Digital Commons Network^™

Inhibition Of Zika Virus Replication By G-Quadruplex-Binding Ligands, Indian Institute Of Technology Indore, Aryamav Pattnaik, Bikash R. Sahoo, Uma Shankar, Asit K. Pattnaik, Amit Kumar, Debasis Nayak

Nebraska Center for Virology: Faculty Publications

Zika virus (ZIKV), a mosquito-transmitted Flavivirus, emerged in the last decade causing serious diseases and affecting human health globally. Currently, no licensed vaccines or antivirals are available to combat ZIKV, although several vaccine candidates are in the pipeline. In recent years, the presence of non-canonical G-quadruplex (GQ) secondary structures in viral genomes has ignited significant attention as potential targets for antiviral strategy. In this study, we identified several novel conserved potential GQ structures by analyzing published ZIKV genome sequences using an in-house algorithm. Biophysical and biochemical analysis of the RNA sequences containing these potential GQ sequences suggested the existence of …

Great Expectations: Deconstructing The Process Pathways Underlying Beaver-Related Restoration, Caroline S. Nash, Gordon E. Grant, Susan Charnley, Jason B. Dunham, Hannah Gosnell, Mark B. Hausner, David S. Pilliod, Jimmy Taylor

United States Department of Agriculture Wildlife Services: Staff Publications

Beaver-related restoration is a process-based strategy that seeks to address wide-ranging ecological objectives by reestablishing dam building in degraded stream systems. Although the beaver-related restoration has broad appeal, especially in water-limited systems, its effectiveness is not yet well documented. In this article, we present a process-expectation framework that links beaver-related restoration tactics to commonly expected outcomes by identifying the set of process pathways that must occur to achieve those expected outcomes. We explore the contingency implicit within this framework using social and biophysical data from project and research sites. This analysis reveals that outcomes are often predicated on complex process …

Privacy-Preserving Federated Deep Learning With Irregular Users, Guowen Xu, Hongwei Li, Yun Zhang, Shengmin Xu, Jianting Ning, Robert H. Deng

Research Collection School Of Computing and Information Systems

Federated deep learning has been widely used in various fields. To protect data privacy, many privacy-preserving approaches have also been designed and implemented in various scenarios. However, existing works rarely consider a fundamental issue that the data shared by certain users (called irregular users) may be of low quality. Obviously, in a federated training process, data shared by many irregular users may impair the training accuracy, or worse, lead to the uselessness of the final model. In this paper, we propose PPFDL, a Privacy-Preserving Federated Deep Learning framework with irregular users. In specific, we design a novel solution to reduce …

March 2021 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Identification Of Caligus Parasites Infesting Morone Labrax And Its Impact On Fish Health Status And Pathological Alteration., Nevien Kamel Abdelkhalek, Rehab Abd El Maged, Hanaa Ali, Neveen Satour

Mansoura Veterinary Medical Journal

Objective: The present study was aimed to investigate sea lice infestation including morphometric, molecular identification, disease prevalence and pathological tissue alterations in wild Sea bass (Morone Labrax) naturally collected from Ezbet Elborg, Damietta province, Egypt from October 2018 to end of August 2019. Design: Descriptive study Fish: 120 wild seabass (Morone Labrax) Procedures: The collected fish from Ezbet Elborg area, Damietta province, Egypt were clinically and parasitological investigated for the prevalence of sea lice parasite with molecular identification of the collected parasite samples with study of the pathological alteration of the affected tissue. Results: The study revealed that 48 fish …

Ringworm In Dogs, Ahmed Hesham, Samar Atwa

Mansoura Veterinary Medical Journal

Dermatophytosis is a common self limiting zoonotic fungal disease which coused by infection of certain types of dermatophyte (1,2).that fungi of 3 fundamental genera specifically, Microsporum, Trichophyton and epidermophyton. We wont wait its self limiting cause it Causes economic losses. That disease spread fastly amoung all existing dogs and may be owners. And take an extended time in treatment. Dermatophytosis is generally called as ringworm. And that is visibly portrayed by multi-focal alopecia and hulls on the skin with a selected formation (3,4). This infection has gained specific attention publicly health, because it distributed all over the world. After touching …

