Digital Commons Network^™

Prevention And Screening Of Hpv Malignancies, Kristina R Dahlstrom, Andrew T Day, Erich M Sturgis

Faculty, Staff and Students Publications

It is estimated that 5% of the global cancer burden, or approximately 690,000 cancer cases annually, is attributable to human papillomavirus (HPV). Primary prevention through prophylactic vaccination is the best option for reducing the burden of HPV-related cancers. Most high-income countries (HICs) have introduced the HPV vaccine and are routinely vaccinating adolescent boys and girls. Unfortunately, although they suffer the greatest morbidity and mortality due to HPV-related cancers, many lower- and middle-income countries (LMICs) have been unable to initiate and sustain vaccination programs. Secondary prevention in the form of screening has led to substantial declines in cervical cancer incidence in …

Estimating The Effects Of Race And Social Vulnerability On Hospital Admission And Mortality From Covid-19, Joshua M Landman, Karen Steger-May, Karen E Joynt Maddox, Gmerice Hammond, Aditi Gupta, Adriana M Rauseo, Min Zhao, Randi E Foraker

2020-Current year OA Pubs

OBJECTIVE: To estimate the risk of hospital admission and mortality from COVID-19 to patients and measure the association of race and area-level social vulnerability with those outcomes.

MATERIALS AND METHODS: Using patient records collected at a multisite hospital system from April 2020 to October 2020, the risk of hospital admission and the risk of mortality were estimated for patients who tested positive for COVID-19 and were admitted to the hospital for COVID-19, respectively, using generalized estimating equations while controlling for patient race, patient area-level social vulnerability, and time course of the pandemic.

RESULTS: Black individuals were 3.57 as likely (95% …

Redbird Scholar, Vol. 7, No. 1 (Fall 2021), Illinois State University, Office Of The Vice President For Research And Graduate Studies

Redbird Scholar

No abstract provided.

Covid-19 One Year On: Security And Privacy Review Of Contact Tracing Mobile Apps, Wei Yang Ang, Lwin Khin Shar

Research Collection School Of Computing and Information Systems

The ongoing COVID-19 pandemic caused 3.8 million deaths since December 2019. At the current vaccination pace, this global pandemic could persist for several years. Throughout the world, contact tracing (CT) apps were developed, which play a significant role in mitigating the spread of COVID-19. This work examines the current state of security and privacy landscape of mobile CT apps. Our work is the first attempt, to our knowledge, which provides a comprehensive analysis of 70 CT apps used worldwide as of year Q1 2021. Among other findings, we observed that 80% of them may have handled sensitive data without adequate …

Blindspotting And Covid: The Gentrification Of Racism, Ashley Starr-Morris

Journal of Religion & Film

The novel Coronavirus is not only exposing old patterns of racism and systemic inequalities, but deepening them as well. The notion of blindspotting, as described in the film by the same name, is used to understand how the COVID-19 pandemic impacts the “spiritual emergency” or crisis of racism in America. "Blindspotting" is an image or situation that can be interpreted in two ways but is understood by some in only one way, thereby producing a blind spot. In 2020 and 2021, we see segments of American society, from politics to white Christian nationalism, upholding a sacred canopy of exceptionalism by …

Medical Outcomes, Quality Of Life, And Family Perceptions For Outpatient Vs Inpatient Neutropenia Management After Chemotherapy For Pediatric Acute Myeloid Leukemia, Kelly D Getz, Julia E Szymczak, Yimei Li, Rachel Madding, Yuan-Shung V Huang, Catherine Aftandilian, Staci D Arnold, Kira O Bona, Emi Caywood, Anderson B Collier, M Monica Gramatges, Meret Henry, Craig Lotterman, Kelly Maloney, Amir Mian, Rajen Mody, Elaine Morgan, Elizabeth A Raetz, Jeffrey Rubnitz, Anupam Verma, Naomi Winick, Jennifer J Wilkes, Jennifer C Yu, Brian T Fisher, Richard Aplenc

Department of Medicine Faculty Papers

Importance: Pediatric acute myeloid leukemia (AML) requires multiple courses of intensive chemotherapy that result in neutropenia, with significant risk for infectious complications. Supportive care guidelines recommend hospitalization until neutrophil recovery. However, there are little data to support inpatient over outpatient management.

