Digital Commons Network^™

Universities As Open Knowledge Institutions: Sharing Vital Research, Katie Wilson, Lucy Montgomery, Cameron Neylon, Richard Hosking, Chun-Kai (Karl) Huang, Rebecca N. Handcock, Alkim Ozaygen, Aniek Roelofs

Proceedings of the IATUL Conferences

Universities are key creators of knowledge. Ensuring that research outputs are not inaccessible behind paywalls, and that research data can be interrogated and built upon is central to efforts to improve the effectiveness of global research landscapes. Mandating and promoting open science and open access (OA) for published research outputs and sharing research data are important elements of building a vibrant open knowledge system, but there are additional benefits. Supporting diversity within knowledge-making institutions; enabling collaboration between universities and communities; addressing inequalities in access to knowledge resources and opportunities for contributing to knowledge making are also important. New tools are …

Capacity Building For A New Multicenter Network Within The Echo Idea States Pediatric Clinical Trials Network, Robert D. Annett, Scott Bickel, John C. Carlson, Kelly Cowan, Sara Cox, Mark J. Fisher, J. Dean Jarvis, Alberta S. Kong, Jessica S. Kosut, Kurtis R. Kulbeth, Abbot Laptook, Pearl A. Mcelfish, Mary M. Mcnally, Lee M. Pachter, Barbara A. Pahud, Lee A. Pyles, Jennifer Shaw, Kari Simonsen, Jessica Snowden, Christine B. Turley, Andrew M. Atz

Journal Articles: Pediatrics

Introduction: Research capacity building is a critical component of professional development for pediatrician scientists, yet this process has been elusive in the literature. The ECHO IDeA States Pediatric Clinical Trials Network (ISPCTN) seeks to implement pediatric trials across medically underserved and rural populations. A key component of achieving this objective is building pediatric research capacity, including enhancement of infrastructure and faculty development. This article presents findings from a site assessment inventory completed during the initial year of the ISPCTN. Methods: An assessment inventory was developed for surveying ISPCTN sites. The inventory captured site-level activities designed to increase clinical trial research …

Community Needs Assessment For Mclean County, Hannah Lynn Curry

Theses and Dissertations

A community needs assessment was conducted for McLean County, Illinois assessing the community level resources that are in place for ex-offenders reintegrating into the community and further resources that are needed. The purposive sample included 7 local agencies that provided a range of reentry services. Intensive interviewing was conducted with respondents of local agencies. Audio-recordings of interviews were transcribed, coded through software and analyzed. Results indicated that boundary spanners and mental health services are the common types of resources in place for ex-offenders in McLean County. Further resources that are needed include housing, employment and mental health services.

Battle Rock: Anatomy Of A Massacre, Adam R. Fitzhugh

Dissertations and Theses

On June 9, 1851, nine men under the direction of a steamboat captain and land speculator named William Tichenor landed on the southern coast of the Oregon Territory at present-day Port Orford with the intention of establishing a permanent settlement. Tichenor's plan was to establish a commercial port that would supply gold mining endeavors in the interior. The landing party's instructions were to survey the townsite while Tichenor traveled to San Francisco to gather more men and supplies. Before departing, he promised the group he would return in exactly two weeks. He also assured them that the local Quatomah Indians, …

Real-World, Multicenter Experience With Meropenem-Vaborbactam For Gram-Negative Bacterial Infections Including Carbapenem-Resistant Enterobacterales And Pseudomonas Aeruginosa, Lee Amaya

All Publications

Background: We aimed to describe the clinical characteristics and outcomes of patients treated with meropenem-vaborbactam (MEV) for a variety of gram-negative infections (GNIs), primarily including carbapenem-resistant Enterobacterales (CRE).

Methods: This is a real-world, multicenter, retrospective cohort within the United States between 2017 and 2020. Adult patients who received MEV for ≥72 hours were eligible for inclusion. The primary outcome was 30-day mortality. Classification and regression tree analysis (CART) was used to identify the time breakpoint (BP) that delineated the risk of negative clinical outcomes (NCOs) and was examined by multivariable logistic regression analysis (MLR).

