Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2021

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 5491 - 5520 of 5571

Full-Text Articles in Entire DC Network

Covid-19 Prediction Using Lstm Algorithm: Gcc Case Study, Kareem Kamal A. Ghany, Hossam Zawbaa, Heba M. Sabri Jan 2021

Covid-19 Prediction Using Lstm Algorithm: Gcc Case Study, Kareem Kamal A. Ghany, Hossam Zawbaa, Heba M. Sabri

Articles

Coronavirus-19 (COVID-19) is the black swan of 2020. Still, the human response to restrain the virus is also creating massive ripples through different systems, such as health, economy, education, and tourism. This paper focuses on research and applying Artificial Intelligence (AI) algorithms to predict COVID-19 propagation using the available time-series data and study the effect of the quality of life, the number of tests performed, and the awareness of citizens on the virus in the Gulf Cooperation Council (GCC) countries at the Gulf area. So we focused on cases in the Kingdom of Saudi Arabia (KSA), United Arab of Emirates …


Antibiotic Development Incentives That Reflect Societal Value Of Antibiotics, Helen Boucher, Thomas M. File, Vance Fowler, Amanda Jezek, John Rex, Kevin Outterson Jan 2021

Antibiotic Development Incentives That Reflect Societal Value Of Antibiotics, Helen Boucher, Thomas M. File, Vance Fowler, Amanda Jezek, John Rex, Kevin Outterson

Faculty Scholarship

TO THE EDITOR—Rome and Kesselheim [1] claimed that rewarding developers of novel antibiotics with transferable exclusivity vouchers is an expensive approach to promoting antibiotic development. This analysis is incomplete as it focuses only on the cost of bringing new antibiotics to market without acknowledging their societal value. The authors also did not suggest an alternative approach. With patients running out of treatment options for resistant infections, failing to strengthen the antibiotic pipeline is not a reasonable option.


School Programming For Homelessness: Perspectives Of Families And Local Homeless Liaisons, Jazlynn J. Paige Jan 2021

School Programming For Homelessness: Perspectives Of Families And Local Homeless Liaisons, Jazlynn J. Paige

All-Inclusive List of Electronic Theses and Dissertations

Thisdissertation focuses on children experiencing homelessness and the effects homelessness has on their academic achievement from the perspective of the children, their parents, and local homeless liaisons. More importantly, this research explores what educators can do to create a positive, supportive, and stable environment at school for children experiencing homelessness by implementing an effective program or a number of support services. Data for the current study were gathered through phone and face-to-face interviews. The participants were 10 parent and child dyads living in a shelter and three school homeless liaisons. The semi-structured interviews focused on the resources, or lack thereof, …


An Outbreak Of Highly Pathogenic Avian Influenza (H7n7) In Australia And The Potential For Novel Influenza A Viruses To Emerge, Andrew T. Bisset, Gerard F. Hoyne Jan 2021

An Outbreak Of Highly Pathogenic Avian Influenza (H7n7) In Australia And The Potential For Novel Influenza A Viruses To Emerge, Andrew T. Bisset, Gerard F. Hoyne

Research outputs 2014 to 2021

In 2020, several geographically isolated farms in Victoria, Australia, experienced an outbreak of highly pathogenic avian influenza (HPAI) virus H7N7 and low pathogenic avian influenza (LPAI) viruses H5N2 and H7N6. Effective containment and control measures ensured the eradication of these viruses but the event culminated in substantial loss of livestock and significant economic impact. The avian HPAI H7N7 virus generally does not infect humans; however, evidence shows the ocular pathway presents a favourable tissue tropism for human infection. Through antigenic drift, mutations in the H7N7 viral genome may increase virulence and pathogenicity in humans. The Victorian outbreak also detected LPAI …


Impact Of Modern Antiviral Therapy Of Chronic Hepatitis B And C On Clinical Outcomes Of Liver Disease, Tiffany Khoo, Danielle Lam, John K. Olynyk Jan 2021

Impact Of Modern Antiviral Therapy Of Chronic Hepatitis B And C On Clinical Outcomes Of Liver Disease, Tiffany Khoo, Danielle Lam, John K. Olynyk

Research outputs 2014 to 2021

Chronic infections with the hepatitis B and C viruses have significant worldwide health and economic impacts. Previous treatments for hepatitis C such as interferon and ribavirin therapy were ineffective and poorly tolerated by patients. The introduction of directly acting curative antiviral therapy for hepatitis C and the wider use of nucleos(t)ide analogues for suppression of chronic Hepatitis B infection have resulted in many positive developments. Decreasing the prevalence of hepatitis B and C have concurrently reduced transmission rates and hence, the number of new infections. Antiviral treatments have decreased the rates of liver decompensation and as a result, lowered hospitalisation …


