Digital Commons Network^™

Sars-Cov-2 Infection Severity Is Linked To Superior Humoral Immunity Against The Spike, Jenna J Guthmiller, Ya-Nan Dai, Christopher A Nelson, Paige D Hall, Daved H Fremont, Et Al

Open Access Publications

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently causing a global pandemic. The antigen specificity of the antibody response mounted against this novel virus is not understood in detail. Here, we report that subjects with a more severe SARS-CoV-2 infection exhibit a larger antibody response against the spike and nucleocapsid protein and epitope spreading to subdominant viral antigens, such as open reading frame 8 and nonstructural proteins. Subjects with a greater antibody response mounted a larger memory B cell response against the spike, but not the nucleocapsid protein. Additionally, we revealed that antibodies against the spike are still capable …

Development Of Polymorphic Markers In The Immune Gene Complex Loci Of Cattle, K Bakshy, D Heimeier, J C. Schwartz, E J. Glass, S Wilkinson, R A. Skuce, A R. Allen, J Young, J C. Mcclure, J B. Cole, D J. Null, J A. Hammond, T P.L. Smith, D M. Bickhart

Roman L. Hruska U.S. Meat Animal Research Center: Reports

The addition of cattle health and immunity traits to genomic selection indices holds promise to increase individual animal longevity and productivity, and decrease economic losses from disease. However, highly variable genomic loci that contain multiple immune-related genes were poorly assembled in the first iterations of the cattle reference genome assembly and underrepresented during the development of most commercial genotyping platforms. As a consequence, there is a paucity of genetic markers within these loci that may track haplotypes related to disease susceptibility. By using hierarchical assembly of bacterial artificial chromosome inserts spanning 3 of these immune-related gene regions, we were able …

Prevalence Of Malaria Parasite Infections Among U.S.-Bound Congolese Refugees With And Without Splenomegaly., Moses Mwesigwa, Jessica L. Webster, Sam Lubwama Nsobya, Alexander Rowan, Mukunda Singh Basnet, Christina R. Phares, Michelle Weinberg, Alexander Klosovsky, Marwan Naoum, Philip J. Rosenthal, William Stauffer

Student Papers, Posters & Projects

All U.S.-bound refugees from sub-Saharan Africa receive presumptive antimalarial treatment before departing for the United States. Among U.S.-bound Congolese refugees, breakthrough malaria cases and persistent splenomegaly have been reported. In response, an enhanced malaria diagnostic program was instituted. Here, we report the prevalence of plasmodial infection among 803 U.S.-bound Congolese refugees who received enhanced diagnostics. Infections by either rapid diagnostic test (RDT) or PCR were detected in 187 (23%) refugees, with 78 (10%) by RDT only, 35 (4%) by PCR only, and 74 (9%) by both. Infections identified by PCR included 103 monoinfections (87 Plasmodium falciparum, eight Plasmodium ovale, seven …

The Rider (2021-01-18), Jacqueline Peraza

The Rider Archives

Vol.6 No.16

2021-01-18_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Crow's Nest, January 18, 2021, Crow's Nest Staff

Crow's Nest

The January 18, 2021, issue of the Crow's Nest.

Disparities In Cardiovascular Research Output And Disease Outcomes Among High-, Middle- And Low-Income Countries - An Analysis Of Global Cardiovascular Publications Over The Last Decade (2008-2017), Nada Qaisar Qureshi, Syed Hamza Mufarrih, Gerald S. Bloomfield, Wajeeha Tariq, Aysha Almas, Ali H. Mokdad, Muhammad Imran Nisar, Sameen Siddiqi, Zulfiqar Ahmed Bhutta, Zainab Samad

Department of Medicine

Background: Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. Health research is crucial to managing disease burden. Previous work has highlighted marked discrepancies in research output and disease burden between high-income countries (HICs) and low- and lower-middle-income countries (LI-LMICs) and there is little data to understand whether this gap has bridged in recent years. We conducted a global, country level bibliometric analysis of CVD publications with respect to trends in disease burden and county development indicators.
Methods: A search filter with a precision and recall of 0.92 and 0.91 respectively was developed to extract cardiovascular publications …

2021-01-17_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

23-Valent Polysaccharide Vaccine (Ppsv23)-Targeted Serotype-Specific Identification Of Streptococcus Pneumoniae Using The Loop-Mediated Isothermal Amplification (Lamp) Method, Jiwon Lee, Youngbae Yoon, Eun Jin Kim, Donghyun Lee, Yeoungjun Baek, Chika Takano, Bin Chang, Takahiro Iijima, Paul E. Kilgore, Satoshi Hayakawa, Tomonori Hoshino, Dong Wook Kim, Mitsuko Seki

