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Covid-19: An Optimal Strategy To Resume Life With Safety And Economic Prosperity, Skyler Tate

Finance Undergraduate Honors Theses

The coronavirus pandemic has hit the world hard since the beginning of 2020, and the United States has certainly felt a negative impact. Many important aspects of life have been greatly altered by the pandemic, and this has resulted in a hindered economy. The purpose of this project was to determine if there is an optimal strategy with respect to policy and the economy that the United States could implement in order to mitigate the coronavirus. In order to determine this, I evaluated multiple aspects of the disease through a literature review. Upon review, I conducted a survey and performed …

Development Of Nucleic Acid Aptamers To Inhibit Bacterial Efflux Pumps, Emilie A. Moses

Honors Theses

Multidrug resistance in bacteria, defined as the ability of a bacterial strain to resist the killing effects of more than one antibiotic, represents a major threat to global healthcare. Every year in the United States, two million people are infected with a multidrug resistant strain of bacteria. According to the Center for Disease Control (CDC), out of those two million people, about 35,000 will die from their infection. Thus, these multidrug resistant diseases are considered by the CDC to be the most dangerous diseases in the world. While multidrug resistance can occur through several different mechanisms, a major contributor to …

Cardiovascular Mechanisms In Covid-19: Methodology Of A Prospective Observational Multimodality Imaging Study (Cosmic-19 Study), Shirjel Alam, Anoop Shah, Kevin Onyinkwa, Edward Nganga, Samuel Gitau, Khalid Makhdomi, Michael Chung, Sudhir Vinayak

Imaging & Diagnostic Radiology, East Africa

Background: 8-28% of patients infected with COVID-19 have evidence of cardiac injury, and this is associated with an adverse prognosis. The cardiovascular mechanisms of injury are poorly understood and speculative. We aim to use multimodality cardiac imaging including cardiac magnetic resonance (CMR) imaging, computed tomography coronary angiography (CTCA) and positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro- D-glucose integrated with computed tomography (18F-FDG-PET/CT) to identify the cardiac pathophysiological mechanisms related to COVID-19 infections.

Methods: This is a single-centre exploratory observational study aiming to recruit 50 patients with COVID-19 infection who will undergo cardiac biomarker sampling. Of these, 30 patients will undergo …

The Effects Of Covid-19 On Healthcare Workers: An Exploration Of Burnout, Cherise Fernandez

Nursing | Senior Theses

The healthcare workplace has been challenged with the SARS-CoV-2 corona virus (COVID-19) for majority of the year 2020 and it has posed a number of challenges for healthcare workers (HCWs). Due to the increased workload and demanding work hours, the prevalence of physician burnout has increased amongst this population. The escalation of burnout may lead to negative effects on physical and mental health. This poses a health concern amongst patients because the increase of burnout affects patient care, safety, and quality of care. Various surveys have been sent out to HCWs in order to determine if burnout has increased within …

Component Causes Of Infectious Bovine Keratoconjunctivitis - The Role Of Moraxella Species In The Epidemiology Of Infectious Bovine Keratoconjunctivitis, John Dustin Loy, Matthew Hille, Gabriele Maier, Michael L. Clawson

School of Veterinary and Biomedical Sciences: Faculty Publications

Moraxella bovis can cause infectious bovine keratoconjunctivitis (IBK).

The role of M bovoculi in IBK is not fully understood.

M bovis and M bovoculi appear to undergo genetic recombination with each other or other members of the Moraxellaceae.

Recombination complicates their classification and potential role(s) in IBK pathogenesis.

MALDI-TOF MS is used to identify M bovis, 2 major strains or genotypes of M bovoculi, M ovis, and other members of the Moraxellaceae.

Classification and determination of pathogenesis potential within Moraxella species may be better understood through whole genome sequencing.