Objective: To evaluate outpatient vs inpatient neutropenia management for pediatric AML.

Design, setting, and participants: This cohort study used qualitative and quantitative methods to compare medical outcomes, patient health-related quality of life (HRQOL), and patient and family perceptions between outpatient and inpatient neutropenia management. The study included patients from 17 US pediatric hospitals with frontline chemotherapy start dates ranging …

Model Systems To Study The Chronic, Polymicrobial Infections In Cystic Fibrosis: Current Approaches And Exploring Future Directions, George A. O’Toole, Aurélie Crabbé, Rolf Kümmerli, John J. Lipuma, Jennifer M. Bomberger, Jane C. Davies, Dominique Limoli, Vanessa V. Phelan, James B. Bliska, William H. Depas, Lars E. Dietrich, Thomas H. Hampton, Ryan Hunter, Cezar M. Khursigara, Alexa Price-Whelan, Alix Ashare, Robert A. Cramer, Joanna B. Goldberg, Freya Harrison, Deborah A. Hogan

Dartmouth Scholarship

A recent workshop titled “Developing Models to Study Polymicrobial Infections,” sponsored by the Dartmouth Cystic Fibrosis Center (DartCF), explored the development of new models to study the polymicrobial infections associated with the airways of persons with cystic fibrosis (CF). The workshop gathered 351 investigators over two virtual sessions. Here, we present the findings of this workshop, summarize some of the challenges involved with developing such models, and suggest three frameworks to tackle this complex problem. The frameworks proposed here, we believe, could be generally useful in developing new model systems for other infectious diseases. Developing and validating new approaches to …

Understanding The Effect Of Dietary Palmitic Acid On Glycolysis During Innate Immune Memory In Macrophages, Khaleda A. Aqaei

University Honors Theses

Trained immunity is long-term innate immune memory induced by a primary stimulus, which leads to hyper-inflammation upon secondary stimulation with a homologous or heterologous ligand. Trained immunity is mediated by epigenetic and metabolic reprogramming of the target cell and leads to modification of gene expression and cellular function. Classically, trained immunity is initiated by β-glucans, an inflammatory molecule found on the exterior of fungal species. Interestingly, our lab has recently described that dietary fatty acids can initiate trained immunity, working through similar pathways as β-glucans. Specifically, our data show that a pre-treatment with a specific dietary saturated fatty acid (SFA), …

Data-Driven Clustering Identifies Features Distinguishing Multisystem Inflammatory Syndrome From Acute Covid-19 In Children And Adolescents., Alon Geva, Manish M. Patel, Margaret M. Newhams, Cameron C. Young, Mary Beth F. Son, Michele Kong, Aline B. Maddux, Mark W. Hall, Becky J. Riggs, Aalok R. Singh, John S. Giuliano, Charlotte V. Hobbs, Laura L. Loftis, Gwenn E. Mclaughlin, Stephanie P. Schwartz, Jennifer E. Schuster, Christopher J. Babbitt, Natasha B. Halasa, Shira J. Gertz, Sule Doymaz, Janet R. Hume, Tamara T. Bradford, Katherine Irby, Christopher L. Carroll, John K. Mcguire, Keiko M. Tarquinio, Courtney M. Rowan, Elizabeth H. Mack, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Philip C. Spinella, Mary A. Staat, Katharine N. Clouser, Vijaya L. Soma, Heda Dapul, Mia Maamari, Cindy Bowens, Kevin M. Havlin, Peter M. Mourani, Sabrina M. Heidemann, Steven M. Horwitz, Leora R. Feldstein, Mark W. Tenforde, Jane W. Newburger, Kenneth D. Mandl, Adrienne G. Randolph, Overcoming Covid-19 Investigators

Manuscripts, Articles, Book Chapters and Other Papers

Background: Multisystem inflammatory syndrome in children (MIS-C) consensus criteria were designed for maximal sensitivity and therefore capture patients with acute COVID-19 pneumonia.

Methods: We performed unsupervised clustering on data from 1,526 patients (684 labeled MIS-C by clinicians)clusters, followed by recursive feature elimination to identify characteristics of potentially misclassified MIS-C-labeled patients.

