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2021

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Accountability’S Aa1000ap Standard: A Framework For Integrating Sustainability Into Organisations, Muhammad Bilal Farooq, Rashid Zaman, Muhammad Nadeem Jan 2021

Accountability’S Aa1000ap Standard: A Framework For Integrating Sustainability Into Organisations, Muhammad Bilal Farooq, Rashid Zaman, Muhammad Nadeem

Research outputs 2014 to 2021

Purpose: This study aims to evaluate corporate sustainability integration by evaluating corporate practices against the sustainability principles of inclusivity, materiality, responsiveness and impact outlined in AccountAbility’s AA1000 Accountability Principles (AA1000AP) standard.

Design/methodology/approach: Data comprise 12 semi-structured interviews with senior managers of listed New Zealand companies. Findings are evaluated against AccountAbility’s principles of inclusivity, materiality, responsiveness and impact, which are based on a normative view of stakeholder theory.

Findings: In terms of inclusivity, stakeholder engagement is primarily monologic and is directed more towards traditional stakeholder groups. However, social media, which is gaining popularity, has the potential to facilitate greater dialogic stakeholder …


Are National Cancer Control Indicators For Patient Experiences Being Met In Regional And Remote Australia? A Cross-Sectional Study Of Cancer Survivors Who Travelled For Treatment, Jeff Dunn, Belinda Goodwin, Joanne F. Aitken, Sonja March, Fiona Crawford-Williams, Michael Ireland, Nicholas Ralph, Leah Zajdlewicz, Arlen Rowe, Suzanne K. Chambers Jan 2021

Are National Cancer Control Indicators For Patient Experiences Being Met In Regional And Remote Australia? A Cross-Sectional Study Of Cancer Survivors Who Travelled For Treatment, Jeff Dunn, Belinda Goodwin, Joanne F. Aitken, Sonja March, Fiona Crawford-Williams, Michael Ireland, Nicholas Ralph, Leah Zajdlewicz, Arlen Rowe, Suzanne K. Chambers

Research outputs 2014 to 2021

Objective: To examine the health services experience of patients with cancer from regional and remote Australia using the Australian National Cancer Control Indicators (NCCI) guidelines as an assessment framework. Design: Cross-sectional. Setting Queensland non-for-profit cancer accommodation lodges. Participants: Participants were patients with cancer who travelled for treatment from rural and remote Queensland to major urban centres (n=518; age mean=64.6, SD=11.18). Outcome measures: Assessments included NCCI patient indicators, quality of life (QoL), psychological distress and unmet supportive care needs. Results: The frequency at which NCCI indicators were met ranged from 37.5% for receiving an assessment and care plan to 97.3% for …


The Role Of Sleep Curtailment On Leptin Levels In Obesity And Diabetes Mellitus, Maryam Mosavat, Mitra Mirsanjari, Diana Arabiat, Aisling Smyth, Lisa Whitehead Jan 2021

The Role Of Sleep Curtailment On Leptin Levels In Obesity And Diabetes Mellitus, Maryam Mosavat, Mitra Mirsanjari, Diana Arabiat, Aisling Smyth, Lisa Whitehead

Research outputs 2014 to 2021

Emerging evidence has identified sleep as a significant, but modifiable, risk factor for metabolic syndrome, diabetes, and obesity. Leptin, an adipocyte-derived peptide and a regulator of food intake and energy expenditure, has been shown to be associated with a short sleep duration in the pathophysiology of obesity and consequently type 2 diabetes. This review focuses on the current evidence indicating the effects of a short sleep duration on the regulation of leptin concentration in association with obesity and diabetes mellitus. In summary, the evidence suggests that sleep deprivation, by affecting leptin regulation, may lead to obesity and consequently development of …


How Is Organisational Fit Addressed In Australian Entry Level Midwifery Job Advertisements, Dianne Bloxsome, Courtney Glass, Sara Bayes Jan 2021

How Is Organisational Fit Addressed In Australian Entry Level Midwifery Job Advertisements, Dianne Bloxsome, Courtney Glass, Sara Bayes

Research outputs 2014 to 2021

Background: Midwifery job retention is an ongoing global issue. Prior research has recognised that considering an individual’s attributes in relation to their work environment may assist in improving job satisfaction among midwives, leading to improved long-term job retention in the midwifery profession. The aim of this study was to evaluate whether, and how organisational fit is addressed in current entry level midwifery job advertisements within Australia. Methods: Midwifery jobs were searched for within 12 search engines, using the search term ‘midwife’, including Seek.com, Indeed.com, government employment websites for all Australian states and territories, and private health organisation websites. Data were …