Examining The Effects Of Exogenous Polyunsaturated Fatty Acids On The Antimicrobial Activity Of Piscidins In Vibrio Cholerae, Elizabeth Allen

Honors Theses

Antimicrobial peptides are found in all organisms and have gained notoriety in recent years for their effectiveness against a variety of pathogens. Piscidins, first isolated from the mast cells of vertebrates, comprise a family of these host defense peptides. Piscidins 1 (P1) and 3 (P3), found in sea bass and other fishes, are isoforms with different modes of action. P1 induces membrane perturbation, while P3 binds DNA to exert antibacterial activity. Each has the ability to bind Cu2+ (P1Cu and P3Cu) which dramatically impacts their antimicrobial characteristics. The purpose of this study was to investigate the activity of metallated and …

Molecular Interactions Of Human Cell Proteins With Sars-Cov-2 Versus Influenza Viruses, Linze Cowman

Honors Thesis

Molecular Interactions of Human Cell Proteins with SARS-CoV-2 versus Influenza

Viruses

Linze Cowman

Director: Victor Huber, Ph.D.

The novel Coronavirus Disease 2019, or COVID- 19, shows considerable similarity to a common influenza infection. Over the past year, innumerable studies have been investigating the Vitus in various capacities, from big-picture public health repercussions to the virus' biochemical interactions with human cells for infection. This research provides invaluable information in the ongoing war against infectious diseases. While the influenza virus is fairly well-understood, much surrounding the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains unclear, including its longevity, long-term health effects, methods …

Organizational Rights In Times Of Crisis, Adam Chilton, Mila Versteeg

University of Chicago Law Review

As populist leaders gain power around the world, democratic governments retreat, and authoritarian states gain power in the international system,¹ it is critical to find levers of resistance. Professors Adam Chilton and Mila Versteeg’s masterful volume, How Constitutional Rights Matter, offers a timely and provocative answer: let’s look to organizations as potential defenders of rights in challenging times.² In a world in which human rights are widely understood as individual rights, it is high time to theorize about how organizations can help vindicate these individual protections.

The specific thesis Chilton and Versteeg promote is that “some rights, once …

Physicians' Elusive Public Health Duties, Richard S. Saver

North Carolina Law Review

No abstract provided.

A Survey Of Mosquito-Borne And Insect-Specific Viruses In Hospitals And Livestock Markets In Western Kenya, Tatenda Chiuya, Daniel K. Masiga, Laura C. Falzon, Armanda D.S. Bastos, Eric M. Fèvre, Jandouwe Villinger

All Peer-Reviewed Publications

Aedes aegypti and Culex pipiens complex mosquitoes are prolific vectors of arboviruses that are a global threat to human and animal health. Increased globalization and ease of travel have facilitated the worldwide dissemination of these mosquitoes and the viruses they transmit. To assess disease risk, we determined the frequency of arboviruses in western Kenyan counties bordering an area of high arboviral activity. In addition to pathogenic viruses, insect-specific flaviviruses (ISFs), some of which are thought to impair the transmission of specific pathogenic arboviruses, were also evaluated. We trapped mosquitoes in the short and long rainy seasons in 2018 and 2019 …

Parenting, Vaccines, And Covid-19: A Machine-Learning Approach, Kathleen Thurson

All Theses

COVID-19 is currently at the forefront of both out-of-school time program providers’ and parents’ minds, with additional policies and procedures added existing operating standards to protect the health of participants, staff, and parents (Environmental Health & Engineering, 2020). A failure to adequately prepare and react to different parenting styles may have both operational and financial implications for out-of-school time programs. These implications are only further exacerbated in the additional context of a global pandemic. While the COVID-19 vaccine is a hope to many that the end of the pandemic is near, parental vaccine hesitancy or refusal may pose a significant …

Genome-Wide Association Studies Of Antimicrobial Activity In Global Sorghum [Sorghum Bicolor (L.) Moench], Lindsay Kaye Shields

All Theses

Sorghum is a common feed grain globally with vast genetic and phytochemical diversity that may provide numerous health benefits, including its aptitude as an antimicrobial feed grain. This study highlights the antimicrobial potential of a collection of 384 diverse sorghum accessions against two prominent foodborne pathogens, Clostridium perfringens and Salmonella enterica. Following extensive screening, we determined that sorghum grain extract is more efficient at inhibiting C. perfringens than S. enterica. Antimicrobial activity observed against C. perfringens was not significantly correlated with either total phenols (r = 0.12) or tannin concentration (r = 0.12). Moreover, we mapped loci associated …

Virtual Autopsies—The New Kid On The Block In Death Investigations, Samuel D. Hodge Jr., Lauren Williams

University of Dayton Law Review

No abstract provided.

