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2021

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Association Between Gene Expression And Promoter Methylation Of Cgb3, Gstp1 And Nop56 Genes And Their Potential In Biomarker Development - Associated Cervical Cancer., Palak Singh Jan 2021

Association Between Gene Expression And Promoter Methylation Of Cgb3, Gstp1 And Nop56 Genes And Their Potential In Biomarker Development - Associated Cervical Cancer., Palak Singh

Chulalongkorn University Theses and Dissertations (Chula ETD)

Binding of DNMT1-E7 complex can induce promoter methylation in tumor suppressor genes, such as CCNA1, CADM1 leading to their expression suppression and thus, cause cancer progression. This research establishes the association between methylation-related expression of CGB3 and NOP56 genes in cervical cell lines treated with 5-Azacytidine drug. Using MSP-PCR and qPCR, it was found that the methylation of CGB3 and NOP56 were significantly decreased as concentration of 5-Aza increased and this was inversely related with their expression. This demonstrated the association between gene methylation and the regulation of gene expression which were assessed by 5’-aza drug treatment. Of note, the …

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Identification Of Α-Glucosidase Inhibitors From Black Garlic, Pattraporn Tantiwatcharachai Jan 2021

Identification Of Α-Glucosidase Inhibitors From Black Garlic, Pattraporn Tantiwatcharachai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Black garlic has emerged as one of the fastest-growing health food products on the market. It is processed by incubating fresh garlic under high temperature and high humidity conditions. The process causes the changes in characteristics of black garlic such as texture, flavor, nutrient contents, chemical composition and it pharmacological properties, especially antidiabetic activity. In the present investigation, we applied α-glucosidase inhibition guided isolation to identify active compounds. Four compounds named 5-hydroxymethylfurfural (5-HMF), 5-hydroxymethyl-2-furancarboxylic acid (HMFCA), 4-(hydroxymethyl)phenol and 2-deoxy-ribono-1,4 lactone were isolated. On evaluation against α-glucosidase, HMFCA, 4-(hydroxymethyl)phenol, and 2-deoxy-ribono-1,4 lactone were active against maltase with IC50 values of 18.83 …

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Production And Characterization Of Mannanase From Aureobasidium Sp. For Mannooligosaccharide Preparation From Spent Coffee Ground, Syahriar Nur Maulana Malik Ibrahim Jan 2021

Production And Characterization Of Mannanase From Aureobasidium Sp. For Mannooligosaccharide Preparation From Spent Coffee Ground, Syahriar Nur Maulana Malik Ibrahim

Chulalongkorn University Theses and Dissertations (Chula ETD)

The aims of this study are to produce and characterize mannanase from the selected Thai Aureobasidium strain and use the enzyme for hydrolysis of spent coffee ground extract (SCGE) to prepare mannooligosaccharide (MOs). The optimum condition for SCGE extraction by hot water was 1:30 solid to liquid ratio with 60 min incubation time at 121°C 15 lbs per in2. The maximum yield was 9.5 g/100 g substrate. The second dominant composition of SCGE was hemicellulose at 28 %. Aureobasidium pullulans NRRL 58524 was selected as the best mannanase producer with 8.07 U/mL. The mannanase production medium was optimized by using …

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Proteomics Analysis Of Bt-474 And Skov-3 Cancer Cell Lines Treated With Purified Compounds From Bee Pollen And Cerumen, Teeranai Ittiudomrak Jan 2021

Proteomics Analysis Of Bt-474 And Skov-3 Cancer Cell Lines Treated With Purified Compounds From Bee Pollen And Cerumen, Teeranai Ittiudomrak

Chulalongkorn University Theses and Dissertations (Chula ETD)

Breast and gynaecological cancers are the main causes of global cancer death in females. So far, several compounds have been identified from traditional medicine components and natural products that exhibited anticancer activity. Previously, α-mangostin (α-MG) and apigenin (APG) had been extracted and purified from cerumen of Tetragonula laeviceps and bee pollen of Apis mellifera respectively. Preliminary studies reported that these compounds express antiproliferative activity in several cancer cell lines. In this study, α-MG and APG were investigated for antiproliferation effect in breast cancer cell line BT-474 and ovarian adenocarcinoma cell line SKOV-3 using MTT assay, fluorescent staining coupled with flow …