Department of Pharmacy Practice

Reports of invasive disease due to Streptococcus pneumoniae have declined since the introduction of pneumococcal conjugate vaccines (PCV7 and PCV13). The incidence of invasive diseases due to S. pneumoniae that are not addressed by the vaccines, however, has increased in children and adults, creating a global public health problem. Previously, we established the loop-mediated isothermal amplification (LAMP) method for a PCV13 serotype-specific assay. In the current study, we developed a rapid, simple, and cost-effective assay to detect serotypes in the 23-valent pneumococcal polysaccharide vaccine (PPSV23) using the LAMP method. In this study, LAMP primer sets for serotypes 2, 8, 9N, …

2021-01-16_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

A Survey Of Horse Use And Management In Horse Clubs In China: A Pilot Study, Zhen Li Ph.D., Msc, Shea Porr Phd

Steeplechase: An ORCA Student Journal

Rapid development of the Chinese equine industry in the last two decades has resulted in an increased equine population without trained personnel to support industry growth. The purpose of this study was to understand the present profile of horse use in horse clubs in China from the perspective of horse welfare. The survey was distributed to specific personnel in selected Chinese horse clubs, and snowball sampling techniques were used to increase response rates. Of 20 respondents, the oldest club was established in 2002 and the newest in 2018. Fourteen clubs were membership-based, providing services for 40-1000 members and up to …

Coronavirus Update 1-15-21, The Coronavirus Planning Team

University Briefings & Virtual Events

The Importance of Masks and Social Distancing: SHU Professor Sofia Pendley is quoted in an article on diverseeducation.com about how to prevent the spread of COVID-19 on college campuses. The article discusses a study on COVID prevention that found that extensive distancing and mandatory mask wearing alone can prevent 87% of campus COVID-19 infections. In the article, Professor Pendley shares SHU’s success in preventing spread in the classroom using these protocols.

2021-01-15_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Production Of Embryos And A Live Offspring Using Post Mortem Reproductive Material From Bison (Bison Bison Bison) Originating In Yellowstone National Park, Usa, Hayley M. Benham, Matthew P. Mccollum, Pauline Nol, Rebecca K. Frey, P. Ryan Clarke, Jack C. Rhyan, Jennifer P. Barfield

United States Department of Agriculture Wildlife Services: Staff Publications

Bison from Yellowstone National Park (YNP) have an important genetic history. As one of the few wild herds of bison with no evidence of cattle DNA introgression and a large enough population to maintain genetic diversity, they are considered a conservation priority for the species. Unfortunately, there is a high prevalence of the zoonotic disease brucellosis in the herd. Part of the management strategy for controlling the disease and herd size in YNP is to remove bison from the population during the winter migration out of the park. This interagency management cull provides an opportunity to collect a large number …

Holy Cross Magazine, Vol. 55, No. 1, Winter 2021, College Of The Holy Cross

Holy Cross Magazine

Bring Kimball to Your Kitchen
Recipes: Baked Buffalo Chicken; Sautéed Cabbage with Basil; Kimball bakery Magic Bars; Crossroads mac and Cheese

Faculty Film Explores the Indigenous and Environmental History of Holy Cross
Professors highlight the history of the Nipmuc, the Blackstone River, the College campus and its surrounding neighborhood
By Mary Cunningham ’17

Faculty/Student Research Aims to Discover More About Breast Cancer Tumors
By Maura Sullivan Hill

Syllabus: Eating and Its Disorders
with Jumi Hayaki, professor of psychology
By Lori Ferguson

“I Mean, Is This Really Happening? It is.”
After a career fighting outbreaks from AIDS to Ebola, Anthony Fauci, …

High-Density Lipoproteins And Serum Amyloid A (Saa), Nancy R. Webb

Pharmacology and Nutritional Sciences Faculty Publications

PURPOSE OF REVIEW: Serum amyloid A (SAA) is a highly sensitive acute phase reactant that has been linked to a number of chronic inflammatory diseases. During a systemic inflammatory response, liver-derived SAA is primarily found on high-density lipoprotein (HDL). The purpose of this review is to discuss recent literature addressing the pathophysiological functions of SAA and the significance of its association with HDL.

