Digital Commons Network^™

April 20, 2021 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Georgia Southern immunology expert to give presentation, hold Q&A on Coronavirus vaccines for ‘Science on Tap’ series to build vaccine confidence

• Georgia Southern’s Master of Public Administration program to be offered in Savannah Fall 2021

Application Of An Evidence-Based, Out-Patient Treatment Strategy For Covid-19: Multidisciplinary Medical Practice Principles To Prevent Severe Disease☆, Elliot M. Frohman, Nicole R. Villemarette-Pittman, Adriana Rodriguez, Robert Glanzman, Sarah Rugheimer, Oleg Komogortsev, Scott S. Zamvil, Roberto A. Cruz, Thomas C. Varkey, Ashley N. Frohman

School of Medicine Publications

The COVID-19 pandemic has devastated individuals, families, and institutions throughout the world. Despite the breakneck speed of vaccine development, the human population remains at risk of further devastation. The decision to not become vaccinated, the protracted rollout of available vaccine, vaccine failure, mutational forms of the SARS virus, which may exhibit mounting resistance to our molecular strike at only one form of the viral family, and the rapid ability of the virus(es) to hitch a ride on our global transportation systems, means that we are will likely continue to confront an invisible, yet devastating foe. The enemy targets one of …

Characterizing The Inducible 1-Cysteine Peroxiredoxin Promoter In Plasmodium Berghei, Lara Ladney

Undergraduate Research and Engagement Symposium

Malaria is one of the world’s deadliest infectious diseases. The malaria parasite Plasmodium requires two hosts: the human and Anopheles mosquito. My research project seeks to understand the antioxidant defense mechanisms Plasmodium employs to withstand the hostile extracellular environment of the Anopheles mosquito vector through upregulation of 1-Cysteine Peroxiredoxin (1-CPrx). When activated, 1-CPrx counteracts reactive oxygen species released by the mosquito. We hypothesize 1-CPrx promoter activation is driven by an antioxidant response element. My objective is to locate the promoter of 1-CPrx through a “promoter bashing approach” using luciferase reporter constructs transfected into Plasmodium and characterize the ARE.

2021-04-19_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Development Of A Highly Selective Plasmodium Falciparum Proteasome Inhibitor With Anti-Malaria Activity In Humanized Mice., Wenhu Zhan, Hao Zhang, John Ginn, Annie Leung, Yi J. Liu, Mayako Michino, Akinori Toita, Rei Okamoto, Tzu-Tshin Wong, Toshihiro Imaeda, Ryoma Hara, Takafumi Yukawa, Sevil Chelebieva, Patrick K. Tumwebaze, Maria Jose Lafuente-Monasterio, Maria Santos Martinez-Martinez, Jeremie Vendome, Thijs Beuming, Kenjiro Sato, Kazuyoshi Aso, Philip J. Rosenthal, Roland A. Cooper, Peter T Meinke, Carl F. Nathan, Laura A. Kirkman, Gang Lin

Natural Sciences and Mathematics | Faculty Scholarship

Plasmodium falciparum proteasome (Pf20S) inhibitors are active against Plasmodium at multiple stages-erythrocytic, gametocyte, liver, and gamete activation stages-indicating that selective Pf20S inhibitors possess the potential to be therapeutic, prophylactic, and transmission-blocking antimalarials. Starting from a reported compound, we developed a noncovalent, macrocyclic peptide inhibitor of the malarial proteasome with high species selectivity and improved pharmacokinetic properties. The compound demonstrates specific, time-dependent inhibition of the β5 subunit of the Pf20S, kills artemisinin-sensitive and artemisinin-resistant P. falciparum isolates in vitro and reduces parasitemia in humanized, P. falciparum-infected mice.

