Digital Commons Network^™

Rulifying Reasonable Expectations: How Katz And Originalism Can Work Together To Create A More Determinate Fourth Amendment, Michael Gentithes

Akron Law Faculty Publications

For decades, commentators have decried the Supreme Court’s Fourth Amendment search jurisprudence as a hopelessly confusing jumble. Critics save their harshest barbs for the judicially created “reasonable expectations of privacy” test, suggesting that it provides little guidance and leaves search cases open to wide judicial discretion. Motivated by such critiques, several Justices have recently claimed that an originalist approach could replace the reasonable expectations test, limit judicial discretion, and clarify the Fourth Amendment’s meaning. This Article provides a comprehensive defense of the reasonable expectations test against originalist calls to abandon it. It notes two flaws in the originalist response. First, …

A Global Pandemic Remedy To Vaccine Nationalism, Emily Michiko Morris, Orit Fischman-Afori, Miriam Marcowitz-Bitton

Akron Law Faculty Publications

Recognizing the need for flexibility in times of emergency and building upon knowledge gained from existing international and domestic compulsory licensing laws, we propose a global, centralized scheme to provide access to vaccines during pandemics. In many ways our proposal mirrors some of the World Health Organization's (WHO) COVID-19 vaccine initiatives but consolidates and expands them into a much more efficacious form. Under the proposed model, the WHO's declaration of a pandemic would trigger a global procurement and distribution scheme for vaccines. The proposed scheme would be mandatory and would require that all countries operate as one buyer vis-a-vis vaccine …

Ministry Matters: A Study Of The Relationship Between Campus Ministry And Socialization, Rachel Jean Kitrell

Honors Program Theses

The present study investigated the relationship between involvement in campus ministry and students’ socialization to the university. Campus ministry participants (N=62) representing eight of eleven registered campus ministries completed an online 39-question Qualtrics survey that sought to evaluate their involvement in ministry activities, social involvement in their campus ministry, social involvement in their university, and socialization to the university through history, politics, and goals and values. A significant positive correlation was found between involvement in ministry activities and social involvement in campus ministry as well as between each of the three socialization variables. There were also significant positive correlations found …

South Atlantic Mpas And Oculina Hapc: Characterization Of Benthic Habitat And Biota., Stacey Harter, John K. Reed, Andrew David, Stephanie Farrington, Harbor Branch Oceanographic Institute

Faculty Scholarship

A 14-day research cruise was conducted May 30 to June 12, 2021 by NOAA National Marine Fisheries on the NOAA Ship Pisces with the UNCW Mohawk ROV with a pre-cruise Shelter in Place (SIP. Other collaborators involved include: the Cooperative Institute for Ocean Exploration, Research, and Technology (CIOERT) at Harbor Branch Oceanographic Institute, Florida Atlantic University (HBOI-FAU), and University of North Carolina at Wilmington (UNCW). The South Atlantic Fishery Management Council (SAFMC) established eight deepwater Marine Protected Areas (MPAs) along the outer continental shelf off the southeastern U.S in February 2009 and the Oculina Habitat Area of Particular Concern (OHAPC) …

Detection Of Amyotrophic Lateral Sclerosis Disease By Variational Modedecomposition And Convolution Neural Network Methods From Event-Relatedpotential Signals, Fatma Lati̇foğlu, Firat Orhan Bulucu, Rami̇s İleri̇

Turkish Journal of Electrical Engineering and Computer Sciences

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is a neurological disease that occurs as a result of damage to the nerves in the brain and restriction of muscle movements. Electroencephalography (EEG) is the most common method used in brain imaging to study neurological disorders. Diagnosis of neurological disorders such as ALS, Parkinson's, attention deficit hyperactivity disorder is important in biomedical studies. In recent years, deep learning (DL) models have been started to be applied in the literature for the diagnosis of these diseases. In this study, event-related potentials (ERPs) were obtained from EEG signals obtained as a …

Exploring The Practical Implementation Of Marine Biodiversity Offsetting In Australia, Holly J. Niner, Peter J.S. Jones, Ben Milligan, Craig Styan

School of Biological and Marine Sciences

No abstract provided.