Findings: Of 94 clinical features tested, 46 were retained for clustering. Cluster 1 patients (N = 498; 92% labeled MIS-C) were mostly previously healthy (71%), with mean age 7·2 ± 0·4 years, predominant cardiovascular (77%) and/or mucocutaneous (82%) involvement, high inflammatory biomarkers, and mostly SARS-CoV-2 PCR negative (60%). Cluster …

Transmission Event Of Sars-Cov-2 Delta Variant Reveals Multiple Vaccine Breakthrough Infections, Timothy Farinholt, Harsha Doddapaneni, Xiang Qin, Vipin Menon, Qingchang Meng, Ginger Metcalf, Hsu Chao, Marie-Claude Gingras, Vasanthi Avadhanula, Paige Farinholt, Charu Agrawal, Donna M Muzny, Pedro A Piedra, Richard A Gibbs, Joseph Petrosino

Faculty, Staff and Students Publications

BACKGROUND: This study aims to identify the causative strain of SARS-CoV-2 in a cluster of vaccine breakthroughs. Vaccine breakthrough by a highly transmissible SARS-CoV-2 strain is a risk to global public health.

METHODS: Nasopharyngeal swabs from suspected vaccine breakthrough cases were tested for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) by qPCR (quantitative polymerase chain reaction) for Wuhan-Hu1 and alpha variant. Positive samples were then sequenced by Swift Normalase Amplicon Panels to determine the causal variant. GATK (genome analysis toolkit) variants were filtered with allele fraction ≥80 and min read depth 30x.

RESULTS: Viral sequencing revealed an infection cluster of …

Reinvigorating A Technical Countering Weapons Of Mass Destruction Distance Learning Graduate Certificate Program, James C. Petrosky, Gaiven Varshney, Jeremy Slagley, Sara Shaghaghi

Faculty Publications

Current Countering Weapons of Mass Destruction (CWMD) demands can be divided broadly into policy and science. The science of chemical, biological, and radiological/nuclear weapons informs the limits of development, production, employment, operation, detection, risk characterization, human and material protection, and medical intervention. In short, the science of weapons of mass destruction (WMD) should precede and inform the development of policy. It is to this end that the Air Force Institute of Technology (AFIT) CWMD program was re-established, providing a technical educational option for practitioners to understand the science behind a very technically challenging subject.

Vaccination Hesitancy And Conspiracy Beliefs In The Uk During The Covid-19 Pandemic, Alison M. Bacon, Steven Taylor

School of Psychology

BackgroundConspiracy beliefs about vaccination along with vaccination hesitancy are threats to achieving population immunity during the SARS-COV-2 (COVID-19) pandemic. This longitudinal study aimed to clarify the association between these and non-monetary incentives to vaccination in the UK.MethodData were collected at three points: (1) before and (2) after the development of a vaccine and (3) after the vaccination programme was underway. At Time 1, participants completed measures of general and COVID-19-specific concerns about vaccination and belief in conspiracy theories. At times 2 and 3, participants reported their intentions whether or not to have the SARS-CoV-2 vaccine. Those who were hesitant provided …

Covid-19 Vaccine Diplomacy In West Africa: Empathetic Soft-Power Or Neocolonial Intentions?, Mary Sperrazza

Independent Study Project (ISP) Collection

With the impending roll-out of COVID-19 vaccines, many questions have been raised concerning the roll-out of the vaccines beyond the Global North. While some countries across the Global South have been able to purchase limited numbers of vaccines; many countries in the Global South remain highly or entirely dependent on various programs for the distribution of vaccines, such as the COVID-19 Vaccines Global Access (COVAX) program. Another means of distribution is of individual countries of the Global North that have either higher purchasing power or are producers of one or more vaccines that have begun donating an allocated amount of …

The Labyrinth Of Data Collection For Humanitarian Project Funding And Implementation, Maria Alejandra Pulido

Independent Study Project (ISP) Collection

My research concentrates on four NGOs: IOM, IDMC, JIPS, and OCHA which use different tools to collect data and translate the information into evidence for data-driven decision making (DDDM) for the implementation of humanitarian assistance projects. I focus on the importance, advantages, and various data collection tools which help ameliorate the humanitarian sector since it does not have a current professionalized path to enter the workforce. I incorporated four interviews, attended two conferences and analyzed multiple online sources during my project.