RECENT FINDINGS: Studies in gene-targeted mice establish that SAA contributes to atherosclerosis and some metastatic cancers. Accumulating evidence indicates that the lipidation state of SAA profoundly affects its bioactivities, with lipid-poor, but not HDL-associated, SAA capable of …

A Global Review On Short Peptides: Frontiers And Perspectives, Vasso Apostolopoulos, Joanna Bojarska, Tsun-Thai Chai, Sherif Elnagdy, Krzysztof Kaczmarek, John Matsoukas, Roger New, Keykavous Parang, Octavio Paredes Lopez, Hamideh Parhiz, Conrad O. Perera, Monica Pickholz, Milan Remko, Michele Saviano, Mariusz Skwarczynski, Yefeng Tang, Wojciech M. Wolf, Taku Yoshiya, Janusz Zabrocki, Piotr Zielenkiewicz, Maha Alkhazindar, Vanessa Barriga, Konstantinos Kelaidonis, Elham Mousavinezhad Sarasia, Istvan Toth

Pharmacy Faculty Articles and Research

Peptides are fragments of proteins that carry out biological functions. They act as signaling entities via all domains of life and interfere with protein-protein interactions, which are indispensable in bio-processes. Short peptides include fundamental molecular information for a prelude to the symphony of life. They have aroused considerable interest due to their unique features and great promise in innovative bio-therapies. This work focusing on the current state-of-the-art short peptide-based therapeutical developments is the first global review written by researchers from all continents, as a celebration of 100 years of peptide therapeutics since the commencement of insulin therapy in the 1920s. …

Analysis Of Broadest Impact Implementation For A Developing Point Of Care Device Using Antibody Antigen Reactions, Sienna Dugan, Gabrielle J. Gonzales, Kelly Little

SMU Journal of Undergraduate Research

With the recent launch of the Global Development Lab in the Hunter and Stephanie Hunt Institute for Engineering and Humanity, fellows, faculty, and industry professionals have been working to create meaningful solutions to promote a resilient humanity, addressing the UN’s Sustainable Development Goals and challenges. The Institute has taken on Dr. Ali Beskok’s project, the development of a low cost, portable, Point-of-Care-Device for humanitarian and health applications. This paper provides a systematic review of current Point-of-Care-Devices using antibody antigen reactions. Additionally, it provides aspects of a market analysis and a literature review. Its overarching goal is to make recommendations regarding …

Molecular Strategies To Overcome Antibiotic Resistance, Luting Fang

Arts & Sciences Graduate Student Theses and Dissertations

Antibiotics have greatly reduced the number of deaths caused by infectious diseases for the last 70 years, but as a result of overuse, antimicrobial resistance emerged. Resistance is the major reason why most traditional antibiotics currently have reduced clinical efficacy. However, there is still a drive to overcome this resistance in a variety of ways. There are two main avenues of research to overcome resistance; to discover and develop new drug candidates acting on new targets and pathways, and to determine the mechanisms of antibiotic resistance in order to combat it through multi-drug therapies, bringing back the effectiveness of antibiotics …

Investigating The Integration-Independent Role Of Hiv-1 In In The Viral Life Cycle, Jennifer Elliott

Arts & Sciences Graduate Student Theses and Dissertations

Human immunodeficiency virus type 1 (HIV-1) relies on a handful of essential enzymes for replication. Among these, the viral integrase enzyme (IN) plays a pivotal role in the viral life cycle by catalyzing the integration of the reverse-transcribed viral DNA into the host chromosome. While integration is the canonical role of IN, new research has uncovered an additional vital role for IN during virion morphogenesis. This dissertation elucidates how IN contributes to proper packaging of the viral RNA genome (vRNA) within the viral capsid and examines the fate of improperly formed viral particles in target cells.IN is proposed to mediate …

Understand And Predict Microbiome And Resistome Dynamics In Response To Perturbations Across Diverse Populations And Environments, Manish Boolchandani

Arts & Sciences Graduate Student Theses and Dissertations

Complex microbial communities are at the interface of human, animal and environment interconnected ecosystem, where they can move within and between these entities. These microbial communities are mostly beneficial, maintaining the host health and homeostatic state. However, these communities can also serve as reservoirs of antibiotic resistance (AR) genes that may disseminate to pathogen bacteria, compromising the treatment options. Like other microbial communities, human gut microbiome is highly dynamic and can get acutely perturbed with the changes in the habitat, diet, lifestyle and disease. A perturbed gut community structure has profound impact on the host health and physiology. Use of …

The Roles Of Plasmepsins Ix And X In Malaria Parasite Biology, Armiyaw Sebastian Nasamu

