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2021

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การเลือกใช้เทคนิคพยากรณ์สำหรับสินค้าประเภทเวชภัณฑ์, อธิเมศร์ เชาว์สุทธิศักดิ์ Jan 2021

การเลือกใช้เทคนิคพยากรณ์สำหรับสินค้าประเภทเวชภัณฑ์, อธิเมศร์ เชาว์สุทธิศักดิ์

Chulalongkorn University Theses and Dissertations (Chula ETD)

งานวิจัยเรื่องการเลือกใช้เทคนิคพยากรณ์สำหรับสินค้าประเภทเวชภัณฑ์ จากการวิเคราะห์ตัวอย่าง บริษัทตัวอย่าง A ซึ่งเป็นบริษัทนำเข้าสินค้าและจัดจำหน่ายเวชภัณฑ์และผลิตภัณฑ์เพื่อสุขภาพ ปัจจุบันกำลังประสบปัญหาสินค้ามีอายุสั้น อันเนื่องมาจากปริมาณการสั่งซื้อสินค้ามีมากกว่าปริมาณที่สามารถขายออกไปได้ ปัญหาเหล่านี้มีสาเหตุมาจากการขาดความแม่นยำในการการวางแผนการขายสินค้า และการสำรองเวชภัณฑ์ที่มากกว่าความต้องการใช้จริง จากการศึกษาข้อมูลเบื้องต้น ด้วยการจัดการวัตถุดิบคงคลังพบว่า ในส่วนที่ 1จำแนกประเภทโดยใช้ด้วยวิธี ABC Classification ตามหลักเกณฑ์เรื่องอายุการเก็บรักษา สินค้ากลุ่ม A มีสินค้าทั้งหมด 12 รายการ โดยมีอายุการเก็บรักษาที่ 1 ปี โดยมีปริมาณการขายเฉลี่ย 3 ปีทั้งสิ้นจำนวน 45,339 ขวด และมีมูลค่าการขายเฉลี่ย 3 ปีทั้งสิ้นจำนวน 47,673,060 บาท โดยคิดเป็นสัดส่วนร้อยละ 34.27 ของมูลค่าสินค้าทั้งหมด ในส่วนที่ 2 การพยากรณ์ความต้องการ จากการคำณวนโดยใช้วิธีการพยากรณ์ทั้ง 7 วิธีกับ 12 รายการ ผู้วิจัยพบว่า แต่ละรายการสามารถใช้วิธีการพยากรณ์ที่เหมาะสมที่สุดแตกต่างกันออกไป ตัวอย่างเช่น วิธีการพยากรณ์ DECOMPOSITION METHOD เป็นวิธีที่ให้ค่าความคลาดเคลื่อนน้อยที่สุดโดยใช้ค่า MAD, MSE และ MAPE สำหรับรายการ ARIXTRA PFS 2.5MG./0.5 ML. 1X10เป็นวิธีที่เหมาะสมที่สุด ส่วนที่ 3 ต้นทุนรวมสินค้าคงคลังที่ต่ำที่สุดโดยรวมของกลุ่ม A ใน 2 แบบ พบว่ารูปแบบการจัดซื้อแบบปัจจุบันคือ 45,375,531 บาทต่อปี และรูปแบบการจัดซื้อแบบ EOQ คือ 33,545,039 บาทต่อปี มีค่ามากกว่าต้นทุนรวมสินค้าคงคลังที่ต่ำที่สุดโดยรวมในแบบ EOQ อยู่ที่ 11,830,492 บาท


The Garden Oasis: Observations In A Southern California Garden, Chris Tankersley Jan 2021

The Garden Oasis: Observations In A Southern California Garden, Chris Tankersley

Department of Entomology: Distance Master of Science Projects

A garden can be a special place of relaxation and a corridor from which one can connect with the natural world and observe the complex relationships among the many organisms that make it their home. These organisms include a vast array of insects that contribute to the diversity of even the smallest garden. We purchased an unassuming house in a quiet Southern California suburban neighborhood that included about half an acre of property made up of mostly lawn and a dense menagerie of backyard shrubs and trees on a steep hillside, along with a pond that was in desperate need …


