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Articles 1951 - 1980 of 5582
Full-Text Articles in Entire DC Network
University Of Central Florida Graduate Catalog, 2021 - 2022, University Of Central Florida
University Of Central Florida Graduate Catalog, 2021 - 2022, University Of Central Florida
UCF Catalogs
No abstract provided.
Sharksrx Newsletter Summer 2021, Nova Southeastern University
Sharksrx Newsletter Summer 2021, Nova Southeastern University
NSU Sharks Rx
No abstract provided.
Yale Medicine Magazine July 2021, Issue 167, Yale University. School Of Medicine
Yale Medicine Magazine July 2021, Issue 167, Yale University. School Of Medicine
Yale Medicine Magazine - alumni bulletin and magazine
This is the July 2021 issue of Yale Medicine Magazine, issue 167. Prepared in cooperation with the alumni and development offices at the School of Medicine. Earlier volumes are called Yale School of Medicine alumni bulletins, dating from v.1 (1953) through v.13 (1965) and Yale Medicine: alumni bulletin of the School of Medicine, v.1 (1965) through v. 52, no.1. (Autumn 2017).
School Of Nursing Newsletter Summer 2021, Southern Adventist University
School Of Nursing Newsletter Summer 2021, Southern Adventist University
Southern Nursing - School of Nursing Newsletter
The Summer 2021 issue of the newsletter features information on the new manikans in the Simulation and Skills Labs, COVID-19 task force, and a recently awarded grant.
Going Viral- Using Technology In The Classroom To Show The Spreading Of Viruses, Laura C. Todd, Brooke A. Whitworth
Going Viral- Using Technology In The Classroom To Show The Spreading Of Viruses, Laura C. Todd, Brooke A. Whitworth
Publications
No abstract provided.
Using Social Listening To Inform Integrated Social And Behavior Change Programs In Burkina Faso, Nrupa Jani, Leanne Dougherty, Martha Silva
Using Social Listening To Inform Integrated Social And Behavior Change Programs In Burkina Faso, Nrupa Jani, Leanne Dougherty, Martha Silva
Reproductive Health
No abstract provided.
Improving Health Literacy For Diabetics In A Rural Community, Elissa Purvis
Improving Health Literacy For Diabetics In A Rural Community, Elissa Purvis
Doctor of Nursing Practice Projects
Adults with type II diabetes mellitus need to understand the disease and manage their chronic condition to live a healthy and comfortable life. This project aimed to educate adults with type II diabetes mellitus in self-management of their chronic illness to increase their health literacy to improve their heart health, kidney health, nutrition, and exercise. The project utilized a Doctor of Nursing Practice (DNP) approach to education for adults with type II diabetes mellitus on the disease process.
METHODS: This project is a quality improvement project focused on educating adults with type II diabetes mellitus in managing their chronic conditions …
Using Infographics To Improve Completion Rates Of The Sepsis Protocol Bundle, Stephen Newbern
Using Infographics To Improve Completion Rates Of The Sepsis Protocol Bundle, Stephen Newbern
Doctor of Nursing Practice Projects
Hospitals have sepsis protocols that must be implemented when a patient shows positive signs and symptoms of a septic infection. Nurses learn about sepsis in nursing school and rarely further their education beyond this basic understanding of the disease. So, when nurses fail to comply with organizational instructions outlined within a defined sepsis protocol bundle, this often leads to a progression of severe sepsis in a patient and, most likely, increased cost for the healthcare facility. Multiple sepsis protocol bundle failures negatively impact organizational ratings established by The Joint Commission for patient care and are highly associated with increased sepsis …
Re-Educating Healthcare Workers In Long-Term Care Facilities To Improve Hand Hygiene Compliance, Jennifer A. Ukeje
Re-Educating Healthcare Workers In Long-Term Care Facilities To Improve Hand Hygiene Compliance, Jennifer A. Ukeje
Doctor of Nursing Practice Projects
Hand hygiene is one of the most significant measures for protecting nursing home residents from healthcare-associated infections (HAIs). An estimated 1.6 million to 3.8 million infections occur each year; of these infections, 32% of all healthcare-associated infections (HAIs) are urinary tract infections (UTI), 15% are pneumonia (lung infection), and 14% are bloodstream infections. The high incidence of HAIs in nursing homes is due to multiple factors such as understaffing, inadequately trained staff, staff to resident ratio, lack of antibiotics stewardship, and the increasing clinical complexity of the average nursing home. In addition, most long- term care (LTC) residents are older …
Can Provision Of Additional Education For Nursing Staff Increase Breastfeeding Knowledge And Feelings Of Self-Efficacy?, Akeba Deqwan Thompson
Can Provision Of Additional Education For Nursing Staff Increase Breastfeeding Knowledge And Feelings Of Self-Efficacy?, Akeba Deqwan Thompson
Doctor of Nursing Practice Projects
Background: Post-partum nurses are responsible for preparing new mothers with the necessary skills to feed and care for their infants and need proper education to effectively and confidently discuss feeding options with their patients.