Change In Outbreak Epicentre And Its Impact On The Importation Risks Of Covid-19 Progression: A Modelling Study, Oyelola A. Adegboye, Adeshina I. Adekunle, Anton Pak, Ezra Gayawan, Denis H. Y. Leung, Diana P. Rojas, Emma S. Mcbryde, Damon P. Eisen

Research Collection School Of Economics

Background: The outbreak of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) that was first detected in the city of Wuhan, China has now spread to every inhabitable continent, but now the attention has shifted from China to other epicentres. This study explored early assessment of the influence of spatial proximities and travel patterns from Italy on the further spread of SARS-CoV-2 worldwide. Methods: Using data on the number of confirmed cases of COVID-19 and air travel data between countries, we applied a stochastic meta-population model to estimate the global spread of COVID-19. Pearson's correlation, semi-variogram, and Moran's Index were used to …

Highly Used Journals In 2020, Joanne Romano

TMC Library Newsletter (2015-)

The most popular journal used in 2020 was Nature, with 12,954 requests, followed by Science and Nature Medicine..

Cases Of Neuromyelitis Optica Spectrum Disorder From The East Africa Region, Highlighting Challenges In Diagnostics And Healthcare Access, Dilraj Sokhi, Adil Suleiman, Soraiya Manji, Juzar Hooker, Peter Mativo

Internal Medicine, East Africa

Background: Neuromyelitis optica spectrum disorder (NMOSD) is an auto-immune disease of the central nervous system (CNS) associated with the IgG-antibody against aquaporin-4 (AQP4-IgG). There is little published epidemiology of NMOSD from sub-Saharan Africa (SSA).

Methods: We retrospectively collated NMOSD cases admitted to our tertiary regional neurology centre.

Results: We identified 11 cases (10 female, average age 30 years). 64% (7/11) were seropositive for AQP4-IgG, measured using indirect immunofluorescence. The remaining cases could either not afford tests, or had patho-gnomonic radiological features. 57% (4/7) of seropositive cases had concurrent/recent CNS infection. All pa-tients were treated with high-dose intravenous …

Impact Of Sampling Depth On Pathogen Detection In Pit Latrines., Drew Capone, Petros Chigwechokha, Francis L. De Los Reyes, Rochelle H. Holm, Benjamin B. Risk, Elizabeth Tilley, Joe Brown

Faculty and Staff Scholarship

Wastewater based epidemiology (WBE) is increasingly used to provide decision makers with actionable data about community health. WBE efforts to date have primarily focused on sewer-transported wastewater in high-income countries, but at least 1.8 billion people in low-and middle-income countries (LMIC) use onsite sanitation systems such as pit latrines and septic tanks. Like wastewater, fecal sludges from such systems offer similar advantages in community pathogen monitoring and other epidemiological applications. To evaluate the distribution of enteric pathogens inside pit latrines–which could inform sampling methods for WBE in LMIC settings unserved by sewers–we collected fecal sludges from the surface, mid-point, and …

Evaluation Of Serum Ferritin For Prediction Of Severity And Mortality In Covid-19- A Cross Sectional Study, Sibtain Ahmed, Zeeshan Ansar Ahmed, Imran Siddiqui, Naveed Haroon Rashid, Maheen Mansoor, Lena Jafri

Department of Pathology and Laboratory Medicine

Background: Ferritin even though widely recognized as a representative of total body iron stores, its prognostic utility is linked with COVID-19. This study was aimed at evaluation of the association of ferritin with severity in Coronavirus disease 2019 (COVID-19), hospitalized patients and to test the hypothesis that it is an independent predictor of mortality.
Material and methods: This study was conducted at Chemical Pathology, Department of Pathology and Laboratory Medicine, Aga Khan University (AKU), Karachi. Medical records of all in-patients including both genders, and all age groups with documented COVID-19 from 1st March to 10^th August 2020 were reviewed. …

Evolutionary Theory: Coping With A Pandemic., Lawrence C. Scharmann

Department of Teaching, Learning, and Teacher Education: Faculty Publications

Early in 2020, nations across the globe were warned about the potential for a pandemic arising from a novel virus that originated in Wuhan, China. The virus began an inevitable steady march of infection locally, regionally, nationally, and eventually internationally. Questions posed by infectious disease specialists were:

• Is the infectious disease one that is already known? Answer: no.