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Effects Of Types Of Arylamine Based Benzoxazine Binders In Brake Pads On Thermal Degradation Kinetics, Juntasak Wangrangsimakul Jan 2021

Effects Of Types Of Arylamine Based Benzoxazine Binders In Brake Pads On Thermal Degradation Kinetics, Juntasak Wangrangsimakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research aimed to investigate the effect of the alkyl-substituted aromatic amines of polybenzoxazine resins used as binders in the non-asbestos friction composite materials on their thermal degradation and stability. The effects of BA-35x polybenzoxazine resin used as a binder of the brake pad were investigated using thermogravimetric analysis (TGA) under nitrogen atmosphere at various heating rates of 1, 5, 10, 20 and 25 °C/min by applying the model of Advanced iso-conversional method. For the friction composite system using BA-35x as binder, the derivative thermogram exhibited six stages of thermal decomposition reaction. The activation energies of six stages were determined …

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Norfloxacin Adsorption By Activated Carbon From Turmeric Waste, Nuttamon Vanichsetakul Jan 2021

Norfloxacin Adsorption By Activated Carbon From Turmeric Waste, Nuttamon Vanichsetakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

In recent years, extensive use of modern medicines and incompetency of conventional wastewater treatment systems have led to contamination of antibiotics in the environment especially in lower income countries. Antibiotics could interact with bacteria in the environment forming resistance to the medicine. Antibiotics also disrupt the balance of ecosystems affecting various lifeforms. Norfloxacin is a common antibiotic in Thailand with reported levels of contamination in Bang Pakong River. Adsorption process is a cheap and effective approach to remove antibiotics from wastewater effluent. Activated carbon is a common adsorbent in adsorption process due to its porous properties. Agricultural waste presents as …

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Tetracycline Sorption By Magnetic Biochar Derived From Watermelon Rind: Performance And Influential Factors, Phisit Thairattananon Jan 2021

Tetracycline Sorption By Magnetic Biochar Derived From Watermelon Rind: Performance And Influential Factors, Phisit Thairattananon

Chulalongkorn University Theses and Dissertations (Chula ETD)

Tetracycline (TC) antibiotic is one of emerging contaminants in water reservoirs that causes undesirable effects on environment and human health. Magnetic biochar (MBC) is considered a promising sorbent in adsorption process for removal of contaminants with highly efficient and facile operation. In this work, MBC was synthesized by pyrolysis of watermelon rind impregnated with FeCl3 at different pyrolysis temperatures in a range of 600-900 °C prior to applying for TC adsorption. Characteristics of MBC were analyzed by scanning electron microscopy, elemental analyzer, N2 adsorption/desorption, Fourier-transform infrared spectroscopy, Raman spectroscopy, vibrating sample magnetometry, and X-ray diffractometry. The adsorption kinetics, isotherm, effect …

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The Prediction Of Pm2.5 Dispersion In Bangkok (Pathumwan District)Using Cfd Modeling, Punyisa Chaisri Jan 2021

The Prediction Of Pm2.5 Dispersion In Bangkok (Pathumwan District)Using Cfd Modeling, Punyisa Chaisri

Chulalongkorn University Theses and Dissertations (Chula ETD)

City configuration, meteorological conditions and emission source are the important factors affecting the concentration and dispersion of pollutants within urban street canyon. The dispersion of PM2.5 in Pathumwan district, Bangkok which has a characteristics of street canyon was predicted using a Computational Fluid Dynamics (CFD) model. Flow and dispersion of PM2.5 were analyzed using standard k-ε turbulence model. The concentrations of PM2.5 were investigated under different conditions to demonstrate the effect of city configuration in study area, meteorological characteristics, and lockdown due to COVID-19 on PM2.5 concentration. The numerical model was validated with the measured data from the air quality …