No Casual Relationship Between T2dm And The Risk Of Infectious Diseases: A Two-Sample Mendelian Randomization Study, Huachen Wang, Zheng Guo, Yulu Zheng, Chunyan Yu, Haifeng Hou, Bing Chen Jan 2021

No Casual Relationship Between T2dm And The Risk Of Infectious Diseases: A Two-Sample Mendelian Randomization Study, Huachen Wang, Zheng Guo, Yulu Zheng, Chunyan Yu, Haifeng Hou, Bing Chen

Research outputs 2014 to 2021

Background: In epidemiological studies, it has been proven that the occurrence of type 2 diabetes mellitus (T2DM) is related to an increased risk of infectious diseases. However, it is still unclear whether the relationship is casual. Methods: We employed a two-sample Mendelian randomization (MR) to clarify the causal effect of T2DM on high-frequency infectious diseases: sepsis, skin and soft tissue infections (SSTIs), urinary tract infections (UTIs), pneumonia, and genito-urinary infection (GUI) in pregnancy. And then, we analyzed the genome-wide association study (GWAS) meta-analysis of European-descent individuals and conducted T2DM-related single-nucleotide polymorphisms (SNPs) as instrumental variables (IVs) that were associated with …


Associations Between Genetic Variants In The Vitamin D Metabolism Pathway And Severity Of Covid-19 Among Uae Residents, Fatme Al-Anouti, Mira Mousa, Spyridon N. Karras, William B. Grant, Zainab Alhalwachi, Laila Abdel-Wareth, Maimunah Uddin, Nawal Alkaabi, Guan K. Tay, Bassam Mahboub, Habiba Alsafar Jan 2021

Associations Between Genetic Variants In The Vitamin D Metabolism Pathway And Severity Of Covid-19 Among Uae Residents, Fatme Al-Anouti, Mira Mousa, Spyridon N. Karras, William B. Grant, Zainab Alhalwachi, Laila Abdel-Wareth, Maimunah Uddin, Nawal Alkaabi, Guan K. Tay, Bassam Mahboub, Habiba Alsafar

Research outputs 2014 to 2021

Vitamin D has many effects on cells in the immune system. Many studies have linked low vitamin D status with severity of COVID-19. Genetic variants involved in vitamin D metabolism have been implicated as potential risk factors for severe COVID-19 outcomes. This study investigated how genetic variations in humans affected the clinical presentation of COVID-19. In total, 646 patients with SARS-CoV-2 infection were divided into two groups: noncritical COVID-19 (n = 453; 70.12%) and a critical group (n = 193; 29.87%). Genotype data on the GC, NADSYN1, VDR, and CYP2R1 genes along with data on serum 25-hydroxyvitamin D levels were …


Impact Of Coronavirus Disease 2019 (Covid-19) Outbreak Quarantine, Isolation, And Lockdown Policies On Mental Health And Suicide, Balasankar Ganesan, Adel Al-Jumaily, Kenneth N. K. Fong, Palak Prasad, Surendra Kumar Meena, Raymond Kai-Yu Tong Jan 2021

Impact Of Coronavirus Disease 2019 (Covid-19) Outbreak Quarantine, Isolation, And Lockdown Policies On Mental Health And Suicide, Balasankar Ganesan, Adel Al-Jumaily, Kenneth N. K. Fong, Palak Prasad, Surendra Kumar Meena, Raymond Kai-Yu Tong

Research outputs 2014 to 2021

The novel coronavirus disease (COVID-19) pandemic has made a huge impact on people's physical and mental health, and it remains a cause of death for many all over the world. To prevent the spread of coronavirus infection, different types of public health measures (social isolation, quarantine, lockdowns, and curfews) have been imposed by governments. However, mental health experts warn that the prolonged lockdown, quarantine, or isolation will create a “second pandemic” with severe mental health issues and suicides. The quarantined or isolated people may suffer from various issues such as physical inactivity, mental health, economic and social problems. As with …


The Missing Link Between Medical Science Knowledge And Public Awareness: Implications For Tourism And Hospitality Recovery After Covid-19, Jun Wen, Haifeng Hou, Metin Kozak, Fang Meng, Chung-En Yu, Wei Wang Jan 2021

The Missing Link Between Medical Science Knowledge And Public Awareness: Implications For Tourism And Hospitality Recovery After Covid-19, Jun Wen, Haifeng Hou, Metin Kozak, Fang Meng, Chung-En Yu, Wei Wang

Research outputs 2014 to 2021

Purpose: As the world grapples with the pervasive effects of the coronavirus pandemic, a notable disconnect has emerged in the public's understanding of scientific and medical research. Particularly, the travel industry has become unquestionably vulnerable amid the COVID-19 outbreak; this pandemic has interrupted the industry's operations with devastating economic consequences. This paper aims to highlight the importance of deconstructing barriers between medical science and public awareness related to COVID-19, taking tourism as a case in point. It also discusses the role of interdisciplinary research in facilitating the tourism and hospitality industry's recovery and alleviating tourists' uncertainties in the wake of …