Purpose: This quality improvement project aims to increase nursing knowledge of breastfeeding and their feeling of self-efficacy in promoting breastfeeding as an option to new mothers.
Design Methods: A quasi-experimental design including a pre-test/post-test used to quantify the effect of education on therapeutic communication, nursing responsiveness, and feelings of self-efficacy.
Conclusion: An overall increase in feelings of self-efficacy and knowledge of breastfeeding was noted amongst nursing …
Implementing An Antibiotic Stewardship Education Program To Decrease Antibiotic Prescriptions In An Urgent Care Clinic, James Gramling
Implementing An Antibiotic Stewardship Education Program To Decrease Antibiotic Prescriptions In An Urgent Care Clinic, James Gramling
Doctor of Nursing Practice Projects
Antibiotics are often prescribed for respiratory infections. These infections often have a viral rather than a bacterial source. Overuse of antibiotics is associated with increased potential for adverse effects, increased healthcare costs, and increasing antibiotic resistance. The purpose of this DNP project was to determine if implementing an antibiotic stewardship program at an urgent care clinic would decrease the number of antibiotic prescriptions written for acute respiratory tract infections. An educational session consisting of didactic and PowerPoint presentations was provided to each provider at the urgent care clinic. Medical records were reviewed for four weeks after completion of the session …
Differences In Student Perceptions With Virtual Clinical Simulation, Melissa Wheeles
Differences In Student Perceptions With Virtual Clinical Simulation, Melissa Wheeles
Doctor of Nursing Practice Projects
Background: Simulation has been a part of nursing education since its inception, with virtual clinical simulation gaining expanded use since the Coronavirus Pandemic. Once considered only a supplemental teaching method, this form of education has become an imperative means of program progression for nursing students when hospital clinical spaces are limited.
Purpose: The purpose of the study is to evaluate potential differences in nursing student perceptions of anxiety and self-confidence with clinical decision making in virtual clinical simulation compared to traditional face-to-face clinicals.
Design Methods: A descriptive, quantitative study using the NASC-CDM© tool completed by 5th (final) semester …
Improving Patient Outcomes With Post-Op Education For Nurses Caring For Patients Undergoing Total Joint Replacement, Amanda Collier
Improving Patient Outcomes With Post-Op Education For Nurses Caring For Patients Undergoing Total Joint Replacement, Amanda Collier
Doctor of Nursing Practice Projects
Background: Surgical site infections (SSI) are the third most reported nosocomial infection causing an increased length of stay, increased healthcare cost, and a substantial increase in morbidity. A SSI is an infection developing within 30 days of surgery without using an implant and within one year of surgery utilizing any form of implant. Typically SSI occurs at the time of incision. However, poor postoperative wound care can lead to an SSI.
Purpose: This project aims to educate nursing staff on care of the total joint replacement (TJR) patient to reduce readmission rates for postoperative SSI.
Design Methods: This …
Methods Of Educating Nursing Students On Proper Handwashing To Enhance Infection Control During The Covid Pandemic, Yulanda King
Methods Of Educating Nursing Students On Proper Handwashing To Enhance Infection Control During The Covid Pandemic, Yulanda King
Doctor of Nursing Practice Projects
Background: Medical professionals have commonly been urged to use soap and water to sanitize their hands to prevent contamination and disease transmission. However, thorough handwashing requires a couple of minutes to clean hands thoroughly. Considering that health professionals must sanitize their hands' multiply times during a day, handwashing consumes a significant amount of time away from bedside care. Time spent away from patients may also result in a substantial decrease in the quality of healthcare services provided by the medical institution.