Arts & Sciences Graduate Student Theses and Dissertations

Proteases of the malaria parasite Plasmodium falciparum have been targeted for drug discovery for decades. The P. falciparum genome encodes ten aspartic proteases called plasmepsins, which are involved in diverse cellular processes. In this work we address the roles of two of these plasmepsins, plasmepsins IX and X (PM IX and X), the two least studied aspartic proteases in blood stage malaria parasites till date. We explore the essentiality of these proteases in parasite development, attempt to identify their substrates and the ability to drug them. We show that PM IX is essential for erythrocyte invasion, acting on rhoptry secretory …

Dispersal And Land Cover Contribute To Pseudorabies Virus Exposure In Invasive Wild Pigs, Felipe A. Hernandez, Amanda N. Carr, Michael P. Milleson, Hunter R. Merrill, Michael L. Avery, Brandon M. Parker, Cortney L. Pylant, James D. Austin, Samantha M. Wisely

United States Department of Agriculture Wildlife Services: Staff Publications

We investigated the landscape epidemiology of a globally distributed mammal, the wild pig (Sus scrofa), in Florida (U.S.), where it is considered an invasive species and reservoir to pathogens that impact the health of people, domestic animals, and wildlife. Specifically, we tested the hypothesis that two commonly cited factors in disease transmission, connectivity among populations and abundant resources, would increase the likelihood of exposure to both pseudorabies virus (PrV) and Brucella spp. (bacterial agent of brucellosis) in wild pigs across the Kissimmee Valley of Florida. Using DNA from 348 wild pigs and sera from 320 individuals at 24 sites, we …

Evaluating Research Support Facilities To University Students During Covid-19, Muhammad Shoaib, Dr. Shamshad Rasool, Dr. Behzad Anwar

Library Philosophy and Practice (e-journal)

This study aimed to examine the research support and availability of print resources to university students during COVID-19 in Pakistan. Along with other pandemic related issues during the lockdown, university students faced study issues as all the teaching activities were shifted to online, and they faced unavailability of print resources. A quantitative study design was opted to conduct the study. A total of 2745 university students participated in the survey. This form was sent to 5950 students through their emails and WhatsApp groups. A well-structured questionnaire was constructed and pre-tested from 30 randomly selected students. The study findings showed that …

The Increasing Significance Of Religious Tourism: A Case From Uttar Pradesh, India, Aruna Dhamija

International Journal of Religious Tourism and Pilgrimage

Tourism, in its numerous forms is a major source of income for various nations. India is no exception to this. Within some countries, a few states bring the major chunk of tourists. Uttar Pradesh is one such state for India which, on the virtue of its diversity, population and geographical size, has been at the forefront of attracting tourists from not only the country but globally. There has been a consistent shift in the profile of visiting tourists as they have displayed a marked change from those seeking recreational activities to those who visit a tourist destination owing to its …

Vaccine Update, January 13, 2021, University Of Northern Iowa

UNI Response to COVID-19

An update to the vaccination plan after the Iowa Infectious Disease Advisory Council did not include higher education institutions in the definiiton of educational sector employees, and therefore not included in Phase 1b.

January 13, 2021 Greenmail, University Of Alabama At Birmingham

GreenMail (student newsletter through 2024)

No abstract provided.

Working With Communities: Rural And Urban Underserved Program Scholars Take On Broader Health Issues Working With Communities, Crystal Krabbenhok, Jesse Barnes, A Carolyn Ice, Claire Sava, Tenzin Desel, Robert Williams

HSC Education Days

Clinicians in medically underserved communities encounter both community-wide health issues and community strengths. Together these raise the opportunities and responsibilities for clinicians to take action outside the clinical exam room to improve health in the community. Rural and Urban Underserved Program (RUUP) Scholars develop skills through engagement with communities in: 1) Health related advocacy, 2) Volunteer clinical care, 3) Health education pipeline support, 4) Non-clinical public health based community work, and/or 5) Community health education. Emphasis is on meaningful yet practical ways of partnering with others to work toward improved health goals. Students are encouraged to choose projects which take …

2021-01-13_Michiganoverview_Covidtestingtimes, Michigan Department Of Health & Human Services

Michigan COVID-19 Testing Turnaround Data

The COVID Testing Turnaround Time page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-545615--,00.html.

This report was created by the Michigan Department of Health & Human Services, providing data for the past 14 days on the average time it takes for a diagnostic COVID-19 laboratory test to be reported to the state health department. Testing turnaround time data will be updated weekly on Friday mornings.

MDHHS receives results from commercial labs, hospitals, and public health labs. However, public health laboratories perform limited diagnostic testing and disease surveillance for infectious diseases. Total turnaround time is calculated from the difference of …

Rsif Weekly Vol.2 No.1 - Happy New Year!, Regional Scholarship And Innovation Fund (Rsif)

Rsif Newsletters

No abstract provided.