Overview Of The Insect Food And Feed Industry, Daniel J. Seckman Jan 2021

Overview Of The Insect Food And Feed Industry, Daniel J. Seckman

Department of Entomology: Distance Master of Science Projects

The entomophagy field is one that when you immerse yourself in it, you will feel like the entire world is talking about insects as food and feed. Yet, from the outside, the industry is virtually nonexistent. In the United States, the North American Coalition for Insect Agriculture (NACIA) is the leading organization dedicated to growing the insect food and feed sector. While the organization has grown extensively in recent years, most individuals in the food, feed, and entomological industry have never heard of the organization. The Wall Street Journal presents the annual Food Forum, which aims to “tackle the critical …


Distribution Of Green Spaces In Omaha, Nebraska, Sofia Gavia Jan 2021

Distribution Of Green Spaces In Omaha, Nebraska, Sofia Gavia

Department of Environmental Studies: Undergraduate Student Theses

The distribution of parks often depends on the races, ethnicity, and socioeconomic class of a community’s households. Parks and green spaces provides community residents recreational opportunities, economic benefits, and improves community public health. The unequal distribution of parks and green spaces in a city is a social issue found across the country. Limited research has been done on the relationship between green spaces and park access and social justice in Omaha, Nebraska. This study discusses whether there is a difference in how parks are distributed in Omaha, NE in terms of social justice and equitable distribution. Research is done using …


Analysis Of Drinking Water Disinfection Options, Bryce Carlen Jan 2021

Analysis Of Drinking Water Disinfection Options, Bryce Carlen

Department of Environmental Studies: Undergraduate Student Theses

This thesis utilizes existing research to provide a framework that can be used for community and disaster planning. It analyses the critical process of water disinfection for drinking water. It focuses on chemical, distillation, and ultraviolet treatments in both centralized and point-of-use treatment. This thesis aims to provide a method for communities to determine the optimal water treatment, utilizing a framework based on weighted criteria. The decision-making framework is an easy-to-use and flexible process that communities can tailor for their specific needs to find the optimal treatment relative to their needs. In this study’s generalized example, ultraviolet treatment and distillation …


Audit Of Waste Collected Over One Week From Superior Dental Health Of Lincoln, Bryclin Alstrom Jan 2021

Audit Of Waste Collected Over One Week From Superior Dental Health Of Lincoln, Bryclin Alstrom

Department of Environmental Studies: Undergraduate Student Theses

A waste audit of Superior Dental Health of Lincoln was conducted in order to propagate the implementation of sustainable waste management practices within the company. Differentiating between hazardous waste and solid waste is necessary for environmentally friendly waste management and ceasing the spread of infectious pathogens. The audit identified nine different materials contributing to the biomedical waste stream of the company. Of which, personal protective equipment (PPE) is of major concern due to the financial commitment necessary to acquire / dispose of these products, as well as the strain in supply due to the current COVID-19 pandemic. The results of …


Long-Term Impacts Of 2019 Flood Experiences On Nebraskans’ Climate Change Perceptions, Caitlin Kingsley Jan 2021

Long-Term Impacts Of 2019 Flood Experiences On Nebraskans’ Climate Change Perceptions, Caitlin Kingsley

Department of Environmental Studies: Undergraduate Student Theses

This study examines climate change perceptions in Nebraskans who experienced or witnessed flooding in March 2019. The purpose is to determine the impacts of 2019 flood experiences on Nebraskans’ climate change perceptions. The objectives are to determine the influence of flood proximity on changes in climate change perceptions, determine whether 2019 flooding had long-term impacts on Nebraskans’ climate change perceptions, and determine the influence of personal background factors on perceptions. A three-phase interview was utilized to collect background information, climate change perceptions, 2019 flood experiences, and relationships between 2019 flood experiences and climate change perceptions. Background information and climate change …


The Effect Of Urban Forests On Air Quality And Human Health, Chance Wilken Jan 2021

The Effect Of Urban Forests On Air Quality And Human Health, Chance Wilken

Department of Environmental Studies: Undergraduate Student Theses

Following the industrial revolution, the impacts of climate change have been increasingly impactful on both rural and urban populations around the world. As population density and urbanization increase throughout the globe, the influences of climate change will continue to play a dangerous role in its influence on people's lives. Due to negative health impacts on humans and the economic costs in cities, climate change is one of the most important issues to understand in the 21st century. Air quality and human health are two components of climate change that are impacted most significantly. The bulk of this work is to …