Purpose: This project evaluates the current policy and procedure for appropriate use of handwashing versus hand sanitizer in the …
A Brief Report Of The Prevalence Of Chronic And Acute Health Conditions Among Blind American Adults, Nazanin M. Heydarian, Yessenia Castro, Osvaldo F. Morera
A Brief Report Of The Prevalence Of Chronic And Acute Health Conditions Among Blind American Adults, Nazanin M. Heydarian, Yessenia Castro, Osvaldo F. Morera
School of Social Work Faculty Publications
Background: Prior research demonstrates disparities in the prevalence of certain chronic and acute health conditions among persons who are blind (PWB) compared to non-blind persons, such as diabetes and infectious diseases. However, a comprehensive understanding of the prevalence of chronic and acute health conditions among PWB is currently lacking.
Objective: The present study addressed this gap by examining the prevalence of chronic and acute conditions among blind persons, and examining differences by gender.
Methods: The present study surveyed 410 PWB residing in the U.S. about their health conditions and activities. Lifetime prevalence for eight chronic and six acute health conditions …
Biographical Feature: Karen C. Carroll, M.D., Erik Munson
Biographical Feature: Karen C. Carroll, M.D., Erik Munson
Clinical Lab Sciences Faculty Research and Publications
No abstract provided.
Oral Manifestations Of Tuberculosis, Diana V. Macri, Sandra Castellanos, Elvir Dincer
Oral Manifestations Of Tuberculosis, Diana V. Macri, Sandra Castellanos, Elvir Dincer
Publications and Research
This article will update the reader on tuberculosis and its oral manifestations.
After decades of decreasing incidence, tuberculosis resurgence is being seen in some global regions due to factors that include the human immunodeficiency virus (HIV) epidemic, increased immigration from countries with endemic tuberculosis, transmission of tuberculosis in crowded or unsanitary environments, and poor healthcare infrastructure. Additionally, this review is especially prescient considering the increasing prevalence of drug-resistant tuberculosis.
A Yeast Expressed Rbd-Based Sars-Cov-2 Vaccine Formulated With 3m-052-Alum Adjuvant Promotes Protective Efficacy In Non-Human Primates, Maria Pino, Talha Abid, Susan Pereira Ribeiro, Venkata Viswanadh Edara, Katharine Floyd, Justin C. Smith, Muhammad Bilal Latif, Gabriela Pacheco-Sanchez, Debashis Dutta, Shelly Wang, Sanjeev Gumber, Shannon Kirejczyk, Joyce Cohen, Rachelle L. Stammen, Sherrie M. Jean, Jennifer S. Wood, Fawn Connor-Stroud, Jeroen Pollet, Wen Hsiang Chen, Junfei Wei, Bin Zhan, Jungsoon Lee, Zhuyun Liu, Ulrich Strych, Neeta Shenvi, Kirk Easley, Daniela Weiskopf, Alesandro Sette
A Yeast Expressed Rbd-Based Sars-Cov-2 Vaccine Formulated With 3m-052-Alum Adjuvant Promotes Protective Efficacy In Non-Human Primates, Maria Pino, Talha Abid, Susan Pereira Ribeiro, Venkata Viswanadh Edara, Katharine Floyd, Justin C. Smith, Muhammad Bilal Latif, Gabriela Pacheco-Sanchez, Debashis Dutta, Shelly Wang, Sanjeev Gumber, Shannon Kirejczyk, Joyce Cohen, Rachelle L. Stammen, Sherrie M. Jean, Jennifer S. Wood, Fawn Connor-Stroud, Jeroen Pollet, Wen Hsiang Chen, Junfei Wei, Bin Zhan, Jungsoon Lee, Zhuyun Liu, Ulrich Strych, Neeta Shenvi, Kirk Easley, Daniela Weiskopf, Alesandro Sette
School of Graduate Studies Faculty Publications
Ongoing SARS-CoV-2 vaccine development is focused on identifying stable, cost-effective, and accessible candidates for global use, specifically in low and middle-income countries. Here, we report the efficacy of a rapidly scalable, novel yeast expressed SARS-CoV-2 specific receptor-binding domain (RBD) based vaccine in rhesus macaques. We formulated the RBD immunogen in alum, a licensed and an emerging alum adsorbed TLR-7/8 targeted, 3M-052-alum adjuvants. The RBD+3M-052-alum adjuvanted vaccine promoted better RBD binding and effector antibodies, higher CoV-2 neutralizing antibodies, improved Th1 biased CD4+T cell reactions, and increased CD8+ T cell responses when compared to the alum-alone adjuvanted vaccine. RBD+3M-052-alum induced a significant …
