Digital Commons Network^™

No Ordinary Proteins: Adsorption And Molecular Orientation Of Monoclonal Antibodies, Ankit D. Kanthe, Andrew Ilott, Mary Krause, Songyan Zheng, Jinjiang Li, Wei Bu, Mrinal K. Bera, Binhua Lin, Charles Maldarelli, Raymond S. Tu

Publications and Research

The interaction of monoclonal antibodies (mAbs) with air/water interfaces plays a crucial role in their overall stability in solution. We aim to understand this behavior using pendant bubble measurements to track the dynamic tension reduction and x-ray reflectivity to obtain the electron density profiles (EDPs) at the surface. Native immunoglobulin G mAb is a rigid molecule with a flat, “Y” shape, and simulated EDPs are obtained by rotating a homology construct at the surface. Comparing simulations with experimental EDPs, we obtain surface orientation probability maps showing mAbs transition from flat-on Y-shape configurations to side-on or end-on configurations with increasing concentration. …

Potential Immunomodulatory Properties Of Biologically Active Components Of Spices Against Sars-Cov-2 And Pan Β-Coronaviruses, Sourodip Sengupta, Debina Bhattacharyya, Grishma Kasle, Souvik Karmakar, Omkar Sahu, Anirban Ganguly, Sankar Addya, Jayasri Das Sarma

Kimmel Cancer Center Faculty Papers

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced COVID-19 has emerged as a defining global health crisis in current times. Data from the World Health Organization shows demographic variations in COVID-19 severity and lethality. Diet may play a significant role in providing beneficial host cell factors contributing to immunity against deadly SARS-CoV-2 pathogenesis. Spices are essential components of the diet that possess anti-inflammatory, antioxidant, and antiviral properties. Hyperinflammation, an aberrant systemic inflammation associated with pneumonia, acute respiratory failure, and multiorgan dysfunction, is a major clinical outcome in COVID-19. Knowing the beneficial properties of spices, we hypothesize that spice-derived bioactive components …

2021-08-27_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated three times a week on Mondays, Wednesdays, and Fridays.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, …

August 27, 2021 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Covid-19 Vaccines, Somchai Bovornkitti

Asian Medical Journal and Alternative Medicine

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“It’S Like 1998 Again”: Why Parents Still Refuse And Delay Vaccines, Jiana L. Ugale, Heather Spielvogle, Christine Spina, Cathryn Perreira, Ben Katz, Barbara Pahud, Phd Amanda F. Dempsey Md, Jeffrey D. Robinson Phd, Kathleen Garrett Ma, Mph Sean T. O’Leary Md, Mph Douglas J. Opel Md

Communication Faculty Publications and Presentations

We conducted a qualitative study from 2018 to 2019 to update the reasons why US parents’ refuse or delay vaccines. Four focus groups and 4 semi-structured interviews involving 33 primary care pediatric providers were conducted in Washington and Colorado. A thematic analysis was conducted to identify themes related to reasons for parental refusal or delay. Five predominant themes were identified: (1) vaccine safety, (2) relative influence of information sources, decision-makers, and timing, (3) low perceived risk of contracting vaccine-preventable disease, (4) lack of trust, and (5) religious objection. Vaccine safety was the theme mentioned most frequently by providers (N = …

Triangle Journal News, Volume 12, Number 5

Triangle Journal News, 1990-2006

Editors: Allen Cook, John Stilwell, Angela Lamb. Columnists/Contributors: Paula Martinac, Butch Valentine, Romeo San Vicente, Robyn Johnson, Shannon Yarbrough, Angela Lamb, Wayne Beson. Production: Allen Cook, Bob Dumais, John Stilwell. Advertising: Bob Dumais, Allen Cook. National Advertising: Rivendell Marketing Company.

Special thanks to Rhodes College and the Paul Barret Jr. Library for providing initial scanning of this collection.

Infective Endocarditis Secondary To Mycoplasma Pneumoniae, Huzaifa Dawood, Saad Nasir, Reem M. Khair, Mustafa Dawood

Section of Internal Medicine

Mycoplasma pneumoniae (MP) is a gram-positive bacterium most commonly associated with community-acquired pneumonia in adults. It can also involve other systems of the body. Cardiovascular complications include pericarditis, myocarditis, congestive cardiac failure, and, rarely, infective endocarditis. We report a case of infective endocarditis secondary to MP infection in an adult. We treated our patient with doxycycline, which showed significant improvement.

