Digital Commons Network^™

Efficacy Of Live Attenuated Dengue Vaccines: Cyd-Tdv, Tdv (Tak-003), And Tv003/Tv005, Yoseph Jeffry Hertanto, Bernadette Dian Novita

Folia Medica Indonesiana

Highlight: • Differences in the efficacy of CYD-TDV versus the other TAK-003 and TV003/TV005 were discussed. • One licensed dengue vaccine is CYD-TDV (Dengvaxia). Abstract: Dengue fever is the most common tropical disease, but there still remains no specific therapy that can overcome it. Special attention needs to be paid to this disease, because there were large increases in incidence in the last decade. As an effective preventive strategy, finding a new vaccine for dengue fever with higher potentiation and efficacy is highly necessary to stop dengue transmission especially in the endemic area. Vaccine triggers an immune response, so that …

Combining Community Wastewater Genomic Surveillance With State Clinical Surveillance: A Framework For Sars-Cov-2 Public Health Practice., Ted Smith, Rochelle H. Holm, Ray Yeager, Joseph B. Moore Iv, Eric C. Rouchka, Kevin J. Sokoloski, Daymond Talley, Vaneet Arora, Sarah Moyer, Aruni Bhatnagar

Faculty and Staff Scholarship

Study objective: To garner a framework for combining community wastewater surveillance with state clinical surveillance that influence confirmation of SARS-CoV-2 variants within the community, and recommend how the flow of such research evidence could be expanded and employed for public health response. Design, setting, and participants: This work involved analyzing wastewater samples collected weekly from 17 geographically resolved locations in Louisville/Jefferson County, Kentucky from February 10 to November 29, 2021. Genomic surveillance and RT-qPCR platforms were used as screening to identify SARS-CoV-2 in wastewater, and state clinical surveillance was used for confirmation. Main results: The results demonstrate increased epidemiological value …

Experiences Of African American Women Living With Herpes Simplex Virus 2, Cherlisa Jackson, Yitza A. Arcelay-Rojas

Journal of Social, Behavioral, and Health Sciences

In the United States, the prevalence of herpes simplex virus 2 (HSV-2) continues to be the highest among African American women. Yet the perceived benefit of discussing sexual health, as well as recognizing a need to discuss HSV-2 with a health-care provider, is a gap in research. The purpose of this interpretive qualitative study was to understand the experiences of African American women who received an asymptomatic HSV-2 diagnosis. Semistructured interviews of seven participants were used to explore the experiences of African American women diagnosed with HSV-2, including barriers and challenges of discussing HSV-2 with health-care providers. Participants highlighted that …

Torment Of Pestilence: Yellow Fever Epidemics In Pensacola, George F. Pearce

Florida Historical Quarterly

For more than a century, yellow fever epidemics intermittently swept over Pensacola, Florida, producing a high mortality, disrupting its economic and social life, dividing community leaders and medical authorities over courses of action in combatting them, causing untold numbers to flee, some permanently, and keeping those who remained in a state of demoralizing terror. The approach of summer each year invariably brought with it the fear of a repetition of the dreadful experience. This atmosphere of apprehension and utter helplessness was nourished by ignorance about the origin, transmission, and prevention of the disease. It was not until 1900 that medical …

Editorial Board

Karbala International Journal of Modern Science

No abstract provided.

The Challenges, Risks, And Concerns Perceived By Iraqi Medical Doctors: A Cross Sectional Study: The Challenges, Risks, And Concerns Perceived By Iraqi Medical Doctors: A Cross Sectional Study, Alaa Abed, Basim Abdul-Hassan, Dhurgham Abdulwahid

Iraqi National Journal of Medicine

Background: The current situation of the health system in Iraq, under the difficult conditions the country has been experiencing, generates great pressures on doctors because they are in the field of confrontation between the growing needs of patients day after day and the dilapidated capabilities and government neglect of the health sector with the absence of security and stability and weak law enforcement.The imposition of state authority has led to an increase in violence in the country in general and against doctors in particular. Moreover, there are other pressures that doctors are subjected to, such as security, economic, professional, social, …

Acceptance Of Covid-19 Vaccine Among General Population In Iraq: Acceptance Of Covid-19 Vaccine Among General Population In Iraq, Hasanain Ghazi, Taqi Taher, Shaymaa Alfadhul, Sumayah Al-Mahmood, Shaimaa Hassan