China’S Bilateral Investment Treaties, Heng Wang

Research Collection Yong Pung How School Of Law

This chapter focuses on the changes and trends in Chinese bilateral investment treaties and relatedly investment rules of China’s free trade agreements. It analyzes a number of questions: what is the changing context of China’s bilateral investment rulemaking? How to understand the evolution of China’s bilateral investment treaties? What are the major features in China’s recent practice? What are the shifts on investment dispute settlement?

The Right To Development, Integral Human Development, And Integral Ecology In The Amazon, Diane A. Desierto, Ilaria Schnyder Von Wartensee

Journal Articles

From the Article

This article discusses the reorientation of environmental protection in Amazonia away from the paradigm of individual and collective natural resource management of regional or global commons, to the more radical thesis of Integral Ecology as the vindication of human dignity, environmental stewardship and collective responsibility - a concept deeply related to the Church's own pioneering of Integral Human Development as the 'authentic development development of every person and of the whole person'. Under the concept of integral Ecology, we argue that this expressive elaboration of the Catholic Church's core social teaching of Integral Human Development ultimately hearkens …

Fiduciary Judgment Rules, Julian Velasco

Journal Articles

Because of the strong moral rhetoric and robust equitable remedies available in fiduciary law, it is not surprising to find lawyers and legal scholars seeking to expand the reach of fiduciary law principles into new relationships and new areas of law. However, expansion often does not work very well because of the demanding and pervasive nature of fiduciary duties. Thus, jurists often turn to the business judgment rule and its policy of underenforcement of fiduciary duties as a way to fit fiduciary law principles into other areas of law. The problem with this approach is that it is based on …

Leverage, Randy J. Kozel

Journal Articles

Sometimes government operates by inducement rather than order. Congress distributes money to the states. A state grants funds to nonprofit organizations. An administrative agency offers wages and professional opportunities to its staff. A high school provides instruction to its students. In each situation, the government furnishes something of value. And in each situation, it asks something in return-whether implementation of a government program, forbearance from activities deemed inconsistent with operational goals, conduct in pursuit of an employment mission, or compliance with standards of academic discipline. Though they arise in different contexts, these varied forms of government action present the same …

Roe And Casey Were Grievously Wrong And Should Be Overruled, Charles J. Cooper, Richard W. Garnett, Peter A. Patterson, Brian W. Barnes, John D. Ohlendorf

Journal Articles

This essay, based on an amicus curiae brief filed in the Dobbs case, explains that the Roe and Casey decisions were "grievously wrong", that no traditional stare decisis considerations weigh in favor of retaining them, and that they should be overruled.

The High Cost Of Eviction: Struggling To Contain A Growing Social Problem, Judith Fox

Journal Articles

Matthew Desmond’s Pulitzer Prize winning book, focused public attention on the issue of eviction. As a result, scholars have begun to investigate and challenge some of the assumptions made in the book. Primarily, is eviction the cause of poverty or one of its consequences? This article explores several options in an attempt to explain the high number of evictions in America. These include, among others, the lack of affordable housing, failed governmental policies, the rise of institutional landlords and the role of courts. The article highlights some interventions that have begun to show progress in easing the burden of eviction. …

Moral Truth And Constitutional Conservatism, Gerard V. Bradley

Journal Articles

Conservative constitutionalism is committed to "originalism," that is, to interpreting the Constitution according to its original public understanding. This defining commitment of constitutional interpretation is sound. For decades, however, constitutional conservatives have diluted it with a methodology of restraint, a normative approach to the judicial task marked by an overriding aversion to critical moral reasoning. In any event, the methodology eclipsed originalism and the partnership with moral truth that originalism actually entails. Conservative constitutionalism is presently a melange of mostly unsound arguments against the worst depredations of Casey's Mystery Passage.