Designing A Mobile App And Online Directory To Increase The Visibility Of Environmental Organizations In A Community, Kayla Vondracek Jan 2021

Designing A Mobile App And Online Directory To Increase The Visibility Of Environmental Organizations In A Community, Kayla Vondracek

Department of Environmental Studies: Undergraduate Student Theses

Concern for environmental degradation, natural resource depletion, and public health has long been a necessary part of a strongly developed and sophisticated society. Humans are primarily responsible for the depletion of the natural environment as it supplies the commodities required to ensure the long-term survival of civilizations. As cultures continue to evolve, so does the practice of land stewardship and protection of resources. With the necessary expansion of industry and housing needed to support a rising human population, the management of natural resources, pollution control, and the environment has become increasingly important to people worldwide. Bernstein and Szuster (2019) suggest …


Precipitation Impact On Crop Yield, Ian Ritchie Jan 2021

Precipitation Impact On Crop Yield, Ian Ritchie

Department of Environmental Studies: Undergraduate Student Theses

Climate change is a massive force impacting and changing many weather trends, including precipitation rates. This thesis will study the relationship between crop yield and changes in precipitation. Understanding crop yield is important in determining overall crop supply every year as well as crop prices. Many factors can have either a negative or a positive impact on crop yields. One of these many factors is precipitation. This thesis looks directly at the impacts of changes in precipitation on corn yield in Iowa from 1991-2020. To do this, a regression analysis was performed to compare changes in yearly precipitation rates for …


Optical Metasurfaces, Fatih Balli Jan 2021

Optical Metasurfaces, Fatih Balli

Theses and Dissertations--Physics and Astronomy

Traditional optical elements, such as refractive lenses, mirrors, phase plates and polarizers have been used for various purposes such as imaging systems, lithographic printing, astronomical observations and display technology. Despite their long-term achievements, they can be bulky and not suitable for miniaturization. On the other hand, recent nanotechnology advances allowed us to manufacture micro and nanoscale devices with ultra-compact sizes. Metasurfaces, 2D engineered artificial interfaces, have emerged as candidates to replace traditional refractive lenses with ultra-thin miniaturized optical elements. They possess sub-wavelength unit cell structures with a specific geometry and material selection. Each unit cell can uniquely tailor the phase, …


Effects Of Microcystis Aeruginosa On New Jersey Aquatic Benthic Macroinvertebrates, Stephanie Beck Jan 2021

Effects Of Microcystis Aeruginosa On New Jersey Aquatic Benthic Macroinvertebrates, Stephanie Beck

Theses, Dissertations and Culminating Projects

As increases in anthropogenic eutrophication and climate change contribute to more severe and frequent cyanobacterial harmful algal blooms in freshwater ecosystems worldwide, understanding the effects and consequences cyanobacterial blooms have on aquatic organisms is crucial. Microcystis aeruginosa is one of the most common cyanobacteria taxa found in cyanobacterial blooms, producing a number of toxins including Microcystins. This study examined the effects of Microcystis aeruginosa on aquatic benthic macroinvertebrates, specifically the pollution intolerant taxa Ephemeroptera, the pollution moderately intolerant taxa Zygoptera, and the pollution tolerant taxa Chironomidae. In a controlled lab environment, macroinvertebrates were exposed to approximately 100,000 cells/ml of Microcystis …


A Survey Of Overlapping Surgery Policies At U.S. Hospitals, Margaret B. Mitchell, Catherine Hammack-Aviran, Ellen W. Clayton, Alexander Langerman Jan 2021

A Survey Of Overlapping Surgery Policies At U.S. Hospitals, Margaret B. Mitchell, Catherine Hammack-Aviran, Ellen W. Clayton, Alexander Langerman

Law Faculty Scholarship

The authors surveyed hospitals across the country on their policies regarding overlapping surgery, and found large variation between hospitals in how this practice is regulated. Specifically, institutions chose to define “critical portions” in a variety of ways, ultimately affecting not only surgical efficiency but also the autonomy of surgical trainees and patient experiences at these different hospitals.


