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An Agenda-Setting Report: Biome Monitoring For Human Health, Peter Roumeliotis

Public Health Theses

In light of the COVID-19 pandemic and the increasing frequency with which zoonotic diseases of pandemic potential have emerged in recent decades, it is vital to seek new methods of preventing disease outbreaks before they occur. Novel information age technologies have the potential to change the game for infectious disease outbreak monitoring. This paper addresses the overall opportunity that exists for biome surveillance as a means for health monitoring, particularly the way that the domains of technological and biological sciences can unite to prevent the next pandemic before it gets a chance to take hold. This report outlines the numerous …

Determining The Relationship Between Sars-Cov-2 Infection And Streptococcus Pneumoniae In Clinical Saliva Samples, Anne Watkins

Public Health Theses

Background. Streptococcus pneumoniae is a commonly found upper respiratory tract colonizer that can progress to more severe disease forms such as pneumonia. Interactions with respiratory viruses other than SARS-CoV-2 have been previously identified such that S. pneumoniae may sometimes enhance disease or occur as a secondary or co-infection. With the recent emergence of SARS-CoV-2 there is limited data available describing this specific pathogen relationship that could play a role in the breadth and severity of the pandemic. Methods. Inpatients and healthcare workers testing positive for SARS-CoV-2 March 2020-August 2020 were tested for S. pneumoniae through saliva culture enrichment and RT-qPCR …

Vector-Host Interactions Of Culex Pipiens Mosquitoes And Their Role In Arbovirus Transmission In The Mid-Atlantic United States, Karen Jane Yuan

Public Health Theses

As the primary vector for the West Nile virus in the United States, members of the Culex pipiens complex have caused illnesses and deaths in the human population since its discovery in 1937. The potential contribution of Cx. pipiens to transmission and enzootic amplification of WNV can be influenced by multiple aspects, including their interactions with various vertebrate hosts as an important factor. By using blood meal analysis and virus testing, this study further investigated the role of Cx. pipiens in WNV transmission and amplification. With 91% of blood meals identified from avian species, birds remain the most frequent source …

Biocybersecurity: A Converging Threat As An Auxiliary To War, Lucas Potter, Orlando Ayala, Xavier-Lewis Palmer

Engineering Technology Faculty Publications

Biodefense is the discipline of ensuring biosecurity with respect to select groups of organisms and limiting their spread. This field has increasingly been challenged by novel threats from nature that have been weaponized such as SARS, Anthrax, and similar pathogens, but has emerged victorious through collaboration of national and world health groups. However, it may come under additional stress in the 21st century as the field intersects with the cyberworld-- a world where governments have already been struggling to keep up with cyber attacks from small to state-level actors as cyberthreats have been relied on to level the playing field …

Molecular And Genetic Studies On A Sipd/Ipad-Related Virulence Spike Protein From Immune-Suppressive Particles Of A Drosophila Parasitoid, Carlo Miguel A. Sevilla

Dissertations and Theses

Parasitoid wasps are effective biological control agents that have evolved intricate host immune suppression strategies to overcome host immune defenses. The most important anti-parasite defense mechanism is encapsulation, where the host’s blood cells surround the wasp egg. In the Drosophila/Leptopilina host-parasitoid system, extracellular vesicles (EVs) are oviposited along with the wasp egg. The EVs possess spikes and contain hundreds of proteins, some of which enable wasp eggs to escape encapsulation by changing the morphology and function of hemocytes, or killing them. Previous studies have identified an abundant surface/spike protein (SSp40) from Leptopilina heterotoma EVs. While p40, a predicted …

Incidence And Severity Of Drug Interactions Before And After Switching Antiretroviral Therapy To Bictegravir/Emtricitabine/Tenofovir Alafenamide In Treatment-Experienced Patients., Jason J. Schafer, Pharmd, Mph, Bcps, Aahivp, Neha S Pandit, Agnes Cha, Emily Huesgen, Melissa Badowski, Elizabeth M Sherman, Jennifer Cocohoba, Ayako Shimada, Scott W Keith

College of Pharmacy Faculty Papers

Background: Switching antiretroviral therapy (ART) in people with HIV (PWH) can influence their risk for drug-drug interactions (DDIs). The purpose of this study was to assess changes in the incidence and severity of DDIs among PWH who switched their ART to bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF).