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Carbon Dioxide Hydrogenation To Methane Over Silica Supported Nickel Catalysts In A Differential Reactor And Kinetic Model Development, Angkana Khuenpetch Jan 2021

Carbon Dioxide Hydrogenation To Methane Over Silica Supported Nickel Catalysts In A Differential Reactor And Kinetic Model Development, Angkana Khuenpetch

Chulalongkorn University Theses and Dissertations (Chula ETD)

Development of a kinetic model for CO2 methanation over a commercial nickel catalyst was performed to consider pathways of CO2 conversion via Sabatier and RWGS reactions. H2/CO2 ratio in the feed gas composition was varied at the stoichiometry of the Sabatier reaction assuming a fictitious CO2 conversion of 0 to 0.7. Non-stochiometric gas feeding and the addition of product gases, i.e., methane and steam, were also considered to examine reaction orders and inhibition effects. The kinetic tests were carried out at 300–350 °C and 0.1–0.9 MPa. GHSV corresponded to 37,494 h-1. The stable activity was achieved by forcibly stressing the …

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Synthesis And Catalytic Activity Of Layered Double Hydroxide And Metal Sulfide Nanoparticle Composites, Ajirawadee Suwanchan Jan 2021

Synthesis And Catalytic Activity Of Layered Double Hydroxide And Metal Sulfide Nanoparticle Composites, Ajirawadee Suwanchan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Degradation of methylene blue dye was investigated over heterogenous catalytic process using layered double hydroxide and metal sulfide nanoparticle composites. CuCo2S4/NiFe LDH nanocomposites were synthesized using hydrothermal method, and the composites were characterized by SEM and XRD techniques. CuCo2S4 and NiFe LDH were formed with an average particle in the range of 350-450 nm and 2200-3500 nm, respectively. The composites were loaded at 1.8, 3.4, 5.2 and 9.9 wt% of CuCo2S4. CuCo2S4, NiFe LDH and CuCo2S4/NiFe LDH composites were tested at the same condition for methylene blue degradation. The 18CuCo2S4/NiFe LDH composites provided higher catalytic degradation of methylene blue compared …

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Synthesis Of Baicalein Derivatives As Anti-Dengue Agents, Apinya Patigo Jan 2021

Synthesis Of Baicalein Derivatives As Anti-Dengue Agents, Apinya Patigo

Chulalongkorn University Theses and Dissertations (Chula ETD)

Dengue, a mosquito-borne viral disease, is now considered a major international health concern, and hence the development of a new anti-dengue drug is highly desirable. Baicalein is a flavone isolated from the roots of Scutellaria baicalensis and Scutellaria lateriflora. Baicalein derivatives have been shown previously to exhibit a promising anti-dengue activity. In this study, five novel and thirteen known baicalein derivatives were synthesized via semi synthesis from baicalein with modifications at C-5, -6, -7, and -8 positions on ring A and a six-step total synthesis with modifications at the para position on the ring B with a range of electron-withdrawing …

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Use Of Modified Nay Zeolite As Ionophore For Perchlorate Selective Electrode, Boonyakorn Srisassawatkul Jan 2021

Use Of Modified Nay Zeolite As Ionophore For Perchlorate Selective Electrode, Boonyakorn Srisassawatkul

Chulalongkorn University Theses and Dissertations (Chula ETD)

NaY zeolite is well deserved for being employed as a catalyst, adsorbent, and ion exchanger. Therefore, its ion exchange property is used in ion selective electrodes (ISEs). Commercial NaY zeolite was modified with cetyltrimethylammonium bromide (CTAB) in various concentrations (100, 150, and 200 mM), denoted them as 100, 150 and 200 SMZ, respectively. XRD, FT-IR, SEM and TGA/DTG showed good agreement of CTAB adsorption on zeolite surface. Then SMZ is used to fabricate polymeric membrane with polyvinyl chloride (PVC) plasticized with o-nitrophenyl octyl ether (o-NPOE). The best performance of ISE was exhibited at the membrane composition of 200 SMZ: PVC: …