Triangle Journal News, Volume 9, Number 4

Triangle Journal News, 1990-2006

Co-Editors: Allen Cook, John Stilwell. Staff Writers: Vincent Astor, Ira L. King. Contributors: David Bianco, Paula Martinac, Romeo St. Vicente, Butch Valentine, Jim Maynard, Doyle Richmond. Production: Vincent Astor, Allen Cook, Bob Dumais, John Stilwell. Advertising: Vincent Astor, Bob Dumais.

Special thanks to Rhodes College and the Paul Barret Jr. Library for providing initial scanning of this collection.

Covid‑19, Race/Ethnicity, And Age: The Role Of Telemedicine To Close The Gaps On Health Disparities, Andreas Kakolyris, Juan J. Delacruz, Christos I. Giannikos

Publications and Research

The novel COVID-19 outbreak is a major public health challenge that quickly turned into an economic recession of great proportions. This pandemic poses a trade-off between health and the economy where social distancing, quarantines, and isolation shut down demand and supply chains across the USA. This paper analyzes the impact of COVID-19 on illness and death among older adults and communities of color with low socioeconomic status in New York City. To achieve this goal, fractional logit models are used to capture changes in the novel virus’ morbidity and mortality rates at the neighborhood level. Median income, race/ethnicity, age, household …

Penentuan Kadar Protein Albumin Dalam Sampel Brownies Yang Diberikan Kepada Penderita Tuberkulosis, Elfira Maya Sari, Tri Marta Fadhilah

Chimica et Natura Acta

Pembuatan makanan yang mengandung rasa manis sangat banyak diminati oleh beberapa orang mulai dari anak – anak, remaja, dewasa bahkan pun lansia. Salah satunya adalah brownies yang mengandung coklat dan beberapa tambahan bahan pangan lainnya dan sedikit gula sebagai penambah cita rasa. Brownies yang diolah pada penelitian ini adalah brownies yang ditambahkan bahan ikan gabus yang memiliki tinggi protein. Tujuan penelitian ini adalah mengetahui kadar protein albumin pada sampel brownies dengan alat spektrofotometer UV-VIS. Metode penelitian adalah metode bradford dimana ditambahkan reagen CBB agar terbentuk perubahan warna menjadi biru. Sampel yang diuji ada 6 sampel dimana 3 sampel ditambahkan daging …

Mosquito Distribution And West Nile Virus Surveillance Results On The Nevada National Security Site In South-Central Nevada, Derek B. Hall, Vivek Raman

Western North American Naturalist

A 10-year study (2004–2013) was conducted to determine mosquito distribution and the prevalence of West Nile virus (WNV) on the Nevada National Security Site (NNSS) in south-central Nevada. Mosquito traps baited with dry ice were set overnight at sites where standing water provided potential breeding sites for mosquitoes. Captured mosquitoes were identified to species and tested for WNV. A total of 556 mosquitoes representing 6 species were captured and identified at 20 sites around the NNSS during 124 surveys. A vast majority (89%) of mosquitoes were Culex tarsalis. Two samples, both Culiseta inornata, tested positive for WNV in …

Digitalization In The Port Industry From The Perspectives Of Bibliometric Analysis, Xuyuan Sun

World Maritime University Dissertations

No abstract provided.

Triangle Journal News, Volume 11, Number 12

Triangle Journal News, 1990-2006

Editors: Allen Cook, John Stilwell, Angela Lamb. Columnists/Contributors: Paula Martinac, Butch Valentine, Romeo San Vicente, Lorri L. Jean, Shannon Yarbrough, Rawley Grau, Jim Maynard, Angela Lamb. Production: Allen Cook, Bob Dumais, John Stilwell. Advertising: Bob Dumais, Allen Cook. National Advertising: Rivendell Marketing Company.

Special thanks to Rhodes College and the Paul Barret Jr. Library for providing initial scanning of this collection.

Handshake Antimicrobial Stewardship As A Model To Recognize And Prevent Diagnostic Errors., Justin B. Searns, Manon C. Williams, Christine E. Macbrayne, Ann L. Wirtz, Jan E. Leonard, Juri Boguniewicz, Sarah K. Parker, Joseph A. Grubenhoff

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVES: Few studies describe the impact of antimicrobial stewardship programs (ASPs) on recognizing and preventing diagnostic errors. Handshake stewardship (HS-ASP) is a novel ASP model that prospectively reviews hospital-wide antimicrobial usage with recommendations made in person to treatment teams. The purpose of this study was to determine if HS-ASP could identify and intervene on potential diagnostic errors for children hospitalized at a quaternary care children's hospital.