Methods: This was a multicenter retrospective cohort study of PWH on ART and at least 1 concomitant medication (CM) who switched to BIC/FTC/TAF between 3/2018 and 6/2019. Using the University of Liverpool's HIV Drug Interaction Database, 2 DDI analyses were performed for each patient. The first assessed patients' preswitch ART regimens with their CM list. The …

A Moral And Pragmatic Analysis Of Debt And North–South Economic Inequality, George Atisa

Public Affairs and Security Studies Faculty Publications

The North–South inequality hurts both high- and low-income countries in many respects, both directly and indirectly. At the same time, workers from low-income countries work just as hard as those from high-income countries but are often held in abject poverty by circumstances not of their own making. The question the study tries to find answers for is: why do hard-working individuals in both the North and the South bring home different levels of income, yielding big differences in per capita income globally and what can be done about it? Current pro-poor growth policies that include handouts, loans or relocating industries …

Residency And Sociality Analysis Of Skin Lesions In Bottlenose Dolphins (Tursiops Truncatus) Of The St. Johns River, Fl, Brittney Divittore-Goodrum

UNF Graduate Theses and Dissertations

Photo analysis of skin lesions is a non-invasive method to measure the health of cetacean populations. The St. Johns River (SJR) in NE Florida is an estuarine system inhabited by bottlenose dolphins that is characterized by high levels of anthropogenic activity, which can impact dolphin health. Social transmission of disease may influence lesion formation in dolphins; thus this study aimed to determine if skin lesion prevalence and body coverage differed based on 1) the amount of time spent in the SJR annually and 2) sociality measures. The dataset was restricted to three 12-month periods, based on the occurrence of an …

Privacy-Preserving Outsourced Clinical Decision Support System In The Cloud, Ximeng Liu, Robert H. Deng, Kim-Kwang Raymond Choo, Yang Yang

Research Collection School Of Computing and Information Systems

In this paper, we propose a privacy-preserving clinical decision support system using Naïve Bayesian (NB) classifier, hereafter referred to as Peneus, designed for the outsourced cloud computing environment. Peneus allows one to use patient health information to train the NB classifier privately, which can then be used to predict a patient's (undiagnosed) disease based on his/her symptoms in a single communication round. Specifically, we design secure Single Instruction Multiple Data (SIMD) integer circuits using the fully homomorphic encryption scheme, which can greatly increase the performance compared with the original secure integer circuit. Then, we present a privacy-preserving historical Personal Health …

An Investigation Of The Role Of Basigin-Variant-1 In The Immune Response Within The Retina, Abigail D. Tompa

UNF Graduate Theses and Dissertations

The neural retina is considered an immune privileged area, in that the eye attempts to suppress the inflammatory response to preserve vision. If there is damage to the blood-retina barrier, such as in diabetes or macular degeneration, it is possible for monocytes to travel out of the blood vessels and into the retina. While studying retinoblastoma, a research group determined that the protein, Basigin, through its extracellular domain, elicits an immune response by enhancing transcription of the pro-inflammatory cytokine interleukin-6 (IL-6). Basigin is cell adhesion molecule that belongs to the immunoglobulin superfamily. The Basigin gene has two main transcripts, that …

An Examination Of The Impact Of The Covid-19 Health Threat, Stress, And Social Isolation On Lifestyle Habits As Analyzed Through The Protection Motivation Theory, Luciana Adib Soares

UNF Graduate Theses and Dissertations

The COVID-19 emerged in China in 2019 and quickly spread to other countries, leading to mandated lockdowns and social isolation. This cross-sectional study examined the impact of the COVID-19-generated stress, health threat, and social isolation on dietary, physical activity, and self-care habits of adults in Florida, utilizing the PMT as a framework. Participants (n = 478) completed online surveys about demographics, perceived stress, and changes in lifestyle habits. Significant positive changes were reported in cooking at home (p < .001) frequency, sweets (p < .001), and breakfast (p = .009) consumption, outdoors physical activity (p = .005), self-care (p < .001), relaxation (p < .001), and rest (p < .001) habits. Significant negative changes were reported in fast food (p = .004) and snack (p < .001) consumption. A significant relationship existed between self-reported stress, perceived threat, (r = .33, p < .001), and perceived efficacy, (r = -.15, p = .002). Perceived threat was the most important predictor of changes …

Women Cios In Higher Education Pursuing Work-Life Balance/Integration, Self-Care, And The Influence Of Covid-19, Candice Jo Veilleux-Mesa

UNF Graduate Theses and Dissertations

There is a gender gap within higher education (HE) administration, and specifically the Chief Information Officer (CIO) position. This is a problem because men and women administrators provide diverse perceptions and advantages to HE institutions. The CIO perspective is important because they perform a critical role in the IT management and organization of HE institutions. Additionally, women in leadership positions often face additional pressures and barriers as compared to their men counterparts when seeking to integrate their work, family, and personal self-care. Thus, to further understand and take action to improve representation of women HE CIOs, the purpose of this …

Covid-19: The Spearpoint Of Human–Wildlife Interactions, Terry A. Messmer

Human–Wildlife Interactions

This is the letter from the editor-in-chief.