Iraqi National Journal of Medicine

COVID19 emerged as one of the biggest global public health crises in recent history. Many pharmaceutical companies have raced against time to develop a vaccine, so that the pandemic can be brought under control.  The aim of the current study was to assess the acceptance of the COVID19 vaccine among the general population in Iraq. A cross-sectional study was conducted among 1069 respondents from different states of Iraq using questionnaires administered online. Though a total of 77.6% of the respondents agreed to take the COVID19 vaccine when available, a majority (64.3%) said they would wait for some time before taking …

Hospital Effluents And Wastewaters Treatment Plants: A Source Of Oxytetracycline And Antimicrobial-Resistant Bacteria In Seafood, Bozena Mccarthy, Samuel Obeng Apori, Michelle Giltrap, Abhijnan Bhat, James Curtin, Furong Tian

Articles

The present study employs a data review on the presence and aggregation of oxytetracycline (OTC) and resistance (AMR) bacteria in wastewater treatment plants (WWTPs), and distribution of the contaminated effluent with the aid of shallow and deep ocean currents. The study aims to determine the fate of OTC, AMR bacteria in seafood, and demonstrate a relationship between AMR levels and human health. This review includes (1) OTC, (2) AMR bacteria, (3) heavy metals in aquatic environments, and their relationship. Few publications describe OCT in surface waters. Although, OTC and other tetracyclines were found in 10 countries in relatively low concentrations, …

Electronically Available Patient Claims Data Improve Models For Comparing Antibiotic Use Across Hospitals: Results From 576 Us Facilities, Katherine E Goodman, Lisa Pineles, Laurence S Magder, Deverick J Anderson, Elizabeth Dodds Ashley, Ronald E Polk, Hude Quan, William E Trick, Keith F Woeltje, Surbhi Leekha, Sara E Cosgrove, Anthony D Harris

2020-Current year OA Pubs

BACKGROUND: The Centers for Disease Control and Prevention (CDC) uses standardized antimicrobial administration ratios (SAARs)-that is, observed-to-predicted ratios-to compare antibiotic use across facilities. CDC models adjust for facility characteristics when predicting antibiotic use but do not include patient diagnoses and comorbidities that may also affect utilization. This study aimed to identify comorbidities causally related to appropriate antibiotic use and to compare models that include these comorbidities and other patient-level claims variables to a facility model for risk-adjusting inpatient antibiotic utilization.

METHODS: The study included adults discharged from Premier Database hospitals in 2016-2017. For each admission, we extracted facility, claims, and …

Overexpression Screen Of Interferon-Stimulated Genes Identifies Rarres3 As A Restrictor Of Toxoplasma Gondii Infection, Nicholas Rinkenberger, Michael E Abrams, Sumit K Matta, John W Schoggins, Neal M Alto, L David Sibley

2020-Current year OA Pubs

No abstract provided.

Experiences Of Women Seeking Care For Abortion Complications In Health Facilities: Secondary Analysis Of The Who Multi-Country Survey On Abortion In 11 African Countries., Philip Govule, Sasha Baumann, Jean-Paul Dossou, Clara Calvert, Sourou Goufodji, Hedieh Mehrtash, Özge Tuncalp, Kwame Adu-Bonsaffoh, Rachidatou Compaore, Véronique Filippi

Global Health Faculty Publications

OBJECTIVE: Despite evidence of acute and long-term consequences of suboptimal experiences of care, standardized measurements across countries remain limited, particularly for postabortion care. We aimed to determine the proportion of women reporting negative experiences of care for abortion complications, identify risk factors, and assess the potential association with complication severity.

METHODS: Data were sourced from the WHO Multi-Country Survey on Abortion for women who received facility-based care for abortion complications in 11 African countries. We measured women's experiences of care with eight questions from an audio computer-assisted self-interview related to respect, communication, and support. Multivariable generalized estimating equations were used …

Exploring The Effectiveness Of Robotic Exoskeletons In The Acute Care Phase Of Acquired Brain Injury Rehabilitation, Renee E. Brooks

Department of Occupational Therapy Entry-Level Capstone Projects

No abstract provided.