Range-Wide Declines Of Northern Spotted Owl Populations In The Pacific Northwest: A Meta-Analysis, Alan B. Franklin, Katie M. Dugger, Damon B. Lesmeister, Raymond J. Davis, J. David Wiens, Gary C. White, James D. Nichols, James E. Hines, Charles B. Yackulic, Carl J. Schwarz, Steven H. Ackers, L. Steven Andrews, Larissa L. Bailey, Robin Bown, Jesse Burgher, Kenneth P. Burnham, Peter C. Carlson, Tara Chestnut, Mary M. Conner, Krista E. Dilione, Eric D. Forsman, Elizabeth M. Glenn, Scott A. Gremel, Keith A. Hamm, Dale R. Herter, J. Mark Higley, Rob B. Horn, Julianna M. Jenkins, William L. Kendall, David W. Lamphear, Christopher Mccafferty, Trent L. Mcdonald, Janice A. Reid, Jeremy T. Rockweit, David C. Simon, Stan G. Sovern, James K. Swingle, Heather Wise
Range-Wide Declines Of Northern Spotted Owl Populations In The Pacific Northwest: A Meta-Analysis, Alan B. Franklin, Katie M. Dugger, Damon B. Lesmeister, Raymond J. Davis, J. David Wiens, Gary C. White, James D. Nichols, James E. Hines, Charles B. Yackulic, Carl J. Schwarz, Steven H. Ackers, L. Steven Andrews, Larissa L. Bailey, Robin Bown, Jesse Burgher, Kenneth P. Burnham, Peter C. Carlson, Tara Chestnut, Mary M. Conner, Krista E. Dilione, Eric D. Forsman, Elizabeth M. Glenn, Scott A. Gremel, Keith A. Hamm, Dale R. Herter, J. Mark Higley, Rob B. Horn, Julianna M. Jenkins, William L. Kendall, David W. Lamphear, Christopher Mccafferty, Trent L. Mcdonald, Janice A. Reid, Jeremy T. Rockweit, David C. Simon, Stan G. Sovern, James K. Swingle, Heather Wise
United States Department of Agriculture Wildlife Services: Staff Publications
The northern spotted owl (Strix occidentalis caurina) inhabits older coniferous forests in the Pacific Northwest and has been at the center of forest management issues in this region. The immediate threats to this federally listed species include habitat loss and competition with barred owls (Strix varia), which invaded from eastern North America. We conducted a prospective meta-analysis to assess population trends and factors affecting those trends in northern spotted owls using 26 years of survey and capture-recapture data from 11 study areas across the owls' geographic range to analyze demographic traits, rates of population change, and occupancy parameters for spotted …
Forgiveness Of Dolutegravir-Based Triple Therapy Compared With Older Antiretroviral Regimens: A Prospective Multicenter Cohort Of Adherence Patterns And Hiv-Rna Replication, Jean Jacques Parienti, Anna L. Fournier, Laurent Cotte, Marie Paule Schneider, Manuel Etienne, Guillemette Unal, Philippe Perré, Jean Jacques Dutheil, Elodie Morilland-Lecoq, Fabien Chaillot, David R. Bangsberg, Amandine Gagneux-Brunon
Forgiveness Of Dolutegravir-Based Triple Therapy Compared With Older Antiretroviral Regimens: A Prospective Multicenter Cohort Of Adherence Patterns And Hiv-Rna Replication, Jean Jacques Parienti, Anna L. Fournier, Laurent Cotte, Marie Paule Schneider, Manuel Etienne, Guillemette Unal, Philippe Perré, Jean Jacques Dutheil, Elodie Morilland-Lecoq, Fabien Chaillot, David R. Bangsberg, Amandine Gagneux-Brunon
OHSU-PSU School of Public Health Faculty Publications and Presentations
Average adherence (Av-Adh) and log-transformed treatment interruption (TI) to ARV were prospectively measured over 6 months using electronic drug monitoring (EDM) in several cohorts of PWH. Multivariate linear regression models including baseline confounders explored the influence of EDM-defined adherence (R2) on 6-month log10 HIV-RNA. Multivariate logistic regression models were used to compare the risk of HIV-RNA detection (VR) within subgroups stratified by lower (≤95%) and higher (>95%) Av-Adh.