Animated Videos: The Covid-19 Pandemic, Bailey Alspach

Honors Projects

This project is a resource created to provide information about the Covid-19 pandemic. This pandemic was caused by the SARS-CoV-2 virus (AJMC Staff, 2021). The first reported cases began to appear in December 2019, and the World Health Organization (WHO) declared COVID-19 a pandemic on March 11th, 2020. This pandemic is still active with new cases reported everyday as of April 2021 (AJMC Staff, 2021). This resource consists of four videos ranging from around two and a half to eight minutes long. All videos were created in an animated fashion and were uploaded to YouTube. The first video focuses on …

Preprocedure Covid-19 Testing In Early Phase Of Pandemic, Renuka Jain, Bradley Kruger, Robert Citronberg, Stacie Kroboth, Ana Cristina Perez Moreno, Bijoy K. Khandheria

Journal of Patient-Centered Research and Reviews

The COVID-19 pandemic led to a nationwide shutdown of elective medical procedures. Upon resumption of services, preprocedure nasopharyngeal swab testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was introduced for all patients requiring surgical or other aerosol-generating procedures. We investigated preprocedure COVID-19 testing in one of the largest U.S. health systems. Patients included in this retrospective, observational study were asymptomatic and scheduled for a procedure or surgery. All patients underwent a nasopharyngeal swab test for SARS-CoV-2 performed 24–72 hours prior to a planned procedure. Clinical demographics, type of procedure, test results, and subsequent procedure status were evaluated. Of 38,608 …

Placenta-Expanded Stromal Cell Therapy In A Rodent Model Of Simulated Weightlessness, Amber M. Paul, Linda Rubinstein, Charles Houseman, Metadel Abegaz, Steffy Tabares Ruiz

Publications

Long duration spaceflight poses potential health risks to astronauts during flight and re-adaptation after return to Earth. There is an emerging need for NASA to provide successful and reliable therapeutics for long duration missions when capability for medical intervention will be limited. Clinically relevant, human placenta-derived therapeutic stromal cells (PLX-PAD) are a promising therapeutic alternative. We found that treatment of adult female mice with PLX-PAD near the onset of simulated weightlessness by hindlimb unloading (HU, 30 d) was well-tolerated and partially mitigated decrements caused by HU. Specifically, PLX-PAD treatment rescued HU-induced thymic atrophy, and mitigated HU-induced changes in percentages of …

Seroprevalence Of Sars-Cov-2 Antibody In Echocardiography And Stress Laboratory, Renuka Jain, Stacie Kroboth, Denise Ignatowski, Bijoy K. Khandheria

Journal of Patient-Centered Research and Reviews

Purpose: Transesophageal echocardiography is an aerosol-generating procedure, and exercise stress testing is a potentially aerosol-generating activity. Concern has been raised about heightened risk of transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among health care personnel participating in these procedures. We aimed to investigate the prevalence of past coronavirus disease 2019 (COVID-19) infection in echocardiography and stress laboratory staff.

Methods: All staff who worked in the echocardiography and stress laboratories of one high-traffic urban hospital from March 15, 2020, to June 15, 2020, were asked to voluntarily participate. Those willing to participate were consented, and past COVID-19 infection was …

Reducing Mental Illness Stigma: What Types Of Images Are Most Effective?, Roma Subramanian, Jonathan Santo

Psychology Faculty Publications

Public stigma against mental illness is a barrier to treatment and recovery. Research into the design of anti-stigma messages has focused heavily on text; there is limited information on what types of images are most persuasive in eliciting anti-stigma outcomes. This is important to study because the type of image used to depict an illness can influence how the illness is perceived, which in turn can affect how people with the illness are treated. Through an online experiment with 162 American adults, this study investigated whether mental illness narratives about depression illustrated with photographs are more effective than those illustrated …

Intermittent Fasting: The Solution To Overeating And Food Conservation, Ethan Dekam, James Berg

Celebrating Scholarship and Creativity Day (2018-)

No abstract provided.

Feeding 10 Billion: Cultured Meat As A Sustainable Protein Source For A Growing Population, Elisabeth Dalki, Adelle Desutter

Celebrating Scholarship and Creativity Day (2018-)

No abstract provided.

The Greta Thunberg Effect: Student Nurses’ Attitudes To The Climate Crisis, J Richardson, J Aronsson, D Clarke, J Grose

School of Nursing and Midwifery

The risks of the climate crisis and environmental damage have recently been highlighted in the media – for example, through the actions of climate activist Greta Thunberg. The negative impacts of the climate crisis on health and healthcare are well documented, with reports of unacceptable levels of risk for the health of populations worldwide. We compared the attitudes towards sustainability and the climate crisis of student nurses starting a nursing degree in 2019 with those from 2014. Study results showed that the 2019 students were more likely to agree that the climate crisis and sustainability are important topics in nursing …

Bibliometric Evaluation Of The Scopus Indexed Scholarly Literature Of Ministry Of National Guard – Health Affairs, Saudi Arabia, Ikram Ul Haq, Shafiq Ur Rehman, Hanan Al-Kadri, Abid Iqbal

Library Philosophy and Practice (e-journal)

The research analysis output is one of the leading indicators to assess the quality of clinical care, education, and research in healthcare organizations. This study aims to evaluate the scholarly publication growth of the Saudi Arabian Ministry of National Guard – Health Affairs (MNG-HA), indexed in the Elsevier’s Scopus database since 2002.

