVA, Pearson's correlation, and dendrogram analysis of the data originally indicated …
Comparison Of Culture With Antibiogram To Next-Generation Sequencing Using Bacterial Isolates And Formalin-Fixed, Paraffin-Embedded Gastric Biopsies, Kristina G Hulten, Robert M Genta, Ira N Kalfus, Yi Zhou, Hongjun Zhang, David Y Graham
Comparison Of Culture With Antibiogram To Next-Generation Sequencing Using Bacterial Isolates And Formalin-Fixed, Paraffin-Embedded Gastric Biopsies, Kristina G Hulten, Robert M Genta, Ira N Kalfus, Yi Zhou, Hongjun Zhang, David Y Graham
Faculty, Staff and Students Publications
BACKGROUND & AIMS: The decline in Helicobacter pylori cure rates emphasizes the need for readily available methods to determine antimicrobial susceptibility. Our aim was to compare targeted next-generation sequencing (NGS) and culture-based H pylori susceptibility testing using clinical isolates and paired formalin-fixed, paraffin-embedded (FFPE) gastric biopsies.
METHODS: H pylori isolates and FFPE tissues were tested for susceptibility to amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, and rifabutin using agar dilution and NGS targeted to 23S rRNA, gyrA, 16S rRNA, pbp1, rpoB and rdxA. Agreement was quantified using κ statistics.
RESULTS: Paired comparisons included 170 isolates and FFPE tissue for amoxicillin, clarithromycin, metronidazole, …
Vaccine Clinical Trials And Data Infrastructure, Ana Santos Rutschman
Vaccine Clinical Trials And Data Infrastructure, Ana Santos Rutschman
Faculty Publications
We find ourselves at a momentous turn in the history of vaccines. The COVID-19 pandemic triggered a quasi-global vaccine race that not only compressed vaccine research and development (R&D) timelines, but also paved the way for the administration of a new type of vaccine technology – mRNA vaccines, which work in substantially different ways from the vaccines in use before the pandemic.
While the process of bringing emerging COVID-19 vaccines to market has taken place in an unusually short timeframe, it was largely predicated on the same scientific and regulatory processes that govern the development, approval and deployment of new …
2021-10-31_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services
2021-10-31_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services
Michigan COVID-19 Syndromic Surveillance System Data
The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated three times a week on Mondays, Wednesdays and Fridays.
Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Care) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, …
Psychosocial Factors Associated With Mask-Wearing Behavior During The Covid-19 Pandemic, Cliff (Yung-Chi) Chen, Mengjia Lei
Psychosocial Factors Associated With Mask-Wearing Behavior During The Covid-19 Pandemic, Cliff (Yung-Chi) Chen, Mengjia Lei
Publications and Research
Although increasing evidence has supported the efficacy of masks to prevent the spread of the coronavirus (COVID-19), inconsistent and noncompliant mask-wearing behavior has been observed among members of the society. Because mask-wearing is often considered a social contract, it is important to understand the psychosocial factors that influence people’s mask-wearing behavior in order to implement the necessary steps to respond to the pandemic. Based on the protection motivation theory (PMT), this study examined the cognitive factors (threat and coping appraisals) that contribute to mask-wearing behavior and the intention to engage in health protective behavior until the end of the pandemic. …
Reporting In The Age Of Pandemics: (The Case Of Covid-19), Ethics, Techniques, Challenges And Recommendations?, Musa Sabedini
Reporting In The Age Of Pandemics: (The Case Of Covid-19), Ethics, Techniques, Challenges And Recommendations?, Musa Sabedini
UBT International Conference
The history of COVID-19 has profoundly affected both, professional and personal aspect of journalists - from psychological trauma and refined investigations, to health risks for their families. When COVID-19 began to spread rapidly, journalists of all sectors didn’t find it easy to report from the field, nor they had easy access to certain areas. All this psychological "terror" unavoidably resulted with consequences and negative effects in daily reporting routines, particularly to online reporting. Reporting for online media seemed a bit easier at first sight, however it was not easy at all to present the findings to the public. There were …
International Conference Medicine And Nursing, University For Business And Technology - Ubt
International Conference Medicine And Nursing, University For Business And Technology - Ubt
UBT International Conference
UBT Annual International Conference is the 9th international interdisciplinary peer reviewed conference which publishes works of the scientists as well as practitioners in the area where UBT is active in Education, Research and Development. The UBT aims to implement an integrated strategy to establish itself as an internationally competitive, research-intensive university, committed to the transfer of knowledge and the provision of a world-class education to the most talented students from all background. The main perspective of the conference is to connect the scientists and practitioners from different disciplines in the same place and make them be aware of the recent …
Knowledge, Attitudes And Practices Regarding The Use Of Antibiotics: A Cross-Sectional Study From A Rural Area Of Lebanon, Carine Mounzer, Safaa Baydoun, Ranya Amer, Jamilah Borjac
Knowledge, Attitudes And Practices Regarding The Use Of Antibiotics: A Cross-Sectional Study From A Rural Area Of Lebanon, Carine Mounzer, Safaa Baydoun, Ranya Amer, Jamilah Borjac
BAU Journal - Health and Wellbeing
Despite the presence of a national policy restricting the easy access to antibiotics, irrational use of antibiotics continues to be widespread both in human use and livestock production in Lebanon. This study targets the general population in the rural region of Bekaa to assess their knowledge, attitudes and practices (KAP) towards antibiotic use. A cross sectional questionnaire was completed by 1151 participants, through face-to-face interviews. Study population was randomly selected. Descriptive statistics and correlation tests were applied in data analysis. 69.2% of participants had a very poor knowledge about antibiotics. More than 70% believed that viral infections may be treated …