Evolution, Ecology, And Zoonotic Transmission Of Betacoronaviruses: A Review, Herbert F. Jelinek, Mira Mousa, Eman Alefishat, Wael Osman, Ian Spence, Dengpan Bu, Samuel F. Feng, Jason Byrd, Paola A. Magni, Shafi Sahibzada, Guan K. Tay, Habiba S. Alsafar Jan 2021

Evolution, Ecology, And Zoonotic Transmission Of Betacoronaviruses: A Review, Herbert F. Jelinek, Mira Mousa, Eman Alefishat, Wael Osman, Ian Spence, Dengpan Bu, Samuel F. Feng, Jason Byrd, Paola A. Magni, Shafi Sahibzada, Guan K. Tay, Habiba S. Alsafar

Research outputs 2014 to 2021

Coronavirus infections have been a part of the animal kingdom for millennia. The difference emerging in the twenty-first century is that a greater number of novel coronaviruses are being discovered primarily due to more advanced technology and that a greater number can be transmitted to humans, either directly or via an intermediate host. This has a range of effects from annual infections that are mild to full-blown pandemics. This review compares the zoonotic potential and relationship between MERS, SARS-CoV, and SARS-CoV-2. The role of bats as possible host species and possible intermediate hosts including pangolins, civets, mink, birds, and other …


Glycosylation Of Igg Associates With Hypertension And Type 2 Diabetes Mellitus Comorbidity In The Chinese Muslim Ethnic Minorities And The Han Chinese, Xiaoni Meng, Manshu Song, Marija Vilaj, Jerko Štambuk, Mamatyusupu Dolikun, Jie Zhang, Di Liu, Hao Wang, Xiaoyu Zhang, Jinxia Zhang, Weijie Cao, Ana Momčilović, Irena Trbojević-Akmačić, Xingang Li, Deqiang Zheng, Lijuan Wu, Xiuhua Guo, Youxin Wang, Gordan Lauc, Wei Wang Jan 2021

Glycosylation Of Igg Associates With Hypertension And Type 2 Diabetes Mellitus Comorbidity In The Chinese Muslim Ethnic Minorities And The Han Chinese, Xiaoni Meng, Manshu Song, Marija Vilaj, Jerko Štambuk, Mamatyusupu Dolikun, Jie Zhang, Di Liu, Hao Wang, Xiaoyu Zhang, Jinxia Zhang, Weijie Cao, Ana Momčilović, Irena Trbojević-Akmačić, Xingang Li, Deqiang Zheng, Lijuan Wu, Xiuhua Guo, Youxin Wang, Gordan Lauc, Wei Wang

Research outputs 2014 to 2021

Objectives: Hypertension and type 2 diabetes mellitus comorbidity (HDC) is common, which confers a higher risk of cardiovascular disease than the presence of either condition alone. Describing the underlying glycomic changes of immunoglobulin G (IgG) that predispose individuals to HDC may help develop novel protective immune-targeted and anti-inflammatory therapies. Therefore, we investigated glycosylation changes of IgG associated with HDC. Methods: The IgG N-glycan profiles of 883 plasma samples from the three northwestern Chinese Muslim ethnic minorities and the Han Chinese were analyzed by ultra-performance liquid chromatography instrument. Results: We found that 12 and six IgG N-glycan traits showed significant associations …


Summary Of Aboriginal And Torres Strait Islander Health Status - Selected Topics 2020, Australian Indigenous Healthinfonet Jan 2021

Summary Of Aboriginal And Torres Strait Islander Health Status - Selected Topics 2020, Australian Indigenous Healthinfonet

Research outputs 2014 to 2021

The Summary of Aboriginal and Torres Strait Islander health status - selected topics 2020 is a useful source of the most recent national information for health workers and those studying in the field. It provides general information regarding the health status of Aboriginal and Torres Strait Islander people across the following topics:

  • social and cultural determinants
  • births and deaths
  • hospitalisations
  • chronic conditions (including CVD, cancer, diabetes and kidney health)
  • sexually transmitted infections
  • environmental health
  • social and emotional wellbeing
  • alcohol and other drug use.

The Summary is based on the Overview of Aboriginal and Torres Strait Islander health status 2020 and …


Change In Mental Health, Physical Health, And Social Relationships During Highly Restrictive Lockdown In The Covid-19 Pandemic: Evidence From Australia, Shane Rogers, Travis Miles Cruickshank Jan 2021

Change In Mental Health, Physical Health, And Social Relationships During Highly Restrictive Lockdown In The Covid-19 Pandemic: Evidence From Australia, Shane Rogers, Travis Miles Cruickshank

Research outputs 2014 to 2021

Background

A novel coronavirus first reported in Wuhan City in China in 2019 (COVID-19) developed into a global pandemic throughout 2020. Many countries around the world implemented strict social distancing policies to curb the spread of the virus. In this study we aimed to examine potential change in mental/physical health and social relationships during a highly restrictive COVID-19 lockdown period in Australia during April 2020.