Public Library-Based Social Work Field Placements: Guidance For Public Libraries Planning To Become A Social Work Practicum Site, Elizabeth A. Wahler, Jacob D. Ressler, Sarah C. Johnson, Colleen Rortvedt, Tasha Saecker, John Helling, Michael A. Williams, Danielle Hoover Jan 2021

Public Library-Based Social Work Field Placements: Guidance For Public Libraries Planning To Become A Social Work Practicum Site, Elizabeth A. Wahler, Jacob D. Ressler, Sarah C. Johnson, Colleen Rortvedt, Tasha Saecker, John Helling, Michael A. Williams, Danielle Hoover

Publications and Research

Public libraries are increasingly faced with patron psychosocial needs, including mental health problems, substance use, homelessness, or poverty-related needs. Since library staff are often not trained to address these needs, many are choosing to host on-site social work practicum students to provide information and referrals for patrons presenting with psychosocial needs. However, little existing guidance is available about initiating a social work practicum placement, which can leave libraries unprepared and often “reinventing the wheel”. This manuscript provides guidance on the steps that should be considered by libraries intending to host their first social work practicum student.


Feminist Abolitionist Nursing, Martha Paynter, Keisha Jefferies, Leah Carrier, Lorie Goshin Jan 2021

Feminist Abolitionist Nursing, Martha Paynter, Keisha Jefferies, Leah Carrier, Lorie Goshin

Publications and Research

The converging crises of COVID-19 and racist state violence in 2020 shifted public discourse about marginalization, public health, and racism in unprecedented ways. Nursing responded to the pandemic with heroic commitment and new politicization. But public engagement with systemic racism is forcing a reckoning in nursing. The profession has its own history of racism and of alliance with systems of state control with which to contend. In this article, we argue nursing must adopt an ethics of abolitionism to realize its goals for health and justice. Abolitionism theorizes that policing and prison systems, originating from systems of enslavement and colonial …


The Effect Of Support Systems On Delinquency, Elizabeth S. Bohrer Jan 2021

The Effect Of Support Systems On Delinquency, Elizabeth S. Bohrer

Undergraduate Honors Thesis Projects

There are many reasons why adolescents and young adults turn to delinquent behaviors, much of which result from the environment they are residing in. Copious research has been done on the effects that parent, teacher, peer, and partner relationships have on delinquency, but very little focuses on support systems as a whole. Support systems create positive or negative modeling behaviors for people to follow and individuals will allow these models to influence their own personal behavior patterns. The goal of this study is to assess how a possible change in support systems affects delinquent tendencies in a study group of …


Tracking The Racial Validity Of Placement By Probability, Annie M. Del Principe, Lesley Broder, Lauren Levesque Jan 2021

Tracking The Racial Validity Of Placement By Probability, Annie M. Del Principe, Lesley Broder, Lauren Levesque

Publications and Research

Any placement decision is a gamble on the validity of the mech- anism used. The better the placement mechanism matches the actual pro- ficiencies required for success in a future, real-life context, the more accu- rately it will place students into the best classes for them and the more valid it will prove to be. But what happens if the most obvious, commonsensical approaches to placement that would appear to have the strongest validity— writing tests for placement into writing classes—prove unreliable? Rather than accurately placing students into the “right” class for them, we now know that writing placement tests …


How/Can Gestalt Therapy Promote Liberation From Anti-Black Racism?, Michelle Billies Jan 2021

How/Can Gestalt Therapy Promote Liberation From Anti-Black Racism?, Michelle Billies

Publications and Research

Anti-Black racism is an interruption of contact that often takes place out of awareness, and is continuously enacted through innumerable fixed gestalts at every level of human experience. Gestalt therapy as a movement does not leverage its great potential for undoing fixed gestalts of anti-Black racism, or supporting fluid gestalts of racial liberation; this article explores GT theories and practices that do so. I first discuss how concepts of the field, ground, awareness, consciousness, and contact can be informed by ideas such as intersectionality and double consciousness from Black liberation history as well as theorists such as Crenshaw, DuBois, Fanon, …


Stress And Coping Among Surgery Residents In A Developing Country, Qamar Riaz, Syeda Kausar Ali, Muhammad Rizwan Khan, Abdul Rehman Alvi Jan 2021

Stress And Coping Among Surgery Residents In A Developing Country, Qamar Riaz, Syeda Kausar Ali, Muhammad Rizwan Khan, Abdul Rehman Alvi

