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Feminist Abolitionist Nursing, Martha Paynter, Keisha Jefferies, Leah Carrier, Lorie Goshin

Publications and Research

The converging crises of COVID-19 and racist state violence in 2020 shifted public discourse about marginalization, public health, and racism in unprecedented ways. Nursing responded to the pandemic with heroic commitment and new politicization. But public engagement with systemic racism is forcing a reckoning in nursing. The profession has its own history of racism and of alliance with systems of state control with which to contend. In this article, we argue nursing must adopt an ethics of abolitionism to realize its goals for health and justice. Abolitionism theorizes that policing and prison systems, originating from systems of enslavement and colonial …

Exported Plasmodial J Domain Protein, Pfe0055c, And Pfhsp70-X Form A Specific Co-Chaperone-Chaperone Partnership, Tanima Dutta, Harpreet Singh, Jason E. Gestwicki, Gregory L. Blatch

Medical Papers and Journal Articles

Plasmodium falciparum is a unicellular protozoan parasite and causative agent of a severe form of malaria in humans, accounting for very high worldwide fatality rates. At the molecular level, survival of the parasite within the human host is mediated by P. falciparum heat shock proteins (PfHsps) that provide protection during febrile episodes. The ATP-dependent chaperone activity of Hsp70 relies on the co-chaperone J domain protein (JDP), with which it forms a chaperone-co-chaperone complex. The exported P. falciparum JDP (PfJDP), PFA0660w, has been shown to stimulate the ATPase activity of the exported chaperone, PfHsp70-x. Furthermore, PFA0660w has been shown to associate …

Covid-19 And The Workplace: Implications, Issues, And Insights For Future Research And Action, Kevin M. Kniffin, Jayanth Narayanan, Frederik Anseel, John Antonakis, Susan P. Ashford, Arnold B. Bakker, Peter Bamberger, Hari Bapuji, Devasheesh P. Bhave, Virginia K. Choi, Stefanie J. Creary, Evangelia Demerouti, Francis J. Flynn, Michele J. Gelfand, Lindred L. Greer, Gary Johns, Selin Kesebir, Peter G. Klein, Sun Young Lee, Hakan Ozcelik, Jennifer Louise Petriglieri, Nancy P. Rothbard, Cort W. Rudolph, Jason D. Shaw, Nina Sirola

Research Collection Lee Kong Chian School Of Business

COVID-19’s impacts on workers and workplaces across the globe have been dramatic. We present a broad review of prior research rooted in work and organizational psychology, and related fields, for making sense of the implications for employees, teams, and work organizations. Our review and preview of relevant literatures focuses on: (i) emerging changes in work practices (e.g., working from home, virtual teams) and (ii) economic and social psychological impacts (e.g, unemployment, mental well-being). In addition, we examine the potential moderating factors of age, race and ethnicity, gender, family status, personality, andcultural differences to generate disparate effects. Illustrating the benefits of …

An Overview Of Antimicrobial Compounds From African Edible Insects And Their Associated Microbiota, Cynthia M. Mudalungu, Chrysantus M. Tanga, Segenet Kelemu, Baldwyn Torto

All Peer-Reviewed Publications

The need for easily biodegradable and less toxic chemicals in drug development and pest control continues to fuel the exploration and discovery of new natural molecules. Like certain plants, some insects can also respond rapidly to microbial infections by producing a plethora of immune-induced molecules that include antibacterial and antifungal peptides/polypeptides (AMPs), among other structurally diverse small molecules. The recent recognition that new natural product-derived scaffolds are urgently needed to tackle life-threatening pathogenic infections has been prompted by the health threats posed by multidrug resistance. Although many researchers have concentrated on the discovery of AMPs, surprisingly, edible insect-produced AMPs/small molecules …

Cloaca Palace, Connor Marie Stankard

Theses and Dissertations

In this thesis, I trace the compulsive fear of holes, known as trypophobia, from an uncontrollable obsession to a pleasurable preoccupation. The body’s physical porousness makes us receptive to our surroundings, allowing external matter in and destabilizing the boundaries of self and other. Matter invades us, encoding itself into our DNA and transforming humans into chimeric creatures.