METHODS: Previously self-identified "Great Catch" (GC) interventions by the Children's Hospital Colorado HS-ASP team from 10/2014 through 5/2018 were retrospectively reviewed. Each GC was categorized based on the types of recommendations from HS-ASP, including …

Electronic Medical Record-Based Deep Data Cleaning And Phenotyping Improve The Diagnostic Validity And Mortality Assessment Of Infective Endocarditis: Medical Big Data Initiative Of Cmuh, Hsiu-Yin Chiang, Li-Ying Liang, Che-Chen Lin, Yi-Jin Chen, Min-Yen Wu, Sheng-Hsuan Chen, Pin-Hua Wu, Chin-Chi Kuo, Chih-Yu Chi

BioMedicine

Background

International Classification of Diseases (ICD) code–based claims databases are often used to study infective endocarditis (IE). However, the quality of ICD coding can influence the reliability of IE research. The impact of complementing the ICD-only approach with data extracted from electronic medical records (EMRs) has yet to be explored.

Methods

We selected the information of adult patients with discharge ICD codes for IE (ICD-9: 421, 112.81, 036.42, 098.84, 115.04, 115.14, 115.94, 424.9; ICD-10: I33, I38, I39) during 2005–2016 in China Medical University Hospital. Data extraction was conducted on the basis of the modified Duke criteria to establish a …

Climate Change Will Increase The Vector Capacity Of The Aedes Aegypti In South America: A Systematic Map, Liliana I. Maz, Richard S. Lockwood

PSU McNair Scholars Online Journal

Tropical infectious diseases such as dengue, chikungunya, and Zika affect millions of people annually in all regions of the world. The disease burden propagated by these arboviruses has rapidly increased in recent decades due to the range expansion of their shared vector, the Aedes aegypti mosquito. The IPCC has predicted a global increase in temperatures of 1.4-5.8°C over the next century; understanding how that will affect the vector capacity of the Aedes aegypti is essential for public health planning. This paper examined findings from a systematic map of the current state of research on this increasingly important influence on infectious …

Elopre Named Assistant Dean For Medical Education Diversity & Inclusion, Kendra Carter

Browse All News

No abstract provided.

Why Should People Use Face Masks In The Time Of Covid? The Jri Position, Jose Bordon, Alex Glynn, Forest W. Arnold

The University of Louisville Journal of Respiratory Infections

No abstract provided.

Great (Soft) Power Competition: Us And Chinese Efforts In Global Health Engagement, Michael W. Wissemann

The US Army War College Quarterly: Parameters

Global health engagement, an underutilized strategy rooted in the strengths of soft power persuasion, can lead to more military-to-military cooperation training, help establish relationships that can be relied on when crises develop, stabilize fragile states, and deny violent extremist organizations space for recruiting and operations. Examining Chinese efforts worldwide to curry favor and influence and the challenges posed by the COVID-19 pandemic, this article shows health as a medium is a very compelling and advantageous whole-of-government approach to national security policy concerns.

Progression Of Sars-Cov-2 Seroprevalence In St. Louis, Missouri, Through January 2021, Brittany K Smith, Andrew B Janowski, Arim C Fremont, Lucas J Adams, Ya-Nan Dai, Christopher W Farnsworth, Ann M Gronowski, Stephen M Roper, David Wang, Daved H Fremont

Open Access Publications

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seropositivity was assessed for 3,066 individuals visiting hospitals in St. Louis, Missouri, during July 2020, November 2020, or January 2021. Seropositivity in children increased from 5.22% in July to 21.16% in January. In the same time frame, seropositivity among adults increased from 4.52% to 19.03%, prior to initiation of mass vaccination.

Predictive Accuracy And Densitometric Analysis Of Point-Of-Care Immunoassay For Adenoviral Conjunctivitis, Spencer D Johnson, Mary K Migneco, Mathew S Margolis, Leonard W Haertter, Julia B Huecker, Richard S Buller, Gregory A Storch, Mae O Gordon, Et Al

Open Access Publications

Purpose: Accurate diagnosis of adenoviral conjunctivitis (Ad-Cs) is important for timely and appropriate patient management to reduce disease transmission. This study assessed the diagnostic accuracy of a commercially available point-of-care adenovirus immunoassay and determined whether its predictive accuracy is influenced by signal intensities of test result bands.