Process Development And Safety Evaluation Of Abcb5+ Limbal Stem Cells As Advanced-Therapy Medicinal Product To Treat Limbal Stem Cell Deficiency, Alexandra Norrick, Jasmina Esterlechner, Elke Niebergall-Roth, Ulf Dehio, Samar Sadeghi, Hannes M. Schröder, Seda Ballikaya, Nicole Stemler, Christoph Ganss, Kathrin Dieter, Ann-Kathrin Dachtler, Patrick Merz, Saadettin Sel, James Chodosh, Claus Cursiefen, Natasha Y. Frank, Gerd U. Auffarth, Bruce Ksander, Markus H. Frank, Mark A. Kluth Jan 2021

Process Development And Safety Evaluation Of Abcb5+ Limbal Stem Cells As Advanced-Therapy Medicinal Product To Treat Limbal Stem Cell Deficiency, Alexandra Norrick, Jasmina Esterlechner, Elke Niebergall-Roth, Ulf Dehio, Samar Sadeghi, Hannes M. Schröder, Seda Ballikaya, Nicole Stemler, Christoph Ganss, Kathrin Dieter, Ann-Kathrin Dachtler, Patrick Merz, Saadettin Sel, James Chodosh, Claus Cursiefen, Natasha Y. Frank, Gerd U. Auffarth, Bruce Ksander, Markus H. Frank, Mark A. Kluth

Research outputs 2014 to 2021

Background: While therapeutic success of the limbal tissue or cell transplantation to treat severe cases of limbal stem cell (LSC) deficiency (LSCD) strongly depends on the percentage of LSCs within the transplanted cells, prospective LSC enrichment has been hampered by the intranuclear localization of the previously reported LSC marker p63. The recent identification of the ATP-binding cassette transporter ABCB5 as a plasma membrane-spanning marker of LSCs that are capable of restoring the cornea and the development of an antibody directed against an extracellular loop of the ABCB5 molecule stimulated us to develop a novel treatment strategy based on the utilization …


An Integrative Literature Review Of The Implementation Of Microcredentials In Higher Education: Implications For Practice In Australasia, Ratna M. Selvaratnam, Michael D. Sankey Jan 2021

An Integrative Literature Review Of The Implementation Of Microcredentials In Higher Education: Implications For Practice In Australasia, Ratna M. Selvaratnam, Michael D. Sankey

Research outputs 2014 to 2021

Micro-credentials research, which includes digital badges, is a relatively new field of study that seeks to inform the implementation, portability and sustainability of the ecology of meaningful delivery. This paper reviews literature relevant to understanding connections between universities' intent to offer micro-credentials and the environment that is needed to do so. From this integrated study, the paper distils a number of core concerns and identifies some gaps in the literature. One of its primary goals is to clear the ground for the construction of a technical model of micro-credentialing implementation that can be used by the various stakeholders involved in …


Standardisation Of Clinical Assessment, Management And Follow-Up Of Acute Hospitalised Exacerbation Of Copd: A Europe-Wide Consensus, Sanjay Ramakrishnan, Wim Janssens, Pierre R. Burgel, Marco Contoli, Frits M. E. Franssen, Neil J. Greening, Timm Greulich, Iwein Gyselinck, Andreas Halner, Arturo Huerta, Rebecca L. Morgan, Jennifer K. Quint, Lowie E. G. W. Vanfleteren, Kristina Vermeersch, Henrik Watz, Mona Bafadhel Jan 2021

Standardisation Of Clinical Assessment, Management And Follow-Up Of Acute Hospitalised Exacerbation Of Copd: A Europe-Wide Consensus, Sanjay Ramakrishnan, Wim Janssens, Pierre R. Burgel, Marco Contoli, Frits M. E. Franssen, Neil J. Greening, Timm Greulich, Iwein Gyselinck, Andreas Halner, Arturo Huerta, Rebecca L. Morgan, Jennifer K. Quint, Lowie E. G. W. Vanfleteren, Kristina Vermeersch, Henrik Watz, Mona Bafadhel

Research outputs 2014 to 2021

Background: Despite hospitalization for exacerbation being a high-risk event for morbidity and mortality, there is little consensus globally regarding the assessment and management of hospitalised exacerbations of COPD. We aimed to establish a consensus list of symptoms, physiological measures, clinical scores, patient questionnaires and investigations to be obtained at time of hospitalised COPD exacerbation and follow-up. Methods: A modified Delphi online survey with pre-defined consensus of importance, feasibility and frequency of measures at hospitalisation and follow-up of a COPD exacerbation was undertaken. Findings: A total of 25 COPD experts from 18 countries contributed to all 3 rounds of the survey. …