Three hundred ninety-nine PWH were analyzed with different ARVs: dolutegravir (n = 102), raltegravir (n = 90), boosted PI (bPI; n = 107), and NNRTI (n = 100). …
Targeting Modern Pathogens With Rational Drug Design, Michael Dominic Sacco
Targeting Modern Pathogens With Rational Drug Design, Michael Dominic Sacco
USF Tampa Graduate Theses and Dissertations
Since the first living organisms appeared on earth, their very existence was dependent on their ability to contend for resources. To this day, organisms are perpetually competing for resources, and in doing so, have evolved highly effective defense mechanisms and systems for propagation. Although invisible to the eye, we live in a world teeming with microbes and viruses. While many are harmless, others cause widespread disease. One of the key niches for these pathogens, particularly bacteria, are health-care facilities. These health-care facilities have a high concentration of immunocompromised patients and rely heavily on antibiotics, which strongly contributes to antibiotic resistance. …
Amazon Robotic Service (Ars), Patil Girija, John Mareena, Jin Fenny, Kandula Swapna, Ketsaraporn Kaewkhiaolueang
Amazon Robotic Service (Ars), Patil Girija, John Mareena, Jin Fenny, Kandula Swapna, Ketsaraporn Kaewkhiaolueang
Engineering and Technology Management Student Projects
Warehouse robots are the most effective replacement to minimize the pressure and availability of manual labor. The warehouse robots are mainly used for heavy lifting, picking up packages, transporting, and other tasks in the facility. The growing market of Internet of Things, Artificial Intelligence, and machine learning in the warehouse industry is forecasted to grow in the robots market in the near future. In order to build the final product i.e technology roadmap our team did market research, analysed competitors for the company, identified target customers, analyzed market, product and pricing strategy and at the end came up with the …
Adverse Childhood Experiences And Adult Cardiometabolic Risk Factors And Disease Outcomes: Cross-Sectional, Populationbased Study Of Adults In Rural Uganda, Andrew Wooyoung Kim, Bernard Kakuhikire, Charles Baguma, Crystal M. North, Emily N. Satinsky, Jessica M. Perkins, Patience Ayebare, Allen Kiconco, Elizabeth Namara, David R. Bangsberg, Multiple Additional Authors
Adverse Childhood Experiences And Adult Cardiometabolic Risk Factors And Disease Outcomes: Cross-Sectional, Populationbased Study Of Adults In Rural Uganda, Andrew Wooyoung Kim, Bernard Kakuhikire, Charles Baguma, Crystal M. North, Emily N. Satinsky, Jessica M. Perkins, Patience Ayebare, Allen Kiconco, Elizabeth Namara, David R. Bangsberg, Multiple Additional Authors
OHSU-PSU School of Public Health Faculty Publications and Presentations
Background: Cardiovascular diseases (CVD) pose a major threat to public health in sub-Saharan African communities, where the burden of these classes of illnesses is expected to double by 2030. Growing research suggests that past developmental experiences and early life conditions may also elevate CVD risk throughout the life course. Greater childhood stress and adversity are consistently associated with a range of adult CVDs and associated risk factors, yet little research exists on the long-term effects of early life stress on adult physical health outcomes, especially CVD risk, in sub-Saharan African contexts. This study aims to evaluate the associations between adverse …
Development Of Vaccines And Antivirals Against Zika Virus, Aryamav Pattnaik
Development Of Vaccines And Antivirals Against Zika Virus, Aryamav Pattnaik
School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research
The re-emergence of Zika virus (ZIKV), an arbovirus, poses a major global human health concern because of its ability to cause congenital abnormalities and neurological diseases. While many candidate vaccines and antiviral drugs are in the developmental pipeline, none have been approved for use against ZIKV infection. This dissertation describes the characterization of one vaccine and two antiviral drug candidates against ZIKV infection. A bacterial ferritin-based nanoparticle vaccine, termed zDIII-F, is designed to display multiple copies of ZIKV E protein domain III on its surface. These stable nanoparticles are shown to induce robust antibody-mediated protection against lethal ZIKV infection in …
Post-Discharge Healthcare Utilization In Infants With Neonatal Opioid Withdrawal Syndrome, Shikhar Shrestha, Melissa H Roberts, Jessie R Maxwell, Lawrence M Leeman, Ludmila N Bakhireva
Post-Discharge Healthcare Utilization In Infants With Neonatal Opioid Withdrawal Syndrome, Shikhar Shrestha, Melissa H Roberts, Jessie R Maxwell, Lawrence M Leeman, Ludmila N Bakhireva
Pediatrics Research and Scholarship
The opioid epidemic in the United States has led to a significant increase in the incidence of neonatal opioid withdrawal syndrome (NOWS); however, the understanding of long-term consequences of NOWS is limited. The objective of this study was to evaluate post-discharge healthcare utilization in infants with NOWS and examine the association between NOWS severity and healthcare utilization. A retrospective cohort design was used to ascertain healthcare utilization in the first year after birth-related discharge using the CERNER Health Facts® database. ICD-9/ICD-10 diagnostic codes were used to identify live births and to classify infants into two study groups: NOWS and uncomplicated …
Functional And Phenotypic Evaluation Of Murine Cytomegalovirus Infection Of The Heart, Cassandra Marie Bonavita
Functional And Phenotypic Evaluation Of Murine Cytomegalovirus Infection Of The Heart, Cassandra Marie Bonavita
LSU Doctoral Dissertations
Human Cytomegalovirus (HCMV) is a ubiquitous pathogen which infects 50-90% of the world population and results in lifelong latent infection with periodic transient reactivations. In immunocompetent populations acute infection is generally asymptomatic but seropositivity is associated with many chronic diseases, including cardiovascular disease. Despite 139 years of research into HCMV pathogenesis there is still no licensed vaccine and many gaps in the general knowledge of the virus. This includes the role of long term infection as it pertains to chronic diseases. In these studies, murine cytomegalovirus (MCMV) was used as a model of HCMV pathogenesis in the heart. MCMV shares …
Tennessee Advisory Council On Workers' Compensation, Corrected Annual Report For July 1, 2020 - June 30, 2021, Tennessee. Department Of Treasury.