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Chemical Constituents Of Fan-Si Abutilon Indicum Stems, Arum Restu Widyasti Jan 2021

Chemical Constituents Of Fan-Si Abutilon Indicum Stems, Arum Restu Widyasti

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to isolate secondary metabolites from the stems of Abutilon indicum and to evaluate their α-glucosidase, pancreatic lipase, α-chymotrypsin inhibitory activity. Chromatographic fractionation of the n-hexane crude extracts led to the isolation of three known metabolite (1-3). The crude extract from all parts of the plant were evaluated for inhibitory activity on the alpha-glucosidase enzyme. The DCM-soluble roots were active with 10.2% at 25 μg/mL. The hexane and MeOH-soluble stems were active with 11.0% at 25 μg/mL and 8.0% at 0.25 μg/mL. The hexane, DCM, and MeOH-soluble leaves are active with 20.2% at 0.025 μg/mL; 20.0% at 0.025 …

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Modification Of Screen-Printed Carbon Electrode For Detection Of Pesticides, Kansuda Langor Jan 2021

Modification Of Screen-Printed Carbon Electrode For Detection Of Pesticides, Kansuda Langor

Chulalongkorn University Theses and Dissertations (Chula ETD)

Methyl parathion (MP) is an organophosphate pesticide broadly used in agriculture to protect crops and fruits from the damages caused by insects and pests. However, when it is used in large quantities, it can be potentially toxic to humans and animals, causing many poisoning effects. Moreover, its residues can also penetrate the food chain (via agriculture food products) as well as contaminating the environment, leading to air, water and soil pollution. Therefore, rapid determination and reliable quantification of trace level of MP are crucially needed for food safety and environmental monitoring. In this work, a low-cost and portable electrochemical sensor …

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Colorimetric And Fluorescent Detection Of Nucleic Acid By Styryl Dyes, Kotchakorn Supabowornsathit Jan 2021

Colorimetric And Fluorescent Detection Of Nucleic Acid By Styryl Dyes, Kotchakorn Supabowornsathit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Nucleic acid staining dyes are essential tools for the analysis and visualizing of DNA/RNA in vitro and in cellular applications. Although there are several commercially available dyes developed during the past few decades, the selection is still relatively limited, and they are often very costly and associated with undesirable characteristics such as toxicity. Consequently, the discovery of nontoxic, readily available dyes, with desirable and controllable optical characteristics remains important. Styryl dyes have recently gained popularity as potential biological staining agents with many desirable properties including a straightforward synthesis procedure, excellent photostability, tunable optical properties, and high responsiveness towards nucleic acid …

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Synthesis Of Quantum Dot-Based Fluorescent Sensors For Detection Of Anionic Metabolites And Copper (Ii) Ion, Nattakarn Phromsiri Jan 2021

Synthesis Of Quantum Dot-Based Fluorescent Sensors For Detection Of Anionic Metabolites And Copper (Ii) Ion, Nattakarn Phromsiri

Chulalongkorn University Theses and Dissertations (Chula ETD)

Oxalate, citrate, and urate are the anionic metabolites that are the products of the metabolism pathway of living organisms. The high level of these anionic metabolites is related to the diseases. For example, the excess amount of oxalate ions in urine indicates the risk of kidney stones, while the level of citrate can suggest the risk of cancer. The level of urate in urine is related to the risk of gout. The detection of these anionic metabolites is significant and still remains a challenge. Thus, this work aims to develop the more sensitive and selective fluorescence sensing of oxalate in …

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Pna-Immobilized Paper For Detection Of Pcr Amplicons, Nuttapon Jirakittiwut Jan 2021

Pna-Immobilized Paper For Detection Of Pcr Amplicons, Nuttapon Jirakittiwut

Chulalongkorn University Theses and Dissertations (Chula ETD)

DNA detection is very important in diverse fields leading to a continuous increase in the research and development of various DNA sensors. This study focuses on the development of a paper-based DNA sensor by using pyrrolidinyl PNA as a recognition probe. The PNA-immobilized DNA sensor was designed to contain several PNA probes in the same device as a self-check system to increase the accuracy and facilitate the data collection and interpretation. The PNA-immobilized paper was then utilized for the detection of the DNA target, followed by the visualization of the captured target DNA via an enzyme-catalyzed colorimetric reaction. In this …