The reason for the methodological moral reticence is easy to …

Strategic Implications Of Covid-19: Considerations For Georgia’S Rural Health Providers, Bettye A. Apenteng, Linda Kimsey, Charles Owens, Samuel T. Opoku, Angela Peden, William Mase

Health Policy & Community Health: Faculty Publications

Whether rural hospitals and providers have seen a surge in COVID-19 cases or a reduction in patients seeking care since the pandemic began, their financial condition has been negatively impacted. Many providers have now received some emergency funding through the Coronavirus Aid, Relief, and Economic Security Act and the Payroll Protection Program but these are likely only short-term fixes. For many, the crisis has exacerbated already existing problems. Notable among these problems are volume declines, supply chain disruptions, and workforce concerns. While these problems require immediate action, two longer-term systemic changes to rural healthcare delivery are needed to address them. …

Occupational Therapy Student Perceptions Of Wellness: Focus Group Findings, Kelsey Lawrence, Katherine Chin, Stacy Smallfield

Journal Articles: Occupational Therapy

Despite the evidence of significant consequences stemming from the intense demands on students, most graduate-level programs have insufficiently considered components of students’ wellness. Thus, the purpose of this research study was two-pronged: 1) to evaluate current occupational therapy students’ perceptions of wellness and 2) to explore student perceptions on using communities of practice as a program delivery method to enhance wellness. A qualitative study design was selected to gather experiences and feedback from occupational therapy graduate students. Participants were recruited via email from a convenience sample of a large, research-based Midwestern occupational therapy program. Participants attended one focus group and …

Prerequisites In Behavioral Sciences And Business Revisited A Decade Later: Ongoing Opportunities For Dental Education, Rebecca M. Beckler, Natalie A. Nuckolls, David G. Dunning

Journal Articles: College of Dentistry

Introduction: Ten years ago a study reported on the lack of prerequisites in behavioral sciences and business management for entry into dental college. The primary objective of this follow-up study was to assess the current status of similar prerequisite courses in both U.S. and Canadian dental schools. Materials and Methods: Required and recommended courses in behavioral sciences and in business in each North American dental school's official online publication were analyzed in December 2019. Admissions requirements were readily available in sixty-five of the sixty-eight U.S. dental schools and in all ten schools in Canada; three U.S. schools were contacted by …

Re-Imagining Machine Learning In Dental Research: A Lesson Learned From The Covid-19 Pandemic, Jafar Kolahi, Mohammad Seyedhamzeh, David G. Dunning, Nader Kalbasi

Journal Articles: College of Dentistry

At this time, humankind is experiencing on a global scale a frightening infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of September 25, 2020, more than 32.3 million cases have been reported in 188 countries, resulting in more than 984,000 official reported deaths.^[1],[2] During the course of human history, there have been several pandemics, for example, plague and smallpox. However, one of the main differences between COVID-19 and previous pandemics is the availability of computer-based technologies. Paralleling the global growth of COVID-19, studies using computer-based technologies have emerged (e.g., machine learning) to fight against …

Clinical Activity Of Fianlimab (Regn3767), A Human Anti-Lag-3 Monoclonal Antibody, Combined With Cemiplimab (Anti-Pd-1) In Patients (Pts) With Advanced Melanoma, Guilherme Rabinowits

All Publications

No abstract provided.

The Impact Of Resistance Training On Body Composition, Muscle Strength, And Functional Fitness In Older Women (45-80 Years): A Systematic Review (2010-2020), Lynda B. Ransdell, Heidi A. Wayment, Nanette Lopez, Cori Lorts, Anna L. Schwartz, Karen Pugliesi, Patricia S. Pohl, Dierdra Bycura, Ricky Camplain