Tennessee Advisory Council On Workers' Compensation, Corrected Annual Report For July 1, 2020 - June 30, 2021, Tennessee. Department Of Treasury.
Worker's Compensation Reports
No abstract provided.
Testing A Bite-Shortened Hook To Minimize Fish Handling In A Recreational Fishery, Holden E. Harris, Brian K. Whalen, Andrew G. Gude, Michael S. Allen
Testing A Bite-Shortened Hook To Minimize Fish Handling In A Recreational Fishery, Holden E. Harris, Brian K. Whalen, Andrew G. Gude, Michael S. Allen
United States Department of Agriculture Wildlife Services: Staff Publications
Discard mortality can make fishing unsustainable, even in catch-and-release or highly regulated fisheries. However, fishing practices and gears that minimize hook injury, handling, and air exposure can considerably improve fitness and survival in released fish. This study tested whether modified hooks could allow anglers to successfully land and then release fish in the water and without handling. Standard, barbless, and bite-shortened hooks were used to catch Spotted Seatrout Cynoscion nebulosus (n > 75 per hook type), and logistic models were used to assess the differences in landing success and hook self-release success by hook type and categorical fish size. Average landing …
The Impact Of Covid-19-Related Media Coverage On The Return And Volatility Connectedness Of Cryptocurrencies And Fiat Currencies, Zaghum Umar, Francisco Jareño, María De La O González
The Impact Of Covid-19-Related Media Coverage On The Return And Volatility Connectedness Of Cryptocurrencies And Fiat Currencies, Zaghum Umar, Francisco Jareño, María De La O González
All Works
This research explores the impact of COVID-19-related media coverage on the dynamic return and volatility connectedness of the three dominant cryptocurrencies (Bitcoin (BTC), Ethereum (ETH) and Ripple (XRP)) and the fiat currencies of the euro, GBP and Chinese yuan. The sample period covers the first and second devasting waves of the COVID-19 pandemic crisis and ranges from January 1, 2020, to December 31, 2020. The dynamic return and volatility connectedness measures are estimated using the time varying parameter-VAR approach. Our return connectedness analysis shows that the media coverage index (only before the first wave) and the cryptocurrencies are the net …
Can Structural Differences Between Sars-Cov And Sars-Cov-2 Explain Differences In Drug Efficacy?, Bhaskara R. Jasti, Sridivya Raparla, Xiaoling Li
Can Structural Differences Between Sars-Cov And Sars-Cov-2 Explain Differences In Drug Efficacy?, Bhaskara R. Jasti, Sridivya Raparla, Xiaoling Li
School of Pharmacy Faculty Articles
The severe acute respiratory syndrome corona virus (SARS-CoV)and severe acute respiratory syndrome corona virus-2 (SARS-CoV-2), both virus spike proteins are recognized by the cell surface receptors, human angiotensin converting enzyme-2 (ACE-2).These viruses gain access into the host cell through ACE-2receptors.The main aim of the current study was to elaborate on the structural differences in the receptor binding domain (RBD) of spike glycoprotein in SARS-CoV and SARS-CoV-2 that bind at the same active binding site. The crystal structures of receptor bound spikes of SARS-CoV and SARS-CoV-2 were compared using UCSF Chimera and pyMOL software which revealed significant differences in the receptor …