Methods

Our survey (n = 1, 599) included questions about concerns, social behaviour, perceived change in relationship quality, social media use, frequency of exercise, physical health, and mental health during COVID-19 lockdown (April, 2020). …


Kynurenic Acid May Underlie Sex-Specific Immune Responses To Covid-19, Yuping Cai, Daniel J. Kim, Takehiro Takahashi, David I. Broadhurst, Hong Yan, Shuangge Ma, Nicholas J. W. Rattray, Arnau Casanovas-Massana, Benjamin Israelow, Jon Klein, Carolina Lucas, Tianyang Mao, Adam J. Moore, M. Catherine Muenker, Ji Eun Oh, Julio Silva, Patrick Wong, Albert I. Ko, Sajid A. Khan, Akiko Iwasaki, Caroline H. Johnson, Yale Impact Research Team Jan 2021

Kynurenic Acid May Underlie Sex-Specific Immune Responses To Covid-19, Yuping Cai, Daniel J. Kim, Takehiro Takahashi, David I. Broadhurst, Hong Yan, Shuangge Ma, Nicholas J. W. Rattray, Arnau Casanovas-Massana, Benjamin Israelow, Jon Klein, Carolina Lucas, Tianyang Mao, Adam J. Moore, M. Catherine Muenker, Ji Eun Oh, Julio Silva, Patrick Wong, Albert I. Ko, Sajid A. Khan, Akiko Iwasaki, Caroline H. Johnson, Yale Impact Research Team

Research outputs 2014 to 2021

Coronavirus disease 2019 (COVID-19) has poorer clinical outcomes in males than in females, and immune responses underlie these sex-related differences. Because immune responses are, in part, regulated by metabolites, we examined the serum metabolomes of COVID-19 patients. In male patients, kynurenic acid (KA) and a high KA–to–kynurenine (K) ratio (KA:K) positively correlated with age and with inflammatory cytokines and chemokines and negatively correlated with T cell responses. Males that clinically deteriorated had a higher KA:K than those that stabilized. KA inhibits glutamate release, and glutamate abundance was lower in patients that clinically deteriorated and correlated with immune responses. Analysis of …


Factors Driving The Compositional Diversity Of Apis Mellifera Bee Venom From A Corymbia Calophylla (Marri) Ecosystem, Southwestern Australia, Daniela Scaccabarozzi, Kenneth Dods, Thao T. Le, Joel P. A. Gummer, Michele Lussu, Lynne Milne, Tristan Campbell, Ben Pan Wafujian, Colin Priddis Jan 2021

Factors Driving The Compositional Diversity Of Apis Mellifera Bee Venom From A Corymbia Calophylla (Marri) Ecosystem, Southwestern Australia, Daniela Scaccabarozzi, Kenneth Dods, Thao T. Le, Joel P. A. Gummer, Michele Lussu, Lynne Milne, Tristan Campbell, Ben Pan Wafujian, Colin Priddis

Research outputs 2014 to 2021

Bee venom (BV) is the most valuable product harvested from honeybees ($30 - $300 USD per gram) but marginally produced in apiculture. Though widely studied and used in alternative medicine, recent efforts in BV research have focused on its therapeutic and cosmetic applications, for the treatment of degenerative and infectious diseases. The protein and peptide composition of BV is integral to its bioactivity, yet little research has investigated the ecological factors influencing the qualitative and quantitative variations in the BV composition. Bee venom from Apis mellifera ligustica (Apidae), collected over one flowering season of Corymbia calophylla (Myrtaceae; marri) was characterized …


Putative Factors Influencing Knowledge And Behavioural Practices Of Health Science Undergraduate Students Towards Covid-19 Infection Ahead Of Re-Opening Universities In Ghana, Emmanuel Acheampong, Evans Asamoah Adu, Enoch O. Anto, Yaa Obirikorang, Eric Adua, Sylvester Yao Lopko, Emmanuella Nsenbah Acheampong, Agartha Odame Anto, Vivian Baah, Christian Obirikorang Jan 2021

Putative Factors Influencing Knowledge And Behavioural Practices Of Health Science Undergraduate Students Towards Covid-19 Infection Ahead Of Re-Opening Universities In Ghana, Emmanuel Acheampong, Evans Asamoah Adu, Enoch O. Anto, Yaa Obirikorang, Eric Adua, Sylvester Yao Lopko, Emmanuella Nsenbah Acheampong, Agartha Odame Anto, Vivian Baah, Christian Obirikorang

