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Isolation And Quantification Of Flavonoids From Kigelia Africana (Lam.) Benth Fruit And Bark And Their Antiradical And Antibacterial Activities, Pamhidzai Dzomba, George Mhini

Tanzania Journal of Science

Kigelia africana is an evergreen deciduous tree used in Zimbabwe folklore medicine for wound and diabetes ulcers healing. This paper reports the isolation and quantification of flavonoids from stem barks and fruits of K. africana as well as their antibacterial and antiradical activities. Flavonoids in ethanol and ethyl-acetate extracts were quantified using UV-Vis spectrophotometry and were found to be 213.490 ± 0.001 mg/L and 36.614 ± 0.001 mg/L, respectively per quercetin equivalent. The preparative and analytical thin layer chromatography was used to profile the flavonoids from fruits and barks using ethyl-acetate and petroleum ether (3:7 v/v) mobile solvent systems. Ethanol …

Influence Of Covid-19 On The Psychological Wellbeing Of Tertiary Institution Students In Nigeria, Seun Akorede, Ayodotun Ajayi, Atanda Toyin, Gilbert Uwadia

Tanzania Journal of Science

The outbreak of COVID-19 has led to a global lockdown, pending the time medical researchers find a vaccine for the coronavirus. This study examined if loneliness, depression and stress are influences of COVID-19 on the psychological wellbeing of tertiary institutions students in Nigeria. A descriptive research design of survey type was employed for this study. The population comprised all students of tertiary institutions in Nigeria totaling about 4,406,000. One hundred and thirty-seven (137) respondents were sampled for the study. A validated researcher developed questionnaire tested for reliability was used for the study. The data collected were analyzed using descriptive statistics. …

Hiv/Aids Transmission Dynamics: Modelling The Roles Of Long Distance Truck Drivers, Nyimvua Mbare

Tanzania Journal of Science

A mathematical model to investigate the roles of long distance truck drivers on HIV transmission dynamics was formulated and analyzed to establish the existence of disease free and endemic equilibrium points. The results show that, the disease free equilibrium point is asymptotically stable when the basic reproduction number is less than unity and unstable otherwise. Furthermore, comprehensive analyses on the two steady states (infection free and endemic) have shown that they are both globally and asymptotically stable. Sensitivity analysis is performed on the reproduction number in order to establish the relative importance of parameters, and it shows that the truck …

Campylobacteriosis Transmission Dynamics In Humans: Modeling The Effects Of Public Health Education, Treatment, And Sanitation, Furaha Chuma, Zubeda Mussa

Tanzania Journal of Science

An epidemic model for the dynamics of campylobacteriosis disease with public health education, treatment, and sanitation control strategies was formulated and analyzed. The stabilities of the equilibrium points were analyzed by using the Routh-Hurwitz criterion. The effective reproduction number was computed by using the Next Generation Matrix method. Numerical simulations were carried out and the results showed that, public health education has a substantial influence on the reduction of the effective reproduction number. Moreover, treatment and sanitation control strategies have also shown significant reduction of infected individuals from the respective population.Keywords: Campylobacteriosis; public health education; treatment; sanitation.

Mapping The Literature On Health Literacy Related To Covid-19 Pandemic: A Scientometric Analysis, Rozeen Shaukat, Nusrat Ali, Muhammad Asif Naveed

Library Philosophy and Practice (e-journal)

This study intended to carry out a scientometric analysis of the literature on health literacy related to Covid-19 pandemic and infodemic to determine its periodic growth, publication format dispersion, core journals, authorship patterns, geographic origin, keywords patterns, and core institutions. Two general bibliographic databases such as Scopus and Web of Science were searched using keywords such as ‘health literacy, health education, health communication, health promotion, combining with Covid-19 using AND to identify related citations. The data set of 620 citations were analyzed and visualized for several bibliographic characteristics using ScientoPy and VOSviewer. The results revealed that there is a phenomenal …

A Matter Of Life Or Death: Productively Infected And Bystander Cd4 T Cells In Early Hiv Infection, Dechao Cao, Sushant Khanal, Ling Wang, Zhengke Li, Juan Zhao, Lam N. Nguyen, Lam N. Nguyen, Xindi Dang, Madison Schank, Bal K. C. Thakuri, Jinyu Zhang, Zeyuan Lu, Xiao Y. Wu, Zheng D. Morrison, Mohamed El Gazzar, Shunbin Ning, Jonathan P. Moorman, Zhi Q. Yao