Prevalence Of Mycoplasma Genitalium And Macrolide Resistance In Adolescent Females Receiving Care At A Pediatric Hospital, Kayla Barnes, Bishnu Adhikari, Rangaraj Selvarangan, Christopher J. Harrison, Melissa K. Miller

Posters

Background: Mycoplasma genitalium is an established sexually transmitted cause of nongonococcal urethritis in males and macrolide resistance is increasing. The pathogenic role is less well-defined in adolescent females and guidelines recommend M. genitalium testing only be considered in cases of persistent or recurrent cervicitis and pelvic inflammatory disease (PID). We lack understanding of the prevalence and macrolide resistance of M. genitalium in adolescent females.


Objective: To determine the prevalence of M. genitalium and rate of detected macrolide resistance among adolescent females seeking care at a pediatric children’s hospital.


Design/Methods: We collected 200 salvaged urogenital samples (56 urine and 144 vaginal) …

From Starter To Finish: Learning The Literacy Of Sourdough, Molly Mcconnell

Department of English: Dissertations, Theses, and Student Research

Using the New Literacy Studies and the work of James Paul Gee, the process of making sourdough bread is conceptualized as a literacy, which is then located within food literacy. The literacy of sourdough offers an alternative to neoliberal discourse. The literacy is linked to the rise in popularity of sourdough during the COVID-19 pandemic and is used to explore Bourdieu’s cultural capital. It also connects, rhizomatically (Deleuze and Guattari), and is used to explore concepts of interdependence and time. After establishing this literacy, a pedagogically- focused essay draws upon ecocomposition to expand on what a composition process would look …

Genome Evolution And Population Dynamics Of Staphylococcus Bacteria, Joshua Smith

Doctoral Dissertations

The gram-positive bacterial genus Staphylococcus (phylum Firmicutes) is a heterogeneous group that consists of commensals and opportunistic pathogens of humans and animals. To date, there are 57 validly published species according to the List of Prokaryotic names with Standing in Nomenclature (LPSN). The most well-studied and widely sampled species is Staphylococcus aureus, which causes a wide range of diseases in humans from relatively minor skin infections to much more invasive and serious sepsis, pneumonia, or endocarditis. For many years, Staphylococcus other than S. aureus have been regarded as non-pathogenic, but these bacteria are now being recognized as potential pathogens in …

Mapping The Domain Of Rna Helicase Ddx1 That Interacts With The Ns1 Of Influenza A Viruses, Elise Wyatt

Biomedical Engineering Undergraduate Honors Theses

Of the known influenza virus strains, influenza A viruses (IAVs) are the most catastrophic due to their highly contagious nature and possibly life-threatening symptoms. IAVs invade a host cell and enter the nucleus where they use the cell’s nuclear machinery for replication of their viral RNA genome which is then exported to neighboring cells to establish a productive infection. Host pathogen recognition receptors (PRRs) respond to viral infection by signaling the cell to produce type I interferons (IFNs) to fight the foreign invader. Non-structural protein 1 (NS1) of IAVs, a major component in the regulation of viral replication, opposes host …

Theoretical Assessment Of Plant Alkaloids For Potential Toxicity And Environmental Impacts, Xiara Day

Theses (2016-Present)