• Does the infectious disease (at the very least) closely resemble other known diseases? Answer – other than the virus possessing a distinguishing corona or halo when viewed under electron microscopy – no.

Thus, other than identifying the morphological shape of …

Mice Pups Breastfed By Foster Mothers Whose Breast Milk Contains Plasmodium Falciparum Recombinant Se36 Antigen Develop Specific Antibodies, Margaret Mendi Njoroge, Victor Irungu Mwangi, Tonny Jimmy Owalla, Hastings Ozwara, Thomas G. Egwang

All Peer-Reviewed Publications

Intranasal instillation of SE36, a malaria vaccine candidate antigen, in lactating BALB/c strain (derived from the Bagg and albino laboratory inbred mice) female mice resulted in the appearance of the antigen in breast milk as demonstrated by sandwich ELISA and Western blot. Pups born of immunologically naive mice and breastfed on lactating foster mothers exposed intranasally to SE36 developed IgG anti-SE36 antibodies. These data demonstrate that maternal immunization in mice by this route in lactating mothers can result in active immunization of offspring via ingestion of breast milk containing antigen. If confirmed in a nonhuman primate model and in human …

Understanding The Psychosocial Factors Affecting Prostate Cancer Screening In African Immigrant Men, Nipher M. Malika

Loma Linda University Electronic Theses, Dissertations & Projects

Prostate cancer(PCa) is the leading non-cutaneous cancer in men worldwide. Black men are disproportionately affected with a risk of 1 in 4 where they tend to develop PCa younger than most men, are diagnosed with a more aggressive disease, are more likely to advance to a higher metastatic state, and die at a higher rate than any other ethnic group. Age appropriate screening via the prostate-specific antigen test and digital rectal examination is critical and standard clinical practice, however, Black men have the lowest engagement in timely preventative health screenings and medical treatment. African-born immigrants are one of the fastest …

Ethical, Legal, And Social Issues (Elsi), Andrea Jerkovic´, Alexander Siedschlag

Publications

This chapter introduces the concept of ethical, legal, and social issues – known as ELSI – as it is relevant to security science research and security science-informed practice. After defining ethical, legal, and social issues, the chapter addresses main ELSI domains and discusses how to address those in security science. Arguments are illustrated using examples from domains such as critical infrastructure protection and novel coronavirus pandemic (COVID-19) response. Subsequently, the chapter demonstrates the relevance of ELSI analysis in security science for risk assessment and vulnerability analysis. It argues for a comprehensive approach to ELSI assessment and consideration in security science …

Noncompliance With Safety Guidelines As A Free-Riding Strategy: An Evolutionary Game-Theoretic Approach To Cooperation During The Covid-19 Pandemic, Jose C. Yong, Bryan K. C. Choy

Research Collection School of Social Sciences

Evolutionary game theory and public goods games offer an important framework to understand cooperation during pandemics. From this perspective, the COVID-19 situation can be conceptualized as a dilemma where people who neglect safety precautions act as free riders, because they get to enjoy the benefits of decreased health risk from others' compliance with policies despite not contributing to or even undermining public safety themselves. At the same time, humans appear to carry a suite of evolved psychological mechanisms aimed at curbing free riding in order to ensure the continued provision of public goods, which can be leveraged to develop more …

Is Covid-19 Pushing Us To The Fifth Industrial Revolution (Society 5.0)?, Zouina Sarfraz, Azza Sarfraz, Hamza M. Iftikar, Ramsha Akhund