Evaluating The Pragmatic And Moralistic Approach To Drug Policy And Addiction In Opioid Epidemic Outcomes, Brielle Seidel

Independent Study Project (ISP) Collection

Drug use, policy and outcomes differ in all countries; however, trends exist in response to these circumstances and can typically be evaluated through a pragmatic and moralistic lens. The public health, and evidence-based pragmatic approach differs from the law enforcement-centered moralistic approach, specifically in outcomes of people suffering from substance use disorder. Particularly for opioid use disorder, countries that have taken the pragmatic approach in response to opioid epidemics have had dramatic results. Two of the countries discussed include Switzerland and Portugal, with additional information on the Netherlands. In contrast, current opioid epidemics exist in certain countries who maintain a …

Analysis Of The Moroccan Government & Ngos Responses To Migrant Health Crisis, Jepchirchir Mutwol

Independent Study Project (ISP) Collection

Healthcare access in Morocco for migrants has been a topic of growing interest. With the implementation of migration reforms in response to Morocco becoming a destination for migrants, it is important to assess the effectiveness of government policies in aiding migrant health. Additionally, assessing other political actors' influence in government policies is equally important. Through research of existing scholarship, I theorize that the biggest issue impacting migrant access to health is the illegalization of migrants. Without being a legal resident, let alone in asylum or a refugee, migrants cannot access public health services without the fear of deportation. Local and …

Helmintos Transmitidos Por El Suelo En Ecuador; La Respuesta Comunitaria Y Las Percepciones A Ellos En Baños Y Puyo, Audrey Chesney

Independent Study Project (ISP) Collection

This investigation was a qualitative study focused on soil-transmitted helminths (STHs) in Baños and Puyo, Ecuador. The perceptions of the communities regarding STHs and the community response to STH and STH infections was studied. The objectives of this study aimed to discover and learn about the perceptions of STHs from the affected communities, to comprehend the barriers that are present against better treatment for STH infections, and to learn about the community action taking place to improve the situation of soil-transmitted helminths (STHs) in the community. Soil transmitted helminths are intestinal worms that are transmitted through the contamination of the …

Comparación Entre Las Percepciones Médicas Y Psicológicas De La Diabetes Tipo 2 Y La Tuberculosis En El Ecuador, Héctor Ortiz

Independent Study Project (ISP) Collection

Research Question: What are the differences and similarities between the perceptions of the medical and psychological management of both type 2 diabetes and tuberculosis? Objectives: The principal objective of this study is to understand the perceptions behind DM2 and TB as well as how these perceptions affect the care of these diseases. Secondary objectives are to define the epidemiological transition, describe the medical and psychological management and care of DM2 and TB, analyze how the people perceive the management and psychological care of DM2 and TB, and analyze the comparison of the perceptions of both diseases. Background: The epidemiological transition …

New Considerations In Designing The Circulation Elements To Reduce Covid 19 Infection, Sara Chamass, Selim Kilani, Anas Mattar

Architecture and Planning Journal (APJ)

As a result of the global pandemic recession of COVID-19, cities have imposed several restrictions to control this outbreak by closing their frontiers and forcing social distancing. The conjecture has arisen as to how architecture could be entirely influenced. This field is involved in finding solutions to reduce the spread of this pandemic which became a new issue. Unfortunately, due to the shortage of the movable and flexible circulation elements, the considerations and architectural preventive measures taken were affected during the planning of the post-pandemic built-environment. This paper, therefore, aims to propose a checklist of new design considerations for the …

Cutaneous Anthrax In Gunung Kidul, Yogyakarta: A Case Report, Riswanto Riswanto, Dhani Redhono, Evi Nurhayatun

Jurnal Penyakit Dalam Indonesia

Bacillus anthracis is an aerobic, gram-positive, and spore-forming Bacillus species. The most common form of anthrax infection is the cutaneous form. The infection usually develops several days after exposure to products of infected animals and manifest as a black sore with severe swelling on the skin. In this report, a 60-year-old man with a black and swollen lesion on her index finger presented in Gunung Kidul in December 2019. ELISA antibody anthrax serum was performed. The patient was then treated with antibiotics after diagnosis. This patient had a history of contact with the beef of a slaughtered sheep. The patient …