Covid-19 Third Wave: A Challenge For Overburdened And Underdeveloped Healthcaresystem Of Pakistan, Mohammad Ejaz, Muhammad Ali Syed

Turkish Journal of Medical Sciences

No abstract provided.

Value Of Strain-Wave Sonoelastography As An Imaging Modality In Assessment Ofbenign Acute Myositis In Children, Ayşe Seçi̇l Ekşi̇oğlu, Ayla Akca Çağlar, Seda Kaynak Şahap, Can Demi̇r Karacan, Ni̇lden Tuygun

Turkish Journal of Medical Sciences

Background/aim: Although sonoelastography is applied in assessment of many organs, studies for evaluation of muscles are very few in number and are mostly limited to adults. With this prospective study, we aimed to evaluate the value of sonoelastography in assessment of influenza related benign acute myositis in children. Materials and methods: This study enrolled 25 patients with a clinical diagnosis of benign acute childhood myositis (BACM) and 25 age and sex-matched healthy controls. All patients presented to our emergency department with the complaint of inability to walk and had increased serum creatine kinase (CK) levels. All patients underwent strain elastography …

Perspectives For Immune Plasma Treatment Of Covid-19, Başak Sayinalp, Olgu Erki̇n Çinar, İbrahi̇m Celaletti̇n Haznedaroğlu

Turkish Journal of Medical Sciences

Background/aim: The SARS-CoV-2 infection was declared as a pandemic by the World Health Organization (WHO) on March 11, 2020, and the death toll from COVID-19, which is the disease caused by SARS-CoV-2, has already surpassed that of many previous epidemics. A wide variety of treatment options are being considered for COVID-19, but there is still no definitive treatment or vaccine. This study aims to explain the background of convalescent plasma (CP) treatment and its relations with COVID-19 immunity, to define ideal treatment procedures, and to reveal present and future perspectives in the light of the rapidly growing data. Immunological basis …

Evaluation Of Initial Chest Computed Tomography (Ct) Findings Of Covid-19pneumonia In 117 Deceased Patients: A Retrospective Study, Yasemi̇n Gündüz, Oğuz Karabay, Ali̇ Fuat Erdem, Erbi̇l Arik, Mehmet Hali̇l Öztürk

Turkish Journal of Medical Sciences

Background/aim: There is no study in the literature in which only chest computed tomography (CT) findings of deceased cases obtained at admission were examined, and the relationship between these findings and mortality was evaluated. Materials and methods: In this retrospective study, a total of 117 deceased patients with COVID-19 infection confirmed by positive polymerase chain reaction and undergone chest CT were enrolled. We evaluated initial chest CT findings and their relationship, location, prevalence, and the frequency with mortality. Results: The mean age of patients was 73 ±18 years; 71 of all patients were male and 46 were female. The predominant …

Impact Of Hospital-Acquired Acute Kidney Injury On Covid-19 Outcomes In Patients Withand Without Chronic Kidney Disease: A Multicenter Retrospective Cohort Study, Savaş Öztürk, Kenan Turgutalp, Mustafa Arici, Hakki Çeti̇nkaya, Mehmet Riza Altiparmak, Zeki̇ Aydin, Zeki̇ Soypaçaci, Feyza Bora, Ekrem Kara, Egemen Cebeci̇, Tuba Eli̇f Özler, Mürşi̇de Esra Dölarslan, Savaş Si̇pahi̇, Yavuz Ayar, İdri̇s Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: Hospital-acquired acute kidney injury (HA-AKI) may commonly develop in Covid-19 patients and is expected to have higher mortality. There is little comparative data investigating the effect of HA-AKI on mortality of chronic kidney disease (CKD) patients and a control group of general population suffering from Covid-19. Materials and methods: HA-AKI development was assessed in a group of stage 3-5 CKD patients and control group without CKD among adult patients hospitalized for Covid-19. The role of AKI development on the outcome (in-hospital mortality and admission to the intensive care unit [ICU]) of patients with and without CKD was compared. Results: …