Department of Paediatrics and Child Health

The coronavirus disease 2019 (COVID-19) pandemic may further promote the development of Industry 4.0 leading to the fifth industrial revolution (Society 5.0). Industry 4.0 technology such as Big Data (BD) and Artificial Intelligence (AI) may lead to a personalized system of healthcare in Pakistan. The final bridge between humans and machines is Society 5.0, also known as the super-smart society that employs AI in healthcare manufacturing and logistics. In this communication, we review various Industry 4.0 and Society 5.0 technologies including robotics and AI being inspected to control the rate of transmission of COVID-19 globally. We demonstrate the applicability of …

Impact Of Multiple Waves Of Covid-19 On Healthcare Networks In The United States, Emad M. Hassan, Hussam N. Mahmoud

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

The risk of overwhelming hospitals from multiple waves of COVID-19 is yet to be quantified. Here, we investigate the impact of different scenarios of releasing strong measures implemented around the U.S. on COVID-19 hospitalized cases and the risk of overwhelming the hospitals while considering resources at the county level. We show that multiple waves might cause an unprecedented impact on the hospitals if an increasing number of the population becomes susceptible and/or if the various protective measures are discontinued. Furthermore, we explore the ability of different mitigation strategies in providing considerable relief to hospitals. The results can help planners, policymakers, …

A Systematic Review On Improving Implementation Of The Revitalised Integrated Disease Surveillance And Response System In The African Region: A Health Workers' Perspective, Arthur K.S. Ng'etichi, Kuku Voyi, Ruth C. Kirinyet, Clifford M. Mutero

All Peer-Reviewed Publications

Background The revised integrated disease surveillance and response (IDSR) guidelines adopted by African member states in 2010 aimed at strengthening surveillance systems critical capacities. Milestones achieved through IDSR strategy implementation prior to adopting the revised guidelines are well documented; however, there is a dearth of knowledge on the progress made post-adoption. This study aimed to review key recommendations resulting from surveillance assessment studies to improve implementation of the revitalised IDSR system in the African region based on health workers' perspectives. The review focused on literature published between 2010 and 2019 post-adopting the revised IDSR guidelines in the African region. Methods …

The Structure And Diversity Of Strain-Level Variation In Vaginal Bacteria, Brett A Tortelli, Amanda L Lewis, Justin C Fay

2020-Current year OA Pubs

The vaginal microbiome plays an important role in human health and species of vaginal bacteria have been associated with reproductive disease. Strain-level variation is also thought to be important, but the diversity, structure and evolutionary history of vaginal strains is not as well characterized. We developed and validated an approach to measure strain variation from metagenomic data based on SNPs within the core genomes for six species of vaginal bacteria:

Initial Experience In Monitoring Qt Intervals Using A Six-Lead Contactless Mobile Electrocardiogram In An Inpatient Setting., Daniel Frisch, Eitan Frankel, Darius Farzad, Md, Sang H Woo, Alan Kubey

Division of Cardiology Faculty Papers

Mobile electrocardiograms (ECGs) (mECGs) using smartphone applications are an emerging technology. In the coronavirus disease 2019 (COVID-19) era, minimizing patient contact has gained increasing importance. Additionally, increased QT/corrected QT (QTc) monitoring has concurrently been required. The KardiaMobile 6L ECG device, cleared by the United States Food and Drug Administration (FDA) for recording ECGs, along with the KardiaStation tablet application is a platform (AliveCor, Mountain View, CA, USA) that addresses these two issues. A team of residents, fellows, hospitalists, and cardiologists identified inpatients in need of QT/QTc interval monitoring to pilot the adoption of a system composed of a KardiaMobile 6L …

A Facile High-Throughput Model Of Surface-Independent Staphylococcus Aureus Biofilms By Spontaneous Aggregation, Terrence Cheng, Nelson S. Torres, Ping Chen, Anand Srinivasan, Sandra Cardona, Grace C. Lee, Kai P. Leung, Jose L. Lopez-Ribot, Anand K. Ramasubramanian