Comparing An Ehealth Program (My Hip Journey) With Standard Care For Total Hip Arthroplasty: Randomized Controlled Trial, Rosemary Saunders, Karla Seaman, Laura Emery, Max Bulsara, Catherine Ashford, Judith Mcdowall, Karen Gullick, Beverley Ewens, Trudy Sullivan, Charlotte Foskett, Lisa Whitehead Jan 2021

Comparing An Ehealth Program (My Hip Journey) With Standard Care For Total Hip Arthroplasty: Randomized Controlled Trial, Rosemary Saunders, Karla Seaman, Laura Emery, Max Bulsara, Catherine Ashford, Judith Mcdowall, Karen Gullick, Beverley Ewens, Trudy Sullivan, Charlotte Foskett, Lisa Whitehead

Research outputs 2014 to 2021

Background: The role of eHealth programs to support patients through surgical pathways, including total hip arthroplasty (THA), is rapidly growing and offers the potential to improve patient engagement, self-care, and outcomes. Objective: The aim of this study is to compare the effects of an eHealth program (intervention) versus standard care for pre- and postoperative education on patient outcomes for primary THA. Methods: A prospective parallel randomized controlled trial with two arms (standard care and standard care plus access to the eHealth education program) was conducted. Participants included those who underwent THA. Outcome measures were collected preadmission, at 6 weeks, and …


Development Of A Breech-Specific Integrated Care Pathway For Pregnant Women: Protocol For A Mixed Methods Study, Sara Morris, Sadie Geraghty, Deborah Sundin Jan 2021

Development Of A Breech-Specific Integrated Care Pathway For Pregnant Women: Protocol For A Mixed Methods Study, Sara Morris, Sadie Geraghty, Deborah Sundin

Research outputs 2014 to 2021

Background: The development of an integrated care pathway with multidisciplinary input to standardize and streamline care for pregnant women experiencing breech presentation at 36 or more weeks of gestation poses several challenges because of the divisive and contentious nature of the phenomenon. Although many clinicians are interested in obtaining the skills required to safely support women desiring a vaginal breech birth, the primary trend in most health care facilities is to recommend a cesarean section. Objective: This paper aims to discuss the mixed methods approach used in a doctoral study conducted to generate new knowledge regarding women’s experiences of breech …


Early Detection Of Ultra High Risk For Psychosis In A Norwegian Catchment Area: The Two Year Follow-Up Of The Prevention Of Psychosis Study, Inge Joa, Jone Bjornestad, Jan O. Johannessen, Johannes Langeveld, Helen J. Stain, Melissa Weibell, Wenche T. V. Hegelstad Jan 2021

Early Detection Of Ultra High Risk For Psychosis In A Norwegian Catchment Area: The Two Year Follow-Up Of The Prevention Of Psychosis Study, Inge Joa, Jone Bjornestad, Jan O. Johannessen, Johannes Langeveld, Helen J. Stain, Melissa Weibell, Wenche T. V. Hegelstad

Research outputs 2014 to 2021

Objectives: Most individuals experience a relatively long period of sub-clinical psychotic like symptoms, known as the ultra high risk (UHR) or at risk mental states (ARMS), prior to a first episode of psychosis. Approximately 95% of individuals who will later develop psychosis are not referred to specialized clinical services and assessed during the UHR phase. The study aimed to investigate whether a systematic early detection program, modeled after the successful early detection of psychosis program TIPS, would improve the detection of help-seeking UHR individuals. The secondary aim was to examine the rates and predictors of conversion to psychosis after 2 …


Detect Schools Study Protocol: A Prospective Observational Cohort Surveillance Study Investigating The Impact Of Covid-19 In Western Australian Schools, Marianne J. Mullane, Hannah M. Thomas, Melanie Epstein, Joelie Mandzufas, Narelle Mullan, Alexandra Whelan, Karen Lombardi, Tina Barrow, Sherlynn Ang, Adele Leahy, Ewan Cameron, Leanne Lester, Matt Cooper, Paul Stevenson, Mitch Hartman, Anne Mckenzie, Francis Mitrou, Stephen R. Zubrick, Juli Coffin, Donna Cross, Asha C. Bowen, Peter Gething Jan 2021

Detect Schools Study Protocol: A Prospective Observational Cohort Surveillance Study Investigating The Impact Of Covid-19 In Western Australian Schools, Marianne J. Mullane, Hannah M. Thomas, Melanie Epstein, Joelie Mandzufas, Narelle Mullan, Alexandra Whelan, Karen Lombardi, Tina Barrow, Sherlynn Ang, Adele Leahy, Ewan Cameron, Leanne Lester, Matt Cooper, Paul Stevenson, Mitch Hartman, Anne Mckenzie, Francis Mitrou, Stephen R. Zubrick, Juli Coffin, Donna Cross, Asha C. Bowen, Peter Gething