Through paintings and multi-media installations, I encourage viewers to reflect on their own bodies as a series of holes, vulnerable receptors to the world. I use the figure of a woman to personify a human hole which has been infected by the outside, …

The Role Of Insurance Coverage In Outpatient Substance Use Disorder Treatment Referral, Utilization, And Outcomes, Huyen Pham

Theses and Dissertations

Opioid-related overdoses increased dramatically in recent years. Medicaid plays a predominant role in paying for opioid use disorder (OUD) treatment. However, there is a critical gap in understanding the role of Medicaid coverage in referrals to treatment, treatment utilization, and treatment retention. The three studies used observational and quasi-experimental (i.e., natural experiment) designs leveraging state and year variation in Medicaid expansion to characterize the role of Medicaid coverage in OUD treatment. We found that individuals with OUD with Medicaid insurance were more likely to use outpatient treatment, whereas those who were uninsured were more likely to use self-help groups only. …

Identifying Genes Downstream Of Mef2 That Influence Ethanol Sedation In Drosophila Melanogaster, Ananya Talikoti

Theses and Dissertations

Alcohol use disorder is a global public health issue that affects millions across the world. It can result in negative physical and mental health outcomes, and currently treatment options are limited and rates of relapse are high. Identifying genes that affect aspects of ethanol behaviors in model organisms, such as Drosophila melanogaster, can serve to eventually develop more robust therapeutic interventions for those experiencing alcohol dependence. Previous studies have identified a relationship between a person's initial sensitivity to alcohol and their abuse potential for the drug in later life. Therefore, we can study sedation behaviors in Drosophila melanogaster to …

Impact Of Physical Activity And Cardiorespiratory Fitness On Vascular Homeostasis In Premenopausal Women Consuming A Westernized High-Fat Meal, Lauren N. Pedersen

Theses and Dissertations

A large percentage of adults in industrialized nations consume a Westernized dietary pattern, which contributes to fasting dyslipidemia and increased risk for atherosclerotic cardiovascular disease. Evidence suggests that a single Westernized meal containing high saturated fat may induce alterations in blood lipids as well as disturb multiple factors regulating peripheral vascular homeostasis, including innate immune cell function, oxidative stress, and vascular function. Conversely, participation in acute and chronic exercise may beneficially impact an individual’s postprandial response. Therefore, this dissertation contains three manuscripts seeking to describe how acute exercise, cardiorespiratory fitness, and physical activity level impact the lipemic and vascular homeostatic …

Characterization Of Cytochrome P450 3a4 Structure And Ligand Binding Mechanism In Anionic Nanodiscs, David T. Sweeney

Theses and Dissertations

The Cytochromes P450 superfamily are ubiquitous throughout life and are present in some viruses. Humans encode for 57 of these enzymes that are involved in the metabolism of ~90% of all chemicals. These membrane-bound monooxygenase enzymes utilize a heme protoporphyrin at their active site to activate molecular oxygen and oxidize their substrates through an intermediate deemed nature's most powerful oxidizer. They are a powerful system at our disposal yet understanding of their structure and ligand binding mechanisms in the presence of a lipid bilayer remains poorly understood. The focus of this work is on Cytochrome P450 3A4 (CYP3A4). We set …

Patient Blood Management Programs And Their Association With Patient And Organizational Outcomes, Sandra L. Lamm

Theses and Dissertations

Blood transfusions are the most common hospital procedure. However, many transfusions may be unnecessary. These unnecessary transfusion may expose patients to the potential risks of transfusion without improving patient outcomes Patient blood management (PBM) programs emphasize conserving a patient’s own blood resources and only transfusing the minimum amount needed. This study examined the organizational and environmental factors associated with a hospital having a PBM program, or having processes based on PBM, and their impact on organizational and patient outcomes potentially affected by blood transfusions.