Alkaloids are secondary plant metabolites that serve as a defense mechanism against herbivores and other predators. There are over 12,000 alkaloids known. Plant alkaloids exhibit a great cause for concern as they are often found in various food sources such as wheats, cereals, spices, herbs, and honey. The toxicity of plant alkaloids poses as a significant danger to both wildlife and humans. Genotoxicity, carcinogenicity, pneumotoxicity and, more notably, hepatotoxicity are all associated with the chronic consumption of plant alkaloids. It is believed that the physical and chemical properties of plant alkaloids attribute to their toxicity. The objective of this study …

Effects Of The Covid-19 Pandemic On The Health Of American Indians, Heather Bates

Physician Assistant Scholarly Project Papers

COVID-19 has been most devastating to the elderly and those living in dense communities, which disproportionately affects American Indians as they are medically underserved. American Indians tend to live in multigenerational housing which puts them at higher risk for transmission of COVID-19. To determine other risk factors and the long-term physical and mental health impacts of COVID-19 on American Indians, a literature review was completed using metaanalyses and case studies. The results of this study confirm that age is the most substantial risk factor for severe COVID-19 illness, complication, and mortality, regardless of race or ethnicity. However, American Indians are …

Covid-19 Impact On Lifestyle And Psychosocial Issues, Ayana M. Smith, Bessie Josephine Hernandez

Electronic Theses, Projects, and Dissertations

COVID-19 is a pandemic that hit the United States recently in early 2020 affecting individuals with regards to behavior, healthcare, education, recreation and social interaction, and employment and economic impact. The purpose of this study was to survey San Bernardino residents to identify, describe, and evaluate the impact of Coronavirus (COVID-19) on their lives to understand their needs and to plan for future pandemics. This exploratory study used a qualitative method to collect data from 12 respondents in video interviews. A major finding was that, regarding behavior, most if not all participants had behavior changes to comply with Centers for …

The Need For Financial Literacy In Social Work Education: A Descriptive Study, Tara Mchenry, Belinda Pacheco

Electronic Theses, Projects, and Dissertations

Although extensively researched over the last twenty years, financial literacy is yet to make its way into mainstream social work curricula. This is puzzling because social workers, in general, work with a clientele that consists predominantly of poor and low-income populations. The profession of social work has the unique opportunity to equip its members with tools to educate and assist clients around topics of personal finance and financial insecurity. Using a purposive sampling method, this study explored the need for a financial literacy course as part of the social work curriculum among 102 undergraduate and graduate students in a large, …

How The Covid-19 Pandemic Has Affected Physical Activity, Sleep And Mental Health In University Students, Faculty And Staff And To Examine The Relationship Between These Variables, Zachary Parisi

Health, Human Performance and Recreation Undergraduate Honors Theses

Background: Increased physical activity has been shown to be beneficial in decreasing stress. This project will expand on this knowledge while also studying college students, a demographic that has been less studied. This study will also examine the impact of COVID-19 on these variables. COVID-19 changed many peoples’ activities of daily life, and possibly physically activity levels, due to public health measures such as lockdowns and remote learning. Purpose: The purpose of this study is to examine how the COVID-19 pandemic has affected physical activity, sleep, and mental health in university students, faculty and staff and to examine the relationship …

Recent Advances In Understanding Tick And Rickettsiae Interactions, Shahid Karim, Deepak Kumar, Khemraj Budachetri

Faculty Publications

Ticks are haematophagous arthropods with unique molecular mechanisms for digesting host blood meal while acting as vectors for various pathogens of public health significance. The tick's pharmacologically active saliva plays a fundamental role in modulating the host's immune system for several days to weeks, depending on the tick species. The vector tick has also developed sophisticated molecular mechanisms to serve as a competent vector for pathogens, including the spotted fever group (SFG) rickettsiae. Evidence is still inadequate concerning tick–rickettsiae–host interactions and saliva-assisted transmission of the pathogen to the mammalian host. Rickettsia parkeri, of the SFG rickettsia, can cause a …

The 2020 Impact: Rethinking Brand Approach To Sustainability Through A Postcolonial And Environmental Justice Framework, Simone Hassan-Bey