Research outputs 2014 to 2021

Introduction: Amidst the evolving COVID-19 pandemic, understanding the transmission dynamics of the SARS-CoV-2 virus is key to providing peace of mind for the community and informing policy-making decisions. While available data suggest that school-aged children are not significant spreaders of SARS-CoV-2, the possibility of transmission in schools remains an ongoing concern, especially among an aging teaching workforce. Even in low-prevalence settings, communities must balance the potential risk of transmission with the need for students' ongoing education. Through the roll out of high-throughput school-based SARS-CoV-2 testing, enhanced follow-up for individuals exposed to COVID-19 and wellbeing surveys, this study investigates the dynamics …


Plasma Amyloid‐Beta Levels In A Pre‐Symptomatic Dutch‐Type Hereditary Cerebral Amyloid Angiopathy Pedigree: A Cross‐Sectional And Longitudinal Investigation, Pratishtha Chatterjee, Michelle Tegg, Steve Pedrini, Anne M. Fagan, Chengjie Xiong, Abhay K. Singh, Kevin Taddei, Samantha Gardener, Colin L. Masters, Peter R. Schofield, Gerhard Multhaup, Tammie L. S. Benzinger, John C. Morris, Randall J. Bateman, Steven M. Greenberg, Mark A. Van Buchem, Erik Stoops, Hugo Vanderstichele, Charlotte E. Teunissen, Graeme J. Hankey, Marieke J. H. Wermer, Hamid R. Sohrabi, Ralph N. Martins, The Dominantly Inherited Alzheimer Network Jan 2021

Plasma Amyloid‐Beta Levels In A Pre‐Symptomatic Dutch‐Type Hereditary Cerebral Amyloid Angiopathy Pedigree: A Cross‐Sectional And Longitudinal Investigation, Pratishtha Chatterjee, Michelle Tegg, Steve Pedrini, Anne M. Fagan, Chengjie Xiong, Abhay K. Singh, Kevin Taddei, Samantha Gardener, Colin L. Masters, Peter R. Schofield, Gerhard Multhaup, Tammie L. S. Benzinger, John C. Morris, Randall J. Bateman, Steven M. Greenberg, Mark A. Van Buchem, Erik Stoops, Hugo Vanderstichele, Charlotte E. Teunissen, Graeme J. Hankey, Marieke J. H. Wermer, Hamid R. Sohrabi, Ralph N. Martins, The Dominantly Inherited Alzheimer Network

Research outputs 2014 to 2021

Plasma amyloid‐beta (Aβ) has long been investigated as a blood biomarker candidate for Cerebral Amyloid Angiopathy (CAA), however previous findings have been inconsistent which could be attributed to the use of less sensitive assays. This study investigates plasma Aβ alterations between pre‐symptomatic Dutch‐type hereditary CAA (D‐CAA) mutation‐carriers (MC) and non-carriers (NC) using two Aβ measurement platforms. Seventeen pre‐symptomatic members of a D‐ CAA pedigree were assembled and followed up 3–4 years later (NC = 8;MC = 9). Plasma Aβ1‐40 and Aβ1‐42 were cross‐sectionally and longitudinally analysed at baseline (T1) and follow‐up (T2) and were found to be lower in MCs …


Metabolomics And Lipidomics: Expanding The Molecular Landscape Of Exercise Biology, Mehdi R. Belhaj, Nathan G. Lawler, Nolan J. Hoffman Jan 2021

Metabolomics And Lipidomics: Expanding The Molecular Landscape Of Exercise Biology, Mehdi R. Belhaj, Nathan G. Lawler, Nolan J. Hoffman

Research outputs 2014 to 2021

Dynamic changes in circulating and tissue metabolites and lipids occur in response to exercise-induced cellular and whole-body energy demands to maintain metabolic homeostasis. The metabolome and lipidome in a given biological system provides a molecular snapshot of these rapid and complex metabolic perturbations. The application of metabolomics and lipidomics to map the metabolic responses to an acute bout of aerobic/endurance or resistance exercise has dramatically expanded over the past decade thanks to major analytical advancements, with most exercise-related studies to date focused on analyzing human biofluids and tissues. Experimental and analytical con-siderations, as well as complementary studies using animal model …


Exploring The Usability Of The Com-B Model And Theoretical Domains Framework (Tdf) To Define The Helpers Of And Hindrances To Evidence-Based Practice In Midwifery, Annemarie De Leo, Sara J. Bayes, Dianne Bloxsome, Janice Butt Jan 2021

Exploring The Usability Of The Com-B Model And Theoretical Domains Framework (Tdf) To Define The Helpers Of And Hindrances To Evidence-Based Practice In Midwifery, Annemarie De Leo, Sara J. Bayes, Dianne Bloxsome, Janice Butt