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Thin-Layer Chromatography For Determination Of Phenolic Compound Profile And Antioxidant Activity Of Thai Honey, Pattraporn Chobpradit Jan 2021

Thin-Layer Chromatography For Determination Of Phenolic Compound Profile And Antioxidant Activity Of Thai Honey, Pattraporn Chobpradit

Chulalongkorn University Theses and Dissertations (Chula ETD)

In this study, a small-scale method using thin-layer chromatography (TLC) was developed to determine profile and antioxidant activity value of Thai honey samples obtained from different flora sources. Prior to TLC analysis, the samples were prepared by solvent extraction with dichloromethane. Using 2, 2-diphenyl-1-picrylhydrazy radical (DPPH•) reacted with the samples extract prior to TLC spot and color detection with imageJ, half-maximal inhibitory concentration (IC50) values of seven honey samples was obtained in a range of 9 to 22 mg/mL in comparison with IC50 values of 0.13 mg/mL for L-ascorbic acid (LA), along with limit of detection (LOD) and limit of …

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Application Of Oxygen Scavenger In Gel Electromembrane Extraction For Determination Of Nitrite And Nitrate, Thidarat Samkumpim Jan 2021

Application Of Oxygen Scavenger In Gel Electromembrane Extraction For Determination Of Nitrite And Nitrate, Thidarat Samkumpim

Chulalongkorn University Theses and Dissertations (Chula ETD)

Gel electromembrane microextraction (G-EME) have been proven as a promising extraction method due to its effectiveness for extraction and preconcentration of charged analytes and its compliance with the principle of green chemistry. G-EME consists of two phases (donor and acceptor phases), separated by a gel membrane made of agarose. The driving force is the electrical potential applied across the membrane. Despite of all the advantages, the common problem was the oxygen generated in the acceptor solution due to the electrolysis of water that could affect the analysis of easily oxidized analyte species such as nitrite/nitrate species. In this work, application …

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A System For Generating Fire Extinguisher Plan And Supporting Fire Evacuation Route In Construction Project, Thiha Nyimin Jan 2021

A System For Generating Fire Extinguisher Plan And Supporting Fire Evacuation Route In Construction Project, Thiha Nyimin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Fires in under-construction threaten worker safety and have a lot of negative impacts on many aspects of construction that were reported the past few years. Due to the dynamic nature of construction, the fire safety plan in construction needed to be reviewed and updated according to construction progress. The conventional approach or manual process to develop the fire safety plan for a construction project can be a time-consuming and enormous labor-intensive task. Furthermore, some of the emergency signs are unclear due to the nature of construction and some are not showing the correct evacuation route because of the structural design …

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Experimental Investigation And Numerical Modelling Of Biomechanical Variation Of Decomposed Root: An Application Of Vegetated Slope Stability, Trung Nghia Phan Jan 2021

Experimental Investigation And Numerical Modelling Of Biomechanical Variation Of Decomposed Root: An Application Of Vegetated Slope Stability, Trung Nghia Phan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Plant root reinforcement in soil bioengineering has gained increasing interest as a means of sustainable and environmentally friendly soil reinforcement and stabilization. In addition, quantifying evolutions of the biomechanical properties and mechanical root reinforcement to soil with the duration of root decomposition is important to agricultural land-use strategy and to soil stabilization purpose. However, the variations of these properties of the roots of herbaceous species, especially following herbicide application, have rarely been studied. This study aims to comprehensively measure the root morphological traits, root biomechanical properties, and root reinforcement of two contrasting vetiver species (Chrysopogon nemoralis and Chrysopogon zizanioides). In …

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Subjective Perception Of Nasal Breathing ; Identifying Patient At Risk Of A Poor Surgical Outcome, Dichapong Kanjanawasee Jan 2021

Subjective Perception Of Nasal Breathing ; Identifying Patient At Risk Of A Poor Surgical Outcome, Dichapong Kanjanawasee

Chulalongkorn University Theses and Dissertations (Chula ETD)

No abstract provided.