The study was performed using different bibliometric and visualization techniques. While the highest number of publications indicate King Saud bin Abdulaziz University for Health Sciences as an affiliated address, however, the publications from King Abdulaziz Medical City have the maximum citation impact. The ‘Saudi Medical Journal’ has been …

2021-04-18_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Pandemic Pirates: An Essay Calling For Legislation Curbing Pandemic Profiteering, Gregory Smith

Lincoln Memorial University Law Review Archive

No abstract provided.

How Are You Measuring Success? A Sociological Lens On Evaluating Recovery Courts And The Opioid Misuse Crisis In Appalachia, Aubrey Maples

Lincoln Memorial University Law Review Archive

No abstract provided.

The Investigation Of Appalachian Public Health, Patricia A. Clem

Honors Theses

Public health in Appalachia is a complex area of study. While urban-rural disparities have been a focus of researchers and policy-makers for decades, inequalities continue to grow. During the past two semesters of Honors Thesis Research, the prevalence of disparities between Appalachian college students and non-Appalachian college students at Eastern Kentucky University was brought into question. Through the use of outside sources and surveys amongst current EKU students, this research was conducted to discover not only the challenges that Appalachian college students face, but also what this campus can do to help acknowledge and mitigate the students’ challenges; therefore, increasing …

Correlation Of Severity Of Covid-19 Disease With Gastrointestinal Manifestations And Liver Injury - A North Brooklyn Community Hospital Experience: A Retrospective Cohort Study, Kitson Deane, Ajay Singh, Azza Sarfraz, Zouina Sarfraz, Lyam Ciccone, Beishi Zheng, Arslan Afzal, Gulam Khan, Giovanna Rodriguez, Gul Bahtiyar

Department of Paediatrics and Child Health

Introduction: The primary receptor for SARS-CoV-2 infection, angiotensin-converting enzyme-2 (ACE-2), is expressed in the gastrointestinal tract and liver parenchyma. The involvement of the gastrointestinal tract with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has remained unclear. The following study retrospectively reviews gastrointestinal symptoms and liver function tests at the time of hospital admission to identify patient outcomes including prolonged hospital stay, the requirement for intensive care, and all-cause in-hospital 30-day mortality.
Methods: A retrospective review of patient charts at the Woodhull Medical and Mental Health Center (WMC) was conducted at the time of hospital admission, using a pre-determined selection criterion. …

Implementing The Quality Of Care Partnership To Reduce The Cost Of Screenings For Sexually Transmitted Infections On A Southeastern College Campus, Amy Guidera

DNP Projects

College students are a priority preventative healthcare population that can engage in high risk behaviors which may concurrently increase the potential for unsafe sexual practices, including contracting sexually transmitted infections (STIs). Early education, screening, treatment, and partner notification are important interventions for breaking the chain of transmission and recurrence in relation to preventing poor health outcomes and mitigating college dropout rates. The aim of this quality improvement project was to determine if the reduction in STI screening costs for college students (aged 18-30 years old) would increase the amount of STI screenings conducted at a university health center over the …

Pandemic Emotions: The Good, The Bad, And The Unconscious —Implications For Public Health, Financial Economics, Law, And Leadership, Peter H. Huang

Northwestern Journal of Law & Social Policy

Pandemics lead to emotions that can be good, bad, and unconscious. This Article offers an interdisciplinary analysis of how emotions during pandemics affect people’s responses to pandemics, public health, financial economics, law, and leadership. Pandemics are heart-breaking health crises. Crises produce emotions that impact decision-making. This Article analyzes how fear and anger over COVID-19 fueled anti-Asian and anti-Asian American hatred and racism. COVID-19 caused massive tragic economic, emotional, mental, physical, and psychological suffering. These difficulties are interconnected and lead to vicious cycles. Fear distorts people’s decision readiness, deliberation, information acquisition, risk perception, and thinking. Distortions affect people’s financial, health, and …