Research outputs 2014 to 2021

Background Despite the advancement of scientific research in the field of maternity care, midwives face challenges translating latest evidence into evidence-based practice (EBP) and express reticence towards leading practice change in clinical areas. This study aimed to explore midwifery leaders’ views on what factors help or hinder midwives’ efforts to translate latest evidence into everyday practice and consider them in relation to both the Capability, Opportunity, Motivation and Behaviour (COM-B) model and Theoretical Domains Framework (TDF). Methods This qualitative study formed part of a larger action research (AR) project that was designed to improve midwives’ EBP implementation capability. Data were …


High Commitment Hrm And Burnout Of Frontline Food Service Employees: A Moderated Mediation Model, Stephen T. Teo, Diep T. N. Nguyen, Azadeh Shafaei, Tim Bentley Jan 2021

High Commitment Hrm And Burnout Of Frontline Food Service Employees: A Moderated Mediation Model, Stephen T. Teo, Diep T. N. Nguyen, Azadeh Shafaei, Tim Bentley

Research outputs 2014 to 2021

Purpose:

Drawing from the Job Demands-Resources (JD-R) framework and Conservation of Resources (COR) theory, the authors’ study examines the impact of high commitment HR management (HCHRM) practices and psychological capital (PsyCap) on job autonomy and job demands in predicting burnout in frontline food service employees.

Design/methodology/approach:

A moderated mediation model was developed and tested on 257 Australian workers employed in the food service industry. Hypotheses were tested using structural equation modeling.

Findings:

There was support for the mediation effect of HCHRM on burnout, via two sequential mediators: job autonomy and job demands. PsyCap was found to buffer (moderation) the effect …


Developing And Validating A Chinese Cultural Value Scale In Tourism, Songshan (Sam) Huang, Jun Wen Jan 2021

Developing And Validating A Chinese Cultural Value Scale In Tourism, Songshan (Sam) Huang, Jun Wen

Research outputs 2014 to 2021

Chinese cultural values are important in understanding Chinese tourists’ behaviour. However, the literature is void of a relevant scale measuring Chinese cultural values in tourism. This research aims to develop and validate a Chinese cultural values scale in tourism (abbreviated as CCV-T). Following a rigorous scale development procedure and applying multi-stage studies, the research identified a 5-factor measurement scale of CCV-T, composed of 17 items with sufficient reliability and validity. The five Chinese cultural value factors are Leisure and Life Enjoyment (LLE), Filial Piety and Relationship (FPR), Self-fulfilment, Righteousness, and Humanity. The CCV-T scale provides a …


Association Of Genetic Variants With Prostate Cancer In Africa: A Concise Review, Emmanuel Acheampong, Evans A. Adu, Christian Obirikorang, George Amoah, Osei O. Afriyie, Joseph Yorke, Enoch O. Anto, Michael A. Gyamfi, Emmanuella N. Acheampong, Christian K. Gyasi-Sarpong, Francis A. Yeboah Jan 2021

Association Of Genetic Variants With Prostate Cancer In Africa: A Concise Review, Emmanuel Acheampong, Evans A. Adu, Christian Obirikorang, George Amoah, Osei O. Afriyie, Joseph Yorke, Enoch O. Anto, Michael A. Gyamfi, Emmanuella N. Acheampong, Christian K. Gyasi-Sarpong, Francis A. Yeboah

Research outputs 2014 to 2021

Background: Prostate cancer (PCa) has one of the highest heritability of all major cancers, where the genetic contribution has been documented, and knowledge about the molecular genetics of the disease is increasing. However, the extent and aspects to which genetic variants explain PCa heritability in Africa are limited. Main body: In this review, we summarize studies that highlight how identified genetic variants explain differences in PCa incidence and presentation across ethnic groups. We also present the knowledge gaps in PCa genetics in Africa and why Africa represents an untapped potential ground for genetic studies on PCa. A significant number of …


Circulating Tumor Dna Reflects Uveal Melanoma Responses To Protein Kinase C Inhibition, John J. Park, Russell J. Diefenbach, Natalie Byrne, Georgina V. Long, Richard A. Scolyer, Elin S. Gray, Matteo S. Carlino, Helen Rizos Jan 2021

Circulating Tumor Dna Reflects Uveal Melanoma Responses To Protein Kinase C Inhibition, John J. Park, Russell J. Diefenbach, Natalie Byrne, Georgina V. Long, Richard A. Scolyer, Elin S. Gray, Matteo S. Carlino, Helen Rizos