Connecting Communities During Crisis: A Case Study Of Nonprofit Agencies, People With Disabilities And Access To Covid-19 Vaccines, Brittany R.. Blomquist

Honors Capstones

Individuals with disabilities often face unique challenges not experienced by the general population. These circumstances are further exacerbated in rural communities where health care equity is disrupted by a lack of access to transportation resources to health care providers and economic hardships. The COVID-19 pandemic further amplified these inequities, creating new barriers in rural regions, to health access and health information, by demanding virtual access in place of physical access, requiring individuals to own, afford, and knowledgeably operate technology. This case study explores methodologies employed by three nonprofit Centers for Independent Living (CIL) agencies assisting people with disabilities, in rural …

Extracellular Vimentin As A Target Against Sars-Cov-2 Host Cell Invasion, Łukasz Suprewicz, Maxx Swoger, Sarthak Gupta, Ewelina Piktel, Fitzroy J. Byfield, Daniel V. Iwamoto, Danielle Germann, Joanna Reszeć, Natalia Marcińczyk, Robert J. Carroll, Paul A. Janmey, J. M. Schwarz, Robert Bucki, Alison E. Patteson

Physics - All Scholarship

Infection of human cells by pathogens, including SARS-CoV-2, typically proceeds by cell surface binding to a crucial receptor. The primary receptor for SARS-CoV-2 is the angiotensin-converting enzyme 2 (ACE2), yet new studies reveal the importance of additional extracellular co-receptors that mediate binding and host cell invasion by SARS-CoV-2. Vimentin is an intermediate filament protein that is increasingly recognized as being present on the extracellular surface of a subset of cell types, where it can bind to and facilitate pathogens’ cellular uptake. Biophysical and cell infection studies are done to determine whether vimentin might bind SARS-CoV-2 and facilitate its uptake. Dynamic …

Hiv/Aids After The Crisis: The Evolution Of An Epidemic, Emma Paras

Honors Projects

HIV and AIDS has affected the world for over four decades. In the past, a positive HIV diagnosis could very well be a death sentence, as well as signal that an individual was a social outcast. In the past ten years, however, treatments for HIV/AIDS allow a person to live a long and relatively healthy life. In addition to examining current and future trends in HIV treatment, this paper will also discuss how the virus affects different regions of the world. Particularly in certain parts of Africa, HIV/AIDS remains deadly for many who don’t have proper access to health care …

Standardizing Surgical Skin Antisepsis, Crystal Vackar

MSN Capstone Projects

Skin antisepsis is one of the most critical factors for preventing postoperative surgical site infections, but with the lack of high-quality research, the choice of which preoperative skin antiseptic is best remains a puzzling problem for clinicians (Chen, Chen, Guo, & Xu, 2020). Minimizing the patient’s risk of a surgical site infection by removing skin contaminants at the surgical site is the goal of surgical skin antisepsis. Therefore, the hospital or organization must choose the right product that is cutting costs, is the most effective, saving surgical time, and has the safest results for the patient. Before prepping the skin, …

Ventilator-Associated Pneumonia Bundle Care, Jeemole Kattezham Binnichan

MSN Capstone Projects

Ventilator-associated pneumonia (VAP) is one of the most significant nosocomial infections in intensive care units (ICU) worldwide. Patients who have this infection due to lengthy hospital stays face excessive hospital expenditures and are forced to spend more time away from their families than is necessary. VAP is a prominent cause of morbidity and mortality in ICUs, prompting plenty of studies. The most crucial target is its prevention. Understanding how to reduce VAP would help patients live longer, have a better quality of life, and reduce hospital liability. Ventilator-associated pneumonia bundle (VAPB) has been shown in numerous studies to be an …

A Formal Antibiotic Stewardship Protocol To Reduce Antibiotic Use, Shalese Ladawne Collins

MSN Capstone Projects

Background: Antimicrobial resistance is a nationwide public health crisis which is a result of indiscriminate antibiotic use. Inappropriate antibiotic prescribing for infections have been overlooked for several years in long-term care facilities. The Centers for Disease Control and Prevention have been compelled to require long-term care facilities to start an antibiotic stewardship program that is a key measure to combat antimicrobial resistance and seeks to accomplish this by improving antibiotic use. Many healthcare workers report presumed urinary tract infections to the provider without the accurate understanding of what criteria is required for the need of antibiotics.