Results: Overall, 126 patients were evaluated …

The Role Of Interspecies Recombination In The Evolution Of Antibiotic-Resistant Pneumococci, Joshua C. D'Aeth, Mark Pg Van Der Linden, Lesley Mcgee, Herminia De Lencastre, Paul Turner, Jae-Hoon Song, Stephanie W. Lo, Rebecca A. Gladstone, Gps Consortium, Sadia Shakoor

Department of Pathology and Laboratory Medicine

Multidrug-resistant Streptococcus pneumoniae emerge through the modification of core genome loci by interspecies homologous recombinations, and acquisition of gene cassettes. Both occurred in the otherwise contrasting histories of the antibiotic-resistant S. pneumoniae lineages PMEN3 and PMEN9. A single PMEN3 clade spread globally, evading vaccine-induced immunity through frequent serotype switching, whereas locally circulating PMEN9 clades independently gained resistance. Both lineages repeatedly integrated Tn916-type and Tn1207.1-type elements, conferring tetracycline and macrolide resistance, respectively, through homologous recombination importing sequences originating in other species. A species-wide dataset found over 100 instances of such interspecific acquisitions of resistance cassettes and flanking …

Capacity Building For A New Multicenter Network Within The Echo Idea States Pediatric Clinical Trials Network., Robert D. Annett, Scott Bickel, John C. Carlson, Kelly Cowan, Sara Cox, Mark J. Fisher, J Dean Jarvis, Alberta S. Kong, Jessica S. Kosut, Kurtis R. Kulbeth, Abbot Laptook, Pearl A. Mcelfish, Mary M. Mcnally, Lee M. Pachter, Barbara A. Pahud, Lee A. Pyles, Jennifer Shaw, Kari Simonsen, Jessica Snowden, Christine B. Turley, Andrew M. Atz

Manuscripts, Articles, Book Chapters and Other Papers

Introduction: Research capacity building is a critical component of professional development for pediatrician scientists, yet this process has been elusive in the literature. The ECHO IDeA States Pediatric Clinical Trials Network (ISPCTN) seeks to implement pediatric trials across medically underserved and rural populations. A key component of achieving this objective is building pediatric research capacity, including enhancement of infrastructure and faculty development. This article presents findings from a site assessment inventory completed during the initial year of the ISPCTN.

Methods: An assessment inventory was developed for surveying ISPCTN sites. The inventory captured site-level activities designed to increase clinical trial research …

Early Detection Of Wildlife Morbidity And Mortality Through An Event-Based Surveillance System, Terra R. Kelly, Pranav S. Pandit, Nicole Carion, Devin F. Dombrowski, Krysta H. Rogers, Stella C. Mcmillin, Deana L. Clifford, Anthony Riberi, Michael H. Ziccardi, Erica L. Donnelly-Greenan, Christine K. Johnson

Faculty Research, Scholarly, and Creative Activity

The ability to rapidly detect and respond to wildlife morbidity and mortality events is critical for reducing threats to wildlife populations. Surveillance systems that use pre-diagnostic clinical data can contribute to the early detection of wildlife morbidities caused by a multitude of threats, including disease and anthropogenic disturbances. Here, we demonstrate proof of concept for use of a wildlife disease surveillance system, the 'Wildlife Morbidity and Mortality Event Alert System', that integrates pre-diagnostic clinical data in near real-time from a network of wildlife rehabilitation organizations, for early and enhanced detection of unusual wildlife morbidity and mortality events. The system classifies …

Phenotypic And Functional Signatures Of Peripheral Blood And Spleen Compartments Of Cynomolgus Macaques Infected With T. Cruzi: Associations With Cardiac Histopathological Characteristics, Renato Sathler-Avelar, Danielle Marquete Vitelli-Avelar, Armanda Moreira Mattoso-Barbosa, Marcelo Antônio Pascoal-Xavier, Silvana Maria Elói-Santos, Ismael Artur Da Costa-Rocha, Andréa Teixeira-Carvalho, Edward J. Dick Jr, Jane F. Vandeberg, John L. Vandeberg, Olindo Assis Martins-Filho

School of Medicine Publications

We performed a detailed analysis of immunophenotypic features of circulating leukocytes and spleen cells from cynomolgus macaques that had been naturally infected with Trypanosoma cruzi, identifying their unique and shared characteristics in relation to cardiac histopathological lesion status. T. cruzi-infected macaques were categorized into three groups: asymptomatic [CCC(-)], with mild chronic chagasic cardiopathy [CCC(+)], or with moderate chronic chagasic cardiopathy [CCC(++)]. Our findings demonstrated significant differences in innate and adaptive immunity cells of the peripheral blood and spleen compartments, by comparison with non-infected controls. CCC(+) and CCC(++) hosts exhibited decreased frequencies of monocytes, NK and NKT-cell subsets in …

Board Of Registered Nursing, Kendra J. Muller, Debra Jorgensen, Bridget Fogarty Gramme

California Regulatory Law Reporter

No abstract provided.