Research outputs 2014 to 2021

Background: The coronavirus disease 2019 (COVID-19) virus is a global pandemic affecting daily activities and delaying the reopening of several institutions such as universities. As a result, precautionary and preventive measures are being implemented to curtail the spread of the virus. However, knowledge and compliance measures are essential for adequate preparedness to reopen the universities amidst the pandemic. Methods: This cross-sectional study evaluated knowledge, attitudes, and practices (KAP) along with factors influencing Health Science undergraduate students toward the COVID-19 infection pandemic in Ghana. A total of 606 students provided information regarding KAP of COVID-19 infection using an online questionnaire designed …


Major Genetic Discontinuity And Novel Toxigenic Species In Clostridioides Difficile Taxonomy, Daniel R. Knight, Korakrit Imwattana, Brian Kullin, Enzo Guerrero-Araya, Daniel Paredes-Sabja, Xavier Didelot, Kate E. Dingle, David W. Eyre, César Rodríguez, Thomas V. Riley Jan 2021

Major Genetic Discontinuity And Novel Toxigenic Species In Clostridioides Difficile Taxonomy, Daniel R. Knight, Korakrit Imwattana, Brian Kullin, Enzo Guerrero-Araya, Daniel Paredes-Sabja, Xavier Didelot, Kate E. Dingle, David W. Eyre, César Rodríguez, Thomas V. Riley

Research outputs 2014 to 2021

Clostridioides difficile infection (CDI) remains an urgent global One Health threat. The genetic heterogeneity seen across C. difficile underscores its wide ecological versatility and has driven the significant changes in CDI epidemiology seen in the last 20 years. We analysed an international collection of over 12,000 C. difficile genomes spanning the eight currently defined phylogenetic clades. Through whole-genome average nucleotide identity, and pangenomic and Bayesian analyses, we identified major taxonomic incoherence with clear species boundaries for each of the recently described cryptic clades CI–III. The emergence of these three novel genomospecies predates clades C1–5 by millions of years, rewriting the …


Gut Microbiota Interplay With Covid-19 Reveals Links To Host Lipid Metabolism Among Middle Eastern Populations, Mohammad Tahseen Al Bataineh, Andreas Henschel, Mira Mousa, Marianne Daou, Fathimathuz Waasia, Hussein Kannout, Mariam Khalili, Mohd Azzam Kayasseh, Abdulmajeed Alkhajeh, Maimunah Uddin, Nawal Alkaabi, Guan K. Tay, Samuel F. Feng, Ahmed F. Yousef, Habiba S. Alsafar, Uae Covid-19 Collaborative Partnership Jan 2021

Gut Microbiota Interplay With Covid-19 Reveals Links To Host Lipid Metabolism Among Middle Eastern Populations, Mohammad Tahseen Al Bataineh, Andreas Henschel, Mira Mousa, Marianne Daou, Fathimathuz Waasia, Hussein Kannout, Mariam Khalili, Mohd Azzam Kayasseh, Abdulmajeed Alkhajeh, Maimunah Uddin, Nawal Alkaabi, Guan K. Tay, Samuel F. Feng, Ahmed F. Yousef, Habiba S. Alsafar, Uae Covid-19 Collaborative Partnership

Research outputs 2014 to 2021

The interplay between the compositional changes in the gastrointestinal microbiome, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and severity, and host functions is complex and yet to be fully understood. This study performed 16S rRNA gene-based microbial profiling of 143 subjects. We observed structural and compositional alterations in the gut microbiota of the SARS-CoV-2-infected group in comparison to non-infected controls. The gut microbiota composition of the SARS-CoV-2-infected individuals showed an increase in anti-inflammatory bacteria such as Faecalibacterium (p-value = 1.72 × 10–6) and Bacteroides (p-value = 5.67 × 10–8). We also revealed a higher relative abundance of the highly …


The Effect Of The Covid-19 Vaccine On Daily Cases And Deaths Based On Global Vaccine Data, Zhiwei Li, Xiangtong Liu, Mengyang Liu, Zhiyuan Wu, Yue Liu, Weiming Li, Mengmeng Liu, Xiaonan Wang, Bo Gao, Yanxia Luo, Xia Li, Lixin Tao, Wei Wang, Xiuhua Guo Jan 2021

The Effect Of The Covid-19 Vaccine On Daily Cases And Deaths Based On Global Vaccine Data, Zhiwei Li, Xiangtong Liu, Mengyang Liu, Zhiyuan Wu, Yue Liu, Weiming Li, Mengmeng Liu, Xiaonan Wang, Bo Gao, Yanxia Luo, Xia Li, Lixin Tao, Wei Wang, Xiuhua Guo

Research outputs 2014 to 2021

Background: Coronavirus disease 2019 (COVID-19), a global pandemic, has caused over 216 million cases and 4.50 million deaths as of 30 August 2021. Vaccines can be regarded as one of the most powerful weapons to eliminate the pandemic, but the impact of vaccines on daily COVID-19 cases and deaths by country is unclear. This study aimed to investigate the correlation between vaccines and daily newly confirmed cases and deaths of COVID-19 in each country worldwide. Methods: Daily data on firstly vaccinated people, fully vaccinated people, new cases and new deaths of COVID-19 were collected from 187 countries. First, we used …