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Efficacy And Safety Of Phlai Capsule Compared To Placebo As The Treatment In Allergic Rhinitis Patients, Minh Phuoc Hoang Jan 2021

Efficacy And Safety Of Phlai Capsule Compared To Placebo As The Treatment In Allergic Rhinitis Patients, Minh Phuoc Hoang

Chulalongkorn University Theses and Dissertations (Chula ETD)

: Preclinical studies demonstrated anti-inflammatory effects of Phlai capsule containing Zingiber montanum (J.Koenig) Link ex A.Dietr. extract. However, its clinical effect on allergic rhinitis is not evident. : We sought to assess the efficacy and safety of Phlai for treating allergic rhinitis. : A randomized, double-blind, placebo-controlled study was conducted. Patients with allergic rhinitis were randomized into three groups and received 100 mg (compound D 4 mg) of Phlai capsule or 200 mg (compound D 8 mg) of Phlai capsule or placebo once a day for 4 weeks. The primary outcome was a change in the reflective total five symptom …

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Histone 3 And Histone 4 Acetylation Pattern In Well-Differentiated Thyroid Lesions And Normal Thyroid Tissue With Their Potential In Diagnostic Implication, Nishal Chhetri Jan 2021

Histone 3 And Histone 4 Acetylation Pattern In Well-Differentiated Thyroid Lesions And Normal Thyroid Tissue With Their Potential In Diagnostic Implication, Nishal Chhetri

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study estimated the histone modification (hypoacetylation or hyperacetylation) in thyroid lesions, using immunohistochemistry compared with their normal counterpart. FFPE sections of surgically removed PTC, FA, FTC, and nodular goiter samples were collected from the archives of the Department of Pathology, Faculty of Medicine, Chulalongkorn University from 2016-2018 and stained with anti-acetyl histone 3 antibody (H3K9/K14ac) and anti-acetyl histone 4 antibody (H4K5,8,12 and 16ac). The intensity and proportion of immunostaining of the lesions and their normal thyroid tissue counterparts were automatically scored by Aperio ImageScope software. A total of 147 benign and malignant thyroid lesions cases, including 28 FA, 50 …

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Optical Coherence Tomography Angiography Biomarkers In Diabetic Nephropathy Patients In Thailand : A Diabetic Eye And Kidney Diseases (Dek-D) Study, Nuntachai Surawatsatien Jan 2021

Optical Coherence Tomography Angiography Biomarkers In Diabetic Nephropathy Patients In Thailand : A Diabetic Eye And Kidney Diseases (Dek-D) Study, Nuntachai Surawatsatien

Chulalongkorn University Theses and Dissertations (Chula ETD)

Diabetes mellitus (DM) can cause many microvascular complications including diabetic retinopathy (DR) and diabetic nephropathy (DN). It is estamated that about one-third of diabetic patients have DR and about 40% have DN. DR and DN share a common pathology in microvasculature. With the development of optical coherence tomography angiography (OCTA), the examination of retinal capillary is more convenient and less invasive. This is a cross-sectional observational study aimed to identify OCTA parameters as biomarkers that predict the diabetic nephropathy and association with 24-hour urine albumin level in diabetic patients. 186 eyes from 93 individuals were divided into 3 groups according …

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Bending Radiograph As Predictive Factor Of In-Brace Correction (Ibc) In Adolescent Idiopathic Scoliosis (Ais), Raden Achmad Candra Putra Jan 2021

Bending Radiograph As Predictive Factor Of In-Brace Correction (Ibc) In Adolescent Idiopathic Scoliosis (Ais), Raden Achmad Candra Putra

Chulalongkorn University Theses and Dissertations (Chula ETD)