Objective: Create a protocol …

Barriers And Facilitators In Rehabilitation In Chronic Diseases And After Surgery: Is It A Matter Of Adherence?, Elijah E. Sanches, Emily Aupers, Nasser Sakran, James Navalta, Tomasz Kostka, Sjaak Pouwels

Kinesiology and Nutrition Sciences Faculty Research

Although it has been generally acknowledged that participating in rehabilitation programs is better for chronic diseases or post-surgery, the adherence rates of these programs remain lower than expected. According to the World Health Organization (WHO), adherence has been defined as follows: "the extent to which a person's behavior corresponds with agreed recommendations from a healthcare provider." In general, rehabilitation is well investigated, and in chronic diseases like chronic obstructive pulmonary disease (COPD), cardiovascular disease, neuromuscular disease, cancer, and even psychiatric diseases like depression, it has been shown that exercise therapy, in particular, has beneficial effects on morbidity, mortality, and convalescence …

Understanding The Effect Of Dietary Palmitic Acid On Glycolysis During Innate Immune Memory In Macrophages, Khaleda A. Aqaei

PSU McNair Scholars Online Journal

Trained immunity is long-term innate immune memory induced by a primary stimulus, which leads to hyper-inflammation upon secondary stimulation with a homologous or heterologous ligand. Trained immunity is mediated by epigenetic and metabolic reprogramming of the target cell and leads to modification of gene expression and cellular function. Classically, trained immunity is initiated by b-glucans, an inflammatory molecule found on the exterior of fungal species. Interestingly, our lab has recently described that dietary fatty acids can initiate trained immunity, working through similar pathways as b-glucans. Specifically, our data show that a pre-treatment with a specific dietary saturated fatty acid (SFA), …

Cellular Agriculture: An Outlook On Smart And Resilient Food Agriculture Manufacturing, Salil Bapat, Vishvesh Koranne, Neha Shakelly, Aihua Huang, Michael Sealy, Kamlakar P. Rajurkar, John W. Sutherland, Ajay P. Malshe

School of Mechanical Engineering Faculty Publications

Over the centuries, the application of grassland and cutting of livestock are the primary foundations for
the production of food agriculture manufacturing. Growing human population, accelerated human
activities globally, staggering food inequity, changing climate, precise nutrition for extended life
expectancy, and more demand for protein food call for a new outlook to smartness in food agriculture
manufacturing for delivering nutritious food. Cellular agriculture, 3D printing of food, vertical urban
farming, and digital agriculture alongside traditional means are envisioned to transform food agriculture
and manufacturing systems for acceptability, availability, accessibility, affordability, and resiliency for meeting demands of food in this century …

2021-12-03_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated three times a week on Mondays, Wednesdays and Fridays.

Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Care) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, …

Covid-19 Investigated In Terms Of Disparities: An Analysis Of The Past, Present, And Future Of Public Health In Illinois, Hannah Deblock

University Honors Program

As a relatively new topic, previous literature fails to address the relation of social determinants of health to COVID-19. By combining existing knowledge on previous epidemics, information on the role of social determinants of health, and data on COVID-19, conclusions can be made about the path going forward. Historically, nonpharmacologic interventions such as quarantine periods, face coverings, and social distancing have been used in epidemics such as the Spanish Influenza of 1918-19. In terms of social determinants of health, geographical location, educational level, and income level all play a part in the health of an individual. Rather than emphasizing personal …

The Molecular Basis For Natural Competence In Acinetobacter, Yafan Yu

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Bacteria use Horizontal Gene Transfer (HGT) to acquire genetic material, leading to the development of novel traits, such as the spread and development of antibiotic resistance. Natural competence is one type of HGT accomplished by DNA uptake from the environment and incorporation into the genome. Bacteria from Acinetobacter are wildly distributed in the environment and are naturally competent. This propensity is a key factor to the steady increase in drug resistance in Acinetobacter, which is a cause for concern in human health as Acinetobacter is a major source of nosocomial infections. During natural competence, type IV pili (T4P) and related …

Usage Statistics: Project Counter R5 Tr_B1 Report Fy2021 - Book Requests (Excluding Oa_Gold) By Title, Andrée Rathemacher

Technical Services Reports and Statistics

Project COUNTER R5 Report TR_B1 for the University of Rhode Island for the period from July 1, 2020 - June 30, 2021. The TR_B1 report is defined as "Book Requests (Excluding OA_Gold)." This report presents an annual total only and only includes those platforms successfully configured for automated harvesting via SUSHI.

File for download is Excel spreadsheet generated by Alma Analytics.