Effects Of The Covid-19 Pandemic On Psychology And Disease Activity In Patients Withankylosing Spondylitis And Rheumatoid Arthritis, Şaki̇r Gica, Yasemi̇n Akkubak, Zaki̇re Kübra Aksoy, Adem Küçük, Erkan Cüre

Turkish Journal of Medical Sciences

Background/aim: The COVID-19 outbreak is known to increase stress levels of most patients with chronic diseases. Patients with ankylosing spondylitis (AS) and rheumatoid arthritis (RA) are highly susceptible to environmental stress. In the current study, we aimed to determine how the COVID-19 pandemic psychologically affected patients with chronic progressive diseases such as AS and RA and the effects of these psychological factors on disease activity. Materials and methods: Age and sex-matched patients with AS (n = 80), RA (n = 80), and healthy controls (n = 80) were included in the study. All participants were evaluated with the "Perceived COVID-19 …

Addressing The Ecological Fallacy With Lagrangian Inference, Michael Schwob

Calvert Undergraduate Research Awards

Most epidemiologists elect to use statistical models that use population-level data to make inference on the spread of some virus or disease. This has become commonplace in the fields of epidemiology and biostatistics since most data used to construct and verify epidemic models are recorded at the population-level. Obtaining inference from a population-level model may be beneficial in studying the spread of disease in a homogeneous population, but the use of such models to describe a heterogeneous population results in inadequate inference. The inaccuracy of these models is further amplified when one tries to make individual-level inference from these population-level …

Repairing Warranted Public Trust In Science Through Political Reconciliation, Anna Cat Jay Reely

Graduate Student Theses, Dissertations, & Professional Papers

The ability of science-based policy to promote public welfare is contingent upon the presence of warranted public trust. However, as exposed by the case of COVID-19 vaccination efforts, public trust in the scientific community is not so readily attained. Many communities, particularly those who are systematically marginalized, have suffered severe harm in the name of scientific advancement. As a manifestation of tarnished rapport, individuals within these communities arguably engage in warranted distrust. While many scholars have attempted to articulate the conditions for warranted public trust in science, proposals have failed to account for the non-neutral state of the relationship between …

Leakage Versus Material Filtration In Barrier Facemask Efficiency, Ali Bahloul, Clothilde Brochot, Barbara Layne

Études primaires

The World Health Association and many governmental agencies recommend the wearing of facemasks by the general public to prevent the spread of COVID-19. It is believed that masks can significantly protect others and may offer some protection to the wearer. Although there are standards for FFRs, surgical masks, and recently for barrier face coverings, they all indicate the level of protection for the wearer. However, testing facial masks not at the point of inhalation, but at the source, the exhale, offers a new perspective on how to impede particle emissions. In this paper, the experimental results show that, although the …

Functional Consequences Of Apoptosis Gene Diversification In Eastern Oyster Immunity, Erin Michele Witkop

Open Access Dissertations

The eastern oyster is an ecologically and economically important filter feeding bivalve mollusc endemic to the east coast of the United States. Outbreaks of disease, such as Dermo disease caused by the parasite Perkinsus marinus, threaten natural oyster populations, and oysters have evolved a complex innate immune system containing large, expanded gene families to combat the diverse array of pathogens in their environment. Apoptosis, or programmed cell death, is a critical immune response to Dermo disease involving a series of expanded gene families, including the Inhibitor of Apoptosis (IAP) family of apoptosis regulatory molecules. The goal of this research is …

Occult Hepatitis B Virus Infection In A Kenyan Cohort Of Hiv Infected Anti-Retroviral Therapy Naïve Adults, Adil Salyani, Jasmit Shah, Rodney Adam, George Otieno, Evelyn Mbugua, Reena Shah

Internal Medicine, East Africa

Background: Occult hepatitis B virus (HBV) infection (OBI) is a phase of HBV infection characterised by the presence of HBV DNA in the absence of detectable hepatitis B surface antigen (HBsAg). OBI is of concern in the HIV-infected due to high prevalence and risk of HBV reactivation. The prevalence and clinico-demographic characteristics of OBI in anti-retroviral therapy (ART) naïve HIV infected adults in Kenya is unknown.