Anti-Sars-Cov-2 Monoclonal Antibodies For Early Covid-19: A Real-World Experience, Katherine Belden, Md, Bryan Hess, Md, Caroline Brugger, Crnp, Rachel Carr, Pa, Todd Braun, Md, Joseph Derose, Do, John Zurlo, Md

Division of Infectious Diseases and Environmental Medicine Posters

Higher rates of COVID-19 related hospitalization and death are reported in patients with underlying health conditions and advanced age as compared to the general population.While polyclonal immunity generated by vaccines has demonstrated protection against severe disease, vaccine response takes time and may be inadequate in some high-risk populations.1 Treatment with anti-SARS-CoV-2 neutralizing monoclonal antibodies affords prompt, passive humoral immunity and has been shown in randomized, controlled trials to reduce rates of hospitalization and death from COVID-19 in high-risk ambulatory patients treated early in the course of infection.2,3 The U.S. Food and Drug Administration (FDA) has issued Emergency Use Authorization for …

Conjunctional Concepts: The Conceptual Teaching Technique In Biology Classes, Igor V. Zaitsev

Publications and Research

Conceptual teaching relies on concepts in conjunction with a bigger conceptual category (or categories). Revealing and using conceptual conjunctions in the science classroom means teaching conceptually. To make conceptual teaching more accessible to biology instructors, a three-concept model was described to be used during a lecture. This model has allowed the author to develop a relatively simple method that starts with an active concept or concepts, then introduces conjunctional and supporting concepts to relate the content to other concepts and relevant real-world applications. This method is intended to help instructors in preparing to teach biological concepts conceptually, in order to …

Why Are Our Covid Safety Strategies Different Than Fall 2020?, Linda Gunter

Browse All News

No abstract provided.

The Influence Of Characteristics And Behavior On The Incidence Of Pulmonary Tuberclosis In Al-Hidayah Pesantren, Kejuruan Muda Subdistric Tamiang District, Aceh Province, 2019, Indah Anggraini, Basaria Hutabarat

Jurnal Penyakit Dalam Indonesia

Introduction. Pulmonary tuberculosis is a chronic infectious disease that is a global issue. Some factors influence the occurrence of pulmonary tuberculosis, among others, the source of infection, a high amount of virulence bacilli, and decreased endurance. This study aims to determine the effect of characteristics and behavior on the incidence of pulmonary TB disease in Al-Hidayah Islamic Boarding School, Vocational School, Aceh Tamiang Regency. Method. This research is analytic with a cross-sectional research design. Data analysis uses Chi-Square test and Logistic Regression) to determine the influence of the most dominant risk factors with pulmonary TB disease incidence. Results. The results …

Diversity In Alzheimer's Disease Drug Trials: The Importance Of Eligibility Criteria, Sanne Franzen, Jade Emily Smith, Esther Van Den Berg, Monica Rivera Mindt, Rozemarijn L. Van Bruchem-Visser, Erin L. Abner, Lon S. Schneider, Niels D. Prins, Ganesh M. Babulal, Janne M. Papma

Sanders-Brown Center on Aging Faculty Publications

INTRODUCTION: To generalize safety and efficacy findings, it is essential that diverse populations are well represented in Alzheimer's disease (AD) drug trials. In this review, we aimed to investigate participant diversity in disease-modifying AD trials over time, and the frequencies of participant eligibility criteria.

METHODS: A systematic review was performed using Medline, Embase, the Cochrane Library, and Clinicaltrials.gov, identifying 2247 records.