ETSU Faculty Works

CD4 T cell death or survival following initial HIV infection is crucial for the development of viral reservoirs and latent infection, making its evaluation critical in devising strategies for HIV cure. Here we infected primary CD4 T cells with a wild-type HIV-1 and investigated the death and survival mechanisms in productively infected and bystander cells during early HIV infection. We found that HIV-infected cells exhibited increased programmed cell death, such as apoptosis, pyroptosis, and ferroptosis, than uninfected cells. However, productively infected (p24+) cells and bystander (p24-) cells displayed different patterns of cell death due to differential expression of pro-/anti-apoptotic proteins …

Immunomodulatory Effects Of Azithromycin Revisited: Potential Applications To Covid-19, Vincent J. Venditto, Dalia Haydar, Ahmed K. Abdel-Latif, John C. Gensel, Michael I. Anstead, Michelle G. Pitts, Jarrod W. Creameans, Timothy J. Kopper, Chi Peng, David J. Feola

Pharmaceutical Sciences Faculty Publications

The rapid advancement of the COVID-19 pandemic has prompted an accelerated pursuit to identify effective therapeutics. Stages of the disease course have been defined by viral burden, lung pathology, and progression through phases of the immune response. Immunological factors including inflammatory cell infiltration and cytokine storm have been associated with severe disease and death. Many immunomodulatory therapies for COVID-19 are currently being investigated, and preliminary results support the premise of targeting the immune response. However, because suppressing immune mechanisms could also impact the clearance of the virus in the early stages of infection, therapeutic success is likely to depend on …

Integrated Plasma Proteomic And Single-Cell Immune Signaling Network Signatures Demarcate Mild, Moderate, And Severe Covid-19, Dorien Feyaerts, Julien Hedou, Joshua Gillard, Han Chen, Eileen S. Tsai, Laura S. Peterson, Kazuo Ando, Monali Manohar, Evan Do, Gopal K.R. Chinthrajah, Christopher M. Warren, Rich Wittman, Justin G. Meyeroqitz, Edward A. Ganio, Ina A. Stelzer, Xiaoyuan Han, Franck Verdonk, Dyani K. Gaudilliere, Nilanjan Mukherjee, Amy S. Tsai, Kristen K. Rumer, Sizun Jiang, Sergio Ivan Valdes Ferrer, J. Daniel Kelly, David Furman, Nima Aghaeepour, Martin S. Angst, Scott D. Boyd, Benjamin A. Pinsky, Garry P. Nolan, Kari C. Nadeau, Brice Gaudilliere, David R. Mcilwain

All Dugoni School of Dentistry Faculty Articles

The biological determinants of the wide spectrum of COVID-19 clinical manifestations are not fully understood. Here, over 1400 plasma proteins and 2600 single-cell immune features comprising cell phenotype, basal signaling activity, and signaling responses to inflammatory ligands were assessed in peripheral blood from patients with mild, moderate, and severe COVID-19, at the time of diagnosis. Using an integrated computational approach to analyze the combined plasma and single-cell proteomic data, we identified and independently validated a multivariate model classifying COVID-19 severity (multi-class AUCtraining = 0.799, p-value = 4.2e-6; multi-class AUCvalidation = 0.773, p-value = 7.7e-6). Features of this high-dimensional model recapitulated …

An Oncolytic Adenovirus Encoding Sa-4-1bbl Adjuvant Fused To Hpv-16 E7 Antigen Produces A Specific Antitumor Effect In A Cancer Mouse Model, Alejandra G. Martinez-Perez, Jose J. Perez-Trujillo, Rodolfo Garza-Morales, Norma E. Ramirez-Avila, Maria J. Loera-Arias, Jorge G. Gomez-Gutierrez, Odila Saucedo-Cardenas, Aracely Garcia-Garcia, Humberto Rodriguez-Rocha, Roberto Montes-De-Oca-Luna