Research outputs 2014 to 2021

The prognosis for patients with UM is poor, and recent clinical trials have failed to prolong overall survival (OS) of these patients. Over 95% of UM harbor activating driver mutations, and this allows for the investigation of ctDNA. In this study, we investigated the value of ctDNA for adaptive clinical trial design in metastatic UM. Longitudinal plasma samples were analyzed for ctDNA in 17 metastatic UM patients treated with PKCi-based therapy in a phase 1 clinical trial setting. Plasma ctDNA was assessed using digital droplet PCR (ddPCR) and a custom melanoma gene panel for targeted next generation sequencing (NGS). Baseline …


Classification Of Skin Disease Using Deep Learning Neural Networks With Mobilenet V2 And Lstm, Parvathaneni N. Srinivasu, Jalluri G. Siva Sai, Muhammad F. Ijaz, Akash K. Bhoi, Wonjoon Kim, James J. Kang Jan 2021

Classification Of Skin Disease Using Deep Learning Neural Networks With Mobilenet V2 And Lstm, Parvathaneni N. Srinivasu, Jalluri G. Siva Sai, Muhammad F. Ijaz, Akash K. Bhoi, Wonjoon Kim, James J. Kang

Research outputs 2014 to 2021

Deep learning models are efficient in learning the features that assist in understanding complex patterns precisely. This study proposed a computerized process of classifying skin disease through deep learning-based MobileNet V2 and Long Short Term Memory (LSTM). The MobileNet V2 model proved to be efficient with a better accuracy that can work on lightweight computational devices. The proposed model is efficient in maintaining stateful information for precise predictions. A grey-level co-occurrence matrix is used for assessing the progress of diseased growth. The performance has been compared against other state-of-the-art models such as Fine-Tuned Neural Networks (FTNN), Convolutional Neural Network (CNN), …


Functional Maturation Of Immature Β Cells: A Roadblock For Stem Cell Therapy For Type 1 Diabetes, Zi-Yi Sun, Ting-Yan Yu, Fang-Xu Jiang, Wei Wang Jan 2021

Functional Maturation Of Immature Β Cells: A Roadblock For Stem Cell Therapy For Type 1 Diabetes, Zi-Yi Sun, Ting-Yan Yu, Fang-Xu Jiang, Wei Wang

Research outputs 2014 to 2021

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease caused by the specific destruction of pancreatic islet β cells and is characterized as the absolute insufficiency of insulin secretion. Current insulin replacement therapy supplies insulin in a non-physiological way and is associated with devastating complications. Experimental islet transplantation therapy has been proven to restore glucose homeostasis in people with severe T1DM. However, it is restricted by many factors such as severe shortage of donor sources, progressive loss of donor cells, high cost, etc. As pluripotent stem cells have the potential to give rise to all cells including islet β …


A Survey Of Western Australian Teachers’ Use Of Texts In Supporting Beginning Readers, Simmone Pogorzelski, Susan Main, Susan Hill Jan 2021

A Survey Of Western Australian Teachers’ Use Of Texts In Supporting Beginning Readers, Simmone Pogorzelski, Susan Main, Susan Hill

Research outputs 2014 to 2021

Connected text reading is crucial to beginning reading development as this is where children apply the reading skills they are learning. The most recent version of the Australian Curriculum includes the requirement that teachers use both predictable and decodable texts in early reading instruction. As each text type is underpinned by a different approach to reading instruction, this creates a potential dilemma for teachers when implementing the curriculum. A preliminary study of the instructional practices used to teach reading in the first two years of schooling was therefore conducted to investigate how early years teachers make use of two different …


Prevalence Of Distress, Its Associated Factors And Referral To Support Services In People With Cancer, Deborah Kirk, Istvan (Ishti) Kabdebo, Lisa Whitehead Jan 2021

Prevalence Of Distress, Its Associated Factors And Referral To Support Services In People With Cancer, Deborah Kirk, Istvan (Ishti) Kabdebo, Lisa Whitehead

Research outputs 2014 to 2021

Aims and objectives:

To (i) characterise prevalence of distress amongst people diagnosed with cancer, (ii) determine factors associated with increasing distress, (iii) describe reported problems for those with clinically significant distress and (iv) investigate the factors associated with referral to support services.

Background:

International studies report a high prevalence of clinically significant distress in people with cancer. Australian studies are notably lacking. Additionally, clinicians still do not fully understand the factors associated with cancer-related distress.

Design:

Period prevalence study.