Faculty Research, Scholarly, and Creative Activity

Many microbes in their natural habitats are found in biofilm ecosystems attached to surfaces and not as free-floating (planktonic) organisms. Furthermore, it is estimated that nearly 80% of human infections are associated with biofilms. Biofilms are traditionally defined as three-dimensional, structured microbial communities that are attached to a surface and encased in a matrix of exopolymeric material. While this view of biofilm largely arises from in vitro studies under static or flow conditions, in vivo observations have indicated that this view of biofilms is essentially true only for foreign-body infections on catheters or implants where biofilms are attached to the …

Scientometric Analysis And Visualization Of Astrovirus Based On R-Packages, Sivankalai S, Virumandi A, Sivasekaran K, Bala Sankar B, Balamurugan B, Sharmila M, Kaladevi P

Library Philosophy and Practice (e-journal)

We examined scientific production of the astroviruses study community done the past two decades in the worldwide. Scientometric methods, particularly the literature development models, Document types, Most Global Cited Documents, Most Frequent Words, Authors collaboration, Author Impact (h-index, g-index, m-index), Most Local Cited Authors, Relevant Countries by Corresponding Author, Most Cited Countries, Most Relevant Affiliations are identified. The results of this study confess that the scientific literature on astroviruses in worldwide had grown-up exponentially with an annual growth rate of about 8.86% during the above declared period. Journal of medical virology were the most productive journals contributing 71 articles of …

Does The Fibrinogen/Albumin Ratio Predict The Prognosis Of Pregnancies With Abortus Imminens?, Ceyda S. Usta, Tugba K. Atik, Ruhsen Ozcaglayan, Cagla B. Bulbul, Figen E. Camili, Ertan Adali

Saudi Medical Journal

Objectives: To investigate the fibrinogen/albumin ratio (FAR) of pregnant women with abortus imminens (AI) and its prognostic value for predicting spontaneous abortion. Methods: A total 102 early pregnancies, 52 had been diagnosed with AI and 50 ages and body mass index matched healthy control pregnant women were included in this prospective observational study conducted in the Research and Training Hospital, Balikesir University, Balikesir, Turkey between September 2019 and August 2020. Fibrinogen/albumin values were compared between AI and control group. Results: The rate of spontaneous abortion in AI pregnancies was 26.9% in our study population. Fibrinogen/albumin ratio levels were higher in …

Covid-19 In Children Ranging From Asymptomatic To A Multi-System Inflammatory Disease: A Single-Center Study, Walaa Shahin, Walaa Rabie, Osama Alyossof, Mohammed Alasiri, Mohamed Alfaki, Elamin Mahmoud, Muwaffak Hijazi, Huda El Faraidi, Hassan Alahmari

Saudi Medical Journal

Objectives: To identify clinical and laboratory characteristics of the Saudi children with confirmed COVID-19. Methods: Eighty-eight children (0-14 years) with COVID-19 who were admitted to Prince Sultan Military Medical City (PSMMC), Riyadh, Saudi Arabia from April to June 2020 were recruited. Results: Mean age was 5.74 ± 4.7 years with 41 (49.4%) males and 42 (50.6%) females. The length of hospital stay (LOS) ranged from 1 to 17 days. The main source of infection was infected family members. Mean values of C-reactive protein (CRP), serum ferritin, and lactate dehydrogenase (LDH) were noticeably above normal. Degree of severity and length of …

Health Care Worker Burnout During The Covid-19 Pandemic: A Cross-Sectional Survey Study In Saudi Arabia, Loui K. Alsulimani, Abdulrahman M. Farhat, Renad A. Borah, Jumanah A. Alkhalifah, Salman M. Alyaseen, Sumaeah M. Alghamdi, Malak J. Bajnaid

Saudi Medical Journal

Objectives: To estimate the prevalence of burnout among health care workers (HCWs) who are working in Saudi Arabia during the Coronavirus disease 2019 (COVID-19) pandemic, and explore individual and work-related factors associated with burnout in this population. Methods: In this cross-sectional study conducted between June to August of 2020, we invited HCWs through social channels to complete a questionnaire. The questionnaire inquired about demographics, factors related to burnout, and used the Copenhagen Burnout Inventory scale to indicate burnout. A total of 646 HCWs participated. Results: The mean (SD) age of participants was 34.1 (9.5) years. Sixty-one percent were female. The …