2021-07-13_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated twice a week on Tuesdays and Fridays.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, …

Post-Acute Sequelae Of Covid-19 And Polypharmacy: If You Think There’S Too Much Polypharmacy Now, Just Wait, Demetra Antimisiaris

The University of Louisville Journal of Respiratory Infections

The intersection of increased chronic disease burden worldwide with the COVID-19 pandemic was called the “perfect storm”. This article discusses yet another perfect storm: Post COVID-19 (acute and non-acute) syndrome, high chronic disease burdens, advanced age, and polypharmacy. The expected hyper polypharmacy that should result from the added disease and symptom burden due to post COVID-19 syndrome is discussed, as well as the importance of studying the incidence and characteristics to be able to address avoidable medication-related problems.

Covid-19 Newsletter (Vol. 80), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

The Effects On Public Health Of Climate Change Adaptation Responses: A Systematic Review Of Evidence From Low- And Middle-Income Countries., Pauline F D Scheelbeek, Alan D. Dangour, Stephanie Jarmul, Grace Turner, Anne J. Sietsma, Jan C. Minx, Max Callaghan, Idowu Ajibade, Stephanie E. Austin, Robbert Biesbroek, Kathryn J. Bowen, Tara Chen, Katy Davis, Tim Ensor, James D. Ford, Eranga K. Galappaththi, Elphin T. Joe, Issah J. Musah-Surugu, Gabriela Nagle Alverio, Patricia Nayna Schwerdtle, Pratik Pokharel, Eunice A. Salubi, Giulia Scarpa, Alcade C. Segnon, Mariella Siña, Sienna Templeman, Jiren Xu, Carol Zavaleta-Cortijo, Lea Berrang-Ford

Geography Faculty Publications and Presentations

Climate change adaptation responses are being developed and delivered in many parts of the world in the absence of detailed knowledge of their effects on public health. Here we present the results of a systematic review of peer-reviewed literature reporting the effects on health of climate change adaptation responses in low- and middle-income countries (LMICs). The review used the 'Global Adaptation Mapping Initiative' database (comprising 1682 publications related to climate change adaptation responses) that was constructed through systematic literature searches in Scopus, Web of Science and Google Scholar (2013-2020). For this study, further screening was performed to identify studies from …

Temporal Trends And Drivers Of Mountain Lion Depredation In California, Usa, Justin A. Dellinger, Daniel K. Macon, Jaime L. Rudd, Deana L. Clifford, Steven G. Torres

Human–Wildlife Interactions

Increasing human populations and expanding development across the globe necessitate continual progress in understanding and mitigating human–wildlife conflict. California, USA has the largest human population and at least half of the state is suitable mountain lion (Puma concolor) habitat. The juxtaposition of high human abundance within and adjacent to mountain lion habitat make California relevant for understanding human–large carnivore conflict. We compiled 7,719 confirmed incidents of mountain lions depredating domestic animals over a 48-year period (1972–2019) to examine temporal trends in mountain lion depredations as well as factors influencing annual depredation rates at the county level. Linear regressions …

Covid-19 Pandemic: A Mixed-Methods Study Investigation Of A Health Science System Faculty's Adaptations To An Online (Non-Traditional) Teaching Environment For Health Professional Students, Daryl Philip Lofaso

LSU Doctoral Dissertations

The purpose of this mixed method study was to explore the transition to an online educational platform for future health professional students at a southern health sciences system due to Severe Acute Respiratory Syndrome (SARS-CoV-2) virus. The majority of health professional students received their education via face-to-face prior to the pandemic. The pandemic altered their traditional pedagogical method of face-to-face to online instruction. The health professional school faculty offer the best instruction in a lecture hall not on a computer screen using Zoom. This study was designed to analyze how the faculty adapted in moving to an online instructional method, …

Review Of Sexual Health Issues Linked With Cardiovascular Disease And Type 2 Diabetes Mellitus In Aboriginal And Torres Strait Islander Males, Veronica Collins, Tamara J. Swann, Jane Burns, Tim Moss, Mick Adams

Australian Indigenous HealthBulletin

There are well established links between male sexual health conditions and chronic disease, particularly cardiovascular disease (CVD) and type 2 diabetes (T2DM). Erectile dysfunction (ED) and low testosterone are two sexual health conditions that are relatively common among the wider male population. However, there is a lack of data specifically about these sexual problems among Aboriginal and Torres Strait Islander males.