Methods:

Distress screening data were analysed for 1,071 people accessing the Cancer Council Western Australia information and support line between 01/01/2016–31/12/2018. …


Vegetable Nitrate Intake, Blood Pressure And Incident Cardiovascular Disease: Danish Diet, Cancer, And Health Study, Catherine P. Bondonno, Frederik Dalgaard, Lauren C. Blekkenhorst, Kevin Murray, Joshua R. Lewis, Kevin D. Croft, Cecilie Kyrø, Christian Torp-Pedersen, Gunnar Gislason, Anne Tjønneland, Kim Overvad, Nicola P. Bondonno, Jonathan M. Hodgson Jan 2021

Vegetable Nitrate Intake, Blood Pressure And Incident Cardiovascular Disease: Danish Diet, Cancer, And Health Study, Catherine P. Bondonno, Frederik Dalgaard, Lauren C. Blekkenhorst, Kevin Murray, Joshua R. Lewis, Kevin D. Croft, Cecilie Kyrø, Christian Torp-Pedersen, Gunnar Gislason, Anne Tjønneland, Kim Overvad, Nicola P. Bondonno, Jonathan M. Hodgson

Research outputs 2014 to 2021

Whether the vascular effects of inorganic nitrate, observed in clinical trials, translate to a reduction in cardiovascular disease (CVD) with habitual dietary nitrate intake in prospective studies warrants investigation. We aimed to determine if vegetable nitrate, the major dietary nitrate source, is associated with lower blood pressure (BP) and lower risk of incident CVD. Among 53,150 participants of the Danish Diet, Cancer, and Health Study, without CVD at baseline, vegetable nitrate intake was assessed using a comprehensive vegetable nitrate database. Hazard ratios (HRs) were calculated using restricted cubic splines based on multivariable-adjusted Cox proportional hazards models. During 23 years of …


Habitual Flavonoid Intake And Ischemic Stroke Incidence In The Danish Diet, Cancer, And Health Cohort, Benjamin H. Parmenter, Frederik Dalgaard, Kevin Murray, Aedin Cassidy, Catherine P. Bondonno, Joshua R. Lewis, Kevin D. Croft, Cecilie Kyrø, Gunnar Gislason, Augustin Scalbert, Anne Tjønneland, Jonathan M. Hodgson, Nicola P. Bondonno Jan 2021

Habitual Flavonoid Intake And Ischemic Stroke Incidence In The Danish Diet, Cancer, And Health Cohort, Benjamin H. Parmenter, Frederik Dalgaard, Kevin Murray, Aedin Cassidy, Catherine P. Bondonno, Joshua R. Lewis, Kevin D. Croft, Cecilie Kyrø, Gunnar Gislason, Augustin Scalbert, Anne Tjønneland, Jonathan M. Hodgson, Nicola P. Bondonno

Research outputs 2014 to 2021

Background

Flavonoid-rich foods have antiinflammatory, antiatherogenic, and antithrombotic properties that may contribute to a lower risk of ischemic stroke.

Objectives

We aimed to investigate the relationship between habitual flavonoid consumption and incidence of ischemic stroke in participants from the Danish Diet, Cancer and Health Study.

Design

In this prospective cohort study, 55,169 Danish residents without a prior ischemic stroke [median (IQR) age at enrolment of 56 y (52–60)], were followed for 21 y (20–22). We used Phenol-Explorer to estimate flavonoid intake from food frequency questionnaires obtained at study entry. Incident cases of ischemic stroke were identified from Danish nationwide registries …


Validation Of Fatty Liver Disease Scoring Systems For Ultrasound Diagnosed Non-Alcoholic Fatty Liver Disease In Adolescents, Fuzhen Wan, Feng Pan, Oyekoya T. Ayonrinde, Leon A. Adams, Trevor A. Mori, Lawrence J. Beilin, Therese A. O'Sullivan, John K. Olynyk, Wendy H. Oddy Jan 2021

Validation Of Fatty Liver Disease Scoring Systems For Ultrasound Diagnosed Non-Alcoholic Fatty Liver Disease In Adolescents, Fuzhen Wan, Feng Pan, Oyekoya T. Ayonrinde, Leon A. Adams, Trevor A. Mori, Lawrence J. Beilin, Therese A. O'Sullivan, John K. Olynyk, Wendy H. Oddy

Research outputs 2014 to 2021

Background and Aims: The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing in young populations. However, there are inadequate data regarding diagnosis of NAFLD. We aimed to validate three scoring systems against a previous standard of suprailiac skinfold thickness for diagnosing NAFLD in population-based adolescents.

Methods: Seventeen-year-old adolescents (n = 899), participating in the Raine Study, attended a cross-sectional follow-up. NAFLD was diagnosed using liver ultrasound. Scores for Fatty liver index (FLI), Hepatic Steatosis Index (HSI) and Zhejiang University index (ZJU index) were calculated. Diagnostic accuracy of these diagnostic tests was evaluated through discrimination and calibration.