Journal Articles: College of Nursing, Niedfelt Nursing Research Center

As women age, they typically experience a progressive decrease in skeletal muscle mass and strength, which can lead to a decline in functional fitness and quality of life. Resistance training (RT) has the potential to attenuate these losses. Although well established for men, evidence regarding the benefits of RT for women is sparse and inconsistent: prior reviews include too few studies with women and do not adequately examine the interactive or additive impacts of workload, modalities, and nutritional supplements on outcomes such as muscle mass (MM), body composition (BC), muscle strength (MS), and functional fitness (FF). The purpose of this …

Assessment Of A Program For Sars-Cov-2 Screening And Environmental Monitoring In An Urban Public School District, John Crowe, Andy T. Schnaubelt, Scott Schmidtbonne, Kathleen Angell, Julia Bai, Teresa Eske, Molly Nicklin, Catherine Pratt, Bailey White, Brodie Crotts-Hannibal, Nicholas Staffend, Vicki L. Herrera, Jeramie Cobb, Jennifer Conner, Julie Carstens, Jonell Tempero, Lori Bouda, Matthew Ray, James V. Lawler, Walter S. Campbell, John-Martin Lowe, Joshua L. Santarpia, Shannon Bartelt-Hunt, Michael R. Wiley, David Brett-Major, Cheryl Logan, M. Jana Broadhurst

Journal Articles: Epidemiology

Importance: Scalable programs for school-based SARS-CoV-2 testing and surveillance are needed to guide in-person learning practices and inform risk assessments in kindergarten through 12th grade settings.

Objectives: To characterize SARS-CoV-2 infections in staff and students in an urban public school setting and evaluate test-based strategies to support ongoing risk assessment and mitigation for kindergarten through 12th grade in-person learning.

Design, Setting, and Participants: This pilot quality improvement program engaged 3 schools in Omaha, Nebraska, for weekly saliva polymerase chain reaction testing of staff and students participating in in-person learning over a 5-week period from November 9 to December 11, 2020. …

Sensing Population Distribution From Satellite Imagery Via Deep Learning:Model Selection, Neighboring Effects, And Systematic Biases, Xiao Huang, Di Zhu, Fan Zhang, Tao Liu, Xiao Li, Lei Zou

Geosciences Faculty Publications and Presentations

The rapid development of remote sensing techniques provides rich, large-coverage, and high-temporal information of the ground, which can be coupled with the emerging deep learning approaches that enable latent features and hidden geographical patterns to be extracted. This article marks the first attempt to cross-compare performances of popular state-of-the-art deep learning models in estimating population distribution from remote sensing images, investigate the contribution of neighboring effect, and explore the potential systematic population estimation biases. We conduct an end-to-end training of four popular deep learning architectures, i.e., VGG, ResNet, Xception, and DenseNet, by establishing a mapping between Sentinel-2 image patches and …

Impact Of Expanded Fda Indication For Icosapent Ethyl On Enhanced Cardiovascular Residual Risk Reduction, Seth Baum

All Publications

Hypertriglyceridemia is associated with increased cardiovascular disease (CVD) risk. The Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial (REDUCE-IT) demonstrated that the purified, stable ethyl ester of eicosapentaenoic acid, icosapent ethyl (IPE), added to statins reduced CVD events by 25% (p < 0.001), leading to an expanded indication in the USA. IPE is now approved as an adjunct to maximally tolerated statins to reduce CVD event risk in adults with triglyceride (TG) levels ≥150 mg/dl and either established CVD or diabetes mellitus plus ≥2 additional CVD risk factors. The new indication allows co-administration of IPE for elevated TG levels with statin treatment, enabling effective residual risk reduction in a broader at-risk population beyond what can be achieved with intensive low-density lipoprotein cholesterol control alone.

Keywords: cardiovascular disease; eicosapentaenoic acid; heart diseases; hypertriglyceridemia; icosapent ethyl; triglycerides.