Results:

• Total Item Requests - 84,955
• Unique Title Requests - 38,932

Genomic Epidemiology Of Clostridium Difficile Colonization And Transmission In An Intensive Care Unit Cohort, Brianne Ciferri

Dissertations and Theses

Abstract

Genomic epidemiology of Clostridium difficile colonization and transmission in an intensive care unit cohort

by Brianne Ciferri, MPH

Advisor: C. Mary Schooling, PhD

Introduction: Clostridiodes difficile (C. difficile) is a leading cause of healthcare associated infections (HAI) in the United States and responsible for an estimated incidence of 223,900 cases and 12,800 deaths per year^1,2. C. difficile can cause gastrointestinal illness with symptoms ranging from mild diarrheal illness to a life-threatening condition. C. difficile is an opportunistic pathogen in which spores can live in an undisturbed dormant state within the intestinal tract and become …

Whole-Genome Sequencing-Based Phylogeny, Antibiotic Resistance, And Invasive Phenotype Of Escherichia Coli Strains Colonizing The Cervix Of Women In Preterm Labor., Marvin Williams, Alyssa B. Jones, Amanda L. Maxedon, Jennifer E. Tabakh, Cindy B. Mccloskey, David E. Bard, Daniel P. Heruth, Susana Chavez-Bueno

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Escherichia coli is a major neonatal pathogen and the leading cause of early-onset sepsis in preterm newborns. Maternal E. coli strains are transmitted to the newborn causing invasive neonatal disease. However, there is a lack of data regarding the phenotypic and genotypic characterization of E. coli strains colonizing pregnant women during labor.

METHODS: This prospective study performed at the University of Oklahoma Medical Center (OUHSC) from March 2014 to December 2015, aimed to investigate the colonization rate, and the phylogeny, antibiotic resistance traits, and invasive properties of E. coli strains colonizing the cervix of fifty pregnant women diagnosed with …

Using Nasal Povidone-Iodine To Prevent Bloodstream Infections And Transmission Of Staphylococcus Aureus Among Haemodialysis Patients: A Stepped-Wedge Cluster Randomised Control Trial Protocol, Ana-Monica Racila, Amy O'Shea, Rajeshwari Nair, Kimberly Dukes, Loreen Herwaldt, Linda Boyken, Daniel Diekema, Melissa Ward, Jason Cobb, Jesse Jacob, David Pegues, Susan Bleasdale, Anitha Vijayan, Anubha Mutneja, Mony Fraer, Debra O'Connell-Moore, Pam Tolomeo, Minerva Mendez, Erin Jaworski, Marin Schweizer

Open Access Publications

INTRODUCTION: Approximately 38% of haemodialysis patients carry

METHODS AND ANALYSIS: We will perform an open-label, stepped-wedge cluster randomised trial to assess the effectiveness of nasal PVI compared with standard care. Sixteen outpatient haemodialysis units will participate in the study. The 3-year trial period will be divided into a 4-month baseline period and eight additional 4-month time blocks. The primary outcome of the study will be

ETHICS AND DISSEMINATION: This study has received IRB approval from all study sites. A Data Safety and Monitoring Board will monitor this multicentre clinical trial. We will present our results at international meetings. The study …

Vol.49 N.20 December 2nd 2021, Voice Media Ventures

Black Voice News

No abstract provided.

Covid-19 Modulates Inflammatory And Renal Markers That May Predict Hospital Outcomes Among African American Males, Wendy Fonseca, Nobuhiro Asai, Kazuma Yagi, Carrie-Anne Malinczak, Gina Savickas, Christine C. Johnson, Shannon L. Murray, Edward M. Zoratti, Nicholas W. Lukacs, Jia Li, Charles F. Schuler Iv

Public Health Sciences Articles

BACKGROUND AND OBJECTIVES: African Americans and males have elevated risks of infection, hospitalization, and death from SARS-CoV-2 in comparison with other populations. We report immune responses and renal injury markers in African American male patients hospitalized for COVID-19.

METHODS: This was a single-center, retrospective study of 56 COVID-19 infected hospitalized African American males 50+ years of age selected from among non-intensive care unit (ICU) and ICU status patients. Demographics, hospitalization-related variables, and medical history were collected from electronic medical records. Plasma samples collected close to admission (≤2 days) were evaluated for cytokines and renal markers; results were compared to a …