School of Medicine Publications

Human papillomaviruses (HPVs) are responsible for about 25% of cancer cases worldwide. HPV-16 E7 antigen is a tumor-associated antigen (TAA) commonly expressed in HPV-induced tumors; however, it has low immunogenicity. The interaction of 4-1BBL with its receptor induces pleiotropic effects on innate, adaptive, and regulatory immunity and, if fused to TAAs in DNA vaccines, can improve the antitumor response; however, there is low transfection and antitumor efficiency. Oncolytic virotherapy is promising for antitumor gene therapy as it can be selectively replicated in tumor cells, inducing cell lysis, and furthermore, tumor cell debris can be taken in by immune cells to …

Areas Of Metabolomic Exploration For Helminth Infections, Jeffrey D Whitman, Judy A Sakanari, Makedonka Mitreva

2020-Current year OA Pubs

Helminths represent a diverse category of parasitic organisms that can thrive within a host for years, if not decades, in the absence of treatment. As such, they must establish mechanisms to subsist off their hosts, evade the immune system, and develop a niche among the other cohabiting microbial communities. The complex interplay of biologically small molecules (collectively known as the metabolome) derived from, utilized by, or in response to the presence of helminths within a host is an emerging field of study. In this Perspective, we briefly summarize the current existing literature, categorize key host-pathogen-microbiome interfaces that could be studied …

February 12, 2021 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Covid 19 Information Seeking Behaviour Of Internally Displaced Persons (Idps) In The Federal Capital Territory, Abuja, Nigeria, Ademola Ferdinand Omosekejimi Mr, Grace Arerosuoghene Dada Mrs, Sylvester Israel Ebhonu Mr

Library Philosophy and Practice (e-journal)

This study focused on exploring COVID 19 information seeking behavior of IDPs Nigerian using IDPs in the federal capital territory, Abuja, Nigeria as a case study. The study adopted a descriptive survey design. Four objectives were laid down for the study and a structured questionnaire was used to elicit information from the respondents. The findings revealed that the COVID 19 information needs of IDPs are information on symptoms of COVID 19, how it spreads, preventive measures against COVID 19, the causes of COVID 19 and how to get medical attention should anyone be confirmed infected at the IPD camp among …

The Increased Exposure To Coronavirus (Covid-19) For Prisoners Justifies Early Release: And The Wider Implications Of This For Sentencing—Reducing Most Prison Terms Due To The Harsh Incidental Consequences Of Prison, Mirko Bagaric, Peter Isham, Jennifer Svilar

Pepperdine Law Review

The risk of coronavirus (COVID-19) spreading in prisons is especially acute. This has resulted in an unprecedented number of prisoners being released across the world – including many prisoners in the United States. From the health, social, and political perspectives, this is a sound approach. This is especially the situation in relation to older prisoners and those who have not been imprisoned for serious sexual and violent offenses. Despite the large number of prisoners that are being released, the United States will still have the largest prison population on earth—and by a large margin. However, the coronavirus pandemic and the …

New Innovation Models In Medical Ai, Nicholson Price Ii, Rachel Sachs, Rebecca S. Eisenberg

Law & Economics Working Papers

In recent years, scientists and researchers have devoted considerable resources to developing medical artificial intelligence (AI) technologies. Many of these technologies—particularly those which resemble traditional medical devices in their functions—have received substantial attention in the legal and policy literature. But other types of novel AI technologies, such as those that relate to quality improvement and optimizing use of scarce facilities, have been largely absent from the discussion thus far. These AI innovations have the potential to shed light on important aspects of health innovation policy. First, these AI innovations interact less with the legal regimes that scholars traditionally conceive of …

Outcomes Of Patients With Thrombocytopenia Evaluated At Hematology Subspecialty Clinics, Zaid H. Abdel-Rahman, Kevin C. Miller, H Jabbour, Yaser Alkhatib, Vijayalakshmi Donthireddy

Hematology/Oncology Articles

BACKGROUND: Thrombocytopenia is a frequently encountered laboratory abnormality and a common reason for hematology referrals. Workup for thrombocytopenia is not standardized and frequently does not follow an evidence-based algorithm. We conducted a systematic analysis to evaluate the laboratory testing and outcomes of patients evaluated for thrombocytopenia at hematology clinics in a tertiary referral center between 2013 and 2016.