A PBM survey was created for this study and used to gather information on hospitals having …

Associations Between Social Determinants Of Health And Chlamydia Infections Among Georgia Counties, Bre'auna K. Beasley

Theses and Dissertations

Chlamydia is a growing public health concern that disproportionately impacts southern states. While social determinants of health are not direct causes of chlamydia infections, studies have found that these determinants do influence infections by creating environments that promote or hinder health seeking behaviors, as well as exposure to risk factors. Guided by the Social Ecological Model of Public Health and the Healthy People 2030 Social Determinants of Health Conceptual Framework, this dissertation study aimed to examine the associations between social determinants of health and chlamydia infections among Georgia counties. This study employed a correlational research design. Aggregate-level secondary data for …

Examining The Effect Of Item-Writing Flaws On The Psychometric Parameters Of Pharmacy Therapeutics Examinations, Veronica P. Shuford

Theses and Dissertations

Colleges and schools of pharmacy (C/SOP) use direct measures of assessment to provide evidence of student learning, with multiple-choice questions (MCQs) being one the most common formats used in health sciences education to assess students’ knowledge, skills, and abilities (Pate & Caldwell, 2014). This study examined the occurrence of item-writing flaws (IWFs) in the Clinical Therapeutics Module (CTM) sequence of courses at a college of pharmacy at an academic health center in the southeastern United States. The goals of the study were to: (1) identify the most common item-writing flaws on examinations in the CTM sequence of courses, (2) determine …

Feeling The Squeeze: The Association Between Multigeneration Caregiving And Informal Caregivers’ Health, Christine L. Patterson

Theses and Dissertations

While U.S. public policy and research has focused on the health needs of the aging population, less attention has been given to the consequences informal caregivers face caring for this generation. With the segment of the population aged 65 years or older growing rapidly, it is important to understand the factors that place informal caregivers at risk for poor health outcomes and health behaviors. Since multigeneration caregivers balance more personal, work, and caregiving demands than single-generation informal caregivers of older adults, they may be at higher risk for poor health outcomes. The aim of this study was to examine the …

Il-36g Cytokine Induction In Oral Epithelial Cells Triggered By Treponema Denticola And Their Role In Chronic Periodontitis, Christopher Blake

Theses and Dissertations

Periodontal disease is a polymicrobial disease affecting 10-15% of the population. Periodontal disease affects the quality of life by reducing mastication and potentially causing tooth loss. Periodontal disease is also linked to more severe, systemic diseases such as cardiovascular disease and rheumatoid arthritis. Development of the diseased state occurs when the plaque biofilm shifts from healthy to dysbiotic. The shift to a dysbiotic biome brings with it a shift in bacterial presence, specifically an increase in gram-negative bacteria, such as T. denticola. T. denticola is a gram-negative, anaerobic spirochete whose relationship with oral epithelial cells is poorly understood. Preliminary data …

Pushing The Limits: Increasing The Speed And Specificity Of Sars-Cov-2 Testing, Grayson Way

Theses and Dissertations

The prevalence and spread of the current COVID-19 pandemic have highlighted the importance of continual improvements upon current microbiological testing methods. Rapid and accurate testing can help mitigate spread by improving on the time to quarantine and quarantine duration required. As of the writing of this thesis, COVID-19 has been responsible for more than 500,000 deaths in the United States of America, and greater than 2 million deaths globally. The work done in this thesis has shown improvements in the current SARS-CoV-2 testing methodology by reducing the time it takes for patient testing while maintaining accuracy and the sensitivity required …

A Pilot Study Of Oral Health Related Quality Of Life During Gynecologic Cancer Treatment, Stephanie Kushnir

EWU Masters Thesis Collection

Purpose: The purpose of this study was to determine if oral health education increases oral health related quality of life in gynecologic oncology patients.

Methods: In this pilot study, 23 participants (18 - 70+ years) with a history of gynecologic cancer were recruited to participate in the study. Participants completed an Oral Health Impact Profile (OHIP-14) questionnaire prior to and after given education packet.

Results: At baseline, the mean pre-test OHIP-14 score was 6.7 (SD 8.4) and mean OHIP-14 post-test score was 8.8 (SD 8.4). Pearson Correlation was .90. P (T< = t) one-tail p < .008. Demonstrating statistical significance.

Conclusion: OHIP-14 scores increased after four-weeks, higher scores of …

Review Of Suspect Communities: Anti-Muslim Racism And The Domestic War On Terror, Louise Cainkar

Social and Cultural Sciences Faculty Research and Publications

No abstract provided.