RESULTS: In the 101 included AD trials, participants were predominantly White (median percentage: 94.7%, interquartile range: 81.0-96.7%); and this percentage showed no significant increase or decrease over time (2001-2019). Eligibility criteria such as exclusion of persons with psychiatric illness …

The Covid-19 Assessment For Survival At Admission (Casa) Index: A 12 Months Observational Study, Gianluca Bagnato, Daniela La Rosa, Carmelo Ioppolo, Alberta De Gaetano, Marianna Chiappalone, Natalia Zirilli, Valeria Viapiana, Maria Concetta Tringali, Simona Tomeo, Caterina Oriana Aragona, Francesca Napoli, Sara Lillo, Natasha Irrera, William Neal Roberts, Egidio Imbalzano, Antonio Micari, Elvira Ventura Spagnolo, Giovanni Squadrito, Sebastiano Gangemi, Antonio Giovanni Versace

Internal Medicine Faculty Publications

Objective: Coronavirus disease 2019 (COVID-19) is a disease with a high rate of progression to critical illness. However, the stratification of patients at risk of mortality is not well defined. In this study, we aimed to define a mortality risk index to allocate patients to the appropriate intensity of care.

Methods: This is a 12 months observational longitudinal study designed to develop and validate a pragmatic mortality risk score to stratify COVID-19 patients aged ≥18 years and admitted to hospital between March 2020 and March 2021. Main outcome was in-hospital mortality.

Results: 244 patients were included in the study (mortality …

Synthesis And Complexation Of Monotosylated 4-Aminopyridine With Nickel (Ii) And Iron (Ii) Ions, Kingsley John Orie, Remy Ukachukwu Duru, Raphael I-Oro Ngochindo

Makara Journal of Science

Tosylated 4-aminopyridine and other sulfonylated compounds of amines comprise a substantial class of pharmaceutical drugs used as antibiotics in the field of medicine. This research aimed at the synthesis of tosylated 4-aminopyridine and the complexation of the tosyated 4-aminopyridine with Ni(II) and Fe(II) ions. The sulfonamide was prepared by the action of tosyl chloride on 4-aminopyridine in an aqueous alkaline medium. The complexes were synthesized by the reaction of Ni(NO₃)_2.6H₂O /Fe(NO₃)_2.6H₂O with sulfonamide derivative. These compounds were characterized through Ultraviolet Visible spectroscopy (UV–Vis), Fourier Transform Infer-Red (FTIR) spectroscopy, …

Celebrating The Stories Of Black Cellular Biologists And The Path Towards Diversity, Equity, And Inclusion In Stem, Henning Schneider, Nipun Chopra, Kenneth Brown, Scott Stetson, Wendy Tomamichel, Rebecca Kinney, Valerie O'Hair

President Lori S. White Inauguration Symposium

Black scientists have made major contributions to their scientific communities, but their stories and work have not received well-deserved recognition due to systemic inequities within science and academia. By celebrating the stories of Black scientists, we aim to encourage students of color and underrepresented groups to pursue a caree in the natural sciences. Here we tell the stories of Ernest E. Just, Sandra A. Murray and Avery August, three Black cellular biologists from three different generations who have made major contributions to the scientific community using microscopy. The presented project is carried out as part of the Buehler Biomedical Imaging …

Impact Of The Covid-19 Outbreak On Tourists’ Real-Time On-Site Emotional Experience In Reopened Tourism Destinations, Yang Yang, Qian Ruan, Songshan (Sam) Huang, Tian Lan, Ying Wang

Research outputs 2014 to 2021

The COVID-19 pandemic that caused unprecedented havoc on global tourism industry will all blow over, however whether the tourists' real-time on-site emotional experience in the reopened tourism destinations is higher or lower than that of the period before the pandemic outbreak has not been studied. Since this is an important basis for managers to design tourist win-back strategies, this study empirically examines the impact of the COVID-19 outbreak on tourists' real-time on-site emotional experience using geo-tagged check-in user-generated content data in China's National 5A scenic spots from November 7, 2019 to April 8, 2020. Results show that although the COVID-19 …

Factors Affecting The Students’ Re-Use Of The Electronic Learning System (Els), Reynaldo Bautista Jr., Luz Suplico Jeong, Carlo Saavedra, Joseph Sy-Changco

Asia-Pacific Social Science Review

The COVID-19 pandemic has challenged higher education worldwide. From face-to-face sessions between teachers and students, teaching and learning have to be done online to allow students to continue learning while preventing the spread of this infectious disease. Faced with a wide range of electronic learning systems (ELS) to choose from, this study examined the factors that could affect the students’ intent to re-use the ELS. There were 135 college students in a private university in Manila, Philippines, and 177 college students from a public university in Macau, China, who were surveyed to find out the factors that would influence their …