Business/Business Administration

Social unrest as a result of a pandemic and the movement for Black lives created a greater demand for big brands to increase their involvement in social responsibility. In this work, I examine the relationship between big brands to their colonial and environmental legacies to analyze how they have historically responded to social justice issues and how it has helped or hindered their journey towards sustainability. My research suggests that these brands may be failing to live up to their social responsibility claims because they struggle to see how the two actors are interconnected, as a result, I offer a …

Finding Alternatives To Conventional Antibiotics In Face Of Multidrug Resistance (Mdr) Bacteria Crisis, Benitha Muyizere

Biological Sciences

With a growing concern of healthcare crises like the current COVID-19 pandemic, the healthcare sector is in a dire need of finding solutions to the increasing multidrug resistance in microbial organisms. In the 2019, the UN Ad hoc Interagency Coordinating Group on Antimicrobial Resistance stated that if ignored, multidrug resistance organisms (MDROs) could cost 10 million lives each year by 2050. However, this is not a problem of the “future” per say, it is rather of the past, the present, and the future. According to the World Health Organization (WHO), approximately 700,000 people die of multidrug resistance (MDR) each year. …

Current Challenges In Covid-19 Triaging: A Global Perspective, Mauli Patel, Robin Sudandiradas, Trini Mathew, Paul Kilgore, Mahadev Rao, Chiranjay Mukhopadhay, Marcus Zervos

Conference Presentation Abstracts

Background and Objectives: Although countries around the world have been combatting the same COVID-19 pandemic over the last year, the triage approach taken by various Emergency Departments (ED) is unique. This paper outlines the guidelines followed by two tertiary care hospitals in Detroit, USA and Manipal, India. By comparing hospital triage implementation protocols, this paper offers insight regarding similarities and differences between Detroit and Manipal ED, as well as strategies to overcome respective challenges. Methods: Triage algorithms from the Detroit Medical Centre in Detroit and Kasturba Medical College Hospital in Manipal were contrasted to illustrate the similarities and differences in …

Comparison Of Mortality Data From Nebraska’S Rural & Metropolitan Health Districts, Claire Figi

Theses/Capstones/Creative Projects

As there has been minimal research done on the correlation between communities identified as rural or metropolitan and their mortality rates, this research aims to provide baseline evidence that mortality rates associated with non-infectious and infectious diseases are connected to an area’s rural or metropolitan classification. This study analyzed public data from the Nebraska Department of Health and Human Services and the Center for Disease Control to compare mortality rates related to the top two causes of death in both rural and metropolitan health districts of the state of Nebraska, United States. This data was then compared to mortality rates …

Determine The Effects Of Propionate On The Activation Of Macrophages Against The Intracellular Pathogen Listeria Monocytogenes, Leah O. Allen

Honors Theses

The main goal of this research is to see how propionate, a common food preservative and an important metabolite in humans, alters the activation of our immune system. The effects of propionate on macrophage activation will be determined by using nitrite and LDH assays. For these assays, different concentrations of propionate will be tested to determine how macrophages respond to the activation by LPS and interferon gamma. Another goal of this project is to determine the effects of propionate and macrophage activation on intracellular survival of L. monocytogenes. A gentamicin protection assay will be used to better establish the role …

Determine The Effects Of Propionate On The Interactions Between Macrophages And Listeria Monocytogenes, Stephanie M. Johnson

Honors Theses

Listeria monocytogenes is an opportunistic and intracellular foodborne pathogen that can be deadly in high risk populations. During infection in the human body, L. monocytogenes may encounter macrophages, a type of white blood cell that is critical in innate immune response both by directly targeting invading pathogens and by eliciting adaptive immune responses. During intestinal as well as peripheral infections, both L. monocytogenes and macrophages may encounter propionate, a common gut microbiome metabolite. Although propionate is shown to have various regulatory and nutritional functions, its effects on infection outcome is not well understood. Therefore, the goal of this research is …

A Look At The Anti-Vaccine Movement And Its Impact On Covid-19, Kathryn Ann Famiglietti

Senior Honors Projects

No abstract provided.