Detection Of Rhodococcus Equi By Pcr From Foals And Determination Of Antimicrobial Susceptibility, Şükrü Kirkan, Uğur Parin, Hafi̇ze Tuğba Yüksel Dolgun, Eli̇f Oya Oral

Turkish Journal of Veterinary & Animal Sciences

The scope of this research was determination of Rhodococcus equi isolates and antimicrobial susceptibilities in nasal swab specimen taken from animals between 0 and 6 months of age period. R. equi was identified from 10 isolates (11.1%) by automatic identification device. The verification of isolates were conducted by 16S ribosomal RNA PCR. VapA gene presence was detected in two (20%) isolates and multidrug resistance was identified against 11 antimicrobials. The antimicrobial resistance to macrolides and rifampin is arising worldwide since the excessive usage of the chemotherapeutics in various breeding farms just by evaluating monitoring outcomes. These results exhibit the presence …

Failure Of Passive Transfer In Neonatal Calves In Dairy Farms In Ankara Region, Erdal Kara, Ebubeki̇r Ceylan

Turkish Journal of Veterinary & Animal Sciences

This study, as a model for the farms in Turkey implementing professional herd management protocols, was conducted to examine a variety of factors in relation to the prevalence of failure of passive transfer (FPT) and the passive transfer (PT) in dairy farms in Ankara. A total of 400 calves and 363 cows from 9 different farms practicing professional herd management systems and employ full-time veterinarians were included in the study. Following the birth of the calf, colostrum was taken from cows, blood samples were taken from calves at 24-48 h of age and analysed for IgG using ELISA. FPT was …

Evaluation Of Survival Rate Of Fogera Calves And Their Crossbred At Chagni Cattle Breed Improvement And Andasa Livestock Research Centres, Tazeb Gessess, Godadaw Misganaw, Yohannes Dagnew

Turkish Journal of Veterinary & Animal Sciences

The study was conducted in Chagni Cattle Bred Improvement and Andassa Livestock Research Center of Western, Amhara region to evaluate the survival rate of pure Fogera and their HolsteinFriesian crossbred calves. A retrospective type of study design was used for conducting the study. The data used in the study was taken from the records of Chagni ranch and Andassa Livestock Research Center between 2011 and 2017. The survival rates were estimated by using cox regression and Kaplan-Meier model of Stata software. The mortality rate was 3% which was nearly the optimum level that many scholars agreed for successful rearing practices. …

Seroprevalence Of Bovine Viral Diarrhoea Virus, Bovine Herpesvirus Type 1 And Bovineherpesvirus Type 4 Infections In Cattle In Ağrı Province, Eastern Anatolia Region, Turkey, Mustafa Si̇nan Aktaş, Hasan Çeli̇k

Turkish Journal of Veterinary & Animal Sciences

This research was carried out to determine the seroprevalence of Bovine Viral Diarrhoea Virus (BVDV), Bovine Herpes Virus 1 (BoHV-1), and Bovine Herpes Virus 4 (BoHV-4) in cattle (n = 188) in Ağrı province of Eastern Anatolia Region, Turkey. The presence of BVDV, BoHV-1, and BoHV-4 antibodies in sera samples were determined by an ELISA test kit. It was determined that the highest seropositivity for BoHV-1 in Tutak disrict (9.9%), in ≤ 3 years age groups (3.39%), and in Simmental cattle (14.28%); for BoHV-4 in Doğubeyazıt disrict (4.16%), %), in ≤ 3 years age groups (1.70%), and in Simmental cross …

Pulse Steroid Treatment For Hospitalized Adults With Covid-19, Ayşe Batirel, Recep Demi̇rhan, Nurullah Eser, Ezgi̇ Körlü, Mehmet Engi̇n Tezcan