Department for Educational Development

Objective: Stress during residency training in surgical disciplines not only hampers professional development but can also compromise patient care and personal health. The purpose of this study was to measure the stress level among the surgical residents, identify factors within the learning and work environment that cause stress, and identify different strategies that the residents use habitually to cope with these stresses.
Methodology: This mix method study was conducted in the department of Surgery at Aga Khan University, Pakistan. Residents' stress level was measured using Perceived Stress Scale (PSS); focus group discussions (FGDs) with faculty and residents explored stressors during …


Evaluating The Effectiveness Of 'Mcq Development Workshop Using Cognitive Model Framework: A Pre-Post Study, Rahila Ali, Amber Shahmim Sultan, Nida Zahid Jan 2021

Evaluating The Effectiveness Of 'Mcq Development Workshop Using Cognitive Model Framework: A Pre-Post Study, Rahila Ali, Amber Shahmim Sultan, Nida Zahid

Department for Educational Development

A workshop on MCQ development using cognitive model framework was conducted for health educators from Aga Khan University (AKU) and other academic institutions. The aim was to develop the skill of preparing MCQs for assessing higher cognitive levels. A pre-post study was conducted, participant satisfaction was evaluated and pre-post test scores were used to assess learning capability of the workshop participants. Out of the 19 who attended the workshop, 16 participated in the pre- and post-tests and were included in the study through convenience sampling. The total duration of the study was six months. There was a significant difference in …


Graduate Nurse Transition Programs Pivotal Point Of Participants’ Practice Readiness Questioned During The Covid-19 Pandemic Crisis: A Scoping Review, Kylie Russell, Dianne Juliff Jan 2021

Graduate Nurse Transition Programs Pivotal Point Of Participants’ Practice Readiness Questioned During The Covid-19 Pandemic Crisis: A Scoping Review, Kylie Russell, Dianne Juliff

Nursing Papers and Journal Articles

Background: The COVID-19 pandemic requires an accessible, practice-ready nursing workforce to assist with the increase in health service delivery. Graduate nurse transition programs are the entry point for most graduates into professional practice, and this review focused on both empirical studies and gray literature to identify at what point practice readiness occurs and what can assist graduate nurses’ transition to become practice ready.

Method: A scoping review was conducted using the Joanna Briggs Institute scoping review framework.

Results: Consensus purports supportive environments, ideally in formal structured graduate transition to practice programs, to enhance graduate nurses’ clinical skills and confidence development. …


Multichannel Mixture Models For Time-Series Analysis And Classification Of Engagement With Multiple Health Services: An Application To Psychology And Physiotherapy Utilization Patterns After Traffic Accidents, Nazanin Esmaili, Quinlan D. Buchlak, Massimo Piccardi, Bernie Kruger, Federico Girosi Jan 2021

Multichannel Mixture Models For Time-Series Analysis And Classification Of Engagement With Multiple Health Services: An Application To Psychology And Physiotherapy Utilization Patterns After Traffic Accidents, Nazanin Esmaili, Quinlan D. Buchlak, Massimo Piccardi, Bernie Kruger, Federico Girosi

Medical Papers and Journal Articles

Background: Motor vehicle accidents (MVA) represent a significant burden on health systems globally. Tens of thousands of people are injured in Australia every year and may experience significant disability. Associated economic costs are substantial. There is little literature on the health service utilization patterns of MVA patients. To fill this gap, this study has been designed to investigate temporal patterns of psychology and physiotherapy service utilization following transport-related injuries.

Method: De-identified compensation data was provided by the Australian Transport Accident Commission. Utilization of physiotherapy and psychology services was analysed. The datasets contained 788 psychology and 3115 physiotherapy claimants and 22,522 …


Coronary 18f-Sodium Fluoride Pet Detects High-Risk Plaque Features On Optical Coherence Tomography And Ct-Angiography In Patients With Acute Coronary Syndrome, Kamran Majeed, Jamie W. Bellinge, Steele C. Butcher, Richard Alcock, Jon Spiro, David Playford, Graham S. Hillis, David E. Newby, Trevor A. Mori, Roslyn Francis, Carl J. Schultz Jan 2021

Coronary 18f-Sodium Fluoride Pet Detects High-Risk Plaque Features On Optical Coherence Tomography And Ct-Angiography In Patients With Acute Coronary Syndrome, Kamran Majeed, Jamie W. Bellinge, Steele C. Butcher, Richard Alcock, Jon Spiro, David Playford, Graham S. Hillis, David E. Newby, Trevor A. Mori, Roslyn Francis, Carl J. Schultz

Medical Papers and Journal Articles

Background and aims: 18F-Sodium Fluoride Positron Emission Tomography (18F–NaF PET) non-invasively detects micro-calcification activity, the earliest stage of atherosclerotic arterial calcification. We studied the association between coronary 18F–NaF uptake and high-risk plaque features on intra-coronary optical coherence tomography (OCT) and CT-angiography (CTCA) and the potential application to patient-level risk stratification.