A Comprehensive Study To Delineate The Role Of An Extracellular Vesicle-Associated Microrna-29a In Chronic Methamphetamine Use Disorder, Subhash Chand, Austin Gowen, Mason Savine, Dalia Moore, Alexander Clark, Wendy Huynh, Niming Wu, Katherine Odegaard, Lucas Weyrich, Rick A. Bevins, Howard S. Fox, Gurudutt Pendyala, Sowmya V. Yelamanchili

Journal Articles: Anesthesiology

Extracellular vesicles (EVs), which express a repertoire of cargo molecules (cf. proteins, microRNA, lipids, etc.), have been garnering a prominent role in the modulation of several cellular processes. Here, using both non-human primate and rodent model systems, we provide evidence that brain-derived EV (BDE) miRNA, miR-29a-3p (mir-29a), is significantly increased during chronic methamphetamine (MA) exposure. Further, miR-29a levels show significant increase both with drug-seeking and reinstatement in a rat MA self-administration model. We also show that EV-associated miR-29a is enriched in EV pool comprising of small EVs and exomeres and further plays a critical role in MA-induced inflammation and synaptodendritic …

Radi-11. Evaluating The Tissue Effects Of Dose-Escalated Pre-Operative Stereotactic Radiotherapy For Resectable Brain Metastasis, Rupesh Kotecha, Raees Tonse, Zuanel Diaz, Martin Tom, Matthew Hall, Minesh Mehta, Vitaly Siomin, Manmeet Ahluwalia

All Publications

No abstract provided.

Evaluation Of Somatic Mutations In Solid Metastatic Pan-Cancer Patients, Moom R. Roosan, Isa Mambetsariev, Rebecca Pharaon, Jeremy Fricke, Angel R. Baroz, Joseph Chao, Chen Chen, Mohd W. Nasser, Ramakanth C. Venkata, Maneesh Jain, Lynette M. Smith, Susan E. Yost, Karen L. Reckamp, Raju Pillai, Leonidas Arvanitis, Michelle Afkhami, Edward W. Wang, Vincent Chung, Mihaela Cristea, Marwan Fakih, Marianna Koczywas, Erminia Massarelli, Joanne Mortimer, Yuan Yuan, Surinder K. Batra, Sumanta Pal, Ravi Salgia

Journal Articles: Biochemistry & Molecular Biology

Metastasis continues to be the primary cause of all cancer-related deaths despite the recent advancements in cancer treatments. To evaluate the role of mutations in overall survival (OS) and treatment outcomes, we analyzed 957 metastatic patients with seven major cancer types who had available molecular testing results with a FoundationOne CDx^® panel. The most prevalent genes with somatic mutations were TP53, KRAS, APC, and LRP1B. In this analysis, these genes had mutation frequencies higher than in publicly available datasets. We identified that the somatic mutations were seven mutually exclusive gene pairs and an additional fifty-two co-occurring gene pairs. Mutations …

Repurposing Niclosamide For Targeting Pancreatic Cancer By Inhibiting Hh/Gli Non-Canonical Axis Of Gsk3Β, Jyoti B. Kaushal, Rakesh Bhatia, Ranjana K. Kanchan, Pratima Raut, Surya Mallapragada, Quan P. Ly, Surinder K. Batra, Satyanarayana Rachagani

Journal Articles: Biochemistry & Molecular Biology

Niclosamide (Nic), an FDA-approved anthelmintic drug, is reported to have anti-cancer efficacy and is being assessed in clinical trials for various solid tumors. Based on its ability to target multiple signaling pathways, in the present study, we evaluated the therapeutic efficacy of Nic on pancreatic cancer (PC) in vitro. We observed an anti-cancerous effect of this drug as shown by the G0/G1 phase cell cycle arrest, inhibition of PC cell viability, colony formation, and migration. Our results revealed the involvement of mitochondrial stress and mTORC1-dependent autophagy as the predominant players of Nic-induced PC cell death. Significant reduction of Nic-induced reactive …

Emerging Role Of Mir-345 And Its Effective Delivery As A Potential Therapeutic Candidate In Pancreatic Cancer And Other Cancers, Nagabhishek Sirpu Natesh, Brianna M. White, Maia M. C. White, Metin Uz, Rakhee Rathnam Kalari Kandy, Surinder K. Batra, Surya K. Mallapragada, Satyanarayana Rachagani