Designing Dape- Inhibitors Through Molecular Dynamic Simulations, Kristeen Bebla

Undergraduate Research and Engagement Symposium

Development of new classifications of inhibitors are essential in order to control infectious diseases. Currently the only antibiotics available follow two approaches: inhibition of cell wall remodeling and protein synthesis. DapE is part of the succinylase biosynthetic pathway and is important to the production of lysine and mDap (meso-diaminopimelate) both of which synthesize protein and bacterial peptidoglycan cell wall remodeling. Due to increasing bacterial resistance, a new method of treatment is critical through inhibition of the enzymatic activity of DapE. There is no evidence of DapE in mammals, therefore, inhibition should be selective in thwarting bacterial growth. High-Throughput Screening (HiTS) …

Wellness Through Answers News V36:No.1 January-February 2021, Wendy Urciuoli

Articles - Patient Care

No abstract provided.

2014 Health Demographics Of A Rural Nicaraguan Community, Andrew Guymon, Brianna Mcgowen, Emma Foster

Research Symposium

In December 2014, a team of church members and associated healthcare workers from Owasso First Assembly in Owasso, Oklahoma, provided a free, two-day clinic and health assessment to the rural community of La Ceiba Dudu in Nicaragua. Services included medical exams, basic medications, dental extractions, and over the counter reading glasses. This report is a retrospective review of the patient records documented at that clinic. We analyzed the prevalence of parasites across five age cohorts and searched for correlations between parasite diagnosis and various patient metrics, including BMI, age, and gender. We searched for a relationship between occupants per household …

2021-04-16_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Pandemic, Politics, Public Health , And The Fda, Jordan Paradise, Becky Bavlsik

Belmont Law Review

No abstract provided.

The Gut-Brain Axis And The Apparent Links To Autism Spectrum Disorders, Macgregor Thomas

Research Symposium

In recent years, researchers have pushed the boundaries of understanding of the human microbiome. Studies have pointed towards the involvement of gut bacteria in human health for decades, but now scientists have begun to acquire a more comprehensive understanding of the symbiotic relationship that bacteria have with their hosts. Research shows that gut bacteria can influence an organism's neural and immune system development, behavior, mood, and even neurotransmitter concentrations. Like other systems in the human body, a delicate balance of homeostasis, acting through bidirectional communication between the central nervous system and the gut, keeps this system in check. Studies show …

Orally Delivered Mk-4482 Inhibits Sars-Cov-2 Replication In The Syrian Hamster Model, K Rosenke, Frederick Hansen, Benjamin Schwarz, F Feldmann, Elaine Haddock, R Rosenke, Kent Barbian, Kimberly Meade-White, Atsushi Okumura, Shanna Leventhal, David W. Hawman, Emily Ricotta, Catharine M. Bosio, Craig Martens, Greg Saturday, H Feldmann, Michael A. Jarvis

School of Biomedical Sciences

AbstractThe COVID-19 pandemic progresses unabated in many regions of the world. An effective antiviral against SARS-CoV-2 that could be administered orally for use following high-risk exposure would be of substantial benefit in controlling the COVID-19 pandemic. Herein, we show that MK-4482, an orally administered nucleoside analog, inhibits SARS-CoV-2 replication in the Syrian hamster model. The inhibitory effect of MK-4482 on SARS-CoV-2 replication is observed in animals when the drug is administered either beginning 12 h before or 12 h following infection in a high-risk exposure model. These data support the potential utility of MK-4482 to control SARS-CoV-2 infection in humans …

Adolescent Undernutrition In South Asia: A Scoping Review, Sara Estecha Querol, Paramjit Gill, Romaina Iqbal, Maartje Kletter, Neslihan Ozdemir, Lena Al-Khudairy

Community Health Sciences

Undernutrition is a growing public health challenge affecting growth and development during adolescence in many low- and middle-income countries. This scoping review maps the evidence on adolescent undernutrition (stunting, thinness and micronutrient deficiencies) in South Asia and highlights gaps in knowledge. Using Arksey and O'Malley's framework and the Joanna Briggs Institute Reviewers' Manual, the search included electronic bibliographic databases (Medline (OVID), Embase, Cochrane Library, Web of Science, CINAHL, PsycInfo, and Scopus) as well as various grey literature sources published up to March 2019. In total, 131 publications met the inclusion criteria of this review. All the included evidence used quantitative …