Methods: Sixty-two prospectively recruited patients with acute coronary syndrome (ACS) underwent multi-vessel OCT, 18F–NaF PET and CTCA. The maximum tissue to background ratio (TBRmax = standardised uptake value (SUV)max/SUVbloodpool) was measured in each coronary segment on 18F–NaF PET scans. High-risk plaque features on OCT …


Could "The Wonder Equation" Help Us To Be More Ethical? A Personal Reflection, Margaret Somerville Jan 2021

Could "The Wonder Equation" Help Us To Be More Ethical? A Personal Reflection, Margaret Somerville

Medical Papers and Journal Articles

This is a personal reflection on what I have learnt as an academic, researching, teaching and participating in the public square in Bioethics for over four decades. I describe a helix metaphor for understanding the evolution of values and the current “culture wars” between “progressive” and “conservative” values adherents, the uncertainty people’s “mixed values packages” engender, and disagreement in prioritizing individual rights and the “common good”. I propose, as a way forward, that individual and collective experiences of “amazement, wonder and awe” have the power to enrich our lives, help us to find meaning and sometimes to bridge the secular/ …


Diagnosing Death 50 Years After The Harvard Brain Death Report, Francis J. O'Keeffe, George L. Mendz Jan 2021

Diagnosing Death 50 Years After The Harvard Brain Death Report, Francis J. O'Keeffe, George L. Mendz

Medical Papers and Journal Articles

More than 50 years after the publication of the Harvard Committee Report that sought to define death according to whole-brain function criteria, this document continues to generate a diversity of opinions regarding how death should be defined. The various perspectives show that doubts linger regarding when brain death should be diagnosed, the criteria to pinpoint the occurrence of death, and the alignment of medical practices seeking to establish human death with these criteria. This study reviews and assesses three perspectives that have made significant contributions to the debate. Attention is also given to definitions of death that depart from the …


Ejection Fraction And Mortality: A Nationwide Register-Based Cohort Study Of 499 153 Women And Men, Simon Stewart, David Playford, Gregory M. Scalia, Philip Currie, David S. Celermajer, David Prior, Jim Codde, Geoff Strange Jan 2021

Ejection Fraction And Mortality: A Nationwide Register-Based Cohort Study Of 499 153 Women And Men, Simon Stewart, David Playford, Gregory M. Scalia, Philip Currie, David S. Celermajer, David Prior, Jim Codde, Geoff Strange

Medical Papers and Journal Articles

Aims: We investigated the sex-based risk of mortality across the spectrum of left ventricular ejection fraction (LVEF) in a large cohort of patients in Australia.

Methods and results: Quantified levels of LVEF from 237 046 women (48.1%) and 256 109 men undergoing first-time, routine echocardiography (2000–2019) were linked to 119 232 deaths (median 5.6 years of follow-up). Overall, 17.6% of men vs. 8.3% of women had an LVEF P< 0.001] in women and 1.21 (95% CI 1.05–1.39; P = 0.008) in men. In women, an LVEF of 60.0–64.9% was also associated with a HR 1.33 (95% CI 1.16–1.52; P< 0.001) for cardiovascular-related mortality. These associations were most striking in women and men aged

Conclusions: Among patients investigated for suspected or established cardiovascular …


Essentials Of A New Clinical Practice Guidance On Familial Hypercholesterolaemia For Physicians, Gerald F. Watts, David R. Sullivan, David L. Hare, Karam M. Kostner, Ari E. Horton, Damon A. Bell, Tom Brett, Ronald J. Trent, Nicola K. Poplawski, Andrew Martin, Shubha Srinivasan, Robert N. Justo, Clara K. Chow, Jing Pang Jan 2021

Essentials Of A New Clinical Practice Guidance On Familial Hypercholesterolaemia For Physicians, Gerald F. Watts, David R. Sullivan, David L. Hare, Karam M. Kostner, Ari E. Horton, Damon A. Bell, Tom Brett, Ronald J. Trent, Nicola K. Poplawski, Andrew Martin, Shubha Srinivasan, Robert N. Justo, Clara K. Chow, Jing Pang