Growth In Global Research Productivity Of Virology Literature Over 10 Years: A Scientometric Study, Vishakha Sankar, R. Sarangapani

Library Philosophy and Practice (e-journal)

In order to expand upon the limited literature estimating the quantity and quality of worldwide research output in the field of virology, a bibliometric analysis was conducted for the period 2011-2020 using the web of science databases. The major focus was only growth perspective for example year wise productivity, Relative Growth rate, Annual growth rate, Compound growth rate, doubling time, Annual Ratio of growth, Exponential Growth rate, and Arithmetic mean over the years. It is found that India shared 2.46% of global publications. The RGR has been decreasing from 2012 (0.69) to 2020 (0.10) but other hand Doubling time increased …

Health Literacy Of The Covid-19 Pandemic On The Behavior Of Street Children’S Mothers In Indonesia, Yanti Tayo, Ninis Agustini Damayani, Atwar Bajari, Wawan Setiawan

Library Philosophy and Practice (e-journal)

The COVID-19 virus, which is spreading rapidly and massively around the world, is causing panic and fear in everyone; the Indonesian government is taking quick steps to solve the COVID 19 pandemic that is currently happening. What about the fate of street children currently still on the streets working as street singers, beggars, and hawkers? This study aims to see how health literacy possessed by the mothers of street children who are still on the streets during the COVID-19 pandemic. This study uses a qualitative research method with a phenomenological approach. The resource persons in this study were ten mothers …

Sars-Cov-2: Potencial Transmisión Feco-Oral E Implicaciones En La Propagación Y Gravedad Del Covid-19 En Venezuela. Mini-Revisión. [Sars-Cov-2: Potential Feco-Oral Transmission And Implications On The Spread And Severity Of Covid-19 In Venezuela. Mini-Review.], Leonor Chacin-Bonilla, Nathalie Chacon

School of Medicine Publications

The recognized human-to-human transmission of SARS-CoV-2 is through respiratory droplets and contact with contaminated surfaces. However, the high transmissibility of the virus and the pattern of symptoms of COVID-19 suggest the likelihood of other forms of spread. Increasing evidence suggests that SARS‐CoV‐2 could be transmitted by the feco‐oral route. SARS-CoV-2 is known to infect gastrointestinal epithelial cells and a significant number of infected people have gastrointestinal symptoms. Viable viruses, viral RNA, and prolonged shedding of viral RNA have been detected in the feces of COVID-19 patients. The virus has been found in sewage and surface waters of several countries. The …

Real-World Outcomes Of Direct-Acting Antiviral Treatment And Retreatment In United Kingdom–Based Patients Infected With Hepatitis C Virus Genotypes/Subtypes Endemic In Africa, Elihu Aranday-Cortes, C. Patrick Mcclure, Christopher Davis, William L. Irving, Kazeem Adeboyejo, Lily Tong, Silva Filipe A Da, Vattipally Sreenu, Kosh Agarwal, David Mutimer, Benjamin Stone, Matthew E. Cramp, Emma C. Thomson, Jonathan K. Ball, John Mclauchlan

Peninsula Medical School

Abstract Background Chronic hepatitis C virus (HCV) infection affects 71 million individuals, mostly residing in low- and middle-income countries (LMICs). Direct-acting antivirals (DAAs) give high rates of sustained virological response (SVR) in high-income countries where a restricted range of HCV genotypes/subtypes circulate. Methods We studied United Kingdom–resident patients born in Africa to examine DAA effectiveness in LMICs where there is far greater breadth of HCV genotypes/subtypes. Viral genome sequences were determined from 233 patients. Results Full-length viral genomic sequences for 26 known subtypes and 5 previously unidentified isolates covering 5 HCV genotypes were determined. From 149 patients who received DAA …