Introductions: In-brace correction (IBC) is one of the most important factors in bracing treatment for Adolescent Idiopathic Scoliosis (AIS). Several factors influenced IBC achievement. The curve flexibility found to be associated with the IBC. One of the most common methods for assessing curve flexibility is to take a side bending radiograph. It has been widely used as a predictor of surgical correction in AIS. However, bending radiograph to predict the amount of fulltime IBC is not cleared in orthotics practice. The purpose of this study was to evaluate flexibility as measured by a side bending radiograph as a predictive factor …

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Sentiment Analysis Of Messages On Twitter Related To Covid-19 Using Deep Learning Approach, Chotika Imvimol Jan 2021

Sentiment Analysis Of Messages On Twitter Related To Covid-19 Using Deep Learning Approach, Chotika Imvimol

Chulalongkorn University Theses and Dissertations (Chula ETD)

The widespread situation of the Coronavirus-19 (COVID-19) pandemic is a tangible and pressing concern. Many changes in terms of lifestyle are necessary to reduce the chance of infection. While citizens have gone through different emotions, they share their thoughts and interactions on social media, especially on Twitter. COVID-19 related messages can imply social emotion. This study performs sentiment analysis on tweets and annotated them into six classes of positive and negative feelings consisting of anger, disgust, fear, sadness, joy, and surprise. We analyzed both textual information and historical data. We collected 120,642 unique tweets datasets between 1 January 2020 and …

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Adaptive Image Preprocessing And Augmentation For Disease Screening On Multi-Source Chest X-Ray Datasets, Wasunan Chokchaithanakul Jan 2021

Adaptive Image Preprocessing And Augmentation For Disease Screening On Multi-Source Chest X-Ray Datasets, Wasunan Chokchaithanakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Research on deep learning models for chest radiology applications has increased attention by the public. However, most works focus on developing models using in-domain data, so the significant drawback, when applied in real-world scenarios, was the mismatched data with the training set. Consequently, some models perform inferior at the deployment stage. This work focused on the effects of dataset mismatch on chest radiography and analyzed the methods the overcome the mismatch issues. The lung balance contrast enhancement technique (lung BCET) automatically identifies the lung region and normalizes the image accordingly to improve the robustness of out-of-domain data developed. Additionally, augmentation …

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Development Of A Curriculum Based On Content And Language Integrated Learning And Competency-Based Education For Enhancing Business English Writing Ability Of Undergraduate Students, Meassnguon Saint Jan 2021

Development Of A Curriculum Based On Content And Language Integrated Learning And Competency-Based Education For Enhancing Business English Writing Ability Of Undergraduate Students, Meassnguon Saint

Chulalongkorn University Theses and Dissertations (Chula ETD)

The purposes of this study were 1) to develop a curriculum based on content and language integrated language learning and competency-based education for enhancing business English writing ability of undergraduate students 2) to investigate the effectiveness of a developed curriculum. The research and development process consists of four phases: 1) studying the research problem and significance, and learning approaches, 2) developing a curriculum based on content and language integrated learning and competency-based education, 3) studying the effectiveness of the developed curriculum, and 4) revising and improving the developed curriculum. This pre-experimental research involved 13 undergraduate students in the business major …

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Impact Of Early Childhood Caries On Oral Health-Related Quality Of Life Among 5-Year-Old Children In Mandalay, Myanmar, Saw Nay Min Jan 2021

Impact Of Early Childhood Caries On Oral Health-Related Quality Of Life Among 5-Year-Old Children In Mandalay, Myanmar, Saw Nay Min

Chulalongkorn University Theses and Dissertations (Chula ETD)

Purpose: The study aimed to develop the cross-cultural adaptation and psychometric properties of the Myanmar Version of SOHO-5 and assess the impact of ECC on oral health quality of life among 5-year-old children in Mandalay using the Myanmar version of the SOHO-5 questionnaire. Materials and methods: The Myanmar SOHO-5 version was conducted with the forward-backward translation method and investigated the content validity, internal consistency, test-retest reliability, construct validity, and discriminant validity on 5-year-old children and their parents in phase I. A cross-sectional study was conducted using a self-administered questionnaire to investigate the impact of ECC and relative factors on the …

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