One of the most important findings of research regarding the links between sexual health and chronic disease is that ED can be a risk marker for future CVD or undiagnosed T2DM. Understanding these links can lead to more holistic …

Altmetric For Top Three Covid-19 Research Articles Published In 2020 - An Overview, Stephen G

Library Philosophy and Practice (e-journal)

Around the world, researchers are working together to understand COVID-19. Knowing who’s talking about related research and what’s being said is critical to this effort. Altmetric put together resources to help the navigate altmetric data and evaluate the quality of discussions around corona virus literature. The objective of this study is to determine the top three research articles related with Covid-19 and published in 2020. Based on altmetric attention score “The proximal origin of SARS-CoV-2” is the first rank article out of three and it’s published in Nature journal. It has highly mentioned in News Stories, blog posts …

Episode 4: Darin Edwards ’97 ’10ms ’11phd: Developing The Moderna Covid-19 Vaccine, University Of Central Florida

Knights Do That Podcast Transcripts

In this week’s Knights Do That episode, we speak with UCF grad Darin Edwards '97 '10MS '11PhD, director of immunology at Moderna.

Edwards earned his bachelor’s degree in biology, master’s degree in master’s degree in molecular biology and doctorate in biomedical sciences with a focus on neuroscience at UCF in 2011 and has an impressive resume including, most recently leading the research and development for the COVID-19 vaccine. Edwards discusses what it was like working on the COVID-19 vaccine, the moment it was released and what he looks forward to most as we approach a return to pre-pandemic work and …

Baricitinib In The Treatment Of A Critical Patient With Covid-19 Pneumonia: A Case Report, Nishant Patel, Dylan Goldsmith, Forest W. Arnold

The University of Louisville Journal of Respiratory Infections

A 72-year-old male presented to the emergency department with a chief complaint of diarrhea after having tested positive for COVID-19 two days prior. He initially had minimal respiratory complaints, but was eventually transferred to the intensive care unit for acute hypoxic respiratory failure. In addition to dexamethasone, remdesivir, and antibiotics, the patient was treated with baricitinib, a Janus kinase inhibitor that was recently granted emergency use authorization by the Food and Drug Administration for treatment of hospitalized patients with COVID-19. He had an extensive and complicated hospital course and had to be placed on mechanical ventilation, ultimately undergoing tracheostomy. After …

The Mother's Lived Experience Of Breastfeeding In The First 4 Weeks Postpartum: A Heideggerian Hermeneutic Phenomenological Analysis, Stacy Rosales

Dissertations

The purpose of this study was to more fully understand, in their own words, the experiences of mothers who began breastfeeding their infant after birth and may or may not have been breasting at four weeks postpartum. A single research question guided this study: What are the lived experiences of breastfeeding mothers during the first four weeks postpartum? Eight mothers who delivered in the past four to six weeks were interviewed. Data were analyzed using a Heideggerian hermeneutic phenomenological approach. This method was chosen because it allowed the researcher to conduct interviews and explore the lived experience of breastfeeding mothers …

Stress And Molecular Drivers For Cancer Progression: A Longstanding Hypothesis, Justin Wendel, A. Verma, Vijian Dhevan, Subhash C. Chauhan, Manish Tripathi

School of Medicine Publications

Stress management is becoming very important part of cancer patient care. Chronic stressors lead to boost tumorigenesis and promote cancer development, recurrence, and drug resistant leading to poor health outcomes. The Hypothalamic-Pituitary-Adrenal (HPA) axis, which is activated by stress, also regulates Hypothalamic-Pituitary-Thyroid (HPT) axis. Stress related changes in immune function and inflammatory response also leads to reduced immune surveillance resulting in tumorigenesis. This article explores the hormonal axis impacted by stress and how chronic stress can lead to poor outcome of a cancer patient.

2021-07-10_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated twice a week on Tuesdays and Fridays.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, …

Identification Of A Ruminant Origin Group B Rotavirus Associated With Diarrhea Outbreaks In Foals, Tirth Uprety, Chithra C. Sreenivasan, Ben M. Hause, Ganwu Li, Solomon O. Odemuyiwa, Stephan Locke, Jocelynn Morgan, Li Zeng, William F. Gilsenan, Nathan Slovis, Laurie Metcalfe, Craig N. Carter, Peter J. Timoney, David W. Horohov, Dan Wang, Erdal Erol, Emma Adam, Feng Li