Results: NAFLD …


Educational Outcomes Of Adolescents Participating In Specialist Sport Programs In Low Ses Areas Of Western Australia: A Mixed Methods Study, Eibhlish O'Hara, Craig Harms, Fadi Ma'ayah, Craig Speelman Jan 2021

Educational Outcomes Of Adolescents Participating In Specialist Sport Programs In Low Ses Areas Of Western Australia: A Mixed Methods Study, Eibhlish O'Hara, Craig Harms, Fadi Ma'ayah, Craig Speelman

Research outputs 2014 to 2021

Specialist Sport Programs (SSPs) are an underexamined activity that combines the best features of two different contexts for adolescent development: a sporting program and a secondary school. A mixed-methods study was conducted to determine the influence of participation in SSPs on the educational outcomes of lower secondary students in Western Australia. The results demonstrated a significant improvement in specialist students' mean grade for Mathematics over the course of a year, while their mean grade for all other subjects, and their level of engagement with school, remained stable over the same period of time. Semi-structured interviews were also conducted with key …


A Novel Augmented Deep Transfer Learning For Classification Of Covid-19 And Other Thoracic Diseases From X-Rays, Fouzia Atlaf, Syed M. S. Islam, Naeem K. Janjua Jan 2021

A Novel Augmented Deep Transfer Learning For Classification Of Covid-19 And Other Thoracic Diseases From X-Rays, Fouzia Atlaf, Syed M. S. Islam, Naeem K. Janjua

Research outputs 2014 to 2021

Deep learning has provided numerous breakthroughs in natural imaging tasks. However, its successful application to medical images is severely handicapped with the limited amount of annotated training data. Transfer learning is commonly adopted for the medical imaging tasks. However, a large covariant shift between the source domain of natural images and target domain of medical images results in poor transfer learning. Moreover, scarcity of annotated data for the medical imaging tasks causes further problems for effective transfer learning. To address these problems, we develop an augmented ensemble transfer learning technique that leads to significant performance gain over the conventional transfer …


Digital Forensic Readiness Intelligence Crime Repository, Victor R. Kebande, Nickson M. Karie, Kim-Kwang R. Choo, Sadi Alawadi Jan 2021

Digital Forensic Readiness Intelligence Crime Repository, Victor R. Kebande, Nickson M. Karie, Kim-Kwang R. Choo, Sadi Alawadi

Research outputs 2014 to 2021

It may not always be possible to conduct a digital (forensic) investigation post-event if there is no process in place to preserve potential digital evidence. This study posits the importance of digital forensic readiness, or forensic-by-design, and presents an approach that can be used to construct a Digital Forensic Readiness Intelligence Repository (DFRIR). Based on the concept of knowledge sharing, the authors leverage this premise to suggest an intelligence repository. Such a repository can be used to cross-reference potential digital evidence (PDE) sources that may help digital investigators during the process. This approach employs a technique of capturing PDE from …


Shyness, Self-Esteem, And Loneliness As Causes Of Fa: The Moderating Effect Of Low Self-Control, Mohammad Iranmanesh, Behzad Foroughi, Davoud Nikbin, Sunghyup Sean Hyun Jan 2021

Shyness, Self-Esteem, And Loneliness As Causes Of Fa: The Moderating Effect Of Low Self-Control, Mohammad Iranmanesh, Behzad Foroughi, Davoud Nikbin, Sunghyup Sean Hyun

Research outputs 2014 to 2021

This study examined the impacts of shyness, self-esteem and loneliness on Facebook addiction by considering their inter-relations. Furthermore, the moderating effect of low self-control on the relationship between Facebook addiction and individuals’ performance was also examined. Data were collected via an online survey from 348 Malaysians and were analysed using the partial least squares technique. The results showed that shyness has both a direct effect and an indirect effect through loneliness on Facebook addiction. Although self-esteem has no direct effect on Facebook addiction, it has an indirect effect through loneliness. The results also confirmed that low self-control negatively moderates the …


Development And Validation Of A Scale To Explore Pre-Service Teachers’ Sense Of Preparedness, Engagement And Self-Efficacy In Classroom Teaching, Jessy Abraham, Tania Ferfolja, Aaron Sickel, Anne Power, Christina Curry, Denise Fraser, Karin Mackay Jan 2021

Development And Validation Of A Scale To Explore Pre-Service Teachers’ Sense Of Preparedness, Engagement And Self-Efficacy In Classroom Teaching, Jessy Abraham, Tania Ferfolja, Aaron Sickel, Anne Power, Christina Curry, Denise Fraser, Karin Mackay

Australian Journal of Teacher Education

Raising the quality of initial teacher education can make an important contribution to raising the overall quality of the school system. In Australia, the National Framework for Professional Standards for Teaching is used as a common framework to set standards for the accreditation of teacher education programs. However, institution-wise assessments need to be carried out regularly to explore the quality of preparation pre-service teachers receive and to what extent they feel well prepared to enter teaching. This will enable teacher education programs to implement strategies to strengthen the link between university coursework and professional practice of pre service teachers. This …