PATIENT AND METHODS: We performed a comprehensive chart review for patients evaluated for thrombocytopenia during the study period. Patients were followed for 1 year from the initial hematology evaluation and assessed for the development of a hematologic malignancy, rheumatologic, or infectious diseases …

The Lived Experience Of Syrian Refugees In Canada: A Phenomenological Study, Khaldoun Aldiabat, Enam Alsrayheen, Catherine Aquino-Russell, Michael Clinton, Roger Russell

The Qualitative Report

Health care providers in Canada are expected to take care of people from a variety of cultural backgrounds, and it is difficult for health care providers to deeply understand the lived experiences of some individuals to provide them with culturally sensitive care. Syrian refugees comprise one such group of newcomers to Canada. This phenomenological study aimed to uncover the meaning of the lived experiences of Syrian refugees using Giorgi’s (2009) method. Seven participants’ descriptions were viewed through the lens of the social determinants of health model. Seven essences of the general structural description or the meaning Syrian refugees gave to …

Current Practice Of Oral Care For Hematopoietic Stem Cell Transplant Patients: A Survey Of The Eastern Mediterranean Blood And Marrow Transplantation Group, Hani Mawardi, Nathaniel Treister, Osama Felemban, Waleed Alamoudi, Ghada Algohary, Abdulrahman Alsultan, Nawal Alshehri, Illias Tazi, Marwan Shaheen, Natasha Bahadur Ali

Section of Haematology/Oncology

Introduction: The oral cavity is one of the most common sites impacted by hematopoietic stem cell transplantation (HSCT) with acute complications including mucositis, bleeding, salivary gland dysfunction, infection, and taste alteration. These complications may result in significant morbidity and can negatively impact outcomes such as length of stay and overall costs. As such, oral care during HSCT for prevention and management of oral toxicities is a standard component of transplant protocols at all centers. The objective of this study was to evaluate the current oral care practices for patients during HSCT at different transplant centers within the Eastern Mediterranean region. …

Post-Pandemic, Translational Research, And Indigenous Communities, Rodney C. Haring, Laticia Mcnaughton, Dean S. Seneca, Whitney Ann E. Henry, Donald Warne

Journal of Indigenous Research

It is well documented that American Indian/Alaska Native/Native Hawaiian/First Nations, known as Indigenous Peoples, have among the most significant health disparities in the world. Clinical services for these populations are typically underfunded, and Indigenous Peoples often have preexisting and co-occurring health conditions. These factors combined with a multitude of social inequities make Indigenous communities extremely susceptible to infectious diseases, including COVID- 19. This paper discusses perspectives on the post-pandemic frameworks and policies toward translational science as an approach to advance health promotion for community-based interventions, dissemination, and sustainability. The importance of exercising Indigenous self-determination, public health authority, and population health …

February 10, 2021: Covid-19 Campus Update, Kettering University

Communication Updates

In an ongoing effort to keep our campus safe, the University will implement new Randomized COVID-19 Sampling Testing for all students, faculty, and staff beginning February 15

2021-02-10_Michiganoverview_Covidtestingtimes, Michigan Department Of Health & Human Services

Michigan COVID-19 Testing Turnaround Data

The COVID Testing Turnaround Time page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-545615--,00.html.

This report was created by the Michigan Department of Health & Human Services, providing data for the past 14 days on the average time it takes for a diagnostic COVID-19 laboratory test to be reported to the state health department. Testing turnaround time data will be updated weekly on Friday mornings.

MDHHS receives results from commercial labs, hospitals, and public health labs. However, public health laboratories perform limited diagnostic testing and disease surveillance for infectious diseases. Total turnaround time is calculated from the difference of …

Covid-19 And Children: What Parents Need To Know, Caleb Jones

Browse All News

No abstract provided.

Parker High School Covid Vaccination Site Set To Open Thursday, Tyler Greer

Browse All News

No abstract provided.

2021-February-10-Quillen College Of Medicine Students Gain Covid- Research Experience, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY (Feb. 10, 2021) – A summer research program at East Tennessee State University’s Quillen College of Medicine led to an opportunity for medical students to gain COVID-19 research experience.