Maxwell H. Gluck Equine Research Center Faculty Publications

Equine rotavirus group A (ERVA) is one of the most common causes of foal diarrhea. Starting in February 2021, there was an increase in the frequency of severe watery to hemorrhagic diarrhea cases in neonatal foals in Central Kentucky. Diagnostic investigation of fecal samples failed to detect evidence of diarrhea-causing pathogens including ERVA. Based on Illumina-based metagenomic sequencing, we identified a novel equine rotavirus group B (ERVB) in fecal specimens from the affected foals in the absence of any other known enteric pathogens. Interestingly, the protein sequence of all 11 segments had greater than 96% identity with group B …

County Youth Athletics Response To Covid-19 Pandemic, Elise Schaller

Dissertations

Problem: To ensure safe participation in youth athletics and prevent COVID-19 transmission during the COVID-19 pandemic, St. Louis County Department of Public Health (DPH) implemented Youth Sports Guidelines on October 14, 2020. This project aimed to identify level of adherence to precautions listed in the guidelines at six county public high school athletic events.

Methods: An observational descriptive study design was used to monitor guideline adherence at high school athletic events. Two observers tallied violations by participants and spectators to Youth Sports Guidelines at St. Louis County public high school athletic events. Six high-frequency contact (basketball and wrestling) events …

Impact Of Social Isolation In Hiv-Positive Individuals During A Pandemic, Corina Jane Bakoylis

Dissertations

Problem: The global pandemic of COVID-19 caused concern for immunocompromised individuals. The purpose of this quality improvement initiative was to assess the impact of social isolation on feelings of loneliness, depression, and social isolation experiences in HIV-positive individuals residing in a long-term care facility.

Methods: A mixed-method convergent design with a purposeful sample of HIV-positive adult residents residing in a long-term care facility was utilized. An evaluation of loneliness using the University of California Los Angeles (UCLA) Loneliness Scale (Version 3) and depression using the Patient Health Questionnaire-8 (PHQ-8) were completed. Personal experiences were also assessed with five predetermined open-ended …

July 9, 2021 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

The Economic Impact Of Lockdowns: A Theoretical Assessment, Gabriele Camera, Alessandro Gioffré

ESI Working Papers

The sudden appearance of the SARS-CoV-2 virus and the onset of the COVID-19 pandemic triggered extreme and open-ended “lockdowns” to manage the disease. Should these drastic interventions be the blueprint for future epidemics? We construct an analytical framework, based on the theory of random matching, which makes explicit how epidemics spread through economic activity. Imposing lockdowns by assumption prevents contagion and reduces healthcare costs, but also disrupts income-generation processes. We characterize how lockdowns impact the contagion process and social welfare. Numerical analysis suggests that protracted, open-ended lockdowns are generally suboptimal, bringing into question the policy responses seen in many countries.

Impact Of Duration Of Antibiotic Prophylaxis On Rates Of Surgical Site Infection (Ssi) In Patients Undergoing Mastectomy Without Immediate Reconstruction, Comparing A Single Prophylactic Dose Versus Continued Antibiotic Prophylaxis Postoperatively: A Multicentre, Double-Blinded Randomised Control Trial Protocol, Abida K. Sattar, Nida Zahid, Hania Shahzad, Rufina Soomro, Omema Saleem, Syed Faisal Mahmood

Department of Surgery Docs

Introduction: In breast surgeries, prophylactic antibiotics given before the surgical incision as per Joint Commission Surgical Care Improvement Project guidelines have been shown to decrease the rate of postoperative infections. There is, however, no clear consensus on postoperative antibiotic prophylaxis in patients undergoing mastectomy with indwelling drains. This trial protocol proposes to study the difference in rates of surgical site infection (SSI) with or without continuation of postoperative antibiotics in patients undergoing mastectomy without immediate reconstruction and with indwelling drains.
Methods and analysis: In this multicentre, double-blinded clinical trial, all patients undergoing mastectomy (without immediate reconstruction) will receive a single …

Jordan’S Response In Mitigating The Covid-19 Pandemic: The Impact Of Public Policy In Addressing A Pandemic, Tamador Alzghol

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

The world is currently facing one of the most rapidly spreading pandemics of our time, swift actions by governments in controlling the spread of the virus in their countries is determined by the number of cases recorded. This Global pandemic has moved governments in an uncertain space due to the rapid and almost uncontrollable spread of the virus once it hits a community. The Hashemite Kingdom of Jordan is commended for the quick action taken to control and overcome the spread of the COVID-19 virus within its lands. This article discusses the approach Jordan uses to control the spread of …