Methods: Point-of-care immunoassay (AdenoPlus) testing and quantitative polymerase chain reaction (qPCR) testing was performed on conjunctival swab samples obtained from eyes of 186 eligible adult participants with presumed infectious conjunctivitis and symptoms of ≤4 days. Masked observers assessed signal intensities of the immunoassay test and control bands using densitometry.

Results: Ad-Cs was confirmed …

Understanding The Mechanistic Roles Of Integrin Alpha 6 In Tumor Development Using A Humanized Zebrafish (Danio Rerio) Model System, Ashley B. Williams

Honors College Theses

Present day cancer incidence and mortality rates indicate the need for effective cancer diagnostic tools and targeted cancer therapeutic strategies. Recent studies have focused on the biological pathways of cells and tumor microenvironments to identify putative biomarkers and potential drug targets as diagnostic and therapeutic tools. Human integrins, adhesion receptors, have become the focal points in these studies, specifically Integrin Alpha 6 (ITGA6) which has been implicated in major tumor progression roles: metastasis and angiogenesis. These characteristics make ITGA6 an excellent candidate for potential drug or diagnostic target, however, the mechanism by which ITGA6 facilitates tumor progression remains unclear. Cell …

2021-08-24_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated three times a week on Mondays, Wednesdays, and Fridays.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, …

August 24, 2021 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Triangle Journal News, Volume 9, Number 2

Triangle Journal News, 1990-2006

Co-Editors: Allen Cook, John Stilwell. Staff Writers: Vincent Astor, Ira L. King. Contributors: David Bianco, Dr. Simon LeVay, Romeo St. Vicente, Butch Valentine, Jim Maynard, Doyle Richmond. Production: Vincent Astor, Allen Cook, Bob Dumais, John Stilwell. Advertising: Vincent Astor, Bob Dumais.

Special thanks to Rhodes College and the Paul Barret Jr. Library for providing initial scanning of this collection.

Green Synthesized Honokiol Transfersomes Relieve The Immunosuppressive And Stem-Like Cell Characteristics Of The Aggressive B16f10 Melanoma, Shady Swidan, Yasmeen Ezzeldeen, Aya Sebak, Aliaa N. Elmeshad

Pharmacy

Background

Honokiol (HK) is a natural bioactive compound with proven antineoplastic properties against melanoma. However, it shows very low bioavailability when administered orally. Alternatively, topical administration may offer a promising route. The objective of the current study was to fabricate HK transfersomes (HKTs) for topical treatment of melanoma. As an ultradeformable carrier system, transfersomes can overcome the physiological barriers to topical treatment of melanoma: the stratum corneum and the anomalous tumor microenvironment. Moreover, the immunomodulatory and stemness-regulation roles of HKTs were the main interest of this study.

Methods

TFs were prepared using the modified scalable heating method. A three-factor, three-level …

Covid-19 Newsletter (Vol. 86), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

Triangle Journal News, Volume 8, Number 12

Triangle Journal News, 1990-2006

Co-Editors: Allen Cook, John Stilwell. Staff Writers: Vincent Astor, Ira L. King. Contributors: David Bianco, Dr. Simon LeVay, Romeo St. Vicente, Butch Valentine, Dottie Jones, Jim Norcross, Doyle Richmond. Production: Vincent Astor, Allen Cook, Bob Dumais, John Stilwell. Advertising: Vincent Astor, Bob Dumais.

Special thanks to Rhodes College and the Paul Barret Jr. Library for providing initial scanning of this collection.

Convergent Antibody Responses To The Sars-Cov-2 Spike Protein In Convalescent And Vaccinated Individuals, Elaine C Chen, Emma S Winkler, Rita E Chen, Michael S Diamond, Et Al

Open Access Publications

Unrelated individuals can produce genetically similar clones of antibodies, known as public clonotypes, which have been seen in responses to different infectious diseases, as well as healthy individuals. Here we identify 37 public clonotypes in memory B cells from convalescent survivors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or in plasmablasts from an individual after vaccination with mRNA-encoded spike protein. We identify 29 public clonotypes, including clones recognizing the receptor-binding domain (RBD) in the spike protein S1 subunit (including a neutralizing, angiotensin-converting enzyme 2 [ACE2]-blocking clone that protects in vivo) and others recognizing non-RBD epitopes that bind the …