A Survey To Evaluate The Association Of Covid-19 Restrictions On Perceived Mood And Coping In Australian Community Level Athletes, Caitlin Fox-Harding, Sarah A. Harris, Shane L. Rogers, Shayne Vial, Philipp Beranek, Mitchell Turner, Travis Cruickshank Jan 2021

A Survey To Evaluate The Association Of Covid-19 Restrictions On Perceived Mood And Coping In Australian Community Level Athletes, Caitlin Fox-Harding, Sarah A. Harris, Shane L. Rogers, Shayne Vial, Philipp Beranek, Mitchell Turner, Travis Cruickshank

Research outputs 2014 to 2021

Australian community level athletes faced unprecedented changes to their training andcompetition options as the global COVID-19 pandemic took a stronghold. This disruptionwas predicted to have a negative impact on emotional well-being as communitiesbraced through periods of social isolation and physical distancing requirements. Thisstudy provides an Australian perspective on the emotional well-being of communitylevel athletes and the extent to which they coped during the COVID-19 pandemic.Emotional well-being and coping were measured using the Brief Emotional ExperienceScale and the 28-item Brief Cope Scale. Both instruments were administered alongwith other questions pertaining to participant demographics and training status via anonline survey between April …


The Role Of C-Reactive Protein And Fibrinogen In The Development Of Intracerebral Hemorrhage: A Mendelian Randomization Study In European Population, Biyan Wang, Xiaoyu Zhang, Di Liu, Jie Zhang, Mingyang Cao, Xin Tian, Isinta E. Maranga, Xiaoni Meng, Qiuyue Tian, Feifei Tian, Weijie Cao, Wei Wang, Manshu Song, Youxin Wang Jan 2021

The Role Of C-Reactive Protein And Fibrinogen In The Development Of Intracerebral Hemorrhage: A Mendelian Randomization Study In European Population, Biyan Wang, Xiaoyu Zhang, Di Liu, Jie Zhang, Mingyang Cao, Xin Tian, Isinta E. Maranga, Xiaoni Meng, Qiuyue Tian, Feifei Tian, Weijie Cao, Wei Wang, Manshu Song, Youxin Wang

Research outputs 2014 to 2021

Background: The causal association of C-reactive protein (CRP) and fibrinogen on intracerebral hemorrhage (ICH) remains uncertain. We investigated the causal associations of CRP and fibrinogen with ICH using two-sample Mendelian randomization. Method: We used single-nucleotide polymorphisms associated with CRP and fibrinogen as instrumental variables. The summary data on ICH were obtained from the International Stroke Genetics Consortium (1,545 cases and 1,481 controls). Two-sample Mendelian randomization estimates were performed to assess with inverse-variance weighted and sensitive analyses methods including the weighted median, the penalized weighted median, pleiotropy residual sum and outlier (MR-PRESSO) approaches. MR-Egger regression was used to explore the pleiotropy. …


Risk Factors For Covid-19 Infection, Disease Severity And Related Deaths In Africa: A Systematic Review, Hailay Abrha Gesesew, Digsu Negese Koye, Dagnachew Muluye Fetene, Mulu Woldegiorgis, Yohannes Kinfu, Ayele Bali Geleto, Yohannes Adama Melaku, Hassen Mohammed, Kefyalew Addis Alene, Mamaru Ayenew Awoke, Mulugeta Molla Birhanu, Amanuel Tesfay Gebremedhin, Yalemzewod Assefa Gelaw, Desalegn Markos Shifti, Muluken Dessalegn Muluneh, Teketo Kassaw Tegegne, Solomon Abrha, Atsede Fantahun Aregay, Mohammed Biset Ayalew, Abadi Kahsu Gebre, Kidane Tadesse Gebremariam, Tesfaye Gebremedhin, Lemlem Gebremichael, Cheru Tesema Leshargie, Getiye Dejenu Kibret, Maereg Wagnew Meazaw, Alemayehu Berhane Mekonnen, Dejen Y. Tekle, Azeb G. Tesema, Fisaha H. Tesfay, Wubshet Tesfaye, Befikadu L. Wubishet, Berihun A. Dachew, Akilew A. Adane Jan 2021