Medical Papers and Journal Articles

Familial hypercholesterolaemia (FH) is a common, heritable and preventable cause of premature coronary artery disease. New clinical practice recommendations are presented to assist practitioners in enhancing the care of all patients with FH. Core recommendations are made on the detection, diagnosis, assessment and management of adults, children and adolescents with FH. Management is under-pinned by the precepts of risk stratification, adherence to healthy lifestyles, treatment of non-cholesterol risk factors and appropriate use of low-density lipoprotein (LDL)-cholesterol-lowering therapies including statins, ezetimibe and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. The recommendations need to be utilised using judicious clinical judgement and shared …


Exported Plasmodial J Domain Protein, Pfe0055c, And Pfhsp70-X Form A Specific Co-Chaperone-Chaperone Partnership, Tanima Dutta, Harpreet Singh, Jason E. Gestwicki, Gregory L. Blatch Jan 2021

Exported Plasmodial J Domain Protein, Pfe0055c, And Pfhsp70-X Form A Specific Co-Chaperone-Chaperone Partnership, Tanima Dutta, Harpreet Singh, Jason E. Gestwicki, Gregory L. Blatch

Medical Papers and Journal Articles

Plasmodium falciparum is a unicellular protozoan parasite and causative agent of a severe form of malaria in humans, accounting for very high worldwide fatality rates. At the molecular level, survival of the parasite within the human host is mediated by P. falciparum heat shock proteins (PfHsps) that provide protection during febrile episodes. The ATP-dependent chaperone activity of Hsp70 relies on the co-chaperone J domain protein (JDP), with which it forms a chaperone-co-chaperone complex. The exported P. falciparum JDP (PfJDP), PFA0660w, has been shown to stimulate the ATPase activity of the exported chaperone, PfHsp70-x. Furthermore, PFA0660w has been shown to associate …


Transfer Learning Artificial Intelligence For Automated Detection Of Atrial Fibrillation In Patients Undergoing Evaluation For Suspected Obstructive Sleep Apnoea: A Feasibility Study, Nestor Gahungu, Afsin Shariar, David Playford, Christopher Judkins, Eli Gabbay Jan 2021

Transfer Learning Artificial Intelligence For Automated Detection Of Atrial Fibrillation In Patients Undergoing Evaluation For Suspected Obstructive Sleep Apnoea: A Feasibility Study, Nestor Gahungu, Afsin Shariar, David Playford, Christopher Judkins, Eli Gabbay

Medical Papers and Journal Articles

Background: Individuals with obstructive sleep apnoea (OSA) experience a higher burden of atrial fibrillation (AF) than the general population, and many cases of AF remain undetected. We tested the feasibility of an artificial intelligence (AI) approach to opportunistic detection of AF from single-lead electrocardiograms (ECGs) which are routinely recorded during in-laboratory polysomnographic sleep studies.

Methods: Using transfer learning, an existing ECG AI model was applied to 1839 single-lead ECG traces recorded during in-laboratory sleep studies without any training of the algorithm. Manual review of all traces was performed by two trained clinicians who were blinded to each other's review. Discrepancies …


Examining The Potential For Coronary Artery Calcium (Cac) Scoring For Individuals At Low Cardiovascular Risk., David Playford, Christian Hamilton-Craig, Girish Dwivedi, Gemma Figtree Jan 2021

Examining The Potential For Coronary Artery Calcium (Cac) Scoring For Individuals At Low Cardiovascular Risk., David Playford, Christian Hamilton-Craig, Girish Dwivedi, Gemma Figtree

Medical Papers and Journal Articles

Atherosclerosis is the commonest cause of death in Australia. Cardiovascular (CV) risk calculators have an important role in preventative cardiology, although they are are strongly age-dependent and designed to identify individuals at high risk of an imminent event. The imprecision around “intermediate” or “low” risk generates therapeutic uncertainty, and a significant proportion of patients presenting with myocardial infarction come from these groups, often with no warning. This highlights a conundrum: “Low” risk does not mean “no” risk.

A fresh approach may be required to address the clinical conundrum around CV preventative approaches in non-high-risk individuals. While probabilistic calculators do not …