Methods: A cross sectional study carried was out at three sites in Kenya. HIV infected ART naïve adults were enrolled and demographic data collected. Blood samples were assayed for HBsAg, HBV DNA, alanine aminotransferase, …

Seroprevalence Of Hepatitis B Virus Infection, Anti-Hcv Antibodies And Hiv And Knowledge Among People Who Use Drugs Attending Methadone Therapy Clinic In Tanzania: A Cross-Sectional Study, Semvua B. Kilonzo, Daniel I. W Gunda, David C. Majinge, Hyasinta Jaka, Paulina M. Manyiri, Fredrick Kalokola, Grahame Mtui, Elichilia R. Shao, Fatma Bakshi, Alex Stephano

Internal Medicine, East Africa

Background: Methadone therapy clinics have been recently introduced in Tanzania, aiming at reducing risk behaviors and infection rates of viral hepatitis and HIV among people who use drugs. The objective of this study was to estimate the prevalence, associated factors and knowledge level of these conditions among people who use drugs attending a methadone clinic in Tanzania.

Methods: We enrolled 253 People who using drugs receiving Methadone therapy. Clinical data was retrospectively collected from the medical records and face-to face interviews were conducted to determine the behavioral risk factors and respondents’ knowledge on viral hepatitis and HIV.

Results: An overall …

Collaboration Between Public Health And Marketing Experts As A Response To Covid-19, M. Courtney Hughes, Yihui Tang, Shupei Yuan

Faculty Articles, Papers, and Other Scholarship

Since the beginning of 2020, as the world’s population has dealt with COVID-19 and abrupt changes to the normal status quo, academic scholars are no exception, experiencing radical changes to their teaching modalities (remote versus in-person) and often major interruptions in their research. One month after the initial shift to working remotely in March, we obtained approval from Northern Illinois University’s Institutional Review Board to conduct a brief survey with recently published academic scholars in the fields of public health and marketing to understand their views of how this unprecedented time may affect their work. In examining patterns in the …

A Computational Simulation-Based Framework For Estimating Potential Product Impact During Product Design, Christopher S. Mabey, Andrew G. Armstrong, Christopher A. Mattson, John L. Salmon, Nile W. Hatch, Eric C. Dahlin

Faculty Publications

The impact of engineered products is a topic of concern in society. Product impact may fall under the categories of economic, environmental or social impact, with the last category defined as the effect of a product on the day-to-day life of people. Design teams lack sufficient tools to estimate the social impact of products, and the combined impacts of economic, environmental and social impacts for the products they are designing. This paper aims to provide a framework for the estimation of product impact during product design. To estimate product impact, models of both the product and society are required. This …

Role Of Partnership In Hiv-Related Outcomes In Heterosexual Individuals Newly Diagnosed With Hiv, Maira Sohail

All ETDs from UAB

A supportive intimate partner has shown to be helpful in HIV care of men who have sex with men, and in some African heterosexual couples; however, knowledge on this phenomenon among heterosexual people with HIV (PWH) is limited in the United States context. This project included two quantitative studies and one qualitative study to examine the role of intimate partnership in HIV care among heterosexual, newly diagnosed PWH. Both quantitative studies were conducted among heterosexual, newly diagnosed (2013-2017) individuals at the University of Alabama at Birmingham (UAB) 1917 Clinic. The first study examined the role of partnership (un-partnered, unmarried-partnered, and …

From Classrooms To Polluted Communities: Scientific Inquiry In Birmingham, Alabama And Beyond, Sarah Jeanne Adkins-Jablonsky

All ETDs from UAB

Nearly half of all U.S. students who declare science majors in college do not graduate with science degrees within six years. Improvements in science outcomes are linked with active-learning pedagogies such as Course-based Undergraduate Research Experiences (CUREs). However, despite the need for education reform particularly in Alabama, active-learning interventions are severely understudied in Alabama universities. Chapter 1 describes novel CUREs at four colleges in Birmingham, AL: The University of Alabama at Birmingham (UAB); Jefferson State Community College (JSCC), Samford University (SU), and Birmingham Southern College (BSC). Chapter 2 shows how an agar art CURE, The Art of Microbiology, impacts student …

Social Inclusion Among People With Mobility Limitations In The Global South, Shane Burns

All ETDs from UAB

An estimated 15% of the world’s population have a disability—roughly 80% of whom live in the Global South. People with disabilities experience profound social disparities that affect their quality of life and social inclusion. Due to the array of cultural perspectives and institutional capacities around the globe, provision of disability rights can come with its challenges. In many cultural contexts, people have moral beliefs about disability that result in shame. More medicalized beliefs toward disability are often the result of medical infrastructure that offers goods and services. Using a framework that arrays these moral and medical dimensions, I theorized that …