Turkish Journal of Medical Sciences

Background/aim: High-dose steroid has been shown to reduce the mortality rate in Corona virus disease 2019 (COVID-19) patients who need oxygen support. Here, we evaluated the effectiveness of pulse-steroid in case of unresponsiveness to treatment with high dose steroid. Materials and methods: The study is a retrospective controlled trial. We divided the patients in 3 groups: standard-care therapy alone, high-dose steroid treatment (6 mg/day dexamethasone equivalent), and pulse-steroid treatment (250 mg/day methyl-prednisolone). One hundred and fifty patients were enrolled in each group. All patients were hospitalized and needed oxygen support. We matched the patients according to disease severity at the …

Galectin-3: Can It Be A Diagnostic Tool For Pneumonia In Covid-19 Patients?, Emi̇ne Kartal Baykan, Engi̇n Şebi̇n, Ömer Karaşahi̇n, Ahmed Rami̇z Baykan, Serkan Cerrah, Hasan Göğebakan, Can Sevi̇nç, Mustafa Kahraman, Yasemi̇n Coşkun Yavuz

Turkish Journal of Medical Sciences

Background/aim: Biochemical markers are needed to show lung involvement in COVID-19 disease. Galectin-3 is known to play a key role in the inflammation and fibrosis process. We aimed to evaluate the predictive role of galectin-3 levels for pneumonia in patients with COVID-19. Materials and methods: Total of 176 patients with COVID-19, confirmed with reverse transcriptase polymerase chain reaction, admitted to the Erzurum Regional Training and Research Hospital was analyzed. The study was designed as a cross sectional. The baseline data of laboratory examinations, including galectin-3 were collected at the time of diagnosis. CT images evaluated by a single radiologist according …

Clinical Characteristics And Risk Factors For 28-Day Mortality In Critically Ill Patients With Covid-19: A Retrospective Cohort Study, Mehmet Nuri̇ Yakar, Begüm Ergan, Bi̇şar Ergün, Murat Küçük, Ali̇ Cantürk, Mahmut Cem Ergon, Naci̇ye Si̇nem Gezer, Erdem Yaka, Bi̇lgi̇n Cömert, Ali̇ Necati̇ Gökmen

Turkish Journal of Medical Sciences

Background: To date, the coronavirus disease 2019 (COVID-19) caused more than 2.6 million deaths all around the world. Risk factors for mortality remain unclear. The primary aim was to determine the independent risk factors for 28-day mortality. Materials and Methods: In this retrospective cohort study, critically ill patients (≥ 18 years) who were admitted to the intensive care unit due to COVID-19 were included. Patient characteristics, laboratory data, radiologic findings, treatments, and complications were analyzed in the study. Results: A total of 249 patients (median age 71, 69.1% male) were included in the study. 28-day mortality was 67.9% (n = …

Low Immunity Against Vaccine Preventable Diseases In Turkish Hiv Cohort, Aslihan Candevi̇r, Feri̇t Kuşcu, Fi̇gen Yildirim, Süheyla Kömür, Gönül Çi̇çek Şentürk, Ayşe Seza İnal, Fatma Eser, Sali̇h Çeti̇ner, Behi̇ce Kurtaran, Yeşi̇m Taşova

Turkish Journal of Medical Sciences

Background/aim: HIV infection increase the risk of serious disease resulting from common vaccine-preventable infections. Vaccinations are particularly important for HIV infected adults. We aimed to investigate the immunity rates against measles, mumps, rubella, hepatitis A, B, and tetanus in newly diagnosed HIV patients. Materials and methods: Patients who admitted to outpatient clinics of three centers with newly diagnosed HIV infection, between 1 January 2015 and 31 June 2017 were included. Measles, mumps, rubella, varicella zoster virus, hepatitis A, hepatitis B, and tetanus antibody levels were measured by commercial diagnostic kits. Demographical and laboratory data of the patients were recorded. Results: …

History Repeats Itself: Horse Originated Hyperimmune Sera Production Against Sars Cov-2, Ahu Pakdemi̇rli̇, Elvi̇n Çalişkan, Sabri̇ Hacioğlu, Erdem Danyer, Özlem Kardoğan, Züleyha Ergün Kurt, Özcan Yildirim, Hakan Taşkaya, Bora Ündar, Yasemi̇n Sezgi̇n, Gencay Ergi̇n, Hi̇mmet Eki̇ci̇, Ufuk Ülker, Erkan Taçbaş, Şahi̇n Çakir