Risk Factors For Covid-19 Infection, Disease Severity And Related Deaths In Africa: A Systematic Review, Hailay Abrha Gesesew, Digsu Negese Koye, Dagnachew Muluye Fetene, Mulu Woldegiorgis, Yohannes Kinfu, Ayele Bali Geleto, Yohannes Adama Melaku, Hassen Mohammed, Kefyalew Addis Alene, Mamaru Ayenew Awoke, Mulugeta Molla Birhanu, Amanuel Tesfay Gebremedhin, Yalemzewod Assefa Gelaw, Desalegn Markos Shifti, Muluken Dessalegn Muluneh, Teketo Kassaw Tegegne, Solomon Abrha, Atsede Fantahun Aregay, Mohammed Biset Ayalew, Abadi Kahsu Gebre, Kidane Tadesse Gebremariam, Tesfaye Gebremedhin, Lemlem Gebremichael, Cheru Tesema Leshargie, Getiye Dejenu Kibret, Maereg Wagnew Meazaw, Alemayehu Berhane Mekonnen, Dejen Y. Tekle, Azeb G. Tesema, Fisaha H. Tesfay, Wubshet Tesfaye, Befikadu L. Wubishet, Berihun A. Dachew, Akilew A. Adane

Research outputs 2014 to 2021

© BMJ Publishing Group Limited 2020. Objective The aim of this study was to provide a comprehensive evidence on risk factors for transmission, disease severity and COVID-19 related deaths in Africa. Design A systematic review has been conducted to synthesise existing evidence on risk factors affecting COVID-19 outcomes across Africa. Data sources Data were systematically searched from MEDLINE, Scopus, MedRxiv and BioRxiv. Eligibility criteria Studies for review were included if they were published in English and reported at least one risk factor and/or one health outcome. We included all relevant literature published up until 11 August 2020. Data extraction and …


Evaluation Of The Antimicrobial Activity Of Ridinilazole And Six Comparators Against Chinese, Japanese And South Korean Strains Of Clostridioides Difficile, Deirdre A. Collins, Yuan Wu, Kazuhiro Tateda, Hee Jung Kim, Richard J. Vickers, Thomas V. Riley Jan 2021

Evaluation Of The Antimicrobial Activity Of Ridinilazole And Six Comparators Against Chinese, Japanese And South Korean Strains Of Clostridioides Difficile, Deirdre A. Collins, Yuan Wu, Kazuhiro Tateda, Hee Jung Kim, Richard J. Vickers, Thomas V. Riley

Research outputs 2014 to 2021

BACKGROUND: Clostridioides difficile is the most common cause of antimicrobial-associated diarrhoea in high-income countries. Fluoroquinolone resistance enabled the emergence and intercontinental spread of the epidemic ribotype (RT) 027 strain of C. difficile in the early 2000s. Despite frequent inappropriate antimicrobial use in Asia, RT 027 is rarely isolated in the region, but the often fluoroquinolone- and clindamycin-resistant RT 017 strain predominates. OBJECTIVES: This study evaluated the antimicrobial activity of ridinilazole, a novel antimicrobial agent with highly specific activity for C. difficile, against clinical strains of C. difficile from Asia. METHODS: C. difficile strains from Japan (n = 64), South Korea …


Detect Schools Study Protocol: A Prospective Observational Cohort Surveillance Study Investigating The Impact Of Covid-19 In Western Australian Schools, Marianne J. Mullane, Hannah M. Thomas, Melanie Epstein, Joelie Mandzufas, Narelle Mullan, Alexandra Whelan, Karen Lombardi, Tina Barrow, Sherlynn Ang, Adele Leahy, Ewan Cameron, Leanne Lester, Matt Cooper, Paul Stevenson, Mitch Hartman, Anne Mckenzie, Francis Mitrou, Stephen R. Zubrick, Juli Coffin, Donna Cross, Asha C. Bowen, Peter Gething Jan 2021

Detect Schools Study Protocol: A Prospective Observational Cohort Surveillance Study Investigating The Impact Of Covid-19 In Western Australian Schools, Marianne J. Mullane, Hannah M. Thomas, Melanie Epstein, Joelie Mandzufas, Narelle Mullan, Alexandra Whelan, Karen Lombardi, Tina Barrow, Sherlynn Ang, Adele Leahy, Ewan Cameron, Leanne Lester, Matt Cooper, Paul Stevenson, Mitch Hartman, Anne Mckenzie, Francis Mitrou, Stephen R. Zubrick, Juli Coffin, Donna Cross, Asha C. Bowen, Peter Gething

Research outputs 2014 to 2021

Introduction: Amidst the evolving COVID-19 pandemic, understanding the transmission dynamics of the SARS-CoV-2 virus is key to providing peace of mind for the community and informing policy-making decisions. While available data suggest that school-aged children are not significant spreaders of SARS-CoV-2, the possibility of transmission in schools remains an ongoing concern, especially among an aging teaching workforce. Even in low-prevalence settings, communities must balance the potential risk of transmission with the need for students' ongoing education. Through the roll out of high-throughput school-based SARS-CoV-2 testing, enhanced follow-up for individuals exposed to COVID-19 and wellbeing surveys, this study investigates the dynamics …


Antibacterial R & D At A Crossroads: We’Ve Pushed As Hard As We Can...Now We Need To Start Pulling!, John H. Rex, Kevin Outterson Jan 2021

Antibacterial R & D At A Crossroads: We’Ve Pushed As Hard As We Can...Now We Need To Start Pulling!, John H. Rex, Kevin Outterson

Faculty Scholarship

In this issue of Clinical Infectious Diseases, Dheman et al [1] present an analysis by experts at the US Food and Drug Administration (FDA) of trends in antibacterial clinical development over the past 4 decades. By turns instructive and disturbing, this 40-year perspective provides insight into the impact of efforts to restore the antibacterial pipeline.