Dr. Donald Hoover, professor in the Department of Biomedical Sciences, mentored two second-year medical students, Fulton Robinson and Ryan Mihealsick, during Quillen’s Medical Student Summer Research Program held last summer. The students had the opportunity to participate in the conception, planning, implementation and publication of research focusing on cardiac morbidity and mortality related to COVID-19 infection.  

Their mini-review, “Role of angiotensin-converting enzyme 2 and pericytes in cardiac complications of …

2021-02-10_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

The Impact Of Covid-19 On The Standard & Poor 500 Index Sectors: A Multivariate Generalized Autoregressive Conditional Heteroscedasticity Model, Maha Elhini, Rasha Hammam

Economics

Purpose – This paper aims to examine the impact of the daily growth rate of COVID-19 cases in the USA (COVID), the Federal Fund Rate (FFR) and the trade-weighted US dollar index (USDX) on S&P500 index daily returns and its 11 constituent sectors’ indices for the time period between January 22, 2020, until June 30, 2020. Design/methodology/approach – The study uses the multivariate generalized autoregressive conditional heteroscedasticity (MGARCH) model to gauge the impacts over the whole period of study, as well as over two sub-periods; first, January 22, 2020, until March 30, 2020, reflecting uncertainty in the US markets and …

System For Preventing Airborne Transmission Of Covid-19 In Schools, Offices, And Similar Venues, Edward Bullister

Defensive Publications Series

System for Preventing Airborne Transmission of COVID-19 in Schools, Offices, and Similar Venues

The invention describes systems to isolate and collect the exhaled aerosols that are the primary mechanism of transmission COVID-19.

The segregation of exhalants enables people to meet together in a shared space and breathe shared air without transmitting pathogens amongst themselves. A set of barriers and vents are configured to corral and collect exhaled air to direct the exhalant (along with its COVID-containing aerosols) to be filtered by purifiers or by a building’s heating, ventilation, and A/C (HVAC) system.

These barriers and vents can make air purifiers …

Ua12/2/1 College Heights Herald, Vol. 96, No. 17, Wku Student Affairs

WKU Administration Documents

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news. This issue contains articles:

• Tolbert, Ellie. Student Teaching Transforms to Allow Virtual Instruction
• Murray, Debra. Provost Reflects on Time at WKU, As an Educator as She Prepares for Retirement – Cheryl Stevens
• Gaskin, Loren. Up for Debate: Potter College Name Change
• Meyer-Thornton, Zane & Jack Dobbs. The Sixth Annual Puppy Bowl
• Snyder, Sean. Local Doctor Finds Life-long Passion in Race-walking – Doug Johnson
• Toennies, Drew. Lady Toppers Travel to Face Top Conference Foe Rice – Basketball
• Snyder, Sean. Lady Toppers to Host Bellarmine for Home Opener – Soccer
• Moore, …

Modalities, Challenges, And Possibilities: An Introduction To The Pharmaceutical Innovation Symposium, Peter K. Yu

Texas A&M Journal of Property Law

On October 25, 2019, the Texas A&M Journal of Property Lawand the Center for Law and Intellectual Property at Texas A&M University School of Law jointly organized the “Pharmaceutical Innovation, Patent Protection, and Regulatory Exclusivities” Symposium. Although none of the organizers and participants could predict what was to come in the next few months, there was a wide consensus that the rapid changes in the pharmaceutical landscape and our continuous struggle to strike a proper balance between proprietary protection and public access in the public health arena deserves scholarly, policy, and regulatory attention.

To help contextualize the articles included in …

2021-02-09_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

The Worst Is Behind Us: News Media Choice And False Optimism In The Summer Of 2020, Lawrence C. Hamilton, Thomas G. Safford

Faculty Publications

In the summer of 2020, mitigation efforts slowed the first US wave of the COVID-19 pandemic. Experts warned, however, that without coordinated, sustained mitigation—such as testing and tracing, limited travel or gatherings, social distancing and mask wearing—the worst could lie ahead. A July survey found majority (59%) agreement with the expert warnings, while a minority (27%) mistakenly thought that the worst was behind us, or that COVID-19 was not a real problem. Among frequent Fox News and conservative talk radio consumers, however, large majorities (67–80%) held such false optimism or denial views, in contrast with small minorities (9–16%) among public …