Turkish Journal of Medical Sciences

Background/aim: SARS-CoV-2 disease was announced as a pandemic by The World Health Organization in early 2020. It is still threatening the world population. Here, we aimed to produce hyperimmune sera that contain immunoglobulin G and F(ab')2 fragments sourced from horse antibodies as an urgent response to the pandemic. Materials and methods: SARS-CoV-2 was produced and inactivated with three different methods [formaldehyde (FA), formaldehyde, and binary ethylene amine (FA + BEI), and heat treatment]. After in vitro inactivation control, immunogens were mixed with Freund's adjuvant, thereafter horses (n: 2 for FA, 4 for FA + BEI, 2 for heat inactivation) and …

Assessment Of Fragmented Qrs Formation And Its Relationship With Left Ventricularhypertrophy In Nonhypertensive Acromegaly Patients, Muhammet Dural, Göknur Yorulmaz, Eli̇f Sevi̇l Alagüney, Kadi̇r Uğur Mert, Ezgi̇ Çamli, Ahmet Toygar Kalkan, Aysen Akalin, Medi̇ne Nur Kebapçi, Ahmet Serdar Yilmaz, Selda Murat, Fatma Belgi̇n Efe

Turkish Journal of Medical Sciences

Background/aim: It is known that the presence of fragmented QRS (fQRS) on electrocardiography (ECG) is associated with cardiovascular events. The aim of this study was the evaluation of fQRS formation and its relationship with the left ventricular hypertrophy (LVH) parameters in acromegaly patients. Materials and methods: In total, 47 previously diagnosed with non-hypertensive acromegaly patients and 48 control subjects were included in the study. ECG and transthoracic echocardiography (TTE) were performed for each participant. Acromegaly patients were divided into two groups according to the fQRS formation on the ECG. Left ventricular wall thicknesses, and left atrial diameter (LAD), left ventricular …

Allergic Bronchopulmonary Aspergillosis In Children, Özge Atay, Suna Asi̇lsoy, Gi̇zem Atakul, Serdar Al, Özge Kangalli Boyacioğlu, Nevi̇n Uzuner, Özkan Karaman

Turkish Journal of Medical Sciences

Background/aim: Allergic bronchopulmonary aspergillus (ABPA) is a lung disease caused by hypersensitivity from Aspergillus fumigatus. Diagnostic criteria, staging systems and treatment methods for ABPA disease have been reported in studies evaluating populations, the majority of which are adult patients. Our study aimed to discuss the use of ABPA diagnostic criteria in children, the success of other alternative regimens to oral corticosteroids in the treatment of ABPA, and the changes that occur during treatment, in the light of the literature. Materials and methods: Between January 2017 and 2020, patients diagnosed with ABPA at the Dokuz Eylül University Child Allergy and Immunology …

Diagnostic Value Of Procalcitonin And C Reactive Protein For Infection And Sepsis Inelderly Patients, Çi̇ler Zi̇nci̇rci̇oğlu, Kazim Rollas, Işil Güldoğan, Aykut Saritaş, Hüseyi̇n Özkarakaş, Gürsel Ersan, Ni̇met Şenoğlu

Turkish Journal of Medical Sciences

Background/aim: Biomarkers are useful for diagnosing infection and sepsis in adults, but data are limited in elderly patients. Furthermore, clinical symptoms of infection in elderly patients are usually atypical or unclear. We aimed to assess the usefulness of PCT, CRP, and WBC in distinguishing elderly patients infected with sepsis from infected without sepsis and those with no-infection. We also aimed to find a cut-off value for diagnosing sepsis and infection without sepsis in elderly critically ill patients. Materials and methods: In this single-center and prospective observational study, patients older than 65 years were enrolled. Serum levels of PCT, CRP, and …

Comparison Of Sars-Cov-2 Antibody Assays In Pcr Negative And Pcr Positive Turkishpatients, Ayşegül Karahasan, Rabi̇a Can Sarinoğlu, Bariş Can, Hüseyi̇n Bi̇lgi̇n, Nuri̇ Çagatay Çi̇mşi̇t, Volkan Korten

Turkish Journal of Medical Sciences

No abstract provided.