As a preview, the key messages from Dheman et al are all bad news for public health: (1) the number of new antibacterials in clinical development is (again) falling, (2) the risk of failure is rising, (3) the speed of clinical development …


The Covid-19 Vaccine Race: Intellectual Property, Collaoration(S), Nationalism And Misinformation, Ana Santos Rutschman Jan 2021

The Covid-19 Vaccine Race: Intellectual Property, Collaoration(S), Nationalism And Misinformation, Ana Santos Rutschman

Faculty Publications

The COVID-19 pandemic has brought a national and global vaccine race. This Article examines the race with respect to contemporary frameworks for biopharmaceutical research and development. Specifically, this Article focuses on the effect of patents, pre-production agreements, public-private partnerships, and vaccine misinformation. This Article analyzes lessons learned from the COVID-19 pandemic, advocates for promoting vaccine affordability and equity, and suggests modifications to existing preparedness frameworks to prepare for upcoming outbreaks of infectious disease.


Othering Across Borders, Steven Arrigg Koh Jan 2021

Othering Across Borders, Steven Arrigg Koh

Faculty Scholarship

Our contemporary moment of reckoning presents an opportunity to evaluate racial subordination and structural inequality throughout our three-tiered domestic, transnational, and international criminal law system. In particular, this Essay exposes a pernicious racial dynamic in contemporary U.S. global criminal justice policy, which I call othering across borders. First, this othering may occur when race emboldens political and prosecutorial actors to prosecute foreign defendants. Second, racial animus may undermine U.S. engagement with international criminal legal institutions, specifically the International Criminal Court. This Essay concludes with measures to mitigate such othering.


Impact Of Historical Review And Archival Accessibility In Combating Covid-19 Pandemic In Nigeria, Bakare D. Oluwabunmi Dr, Mary Funke Ajayi Mrs Jan 2021

Impact Of Historical Review And Archival Accessibility In Combating Covid-19 Pandemic In Nigeria, Bakare D. Oluwabunmi Dr, Mary Funke Ajayi Mrs

Library Philosophy and Practice (e-journal)

Archives and records management play a central role in understanding the past and aid effective decision-making on current situations. The main objective of this study was to assess the impact of historical review and archival accessibility in combating COVID-19 pandemic in Nigeria. The study was based on a systematic review of existing literature on overview of pandemics in human history, history of pandemic in Nigeria, 1918-1919 influenza in Nigeria, COVID-19 pandemic in Nigeria, and archival accessibility and pandemics. The study was able to identify some major challenges of archival accessibility in Nigeria, which made it difficult to access documents of …


Investigating How Timing Of Case Study Presentation On Huntington Disease Influences Construction Of Argument Warrant While Learning The Central Dogma Of Molecular Biology, Katherine A. Sharp Jan 2021

Investigating How Timing Of Case Study Presentation On Huntington Disease Influences Construction Of Argument Warrant While Learning The Central Dogma Of Molecular Biology, Katherine A. Sharp

Theses and Dissertations--Education Sciences

A common belief among pre-medical and medical students is that biochemistry is not relevant to practicing medicine. Among topics commonly taught in biochemistry, courses include the Central Dogma of Molecular Biology, which is among the most critical science topics taught to medical students by biochemistry educators. Perceived irrelevance among students may be due to common curricular trends in biochemistry education. Many biochemistry courses are found at Research I (R1) universities that teach biochemistry using traditional lectures with little evidence of supporting learning with real-world applications. Instructors commonly assume that students can make realworld connections independently during lecture courses, but it …


Text Mining To Identify The Origin Of Chronic Wasting Disease, G. Webb Jan 2021

Text Mining To Identify The Origin Of Chronic Wasting Disease, G. Webb

Faculty Research, Scholarly, and Creative Activity

Chronic wasting  disease (CWD)  is  a 100  percent  fatal,  prion  disease of  deer  that  has  the potential  to decimate  the  deer  population and  jump to  the  human  population.   A  simple  Google  search on  the  “origin of  chronic wasting  disease” yielded  a total  of  56  relevant  articles.   Of  these,  75  percent  report  that  the origin  is  unknown,  19.6  percent  report  that  the  disease  may  have  originated  in  a  Fort  Collins,  Colorado, government  research facility, and 5.4 percent  report  other  possible  origins.  Government  sources  reported the  Fort  Collins  theory  4.3 percent  of  the  time  while  non-governmental  sources,  such  as news articles, reported …