Journal Articles: Biochemistry & Molecular Biology

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with high mortality, poor prognosis, and palliative treatments, due to the rapid upregulation of alternative compensatory pathways and desmoplastic reaction. miRNAs, small non-coding RNAs, have been recently identified as key players regulating cancer pathogenesis. Dysregulated miRNAs are associated with molecular pathways involved in tumor development, metastasis, and chemoresistance in PDAC, as well as other cancers. Targeted treatment strategies that alter miRNA levels in cancers have promising potential as therapeutic interventions. miRNA-345 (miR-345) plays a critical role in tumor suppression and is differentially expressed in various cancers, including pancreatic cancer (PC). The underlying …

Disruption Of Fdps/Rac1 Axis Radiosensitizes Pancreatic Ductal Adenocarcinoma By Attenuating Dna Damage Response And Immunosuppressive Signalling, Parthasarathy Seshacharyulu, Sushanta Halder, Rama Krishna Nimmakayala, Satyanarayana Rachagani, Sanjib Chaudhary, Pranita Atri, Ramakanth C. Venkata, Michel M. Ouellette, Joseph Carmicheal, Shailendra K. Gautam, Raghupathy Vengoji, Shuo Wang, Sicong Li, Lynette M. Smith, Geoffrey A. Talmon, Kelsey Klute, Quan P. Ly, Bradley N. Reames, Jean L. Grem, Lyudmyla Berim, James C. Padussis, Sukhwinder Kaur, Sushil Kumar, Moorthy P. Ponnusamy, Maneesh Jain, Chi Lin, Surinder K. Batra

Journal Articles: Biochemistry & Molecular Biology

BACKGROUND: Radiation therapy (RT) has a suboptimal effect in patients with pancreatic ductal adenocarcinoma (PDAC) due to intrinsic and acquired radioresistance (RR). Comprehensive bioinformatics and microarray analysis revealed that cholesterol biosynthesis (CBS) is involved in the RR of PDAC. We now tested the inhibition of the CBS pathway enzyme, farnesyl diphosphate synthase (FDPS), by zoledronic acid (Zol) to enhance radiation and activate immune cells.

METHODS: We investigated the role of FDPS in PDAC RR using the following methods: in vitro cell-based assay, immunohistochemistry, immunofluorescence, immunoblot, cell-based cholesterol assay, RNA sequencing, tumouroids (KPC-murine and PDAC patient-derived), orthotopic models, and PDAC patient's …

Differential Gene Expression-Based Connectivity Mapping Identified Novel Drug Candidate And Improved Temozolomide Efficacy For Glioblastoma, Raghupathy Vengoji, Pranita Atri, Muzafar A. Macha, Parthasarathy Seshacharyulu, Naveenkumar Perumal, Kavita Mallya, Yutong Liu, Lynette M. Smith, Satyanarayana Rachagani, Sidharth Mahapatra, Moorthy P. Ponnusamy, Maneesh Jain, Surinder K. Batra, Nicole Shonka

Journal Articles: Biochemistry & Molecular Biology

BACKGROUND: Glioblastoma (GBM) has a devastating median survival of only one year. Treatment includes resection, radiation therapy, and temozolomide (TMZ); however, the latter increased median survival by only 2.5 months in the pivotal study. A desperate need remains to find an effective treatment.

METHODS: We used the Connectivity Map (CMap) bioinformatic tool to identify candidates for repurposing based on GBM's specific genetic profile. CMap identified histone deacetylase (HDAC) inhibitors as top candidates. In addition, Gene Expression Profiling Interactive Analysis (GEPIA) identified HDAC1 and HDAC2 as the most upregulated and HDAC11 as the most downregulated HDACs. We selected PCI-24781/abexinostat due to …

Arthroscopic Treatment Of Cystic Talus Osteochondral Lesions: Long-Term Results, Cary Chapman

All Publications

No abstract provided.